CN106177705B - Anti-stress traditional Chinese veterinary medicine feed additive capable of improving production performance and preparation method thereof - Google Patents
Anti-stress traditional Chinese veterinary medicine feed additive capable of improving production performance and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese veterinary medicine feed additive with anti-stress and production performance improving functions and a preparation method thereof, wherein the traditional Chinese veterinary medicine feed additive comprises the following raw material medicines in parts by weight: 5-10 parts of campanumoea, 5-10 parts of Chinese yam, 5-10 parts of red yeast rice, 1-5 parts of galangal, 10-30 parts of epimedium, 5-15 parts of poria cocos and 5-15 parts of liquorice; the preparation process comprises the following steps: pulverizing and mixing the traditional Chinese medicines, and fermenting the traditional Chinese medicines by microorganisms. The traditional Chinese veterinary medicine feed additive can reduce the stress reaction of livestock and poultry, promote the ingestion, improve the utilization rate of the feed and improve the production performance of the livestock and poultry.
Description
Technical Field
The invention relates to a traditional Chinese veterinary medicine feed additive for livestock and poultry, in particular to a traditional Chinese veterinary medicine feed additive with anti-stress and productivity-improving functions, which is mainly used for improving the feed intake of livestock and poultry and promoting the growth of broiler chickens, live pigs and the like and is added in the production process of the broiler chickens, the live pigs and the like.
Background
With the development of the large-scale livestock and poultry breeding technology, livestock and poultry live in an environment with relatively stable temperature and humidity, stress is easily caused by external stimulation, the livestock and poultry grow slowly, even diseases occur, and the breeding benefit is influenced.
In the breeding process, the factors mainly causing stress such as broilers, laying hens, live pigs and the like are as follows: (1) physiological stress. Changing materials, immunizing, laying eggs, gestation and the like; (2) environmental stress, and the living environment of livestock and poultry including temperature, illumination, gas, noise and the like. (3) Managerial stress, stress caused by feeding management errors, such as poor ventilation caused by power failure and the like, insufficient drinking water for livestock and poultry caused by water line blockage, large temperature change caused by heat preservation measures which do not meet requirements, and the like are the most common stress in chicken raising production and the stress with the greatest influence.
After the stimulation, the feed intake is usually greatly reduced, the laying rate is reduced, the growth is slow, the production performance of the livestock is reduced, the resistance is reduced, if pathogenic microorganisms exist in the environment, diseases can occur, and death and elimination are increased.
Disclosure of Invention
The invention aims to solve the technical problem of providing a traditional Chinese veterinary medicine feed additive with stress resistance and production performance improvement and a preparation method thereof. The invention has simple preparation process and convenient use, and is suitable for being added into feed.
In order to solve the technical problems, the technical scheme of the invention is as follows: the raw materials of the traditional Chinese veterinary medicine feed additive with the anti-stress and the productivity improving functions comprise the following traditional Chinese medicine materials in parts by weight: 5-10 parts of campanumoea, 5-10 parts of Chinese yam, 3-8 parts of red yeast rice, 1-5 parts of galangal, 10-30 parts of epimedium, 5-15 parts of poria cocos and 5-15 parts of liquorice.
The traditional Chinese veterinary medicine feed additive is prepared from the following raw materials in parts by weight: 5 parts of campanumoea root, 5 parts of yam, 3 parts of red yeast rice, 1 part of galangal, 10 parts of epimedium herb, 5 parts of tuckahoe and 5 parts of liquorice.
The traditional Chinese veterinary medicine feed additive is prepared from the following raw materials in parts by weight: 10 parts of campanumoea root, 10 parts of yam, 8 parts of red yeast rice, 5 parts of galangal, 30 parts of epimedium herb, 15 parts of tuckahoe and 15 parts of liquorice.
The traditional Chinese veterinary medicine feed additive is prepared from the following raw materials in parts by weight: 8 parts of campanumoea root, 7 parts of yam, 5 parts of red yeast rice, 3 parts of galangal, 20 parts of epimedium herb, 10 parts of tuckahoe and 10 parts of liquorice.
In order to better realize the aim of the invention, the invention also provides a preparation method of the veterinary traditional Chinese medicine feed additive with anti-stress and improved production performance, and the preparation method comprises the following steps.
(1) The traditional Chinese medicine crushing and mixing step: pulverizing radix Campanumoeae, rhizoma Dioscoreae, rhizoma Alpiniae Officinarum, herba Epimedii, Poria, and Glycyrrhrizae radix at a weight ratio to below 40 mesh, mixing, and sterilizing for 20min to obtain Chinese medicinal mixture; pulverizing red yeast to below 40 mesh, and mixing with the Chinese medicinal mixture to obtain mixture for fermentation.
(2) Traditional Chinese medicine fermentation: and (3) crushing and mixing the traditional Chinese medicines to obtain a mixture for fermentation, fermenting under a certain condition, inoculating a mixed strain, and fermenting to obtain the traditional Chinese veterinary medicine feed additive with anti-stress and improved production performance.
Wherein, the fermentation step of the traditional Chinese medicine is preferably as follows: adding ammonium sulfate and a fermentation strain I into a mixture for fermentation obtained in the step of crushing the traditional Chinese medicines, wherein the adding amount of the ammonium sulfate is 0.1-1% of the amount of the mixture of the traditional Chinese medicines, the amount of the inoculated mixed strain I is 1-10% of the amount of the mixture of the traditional Chinese medicines, adding a proper amount of water until the water content of the mixture is more than 40%, placing the mixture in a closed space at the temperature of 15-40 ℃, and fermenting for 36-72 hours; and after the fermentation is finished, spraying mixed strains II with the amount of 1-10% of the fermentation mixture on the surface of the fermentation product, and continuing fermenting for more than 36 hours to obtain the veterinary traditional Chinese medicine feed additive.
Wherein, in the step of fermenting the traditional Chinese medicine, the mixed strain I is as follows: aspergillus niger 108～1010cfu/mL, Trichoderma reesei 108～1010cfu/mL; the mixed strain II comprises: yeast 109～1011cfu/mL, Bacillus subtilis 109～1011cfu/mL。
The invention adopts the formula principle of invigorating spleen and stomach, warming yang and relieving exterior syndrome, adjusts the functions of spleen and stomach, relieves exterior syndrome and stagnation, solves qi stagnation caused by stress and promotes ingestion.
The campanumoea root of the invention is the root of four-leaf ginseng of campanumaea of platycodiaceae, and can strengthen spleen and stomach and tonify lung qi; the rhizoma Alpiniae Officinarum is dried rhizome of Alpinia Officinarum of Zingiberaceae, and has stomach warming and cold dispelling effects; the radix codonopsis pilosulae and the galangal are used as monarch drugs, the spleen is strengthened, the yang is warmed, the Chinese yam has the effects of tonifying the spleen and the stomach, promoting the production of body fluid and benefiting the lung, the poria cocos can strengthen the spleen and the stomach, the radix codonopsis pilosulae and the epimedium can strengthen the spleen and the kidney yang, and the yang warming effect of the galangal is strengthened.
The technical scheme provided by the embodiment of the invention has the following beneficial effects: 1) the traditional Chinese veterinary medicine feed additive prepared by fermenting the traditional Chinese medicines can improve the feed intake of livestock and poultry, reduce the adverse reaction caused by stress and promote growth. 2) After fermentation, the Chinese veterinary medicine feed additive contains bacillus with the number of 108More than cfu/g, which helps to condition the intestinal function.
Drawings
Fig. 1 is a graph showing the variation of feed intake in each group in the effect of application 3.
Detailed Description
Example 1
The traditional Chinese medicine raw materials of the traditional Chinese veterinary medicine feed additive comprise: 10kg of campanumoea root, 10kg of yam, 8kg of red yeast rice, 5kg of galangal, 30kg of epimedium herb, 15kg of tuckahoe and 15kg of liquorice.
The preparation method of the veterinary feed additive in this example is as follows.
(1) The traditional Chinese medicine crushing and mixing step: pulverizing radix Campanumoeae 10kg, rhizoma Dioscoreae 10kg, rhizoma Alpiniae Officinarum 5kg, herba Epimedii 30kg, Poria 15kg, and Glycyrrhrizae radix 15kg to 80 mesh, mixing, and sterilizing for 30min to obtain Chinese medicinal mixture; pulverizing 8kg of red yeast rice to 80 mesh, and mixing with the Chinese medicinal mixture to obtain mixture for fermentation.
(2) And (3) microbial fermentation: and (3) crushing and mixing the traditional Chinese medicines to obtain a mixture for fermentation, fermenting under a certain condition, inoculating a mixed strain, and fermenting to obtain the traditional Chinese veterinary medicine feed additive with anti-stress and improved production performance.
The fermentation steps of the traditional Chinese medicine are preferably as follows: adding ammonium sulfate and mixed strain I into the mixture for fermentation obtained in the crushing step, wherein the adding amount of the ammonium sulfate is 0.1% of the amount of the traditional Chinese medicine mixture, the amount of the inoculated mixed strain I is 1% of the amount of the traditional Chinese medicine mixture, adding a proper amount of water until the water content of the mixture is 40%, placing the mixture in a closed space at the temperature of 15 ℃, and fermenting for 36 hours; after the fermentation is finished, spraying mixed strains II with the amount of 1% of the fermentation mixture on the surface of the fermentation product, and continuing the fermentation for 36h to obtain the traditional Chinese veterinary medicine feed additive.
(3) In the step of fermenting the traditional Chinese medicine, the mixed strain I is as follows: aspergillus niger 108cfu/mL, Trichoderma reesei 108cfu/mL; the mixed strain II comprises: yeast 109cfu/mL, Bacillus subtilis 109cfu/mL。
The technical effects are as follows:
the veterinary drug feed additive prepared in example 1 was subjected to bacillus counting by plate counting method, and the result was 2.7 × 109cfu/g。
In the embodiment, the crushing to 40 meshes is adopted, and the sterilization is performed for 20min to ensure the uniform mixing, facilitate the fermentation operation and reduce the fermentation time; of course, through the description of the present embodiment, the following method can be obtained by the ordinary engineers in the art without creative work: the method of pulverizing the Chinese traditional medicine to 20 meshes and sterilizing for 5min is also within the protection scope of the invention.
In the fermentation process of the embodiment, factors such as the inoculation amount and the fermentation time are adopted, so that the full fermentation is ensured as much as possible; of course, through the description of the present embodiment, those skilled in the art can derive the following methods without creative efforts: the fermentation inoculation amount is reduced to be within 1 percent, the fermentation time is less than 36 hours, and the places are also within the protection scope of the invention.
Example 2
The traditional Chinese medicine raw materials of the traditional Chinese veterinary medicine feed additive comprise: 10kg of campanumoea root, 5kg of yam, 3kg of red yeast rice, 1kg of galangal, 10kg of epimedium herb, 5kg of tuckahoe and 5kg of liquorice.
The preparation method of the veterinary feed additive in this example is as follows.
(1) The traditional Chinese medicine crushing and mixing step: pulverizing radix Campanumoeae 5kg, rhizoma Dioscoreae 5kg, rhizoma Alpiniae Officinarum 1kg, herba Epimedii 10kg, Poria 5kg, and Glycyrrhrizae radix 5kg to 40 mesh, mixing, and sterilizing for 20min to obtain Chinese medicinal mixture; pulverizing 3kg of red rice to below 40 mesh, and mixing with the Chinese medicinal mixture to obtain mixture for fermentation.
(2) And (3) microbial fermentation: and (3) crushing and mixing the traditional Chinese medicines to obtain a mixture for fermentation, fermenting under a certain condition, inoculating a mixed strain, and fermenting to obtain the traditional Chinese veterinary medicine feed additive with anti-stress and improved production performance.
The fermentation steps of the traditional Chinese medicine are preferably as follows: adding ammonium sulfate and mixed strain I into the mixture obtained in the crushing step, wherein the adding amount of the ammonium sulfate is 0.1 percent of the amount of the traditional Chinese medicine mixture, the amount of the inoculated mixed strain I is 10 percent of the amount of the traditional Chinese medicine mixture, adding a proper amount of water until the water content of the mixture is 80 percent, placing the mixture in a closed space at the temperature of 40 ℃, and fermenting for 72 hours; after the fermentation is finished, spraying mixed strains II with the amount of 10% of the fermentation mixture on the surface of the fermentation product, and continuing to ferment for 72h to obtain the traditional Chinese veterinary medicine feed additive.
(3) In the step of fermenting the traditional Chinese medicine, the mixed strain I is as follows: aspergillus niger 1010cfu/mL, Trichoderma reesei 1010cfu/mL; the mixed strain II comprises: yeast 1011cfu/mL, Bacillus subtilis 1011cfu/mL。
The technical effects are as follows:
the Chinese veterinary drug feed additive prepared in example 1 was subjected to bacillus counting by plate counting method, and the result was 2.1 × 109Per gram.
In the embodiment, the crushing to 80 meshes is adopted, and the sterilization is carried out for 30min to ensure the uniform mixing, facilitate the fermentation operation and reduce the fermentation time; of course, through the description of the present embodiment, the following method can be obtained by the ordinary engineers in the art without creative work: the traditional Chinese medicine is crushed into 120 meshes and sterilized for 60min, and the methods also fall within the protection scope of the invention.
In the fermentation process of the embodiment, factors such as the inoculation amount and the fermentation time are adopted, so that the full fermentation is ensured as much as possible; of course, through the description of the present embodiment, those skilled in the art can derive the following methods without creative efforts: the fermentation inoculation amount is increased to more than 10%, the fermentation time is more than 72h, and the places are also within the protection scope of the invention.
Example 3
The traditional Chinese medicine raw materials of the traditional Chinese veterinary medicine feed additive comprise: 8kg of campanumoea root, 7kg of yam, 5kg of red yeast rice, 3kg of galangal, 20kg of epimedium herb, 10kg of tuckahoe and 12kg of liquorice.
The preparation method of the veterinary feed additive in this example is as follows.
(1) The traditional Chinese medicine crushing and mixing step: pulverizing 8kg of radix Campanumoeae, 7kg of rhizoma Dioscoreae, 3kg of rhizoma Alpiniae Officinarum, 20kg of herba Epimedii, 10kg of Poria and 12kg of Glycyrrhrizae radix to 60 mesh, mixing, and sterilizing for 30min to obtain Chinese medicinal mixture; pulverizing 5kg of red rice to 60 mesh, and mixing with the Chinese medicinal mixture to obtain mixture for fermentation.
(2) And (3) microbial fermentation: and (3) crushing and mixing the traditional Chinese medicines to obtain a mixture for fermentation, fermenting under a certain condition, inoculating a mixed strain II, and fermenting to obtain the traditional Chinese veterinary medicine feed additive with anti-stress and improved production performance.
The fermentation steps of the traditional Chinese medicine are preferably as follows: adding ammonium sulfate and mixed strain I into the mixture for fermentation obtained in the crushing step, wherein the adding amount of the ammonium sulfate is 0.5 percent of the amount of the traditional Chinese medicine mixture, the amount of the inoculated mixed strain I is 5 percent of the amount of the traditional Chinese medicine mixture, adding a proper amount of water until the water content of the mixture is 60 percent, placing the mixture in a closed space at the temperature of 30 ℃, and fermenting for 54 hours; after the fermentation is finished, spraying mixed strains II with the amount of 5% of the fermentation mixture on the surface of the fermentation product, and continuing to ferment for 50h to obtain the traditional Chinese veterinary medicine feed additive.
(3) In the step of fermenting the traditional Chinese medicine, the mixed strain I is as follows: aspergillus niger 109cfu/mL, Trichoderma reesei 108cfu/mL; the mixed strain II comprises: yeast 1010cfu/mL, Bacillus subtilis 109cfu/mL。
The technical effects are as follows:
the Chinese veterinary drug feed additive prepared in example 3 was subjected to bacillus counting by plate counting method, and the result was 4.2 × 109cfu/g。
The application effect is as follows:
1. in 2015, a broiler breeding company in Shandong province and a farm have 8 broiler breeding houses, the breeding amount of each broiler breeding house is 18000, 2 broiler breeding houses use the traditional Chinese veterinary medicine feed additive in example 1 at the age of 32 days, the feed is continuously used for 4 days according to 0.1% of the feed intake, and 2 broiler breeding houses use the mixture of the traditional Chinese medicine raw materials and red yeast rice in example 1 without fermentation and are continuously used for 4 days according to 0.1% of the feed intake. The weight of the feed additive is weighed in the slaughter at 39 days, the mortality is counted, and the feed-meat ratio is calculated, so that the average weight of the feed additive in the henhouse using the traditional Chinese veterinary medicine feed additive prepared in example 1 is 2954g, the death rate after 32 days is 0.64%, the feed-meat ratio is 1.69, the average weight of the feed additive in the henhouse using the traditional Chinese medicine raw materials is 2878g, the mortality rate after 32 days is 1.04%, and the feed-meat ratio is 1.71. According to the results, the traditional Chinese veterinary medicine feed additive can improve the slaughter average body weight, reduce the death rate, improve the feed utilization rate and promote the growth of the broilers in 4 henhouses using other medicines, wherein the slaughter average body weight of the chickens at 39 days is 2804g, the death rate after 32 days is 1.59%, and the feed-meat ratio is 1.76.
2. In 6 months 2015, in a certain pig farm in the Weifang city, newly weaned piglets are diarrhea, the feed intake is gradually reduced, the death rate is gradually increased, 80 weaned piglets in the Weifang city are randomly selected and are respectively divided into 3 groups, wherein 2 groups of the piglets respectively use the traditional Chinese veterinary medicine feed additive prepared in the embodiment 2 and the embodiment 3, 1 group of the piglets does not use medicines as a control group, the piglets are mixed with the feed according to the amount of 10g of each piglet and are continuously used for 5 days, after 3 days of application, the diarrhea symptom of the piglets is relieved, the death rate is reduced, compared with the piglets which are not used, the feed intake of each piglet is increased by more than 6g, the death rate is reduced by 50%, after 1 week, the piglets using the pigs in the embodiment 2 and the embodiment 3 are recovered, the feed intake is gradually increased, and the feed intake of the control group is not recovered, and the pig farm starts to add the traditional Chinese veterinary medicine feed additive prepared in the embodiment 2 into the control group.
3. In order to accurately count the feeding promoting effect of the traditional Chinese veterinary medicine feed additive, 400 healthy 21-day-old broilers are divided into 4 groups, each group is repeated for 4 times, the traditional Chinese veterinary medicine feed additives of the embodiment 1, the embodiment 2 and the embodiment 3 are respectively used in three groups, the feed is mixed according to the feed intake of 0.1% for 5 days, the average feed intake change of each group at 21-35 days is respectively counted, and the weight at 35 days is counted. The feed intake curve changes as shown in the figure, the average feed intake of the broilers in the using example is 10g higher than that of the control group, the weight of 35 days old is 215 g/body more in the example 3 group, 178 g/body more in the example 2 group and 172 g/body more in the example 1 group than that of the control group.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (5)
1. The traditional Chinese veterinary medicine feed additive is characterized by comprising the following raw materials in parts by weight: 5-10 parts of campanumoea, 5-10 parts of Chinese yam, 3-8 parts of red yeast rice, 1-5 parts of galangal, 10-30 parts of epimedium, 5-15 parts of poria cocos and 5-15 parts of liquorice; the preparation method of the traditional Chinese veterinary medicine feed additive comprises the following steps: (1) the traditional Chinese medicine crushing and mixing step: pulverizing radix Campanumoeae, rhizoma Dioscoreae, rhizoma Alpiniae Officinarum, herba Epimedii, Poria, and Glycyrrhrizae radix at a weight ratio to below 40 mesh, mixing, and sterilizing for 20min to obtain Chinese medicinal mixture; pulverizing red yeast to below 40 mesh, and mixing with the Chinese medicinal mixture to obtain mixture for fermentation; (2) and (3) microbial fermentation: adding ammonium sulfate and a mixed strain I into the mixture for fermentation obtained in the step of crushing and mixing the traditional Chinese medicines, wherein the adding amount of the ammonium sulfate is 0.1-1% of the amount of the mixture for the traditional Chinese medicines, the inoculation amount of the mixed strain I is 1-10% of the amount of the mixture for the traditional Chinese medicines, then adding a proper amount of water until the water content of the mixture for fermentation is more than 40%, placing the mixture for fermentation in a closed space at the temperature of 15-40 ℃, and fermenting for 36-72 hours; and after the fermentation is finished, spraying mixed strains II with the amount of 1-10% of the fermentation mixture on the surface of the fermentation product, and continuing fermenting for more than 36 hours to obtain the veterinary traditional Chinese medicine feed additive.
2. The anti-stress traditional Chinese veterinary medicine feed additive for improving the production performance according to claim 1, which is characterized in that the raw materials of the traditional Chinese veterinary medicine feed additive comprise the following traditional Chinese medicinal materials in parts by weight: 5 parts of campanumoea root, 5 parts of yam, 3 parts of red yeast rice, 1 part of galangal, 10 parts of epimedium herb, 5 parts of tuckahoe and 5 parts of liquorice.
3. The anti-stress traditional Chinese veterinary medicine feed additive for improving the production performance according to claim 1, which is characterized in that the raw materials of the traditional Chinese veterinary medicine feed additive comprise the following traditional Chinese medicinal materials in parts by weight: 10 parts of campanumoea root, 10 parts of yam, 8 parts of red yeast rice, 5 parts of galangal, 30 parts of epimedium herb, 15 parts of tuckahoe and 15 parts of liquorice.
4. The anti-stress traditional Chinese veterinary medicine feed additive for improving the production performance according to claim 1, which is characterized in that the raw materials of the traditional Chinese veterinary medicine feed additive comprise the following traditional Chinese medicinal materials in parts by weight: 8 parts of campanumoea root, 7 parts of yam, 5 parts of red yeast rice, 3 parts of galangal, 20 parts of epimedium herb, 10 parts of tuckahoe and 10 parts of liquorice.
5. The anti-stress and productivity-enhancing veterinary herbal feed additive according to any one of claims 1-4, wherein in the step of microbial fermentation, the mixed strain I is: aspergillus niger 108～1010cfu/mL, Trichoderma reesei 108～1010cfu/mL; the mixed strain II comprises: yeast 109～1011cfu/mL, Bacillus subtilis 109～1011cfu/mL。
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| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN103211112A (en) * | 2013-03-27 | 2013-07-24 | 广州绿州生物技术有限公司 | Chinese herbal medicine growth promotion feed additive for fowl and preparation method of feed additive |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN103211112A (en) * | 2013-03-27 | 2013-07-24 | 广州绿州生物技术有限公司 | Chinese herbal medicine growth promotion feed additive for fowl and preparation method of feed additive |
Non-Patent Citations (4)
| Title |
|---|
| "健鸡散"对肉鸡新城疫免疫效果的影响;张波等;《吉林畜牧兽医》;20110701;第32卷(第07期);第21-22页 * |
| 四种调补方对反复心理应激大鼠下丘脑及海马氨基酸含量影响的比较;张正等;《安徽中医学院学报》;20030831;第22卷(第04期);第32-35页 * |
| 家畜应激综合症的辨证论治;杨恒怀;《中兽医医药杂志》;20011231(第01期);第23-25页 * |
| 调肝、补肾、健脾方药对慢性心理应激大鼠单胺类神经递质影响的比较研究;严灿等;《中国中西医结合杂志》;20021220;第22卷(第12期);第925-928页 * |
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