CN106234761A - Heat-clearing and toxic substances removing element and preparation method thereof - Google Patents
Heat-clearing and toxic substances removing element and preparation method thereof Download PDFInfo
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- CN106234761A CN106234761A CN201610600123.8A CN201610600123A CN106234761A CN 106234761 A CN106234761 A CN 106234761A CN 201610600123 A CN201610600123 A CN 201610600123A CN 106234761 A CN106234761 A CN 106234761A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
Abstract
The invention discloses a kind of heat-clearing and toxic substances removing element and preparation method thereof; Semen phaseoli radiati and Radix Glycyrrhizae in raw material use particular extraction procedure to propose effective ingredient; add natural plant composition again; part material is carried out pretreatment; the raw material of pretreatment can strengthen the effect of Chinese medicine extract and natural plant composition, and prepared heat-clearing and toxic substances removing element is possible not only to de-mould removing toxic substances, is in harmonious proportion the property of medicine, cushion toxicity and strong; protection animal health, the most also has certain therapeutical effect to bronchitis.
Description
Technical field
The present invention relates to a kind of heat-clearing and toxic substances removing element and preparation method thereof, belong to field of animal feed.
Background technology
Feedstuff, is the general name of the food of everyone domesticated animal, compares narrowly general feeds and generally refers to agricultural
Or the food of animal husbandry domesticated animal.Feedstuff include Semen sojae atricolor, bean cake, Semen Maydis, fish flour, aminoacid, the miscellaneous dregs of rice, additive, whey powder,
The feedstuff of more than ten kinds such as oils and fats, meat meal tankage, corn, sugar grass.
Animal feed is all directly to add various Chinese medicines, DeGrain at present.
Summary of the invention
It is an object of the invention to provide a kind of heat-clearing and toxic substances removing element and preparation method thereof, Semen phaseoli radiati and Radix Glycyrrhizae in raw material use spy
Determining extracting method and propose effective ingredient, then add natural plant composition, part material is carried out pretreatment, the raw material of pretreatment can
To strengthen Chinese medicine extract and the effect of natural plant composition, prepared heat-clearing and toxic substances removing element is possible not only to de-mould removing toxic substances, harmonizing drug
Property, cushion toxicity and strong, protect animal health, the most also bronchitis had certain therapeutical effect.
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 900-1000 part, vitamin C
50.0-50.2 part, vitamin E 20.0-20.2 part.
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 900-1000 part, vitamin C
50.0-50.20 part, vitamin E 20.0-20.2 part, Semen Granati 66-70 part, Semen Sinapis 44-46 part, Flos Semen Lablab Album 38-42 part,
Arginine 13-15 part, copper sulfate 8.6-9.4 part, cobaltous chloride 7-8 part, dimethyl fumarate 4-6 part, sodium citrate 5.5-6.5
Part, sodium carboxymethyl cellulose 2-3 part, zeolite 7.8-9.0 part, kieselguhr 8-10 part.
Described Chinese medicine extract is made up of the raw material of following masses number: Semen phaseoli radiati 17.3-17.7 part, Radix Glycyrrhizae 8.5-
9.5 part.
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, with 95% ethanol-acetone mixed liquor of 11-13 times of quality at 40-50 DEG C of bar
Extract 90-110 minute under part, filter, obtain medicinal residues；
(2) medicinal residues are extracted 3 times with the distilled water of 20 times of quality under the conditions of 80-85 DEG C, each 110-130 minute, mistake
Filter, merging filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.09-1.11, adds 95% ethanol and make the containing alcohol of concentrated solution
Amount is 70%, centrifugal, and isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) the Semen Granati distilled water of 15-17 times of quality decocts 50-70 minute, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 30-40 minute,
Filter, obtain filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.07-1.09, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, adds pretreated raw material, vitamin C, dimension life
Element E, arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mixed
Close 20-30 minute, standby；
(6) taking remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mixing 20-30 divides
Clock, subpackage, to obtain final product.
The solution have the advantages that:
1, Semen phaseoli radiati and Radix Glycyrrhizae use specific preparation method to obtain Chinese medicine extract, have effectively extracted the one-tenth of de-mould removing toxic substances
Point, effect is better than being provided without extracting method and the Semen phaseoli radiati of other extracting method and Radix Glycyrrhizae.
2, raw material uses the Semen Granati of plant component, Semen Sinapis and Flos Semen Lablab Album, containing natural constituent, make without secondary
With.
3, first the Semen Granati in raw material, Semen Sinapis and Flos Semen Lablab Album in preparation process, pretreatment is carried out, more former with other
Heat-clearing and toxic substances removing element made by material.
4, the raw material of the pretreatment of the present invention can strengthen the effect of Chinese medicine extract and natural plant composition, San Zhelian
With, the heat-clearing and toxic substances removing element prepared is possible not only to de-mould removing toxic substances, is in harmonious proportion the property of medicine, cushion toxicity and strong, protects animal health,
The most also bronchitis is had certain therapeutical effect.
Detailed description of the invention
Below by embodiment, the invention will be further described.
Embodiment 1:
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 900 parts, vitamin C 50.0
Part, vitamin E 20.0 parts, Semen Granati 66 parts, Semen Sinapis 44 parts, Flos Semen Lablab Album 38 parts, arginine 13 parts, 8.6 parts of copper sulfate,
Cobaltous chloride 7 parts, dimethyl fumarate 4 parts, sodium citrate 5.5 parts, sodium carboxymethyl cellulose 2 parts, 7.8 parts of zeolite, kieselguhr 8
Part.
Described Chinese medicine extract is made up of the raw material of following masses number: 17.3 parts of Semen phaseoli radiati, 8.5 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, carry under the conditions of 40 DEG C with 95% ethanol-acetone mixed liquor of 11 times of quality
Take 90 minutes, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 3 times under the conditions of 80 DEG C, each 110 minutes, filter, merge
Filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.09, adds 95% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) the Semen Granati distilled water of 15 times of quality decocts 50 minutes, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 30 minutes, mistake
Filter, obtains filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.07, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, adds pretreated raw material, vitamin C, dimension life
Element E, arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mixed
Close 20 minutes, standby；
(6) take remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mix 20 minutes,
Subpackage, to obtain final product.
Embodiment 2:
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 950 parts, vitamin C 50.1
Part, vitamin E 20.1 parts, Semen Granati 68 parts, Semen Sinapis 45 parts, Flos Semen Lablab Album 40 parts, arginine 14 parts, 9 parts of copper sulfate, chlorine
Change cobalt 7.5 parts, dimethyl fumarate 5 parts, sodium citrate 6 parts, sodium carboxymethyl cellulose 2.5 parts, 7.9 parts of zeolite, kieselguhr 9
Part.
Described Chinese medicine extract is made up of the raw material of following masses number: 17.5 parts of Semen phaseoli radiati, 9 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, carry under the conditions of 45 DEG C with 95% ethanol-acetone mixed liquor of 12 times of quality
Take 100 minutes, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 3 times under the conditions of 82 DEG C, each 120 minutes, filter, merge
Filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.10, adds 95% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) the Semen Granati distilled water of 16 times of quality decocts 60 minutes, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 35 minutes, mistake
Filter, obtains filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.08, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, adds pretreated raw material, vitamin C, dimension life
Element E, arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mixed
Close 25 minutes, standby；
(6) take remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mix 25 minutes,
Subpackage, to obtain final product.
Embodiment 3:
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 1000 parts, vitamin C
50.20 parts, vitamin E 20.2 parts, Semen Granati 70 parts, Semen Sinapis 46 parts, Flos Semen Lablab Album 42 parts, arginine 15 parts, copper sulfate
9.4 parts, cobaltous chloride 8 parts, dimethyl fumarate 6 parts, sodium citrate 6.5 parts, sodium carboxymethyl cellulose 3 parts, 9.0 parts of zeolite, silicon
Diatomaceous earth 10 parts.
Described Chinese medicine extract is made up of the raw material of following masses number: 17.7 parts of Semen phaseoli radiati, 9.5 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, carry under the conditions of 50 DEG C with 95% ethanol-acetone mixed liquor of 13 times of quality
Take 110 minutes, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 3 times under the conditions of 85 DEG C, each 130 minutes, filter, merge
Filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.11, adds 95% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) the Semen Granati distilled water of 17 times of quality decocts 70 minutes, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 40 minutes, mistake
Filter, obtains filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.09, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, adds pretreated raw material, vitamin C, dimension life
Element E, arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mixed
Close 30 minutes, standby；
(6) take remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mix 30 minutes,
Subpackage, to obtain final product.
Comparative example 1:
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 1200 parts, vitamin C 45
Part, vitamin E 25 parts, Semen Granati 60 parts, Semen Sinapis 50 parts, Flos Semen Lablab Album 35 parts, arginase 12 0 part, 5 parts of copper sulfate, chlorination
Cobalt 10 parts, dimethyl fumarate 2 parts, sodium citrate 8 parts, sodium carboxymethyl cellulose 1 part, 10 parts of zeolite, 5 parts of kieselguhr.
Described Chinese medicine extract is made up of the raw material of following masses number: 20 parts of Semen phaseoli radiati, 7 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, carry under the conditions of 35 DEG C with 95% ethanol-acetone mixed liquor of 15 times of quality
Take 120 minutes, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 3 times under the conditions of 70 DEG C, each 100 minutes, filter, merge
Filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.15, adds 95% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) the Semen Granati distilled water of 12 times of quality decocts 90 minutes, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 20 minutes, mistake
Filter, obtains filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.06, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, adds pretreated raw material, vitamin C, dimension life
Element E, arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mixed
Close 15 minutes, standby；
(6) take remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mix 35 minutes,
Subpackage, to obtain final product.
Comparative example 2:
A kind of heat-clearing and toxic substances removing element, the preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, carry under the conditions of 45 DEG C with 70% ethanol of 12 times of quality-chloroform mixed liquor
Take 100 minutes, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 2 times under the conditions of 82 DEG C, each 120 minutes, filter, merge
Filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.10, adds 70% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation acetone of quality, 2 times of precipitation dehydrated alcohol of quality, 3 times precipitate quality
Distilled water wash, is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract.
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
Remaining is with embodiment 2.
Comparative example 3:
A kind of heat-clearing and toxic substances removing element, is made up of the raw material of following masses number: Chinese medicine extract 1000 parts, vitamin C
50.20 parts, vitamin E 20.2 parts, Flos Semen Lablab Album 42 parts, arginine 15 parts, 9.4 parts of copper sulfate, cobaltous chloride 8 parts, fumaric acid two
Methyl ester 6 parts, sodium citrate 6.5 parts, sodium carboxymethyl cellulose 3 parts, 9.0 parts of zeolite, 10 parts of kieselguhr.
A kind of heat-clearing and toxic substances removing element, its preparation method is:
(1) Chinese medicine extract taking 1/3 mass is placed in mixer, adds vitamin C, vitamin E, Flos Semen Lablab Album, essence
Propylhomoserin, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mix 30 points
Clock, standby；
(2) take remaining Chinese medicine extract to be placed in another mixer, add step (1) gained material, mix 30 minutes,
Subpackage, to obtain final product.
Remaining is with embodiment 3.
Detoxification efficiency the most of the present invention is tested
Take AFB1, vomitoxin, T-2 toxin, ochratoxin respectively, be configured to the solution of variable concentrations,
Being the concentration before the detoxification of each mycotoxin solution, concrete numerical value is shown in Tables 1 and 2.Taking centrifuge tube, to be separately added into 10ml above-mentioned
The mycotoxin solution prepared, then the product 15mg that addition embodiment 1-3 and comparative example 1-3 prepare in centrifuge tube respectively,
Making its concentration in the solution is 1.5mg/ml.Arranging blank group (adding distilled water 1.5ml), all samples sets 3 simultaneously
Individual repetition.All samples in 37 DEG C of water bath with thermostatic control agitators with 150r/min vibrate detoxification 2h.Then it is centrifuged with 3000r/min
10min, collects supernatant, measures the content of each mycotoxin in supernatant.Calculate virus elimination rate, the results are shown in Table 1 and table 2.
Concentration × 100 before virus elimination rate (%)=(concentration after concentration-detoxification before detoxification)/detoxification
Table 1 present invention is to AFB1 and vomitoxin detoxification situation
Table 2 present invention is to T-2 toxin and ochratoxin detoxification situation
Knowable to Tables 1 and 2, heat-clearing and toxic substances removing element (embodiment 1-3) that the present invention prepares is to AFB1, vomiting poison
Element, T-2 toxin, ochratoxin virus elimination rate all more than 90%, and effect is substantially better than comparative example 1, and (technological parameter is not
Together) with comparative example 2 (extraction process of Chinese medicine extract is different), comparative example 3 (being not added with Semen Granati and Semen Sinapis in raw material), especially
It is that the effect with embodiment 2 is optimum, it is seen that technological parameter, the extraction process of Chinese medicine extract and natural plant composition are all to system
The curative effect of the product obtained has an impact, and therefore present invention employs specific technological parameter, the extraction process of Chinese medicine extract and choosing
Selecting suitable natural plant composition, prepared heat-clearing and toxic substances removing element can take off mould removing toxic substances, protects animal health,
2. the present invention impact on mouse cough
Taking mice (20 ± 2g) 70, male and female half and half, digital random method is divided into 7 groups, i.e. Normal group, embodiment 1-3
Group and comparative example 1-3 group, often group 10.Embodiment 1-3 group and comparative example 1-3 group embodiment 1-3 group and comparative example 1-3 group respectively
The feedstuff 1.5g/kg prepared, Normal group gives 0.9% sodium chloride solution 1.5ml/kg, and every mice dosing interval is about
4min, continuous gastric infusion 7d, 1h after last administration, mice is buckled in 500ml beaker, then will inject strong aqua ammonia 0.2ml's
Cotton balls is put into rapidly in beaker, adds a cover screen cloth above, and with mice abdominal muscle strong contraction, and to magnify mouth be cough action index,
Cough number of times in the cough latent period of record mice and 3min.Test data employing SPSS 13.0 analyzes software and carries out statistical
Analysis.Result is as shown in table 3.
Table 3 present invention on the impact of mouse cough (N=10)
| Group | Incubation period (s) | Cough number of times (secondary) in 3min |
| Normal group | 23.20±5.72 | 32.10±7.27 |
| Embodiment 1 | 32.50±5.47 | 19.70±4.21 |
| Embodiment 2 | 36.10±6.15 | 15.60±4.09 |
| Embodiment 3 | 34.70±5.83 | 18.30±4.68 |
| Comparative example 1 | 27.20±5.31 | 25.50±5.35 |
| Comparative example 2 | 26.30±5.58 | 27.20±5.54 |
| Comparative example 3 | 27.00±5.69 | 26.90±5.82 |
As known from Table 3, heat-clearing and toxic substances removing that the present invention prepares element (embodiment 1-3) substantially increases mouse cough incubation period, subtracts
Few mouse cough number of times, and effect is substantially better than comparative example 1 (technological parameter is different) and comparative example 2 (carrying of Chinese medicine extract
Taking technique is different), comparative example 3 (being not added with Semen Granati and Semen Sinapis in raw material), the especially effect with embodiment 2 optimum, can
See that the curative effect of prepared product is all had an impact, therefore by technological parameter, the extraction process of Chinese medicine extract and natural plant composition
Present invention employs specific technological parameter, the extraction process of Chinese medicine extract and select suitable natural plant composition, preparing
Heat-clearing and toxic substances removing element can reduce cough number of times, bronchitis is had certain therapeutical effect.
In sum: Semen phaseoli radiati and Radix Glycyrrhizae in the present invention have employed specific extracting method, select suitable natural plants
Composition, under specific process integration effect, the heat-clearing and toxic substances removing element prepared is possible not only to de-mould removing toxic substances, the mediation property of medicine, abirritant
Thing toxicity and strong, protects animal health, can reduce cough number of times simultaneously, have certain therapeutical effect to bronchitis.
Claims (5)
1. a heat-clearing and toxic substances removing element, is characterized by: be made up of the raw material of following masses number: Chinese medicine extract 900-1000 part,
Vitamin C 50.0-50.2 part, vitamin E 20.0-20.2 part.
2. a heat-clearing and toxic substances removing element, is characterized by: be made up of the raw material of following masses number: Chinese medicine extract 900-1000 part,
Vitamin C 50.0-50.20 part, vitamin E 20.0-20.2 part, Semen Granati 66-70 part, Semen Sinapis 44-46 part, Flos Semen Lablab Album
38-42 part, arginine 13-15 part, copper sulfate 8.6-9.4 part, cobaltous chloride 7-8 part, dimethyl fumarate 4-6 part, sodium citrate
5.5-6.5 part, sodium carboxymethyl cellulose 2-3 part, zeolite 7.8-9.0 part, kieselguhr 8-10 part.
3. a kind of heat-clearing and toxic substances removing element as claimed in claim 2, is characterized by:
Chinese medicine extract is made up of the raw material of following masses number: Semen phaseoli radiati 17.3-17.7 part, Radix Glycyrrhizae 8.5-9.5 part.
4. a kind of heat-clearing and toxic substances removing element, is characterized by:
The preparation method of Chinese medicine extract is:
(1) Radix Glycyrrhizae is pulverized, cross 10 mesh sieves, with 95% ethanol-acetone mixed liquor of 11-13 times of quality under the conditions of 40-50 DEG C
Extract 90-110 minute, filter, obtain medicinal residues；
(2) the medicinal residues distilled water of 20 times of quality is extracted 3 times under the conditions of 80-85 DEG C, each 110-130 minute, filter, close
And filtrate；
(3) filtrate is concentrated into the concentrated solution that relative density is 1.09-1.11, adds 95% ethanol and make the alcohol content of concentrated solution to be
70%, centrifugal, isolated precipitates；
(4) precipitation successively with 2 times of precipitation ether of quality, 2 times of the precipitation dehydrated alcohol of quality, distillations of 3 times of precipitation quality
Water washs, and is dried, standby；
(5) Semen phaseoli radiati being pulverized, cross 10 mesh sieves, the extract obtained with upper step is mixed homogeneously, and is Chinese medicine extract；
Wherein in 95% ethanol-acetone mixed liquor, the volume ratio of 95% ethanol and acetone is 3:1.
5. a kind of heat-clearing and toxic substances removing element as claimed in claim 2, is characterized by:
Its preparation method is:
(1) the Semen Granati distilled water of 15-17 times of quality decocts 50-70 minute, filters, obtains filtrate I and filtering residue I；
(2) filtering residue I is mixed homogeneously with Semen Sinapis and Flos Semen Lablab Album, join in filtrate I, supersound extraction 30-40 minute, mistake
Filter, obtains filtrate II；
(3) adding 95% ethanol in filtrate II is 40% to alcohol content, is centrifugally separating to obtain supernatant；
(4) supernatant is evaporated to the extractum that relative density is 1.07-1.09, obtains the raw material of pretreatment；
(5) Chinese medicine extract taking 1/3 mass is placed in mixer, add pretreated raw material, vitamin C, vitamin E,
Arginine, copper sulfate, cobaltous chloride, dimethyl fumarate, sodium citrate, sodium carboxymethyl cellulose, zeolite, kieselguhr, mix 20-
30 minutes, standby；
(6) take remaining Chinese medicine extract to be placed in another mixer, add step (5) gained material, mix 20-30 minute,
Subpackage, to obtain final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108651745A (en) * | 2017-03-28 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | The chicken feed of function is removed with toxin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696888A (en) * | 2012-06-13 | 2012-10-03 | 郑州峰源生物技术有限公司 | Feed mycotoxin removing agent |
| CN104642803A (en) * | 2015-02-04 | 2015-05-27 | 周敏忠 | Chicken feed |
| CN104799054A (en) * | 2015-04-02 | 2015-07-29 | 广西大学 | Laying hen fodder |
| CN105146175A (en) * | 2015-08-28 | 2015-12-16 | 明光市田地农产品贸易有限公司 | Corn straw milk cow feed containing compound vitamin and preparation method thereof |
-
2016
- 2016-07-27 CN CN201610600123.8A patent/CN106234761A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696888A (en) * | 2012-06-13 | 2012-10-03 | 郑州峰源生物技术有限公司 | Feed mycotoxin removing agent |
| CN104642803A (en) * | 2015-02-04 | 2015-05-27 | 周敏忠 | Chicken feed |
| CN104799054A (en) * | 2015-04-02 | 2015-07-29 | 广西大学 | Laying hen fodder |
| CN105146175A (en) * | 2015-08-28 | 2015-12-16 | 明光市田地农产品贸易有限公司 | Corn straw milk cow feed containing compound vitamin and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 丁炳扬 等: "《天目山植物志 第2卷 罂粟科—山茱萸科》", 31 March 2010, 浙江大学出版社 * |
| 刘京宝 等: "《中国南北过渡带主要作物栽培》", 31 January 2014, 中国农业科学技术出版社 * |
| 周玲仙，殷建忠，赵楠等: "《云南特有食物图鉴》", 31 March 2012, 云南科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108651745A (en) * | 2017-03-28 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | The chicken feed of function is removed with toxin |
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Application publication date: 20161221 |