CN106177705A - Anti-stress, the herbal medicine feed additive improving production performance and preparation method thereof - Google Patents
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses anti-stress, improve herbal medicine feed additive and preparation method thereof of production performance, herbal medicine feed additive includes the raw medicinal material of following ratio of weight and number: Radix Campanumoeae 5 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, 5 ~ 10 parts of Monas cuspurpureus Went, Rhizoma Alpiniae Officinarum 1 ~ 5 part, Herba Epimedii 10 ~ 30 parts, Poria 5~15 parts and 5 ~ 15 parts of Radix Glycyrrhizae;Its preparation technology includes: Chinese medicine is pulverized and mixed, microbial fermentation step.The herbal medicine feed additive using the present invention can reduce the stress of poultry, promotes to search for food, and improves efficiency of feed utilization, improves livestock and poultry production performance.
Description
Technical field
The present invention relates to the herbal medicine feed additive of poultry, particularly to anti-stress, improve in production performance
Veterinary drug feed additive, is mainly used in improving the feed intake of poultry, promotes the growth of broiler, live pig etc., broiler, live pig etc.
Production process is added.
Background technology
Along with the development of poultry large-scale cultivation technology, poultry live in temperature, the metastable environment of humidity, extraneous
Stimulate easily cause stress, cause growth of animals or poultry slow, disease even occur, affects culture benefit.
In breeding process, broiler, laying hen, live pig etc. mainly cause stress because have: (1) physiological stress.Reload,
Immunity, lay eggs, gestation etc.;(2) Environmental stress, the living environment of poultry includes temperature, illumination, gas, noise etc. significantly
Change.(3) managerial stress, due to feeding and management error and cause stress, the improper ventilation such as caused due to power-off etc.,
Waterline blocking causes poultry not have enough drinking-water, and Insulation is not reaching to requirement and causes temperature significantly change etc., is poultry
In production modal, also be impact maximum stress.
Above-mentioned stress occur after, often show as declining to a great extent of feed intake, then occur laying rate decline, poor growth,
Thus causing livestock and poultry production performance to decline, resistance declines, and as environment exists pathogenic microorganism, then disease can occur, and dead washing in a pan increases
Add.
Summary of the invention
The technical problem to be solved be to provide anti-stress, improve production performance herbal medicine feed additive and
Its preparation method.Preparation technology of the present invention is simple, easy to use, is suitable in feedstuff adding using.
In order to solve above-mentioned technical problem, the technical scheme is that anti-stress, the herbal medicine of raising production performance are raised
The raw material of feed additives, including following ratio of weight and number Chinese medicinal material: Radix Campanumoeae 5~10 parts, Rhizoma Dioscoreae 5~10 parts, Monas cuspurpureus Went 3~8
Part, Rhizoma Alpiniae Officinarum 1~5 parts, Herba Epimedii 10~30 parts, Poria 5~15 parts and Radix Glycyrrhizae 5~15 parts.
Each raw materials of traditional Chinese medicinal materials of described herbal medicine feed additive and ratio of weight and number thereof are preferably: Radix Campanumoeae 5 parts, Rhizoma Dioscoreae
5 parts, 3 parts of Monas cuspurpureus Went, Rhizoma Alpiniae Officinarum 1 part, Herba Epimedii 10 parts, 5 parts of Poria and 5 parts of Radix Glycyrrhizae.
Each raw materials of traditional Chinese medicinal materials of described herbal medicine feed additive and ratio of weight and number thereof are preferably: Radix Campanumoeae 10 parts, mountain
Medicine 10 parts, 8 parts of Monas cuspurpureus Went, Rhizoma Alpiniae Officinarum 5 parts, Herba Epimedii 30 parts, 15 parts of Poria and 15 parts of Radix Glycyrrhizae.
Each raw materials of traditional Chinese medicinal materials of described herbal medicine feed additive and ratio of weight and number thereof are preferably: Radix Campanumoeae 8 parts, Rhizoma Dioscoreae
7 parts, 5 parts of Monas cuspurpureus Went, Rhizoma Alpiniae Officinarum 3 parts, Herba Epimedii 20 parts, 10 parts of Poria and 10 parts of Radix Glycyrrhizae.
In order to preferably realize foregoing invention purpose, present invention also offers anti-stress, the herbal medicine of raising production performance
The preparation method of feed additive, preparation method comprises the following steps.
(1) blend step pulverized by Chinese medicine: by Radix Campanumoeae, Rhizoma Dioscoreae, Rhizoma Alpiniae Officinarum, Herba Epimedii, Poria, Radix Glycyrrhizae powder by weight ratio
It is broken to below 40 mesh, mixes sterilizing 20min, obtain Traditional Chinese drug mixture;Hongqu powder (red colouring agent) is broken to below 40 mesh, mixes with Traditional Chinese drug mixture
Even, obtain fermentation mixture.
(2) herb fermenting step: described Chinese medicine is pulverized the fermentation mixture obtained in blend step, at certain condition
After bottom fermentation, inoculate fermented by mixed bacterium, obtain anti-stress, the herbal medicine feed additive of raising production performance.
Wherein, described herb fermenting is preferably a step: the fermentation mixture obtained by Chinese medicine pulverising step, adds sulphuric acid
Ammonium and fermented bacterium I, ammonium sulfate addition is the 0.1%~1% of Traditional Chinese drug mixture amount, and the amount of inoculation mixed bacteria I is that Chinese medicine mixes
The 1%~10% of compound, adds appropriate water, and to mixture water content more than 40%, being positioned over temperature is 15~40 DEG C close
Close space, fermentation 36~72h;After fermentation ends, send fermenting mixture amount 1~the mixed bacteria II of 10% forth on fermented product surface,
Continue fermentation more than 36h, i.e. obtain herbal medicine feed additive.
Wherein, in described herb fermenting step, mixed bacteria I is: aspergillus niger 108~1010Cfu/mL, trichoderma reesei 108
~1010cfu/mL;Mixed bacteria II is: yeast 109~1011Cfu/mL, bacillus subtilis 109~1011cfu/mL。
The present invention uses that strong The spleen is closely related to the stomach, the principles of formulating prescriptions of warming YANG for relieving the exterior syndrome, adjusts spleen and stomach function, and relieving the exterior syndromeization is stagnant, solve due to
The stagnation of QI that stress cause, promotes to search for food.
In the present invention, Radix Campanumoeae is the root of campanulaceae Codonopsis plant Radix Codonopsis Lanceolatae, energy strengthening the spleen and stomach, tonifying the lung gas;Rhizoma Alpiniae Officinarum is Rhizoma Zingiberis Recens
Section's plant Rhizoma Alpiniae Officinarum dry rhizome, has the effect of warming stomach for dispelling cold;Radix Campanumoeae, Rhizoma Alpiniae Officinarum have as monarch drug, spleen invigorating warming YANG, Rhizoma Dioscoreae
Having spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, Poria energy invigorating the spleen and regulating the stomach, the two helps Radix Campanumoeae spleen invigorating, Herba Epimedii kidney-replenishing altogether, strengthens
The warming YANG effect of Rhizoma Alpiniae Officinarum, Monas cuspurpureus Went is the Monas cuspurpureus Went that Aspergillaceae fungus monascus parpureus Went colonizes on Semen oryzae sativae, have spleen invigorating,
The function that relieving the exterior syndromeization is stagnant, with above-mentioned Chinese medicine mixed fermentation, it is possible to increase medicine spleen-invigorating function, reduces bad smell.
The embodiment of the present invention provide technical scheme have the benefit that 1), above-mentioned Chinese medicine by fermentation prepare
Herbal medicine feed additive, it is possible to increase poultry feed intake, reduces the untoward reaction that stress cause, and promotes growth.2) through sending out
After ferment, in herbal medicine feed additive, the quantity containing bacillus cereus is 108More than cfu/g, assists conditioning function of intestinal canal.
Accompanying drawing explanation
Fig. 1 is each group feed intake change curve in application effect 3.
Detailed description of the invention
Embodiment 1
Consisting of of each raw material raw material of Chinese medicine of the described herbal medicine feed additive of the present embodiment: Radix Campanumoeae 10kg, Rhizoma Dioscoreae
10kg, Monas cuspurpureus Went 8kg, Rhizoma Alpiniae Officinarum 5kg, Herba Epimedii 30kg, Poria 15kg and Radix Glycyrrhizae 15kg.
The preparation method of the present embodiment herbal medicine feed additive is as follows.
(1) blend step pulverized by Chinese medicine: by Radix Campanumoeae 10kg, Rhizoma Dioscoreae 10kg, Rhizoma Alpiniae Officinarum 5kg, Herba Epimedii 30kg, Poria
15kg, Radix Glycyrrhizae 15kg are crushed to 80 mesh, mix sterilizing 30min, obtain Traditional Chinese drug mixture;Monas cuspurpureus Went 8kg is crushed to 80 mesh, with Chinese medicine
Mixture mixes, and obtains fermentation mixture,.
(2) microbial fermentation step: described Chinese medicine is pulverized the fermentation mixture obtained in blend step, at certain bar
After part bottom fermentation, inoculate fermented by mixed bacterium, obtain anti-stress, the herbal medicine feed additive of raising production performance.
Herb fermenting is preferably a step: the fermentation mixture obtained by pulverising step, adds ammonium sulfate and mixed bacteria
I, ammonium sulfate addition is the 0.1% of Traditional Chinese drug mixture amount, amount is Traditional Chinese drug mixture the 1% of inoculation mixed bacteria I, adds suitable
The water of amount, to mixture water content 40%, is positioned over the confined space that temperature is 15 DEG C, and ferment 36h;After fermentation ends, sending out
The mixed bacteria II of fermenting mixture amount 1% is sent on ferment thing surface forth, continues fermentation 36h, i.e. obtains herbal medicine feed additive.
(3), in described herb fermenting step, mixed bacteria I is: aspergillus niger 108Cfu/mL, trichoderma reesei 108cfu/mL;Mixed
Closing strain II is: yeast 109Cfu/mL, bacillus subtilis 109cfu/mL。
Technique effect:
The herbal medicine feed additive using colony counting method to prepare embodiment 1 carries out bacillus cereus counting, and result is 2.7 ×
109cfu/g。
Wherein, the present embodiment uses and is crushed to 40 mesh, and sterilizing 20min is to ensure that mix homogeneously and is easy to fermentation behaviour
Make, reduce fermentation time;Certainly, by the explanation of the present embodiment, in this area, ordinary skill technical staff is without creativeness
Work also can draw following method: Chinese medicine powder is broken to 20 mesh, sterilizing 5min, and these methods also should be in protection scope of the present invention
Within.
The inoculum concentration of the employing in the present embodiment sweat, the factor such as fermentation time, ensure filling of fermentation as far as possible
Divide and carry out;Certainly, by the explanation of the present embodiment, one of ordinary skilled in the art also can draw without creative work
Following method: within fermentation inoculum concentration is reduced to 1%, fermentation time is less than 36h, and these places also should be in the protection of the present invention
Within the scope of.
Embodiment 2
Consisting of of each raw material raw material of Chinese medicine of the described herbal medicine feed additive of the present embodiment: Radix Campanumoeae 10kg, Rhizoma Dioscoreae
5kg, Monas cuspurpureus Went 3kg, Rhizoma Alpiniae Officinarum 1kg, Herba Epimedii 10kg, Poria 5kg and Radix Glycyrrhizae 5kg.
The preparation method of the present embodiment herbal medicine feed additive is as follows.
(1) Chinese medicine pulverize blend step: by Radix Campanumoeae 5kg, Rhizoma Dioscoreae 5kg, Rhizoma Alpiniae Officinarum 1kg, Herba Epimedii 10kg, Poria 5kg,
Radix Glycyrrhizae 5kg is crushed to 40 mesh, mixes sterilizing 20min, obtains Traditional Chinese drug mixture;Monas cuspurpureus Went 3kg is crushed to below 40 mesh, mixes with Chinese medicine
Compound mixes, and obtains fermentation mixture,.
(2) microbial fermentation step: described Chinese medicine is pulverized the fermentation mixture obtained in blend step, at certain bar
After part bottom fermentation, inoculate mixed bacteria, fermentation, obtain anti-stress, the herbal medicine feed additive of raising production performance.
Herb fermenting is preferably a step: the fermentation mixture obtained by pulverising step, adds ammonium sulfate and mixed bacteria
I, ammonium sulfate addition is the 0.1% of Traditional Chinese drug mixture amount, amount is Traditional Chinese drug mixture the 10% of inoculation mixed bacteria I, adds
Appropriate water, to mixture water content 80%, is positioned over the confined space that temperature is 40 DEG C, and ferment 72h;After fermentation ends,
The mixed bacteria II of fermenting mixture amount 10% is sent on fermented product surface forth, continues fermentation 72h, i.e. obtains herbal medicine feed additive.
(3), in described herb fermenting step, mixed bacteria I is: aspergillus niger 1010Cfu/mL, trichoderma reesei 1010cfu/mL;
Mixed bacteria II is: yeast 1011Cfu/mL, bacillus subtilis 1011cfu/mL。
Technique effect:
The herbal medicine feed additive using colony counting method to prepare embodiment 1 carries out bacillus cereus counting, and result is 2.1 ×
109Individual/g.
Wherein, the present embodiment uses and is crushed to 80 mesh, and sterilizing 30min is to ensure that mix homogeneously and is easy to fermentation behaviour
Make, reduce fermentation time;Certainly, by the explanation of the present embodiment, in this area, ordinary skill technical staff is without creativeness
Work also can draw following method: Chinese medicine powder is broken to 120 mesh, sterilizing 60min, and these methods also should be at the protection model of the present invention
Within enclosing.
The inoculum concentration of the employing in the present embodiment sweat, the factor such as fermentation time, ensure filling of fermentation as far as possible
Divide and carry out;Certainly, by the explanation of the present embodiment, one of ordinary skilled in the art also can draw without creative work
Following method: fermentation inoculum concentration is increased to more than 10%, fermentation time is more than 72h, and these places also should be in the protection of the present invention
Within the scope of.
Embodiment 3
Consisting of of each raw material raw material of Chinese medicine of the described herbal medicine feed additive of the present embodiment: Radix Campanumoeae 8kg, Rhizoma Dioscoreae 7kg,
Monas cuspurpureus Went 5kg, Rhizoma Alpiniae Officinarum 3kg, Herba Epimedii 20kg, Poria 10kg and Radix Glycyrrhizae 12kg.
The preparation method of the present embodiment herbal medicine feed additive is as follows.
(1) blend step pulverized by Chinese medicine: by Radix Campanumoeae 8kg, Rhizoma Dioscoreae 7kg, Rhizoma Alpiniae Officinarum 3kg, Herba Epimedii 20kg, Poria
10kg, Radix Glycyrrhizae 12kg are crushed to 60 mesh, mix sterilizing 30min, obtain Traditional Chinese drug mixture;Monas cuspurpureus Went 5kg is crushed to 60 mesh, with Chinese medicine
Mixture mixes, and obtains fermentation mixture,.
(2) microbial fermentation step: described Chinese medicine is pulverized the fermentation mixture obtained in blend step, at certain bar
After part bottom fermentation, inoculate mixed bacteria II, fermentation, obtain anti-stress, the herbal medicine feed additive of raising production performance.
Herb fermenting is preferably a step: the fermentation mixture obtained by pulverising step, adds ammonium sulfate and mixed bacteria
I, ammonium sulfate addition is the 0.5% of Traditional Chinese drug mixture amount, amount is Traditional Chinese drug mixture the 5% of inoculation mixed bacteria I, adds suitable
The water of amount, to mixture water content 60%, is positioned over the confined space that temperature is 30 DEG C, and ferment 54h;After fermentation ends, sending out
The mixed bacteria II of fermenting mixture amount 5% is sent on ferment thing surface forth, continues fermentation 50h, i.e. obtains herbal medicine feed additive.
(3), in described herb fermenting step, mixed bacteria I is: aspergillus niger 109Cfu/mL, trichoderma reesei 108cfu/mL;Mixed
Closing strain II is: yeast 1010Cfu/mL, bacillus subtilis 109cfu/mL。
Technique effect:
The herbal medicine feed additive using colony counting method to prepare embodiment 3 carries out bacillus cereus counting, and result is 4.2 ×
109cfu/g。
Application effect:
1,2015, broiler breeding company of Shandong Province, plant had 8 feeding of broiler houses, and every cultivation amount is 18000
Only, 2 therein, begin to use the herbal medicine feed additive of embodiment 1 at 32 ages in days, according to feed intake 0.1% at feedstuff
In use 4 days continuously, other 2 raw material of Chinese medicine only used in unleavened embodiment 1 and the mixture of Monas cuspurpureus Went, according to adopting
The 0.1% of appetite uses 4 days in feedstuff continuously.Deliver for sale at 39 ages in days and weigh, add up mortality rate, calculate feedstuff-meat ratio and find, use
Average weight delivered for sale by the hen house of the herbal medicine feed additive that embodiment 1 prepares is 2954g, and the dead pottery rate after 32 ages in days is
0.64%, feedstuff-meat ratio is 1.69, and the average weight of delivering for sale using raw material of Chinese medicine is 2878g, and after 32 ages in days, mortality rate is 1.04%, material
Meat ratio is 1.71.Using 4 hen houses of other drug, it is 2804g that 39 ages in days deliver average weight for sale, and the death rate after 32 ages in days is
1.59%, feedstuff-meat ratio is 1.76, from the above from the point of view of, herbal medicine feed additive can improve delivers average weight for sale, reduces dead pottery
Rate, improves efficiency of feed utilization, promotes the growth of broiler.
2, in June, 2015, on pig farm, Weifang City, weanling piglet is suffered from diarrhoea, and feed intake is gradually lowered, death rate
Being gradually increased, randomly choose 80 ablactational baby pig therein respectively, be respectively divided into 3 groups, wherein 2 groups use embodiment 2 He respectively
The herbal medicine feed additive that embodiment 3 prepares, 1 group does not use medicine as a control group, according to the amount spice of every piglet 10g
Using 5 days continuously, after being suitable for 3 days, find that piglet diarrhea symptom alleviates, dead quantity of washing in a pan presents downward trend, with untapped phase
Ratio, every feed intake increases more than 6g, and death rate reduces by 50%, uses the swinery of embodiment 2 and embodiment 3 to recover strong after 1 week
Health, feed intake is gradually increased, and matched group feed intake is not recovered, and pig farm starts to add the herbal medicine of embodiment 2 in matched group
Feed additive.
3, the promotion for the herbal medicine feed additive of accurate statistics the present embodiment is searched for food effect, by 400, and healthy 21
Day-old Broiler Chickens is divided into 4 groups, often 4 repetitions of group, and wherein three groups use embodiment 1, embodiment 2, the herbal medicine of embodiment 3 to raise respectively
Feed additives, the feed intake spice according to 0.1% uses 5 days, the change of the average feed intake that statistics 21~35 ages in days are often organized respectively
Change, add up body weight during 35 age in days.Feed intake curvilinear motion such as accompanying drawing, uses the average feed intake of broiler of embodiment to compare matched group
High 10g, 35 3 groups of 215g/s more than matched group of age in days body weight embodiment, 2 groups of 178g/s more than matched group of embodiment, embodiment 1
Group 172g/ more than matched group is only.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (7)
1. anti-stress, the herbal medicine feed additive of raising production performance, it is characterised in that described herbal medicine feed additive
Raw material includes the Chinese medicinal material of following ratio of weight and number: Radix Campanumoeae 5 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 10 parts, 3 ~ 8 parts of Monas cuspurpureus Went, Rhizoma Alpiniae Officinarum 1 ~ 5
Part, Herba Epimedii 10 ~ 30 parts, Poria 5~15 parts and 5 ~ 15 parts of Radix Glycyrrhizae.
Anti-stress the most according to claim 1, the herbal medicine feed additive of raising production performance, it is characterised in that institute
The ratio of weight and number stating herbal medicine feed additive needed raw material Chinese crude drug can be preferably: Radix Campanumoeae 5 parts, Rhizoma Dioscoreae 5 parts, Monas cuspurpureus Went
3 parts, Rhizoma Alpiniae Officinarum 1 part, Herba Epimedii 10 parts, 5 parts of Poria and 5 parts of Radix Glycyrrhizae.
Anti-stress the most according to claim 1, the herbal medicine feed additive of raising production performance, it is characterised in that institute
The ratio of weight and number stating herbal medicine feed additive needed raw material Chinese crude drug can be preferably: Radix Campanumoeae 10 parts, Rhizoma Dioscoreae 10 parts, red
Bent 8 parts, Rhizoma Alpiniae Officinarum 5 parts, Herba Epimedii 30 parts, 15 parts of Poria and 15 parts of Radix Glycyrrhizae.
Anti-stress the most according to claim 1, the herbal medicine feed additive of raising production performance, it is characterised in that institute
The ratio of weight and number stating herbal medicine feed additive needed raw material Chinese crude drug can be preferably: Radix Campanumoeae 8 parts, Rhizoma Dioscoreae 7 parts, Monas cuspurpureus Went
5 parts, Rhizoma Alpiniae Officinarum 3 parts, Herba Epimedii 20 parts, 10 parts of Poria and 10 parts of Radix Glycyrrhizae.
5. anti-stress as described in claim 1-4 any one, improve the preparation of the herbal medicine feed additive of production performance
Method, it is characterised in that preparation method comprises the following steps: blend step pulverized by (1) Chinese medicine: by Radix Campanumoeae, Rhizoma Dioscoreae, Gao Liang
Rhizoma Zingiberis Recens, Herba Epimedii, Poria, Radix Glycyrrhizae are crushed to below 40 mesh by weight ratio, mix sterilizing 20min, obtain Traditional Chinese drug mixture;Monas cuspurpureus Went
It is crushed to below 40 mesh, mixes with Traditional Chinese drug mixture, obtain fermentation mixture;(2) microbial fermentation step: by described Chinese medicine
It is pulverized and mixed in step and obtains fermentation mixture, under certain condition after fermentation, inoculation fermentation mixture amount 1~10% again
Mixed bacteria II, fermentation obtain anti-stress, improve production performance herbal medicine feed additive.
Anti-stress the most according to claim 5, improving the preparation method of herbal medicine feed additive of production performance, it is special
Levying and be, described microbial fermentation step is preferably: after the Traditional Chinese drug mixture obtained by pulverising step and Monas cuspurpureus Went mixing, add sulfur
Acid ammonium and mixed bacteria I, ammonium sulfate addition is the 0.1%~1% of Traditional Chinese drug mixture amount, and the amount of inoculation mixed bacteria I is Chinese medicine
The 1%~10% of mixture, adds appropriate water, and to mixture water content more than 40%, being positioned over temperature is 15~40 DEG C
Confined space, fermentation 36~72h;After fermentation ends, send fermenting mixture amount 1~the mixed bacteria of 10% forth on fermented product surface
II, continue fermentation more than 36h, i.e. obtain herbal medicine feed additive.
Anti-stress the most according to claim 6, the herbal medicine feed additive of raising production performance, it is characterised in that institute
Stating in microbial fermentation step, mixed bacteria I is: aspergillus niger 108~1010Cfu/mL, trichoderma reesei 108~1010cfu/mL;Mixed
Closing strain II is: yeast 109~1011Cfu/mL, bacillus subtilis 109~1011cfu/mL。
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CN103211112A (en) * | 2013-03-27 | 2013-07-24 | 广州绿州生物技术有限公司 | Chinese herbal medicine growth promotion feed additive for fowl and preparation method of feed additive |
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CN118078929A (en) * | 2024-04-26 | 2024-05-28 | 潍坊宇洋药业有限公司 | Livestock traditional Chinese veterinary medicine additive and preparation method thereof |
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