CN106176331A - A kind of have antioxidation, defying age, the prescription of whitening effect, cosmetics and preparation method thereof - Google Patents
A kind of have antioxidation, defying age, the prescription of whitening effect, cosmetics and preparation method thereof Download PDFInfo
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- CN106176331A CN106176331A CN201510226188.6A CN201510226188A CN106176331A CN 106176331 A CN106176331 A CN 106176331A CN 201510226188 A CN201510226188 A CN 201510226188A CN 106176331 A CN106176331 A CN 106176331A
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Abstract
The invention discloses a cosmetics TE-cell prescription with antioxidation, defying age, whitening effect, TE-cell prescription contains Ramulus et Folium Mussaendae Pubescentis cell extract, edelweiss extract.The cell membrane of Ramulus et Folium Mussaendae Pubescentis cell extract is double immobilized artificial membranes, is also semipermeable membrane, therefore can a part of material of selective absorbing；It addition, utilize physical concentration pressure principle, making in the solution of Ramulus et Folium Mussaendae Pubescentis cell medium outside, when the concentration of edelweiss extract is higher than the intracellular density of Ramulus et Folium Mussaendae Pubescentis, edelweiss extract can be entered in Ramulus et Folium Mussaendae Pubescentis cell membrane by semipermeable membrane；Compared with the product simply using independent tea extract and edelweiss extract, double immobilized artificial membranes that the cell membrane of Ramulus et Folium Mussaendae Pubescentis cell has can penetrate into skin easily, can carry inside the edelweiss extract entrance skin that cell absorbs simultaneously；It addition, the polyphenol substance of edelweiss extract and being oxidized easily, by the protection of double immobilized artificial membranes, reduce the oxidizing process of polyphenol substance, such that it is able to keep effect of edelweiss extract.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of there is antioxidation, defying age, the prescription of whitening effect, cosmetics and preparation method thereof.
Background technology.
Due to socioeconomic development, environmental pollution is relatively big, and ozone hole expands, and skin is the most all exposed in ultraviolet and environmental pollution, and if things go on like this skin can be the most aging and various mottle occur, and the health of skin can be brought unfavorable factor.Prove through modern scientific research, the result that skin aging causes with occurring mottle to be irradiated with mainly due to not protected skin.And there is the problem that effect is indefinite and certain untoward reaction occurs in the facial cosmetics great majority used at present.
Along with growth in the living standard and human sciences's accumulation of knowledge, people have a very large change for the requirement of facial cosmetics.
The most conventional facial product effect is not ideal enough.So people be highly desirable to have definite effect, effect by way of various, safely, a cosmetic product with antioxidation, defying age, whitening effect that has no adverse reaction.
Summary of the invention
Embodiment of the present invention technical problem to be solved is, it is provided that a kind of prescription with antioxidation, defying age, whitening effect.
The described prescription with antioxidation, defying age, whitening effect, it is characterised in that include tea extract and edelweiss extract.
Including 1-75% tea extract and 1-75% edelweiss extract.
The embodiment of the present invention additionally provides the cosmetics of a kind of prescription with antioxidation, defying age, whitening effect.
nullDescribed has antioxidation、Defying age、The cosmetics of the prescription of whitening effect，It is characterized in that: include following composition by weight percentage: glycerol 1～15%、Propylene glycol 1～15%、Caprylic/capric triglyceride 1～10%、Cyclomethicone 1～5%、Jojoba seed oil 1～5%、Cetearyl alcohol 0.1～5%、Glycerol caprylate 0.1～5%、Fructus oleae europaeae fruit oil 0.1～5%、Butyrospermum parkii fruit fat 0.1～5%、Glyceryl stearate 0.1～5%、PEG-60 Semen Armeniacae Amarum glyceride type 0.1～5%、Tea extract and edelweiss extract formula 0.5～2.5%、Cer EOS 0.1～0.5%、Hyaluronic acid 0.1～0.5%、Tranamic acid 0.1～0.5%、Triethanolamine 0.1～0.2%、Sensiva SC50 0.1～0.5%、Methylisothiazolinone 0.005%，Remaining for water.
The embodiment of the present invention additionally provides the preparation method of the cosmetics of a kind of prescription having antioxidation, defying age, whitening effect, comprises the steps:
(1) water, glycerol, propylene glycol, hyaluronic acid, tranamic acid addition aqueous phase agitated kettle will be heated to 80 DEG C of sterilizings half an hour；
(2) caprylic/capric triglyceride, Cyclomethicone, Jojoba seed oil, cetearyl alcohol, glycerol caprylate, Fructus oleae europaeae fruit oil, Butyrospermum parkii fruit fat, glyceryl stearate, PEG-60 Semen Armeniacae Amarum glyceride type are added oil phase agitated kettle and be heated to 80 DEG C；
(3) open stirring 60 revs/min, aqueous phase, oil phase raw material are pumped into vacuum stirring pot, homogenizing 10 minutes；
(4) vacuum outgas 20 minutes；
(5) mixing speed is down to 30 revs/min, stirring cooling；
(6) when temperature is down to 35 DEG C, add tea extract and edelweiss extract formula, Cer EOS triethanolamine, Sensiva SC50 and Methylisothiazolinone stir；
(7) discharging, stands, after the assay was approved, and fill, packaging, coding；
(8) after the assay was approved, warehouse-in.
Implement the embodiment of the present invention, have the advantages that
A cosmetics with antioxidation, defying age, whitening effect of the embodiment of the present invention, TE-cell prescription contains Ramulus et Folium Mussaendae Pubescentis cell extract, edelweiss extract.The cell membrane of Ramulus et Folium Mussaendae Pubescentis cell extract is double immobilized artificial membranes, is also semipermeable membrane, therefore can a part of material of selective absorbing.It addition, utilize physical concentration pressure principle, making in the solution of Ramulus et Folium Mussaendae Pubescentis cell medium outside, when the concentration of edelweiss extract is higher than the intracellular density of Ramulus et Folium Mussaendae Pubescentis, edelweiss extract can be entered in Ramulus et Folium Mussaendae Pubescentis cell membrane by semipermeable membrane；Compared with the product simply using independent tea extract and edelweiss extract, double immobilized artificial membranes that the cell membrane of Ramulus et Folium Mussaendae Pubescentis cell has can penetrate into skin easily, can carry inside the edelweiss extract entrance skin that cell absorbs simultaneously.
It addition, there is the polyphenol substance of the edelweiss extract of high-efficiency antioxidant, white-skinned face function and be oxidized easily, by the protection of double immobilized artificial membranes, reduce the oxidizing process of polyphenol substance, such that it is able to keep effect of edelweiss extract.Thoroughly compensate for the open defect of commercially available prod function singleness, owing to this composition is combined as water solublity, so not limited by product forms, face cleaning, water preparation, emulsion, cream, elite, BB frost and sunscreen product etc. can be made an addition to.
Accompanying drawing explanation
Fig. 1 is the gene expression test schematic diagram of embodiment of the present invention epidermal melanocytes (NHEM).
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below the present invention is described in further detail.
Tea (CAMELLIA SINENSIS) extract (Ramulus et Folium Mussaendae Pubescentis cell extract) of the embodiment of the present invention present invention, edelweiss (LEONTOPODIUM ALPINUM) extract (edelweiss extract) prescription TE-cell can be used for preparing a cosmetics with antioxidation, defying age, whitening effect；
The formula of the cosmetics with antioxidation, defying age, whitening effect is as follows:
Production technology:
1, Jiang Shui, glycerol, propylene glycol, hyaluronic acid, tranamic acid addition aqueous phase agitated kettle are heated to 80 DEG C of sterilizings half an hour.
2, caprylic/capric triglyceride, Cyclomethicone, Jojoba (SIMMONDSIA CHINENSIS) seed oil, cetearyl alcohol, glycerol caprylate, Fructus oleae europaeae (OLEA EUROPAEA) fruit oil, Butyrospermum parkii (BUTYROSPERMUM PARKII) really fat, glyceryl stearate, PEG-60 Semen Armeniacae Amarum glyceride type are added oil phase agitated kettle and be heated to 80 DEG C.
3, open stirring 60 revs/min, aqueous phase, oil phase raw material are pumped into vacuum stirring pot, homogenizing 10 minutes.
4, vacuum outgas 20 minutes；
5, mixing speed is down to 30 revs/min, stirring cooling.
6, when temperature is down to 35 DEG C, plant extract prescription TE-cell, Cer EOS and remaining raw material stirring are added uniform.
7, discharging, stands, after the assay was approved, and fill, packaging, coding.
8, after the assay was approved, warehouse-in.
TE-cell prescription " Ramulus et Folium Mussaendae Pubescentis cell extract, edelweiss extract " promotes cellular matrix, the test report promoting the gene expression of cell proliferation and suppression egg white injury, epidermal melanocytes (NHEM) to test for cell.
Illustrate:
Prescription used in the most following test is the cosmetics prescription with antioxidation, defying age, white-skinned face function of the present invention；
2. Dan Baiduotang proteoglycan PG, elastin laminin, collagen protein, glycosaminoglycans, the test of extracting and analyze of KI67 are used for observing the facilitation of medicine cell proliferation；
3.MMP3 extracts and analyzes test for observing the medicine inhibitory action to Protein Damage；
Test plan:
Material: using and test containing Ramulus et Folium Mussaendae Pubescentis cell extract, the cosmetics of edelweiss extract TE-cell prescription, wherein, the addition of TE-cell is respectively 0.5%, 1%, 2.5%.
One, cellular matrix concentration promotes to test:
1. Dan Baiduotang proteoglycan PG
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, the Dan Baiduotang proteoglycan PG ratio around cell membrane rises 19%, 28% and 35% respectively.
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, the Dan Baiduotang proteoglycan PG ratio of cross-film rises 20%, 25% and 33% respectively.
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, the Dan Baiduotang proteoglycan PG ratio of substrate rises 23%, 29% and 26% respectively.
2. elastin laminin
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, elastin laminin ratio rises 20%, 28% and 32% respectively.
3. collagen protein
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, collagen protein ratio rises 22%, 28% and 31% respectively.
4. glycosaminoglycans
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, glycosaminoglycans ratio rises 20%, 29% and 37% respectively.
Two, cell proliferation promotes to test:
When the addition of TE-cell prescription is respectively 0.5%, 1% and 2.5%, keratinocyte proliferation quantity rises 16%, 20% and 24% respectively.
Three, Protein Damage inhibition test:
When the addition of TE-cell prescription is respectively 0.5%, 1%, 2.5%, MMP3 concentration have dropped 18%, 26% and 32% respectively.
Four, the gene expression test of epidermal melanocytes (NHEM)
After the edelweiss extract of application 0.1mg/ml is cultivated 72 hours, and blank has significantly difference.Can be seen that from chart, this composition can affect melanic synthesis (TYR, DCT), melanin generates (MC1R, PCSK2 and POMC), the transhipment (MLPH) of melanosome, interaction (the NOV of melanocyte-keratinocyte, CTNNA1, F2TL1, EDN1, EDNRB), epidermal growth factor (EFG, EGRF, HBEGF) and inflammation (CSF1).
Four, conclusion
This test (1) detects cellular matrix concentration by detection Dan Baiduotang proteoglycan PG, glycosaminoglycans, collagen protein, the concentration of elastin laminin, therefore, Dan Baiduotang proteoglycan PG, glycosaminoglycans, collagen protein, elastin laminin concentration the highest, show that cellular matrix concentration is the highest.(2) cel l proliferation is detected by the concentration of detection KI67.Because KI67 is primarily used for judging the proliferation activity index of cell, therefore, KI67 concentration is the highest, shows that cel l proliferation is the most active.(3) being detected the degree of injury of protein by the concentration of detection MMP3, and the biological function of MMP3 is mainly degradation of cell extracellular matrix protein, therefore, MMP3 concentration is the lowest, shows that the Degradation of protein is the lowest, damages the fewest.(4) being shown by the gene expression test of human epidermal melanocyte (NHEM), this composition can affect melanic synthesis (TYR, DCT), melanin generates (MC1R, PCSK2 and POMC), the transhipment (MLPH) of melanosome, interaction (the NOV of melanocyte-keratinocyte, CTNNA1, F2TL1, EDN1, EDNRB), epidermal growth factor (EFG, EGRF, HBEGF) and inflammation (CSF1).
As can be seen here, a have antioxidation, defying age, the cosmetics prescription of white-skinned face function have and higher promote cell proliferation, promote cellular matrix concentration, suppress Protein Damage, the ability preventing melanocyte from generating.
Above disclosed it is only one preferred embodiment of the present invention, certainly can not limit the interest field of the present invention, the equivalent variations therefore made according to the claims in the present invention with this, still belong to the scope that the present invention is contained.
Claims (4)
1. a prescription with antioxidation, defying age, whitening effect, it is characterised in that include tea extract and edelweiss extract.
There is the prescription of antioxidation, defying age, whitening effect the most as claimed in claim 1, it is characterised in that include 1-75% tea extract and 1-75% edelweiss extract.
null3. one kind containing having antioxidation as claimed in claim 1、Defying age、The cosmetics of the prescription of whitening effect，It is characterized in that: include following composition by weight percentage: glycerol 1～15%、Propylene glycol 1～15%、Caprylic/capric triglyceride 1～10%、Cyclomethicone 1～5%、Jojoba seed oil 1～5%、Cetearyl alcohol 0.1～5%、Glycerol caprylate 0.1～5%、Fructus oleae europaeae fruit oil 0.1～5%、Butyrospermum parkii fruit fat 0.1～5%、Glyceryl stearate 0.1～5%、PEG-60 Semen Armeniacae Amarum glyceride type 0.1～5%、Tea extract and edelweiss extract formula 0.5～2.5%、Cer EOS 0.1～0.5%、Hyaluronic acid 0.1～0.5%、Tranamic acid 0.1～0.5%、Triethanolamine 0.1～0.2%、Sensiva SC50 0.1～0.5%、Methylisothiazolinone 0.005%，Remaining for water.
4. the preparation method of the cosmetics of a prescription as claimed in claim 3 with antioxidation, defying age, whitening effect, it is characterised in that comprise the steps:
(1) water, glycerol, propylene glycol, hyaluronic acid, tranamic acid addition aqueous phase agitated kettle will be heated to 80 DEG C of sterilizings half an hour;
(2) by caprylic/capric triglyceride, Cyclomethicone, Jojoba seed oil,
Cetearyl alcohol, glycerol caprylate, Fructus oleae europaeae fruit oil, Butyrospermum parkii fruit fat, glyceryl stearate, PEG-60 Semen Armeniacae Amarum glyceride type add oil phase agitated kettle and are heated to 80 DEG C;
(3) open stirring 60 revs/min, aqueous phase, oil phase raw material are pumped into vacuum stirring pot, homogenizing 10 minutes;
(4) vacuum outgas 20 minutes；
(5) mixing speed is down to 30 revs/min, stirring cooling;
(6) when temperature is down to 35 DEG C, add tea extract and edelweiss extract formula, Cer EOS, triethanolamine, Sensiva SC50 and Methylisothiazolinone stir;
(7) discharging, stands, after the assay was approved, and fill, packaging, coding;
(8) after the assay was approved, warehouse-in.
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| CN201510226188.6A CN106176331A (en) | 2015-05-04 | 2015-05-04 | A kind of have antioxidation, defying age, the prescription of whitening effect, cosmetics and preparation method thereof |
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| CN201510226188.6A CN106176331A (en) | 2015-05-04 | 2015-05-04 | A kind of have antioxidation, defying age, the prescription of whitening effect, cosmetics and preparation method thereof |
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Address after: Yuncheng West Road, Baiyun District of Guangzhou City, Guangdong province 510000 No. 888 room 3007 Applicant after: HANHOO COSMETICS CO.,LTD. Address before: Yuncheng West Road, Baiyun District of Guangzhou City, Guangdong province 510000 No. 888 room 908 Applicant before: HANHOO COSMETICS CO.,LTD. Address after: Yuncheng West Road, Baiyun District of Guangzhou City, Guangdong province 510000 No. 888 room 908 Applicant after: HANHOO COSMETICS CO.,LTD. Address before: 11, building 17, 510000 Guangdong province Guangzhou Guangsheng International Building Tianhe District Zhujiang New City, Jiangxi Road Applicant before: GUANGZHOU SHICHANGSHENG COSMETICS CO.,LTD. |
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Application publication date: 20161207 |