CN106138744A - A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis - Google Patents
A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, it is specifically related to a kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis, in parts by weight, formulated by following Chinese medicine material: wilson passionflower herb 15～20 parts, cynomorium songaricum 10～15 parts, the fruit of Chinese wolfberry 5～8 parts, eclipta 5～8 parts, semen astragali complanati 5～8 parts, the bighead atractylodes rhizome 5～8 parts, Bai Long wear coloured silk 15～20 parts, latifolious rush rhizome 10～15 parts, 10～15 parts of pocket orchid, hang Huang 5～10 parts, ginseng 3～5 parts, keel 5～10 parts, the red root of herbaceous peony 5～10 parts.It is an advantage of the current invention that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases tonify the liver and kidney with having, and nourish effect of essence and blood, and the liver-kidney Yin deficiency type giant cell arteritis treatment for gerontal patient has the features such as determined curative effect, instant effect, cure rate is high, have no side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis.
Background technology
Giant cell arteritis (giant cell arteritis, GCA) is a kind of with the systematicness based on infringement cranium artery
Vasculitis, mainly affects the elderly, and age of onset peak is 60～80 years old, and the incidence of disease increases with the age and is multiplied, with
Aging population and the increase to this disease cognitive, in recent years, the morbidity of GCA is in rising trend.GCA patient vessel's inflammation is the most normal
Seeing arch of aorta branch vessel, involved vessels is often in segmental or sheet distribution, and it is shallow dynamic that the blood vessel seriously got involved is more common in temporo
Arteries and veins, vertebral artery and ophthalmic artery and eyelash artery, secondly for entocranial artery, the outer artery of cranium and arter centralis retinae, can cause
The clinical manifestations such as temples headache, lower jaw intermittence dyskinesia, visual impairment and cerebral apoplexy.Wherein visual impairment usually can not
Inverse property, 60% patient may result in blind.The therapeutic purpose of GCA is to control inflammation, and improves patients symptomatic, prevents ischemic complications
(such as visual impairment etc.) shows effect.
GCA often invades many places artery, easily causes blind severe complication of Denging, therefore once clarifies a diagnosis and should i.e. give sugar skin
Matter hormone therapy.General advocate with heavy dose of perennial treatment, such as metacortandracin, maintain remission, erythrocyte sedimentation rate drop to normally or
Close to starting decrement when normal, about need the several months total course for the treatment of, should not decrement or disable too early, in order to avoid state of an illness resume combustion.After stable disease
Use daystart single administration instead or to use alternate day therapy instead be desirable effective scheme.
GCA in current treatment means, mainly with glucocorticoid based on, but Long-Time Service glucocorticoid has
A lot of side effects, specific as follows: (1) induces or increases the weight of to infect: glucocorticoid can suppress the immunologic function of body, and nonreactive
Bacterium effect, therefore prolonged application often can induce infection or increase the weight of to infect, and internal latent infection stove can be made to spread or static focus of infection
Resume combustion, is especially original counteragent descender, such as nephrotic syndrome, pulmonary tuberculosis, aplastic amenia people etc..(2) material
Metabolism is with water and salt metabolic disturbance: long-term extensive application glucocorticoid can cause metabolism and water and salt metabolic disturbance, class occurs
The hyperfunction syndrome of adrenal cortex function, as edema, Diagnostic value, hypertension, glycosuria, thinning of skin, moon shaped face, buffalo hump, to
The symptoms such as disposition obesity, crinosity, acne, myasthenia and amyotrophia, are typically not required to especially treat, can disappear voluntarily after drug withdrawal.But
Myasthenia recovers slow and incomplete.Less salt, low sugar, high-protein diet and add and can mitigate these symptoms with measures such as potassium chloride.This
Outward, glucocorticoid is owing to suppressing the synthesis of protein, can delay the wound healing of wounded patient.At children's Ke Yin Developing restraint
The secretion of hormone and cause negative nitrogen balance, making to grow is affected.(3) cardiovascular complications: prolonged application sugar skin
Matter hormone, raises owing to may result in sodium, water retention and blood fat, can induce hypertension and atherosclerotic.(4) digestive system is simultaneously
Sending out disease: Gucocorticoid can stimulate hydrochloric acid in gastric juice, pepsic secretion and suppress gastric mucus secretion, reduces the resistance of gastric mucosa
Power, therefore can induce or aggravate peptic ulcer, glucocorticoid also can cover up the initial symptoms of ulcer, so that there is burst bleeding
With severe complications such as perforation, should be noted that.Stomach or duodenal ulcer can be made during Long-Time Service to increase the weight of.Have being suitable for other
It is more easy to this side effect during medicine (such as aspirin, indometacin, butazolidin) of gastric irritation effect.To minority
Patient can induce pancreatitis or fatty liver.(5) cataract and glaucoma: glucocorticoid can induce cataract, whole body or local
It is administered and all can occur.Cataractous generation may suppress lens epithelium Na+-K+ pumping function with glucocorticoid, causes crystal
Fiber ponding is relevant with protein coagulation.Glucocorticoid can also make intraocular pressure raise, and induces glaucoma or makes glaucoma deteriorate,
Administered either systemically or locally all can occur, the reason that intraocular pressure raises being likely due to glucocorticoid makes eye anterior chamber angle trabecular network tie
The collagen bundle swelling of structure, caused by hindering aqueous humor circulation.(6) osteoporosis and vertebral compression fracture: osteoporosis and vertebra pressure
Compeling property fracture is that various age patient applies complication serious in glucocorticoid treatment.Rib with and vertebrae have height
Beam column construction, generally impacted the most serious.This may suppress osteoblast activity with glucocorticoid, increases the excretion of calcium phosphorus,
The absorption of suppression enteral calcium and increase osteocyte are relevant to factors such as the sensitiveness of parathormone.As there is osteoporosis
Then required drug withdrawal.For preventing and treating the suitable vitamin D of osteoporosis (vitamin D), calcium salt and protein anabolic hormone etc..(7) god
Through insanity: glucocorticoid can cause the abnormal behavior of various ways.Often can cover up the disease of some disease such as glad phenomenon
Shape and affect diagnosis adversely.And for example oversensitive, exciting, insomnia, Feeling changes or obvious psychotic symptoms even occurs.Some is sick
People also has introgression.Additionally, glucocorticoid is likely to induce epileptic attack.
Mainly affect gerontal patient due to giant cell arteritis, be different from general arteritis, therefore long-term employing sugar skin
Gerontal patient's body and mind is caused great burden by matter hormone therapy, and therefore, seeking a kind of new treatment means becomes urgently to be resolved hurrily
Problem.
Content of the invention
According to above the deficiencies in the prior art, the present invention provides a kind of Chinese medicine treating liver-kidney Yin deficiency type giant cell arteritis
Preparation, is particularly directed to the gerontal patient suffering from giant cell arteritis, and it is evident in efficacy, safe and reliable, have no side effect, and has
Wide potential applicability in clinical practice.
Liver-kidney Yin deficiency type giant cell arteritis has following Symptoms: patient's fatigue and weak, dizziness headache, back is sour
Bitterly, becoming thin, tinnitus dizziness, tongue nature is light red, and tongue is yellow, weak pulse.For this class patient, applicant proposes techniques below scheme:
A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis of the present invention, in parts by weight,
Formulated by following Chinese medicine material: wilson passionflower herb 15～20 parts, cynomorium songaricum 10～15 parts, the fruit of Chinese wolfberry 5～8 parts, eclipta 5～8 parts,
Semen astragali complanati 5～8 parts, the bighead atractylodes rhizome 5～8 parts, Bai Long wear coloured silk 15～20 parts, latifolious rush rhizome 10～15 parts, 10～15 parts of pocket orchid, hang yellow 5
～10 parts, ginseng 3～5 parts, keel 5～10 parts, the red root of herbaceous peony 5～10 parts.
Wherein, preferred version is as follows:
In parts by weight, formulated by following Chinese medicine material: wilson passionflower herb 15 parts, cynomorium songaricum 10 parts, the fruit of Chinese wolfberry 5 parts,
Eclipta 5 parts, semen astragali complanati 5 parts, the bighead atractylodes rhizome 5 parts, Bai Long wear coloured silk 15 parts, latifolious rush rhizome 10 parts, blue 10 parts of pocket, hang yellow 5 parts, ginseng 3
Part, keel 5 parts, the red root of herbaceous peony 5 parts.
Also can be formulated by following Chinese medicine material in parts by weight: wilson passionflower herb 20 parts, cynomorium songaricum 15 parts, matrimony vine
Son 8 parts, eclipta 8 parts, semen astragali complanati 8 parts, the bighead atractylodes rhizome 8 parts, Bai Long wear coloured silk 20 parts, latifolious rush rhizome 15 parts, blue 15 parts of pocket, hang yellow 10
Part, ginseng 5 parts, keel 10 parts, the red root of herbaceous peony 10 parts.
Also can be formulated by following Chinese medicine material in parts by weight: wilson passionflower herb 18 parts, cynomorium songaricum 12 parts, matrimony vine
Son 6 parts, eclipta 6 parts, semen astragali complanati 7 parts, the bighead atractylodes rhizome 6 parts, Bai Long wear color 18 parts, latifolious rush rhizome 12 parts, blue 12 parts of pocket, hang yellow 8 parts,
Ginseng 4 parts, keel 8 parts, the red root of herbaceous peony 8 parts.
The preparation method of the Chinese medicine preparation for the treatment of liver-kidney Yin deficiency type giant cell arteritis of the present invention, according to lower section
Prepared by method: weigh Chinese medicine material according to formula and join in container, adds water and covers powder immersion 10～20 minutes, adds water not
Cross powder 3～5 centimetres, decoct with high heat and use slow fire boiling again instead 20～30 minutes to boiling, take filtrate；Then add water not
Powder 3～5 centimetres, decocts with high heat and uses slow fire boiling again instead 15～20 minutes to boiling, and then removing slag takes filtrate, twice filtrate
Merge.
During use, 200～300ml every time, sooner or later respectively once.
Pharmacology analysis:
Wilson passionflower herb: micro-hardship, temperature.Wines used as antirheumatic, filling liver kidney, promoting blood circulation for regulating menstruation, desinsection preventing malaria.The sliding pain of main air temperature, has a pain in the back, liver
Inflammation, cirrhosis, irregular menstruation, traumatic injury, fracture, malaria, roundworm disease.
Cynomorium songaricum: sweet, temperature.Return spleen, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, relax bowel.Soft for waist knee impotence, impotence is sliding
Essence, the dry constipation of intestines.
The fruit of Chinese wolfberry: sweet is flat.Return liver, kidney channel.Nourishing liver and kidney, benefiting shrewd head.Lose for consumptive disease essence, soreness of waist and knee joint, dizziness ear
Ringing, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is failed to understand.
Eclipta: sweet, sour, cold.Return kidney, Liver Channel.Nourishing liver and kidney, cooling blood and hemostasis.For tooth mobility, poliosis, dizzy
Dizzy tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatism and bleeding.
Semen astragali complanati: sweet, temperature.Return liver, kidney channel.Temperature filling liver kidney, controlling nocturnal emission with astringent drugs, contracting urine, improving eyesight.For lumbago due to the kidney deficiency, premature ejaculation of passing out semen,
Under gonorrhoea band, dribbling urination, dizziness blurred vision.
The bighead atractylodes rhizome: bitter, sweet, temperature.Return spleen, stomach warp.Strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension
Having loose bowels, phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
Bai Long wears coloured silk: hardship pungent, micro-, flat.Regulating menstruation and activating blood, clearing away heat and promoting diuresis.For postpartum abdominal pain, irregular menstruation, acute nephritis,
Uterine hemorrhage, mastitis, erysipelas, furuncle.
Latifolious rush rhizome: pungent, bitter is flat.Regulating qi-flowing for relieving pain, regulating menstruation and activating blood.Cure mainly stagnation of QI due to depression of the liver, pain in chest and hypochondrium, menstrual disorder, metrorrhagia
Carry inferior disease.
Pocket is blue: acid sweet, puckery, micro-, flat.Regulating menstruation and activating blood, anti-inflammatory analgetic.Cure mainly irregular menstruation, dysmenorrhoea, amenorrhoea, adnexitis, wing
Guang is scorching, hernia etc..
Hang Huang: Gan Xin, flat.Dispelling rheumatism, qi-restoratives is subsided a swelling, and regulating menstruation and activating blood cures cold, rheumatalgia pain, tuberculosis, oedema,
Puerperal asthenia, irregular menstruation, traumatic injury.
Ginseng: hardship sweet, micro-is flat.Return spleen, lung, the heart channel of Hang-Shaoyin.Reinforcing vital energy, multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid, calms the nerves.With
Yu Tixu is intended to take off, the cold weak pulse of limb, and insufficiency of the spleen food is few, and the deficiency syndrome of the lung is breathed with cough, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, and prolonged illness void is thin, palpitation with fear insomnia, sun
Impotence palace is cold；Heart failure, cardiogenic shock.
Keel: sweet, puckery are flat.Calmness, the puckery essence of arrest sweating, myogenic sore.For neurasthenia, palpitaition, have a sleepless night, dreaminess, from
Sweat, night sweat, seminal emission, the enuresis, uterine bleeding, under band；External application control sore for a long time burst do not hold back.
The red root of herbaceous peony: smell is bitter flat, nontoxic.Curing mainly perverse trend stomachache, removing blood-arthralgia, broken heavily fortified point is long-pending, fever and chills, sick tired, and pain relieving, profit is little
Just, benefit gas.
In medicament composing prescription of the present invention, wilson passionflower herb, cynomorium songaricum, the fruit of Chinese wolfberry, eclipta, semen astragali complanati, the bighead atractylodes rhizome nourish liver spleen kidney, replenishing essence
Benefit marrow；Bai Long wears coloured silk, latifolious rush rhizome, pocket is blue, hang Huang and blood nourishes blood, menstruation regulating qi-restoratives；Ginseng, keel, red root of herbaceous peony benefit help the motive, multiple
Arteries and veins takes off admittedly.
It is an advantage of the current invention that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.
All medicine phases tonify the liver and kidney with having, and nourish effect of essence and blood, for the liver-kidney Yin deficiency type giant cell arteritis treatment of gerontal patient
There is the features such as determined curative effect, instant effect, cure rate is high, have no side effect.
Outcome measure:
1st, case selection:
As the medicine for the treatment of giant cell arteritis, select giant cell arteritis patient 100 case to carry out clinical observation, and suffer from
Person belongs to the gerontal patient of liver-kidney Yin deficiency type, wherein male 42 cases, women 58 case, age 60-79 year, average age 69 years old.
2nd, medicine for treatment:
Patient takes medicine of the present invention, every time 200～300ml, and sooner or later each 7 days is once a course for the treatment of, according to the state of an illness even
Continuous taking 5-10 the course for the treatment of, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3rd, diagnostic criteria:
(1) 50 years old with sequela；(2) headache recently occurring；(3) Temporal Artery has tenderness, beats and weakens that (unprovoked artery is hard
Change)；(4) erythrocyte sedimentation rate ＞ 50mm/h；(5) Temporal Artery biopsy shows as with based on monocyte infiltration or granulomatous angiitis, often
See multinucleate giant cell.
Possess above 3, giant cell arteritis can be diagnosed.
4th, Outcome measure:
Cure: clinical symptoms, sign are wholly absent；
Effective: clinical symptoms, sign take a favorable turn；
Invalid: all diseases are unchanged.
4th, treatment results:
Curing 37 cases, effective 60 cases, invalid 3 cases, total effective rate is 97%.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis, in parts by weight, former by following Chinese medicine
Expect formulated: wilson passionflower herb 15 parts, cynomorium songaricum 10 parts, the fruit of Chinese wolfberry 5 parts, eclipta 5 parts, semen astragali complanati 5 parts, the bighead atractylodes rhizome 5 parts, Bai Long wear coloured silk
15 parts, latifolious rush rhizome 10 parts, blue 10 parts of pocket, hang yellow 5 parts, ginseng 3 parts, keel 5 parts, the red root of herbaceous peony 5 parts.
Embodiment 2:
A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis, in parts by weight, former by following Chinese medicine
Expect formulated: wilson passionflower herb 20 parts, cynomorium songaricum 15 parts, the fruit of Chinese wolfberry 8 parts, eclipta 8 parts, semen astragali complanati 8 parts, the bighead atractylodes rhizome 8 parts, Bai Long wear coloured silk
20 parts, latifolious rush rhizome 15 parts, blue 15 parts of pocket, hang yellow 10 parts, ginseng 5 parts, keel 10 parts, the red root of herbaceous peony 10 parts.
Embodiment 3:
A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis, in parts by weight, former by following Chinese medicine
Expect formulated: wilson passionflower herb 18 parts, cynomorium songaricum 12 parts, the fruit of Chinese wolfberry 6 parts, eclipta 6 parts, semen astragali complanati 7 parts, the bighead atractylodes rhizome 6 parts, Bai Long wear coloured silk
18 parts, latifolious rush rhizome 12 parts, blue 12 parts of pocket, hang yellow 8 parts, ginseng 4 parts, keel 8 parts, the red root of herbaceous peony 8 parts.
Embodiment 4:
Fill a prescription described in embodiment 1～3 and prepare the Chinese medicine system for the treatment of liver-kidney Yin deficiency type giant cell arteritis in accordance with the following methods
Agent: weigh Chinese medicine material according to formula and join in container, add water cover powder soak 10～20 minutes, add water not medicine
3～5 centimetres of face, decocts with high heat and uses slow fire boiling again instead 20～30 minutes to boiling, take filtrate；Then add water not powder
3～5 centimetres, decocting with high heat and using slow fire boiling again instead 15～20 minutes to boiling, then removing slag takes filtrate, and filtrate merges twice
?.
Claims (4)
1. the Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis, it is characterised in that in parts by weight, by with
Lower Chinese medicine material is formulated: wilson passionflower herb 15～20 parts, cynomorium songaricum 10～15 parts, the fruit of Chinese wolfberry 5～8 parts, eclipta 5～8 parts, Sha Yuan
Son 5～8 parts, the bighead atractylodes rhizome 5～8 parts, Bai Long wear coloured silk 15～20 parts, latifolious rush rhizome 10～15 parts, 10～15 parts of pocket orchid, hang yellow 5～10
Part, ginseng 3～5 parts, keel 5～10 parts, the red root of herbaceous peony 5～10 parts.
2. a kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis according to claim 1, it is characterised in that
In parts by weight, formulated by following Chinese medicine material: wilson passionflower herb 15 parts, cynomorium songaricum 10 parts, the fruit of Chinese wolfberry 5 parts, eclipta 5
Part, semen astragali complanati 5 parts, the bighead atractylodes rhizome 5 parts, Bai Long wear coloured silk 15 parts, latifolious rush rhizome 10 parts, blue 10 parts of pocket, hang Huang 5 parts, ginseng 3 parts, keel 5
Part, the red root of herbaceous peony 5 parts.
3. a kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis according to claim 1, it is characterised in that
In parts by weight, formulated by following Chinese medicine material: wilson passionflower herb 20 parts, cynomorium songaricum 15 parts, the fruit of Chinese wolfberry 8 parts, eclipta 8
Part, semen astragali complanati 8 parts, the bighead atractylodes rhizome 8 parts, Bai Long wear coloured silk 20 parts, latifolious rush rhizome 15 parts, blue 15 parts of pocket, hang Huang 10 parts, ginseng 5 parts, keel
10 parts, the red root of herbaceous peony 10 parts.
4. a kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis according to claim 1, it is characterised in that
In parts by weight, formulated by following Chinese medicine material: wilson passionflower herb 18 parts, cynomorium songaricum 12 parts, the fruit of Chinese wolfberry 6 parts, eclipta 6
Part, semen astragali complanati 7 parts, the bighead atractylodes rhizome 6 parts, Bai Long wear coloured silk 18 parts, latifolious rush rhizome 12 parts, blue 12 parts of pocket, hang Huang 8 parts, ginseng 4 parts, keel 8
Part, the red root of herbaceous peony 8 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610777785.2A CN106138744A (en) | 2016-08-23 | 2016-08-23 | A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610777785.2A CN106138744A (en) | 2016-08-23 | 2016-08-23 | A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis |
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ID=57344289
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| CN201610777785.2A Withdrawn CN106138744A (en) | 2016-08-23 | 2016-08-23 | A kind of Chinese medicine preparation treating liver-kidney Yin deficiency type giant cell arteritis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302637A (en) * | 2000-01-01 | 2001-07-11 | 同济医科大学附属同济医院 | Medicinal material resisting against human cytomegalovirus and its application in preparing medicines |
| CN101002917A (en) * | 2006-11-04 | 2007-07-25 | 于曼秋 | Chinese medicine for treating thromboangitis obliterans |
| CN102343073A (en) * | 2011-09-21 | 2012-02-08 | 王丽娟 | Medicament for treating vasculitis and cerebral infarction |
-
2016
- 2016-08-23 CN CN201610777785.2A patent/CN106138744A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302637A (en) * | 2000-01-01 | 2001-07-11 | 同济医科大学附属同济医院 | Medicinal material resisting against human cytomegalovirus and its application in preparing medicines |
| CN101002917A (en) * | 2006-11-04 | 2007-07-25 | 于曼秋 | Chinese medicine for treating thromboangitis obliterans |
| CN102343073A (en) * | 2011-09-21 | 2012-02-08 | 王丽娟 | Medicament for treating vasculitis and cerebral infarction |
Non-Patent Citations (2)
| Title |
|---|
| 叶一萍: "《叶一萍临证思辨辑要》", 31 January 2013 * |
| 龚廷贤: "《龚廷贤医学全书》", 31 March 2016 * |
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Application publication date: 20161123 |