CN106177661A - 一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法 - Google Patents

一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法 Download PDF

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CN106177661A
CN106177661A CN201610667514.1A CN201610667514A CN106177661A CN 106177661 A CN106177661 A CN 106177661A CN 201610667514 A CN201610667514 A CN 201610667514A CN 106177661 A CN106177661 A CN 106177661A
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华梅
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Abstract

本发明涉及一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法，由如下重量份的原料药制成：土茯苓18‑22份、白蒺藜13‑17份、党参13‑17份、麦芽8‑12份、白术8‑12份、白芍8‑12份、半夏8‑12份、木贼8‑12份、当归8‑12份、蔓荆子8‑12份、羌活8‑12份、藁本8‑12份、山栀5‑7份、苍术5‑7份、神曲5‑7份、陈皮5‑7份、鸡内金2‑4份、细辛2‑4份、麻黄2‑4份。本发明具有疗效好，见效快，无副作用，制备工艺先进，制剂稳定性好，药物利用度高等优点；经临床验证，本发明治疗单纯疱疹病毒性角膜炎有效率为98%。

Description

一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法
技术领域
本发明涉及中药制药技术领域，特别是涉及一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法。
背景技术
单纯疱疹病毒性角膜炎是由于单纯疱疹病毒(HSV)感染引起的角膜炎症。单纯疱疹病毒是自然界广泛存在感染人类的传染性病毒。眼部HSV感染主要由HSV-1引起。HSV-1角膜炎是常见、严重的角膜病，居角膜病发病率和致盲原因的首位。它是由病毒感染、免疫与炎症反应参与、损伤角膜及眼表组织结构的复杂性眼病，也是当今危害严重的感染性眼病之一。
目前，治疗单纯疱疹病毒性角膜炎的药物存在疗效欠佳，副作用大，不易根治，治疗成本高的不足，因此研究一种疗效好，见效快，副作用小的治单纯疱疹病毒性角膜炎的中药组合物非常必要。
发明内容
本发明要解决的技术问题是：为解决现有技术的不足，本发明提供了一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法，本发明具有疗效好，见效快，无副作用，制备工艺先进，制剂稳定性好，药物利用度高等优点。
一种治疗单纯疱疹病毒性角膜炎的中药组合物，由如下重量份的原料药制成：土茯苓18-22份、白蒺藜13-17份、党参13-17份、麦芽8-12份、白术8-12份、白芍8-12份、半夏8-12份、木贼8-12份、当归8-12份、蔓荆子8-12份、羌活8-12份、藁本8-12份、山栀5-7份、苍术5-7份、神曲5-7份、陈皮5-7份、鸡内金2-4份、细辛2-4份、麻黄2-4份。
所述的治疗单纯疱疹病毒性角膜炎的中药组合物，其优选是：由如下重量份的原料药制成：土茯苓20份、白蒺藜15份、党参15份、麦芽10份、白术10份、白芍10份、半夏10份、木贼10份、当归10份、蔓荆子10份、羌活10份、藁本10份、山栀6份、苍术6份、神曲6份、陈皮6份、鸡内金3份、细辛3份、麻黄3份。
所述的治疗单纯疱疹病毒性角膜炎的中药组合物的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药党参、土茯苓、白蒺藜、党参、麦芽、白术、白芍、半夏、木贼、当归、蔓荆子、羌活、藁本、山栀、苍术、神曲、陈皮、鸡内金、细辛、麻黄备用；
（2）加入总原料药8-12倍重量的水浸泡1-1.5小时，加热煎煮1-3小时，过滤，药渣再加入4-6倍重量水，加热煎煮1-2小时，过滤，滤液合并，得上清液；
（3）上清液浓缩至相对密度为1.1-1.3时进喷雾干燥器，进风温度控制140-180℃，出风温度80-110℃，进料速度为1升每分钟，得喷雾干燥粉；
（4）将干燥粉剂按医药的常规方法制成口服液体制剂、胶囊剂或丸剂。
本发明与现有技术相比所具有的有益效果是：本发明是在传统中医理论和临床经验指导下，精选出各原料药及其配比，达到清肝泻火、疏风散邪的功效；本发明具有疗效好，见效快，无副作用，制备工艺先进，制剂稳定性好，药物利用度高等优点。
具体实施方式
实施例1：
一种治疗单纯疱疹病毒性角膜炎的中药组合物，由如下重量份的原料药制成：土茯苓20份、白蒺藜15份、党参15份、麦芽10份、白术10份、白芍10份、半夏10份、木贼10份、当归10份、蔓荆子10份、羌活10份、藁本10份、山栀6份、苍术6份、神曲6份、陈皮6份、鸡内金3份、细辛3份、麻黄3份。
所述的治疗单纯疱疹病毒性角膜炎的中药组合物的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药党参、土茯苓、白蒺藜、党参、麦芽、白术、白芍、半夏、木贼、当归、蔓荆子、羌活、藁本、山栀、苍术、神曲、陈皮、鸡内金、细辛、麻黄备用；
（2）加入总原料药8-12倍重量的水浸泡1-1.5小时，加热煎煮1-3小时，过滤，药渣再加入4-6倍重量水，加热煎煮1-2小时，过滤，滤液合并，得上清液；
（3）上清液浓缩至相对密度为1.1-1.3时进喷雾干燥器，进风温度控制140-180℃，出风温度80-110℃，进料速度为1升每分钟，得喷雾干燥粉；
（4）将干燥粉剂按医药的常规方法制成口服液体制剂、胶囊剂或丸剂。
实施例2：
一种治疗单纯疱疹病毒性角膜炎的中药组合物，由如下重量份的原料药制成：土茯苓18份、白蒺藜13份、党参13份、麦芽8份、白术8份、白芍8份、半夏8份、木贼8份、当归8份、蔓荆子8份、羌活8份、藁本8份、山栀5份、苍术5份、神曲5份、陈皮5份、鸡内金2份、细辛2份、麻黄2份。
所述的治疗单纯疱疹病毒性角膜炎的中药组合物的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药党参、土茯苓、白蒺藜、党参、麦芽、白术、白芍、半夏、木贼、当归、蔓荆子、羌活、藁本、山栀、苍术、神曲、陈皮、鸡内金、细辛、麻黄备用；
（2）加入总原料药8-12倍重量的水浸泡1-1.5小时，加热煎煮1-3小时，过滤，药渣再加入4-6倍重量水，加热煎煮1-2小时，过滤，滤液合并，得上清液；
（3）上清液浓缩至相对密度为1.1-1.3时进喷雾干燥器，进风温度控制140-180℃，出风温度80-110℃，进料速度为1升每分钟，得喷雾干燥粉；
（4）将干燥粉剂按医药的常规方法制成口服液体制剂、胶囊剂或丸剂。
实施例3：
一种治疗单纯疱疹病毒性角膜炎的中药组合物，由如下重量份的原料药制成：土茯苓22份、白蒺藜17份、党参17份、麦芽12份、白术12份、白芍12份、半夏12份、木贼12份、当归12份、蔓荆子12份、羌活12份、藁本12份、山栀7份、苍术7份、神曲7份、陈皮7份、鸡内金4份、细辛4份、麻黄4份。
所述的治疗单纯疱疹病毒性角膜炎的中药组合物的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药党参、土茯苓、白蒺藜、党参、麦芽、白术、白芍、半夏、木贼、当归、蔓荆子、羌活、藁本、山栀、苍术、神曲、陈皮、鸡内金、细辛、麻黄备用；
（2）加入总原料药8-12倍重量的水浸泡1-1.5小时，加热煎煮1-3小时，过滤，药渣再加入4-6倍重量水，加热煎煮1-2小时，过滤，滤液合并，得上清液；
（3）上清液浓缩至相对密度为1.1-1.3时进喷雾干燥器，进风温度控制140-180℃，出风温度80-110℃，进料速度为1升每分钟，得喷雾干燥粉；
（4）将干燥粉剂按医药的常规方法制成口服液体制剂、胶囊剂或丸剂。
实验例：
临床资料：采用本发明共治疗88例单纯疱疹病毒性角膜炎患者，年龄为13-55岁。
治疗方法：以本发明的口服液体制剂为例，口服一次10-20ml，一日2次，5天为一个疗程。
疗效评价标准：
治愈：黑睛星翳消失，荧光素染色阴性。症状消失。
好转：黑睛星翳减少或缩小，荧光素染色阳性。畏光刺痛、红赤流泪等症状减轻。
未愈：黑睛星翳无变化或加重，荧光素染色阳性，症状无改善。
治疗结果：采用本发明共治疗单纯疱疹病毒性角膜炎患者88例，经过1-3个疗程的治疗，其中治愈78例，好转8例，无效2例，有效率为98%；结果表明，本发明对治疗单纯疱疹病毒性角膜炎具有疗效好，见效快，无副作用，制备工艺先进，制剂稳定性好，药物利用度高等优点。

Claims (3)

1.一种治疗单纯疱疹病毒性角膜炎的中药组合物，其特征是：由如下重量份的原料药制成：土茯苓18-22份、白蒺藜13-17份、党参13-17份、麦芽8-12份、白术8-12份、白芍8-12份、半夏8-12份、木贼8-12份、当归8-12份、蔓荆子8-12份、羌活8-12份、藁本8-12份、山栀5-7份、苍术5-7份、神曲5-7份、陈皮5-7份、鸡内金2-4份、细辛2-4份、麻黄2-4份。
2.根据权利要求1所述的治疗单纯疱疹病毒性角膜炎的中药组合物，其特征是：由如下重量份的原料药制成：土茯苓20份、白蒺藜15份、党参15份、麦芽10份、白术10份、白芍10份、半夏10份、木贼10份、当归10份、蔓荆子10份、羌活10份、藁本10份、山栀6份、苍术6份、神曲6份、陈皮6份、鸡内金3份、细辛3份、麻黄3份。
3.根据权利要求1或2所述的治疗单纯疱疹病毒性角膜炎的中药组合物的制备方法，其特征是：包括以下步骤：
（1）按照所述重量份数称取原料药党参、土茯苓、白蒺藜、党参、麦芽、白术、白芍、半夏、木贼、当归、蔓荆子、羌活、藁本、山栀、苍术、神曲、陈皮、鸡内金、细辛、麻黄备用；
（2）加入总原料药8-12倍重量的水浸泡1-1.5小时，加热煎煮1-3小时，过滤，药渣再加入4-6倍重量水，加热煎煮1-2小时，过滤，滤液合并，得上清液；
（3）上清液浓缩至相对密度为1.1-1.3时进喷雾干燥器，进风温度控制140-180℃，出风温度80-110℃，进料速度为1升每分钟，得喷雾干燥粉；
（4）将干燥粉剂按医药的常规方法制成口服液体制剂、胶囊剂或丸剂。
CN201610667514.1A 2016-08-15 2016-08-15 一种治疗单纯疱疹病毒性角膜炎的中药组合物及其制备方法 Withdrawn CN106177661A (zh)

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CN102552777A (zh) * 2012-02-15 2012-07-11 刘静 治疗单纯疱疹病毒性角膜炎的药物及其制备方法
CN103800485A (zh) * 2014-03-12 2014-05-21 马丽 一种治疗单纯疱疹病毒性角膜炎的中药制剂
CN104906220A (zh) * 2015-07-07 2015-09-16 郑州德兴疱疹疾病研究所 一种治疗带状疱疹及单纯疱疹病毒性角膜炎的中药

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CN102552777A (zh) * 2012-02-15 2012-07-11 刘静 治疗单纯疱疹病毒性角膜炎的药物及其制备方法
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