CN106214929A - A kind of Chinese medicine composition treating cyclomastopathy and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating cyclomastopathy and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition treating cyclomastopathy and preparation method thereof, belongs to technical field of Chinese medicines.It is made up of the raw material of following weight portion: Fructus Akebiae 15 30 parts, Radix Ranunculi Ternati 5 10 parts, Herba Salviae Chinensis 5 20 parts, the Rhizoma Pinelliae 3 11 parts, Folium Symplocoris Caudatae 2 10 parts, Cornu Cervi Degelatinatum 2 10 parts, Caulis Spatholobi 10 15 parts, Bulbus Allii Macrostemonis 10 15 parts, Semen Momordicae 10 15 parts, Fructus anethi 7 11 parts, Semen Citri Reticulatae 9 21 parts, Fructus Toosendan 10 30 parts, Flos Rosae Rugosae 15 20 parts, Rhizoma Curculiginis 10 15 parts, Retinervus Luffae Fructus 15 parts, Fructus Liquidambaris 15 parts.This Chinese medicine composition treats cyclomastopathy by resolving depression eliminating stagnation, regulating blood circulation, the principle of the clear core of blood stasis dispelling, has instant effect, good effect, the advantage that has no side effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating cyclomastopathy and preparation side thereof
Method.
Background technology
Cyclomastopathy is women commonly encountered diseases and frequently-occurring disease, multiple with young and middle-aged women, especially with unmarried or do not give birth to, do not feed
Newborn and dysthymic women the most easily suffers from this disease.Cyclomastopathy is normal breast lobule physiological hypertrophy and subinvolution,
Mammary gland normal configuration gets muddled, and belongs to pathological proliferation, and it is a class disease of the most noninflammatory but also non-tumor.Cause of disease spiritedness because of
Element, bad life habits, diet are unreasonable.Direct stimulation can change human internal environment, thus affects hormonal system function,
The secretion causing a certain or several hormone occurs abnormal.The bad Nervous and Mental Factors such as spirit is excessively nervous, emotion is excessively exciting, all
The breast hyperplasia tissue that should restore may be made to can not get restoring or meromorphosis, in the course of time, just form cyclomastopathy,
And these bad direct stimulations also can increase the weight of existing cyclomastopathy symptom.Also have many anthropic factors and life style because of
Element, artificial abortion, fertility or fertility in more than 30 years old, not suckling, man and wife gets along well, and the breast of tension worn by health product containing hormone etc.
Cover, the medicated bra of tension is easily oppressed lymph and blood circulation, is all hindered Breast health.Additionally dietary structure is unreasonable, as fat is taken the photograph
Enter too much, the endocrine of ovary can be affected, strengthen the stimulation of estrogen on breast epithelial cell thus cause cyclomastopathy.Clinical
Show as main with mastalgia, lump etc., and how to change with menstrual cycle, feelings will, the factor such as overwork relevant.Typically giving birth to
The reason cycle occurs front obvious, can alleviate or disappear after end cycle.Severe patient can in rest pain, cause Ipsilateral shoulder,
Axillary fossa, flank, back pain.
This disease sickness rate the most increasingly became younger in the trend risen year by year, age in the last few years.Treat in the market
The drug main of cyclomastopathy to have the Chinese patent medicines such as breast peaceful granule, GUIZHI FULING JIAONANG, PINGXIAO JIA0NANG, and these Chinese patent medicine specific aims are not
By force, even mostly be the medicine for the treatment of gynecological multiple disease treatment tumor, double cyclomastopathy of controlling, or just for cyclomastopathy
A certain symptom or a certain pathology link, and expensive.
Summary of the invention
It is an object of the invention to: for the problem of above-mentioned existence, it is provided that a kind of Chinese medicine composition treating cyclomastopathy
And preparation method thereof, treat cyclomastopathy by resolving depression eliminating stagnation, regulating blood circulation, the principle of the clear core of blood stasis dispelling, there is instant effect, treatment
The advantage imitate, having no side effect.
According to the theory of the traditional Chinese medical science, the clinical manifestation of different pattern of syndrome cyclomastopathies is: lump in breast, distending pain of the breast, agitation are easily
Anger, insomnia and dreamful sleep, costa sternales distension, bitter taste etc..Cyclomastopathy can be divided into caused by hepatic stagnation qi stagnation and the big class of disharmony of Chong and Conception Channels type two.Stagnation of liver-QI gas
Stagnant type cyclomastopathy preceeded menorrhea or breast swell and pain menstrual period, disappear with susceptible to anger, the string that side or bilateral can be laid one's hand on and differ in size
Pearl nodule, lump mostly is Semen phaseoli radiati big step nodule, or becomes the most streak, and matter is tough the hardest, presses movable, does not glues with deep tissue
Even, border is situated between unclear, and menstrual cycle is not enough, more through amount, heating installation uncomfortable in chest, spirit depressing, susceptible to lose temper due to restlessness.Disharmony of Chong and Conception Channels type mammary gland increases
There is lump in lactogenesis room, and premenstrual or pain in menstrual period increases the weight of, and alleviates or disappear after row, prolongs after menstrual period are many, and dysmenorrhoea is the most acute, hypomenorrhea,
Body is tired unable, soreness of waist cold extremities, few abdomen fear of cold, with the passing of time loses the person of controlling, and minority can occur canceration.
The Chinese medicine composition prescription of the present invention is developed according to the mechanism of above-mentioned caused by hepatic stagnation qi stagnation cyclomastopathy disease, is adopted
Technical scheme as follows:
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 15-30 part, ram's horn
Grass 5-10 part, Herba Salviae Chinensis 5-20 part, Rhizoma Pinelliae 3-11 part, Folium Symplocoris Caudatae 2-10 part, Cornu Cervi Degelatinatum 2-10 part, Caulis Spatholobi 10-15 part, Bulbus Allii Macrostemonis
10-15 part, Semen Momordicae 10-15 part, Fructus anethi 7-11 part, Semen Citri Reticulatae 9-21 part, Fructus Toosendan 10-30 part, Flos Rosae Rugosae 15-20 part, celestial being
Thatch 10-15 part, Retinervus Luffae Fructus 1-5 part, Fructus Liquidambaris 1-5 part.
Preferably, the Chinese medicine composition of above-mentioned treatment cyclomastopathy is made up of the raw material of following weight portion: Fructus Akebiae 20-
25 parts, Radix Ranunculi Ternati 6-9 part, Herba Salviae Chinensis 10-15 part, Rhizoma Pinelliae 6-8 part, Folium Symplocoris Caudatae 5-7 part, Cornu Cervi Degelatinatum 5-7 part, Caulis Spatholobi 11-14
Part, Bulbus Allii Macrostemonis 11-14 part, Semen Momordicae 11-14 part, Fructus anethi 8-10 part, Semen Citri Reticulatae 12-18 part, Fructus Toosendan 15-25 part, Flos Rosae Rugosae 16-
19 parts, Rhizoma Curculiginis 11-14 part, Retinervus Luffae Fructus 2-4 part, Fructus Liquidambaris 2-4 part.
It is highly preferred that the Chinese medicine composition of above-mentioned treatment cyclomastopathy is made up of the raw material of following weight portion: Fructus Akebiae
23 parts, Radix Ranunculi Ternati 8 parts, Herba Salviae Chinensis 13 parts, the Rhizoma Pinelliae 7 parts, Folium Symplocoris Caudatae 6 parts, Cornu Cervi Degelatinatum 6 parts, Caulis Spatholobi 12 parts, Bulbus Allii Macrostemonis 12 parts, wood
Trionyx sinensis Wiegmann 12 parts, Fructus anethi 9 parts, Semen Citri Reticulatae 15 parts, Fructus Toosendan 20 parts, Flos Rosae Rugosae 18 parts, Rhizoma Curculiginis 12 parts, Retinervus Luffae Fructus 3 parts, Fructus Liquidambaris 3
Part.
The preparation method of the Chinese medicine composition of above-mentioned treatment cyclomastopathy, comprises the following steps:
(1) Fructus Akebiae, Radix Ranunculi Ternati, Herba Salviae Chinensis addition are pulverized to bavin field formula pulverizer, cross 50-150 mesh, obtain medicated powder A；
(2) by the Rhizoma Pinelliae, Folium Symplocoris Caudatae, Cornu Cervi Degelatinatum, Caulis Spatholobi, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Semen Citri Reticulatae, Fructus Toosendan, Flos Rosae Rugosae, celestial being
Thatch, Retinervus Luffae Fructus, Fructus Liquidambaris boiling twice, merging filtrate, it is concentrated into relative density 1.10-1.20, adds ethanol and make containing alcohol
Amount reaches 50%, stands 24 hours, takes supernatant, obtain water extract B；
(3) by water extract B decompression recycling ethanol to without alcohol taste, continue to be condensed into thick paste, obtain paste C.
(4) medicated powder A is added in paste C, mix homogeneously, the Chinese medicine composition of the cyclomastopathy that can obtain medical treatment.
In the present invention, further illustrating, in step (1), the granularity of described pulverizing is 50-150 mesh.
In the present invention, further illustrating, in step (2), described decoction twice, the 1st time 2 hours, the 2nd time 1.5 little
Time.
The Chinese medicine composition of above-mentioned treatment cyclomastopathy can make medicament according to conventional pharmaceutical methods, the dosage form of medicament
Can be capsule or oral liquid.
The instructions of taking of this Chinese medicine composition is: daily three times, and point morning, noon and afternoon take, and within one month, are a course for the treatment of,
Take 1-3 the course for the treatment of.
The concrete effect of raw material of Chinese medicine employed in the present invention is as follows:
Fructus Akebiae, Chinese medicine name.For BENTONG section plant Caulis Akebiae, threeleaf akebia, the dry mature fruit of white BENTONG.8～JIUYUE between fruit
Pluck time ripe, or dry after soaking with boiling water.Sweet, cold.Return liver,spleen,kidney warp.Return liver,spleen,kidney warp.
Radix Ranunculi Ternati, for the tuber of cohosh ranunculus ternatus, because of its tuber meat, several bunches of lifes, nearly spindle, outer Beijing opera
Brown, is similar to ram's horn and gains the name.This platymiscium mostly is annual or perennial herb, and the whole world there are about kind more than 400, is widely distributed in cold temperature
Area, China has 78 kinds, 9 mutation, and main product is in various places, the middle and lower reach of Yangtze River, the most slightly poisonous, contributes to effect of detoxicating and resolving stagnation of pathogens.Remove
Outside Seynuns Kugelann is used as medicine with tuber, great majority, with all herbal medicine, are typically used as drawing red foaming, applying acupuncture point, can treat multiple disease, also
Can parasite killing.Sweet, acrid, warm.Modern pharmacology and clinical research show, Radix Ranunculi Ternati and preparation thereof are to pulmonary tuberculosis, lymphoid tuberculosis and multiple cancer
Disease and lymphoma are effective in cure, and meanwhile, ranunculus can act also as ornamental plant, have certain sight.The Rhizoma Pinelliae (formal name used at school:
Pinellia ternata), have another name called ground literary composition, keep field etc., belong to Arales.Be distributed widely in Yangtze River in China basin and northeast,
The areas such as North China.Medicinal plants, has drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, and the life furuncle and phyma effect that disappears, veterinary is in order to control cynanche Huang.?
Also there are distribution, height above sea level about 3000m in Tibet.For drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention is dizzy
Throbbing with fear, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.Folium Symplocoris Caudatae
Symplocos sumuntia, another name: Liu Chunshu, Radix Polygalae Wattersii.Sour and astringent micro-sweet, nontoxic.Attach to the lung and stomach meridians through.Heat-clearing and toxic substances removing；Convergence
Hemostasis.Main chronic dysentery；Wind-fire acute conjunctivitis, tonsillitis；Otitis media；Hemoptysis；Have blood in stool, thrush
Cornu Cervi Degelatinatum, for animal in deer family Cervus nippon Temminck Cervus nippon Temminck or Cervus elaphus linnaeus Cervus elaphus
The angle of Linnaeus etc. is remaining bone slag after boiling Colla cornus cervi.It is distributed in the ground such as Jilin, Liaoning, Heilungkiang, Shandong, Beijing.Tool
There is warming the kidney to activate YANG, effect of astringing to arrest bleeding.Being usually used in deficiency of spleen-YANG and kidneyYANG, leukorrhagia, enuresis frequent micturition, metrostaxis, skin infection is not held back
Treatment etc. disease.Salty in the mouth, puckery, warm in nature.Salty in the mouth, puckery, warm in nature.Caulis Spatholobi, for Schisandraceae, Sargentodoxaceae, Cuscutaceae, butterfly
The another name of the various plants such as Xing Hua section.Bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel；Red complexion enters blood, and matter profit row dissipates；Have and invigorate blood circulation
Relaxing muscles and tendons, effect of nourishing blood for regulating menstruation；
Bulbus Allii Macrostemonis, Latin literary fame: Allium macrostemon Bunge, another name Allium macrostemon, Bullbus Allii nipponici, bitter Bulbus Allii, little Bulbus Allii, rootlet
Dish, little root vegetables, big head, wild Bulbus Allii, Herba Allii prattii, open country.Belong to Liliaceae, allium.Li Shizhen (1518-1593 A.D.) is said: " its root is cooked, grain is hidden,
Vinegar leaching is all suitable ".Gen Sebai, makees medicinal, name Bulbus Allii Macrostemonis.Bulb is the most spherical, bulb outer belt black, and papery or film quality do not rupture, but
Many endotheliums only depositing white because coming off in specimen.Bulbus Allii Macrostemonis acrid in the mouth, hardship, warm in nature；Return stomach, large intestine, meridian of Hand-YANG MING；There is reason
Gas, the chest stuffiness relieving, activate yang, eliminating stagnation, effect of intestinal stasis relieving；Curing mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, weight, furuncle after dysentery.
Semen Momordicae, formal name used at school: Momordica cochinchinensis (Lour.) Spreng, another name: vomiting nut, glutinous meal
Really, mouse draws Fructus Benincasae etc..Perennial herbaceous stem rattan wood, the tuberous root that tool expands.Stem has vertical rib；Tendril is sturdy, with leaf to life, single
One, not branch.Leaf alternate, circular to wealthy the most avette, long 7-14 centimetre, usual 3 shallow split or drastic crack, and sliver is slightly in avette or long ovum
Shape, full edge or have micro-tooth, base portion is the most heart-shaped, the anxious point of tip, above smooth, below the little mastoid process of close life, 3 go out palmate net arteries and veins；Petiole
Long 5-10 centimetre, the vertical rib of tool, at middle part or nearly blade, have 2-5 body of gland.Flower unisexuality, hermaphroditism.Often it is born in height above sea level 450-
Gully, border and the roadside of 1100 meters.Wild in hillside, the deep place of soil layer of border.Like warm and sufficient sunlight.Crossing cloudy ring
Undergrowth under border.It is distributed in the Yangtze river basin and areas to the south, South East Asia Mainland and Indian peninsula also to have.There are dispersing swelling and dissipating binds, toxic removing
Effect.Nature and flavor are bitter, micro-sweet, cool；Poisonous.Return liver, spleen, stomach warp.
Fructus anethi, Latin literary fame: Anethum graveolens, another name: time U.S.-China, Fructus anethi green pepper, Fructus Foeniculi, shrivelled kernel fennel
Perfume, cumin, kind scheme are strangled.Acrid in the mouth, temperature, nontoxic.Enter spleen, kidney channel.Warming the spleen whets the appetite；Cold expelling warms up liver；Regulating QI to relieve pain.In abdomen cold
Bitterly；Side of body rib distension；Vomiting lack of appetite；Colic of cold type.
Semen Citri Reticulatae, for rutaceae orange Citrus reticulata Blanco and the drying and ripening kind of variety thereof
Son.Collect after fruit maturation, clean, dry.Bitter in the mouth, property is put down.Return liver, kidney channel.Regulate the flow of vital energy, eliminating stagnation, pain relieving.
Fructus Toosendan, Latin literary fame: MeliatoosendanSieb, another name: chinaberry reality, Fructus Toosendan, core Fructus Jujubae, Fructus Toosendan, chinaberry,
The stone Fructus Evodiae, Fructus Toosendan.Hardship, cold；Slightly poisonous.Return liver, small intestinal, bladder warp.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, gastral cavity abdominal distention
Bitterly, colic, abdominal pain due to worm stagnation.
Flos Rosae Rugosae, sweet and slightly bitter taste, warm in nature, the most obvious effect is regulated the flow of vital energy resolving depression, promoting blood circulation to remove blood stasis and menstruction regulating and pain relieving exactly.Additionally, medicine
By the property of medicine of Flos Rosae Rugosae as mild as a dove, it is possible to the conscience blood vessels of replenishing vital QI with drugs of warm nature people, relax and send out strongly fragrant gas internal, play halitosis, calmness, pacify,
Antidepressant effect.
Rhizoma Curculiginis, Latin literary fame: formal name used at school: Curculigo orchioides Gaertn, have another name called ground palm fibre (Sichuan, Guizhou), solely
Thatch, mountain Radix Codonopsis, Radix Scorzonerae Albicaulis, Radix Glehniae, thatch claw, tragopogon pratensis l., belong to Hypoxidaceae, florescence 4～JIUYUE.Bitter, puckery, flat.Medicinal plant
Thing, has reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and the effect of promoting the circulation of blood detumescence.
Retinervus Luffae Fructus is the vascular bundle of the mature fruit of cucurbitaceous plant Fructus Luffae or Guangdong Fructus Luffae." arteries and veins is because of card to have another name called a day trailing plants muscle
Control ", Fructus Luffae net " property of medicine is wanted in medical center bun ", Fructus Luffae shell " is classified herbal ", melon network, wadding melon pulp " Guangzhou flora ", sky sieve line
" medical material compilation of data ", vegetable sponge " Jiangsu Province's vegetable drug will ", chalina " Hebei medical material ", Hypericum perforatum L. " Hunan medicine will ",
Fructus Luffae cloth " Chinese herbal medicine is commonly used in Sichuan ".Gan Xingping, enters lung, stomach, Liver Channel, and former plant Guangdong Fructus Luffae has another name called: patola.Stimulate the menstrual flow work
Network, effect of removing toxic substances and promoting subsidence of swelling.
Fructus Liquidambaris, for the drying and ripening fruit of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance
Sequence.Winter gathers after fruit maturation, removes impurity, is dried.Bitter in the mouth, property is put down.Liver, kidney channel.There are dispelling, collateral-activating, diuretic, stimulate the menstrual flow
Effect.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:
The prescription of the present invention, scientific and reasonable compatibility, be for treatment caused by hepatic stagnation qi stagnation cyclomastopathy and develop, side in Fructus Akebiae,
Flos Rosae Rugosae has soothing liver-QI for relieving depression, effect of pain relieving；Radix Ranunculi Ternati, the Rhizoma Pinelliae have powder detoxifcation, the effect of removing heat-phlegm；Cornu Cervi Degelatinatum, Sanguis Gallus domesticus
Rattan, Herba Salviae Chinensis, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Fructus Toosendan have liver-smoothing, qi-regulating, promoting blood circulation to remove blood stasis, effect of dispersing cold for relieving pain；Folium Symplocoris Caudatae,
Semen Citri Reticulatae and Fructus Liquidambaris have heat-clearing and toxic substances removing, effect of reconciling superficies and interior；Rhizoma Curculiginis, Retinervus Luffae Fructus have clearing away heat and promoting diuresis, the effect invigorated blood circulation.All medicines close
With, play altogether resolving depression eliminating stagnation, regulating blood circulation, the clear core of blood stasis dispelling principle to treat cyclomastopathy, there is instant effect, good effect, nontoxic
The advantage of side effect.Achieve obvious clinical effectiveness by clinic application, be used for treating caused by hepatic stagnation qi stagnation cyclomastopathy, the most effectively
Rate reaches 93.3%, without obvious toxic-side effects.
[detailed description of the invention]
The invention provides a kind of Chinese medicine composition treating cyclomastopathy, be made up of the raw material of following weight portion: Fructus Akebiae 15-
30 parts, Radix Ranunculi Ternati 5-10 part, Herba Salviae Chinensis 5-20 part, Rhizoma Pinelliae 3-11 part, Folium Symplocoris Caudatae 2-10 part, Cornu Cervi Degelatinatum 2-10 part, Caulis Spatholobi 10-
15 parts, Bulbus Allii Macrostemonis 10-15 part, Semen Momordicae 10-15 part, Fructus anethi 7-11 part, Semen Citri Reticulatae 9-21 part, Fructus Toosendan 10-30 part, Flos Rosae Rugosae
15-20 part, Rhizoma Curculiginis 10-15 part, Retinervus Luffae Fructus 1-5 part, Fructus Liquidambaris 1-5 part.Kinds of traditional Chinese medicines complements each other, and plays resolving depression eliminating stagnation, tune altogether
With passages through which vital energy circulates, the merit of the clear core of blood stasis dispelling, and then the effective state of an illness controlling caused by hepatic stagnation qi stagnation cyclomastopathy.Below by way of specific embodiment
The invention will be further described.
Embodiment 1
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 15g, Radix Ranunculi Ternati 5g,
Herba Salviae Chinensis 5g, Rhizoma Pinelliae 3g, Folium Symplocoris Caudatae 2g, Cornu Cervi Degelatinatum 2g, Caulis Spatholobi 10g, Bulbus Allii Macrostemonis 10g, Semen Momordicae 10g, Fructus anethi 7g, Semen Citri Reticulatae
9g, Fructus Toosendan 10g, Flos Rosae Rugosae 15g, Rhizoma Curculiginis 10g, Retinervus Luffae Fructus 1g, Fructus Liquidambaris 1g.
Following method is used to prepare this Chinese medicine composition:
(1) Fructus Akebiae, Radix Ranunculi Ternati, Herba Salviae Chinensis addition are pulverized to bavin field formula pulverizer, cross 100 mesh, obtain medicated powder A；
(2) by the Rhizoma Pinelliae, Folium Symplocoris Caudatae, Cornu Cervi Degelatinatum, Caulis Spatholobi, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Semen Citri Reticulatae, Fructus Toosendan, Flos Rosae Rugosae, celestial being
Thatch, Retinervus Luffae Fructus, Fructus Liquidambaris boiling twice, merging filtrate, it is concentrated into relative density 1.15, adds ethanol and make alcohol content reach
50%, stand 24 hours, take supernatant, obtain water extract B；
(3) by water extract B decompression recycling ethanol to without alcohol taste, continue to be condensed into thick paste, obtain paste C.
(4) medicated powder A is added in paste C, mix homogeneously, the Chinese medicine composition of the cyclomastopathy that can obtain medical treatment.
Embodiment 2
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 20g, Radix Ranunculi Ternati 6g,
Herba Salviae Chinensis 10g, Rhizoma Pinelliae 6g, Folium Symplocoris Caudatae 5g, Cornu Cervi Degelatinatum 5g, Caulis Spatholobi 11g, Bulbus Allii Macrostemonis 11g, Semen Momordicae 11g, Fructus anethi 8g, Semen Citri Reticulatae
12g, Fructus Toosendan 15g, Flos Rosae Rugosae 16g, Rhizoma Curculiginis 11g, Retinervus Luffae Fructus 2g, Fructus Liquidambaris 2g.
Following method is used to prepare this Chinese medicine composition:
(1) Fructus Akebiae, Radix Ranunculi Ternati, Herba Salviae Chinensis addition are pulverized to bavin field formula pulverizer, cross 150 mesh, obtain medicated powder A；
(2) by the Rhizoma Pinelliae, Folium Symplocoris Caudatae, Cornu Cervi Degelatinatum, Caulis Spatholobi, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Semen Citri Reticulatae, Fructus Toosendan, Flos Rosae Rugosae, celestial being
Thatch, Retinervus Luffae Fructus, Fructus Liquidambaris boiling twice, merging filtrate, it is concentrated into relative density 1.20, adds ethanol and make alcohol content reach
50%, stand 24 hours, take supernatant, obtain water extract B；
(3) by water extract B decompression recycling ethanol to without alcohol taste, continue to be condensed into thick paste, obtain paste C.
(4) medicated powder A is added in paste C, mix homogeneously, the Chinese medicine composition of the cyclomastopathy that can obtain medical treatment.
Embodiment 3
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 23g, Radix Ranunculi Ternati 8g,
Herba Salviae Chinensis 13g, Rhizoma Pinelliae 7g, Folium Symplocoris Caudatae 6g, Cornu Cervi Degelatinatum 6g, Caulis Spatholobi 12g, Bulbus Allii Macrostemonis 12g, Semen Momordicae 12g, Fructus anethi 9g, Semen Citri Reticulatae
15g, Fructus Toosendan 20g, Flos Rosae Rugosae 18g, Rhizoma Curculiginis 12g, Retinervus Luffae Fructus 3g, Fructus Liquidambaris 3g.
Following method is used to prepare this Chinese medicine composition:
(1) Fructus Akebiae, Radix Ranunculi Ternati, Herba Salviae Chinensis addition are pulverized to bavin field formula pulverizer, cross 50 mesh, obtain medicated powder A；
(2) by the Rhizoma Pinelliae, Folium Symplocoris Caudatae, Cornu Cervi Degelatinatum, Caulis Spatholobi, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Semen Citri Reticulatae, Fructus Toosendan, Flos Rosae Rugosae, celestial being
Thatch, Retinervus Luffae Fructus, Fructus Liquidambaris boiling twice, merging filtrate, it is concentrated into relative density 1.10, adds ethanol and make alcohol content reach
50%, stand 24 hours, take supernatant, obtain water extract B；
(3) by water extract B decompression recycling ethanol to without alcohol taste, continue to be condensed into thick paste, obtain paste C.
(4) medicated powder A is added in paste C, mix homogeneously, the Chinese medicine composition of the cyclomastopathy that can obtain medical treatment.
Embodiment 4
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 30g, Radix Ranunculi Ternati
10g, Herba Salviae Chinensis 20g, Rhizoma Pinelliae 11g, Folium Symplocoris Caudatae 10g, Cornu Cervi Degelatinatum 10g, Caulis Spatholobi 15g, Bulbus Allii Macrostemonis 15g, Semen Momordicae 15g, Fructus anethi
11g, Semen Citri Reticulatae 21g, Fructus Toosendan 30g, Flos Rosae Rugosae 20g, Rhizoma Curculiginis 15g, Retinervus Luffae Fructus 5g, Fructus Liquidambaris 5g.
The method identical with embodiment 3 is used to prepare this Chinese medicine composition.
Embodiment 5
A kind of Chinese medicine composition treating cyclomastopathy, is made up of the raw material of following weight portion: Fructus Akebiae 25g, Radix Ranunculi Ternati 9g,
Herba Salviae Chinensis 15g, Rhizoma Pinelliae 8g, Folium Symplocoris Caudatae 7g, Cornu Cervi Degelatinatum 7g, Caulis Spatholobi 14g, Bulbus Allii Macrostemonis 14g, Semen Momordicae 14g, Fructus anethi 10g, Semen Citri Reticulatae
18g, Fructus Toosendan 25g, Flos Rosae Rugosae 19g, Rhizoma Curculiginis 14g, Retinervus Luffae Fructus 4g, Fructus Liquidambaris 4g.
The method identical with embodiment 3 is used to prepare this Chinese medicine composition.
In order to observe the clinical efficacy of present composition treatment cyclomastopathy, the present invention is carried out concept clinical sight
Examine, now clinical test results be reported as follows:
(1) object of observation: during in January, 2016-June, uses the Chinese medicine composition of the present invention to treat 60 example patients altogether, unilateral
Cyclomastopathy 32 example, bilateral breast falls ill 28 examples, age 25-40 year, 30 years old mean age, the course of disease 2 months-2 years, average 13
Month.
(2) diagnostic criteria: lump in breast, distending pain of the breast, irritable, insomnia and dreamful sleep, costa sternales distension, bitter taste etc..
(3) Therapeutic Method: arbitrary Chinese medicine composition made in oral embodiment of the present invention 1-5, daily three times, point
Morning, noon and afternoon take, and within one month, are a course for the treatment of, take 1-3 the course for the treatment of, follow up a case by regular visits to after 3 months, add up recurrence.
(4) the standard of curative effect evaluation:
1. recovery from illness: distending pain of the breast and lump disappear, takes the photograph sheet inspection in conjunction with breast molybdenum target and confirms that cyclomastopathy sign disappears.Drug withdrawal
Within latter 3 months, do not recur.
The most effective: in breast, lump disappears, quality deliquescing, pain disappears, and ultrasonic examination prompting shadow disappears, near-infrared
Ray examination is normal breast image.
The most effective: distending pain of the breast alleviates, physical palpation mass reduction 2/3, breast molybdenum target is taken the photograph sheet inspection and is confirmed cyclomastopathy
Take a turn for the better, be substantially consistent with clinical symptoms and palpation.
The most invalid: distending pain of the breast is not improved compared with before treatment with lump, and breast molybdenum target take the photograph sheet inspection confirm.
(5) therapeutic outcome: in 60 example cases, through 1-3 course of therapy, wherein cures 29 examples, effective 15 examples, and effective 12
Example, invalid 4 examples, total effective rate 93.3%, the course for the treatment of is the shortest 30 days, the longest 150 days, follows up a case by regular visits to 1 year have no recurrence.
Model case:
Deep so-and-so, 38 years old, female, the course of disease 3 months, lump in breast, distending pain of the breast, insomnia and dreamful sleep, costa sternales distension, bitter taste, take reality
The Chinese medicine composition executing example 1 takes effect January, and 3 courses for the treatment of cure.
Liu, 27 years old, female, the course of disease 1 year, breast had that lump, lump be relatively big, irritability, insomnia and dreamful sleep, distending pain of the breast, takes
The Chinese medicine composition of embodiment 1 takes effect January, within 1 year, cures.
Described above is the detailed description for the preferable possible embodiments of the present invention, but embodiment is not limited to this
Bright patent claim, the equal change completed under the technical spirit suggested by all present invention or modification change, all should belong to
In the contained the scope of the claims of the present invention.
Claims (6)
1. the Chinese medicine composition treating cyclomastopathy, it is characterised in that: it is made up of the raw material of following weight portion: Fructus Akebiae
15-30 part, Radix Ranunculi Ternati 5-10 part, Herba Salviae Chinensis 5-20 part, Rhizoma Pinelliae 3-11 part, Folium Symplocoris Caudatae 2-10 part, Cornu Cervi Degelatinatum 2-10 part, Caulis Spatholobi
10-15 part, Bulbus Allii Macrostemonis 10-15 part, Semen Momordicae 10-15 part, Fructus anethi 7-11 part, Semen Citri Reticulatae 9-21 part, Fructus Toosendan 10-30 part, Flos Rosae Rugosae
Flower 15-20 part, Rhizoma Curculiginis 10-15 part, Retinervus Luffae Fructus 1-5 part, Fructus Liquidambaris 1-5 part.
A kind of Chinese medicine composition treating cyclomastopathy the most according to claim 1, it is characterised in that: by following weight portion
Raw material make: Fructus Akebiae 20-25 part, Radix Ranunculi Ternati 6-9 part, Herba Salviae Chinensis 10-15 part, Rhizoma Pinelliae 6-8 part, Folium Symplocoris Caudatae 5-7 part, Cornu Cervi
Frost 5-7 part, Caulis Spatholobi 11-14 part, Bulbus Allii Macrostemonis 11-14 part, Semen Momordicae 11-14 part, Fructus anethi 8-10 part, Semen Citri Reticulatae 12-18 part, Fructus Toosendan
Sub-15-25 part, Flos Rosae Rugosae 16-19 part, Rhizoma Curculiginis 11-14 part, Retinervus Luffae Fructus 2-4 part, Fructus Liquidambaris 2-4 part.
A kind of Chinese medicine composition treating cyclomastopathy the most according to claim 1, it is characterised in that: by following weight portion
Raw material make: Fructus Akebiae 23 parts, Radix Ranunculi Ternati 8 parts, Herba Salviae Chinensis 13 parts, the Rhizoma Pinelliae 7 parts, Folium Symplocoris Caudatae 6 parts, Cornu Cervi Degelatinatum 6 parts, Caulis Spatholobi
12 parts, Bulbus Allii Macrostemonis 12 parts, Semen Momordicae 12 parts, Fructus anethi 9 parts, Semen Citri Reticulatae 15 parts, Fructus Toosendan 20 parts, Flos Rosae Rugosae 18 parts, Rhizoma Curculiginis 12 part, thread
Melon network 3 parts, Fructus Liquidambaris 3 parts.
4., according to the preparation method of a kind of Chinese medicine composition treating cyclomastopathy described in claim 1,2 or 3, its feature exists
In: comprise the following steps:
(1) Fructus Akebiae, Radix Ranunculi Ternati, Herba Salviae Chinensis addition are pulverized to bavin field formula pulverizer, cross 50-150 mesh, obtain medicated powder A；
(2) by the Rhizoma Pinelliae, Folium Symplocoris Caudatae, Cornu Cervi Degelatinatum, Caulis Spatholobi, Bulbus Allii Macrostemonis, Semen Momordicae, Fructus anethi, Semen Citri Reticulatae, Fructus Toosendan, Flos Rosae Rugosae, celestial being
Thatch, Retinervus Luffae Fructus, Fructus Liquidambaris boiling twice, merging filtrate, it is concentrated into relative density 1.10-1.20, adds ethanol and make containing alcohol
Amount reaches 50%, stands 24 hours, takes supernatant, obtain water extract B；
(3) by water extract B decompression recycling ethanol to without alcohol taste, continue to be condensed into thick paste, obtain paste C；
(4) medicated powder A is added in paste C, mix homogeneously, the Chinese medicine composition of the cyclomastopathy that can obtain medical treatment.
The preparation method of a kind of Chinese medicine composition treating cyclomastopathy the most according to claim 4, it is characterised in that:
In step (1), the granularity of described pulverizing is 50-150 mesh.
The preparation method of a kind of Chinese medicine composition treating cyclomastopathy the most according to claim 4, it is characterised in that:
In step (2), described decoction twice, the 1st time 2 hours, the 2nd time 1.5 hours.
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