CN106164286A - 用于检测的方法和系统 - Google Patents

用于检测的方法和系统 Download PDF

Info

Publication number
CN106164286A
CN106164286A CN201480070346.7A CN201480070346A CN106164286A CN 106164286 A CN106164286 A CN 106164286A CN 201480070346 A CN201480070346 A CN 201480070346A CN 106164286 A CN106164286 A CN 106164286A
Authority
CN
China
Prior art keywords
chamber
detection
cells
sample
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480070346.7A
Other languages
English (en)
Chinese (zh)
Inventor
费尔南多·帕托洛斯基
乐昶·熊
瓦迪姆·卡利夫斯基
弗拉基米尔·那达喀尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lamott Tel Aviv University Co Ltd
Original Assignee
Lamott Tel Aviv University Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lamott Tel Aviv University Co Ltd filed Critical Lamott Tel Aviv University Co Ltd
Publication of CN106164286A publication Critical patent/CN106164286A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7057—(Intracellular) signaling and trafficking pathways
    • G01N2800/7066—Metabolic pathways

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Electrochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
CN201480070346.7A 2013-10-22 2014-10-22 用于检测的方法和系统 Pending CN106164286A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361893977P 2013-10-22 2013-10-22
US61/893,977 2013-10-22
PCT/IL2014/050921 WO2015059704A1 (en) 2013-10-22 2014-10-22 Method and system for sensing

Publications (1)

Publication Number Publication Date
CN106164286A true CN106164286A (zh) 2016-11-23

Family

ID=51894171

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480070346.7A Pending CN106164286A (zh) 2013-10-22 2014-10-22 用于检测的方法和系统

Country Status (11)

Country Link
US (2) US10274456B2 (enExample)
EP (1) EP3060675B1 (enExample)
JP (1) JP6609247B2 (enExample)
KR (1) KR20160072258A (enExample)
CN (1) CN106164286A (enExample)
AU (1) AU2014338510A1 (enExample)
CA (1) CA2927332A1 (enExample)
HK (1) HK1225414B (enExample)
MX (1) MX2016005273A (enExample)
SG (1) SG11201602976XA (enExample)
WO (1) WO2015059704A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109863397A (zh) * 2016-08-22 2019-06-07 拉莫特特拉维夫大学有限公司 用于检测生物分析物的方法及系统
CN110038652A (zh) * 2014-09-11 2019-07-23 克忧健康公司 用于检测和量化分析物的系统和方法
CN111133312A (zh) * 2017-08-21 2020-05-08 萨维塞尔诊断有限公司 诊断和治疗肺癌的方法
CN111458392A (zh) * 2019-01-18 2020-07-28 财团法人交大思源基金会 用来侦测全细胞细菌的以场效晶体管为主的生物感测器以及包含生物感测器的生物感测器组
CN111487107A (zh) * 2020-06-07 2020-08-04 黑龙江省农业科学院农产品质量安全研究所 一种用于食品安全检测的样本分级处理装置
TWI852718B (zh) * 2023-08-08 2024-08-11 國立清華大學 多病毒檢測裝置、系統及其使用方法
US12201452B2 (en) 2016-08-22 2025-01-21 Ramot At Tel-Aviv University Ltd. Method and system for subcutaneous sensing

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10274456B2 (en) 2013-10-22 2019-04-30 Ramot At Tel-Aviv University Ltd. Method and system for sensing
RU2018124339A (ru) 2015-12-09 2020-01-09 Рамот Ат Тель-Авив Юниверсити Лтд. Способ и система для сенсорного обнаружения посредством модифицированной наноструктуры
US10940474B2 (en) * 2016-03-21 2021-03-09 University Of South Australia Oxidant sensor
AU2017276539B2 (en) * 2016-06-10 2019-06-27 Unilever Global Ip Limited A machine comprising a device for controlling the machine or process by detecting a quality of a fluid formulation to be introduced in the machine and corresponding methods
US11193888B2 (en) 2017-03-29 2021-12-07 Ramot At Tel-Aviv University Ltd. Method and system for separating biomolecules from a mixture containing same
WO2018198008A1 (en) * 2017-04-24 2018-11-01 Abdolahad Mohammad In-situ microbubbles generation for ultrasonic biomedical applications
CN109642885A (zh) 2017-06-15 2019-04-16 拉莫特特拉维夫大学有限公司 含过氧化物化合物的电化学检测
SG11201911855PA (en) 2017-06-15 2020-01-30 Univ Ramot Electrochemical detection of nitro-containing compounds
US11179077B2 (en) 2017-06-20 2021-11-23 Mohammad Abdolahad Apparatus for in-vivo measuring of H2O2 oxidation
US10786188B1 (en) * 2017-06-20 2020-09-29 Mohammad Abdolahad Real-time and label free analyzer for in-vitro and in-vivo detection of cancer
CN111225604A (zh) * 2017-06-20 2020-06-02 穆罕默德.阿波拉哈德 用于对癌症可疑区域进行体外和体内检测的实时无标记分析仪
RU2740358C1 (ru) * 2017-08-01 2021-01-13 Иллюмина, Инк. Полевые датчики
JP7455187B2 (ja) 2019-07-12 2024-03-25 キューラブ・メディカル・リミテッド 電気化学ｆｅｔセンサ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005004204A2 (en) * 2003-06-24 2005-01-13 California Institute Of Technology An electrochemical method and resulting structures for attaching molecular and biomolecular structures to semiconductor micro and nanostructures
WO2008030395A1 (en) * 2006-09-07 2008-03-13 California Institute Of Technology Apparatus and method for quantitative determination of target molecules
WO2009104180A1 (en) * 2008-02-18 2009-08-27 Technion Research And Development Foundation Ltd. Nitrogen oxide sensitive field effect transistors for explosive detection comprising functionalized non-oxidized silicon nanowires

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2214442C3 (de) * 1972-03-24 1981-09-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Überführung von Glucose in Gluconsäure
EP1342075B1 (en) 2000-12-11 2008-09-10 President And Fellows Of Harvard College Device contaning nanosensors for detecting an analyte and its method of manufacture
WO2004034025A2 (en) 2002-10-10 2004-04-22 Nanosys, Inc. Nano-chem-fet based biosensors
WO2008027078A2 (en) 2006-03-15 2008-03-06 President And Fellows Of Harvard College Nanobioelectronics
US20100093019A1 (en) * 2007-01-12 2010-04-15 Environmental Biotechnology Crc Pty Limited Sample handling device
US20110210309A1 (en) 2008-11-04 2011-09-01 Ramot At Tel-Aviv University Ltd. Tubular nanostructures, processes of preparing same and devices made therefrom
JP2012511156A (ja) 2008-12-05 2012-05-17 ナノアイヴイディー，インコーポレイテッド ポイント・オブ・ケア分析器用マイクロ流体ベースのラボオンテストカード
US20100256344A1 (en) * 2009-04-03 2010-10-07 University Of Southern California Surface modification of nanosensor platforms to increase sensitivity and reproducibility
GB2471470A (en) 2009-06-30 2011-01-05 Hewlett Packard Development Co Quantum repeater and system and method for creating extended entanglements utilising cyclic synchronised control signals at repeater relay nodes
DE102010002915B4 (de) * 2010-03-16 2012-10-18 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Mikrofluidischer Sensor
WO2012082494A2 (en) 2010-12-14 2012-06-21 Morehouse School Of Medicine The use of anti-cxcl13 and anti-cxcr5 antibodies for the treatment or detection of cancer
WO2012137207A1 (en) 2011-04-06 2012-10-11 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
US10274456B2 (en) 2013-10-22 2019-04-30 Ramot At Tel-Aviv University Ltd. Method and system for sensing
RU2018124339A (ru) 2015-12-09 2020-01-09 Рамот Ат Тель-Авив Юниверсити Лтд. Способ и система для сенсорного обнаружения посредством модифицированной наноструктуры

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005004204A2 (en) * 2003-06-24 2005-01-13 California Institute Of Technology An electrochemical method and resulting structures for attaching molecular and biomolecular structures to semiconductor micro and nanostructures
WO2008030395A1 (en) * 2006-09-07 2008-03-13 California Institute Of Technology Apparatus and method for quantitative determination of target molecules
WO2009104180A1 (en) * 2008-02-18 2009-08-27 Technion Research And Development Foundation Ltd. Nitrogen oxide sensitive field effect transistors for explosive detection comprising functionalized non-oxidized silicon nanowires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARPITA DE等: "Integrated label-free silicon nanowire sensor arrays for (bio)chemical analysis", 《ANALYST》 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110038652A (zh) * 2014-09-11 2019-07-23 克忧健康公司 用于检测和量化分析物的系统和方法
CN110038652B (zh) * 2014-09-11 2021-12-07 克忧健康公司 用于检测和量化分析物的系统和方法
CN109863397A (zh) * 2016-08-22 2019-06-07 拉莫特特拉维夫大学有限公司 用于检测生物分析物的方法及系统
US11906463B2 (en) 2016-08-22 2024-02-20 Ramot At Tel-Aviv University Ltd. Methods and systems for detecting bioanalytes
US12201452B2 (en) 2016-08-22 2025-01-21 Ramot At Tel-Aviv University Ltd. Method and system for subcutaneous sensing
CN111133312A (zh) * 2017-08-21 2020-05-08 萨维塞尔诊断有限公司 诊断和治疗肺癌的方法
US12306188B2 (en) 2017-08-21 2025-05-20 Savicell Diagnostic Methods of diagnosing and treating lung cancer
CN111458392A (zh) * 2019-01-18 2020-07-28 财团法人交大思源基金会 用来侦测全细胞细菌的以场效晶体管为主的生物感测器以及包含生物感测器的生物感测器组
CN111487107A (zh) * 2020-06-07 2020-08-04 黑龙江省农业科学院农产品质量安全研究所 一种用于食品安全检测的样本分级处理装置
CN111487107B (zh) * 2020-06-07 2022-12-09 黑龙江省农业科学院农产品质量安全研究所 一种用于食品安全检测的样本分级处理装置
TWI852718B (zh) * 2023-08-08 2024-08-11 國立清華大學 多病毒檢測裝置、系統及其使用方法

Also Published As

Publication number Publication date
US20160258899A1 (en) 2016-09-08
SG11201602976XA (en) 2016-05-30
AU2014338510A1 (en) 2016-06-09
CA2927332A1 (en) 2015-04-30
MX2016005273A (es) 2017-01-05
US20190234900A1 (en) 2019-08-01
HK1225414B (en) 2017-09-08
JP2016535988A (ja) 2016-11-24
US10274456B2 (en) 2019-04-30
KR20160072258A (ko) 2016-06-22
WO2015059704A1 (en) 2015-04-30
JP6609247B2 (ja) 2019-11-20
EP3060675B1 (en) 2019-01-30
EP3060675A1 (en) 2016-08-31

Similar Documents

Publication Publication Date Title
EP3387420B1 (en) Sensing system comprising a nanostructure transistor and corresponding sensing method
JP6609247B2 (ja) 検知のための方法及びシステム
HK1225414A1 (en) Method and system for sensing
Liu et al. Light-responsive metal–organic framework as an oxidase mimic for cellular glutathione detection
Zhang et al. In situ formation of gold nanoparticles decorated Ti3C2 MXenes nanoprobe for highly sensitive electrogenerated chemiluminescence detection of exosomes and their surface proteins
Zhou et al. Ternary electrochemiluminescence nanostructure of Au nanoclusters as a highly efficient signal label for ultrasensitive detection of cancer biomarkers
Jin et al. Electrochemical-signal-amplification strategy for an electrochemiluminescence immunoassay with g-C3N4 as tags
Zheng et al. Ultrasensitive enzyme-free biosensor by coupling cyclodextrin functionalized Au nanoparticles and high-performance Au-paper electrode
Xiao et al. Colorimetric biosensor for detection of cancer biomarker by Au nanoparticle-decorated Bi2Se3 nanosheets
Liu et al. Graphitic carbon nitride nanosheets-based ratiometric fluorescent probe for highly sensitive detection of H2O2 and glucose
Qiao et al. Enhancing the electrochemiluminescence of luminol by chemically modifying the reaction microenvironment
Zhang et al. In situ activation of CdS electrochemiluminescence film and its application in H2S detection
Su et al. Colorimetric analysis of carcinoembryonic antigen using highly catalytic gold nanoparticles-decorated MoS2 nanocomposites
Zhou et al. Thiol stabilized Au nanoclusters with efficient electrochemiluminescence for the simultaneous and ultrasensitive detection of GSH and Cu2+
Ding et al. A hybrid of FeS2 nanoparticles encapsulated by two-dimensional carbon sheets as excellent nanozymes for colorimetric glucose detection
Boruah et al. Porous nitrogen-doped crumpled graphene nanoparticles: a metal-free nanozyme for selective detection of dopamine in aqueous medium and human serum
Dong et al. Bimetallic CoMoO4 nanozymes enhanced luminol chemiluminescence for the detection of dopamine
Liu et al. Highly chemiluminescent graphene oxide hybrids bifunctionalized by N-(aminobutyl)-N-(ethylisoluminol)/horseradish peroxidase and sensitive sensing of hydrogen peroxide
Li et al. Biothiols as chelators for preparation of N-(aminobutyl)-N-(ethylisoluminol)/Cu2+ complexes bifunctionalized gold nanoparticles and sensitive sensing of pyrophosphate ion
Zhou et al. Core–shell heterostructured CuFe@ FeFe Prussian blue analogue coupling with silver nanoclusters via a one-step bioinspired approach: efficiently nonlabeled aptasensor for detection of bleomycin in various aqueous environments
Hu et al. Layer-by-layer self-assembly of MoS2/PDDA hybrid film in microfluidic chips for ultrasensitive electrochemical immunosensing of alpha-fetoprotein
Roushani et al. Two-dimensional mesoporous copper hydroxide nanosheets shelled on hollow nitrogen-doped carbon nanoboxes as a high performance aptasensing platform
Wang et al. Alkaline phosphatase-triggered etching of Au@ FeOOH nanoparticles for enzyme level assay under dark-field microscopy
Sun et al. Ultrasmall Pt nanozymes immobilized on spherical polyelectrolyte brushes with robust peroxidase-like activity for highly sensitive detection of cysteine
Krivitsky et al. Cellular metabolomics by a universal redox-reactive nanosensors array: from the cell level to tumor-on-a-chip analysis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20161123