CN106177045A - A kind of pharmaceutical composition with function for protecting liver and reducing enzyme activity and preparation method thereof and purposes - Google Patents
A kind of pharmaceutical composition with function for protecting liver and reducing enzyme activity and preparation method thereof and purposes Download PDFInfo
- Publication number
- CN106177045A CN106177045A CN201610715575.0A CN201610715575A CN106177045A CN 106177045 A CN106177045 A CN 106177045A CN 201610715575 A CN201610715575 A CN 201610715575A CN 106177045 A CN106177045 A CN 106177045A
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- CN
- China
- Prior art keywords
- weight portion
- radix
- herba artemisiae
- artemisiae scopariae
- concentrated solution
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Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/413—Gall bladder; Bile
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
The present invention relates to a kind of pharmaceutical composition with function for protecting liver and reducing enzyme activity and preparation method thereof and purposes.This pharmaceutical composition, its crude drug composition includes: Herba Artemisiae Scopariae 150～350 weight portion, Radix Gentianae 120～280 weight portion, Fructus Gardeniae 50～150 weight portion, Radix Scutellariae 15～35 weight portion, Radix Glycyrrhizae 30～70 weight portion, Radix Et Rhizoma Rhei 27～63 weight portion, Radix Paeoniae Alba (parched) 27～63 weight portion, Pien Tze Huang 0.1 10 weight portion.The present invention take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", jointly act on, thus play the effect for the treatment of acute and chronic hepatitis；This pharmaceutical composition, only includes eight kinds of crude drug, and composition is simple, cost is relatively low.
Description
Technical field
The invention belongs to drug world, be specifically related to a kind of pharmaceutical composition treating acute and chronic hepatitis and system thereof
Preparation Method and purposes.
Background technology
Viral hepatitis be by first, second, third, the inflammation disease that causes of fourth, hepatitis E virus, main table clinically
Being now weak, loss of appetite, Nausea and vomiting, hepatomegaly and liver function injury, some patients can have jaundice and heating, have biography
Metachromia is compared with strong, route of transmission wide general, sickness rate relatively high complicated, popular.As a example by China, the most about increase newly 50～
600000 Patients with Viral Hepatitis.All hepatitis viruss can cause acute hepatitis, additionally, second, third, hepatitis D virus also can draw
Playing chronic hepatitis, chronic hepatitis can cause liver cirrhosis, liver failure and hepatocarcinoma.
Chinese patent literature CN104524054A discloses: a kind of Chinese medicinal herbs decoction treating hepatitis A, by
Following raw material of Chinese medicine is made: Radix Trichosanthis 10g, Herba Patriniae 10g, Radix Bupleuri 12g, Semen Litchi 10g, Fructus Gardeniae 15g, Radix Paeoniae Alba 12g, Radix Scrophulariae
12g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Et Rhizoma Rhei 18g, Rhizoma Paridis 10g, Herba Andrographis 10g, Radix Isatidis 9g, Cortex Dictamni 18g, Gypsum Fibrosum 20g, Aerugo
0.5g, Radix Cynanchi Atrati 6g, Herba Hedyotidis Diffusae 30g, Radix Glycyrrhizae 10g, Herba Scutellariae Barbatae 10g, Radix Semiaquilegiae 15g, Flos Carthami 10g, Radix Salviae Miltiorrhizae 10g, Herba Leonuri
Grass 20g, Cortex Eucommiae 15g, Rhizoma Homalomenae 30g, Galla Chinensis 15g, Radix Angelicae Sinensis 10g, Rhizoma Corydalis 10g, Flos Rosae Chinensis 10g, Cortex Phellodendri 12g, Radix Gentianae
8g, Radix Scutellariae 10g, Herba Taraxaci 15g, Herba Lysimachiae 15g, Poria 10g, Polyporus 10g, Radix Rehmanniae Preparata 10g, Os Gallus Domesticus 10g, Endothelium Corneum Gigeriae Galli 15g,
Fructus Crataegi 10g, Herba Artemisiae Scopariae 20g, Radix Polygoni Multiflori 20g；This Chinese medicinal herbs decoction has the effect such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.But, above-mentioned group
Compound exists and forms the shortcomings such as complicated, relatively costly, thus limits its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost treatment acute and chronic sick
The medicine of virus hepatitis is significant.
Summary of the invention
Therefore, the present invention provide one to treat therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost treatment
The pharmaceutical composition of acute and chronic hepatitis, and then its preparation method and purposes are provided.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of pharmaceutical composition treating acute and chronic hepatitis, its crude drug composition to include:
Herba Artemisiae Scopariae 150～350 weight portion, Radix Gentianae 120～280 weight portion, Fructus Gardeniae 50～150 weight portion, Radix Scutellariae 15～35 weight
Amount part, Radix Glycyrrhizae 30～70 weight portion, Radix Et Rhizoma Rhei 27～63 weight portion, Radix Paeoniae Alba (parched) 27～63 weight portion, Pien Tze Huang 0.1-10 weight portion；
Its preparation method comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation at least 1 time, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicine
Slag；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and
On the basis of the gross weight of described Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water at least 1 time, add the water of at least 2 weight times amount every time
At least extract 1h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-at described filtrate A is concentrated into 70-80 DEG C
The concentrated solution A of 1.20, adding ethanol to alcohol content in described concentrated solution A is 50～90%, stands, filters, obtain liquor B, will
At described liquor B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction at least 1
Secondary, add every time the volumetric concentration of 6～10 weight times amount be 50～90% ethanol water extract at least 1h, filter, merge
Extracting solution, obtains liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds at least 1
The water of volume times amount, filters, obtains filtrate D, the concentrated solution of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C
D；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 20-50%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, mixed
Close uniformly, to obtain final product.
Preferably, the pharmaceutical composition of the present invention above-mentioned treatment acute and chronic hepatitis, its crude drug composition includes:
Herba Artemisiae Scopariae 200～300 weight portion, Radix Gentianae 160～240 weight portion, Fructus Gardeniae 75～125 weight portion, Radix Scutellariae 20～30 weight
Amount part, Radix Glycyrrhizae 40～60 weight portion, Radix Et Rhizoma Rhei 36～54 weight portion, Radix Paeoniae Alba (parched) 36～54 weight portion, Pien Tze Huang 1-7 weight portion.
It is further preferred that the pharmaceutical composition of the present invention above-mentioned treatment acute and chronic hepatitis, its crude drug forms
Including:
Herba Artemisiae Scopariae 250 weight portion, Radix Gentianae 200 weight portion, Fructus Gardeniae 100 weight portion, Radix Scutellariae 25 weight portion, Radix Glycyrrhizae 50 weight portion,
Radix Et Rhizoma Rhei 45 weight portion, Radix Paeoniae Alba (parched) 45 weight portion, Pien Tze Huang 4 weight portion；Or
Herba Artemisiae Scopariae 200 weight portion, Radix Gentianae 240 weight portion, Fructus Gardeniae 75 weight portion, Radix Scutellariae 30 weight portion, Radix Glycyrrhizae 40 weight portion, big
Yellow 54 weight portions, Radix Paeoniae Alba (parched) 36 weight portion, Pien Tze Huang 7 weight portion；Or
Herba Artemisiae Scopariae 300 weight portion, Radix Gentianae 160 weight portion, Fructus Gardeniae 125 weight portion, Radix Scutellariae 20 weight portion, Radix Glycyrrhizae 60 weight portion,
Radix Et Rhizoma Rhei 36 weight portion, Radix Paeoniae Alba (parched) 54 weight portion, Pien Tze Huang 1 weight portion；Or
Herba Artemisiae Scopariae 220 weight portion, Radix Gentianae 190 weight portion, Fructus Gardeniae 110 weight portion, Radix Scutellariae 26 weight portion, Radix Glycyrrhizae 51 weight portion,
Radix Et Rhizoma Rhei 47 weight portion, Radix Paeoniae Alba (parched) 39 weight portion, Pien Tze Huang 5 weight portion.
It is further preferred that the pharmaceutical composition of the present invention above-mentioned treatment acute and chronic hepatitis, its preparation method bag
Include following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 1～3 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and
On the basis of the gross weight of described Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 1～3 times, the water every time adding 6～10 weight times amount carries
Take 1～3h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C
Concentrated solution A, adding ethanol to alcohol content in described concentrated solution A is 60～80%, stands, filters, obtain liquor B, by described filter
At liquid B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 1～3
Secondary, add the ethanol water extraction 1～3h that volumetric concentration is 60～80% of 6～10 weight times amount every time, filter, merging carries
Take liquid, obtain liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, add 1～3 bodies
The water of long-pending times amount, filters, obtains filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, mixed
Close uniformly, to obtain final product.
The present invention also provides for the preparation method of the pharmaceutical composition of a kind of above-mentioned treatment acute and chronic hepatitis, including with
Lower step:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation at least 1 time, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicine
Slag；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and
On the basis of the gross weight of described Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water at least 1 time, add the water of at least 2 weight times amount every time
At least extract 1h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-at described filtrate A is concentrated into 70-80 DEG C
The concentrated solution A of 1.20, adding ethanol to alcohol content in described concentrated solution A is 50～90%, stands, filters, obtain liquor B, will
At described liquor B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction at least 1
Secondary, add every time the volumetric concentration of 6～10 weight times amount be 50～90% ethanol water extract at least 1h, filter, merge
Extracting solution, obtains liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds at least 1
The water of volume times amount, filters, obtains filtrate D, the concentrated solution of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C
D；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 20-50%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, mixed
Close uniformly, to obtain final product.
Preferably, the preparation method of the pharmaceutical composition of the present invention above-mentioned treatment acute and chronic hepatitis, including following
Step:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 1～3 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and
On the basis of the gross weight of described Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 1～3 times, the water every time adding 6～10 weight times amount carries
Take 1～3h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C
Concentrated solution A, adding ethanol to alcohol content in described concentrated solution A is 60～80%, stands, filters, obtain liquor B, by described filter
At liquid B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 1～3
Secondary, add the ethanol water extraction 1～3h that volumetric concentration is 60～80% of 6～10 weight times amount every time, filter, merging carries
Take liquid, obtain liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, add 1～3 bodies
The water of long-pending times amount, filters, obtains filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, mixed
Close uniformly, to obtain final product.
It is further preferred that the preparation method of the pharmaceutical composition of the present invention above-mentioned treatment acute and chronic hepatitis, bag
Include following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 2 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and
On the basis of the gross weight of described Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 2 times, add the water extraction 2h of 8 weight times amount, mistake every time
Filter, united extraction liquid, obtain filtrate A, the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to
Adding ethanol to alcohol content in described concentrated solution A is 70%, stands, filters, obtain liquor B, described liquor B is concentrated into 40-50
At DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 2 times,
The ethanol water that volumetric concentration is 70% every time adding 8 weight times amount extracts 2h, filters, united extraction liquid, obtains liquor C,
The concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds the water of 2 volume times amount, filters,
Obtain filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, mixed
Close uniformly, to obtain final product.
The present invention also provides for including the preparation of aforementioned pharmaceutical compositions or including the medicine that above-mentioned preparation method prepares
The preparation of compositions,
Described pharmaceutical composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule
Agent, powder, mixture, pill, granule, solution, syrup, soft extract or patch.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, anticorrosion
Agent, substrate etc..Filler includes: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.；Collapse
Solution agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low replacement hydroxyl
Third cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, dioxy
SiClx etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Bonding
Agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: saccharin sodium, Aspartane, sugarcane
Sugar, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes: parabens, benzoic acid,
Sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the eucalyptus oil of acetic acid chloroethene etc.；Substrate includes: PEG6000,
PEG4000, insect wax etc..
The present invention also provides for aforementioned pharmaceutical compositions, above-mentioned preparation method prepares pharmaceutical composition or above-mentioned medicine
The application in the medicine of preparation treatment acute and chronic hepatitis of the preparation of compositions.
The present invention also provides for aforementioned pharmaceutical compositions, above-mentioned preparation method prepares pharmaceutical composition or above-mentioned medicine
The application in preparation has the medicine of function for protecting liver and reducing enzyme activity of the preparation of compositions.
Compared with prior art, technical scheme has the advantage that
[Herba Artemisiae Scopariae] cold nature, bitter in the mouth, micro-pungent, return spleen channel, stomach warp, Liver Channel, gallbladder meridian, there is clearing away damp-heat, effect of jaundice eliminating subcutaneous ulcer.
[Radix Gentianae] is cold in nature, bitter in the mouth, returns Liver Channel, gallbladder meridian, has clear wet scorching, effect of removing fire from the liver.
[Fructus Gardeniae] is cold in nature, bitter in the mouth, and GUIXIN warp, lung meridian, stomach through, tri-jiao channel, have clear wet liver-fire, removing heat from blood, removing toxic substances, dampness removing
Effect.
[Radix Scutellariae] is cold in nature, bitter in the mouth, returns spleen channel, lung meridian, small intestine meridian, gallbladder meridian, large intestine channel, has effect of heat clearing away.
[Radix Glycyrrhizae] property is put down, sweet in the mouth, and GUIXIN warp, spleen channel, lung meridian, stomach warp have effect of tonification.
[Radix Et Rhizoma Rhei] is cold in nature, bitter in the mouth, returns Liver Channel, spleen channel, stomach warp, large intestine channel, pericardium channel, has the effect under rushing down.
[Radix Paeoniae Alba (parched)] cold nature, bitter in the mouth, acid, return Liver Channel, spleen channel, there is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, the merit of astringing YIN to stop sweating
Effect.
Pien Tze Huang is that kind protected by country-level Chinese medicine, use the rare Chinese medicine such as Moschus, Calculus Bovis, Fel Serpentis, Radix Notoginseng refined and
Becoming, have heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain, clinic is usually used in treating bacterial infection disease, viral liver
The diseases such as inflammation, bronchitis, malignant tumor.
(1) pharmaceutical composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine mutually it
Between proportioning, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", jointly act on, thus it be anxious to play treatment
The effect of chronic viral hepatitis；
(2) pharmaceutical composition of the present invention, only includes eight kinds of crude drug, and composition is simple, cost is relatively low.
Detailed description of the invention
In following example of the present invention and experimental example, all crude drug, reagent and solvent are commercially available product.
Embodiment 1
The crude drug of the pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis consists of:
Herba Artemisiae Scopariae 250g, Radix Gentianae 200g, Fructus Gardeniae 100g, Radix Scutellariae 25g, Radix Glycyrrhizae 50g, Radix Et Rhizoma Rhei 45g, Radix Paeoniae Alba (parched) 45g, Pien Tze Huang
4g；
The preparation method of this pharmaceutical composition, comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight, with water vapour distillation 2 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and institute
On the basis of stating the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 2 times, add the water extraction 2h of 8 weight times amount, mistake every time
Filter, united extraction liquid, obtain filtrate A, the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to
Adding ethanol to alcohol content in described concentrated solution A is 70%, stands more than 12h, filters, obtain liquor B, described liquor B concentrated
At 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 2 times, often
The ethanol water that volumetric concentration is 70% of secondary addition 8 weight times amount extracts 2h, filters, united extraction liquid, obtains liquor C, will
Described liquor C be concentrated into 70-80 DEG C at the concentrated solution C of relative density 1.15-1.20, add the water of 2 volume times amount, filter,
Filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight, mixing
Uniformly, to obtain final product..
The pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis adds customary adjuvant, according to common process, system
Piece agent.
Embodiment 2
The crude drug of the pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis consists of:
Herba Artemisiae Scopariae 200g, Radix Gentianae 240g, Fructus Gardeniae 75g, Radix Scutellariae 30g, Radix Glycyrrhizae 40g, Radix Et Rhizoma Rhei 54g, Radix Paeoniae Alba (parched) 36g, Pien Tze Huang 7g；
The preparation method of this pharmaceutical composition, comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight, with water vapour distillation 1 time, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and institute
On the basis of stating the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 3 times, add the water extraction 3h of 6 weight times amount, mistake every time
Filter, united extraction liquid, obtain filtrate A, the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to
Adding ethanol to alcohol content in described concentrated solution A is 60%, stands more than 12h, filters, obtain liquor B, described liquor B concentrated
At 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 1 time, often
The ethanol water that volumetric concentration is 60% of secondary addition 10 weight times amount extracts 3h, filters, united extraction liquid, obtains liquor C, will
Described liquor C be concentrated into 70-80 DEG C at the concentrated solution C of relative density 1.15-1.20, add the water of 1 volume times amount, filter,
Filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight, mixing
Uniformly, to obtain final product.
The pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis adds customary adjuvant, according to common process, system
Become capsule.
Embodiment 3
The crude drug of the pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis consists of:
Herba Artemisiae Scopariae 300g, Radix Gentianae 160g, Fructus Gardeniae 125g, Radix Scutellariae 20g, Radix Glycyrrhizae 60g, Radix Et Rhizoma Rhei 36g, Radix Paeoniae Alba (parched) 54g, Pien Tze Huang
1g；
The preparation method of this pharmaceutical composition, comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight, with water vapour distillation 3 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and institute
On the basis of stating the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 1 time, add the water extraction 1h of 10 weight times amount, mistake every time
Filter, united extraction liquid, obtain filtrate A, the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to
Adding ethanol to alcohol content in described concentrated solution A is 80%, stands more than 12h, filters, obtain liquor B, described liquor B concentrated
At 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 3 times, often
The ethanol water that volumetric concentration is 80% of secondary addition 6 weight times amount extracts 1h, filters, united extraction liquid, obtains liquor C, will
Described liquor C be concentrated into 70-80 DEG C at the concentrated solution C of relative density 1.15-1.20, add the water of 3 volume times amount, filter,
Filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight, mixing
Uniformly, to obtain final product.
The pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis adds customary adjuvant, according to common process, system
Become powder.
Embodiment 4
The crude drug of the pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis consists of:
Herba Artemisiae Scopariae 220g, Radix Gentianae 190g, Fructus Gardeniae 110g, Radix Scutellariae 26g, Radix Glycyrrhizae 51g, Radix Et Rhizoma Rhei 47g, Radix Paeoniae Alba (parched) 39g, Pien Tze Huang
5g；
The preparation method of this pharmaceutical composition, comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight, with water vapour distillation 2 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and institute
On the basis of stating the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 3 times, add the water extraction 2.5h of 9 weight times amount, mistake every time
Filter, united extraction liquid, obtain filtrate A, the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to
Adding ethanol to alcohol content in described concentrated solution A is 75%, stands more than 12h, filters, obtain liquor B, described liquor B concentrated
At 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 2 times, often
The ethanol water that volumetric concentration is 65% of secondary addition 7 weight times amount extracts 2.5h, filters, united extraction liquid, obtains liquor C,
The concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds the water of 2 volume times amount, filters,
Obtain filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor,
The solid content adjusting described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight, mixing
Uniformly, to obtain final product.
The pharmaceutical composition of the present embodiment treatment acute and chronic hepatitis adds customary adjuvant, according to common process, system
Become oral liquid.
Experimental example 1The pharmaceutical composition of the present invention research to acute and chronic hepatitis therapeutical effect
1, experiment material
Pien Tze Huang is provided by Zhongzhou Pianziguang Pharmaceutical Industry Co., Ltd., and remaining crude drug is commercially available product.
2, experimental technique
2.1 for reagent thing
Acute viral hepatitis group and chronic viral hepatitis group all take the pharmaceutical composition of embodiment 1 preparation.
2.2 experiment packets
According to the relevant criterion in " Diagnosis of Viral Hapatitis standard ", selection was gone to a doctor in March, 2012 in February, 2014
Various acute and chronic hepatitis patient, makes a definite diagnosis into group.Wherein, acute viral hepatitis group 98 example, chronic viral hepatitis group
120 examples.Patient age 18-68 year, 37.3 years old mean age.All cases all get rid of serious hepatorenal disease, malignant tumor etc.
Serious systemic disease.
2.3 medication
Disable other drug before taking medicine, take the pharmaceutical composition of embodiment 1 preparation, three times a day, each 1g, take continuously
With 28 days.
3, experimental data detection and process
After taking medicine 28 days, all patients are carried out detection and the observation of clinical symptoms of liver function, it is judged that clinical efficacy.
Symptom assessment standard: (1) is effective: the jaundice of experimenter, clinical symptoms are wholly absent, liver function index is just recovering
Often；(2) effective: experimenter's clinical symptoms is obviously improved, and jaundice substantially reduces, liver function index reduces amplitude more than 50%；(3)
Invalid: not reducing with contrast jaundice before treatment, clinical symptoms and liver function index are unchanged or increase the weight of.Wherein, obvious effective rate and having
Efficiency sum is referred to as total effective rate.
4, experimental result
The total effective rate of acute viral hepatitis group and chronic viral hepatitis group is as shown in table 1.
The total effective rate of 1 liang of table group patient
As shown in Table 1, the treatment total effective rate of acute viral hepatitis is by the pharmaceutical composition of embodiment 1 preparation
93.9%, the treatment total effective rate to chronic viral hepatitis is 86.6%.
Additionally, observation indicate that of clinical symptoms, the pharmaceutical composition of embodiment 1 preparation, acute disease can be effectively improved
Virus hepatitis and patients with chronic viral hepatitis appearance all yellow, breast side of body overflows, feel sick, poor appetite, yellowish or reddish urine, the clinical condition such as weak
Shape, has significant the liver protecting and ALT lowering effect, has no adverse reaction in whole therapeutic process.
In sum, the pharmaceutical composition of the present invention has significant therapeutic effect to acute and chronic hepatitis, permissible
Medicine as potential treatment acute and chronic hepatitis.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right
For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or
Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or
Change among still in the protection domain of the invention.
Claims (10)
1. a pharmaceutical composition, it is characterised in that its crude drug composition includes:
Herba Artemisiae Scopariae 150～350 weight portion, Radix Gentianae 120～280 weight portion, Fructus Gardeniae 50～150 weight portion, Radix Scutellariae 15～35 weight portion,
Radix Glycyrrhizae 30～70 weight portion, Radix Et Rhizoma Rhei 27～63 weight portion, Radix Paeoniae Alba (parched) 27～63 weight portion, Pien Tze Huang 0.1-10 weight portion；
Its preparation method comprises the following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation at least 1 time, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and described
On the basis of the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water at least 1 time, add the water of at least 2 weight times amount at least every time
Extract 1h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C
Concentrated solution A, adding ethanol to alcohol content in described concentrated solution A is 50～90%, stands, filters, obtain liquor B, by described filter
At liquid B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction at least 1 time,
Add every time the volumetric concentration of 6～10 weight times amount be 50～90% ethanol water extract at least 1h, filter, united extraction
Liquid, obtains liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds at least 1 volume
The water of times amount, filters, obtains filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor, adjust
The solid content of described mixed liquor is 20-50%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, and mixing is all
Even, to obtain final product.
Pharmaceutical composition the most according to claim 1, it is characterised in that its crude drug composition includes:
Herba Artemisiae Scopariae 200～300 weight portion, Radix Gentianae 160～240 weight portion, Fructus Gardeniae 75～125 weight portion, Radix Scutellariae 20～30 weight portion,
Radix Glycyrrhizae 40～60 weight portion, Radix Et Rhizoma Rhei 36～54 weight portion, Radix Paeoniae Alba (parched) 36～54 weight portion, Pien Tze Huang 1-7 weight portion.
Pharmaceutical composition the most according to claim 2, it is characterised in that its crude drug composition includes:
Herba Artemisiae Scopariae 250 weight portion, Radix Gentianae 200 weight portion, Fructus Gardeniae 100 weight portion, Radix Scutellariae 25 weight portion, Radix Glycyrrhizae 50 weight portion, Radix Et Rhizoma Rhei
45 weight portions, Radix Paeoniae Alba (parched) 45 weight portion, Pien Tze Huang 4 weight portion；Or
Herba Artemisiae Scopariae 200 weight portion, Radix Gentianae 240 weight portion, Fructus Gardeniae 75 weight portion, Radix Scutellariae 30 weight portion, Radix Glycyrrhizae 40 weight portion, Radix Et Rhizoma Rhei 54
Weight portion, Radix Paeoniae Alba (parched) 36 weight portion, Pien Tze Huang 7 weight portion；Or
Herba Artemisiae Scopariae 300 weight portion, Radix Gentianae 160 weight portion, Fructus Gardeniae 125 weight portion, Radix Scutellariae 20 weight portion, Radix Glycyrrhizae 60 weight portion, Radix Et Rhizoma Rhei
36 weight portions, Radix Paeoniae Alba (parched) 54 weight portion, Pien Tze Huang 1 weight portion；Or
Herba Artemisiae Scopariae 220 weight portion, Radix Gentianae 190 weight portion, Fructus Gardeniae 110 weight portion, Radix Scutellariae 26 weight portion, Radix Glycyrrhizae 51 weight portion, Radix Et Rhizoma Rhei
47 weight portions, Radix Paeoniae Alba (parched) 39 weight portion, Pien Tze Huang 5 weight portion.
4. according to the pharmaceutical composition described in any one of claim 1-3, it is characterised in that its preparation method includes following step
Rapid:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 1～3 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and described
On the basis of the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 1～3 times, add the water extraction 1 of 6～10 weight times amount every time
～3h, filtering, united extraction liquid, obtain filtrate A, at described filtrate A is concentrated into 70-80 DEG C, relative density 1.15-1.20 is dense
Contracting liquid A, adding ethanol to alcohol content in described concentrated solution A is 60～80%, stands, filters, obtain liquor B, by described liquor B
At being concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 1～3 times, often
The volumetric concentration of secondary addition 6～10 weight times amount is the ethanol water extraction 1～3h of 60～80%, filters, united extraction liquid,
Obtain liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, add 1～3 volume times amount
Water, filter, obtain filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor, adjust
The solid content of described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, and mixing is all
Even, to obtain final product.
5. the preparation method of the pharmaceutical composition described in an any one of claim 1-4, it is characterised in that include following step
Rapid:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation at least 1 time, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and described
On the basis of the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water at least 1 time, add the water of at least 2 weight times amount at least every time
Extract 1h, filter, united extraction liquid, obtain filtrate A, relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C
Concentrated solution A, adding ethanol to alcohol content in described concentrated solution A is 50～90%, stands, filters, obtain liquor B, by described filter
At liquid B is concentrated into 40-50 DEG C, relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction at least 1 time,
Add every time the volumetric concentration of 6～10 weight times amount be 50～90% ethanol water extract at least 1h, filter, united extraction
Liquid, obtains liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, adds at least 1 volume
The water of times amount, filters, obtains filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor, adjust
The solid content of described mixed liquor is 20-50%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, and mixing is all
Even, to obtain final product.
The preparation method of pharmaceutical composition the most according to claim 5, it is characterised in that comprise the following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 1～3 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and described
On the basis of the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 1～3 times, add the water extraction 1 of 6～10 weight times amount every time
～3h, filter, united extraction liquid, obtain filtrate A,
The concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, adds in described concentrated solution A
Ethanol to alcohol content is 60～80%, stands, and filters, obtains liquor B, and at described liquor B is concentrated into 40-50 DEG C, relative density is
The concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 1～3 times, often
The volumetric concentration of secondary addition 6～10 weight times amount is the ethanol water extraction 1～3h of 60～80%, filters, united extraction liquid,
Obtain liquor C, the concentrated solution C of relative density 1.15-1.20 at described liquor C is concentrated into 70-80 DEG C, add 1～3 volume times amount
Water, filter, obtain filtrate D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor, adjust
The solid content of described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, and mixing is all
Even, to obtain final product.
The preparation method of pharmaceutical composition the most according to claim 6, it is characterised in that comprise the following steps:
Take the Herba Artemisiae Scopariae of selected weight portion, with water vapour distillation 2 times, respectively Herba Artemisiae Scopariae volatile oil and Herba Artemisiae Scopariae medicinal residues；
Take the Fructus Gardeniae of selected weight portion, Radix Glycyrrhizae and Radix Paeoniae Alba (parched), add described Herba Artemisiae Scopariae medicinal residues, with Fructus Gardeniae, Radix Glycyrrhizae, Radix Paeoniae Alba (parched) and described
On the basis of the gross weight of Herba Artemisiae Scopariae medicinal residues, the heating and refluxing extraction that adds water 2 times, add the water extraction 2h of 8 weight times amount every time, filter,
United extraction liquid, obtains filtrate A, and the concentrated solution A of relative density 1.15-1.20 at described filtrate A is concentrated into 70-80 DEG C, to institute
Stating addition ethanol to alcohol content in concentrated solution A is 70%, stands, filters, obtain liquor B, described liquor B is concentrated into 40-50 DEG C
Lower relative density is the concentrated solution B of 1.20-1.25；
Take Radix Gentianae and the Radix Scutellariae of selected weight portion, on the basis of the gross weight of Radix Gentianae and Radix Scutellariae, heating and refluxing extraction 2 times, every time
The ethanol water that volumetric concentration is 70% adding 8 weight times amount extracts 2h, filters, united extraction liquid, obtains liquor C, by institute
State the concentrated solution C of relative density 1.15-1.20 at liquor C is concentrated into 70-80 DEG C, add the water of 2 volume times amount, filter, obtain filter
Liquid D, the concentrated solution D of relative density 1.20-1.25 at described filtrate D is concentrated into 40-50 DEG C；
Take the Radix Et Rhizoma Rhei of selected weight portion, pulverize, obtain Radix Et Rhizoma Rhei powder and mince；
Described concentrated solution B and described concentrated solution D is merged, adds described Radix Et Rhizoma Rhei powder and mince, mix homogeneously, obtain mixed liquor, adjust
The solid content of described mixed liquor is 30-40%, is subsequently adding described Herba Artemisiae Scopariae volatile oil and the Pien Tze Huang of selected weight portion, and mixing is all
Even, to obtain final product.
8. include the preparation of the pharmaceutical composition described in any one of claim 1-4 or include any one of claim 5-7 institute
The preparation of the pharmaceutical composition that the preparation method stated prepares, it is characterised in that
Described pharmaceutical composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule, dissipates
Agent, mixture, pill, granule, solution, syrup, soft extract or patch.
9. the pharmaceutical composition described in any one of claim 1-4, the preparation method described in any one of claim 5-7 are prepared into
The preparation of the pharmaceutical composition described in the pharmaceutical composition arrived or claim 8 is at preparation treatment acute and chronic hepatitis
Application in medicine.
10. prepared by the pharmaceutical composition described in any one of claim 1-4, the preparation method described in any one of claim 5-7
The preparation of the pharmaceutical composition described in the pharmaceutical composition obtained or claim 8 has the medicine of function for protecting liver and reducing enzyme activity in preparation
Application in thing.
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|---|---|---|---|---|
| CN102692477A (en) * | 2012-06-14 | 2012-09-26 | 漳州片仔癀药业股份有限公司 | Medicinal composition used for treating fatty liver and quality detection method thereof |
| CN102727619A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparations thereof |
| CN102727620A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparation method thereof |
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- 2016-08-24 CN CN201610715575.0A patent/CN106177045A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102692477A (en) * | 2012-06-14 | 2012-09-26 | 漳州片仔癀药业股份有限公司 | Medicinal composition used for treating fatty liver and quality detection method thereof |
| CN102727619A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparations thereof |
| CN102727620A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparation method thereof |
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