CN106177727A - A kind of pharmaceutical composition the most smooth for vein haemospasia - Google Patents

A kind of pharmaceutical composition the most smooth for vein haemospasia Download PDF

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Publication number
CN106177727A
CN106177727A CN201610686853.4A CN201610686853A CN106177727A CN 106177727 A CN106177727 A CN 106177727A CN 201610686853 A CN201610686853 A CN 201610686853A CN 106177727 A CN106177727 A CN 106177727A
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pharmaceutical composition
parts
standby
fine powder
mentholum
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冯智慧
刘丽
胡彬
迟晓云
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Qingdao Blood Center
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Qingdao Blood Center
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Abstract

The present invention relates to a kind of pharmaceutical composition the most smooth for vein haemospasia and preparation method thereof, this pharmaceutical composition is made up of the medicine of following weight portion: Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi, Scolopendra, Venenum Bufonis, Rhizoma Drynariae, Fructus Amomi Rotundus, Mentholum, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum, pass through alcohol extraction, the techniques such as water carries are made, for not smooth patient 270 example of vein haemospasia, total effective rate reaches 98.2%, effect is obvious, and do not find untoward reaction and toxic and side effects, illustrate that pharmaceutical composition of the present invention is evident in efficacy for the not smooth patient's aspect of vein haemospasia, there is good promotional value.

Description

A kind of pharmaceutical composition the most smooth for vein haemospasia
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of pharmaceutical composition the most smooth for vein haemospasia and system thereof Preparation Method.
Background technology
Vein haemospasia is a kind of operation being frequently encountered by hospital or when donating blood, and the position of general blood drawing has upper limb quiet Arteries and veins, including hand and the vein of arm, veins of lower extremity, operates at scalp vein for infant is many, although vein haemospasia Simple to operate, but run into anemia, hypotensive patient blood and be just not easy to extract out, carry puzzlement to medical personnel and patient, because of This helps medical personnel to carry out drawing blood by medicine is necessary.
The present invention is contemplated to solve blood drawing difficulty and have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition the most smooth for vein haemospasia.
It is a further object of the present invention to provide the preparation method of a kind of pharmaceutical composition the most smooth for vein haemospasia.
The present invention provides a kind of pharmaceutical composition the most smooth for vein haemospasia, and this pharmaceutical composition is by following weight portion Medicine is made: Caulis Lonicerae 10-30 part, Cinnabaris 5-15 part, Herba Epimedii 20-50 part, Herba Plantaginis 10-40 part, Fructus Crataegi 10-40 part, Wu Centipede 5-15 part, Venenum Bufonis 5-15 part, Rhizoma Drynariae 15-40 part, Fructus Amomi Rotundus 10-30 part, Mentholum 10-30 part, Semen Ziziphi Spinosae 10-25 part, heavy Fragrant 10-30 part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Caulis Lonicerae 12-28 part, Zhu Sand 7-13 part, Herba Epimedii 25-45 part, Herba Plantaginis 15-35 part, Fructus Crataegi 15-35 part, Scolopendra 7-13 part, Venenum Bufonis 7-13 part, Rhizoma Drynariae 20-35 part, Fructus Amomi Rotundus 13-27 part, Mentholum 13-27 part, Semen Ziziphi Spinosae 12-22 part, Lignum Aquilariae Resinatum 13-27 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Caulis Lonicerae 15-26 Part, Cinnabaris 8-12 part, Herba Epimedii 28-42 part, Herba Plantaginis 18-32 part, Fructus Crataegi 18-32 part, Scolopendra 8-12 part, Venenum Bufonis 8-12 part, Rhizoma Drynariae 23-32 part, Fructus Amomi Rotundus 15-25 part, Mentholum 15-25 part, Semen Ziziphi Spinosae 15-20 part, Lignum Aquilariae Resinatum 15-25 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Caulis Lonicerae 17- 24 parts, Cinnabaris 9-11 part, Herba Epimedii 32-38 part, Herba Plantaginis 22-28 part, Fructus Crataegi 22-28 part, Scolopendra 9-11 part, Venenum Bufonis 9-11 Part, Rhizoma Drynariae 25-28 part, Fructus Amomi Rotundus 17-22 part, Mentholum 18-22 part, Semen Ziziphi Spinosae 16-19 part, Lignum Aquilariae Resinatum 18-22 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Caulis Lonicerae 20 Part, 10 parts of Cinnabaris, Herba Epimedii 35 parts, Herba Plantaginis 25 parts, Fructus Crataegi 25 parts, Scolopendra 10 parts, Venenum Bufonis 10 parts, Rhizoma Drynariae 27 parts, Fructus Amomi Rotundus 18 parts, Mentholum 20 parts, Semen Ziziphi Spinosae 18 parts, Lignum Aquilariae Resinatum 20 parts.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is liquid preparation；Described liquid preparation is spray.
The preparation method of pharmaceutical composition of the present invention comprises the following steps: Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi, Scolopendra, Venenum Bufonis, Rhizoma Drynariae, Fructus Amomi Rotundus, Mentholum, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum pulverize and sieve, with pharmaceutically acceptable carrier or Diluent mix homogeneously, is prepared as preparation.
The preparation method of pharmaceutical composition of the present invention comprises the following steps:
1) Scolopendra, Venenum Bufonis slow fire are fried 10-30 minute, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 1-3 times amount water soaking 2-5 hour, filter, filtrate is dense Contracting dry, pulverize into fine powder, standby；Filtering residue adds soak with ethanol 1-3 hour of 75%, filters, filtrate concentrate drying, is ground into Fine powder, standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 2-4 times amount soak by water 2 times, collecting decoction, to filter, filtrate is dense Contracting dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Preferably, the preparation method of pharmaceutical composition of the present invention comprises the following steps:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, selected from filler, One or more in binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or Portugal Grape sugar etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber Element or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or stearic acid Magnesium；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fat Fat acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method have the advantages that
For smooth patient 270 example of vein haemospasia, total effective rate reaches 98.2%, and effect is obvious, and do not find bad instead Should illustrate that pharmaceutical composition of the present invention is evident in efficacy for the not smooth patient's aspect of vein haemospasia with toxic and side effects, have and well push away Wide value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Caulis Lonicerae 10g, Cinnabaris 5g, Herba Epimedii 20g, Herba Plantaginis 10g, Fructus Crataegi 10g, Scolopendra 5g, Venenum Bufonis 5g, osteomiosis Mend 15g, Fructus Amomi Rotundus 10g, Mentholum 10g, Semen Ziziphi Spinosae 10g, Lignum Aquilariae Resinatum 10g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 10 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 1 times amount water soaking 2 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 1 hour, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 2 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 2
Prescription: Caulis Lonicerae 30g, Cinnabaris 15g, Herba Epimedii 50g, Herba Plantaginis 40g, Fructus Crataegi 40g, Scolopendra 15g, Venenum Bufonis 15g, bone Broken benefit 40g, Fructus Amomi Rotundus 30g, Mentholum 30g, Semen Ziziphi Spinosae 25g, Lignum Aquilariae Resinatum 30g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 30 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 3 times amount water soaking 5 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 3 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 4 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 3
Prescription: Caulis Lonicerae 12g, Cinnabaris 7g, Herba Epimedii 25g, Herba Plantaginis 15g, Fructus Crataegi 15g, Scolopendra 7g, Venenum Bufonis 7g, osteomiosis Mend 20g, Fructus Amomi Rotundus 13g, Mentholum 13g, Semen Ziziphi Spinosae 12g, Lignum Aquilariae Resinatum 13g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 15 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 4
Prescription: Caulis Lonicerae 28g, Cinnabaris 13g, Herba Epimedii 45g, Herba Plantaginis 35g, Fructus Crataegi 35g, Scolopendra 13g, Venenum Bufonis 13g, bone Broken benefit 35g, Fructus Amomi Rotundus 27g, Mentholum 27g, Semen Ziziphi Spinosae 22g, Lignum Aquilariae Resinatum 27g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 25 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 4 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 5
Prescription: Caulis Lonicerae 15g, Cinnabaris 8g, Herba Epimedii 28g, Herba Plantaginis 18g, Fructus Crataegi 18g, Scolopendra 8g, Venenum Bufonis 8g, osteomiosis Mend 23g, Fructus Amomi Rotundus 15g, Mentholum 15g, Semen Ziziphi Spinosae 15g, Lignum Aquilariae Resinatum 15g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 6
Prescription: Caulis Lonicerae 26g, Cinnabaris 12g, Herba Epimedii 42g, Herba Plantaginis 32g, Fructus Crataegi 32g, Scolopendra 12g, Venenum Bufonis 12g, bone Broken benefit 32g, Fructus Amomi Rotundus 25g, Mentholum 25g, Semen Ziziphi Spinosae 20g, Lignum Aquilariae Resinatum 25g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 7
Prescription: Caulis Lonicerae 17g, Cinnabaris 9g, Herba Epimedii 32g, Herba Plantaginis 22g, Fructus Crataegi 22g, Scolopendra 9g, Venenum Bufonis 9g, osteomiosis Mend 25g, Fructus Amomi Rotundus 17g, Mentholum 18g, Semen Ziziphi Spinosae 16g, Lignum Aquilariae Resinatum 18g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 8
Prescription: Caulis Lonicerae 24g, Cinnabaris 11g, Herba Epimedii 38g, Herba Plantaginis 28g, Fructus Crataegi 28g, Scolopendra 11g, Venenum Bufonis 11g, bone Broken benefit 28g, Fructus Amomi Rotundus 22g, Mentholum 22g, Semen Ziziphi Spinosae 19g, Lignum Aquilariae Resinatum 22g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
Embodiment 9
Prescription: Caulis Lonicerae 20g, Cinnabaris 10g, Herba Epimedii 35g, Herba Plantaginis 25g, Fructus Crataegi 25g, Scolopendra 10g, Venenum Bufonis 10g, bone Broken benefit 27g, Fructus Amomi Rotundus 18g, Mentholum 20g, Semen Ziziphi Spinosae 18g, Lignum Aquilariae Resinatum 20g.
Preparation method:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 2 times amount water soaking 3 hours, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, Standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates Dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 little Time, merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
In order to sketch beneficial effects of the present invention further, inventor has done clinical trial, specific as follows:
Patient is presented herein below and uses the clinical statistics data of medicine of the present invention:
One, physical data accepts patient 270 example, wherein male 110 example, women 160 example, 52 years old mean age for medical treatment.
Two, method:
Patient is divided into 9 groups, uses the pharmaceutical composition of embodiment of the present invention 1-9 respectively, be sprayed onto uniformly and need blood drawing Position.
Three, efficacy assessment standard:
1, effective: the venous blood of patient was extracted out in 3 minutes by medication smoothly.
2, effective: the venous blood of patient was extracted out in 6 minutes by medication smoothly.
3, invalid: medication can not taken out more than more than 10 minutes.
Four, result statistical table
Group Effective Effectively Invalid Add up to Effective percentage (%)
Embodiment 1 25 4 1 30 96.7%
Embodiment 2 24 6 0 30 100%
Embodiment 3 26 4 0 30 100%
Embodiment 4 23 6 1 30 96.7%
Embodiment 5 25 5 0 30 100%
Embodiment 6 26 3 1 30 96.7%
Embodiment 7 25 4 1 30 96.7%
Embodiment 8 24 5 1 30 96.7%
Embodiment 9 27 3 0 30 100%
For smooth patient 270 example of vein haemospasia, total effective rate reaches 98.2%, and effect is obvious, and do not find bad instead Should illustrate that pharmaceutical composition of the present invention is evident in efficacy for the not smooth patient's aspect of vein haemospasia with toxic and side effects, have and well push away Wide value.
Model case:
Case one, patient Tan, man, 52 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 1 Medicine, drew blood after 1 minute, and blood can smooth and easy extraction.
Case two, patient Xiao, female, 56 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 2 Medicine, drew blood after 5 minutes, and blood can smooth and easy extraction.
Case three, patient Korea Spro, man, 57 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 3 Medicine, drew blood after 3 minutes, and blood can smooth and easy extraction.
Case four, patient shut out certain, man, 50 years old, and blood drawing of donating blood uses multiple method can not take out, therefore uses the present embodiment 4 Medicine, drew blood after 4 minutes, and blood can smooth and easy extraction.
Case five, patient Lee, female, 52 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 5 Medicine, drew blood after 2 minutes, and blood can smooth and easy extraction.
Case six, patient's summer, female, 46 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 6 Medicine, drew blood after 3 minutes, and blood can smooth and easy extraction.
Case seven, patient field, man, 60 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 7 Medicine, drew blood after 2 minutes, and blood can smooth and easy extraction.
Case eight, patient Jiang, female, blood drawing of donating blood, use multiple method can not take out, therefore use the medicine of the present embodiment 8, Drawing blood after 5 minutes, blood can smooth and easy extraction.
Case nine, Guo patient, female, 52 years old, blood drawing of donating blood, use multiple method can not take out, therefore use the present embodiment 9 Medicine, drew blood after 2 minutes, and blood can smooth and easy extraction.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching Stating, but on the basis of the present invention, it can be made some amendments or improve, this is aobvious and easy to those skilled in the art See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed Scope.

Claims (10)

1. one kind is used for the pharmaceutical composition that vein haemospasia is the most smooth, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion Thing is made: Caulis Lonicerae 10-30 part, Cinnabaris 5-15 part, Herba Epimedii 20-50 part, Herba Plantaginis 10-40 part, Fructus Crataegi 10-40 part, Scolopendra 5-15 part, Venenum Bufonis 5-15 part, Rhizoma Drynariae 15-40 part, Fructus Amomi Rotundus 10-30 part, Mentholum 10-30 part, Semen Ziziphi Spinosae 10-25 part, Lignum Aquilariae Resinatum 10-30 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion Make: Caulis Lonicerae 12-28 part, Cinnabaris 7-13 part, Herba Epimedii 25-45 part, Herba Plantaginis 15-35 part, Fructus Crataegi 15-35 part, Scolopendra 7- 13 parts, Venenum Bufonis 7-13 part, Rhizoma Drynariae 20-35 part, Fructus Amomi Rotundus 13-27 part, Mentholum 13-27 part, Semen Ziziphi Spinosae 12-22 part, Lignum Aquilariae Resinatum 13- 27 parts.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion Make: Caulis Lonicerae 15-26 part, Cinnabaris 8-12 part, Herba Epimedii 28-42 part, Herba Plantaginis 18-32 part, Fructus Crataegi 18-32 part, Scolopendra 8- 12 parts, Venenum Bufonis 8-12 part, Rhizoma Drynariae 23-32 part, Fructus Amomi Rotundus 15-25 part, Mentholum 15-25 part, Semen Ziziphi Spinosae 15-20 part, Lignum Aquilariae Resinatum 15- 25 parts.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion Make: Caulis Lonicerae 17-24 part, Cinnabaris 9-11 part, Herba Epimedii 32-38 part, Herba Plantaginis 22-28 part, Fructus Crataegi 22-28 part, Scolopendra 9- 11 parts, Venenum Bufonis 9-11 part, Rhizoma Drynariae 25-28 part, Fructus Amomi Rotundus 17-22 part, Mentholum 18-22 part, Semen Ziziphi Spinosae 16-19 part, Lignum Aquilariae Resinatum 18- 22 parts.
Pharmaceutical composition the most according to claim 4, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion Make: Caulis Lonicerae 20 parts, 10 parts of Cinnabaris, Herba Epimedii 35 parts, Herba Plantaginis 25 parts, Fructus Crataegi 25 parts, Scolopendra 10 parts, Venenum Bufonis 10 parts, bone Broken benefit 27 parts, 18 parts of Fructus Amomi Rotundus, Mentholum 20 parts, Semen Ziziphi Spinosae 18 parts, Lignum Aquilariae Resinatum 20 parts.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this pharmaceutical composition is possibly together with pharmacy Upper acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition is liquid preparation；Described Liquid preparation is spray.
8. the method for the pharmaceutical composition prepared described in any one of claim 1-5, it is characterised in that the method include with Lower step: Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi, Scolopendra, Venenum Bufonis, Rhizoma Drynariae, Fructus Amomi Rotundus, Mentholum, Semen Ziziphi Spinosae, heavy Perfume (or spice) pulverizes and sieves, and mixs homogeneously with pharmaceutically acceptable carrier or diluent, is prepared as preparation.
9. prepare the method for pharmaceutical composition described in any one of claim 1-5 for one kind, it is characterised in that the method includes following Step:
1) Scolopendra, Venenum Bufonis slow fire are fried 10-30 minute, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi being added 1-3 times amount water soaking 2-5 hour, filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；Filtering residue adds soak with ethanol 1-3 hour of 75%, filters, filtrate concentrate drying, is ground into thin Powder, standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 2-4 times amount soak by water 2 times, collecting decoction, to filter, filtrate concentrates dry Dry, it is ground into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 hours, Merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that the method comprises the following steps:
1) Scolopendra, Venenum Bufonis slow fire are fried 20 minutes, be ground into fine powder standby；
2) Caulis Lonicerae, Cinnabaris, Herba Epimedii, Herba Plantaginis, Fructus Crataegi are added 2 times amount water soaking 3 hours, filter, filtrate concentrate drying, powder It is broken into fine powder, standby；The soak with ethanol of filtering residue addition 75% 2 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
3) Rhizoma Drynariae, Fructus Amomi Rotundus, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are added 3 times amount soak by water 2 times, collecting decoction, filter, filtrate concentrate drying, It is ground into fine powder, standby；
4) above-mentioned standby fine powder is mixed homogeneously with Mentholum, add by 4 times amount 75% alcohol dipping 2 times, each 3 hours, Merge impregnation liquid, filter, stir, airtight, stand 12 hours, in filling device spray bottle, obtain spray.
CN201610686853.4A 2016-08-05 2016-08-05 A kind of pharmaceutical composition the most smooth for vein haemospasia Pending CN106177727A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390594A (en) * 2002-07-30 2003-01-15 成都国嘉药物研究所 Mixture for improving blood circulation
CN1785383A (en) * 2005-11-10 2006-06-14 贵州益佰制药股份有限公司 Medicinal preparation for treating embolus and its preparation method
CN1876146A (en) * 2005-06-10 2006-12-13 李东坡 A Chinese medicine for treating cardiovascular and cerebrovascular disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390594A (en) * 2002-07-30 2003-01-15 成都国嘉药物研究所 Mixture for improving blood circulation
CN1876146A (en) * 2005-06-10 2006-12-13 李东坡 A Chinese medicine for treating cardiovascular and cerebrovascular disease
CN1785383A (en) * 2005-11-10 2006-06-14 贵州益佰制药股份有限公司 Medicinal preparation for treating embolus and its preparation method

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Application publication date: 20161207