CN106176378A - A kind of anticaries and reparation dental caries toothpaste and the preparation method of collutory - Google Patents
A kind of anticaries and reparation dental caries toothpaste and the preparation method of collutory Download PDFInfo
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- CN106176378A CN106176378A CN201610646479.5A CN201610646479A CN106176378A CN 106176378 A CN106176378 A CN 106176378A CN 201610646479 A CN201610646479 A CN 201610646479A CN 106176378 A CN106176378 A CN 106176378A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention relates to a kind of anticaries and repair dental caries toothpaste and the preparation method of collutory, belonging to Dental Erosion technical field.The present invention is with the Radix Angelicae Dahuricae, Radix Ampelopsis, Rhizoma Cyperi, Herba Asari, Rhizoma Chuanxiong is that Chinese medicinal powder prepared by raw material, and by itself and toothpaste abrasives silicon dioxide, dopamine hydrochloride, stevioside, sorbitol etc. prepare anticaries in vacuum Manufacturing medicine extract machine and repair dental caries toothpaste, and with sodium bicarbonate, three hypophosphite monohydrate hydrogen dipotassiums, calcium chloride, sodium chloride is raw material, with trishydroxymethylaminomethane and salt acid for adjusting pH after mix homogeneously, prepare anticaries and repair dental caries collutory, the present invention utilizes the method for biomimetic mineralization to stick to dentin surface by dopamine oxidation auto polymerization, hydroxyapatite layer is deposited as bridge, realize Dentinal remineralization, form the protective layer of one layer of firm densification, can effectively anticaries and repair dental caries.
Description
Technical field
The present invention relates to a kind of anticaries and repair dental caries toothpaste and the preparation method of collutory, belonging to Dental Erosion skill
Art field.
Background technology
During China's population is still in slowly increasing, along with the raising of expanding economy Yu people's schooling
And to the attention given birth to children, the most visible in terms of the dental caries control of child, have been obtained for certain success.Dental caries is as being permitted
The latency of the most serious oral diseases, the most early finds that it exists, and control more early will obtain the biggest effect, therefore with treatment
The various common oral pathogenic bacterium causing dental caries are studied the most necessary.While controlling oral cavity pathogen, for
The early stage dental caries that it is caused, it is also desirable to make impaired glaze be repaired as early as possible, preferably to subtract by the method promoting remineralization
The harm that low dental caries causes.
Dental caries is a kind of chronic disease that hard tooth tissue structure is gradually destroyed, affects the life of people all the time
Live, endanger the oral health of the mankind.The generation of dental caries from the beginning of adamantine demineralization, the therefore adamantine repairing research of demineralization
For the prevention of dental caries with treat significant.Although present oral cavity material itself lacks for repairing cavity or tooth
Damage more effective, but be unable to reach the purpose preventing dental caries from again occurring.Preferably dental prosthetic material composition, structure and
The aspects such as character should be similar to dental tissue, so the hydroxyapatite material similar with enamel composition is Dental Erosion
Ideal material.
When after the whole corrosion of enamel, dentin will be exposed, cause the problem such as hemodia, dental caries.Therefore, at tooth originally
Matter surface re-forms the hydroxyapatite protective layer of one layer of firm densification, it appears particularly important.
Summary of the invention
The technical problem to be solved: lack for repairing cavity or tooth for present oral cavity material itself
Damaging more effective, but be unable to reach the problem preventing dental caries from again occurring, the present invention has carried a kind of anticaries and has repaired dental caries
Teeth cream and the preparation method of collutory, the present invention prepares Chinese medicinal powder with the Radix Angelicae Dahuricae, Radix Ampelopsis, Rhizoma Cyperi, Herba Asari, Rhizoma Chuanxiong for raw material,
And by itself and toothpaste abrasives silicon dioxide, dopamine hydrochloride, stevioside, sorbitol etc. prepares pre-in vacuum Manufacturing medicine extract machine
Anti-dental caries and reparation dental caries toothpaste, and with sodium bicarbonate, three hypophosphite monohydrate hydrogen dipotassiums, calcium chloride, sodium chloride as raw material, mixing is all
Even rear trishydroxymethylaminomethane and salt acid for adjusting pH, prepare anticaries and repair dental caries collutory, and the present invention utilizes imitative
The method of rawore sticks to dentin surface by dopamine oxidation auto polymerization, deposits hydroxyapatite layer as bridge,
Realize Dentinal remineralization, form the protective layer of one layer of firm densification, can effectively anticaries and reparation dental caries.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
(1) 36 ~ 37g sodium silicate is weighed respectively, 11 ~ 12g sodium sulfate, add in 950 ~ 1000mL deionized water, with 200 ~ 300r/
Min stirs 15 ~ 20min, obtains mixed liquor, and mixed liquor is warming up to 80 ~ 85 DEG C, and is 12% sulfuric acid solution regulation with mass fraction
Mixed liquor pH value is 2.5 ~ 3.5, keeps temperature continuously stirred 60 ~ 90min, after standing 30 ~ 40min, proceeds in centrifuge, with
5000 ~ 6000r/min centrifugation, collects precipitation, and being washed with deionized and being precipitated to cleaning mixture is neutrality, precipitation is placed in dry
In dry case, it is dried at 105 ~ 110 DEG C to constant weight, dried product is loaded in ball mill, with 300 ~ 400r/min ball milling 1
~ 2h, obtains toothpaste abrasives silicon dioxide, standby；
(2) 20 ~ 25g Radix Angelicae Dahuricae dry root, 20 ~ 25g Radix Ampelopsis dried root, 20 ~ 25g Rhizoma Cyperi dry rhizome, 20 ~ 25g are weighed respectively
Herba Asari dry rhizome, 20 ~ 25g Rhizoma Chuanxiong dry root, add in pulverizer and pulverize, and crosses 200 mesh sieves, and the powder after sieving adds goal
In grinding machine, with 200 ~ 300r/min ball milling 1 ~ 2h, after ball milling is uniform, obtain Chinese medicinal powder, standby；
(3) 10 ~ 12g stevioside is weighed, 1 ~ 2g Mint Essence, 0.5 ~ 0.8g potassium sorbate, 0.03 ~ 0.05g dopamine hydrochloride,
Add in 18 ~ 20mL deionized water, after being uniformly mixed with 300 ~ 400r/min, mix addition vacuum with 15 ~ 20g sorbitol
In Manufacturing medicine extract machine, stir 3 ~ 5min with 500 ~ 600r/min, obtain mixing liquid material；
(4) toothpaste abrasives silicon dioxide prepared by 40 ~ 45g above-mentioned steps (1), 1 ~ 2g cocamidopropyl propyl amide Radix Betae are weighed
Alkali, 1 ~ 2g xanthan gum, Chinese medicinal powder prepared by 5 ~ 6g above-mentioned steps (2), add in food blender, mix homogeneously obtains mixed powder
Material, adds in above-mentioned mixing liquid material by mixed powder, stirs 20 ~ 25min with 1200 ~ 1500r/min in vacuum Manufacturing medicine extract machine, closes
Closing high-speed stirred, vacuum scrapes wall stirring degassing 5 ~ 8min, discharging fill, obtains anticaries and repairs dental caries toothpaste；
(5) 0.5 ~ 0.8g sodium bicarbonate, 0.3 ~ 0.5g tri-hypophosphite monohydrate hydrogen dipotassium, 0.1 ~ 0.2g calcium chloride, 0.8 ~ 1.2g are weighed
Sodium chloride, adding 100 ~ 120mL mass fraction is in 5% ethanol solution, under 35 ~ 38 DEG C of waters bath with thermostatic control, with 200 ~ 300r/min
After being uniformly mixed, add 0.12 ~ 0.15g trishydroxymethylaminomethane, and with mass fraction be 5% salt acid for adjusting pH be 7.2
~ 7.3, add 1 ~ 2g Mint Essence, continue stirring 5 ~ 10min, obtain anticaries and repair dental caries collutory.
The application process of the present invention is: when every day sooner or later brushes teeth, and uses anticaries and reparation prepared by 1 ~ 2g present invention
Dental caries toothpaste and collutory, can effectively reduce dental caries incidence rate 80 ~ 90%, and repair both carious surfaces 85 ~ 95% dentium nitor after one month
Matter, effectively fills up the tiny pit-hole of both carious surfaces.
The method have the benefit that:
(1) anticaries prepared by the present invention and repair dental caries toothpaste and collutory, can the generation of effective anticaries, and repairing
Both carious surfaces adamantine layer also fills up said minuscule hole；
(2) anticaries of the present invention and reparation dental caries method are simple, safe and convenient to use.
Detailed description of the invention
Weigh 36 ~ 37g sodium silicate respectively, 11 ~ 12g sodium sulfate, add in 950 ~ 1000mL deionized water, with 200 ~
300r/min stirs 15 ~ 20min, obtains mixed liquor, and mixed liquor is warming up to 80 ~ 85 DEG C, and is 12% sulfuric acid solution with mass fraction
Regulation mixed liquor pH value is 2.5 ~ 3.5, keeps temperature continuously stirred 60 ~ 90min, after standing 30 ~ 40min, proceeds to centrifuge
In, with 5000 ~ 6000r/min centrifugation, collect precipitation, being washed with deionized and being precipitated to cleaning mixture is neutrality, will precipitation
It is placed in drying baker, is dried at 105 ~ 110 DEG C to constant weight, dried product is loaded in ball mill, with 300 ~ 400r/
Min ball milling 1 ~ 2h, obtains toothpaste abrasives silicon dioxide；Weigh 20 ~ 25g Radix Angelicae Dahuricae dry root, 20 ~ 25g Radix Ampelopsis dried pieces respectively
Root, 20 ~ 25g Rhizoma Cyperi dry rhizome, 20 ~ 25g Herba Asari dry rhizome, 20 ~ 25g Rhizoma Chuanxiong dry root, add in pulverizer and pulverize, mistake
200 mesh sieves, the powder after sieving adds in ball mill, with 200 ~ 300r/min ball milling 1 ~ 2h, after ball milling is uniform, obtains Chinese medicines
Powder；Weigh 10 ~ 12g stevioside, 1 ~ 2g Mint Essence, 0.5 ~ 0.8g potassium sorbate, 0.03 ~ 0.05g dopamine hydrochloride, add
In 18 ~ 20mL deionized water, after being uniformly mixed with 300 ~ 400r/min, mix addition vacuum cream with 15 ~ 20g sorbitol
In machine, stir 3 ~ 5min with 500 ~ 600r/min, obtain mixing liquid material；Weigh 40 ~ 45g above-mentioned toothpaste abrasives silicon dioxide, 1
~ 2g cocamido propyl betaine, 1 ~ 2g xanthan gum, the above-mentioned Chinese medicinal powder of 5 ~ 6g, add in food blender, mix homogeneously obtains
Mixed powder, adds in above-mentioned mixing liquid material by mixed powder, in vacuum Manufacturing medicine extract machine with 1200 ~ 1500r/min stirring 20 ~
25min, closing high-speed stirs, and vacuum scrapes wall stirring degassing 5 ~ 8min, discharging fill, obtains anticaries and repairs dental caries toothpaste；
Weigh 0.5 ~ 0.8g sodium bicarbonate, 0.3 ~ 0.5g tri-hypophosphite monohydrate hydrogen dipotassium, 0.1 ~ 0.2g calcium chloride, 0.8 ~ 1.2g sodium chloride,
Adding 100 ~ 120mL mass fraction is in 5% ethanol solution, under 35 ~ 38 DEG C of waters bath with thermostatic control, mixed with 200 ~ 300r/min stirring
After closing uniformly, add 0.12 ~ 0.15g trishydroxymethylaminomethane, and with mass fraction be 5% salt acid for adjusting pH be 7.2 ~ 7.3,
Add 1 ~ 2g Mint Essence, continue stirring 5 ~ 10min, obtain anticaries and repair dental caries collutory.
Example 1
Weigh 36g sodium silicate, 11g sodium sulfate respectively, add in 950mL deionized water, stir 15min with 200r/min, obtain mixed
Close liquid, mixed liquor is warming up to 80 DEG C, and with mass fraction be 12% sulfuric acid solution regulation mixed liquor pH value be 2.5, keep temperature
And continuously stirred 60min, after standing 30min, proceed in centrifuge, with 5000r/min centrifugation, collect precipitation, spend from
It is neutrality that the washing of sub-water is precipitated to cleaning mixture, precipitation is placed in drying baker, is dried to constant weight, by dried at 105 DEG C
Product loads in ball mill, with 300r/min ball milling 1h, obtains toothpaste abrasives silicon dioxide；Weigh the 20g Radix Angelicae Dahuricae respectively to be dried
Root, 20g Radix Ampelopsis dried root, 20g Rhizoma Cyperi dry rhizome, 20g Herba Asari dry rhizome, 20g Rhizoma Chuanxiong dry root, add in pulverizer
Pulverizing, cross 200 mesh sieves, the powder after sieving adds in ball mill, with 200r/min ball milling 1h, after ball milling is uniform, obtains Chinese medicine
Medicated powder；Weigh 10g stevioside, 1g Mint Essence, 0.5g potassium sorbate, 0.03g dopamine hydrochloride, add 18mL deionized water
In, after being uniformly mixed with 300r/min, mix with 15g sorbitol in addition vacuum Manufacturing medicine extract machine, stir with 500r/min
3min, obtains mixing liquid material；Weigh 40g above-mentioned toothpaste abrasives silicon dioxide, 1g cocamido propyl betaine, 1g xanthan
Glue, the above-mentioned Chinese medicinal powder of 5g, add in food blender, mix homogeneously obtains mixed powder, and mixed powder adds above-mentioned mixing
In liquid material, stirring 20min with 1200r/min in vacuum Manufacturing medicine extract machine, closing high-speed stirs, and vacuum scrapes wall stirring degassing 5min,
Discharging fill, obtains anticaries and repairs dental caries toothpaste；Weigh 0.5g sodium bicarbonate, 0.3g tri-hypophosphite monohydrate hydrogen dipotassium, 0.1g
Calcium chloride, 0.8g sodium chloride, adding 100mL mass fraction is in 5% ethanol solution, under 35 DEG C of waters bath with thermostatic control, with 200r/min
After being uniformly mixed, add 0.12g trishydroxymethylaminomethane, and with mass fraction be 5% salt acid for adjusting pH be 7.2, add
1g Mint Essence, continues stirring 5min, obtains anticaries and repairs dental caries collutory.
The application process of the present invention is: when every day brushes teeth sooner or later, anticaries prepared by the use 1g present invention and reparation dental caries
Teeth cream and collutory, can effectively reduce dental caries incidence rate 80%, and repair both carious surfaces 85% enamel, effectively fill out after one month
Mend the tiny pit-hole of both carious surfaces.
Example 2
Weigh 36.5g sodium silicate, 11.5g sodium sulfate respectively, add in 980mL deionized water, stir 18min with 250r/min,
Mixed liquor, mixed liquor is warming up to 82 DEG C, and with mass fraction be 12% sulfuric acid solution regulation mixed liquor pH value be 3.0, keep
Temperature continuously stirred 80min, after standing 35min, proceed in centrifuge, with 5500r/min centrifugation, collects precipitation, uses
It is neutrality that deionized water wash is precipitated to cleaning mixture, precipitation is placed in drying baker, is dried to constant weight at 108 DEG C, will be dried
After product load in ball mill, with 350r/min ball milling 1.5h, obtain toothpaste abrasives silicon dioxide；Weigh 22g respectively white
Root of Dahurian angelica dry root, 22g Radix Ampelopsis dried root, 22g Rhizoma Cyperi dry rhizome, 22g Herba Asari dry rhizome, 22g Rhizoma Chuanxiong dry root, add powder
Pulverizing in broken machine, cross 200 mesh sieves, the powder after sieving adds in ball mill, and with 250r/min ball milling 1.5h, ball milling is uniform
After, obtain Chinese medicinal powder；Weigh 11g stevioside, 1.5g Mint Essence, 0.8g potassium sorbate, 0.04g dopamine hydrochloride, add
In 19mL deionized water, after being uniformly mixed with 350r/min, mix in addition vacuum Manufacturing medicine extract machine with 18g sorbitol, with
550r/min stirs 4min, obtains mixing liquid material；Weigh 42g above-mentioned toothpaste abrasives silicon dioxide, 1.5g cocamidopropyl propyl amide
Glycine betaine, 1.5g xanthan gum, the above-mentioned Chinese medicinal powder of 5.5g, add in food blender, mix homogeneously obtains mixed powder, will mixing
Powder adds in above-mentioned mixing liquid material, stirs 22min with 1300r/min in vacuum Manufacturing medicine extract machine, and closing high-speed stirs, and vacuum is scraped
Wall stirring degassing 7min, discharging fill, obtain anticaries and repair dental caries toothpaste；Weighing 0.7g sodium bicarbonate, 0.4g tri-is hydrated
Dipotassium hydrogen phosphate, 0.15g calcium chloride, 1.0g sodium chloride, adding 110mL mass fraction is in 5% ethanol solution, at 36 DEG C of constant temperature
Under water-bath, after being uniformly mixed with 250r/min, add 0.14g trishydroxymethylaminomethane, and be 5% salt with mass fraction
Acid for adjusting pH is 7.2, adds 1.5g Mint Essence, continues stirring 8min, obtains anticaries and repairs dental caries collutory.
The application process of the present invention is: when every day sooner or later brushes teeth, and uses anticaries and reparation prepared by the 1.5g present invention
Dental caries toothpaste and collutory, can effectively reduce dental caries incidence rate 85%, and repair both carious surfaces 90% enamel, effectively after one month
Fill up the tiny pit-hole of both carious surfaces.
Example 3
Weigh 37g sodium silicate, 12g sodium sulfate respectively, add in 1000mL deionized water, stir 20min with 300r/min, obtain mixed
Close liquid, mixed liquor is warming up to 85 DEG C, and with mass fraction be 12% sulfuric acid solution regulation mixed liquor pH value be 3.5, keep temperature
And continuously stirred 90min, after standing 40min, proceed in centrifuge, with 6000r/min centrifugation, collect precipitation, spend from
It is neutrality that the washing of sub-water is precipitated to cleaning mixture, precipitation is placed in drying baker, is dried to constant weight, by dried at 110 DEG C
Product loads in ball mill, with 400r/min ball milling 2h, obtains toothpaste abrasives silicon dioxide；Weigh the 25g Radix Angelicae Dahuricae respectively to be dried
Root, 25g Radix Ampelopsis dried root, 25g Rhizoma Cyperi dry rhizome, 25g Herba Asari dry rhizome, 25g Rhizoma Chuanxiong dry root, add in pulverizer
Pulverizing, cross 200 mesh sieves, the powder after sieving adds in ball mill, with 300r/min ball milling 2h, after ball milling is uniform, obtains Chinese medicine
Medicated powder；Weigh 12g stevioside, 2g Mint Essence, 0.8g potassium sorbate, 0.05g dopamine hydrochloride, add 20mL deionized water
In, after being uniformly mixed with 400r/min, mix with 20g sorbitol in addition vacuum Manufacturing medicine extract machine, stir with 600r/min
5min, obtains mixing liquid material；Weigh 45g above-mentioned toothpaste abrasives silicon dioxide, 2g cocamido propyl betaine, 2g xanthan
Glue, the above-mentioned Chinese medicinal powder of 6g, add in food blender, mix homogeneously obtains mixed powder, and mixed powder adds above-mentioned mixing
In liquid material, stirring 25min with 1500r/min in vacuum Manufacturing medicine extract machine, closing high-speed stirs, and vacuum scrapes wall stirring degassing 8min,
Discharging fill, obtains anticaries and repairs dental caries toothpaste；Weigh 0.8g sodium bicarbonate, 0.5g tri-hypophosphite monohydrate hydrogen dipotassium, 0.2g
Calcium chloride, 1.2g sodium chloride, adding 120mL mass fraction is in 5% ethanol solution, under 38 DEG C of waters bath with thermostatic control, with 300r/min
After being uniformly mixed, add 0.15g trishydroxymethylaminomethane, and with mass fraction be 5% salt acid for adjusting pH be 7.3, add
2g Mint Essence, continues stirring 10min, obtains anticaries and repairs dental caries collutory.
The application process of the present invention is: when every day brushes teeth sooner or later, anticaries prepared by the use 2g present invention and reparation dental caries
Teeth cream and collutory, can effectively reduce dental caries incidence rate 90%, and repair both carious surfaces 95% enamel, effectively fill out after one month
Mend the tiny pit-hole of both carious surfaces.
Claims (1)
1. an anticaries and reparation dental caries toothpaste and the preparation method of collutory, it is characterised in that concrete preparation process is:
(1) 36 ~ 37g sodium silicate is weighed respectively, 11 ~ 12g sodium sulfate, add in 950 ~ 1000mL deionized water, with 200 ~ 300r/
Min stirs 15 ~ 20min, obtains mixed liquor, and mixed liquor is warming up to 80 ~ 85 DEG C, and is 12% sulfuric acid solution regulation with mass fraction
Mixed liquor pH value is 2.5 ~ 3.5, keeps temperature continuously stirred 60 ~ 90min, after standing 30 ~ 40min, proceeds in centrifuge, with
5000 ~ 6000r/min centrifugation, collects precipitation, and being washed with deionized and being precipitated to cleaning mixture is neutrality, precipitation is placed in dry
In dry case, it is dried at 105 ~ 110 DEG C to constant weight, dried product is loaded in ball mill, with 300 ~ 400r/min ball milling 1
~ 2h, obtains toothpaste abrasives silicon dioxide, standby；
(2) 20 ~ 25g Radix Angelicae Dahuricae dry root, 20 ~ 25g Radix Ampelopsis dried root, 20 ~ 25g Rhizoma Cyperi dry rhizome, 20 ~ 25g are weighed respectively
Herba Asari dry rhizome, 20 ~ 25g Rhizoma Chuanxiong dry root, add in pulverizer and pulverize, and crosses 200 mesh sieves, and the powder after sieving adds goal
In grinding machine, with 200 ~ 300r/min ball milling 1 ~ 2h, after ball milling is uniform, obtain Chinese medicinal powder, standby；
(3) 10 ~ 12g stevioside is weighed, 1 ~ 2g Mint Essence, 0.5 ~ 0.8g potassium sorbate, 0.03 ~ 0.05g dopamine hydrochloride,
Add in 18 ~ 20mL deionized water, after being uniformly mixed with 300 ~ 400r/min, mix addition vacuum with 15 ~ 20g sorbitol
In Manufacturing medicine extract machine, stir 3 ~ 5min with 500 ~ 600r/min, obtain mixing liquid material；
(4) toothpaste abrasives silicon dioxide prepared by 40 ~ 45g above-mentioned steps (1), 1 ~ 2g cocamidopropyl propyl amide Radix Betae are weighed
Alkali, 1 ~ 2g xanthan gum, Chinese medicinal powder prepared by 5 ~ 6g above-mentioned steps (2), add in food blender, mix homogeneously obtains mixed powder
Material, adds in above-mentioned mixing liquid material by mixed powder, stirs 20 ~ 25min with 1200 ~ 1500r/min in vacuum Manufacturing medicine extract machine, closes
Closing high-speed stirred, vacuum scrapes wall stirring degassing 5 ~ 8min, discharging fill, obtains anticaries and repairs dental caries toothpaste；
(5) 0.5 ~ 0.8g sodium bicarbonate, 0.3 ~ 0.5g tri-hypophosphite monohydrate hydrogen dipotassium, 0.1 ~ 0.2g calcium chloride, 0.8 ~ 1.2g are weighed
Sodium chloride, adding 100 ~ 120mL mass fraction is in 5% ethanol solution, under 35 ~ 38 DEG C of waters bath with thermostatic control, with 200 ~ 300r/min
After being uniformly mixed, add 0.12 ~ 0.15g trishydroxymethylaminomethane, and with mass fraction be 5% salt acid for adjusting pH be 7.2
~ 7.3, add 1 ~ 2g Mint Essence, continue stirring 5 ~ 10min, obtain anticaries and repair dental caries collutory.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610646479.5A CN106176378A (en) | 2016-08-09 | 2016-08-09 | A kind of anticaries and reparation dental caries toothpaste and the preparation method of collutory |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610646479.5A CN106176378A (en) | 2016-08-09 | 2016-08-09 | A kind of anticaries and reparation dental caries toothpaste and the preparation method of collutory |
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| CN106176378A true CN106176378A (en) | 2016-12-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362052A (en) * | 2017-06-30 | 2017-11-21 | 常州思宇知识产权运营有限公司 | A kind of sensitive teeth dentinal tubule sealer and preparation method thereof |
| CN110559211A (en) * | 2019-10-10 | 2019-12-13 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition and preparation method and application thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
-
2016
- 2016-08-09 CN CN201610646479.5A patent/CN106176378A/en active Pending
Non-Patent Citations (2)
| Title |
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| 中华人民共和国国家质量监督检验检疫总局，中国国家标准化管理委员会: "《牙膏中禁用组分》", 《中华人民共和国国家标准GB22115-2008，牙膏用原料规范》 * |
| 国家中医药管理局中华本草编委会: "《中华本草》", 31 December 1999, 上海科学技术出版 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362052A (en) * | 2017-06-30 | 2017-11-21 | 常州思宇知识产权运营有限公司 | A kind of sensitive teeth dentinal tubule sealer and preparation method thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110559211A (en) * | 2019-10-10 | 2019-12-13 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition and preparation method and application thereof |
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