CN106138534A - A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid and preparation method thereof - Google Patents
A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid and preparation method thereof Download PDFInfo
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- CN106138534A CN106138534A CN201610659014.3A CN201610659014A CN106138534A CN 106138534 A CN106138534 A CN 106138534A CN 201610659014 A CN201610659014 A CN 201610659014A CN 106138534 A CN106138534 A CN 106138534A
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- hippocampus
- radix
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- tendons
- activating
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Abstract
The invention discloses a kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid and preparation method thereof, belong to health care oral liquid field.The present invention includes: 28 parts of Hippocampus active extract extract mother solutions, 0.5 5 parts of Zaocyss, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendras are fermented the fermentation liquid after detoxification, and 0.5 5 parts of Radix Angelicae Pubescentiss, Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Aqueous extracts of Radix Glycyrrhizae in yeast bacterium solution.These Chinese medicines are prepared according to the combination principle of monarch, have effect of good relaxing muscles and tendons and activating QI and blood in the collateral；And Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, the fermented detoxification of Scolopendra in these Chinese medicines so that the oral liquid safety non-toxic of the present invention.Chinese medicine Hippocampus processes through bionical gastric juice and bionical intestinal juice, and the Hippocampus active extract moment obtained plays the effect of its warming the kidney to invigorate YANG, pain relieving and relaxing muscles and tendons and activating QI and blood in the collateral.
Description
Technical field
The present invention relates to health care oral liquid field, particularly to a kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid and preparation method thereof.
Background technology
Sprain, dampen, muscles and bones is ached, numb limbs and tense tendons, hemiplegia, half side physical handicaps, outer eye muscle etc., major part uses Western medicine
Treatment, curative effect is little, and brings certain toxic and side effects to patient, can't resolve the slight illness of reality, makes the quality of life of patient
Decline, even threat to life.
Saying from traditional Chinese medical science angle, alleviate above slight illness is relaxing muscles and tendons and activating QI and blood in the collateral at all, major part relaxing muscles and tendons and activating QI and blood in the collateral in prior art
Chinese medicine be medicine for external use, take effect slow, cure rate is low.
Summary of the invention
In order to make up above deficiency, the invention provides a kind of Hippocampus safe to use, that relaxing muscles and tendons and activating QI and blood in the collateral is effective and relax
Active oral liquid of muscle and preparation method thereof.
The technical scheme is that
A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including: 2-8 part Hippocampus active extract extract mother solution, 0.5-5 part Zaocys,
Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification, and 0.5-5 in yeast bacterium solution
Part Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the water of Radix Glycyrrhizae carry
Liquid.
Preferably, also include that adjuvant, described adjuvant include 0.02-0.5% potassium sorbate, enduring of 10-30%
White sugar and the xanthan gum of 0.05-1% colloid mill liquefaction.
Preferably, the preparation method of described Hippocampus active extract extract mother solution is as follows:
1) bionical gastric juice is prepared:
A. take, according to weight ratio or volume ratio 2:1-5:1, lactobacillus bacterium solution that concentration is 80-120cfu/ml and concentration is
The yeast bacterium solution of 80-120cfu/ml, mixes to obtain mixed bacteria liquid；
B. adding hydrogen ion concentration in described mixed bacteria liquid is the dilute hydrochloric acid of 1-5mol/L, and the pH value of regulation mixed liquor is extremely
0.9-4.0；
C. adding solid sodium chloride, the density of regulation solution is to 1.006-1.009g/ml, to ensure described bionical gastric juice
Osmotic pressure is equal to human gastric juice；
D. adding feed with balanced nutrients, described feed with balanced nutrients includes Rhizoma Dioscoreae powder and xanthan gum, described Rhizoma Dioscoreae powder and described Huang
The concentration of virgin rubber is 0.5-2g/100ml；
E. adding pepsin, described pepsic concentration is 0.5-2g/100ml；
F. adding stable regulation agent, described stable regulation agent includes sodium citrate and glucose, described sodium citrate dense
Degree is 1-3g/100ml, and the concentration of described glucose is 2-4g/100ml；
2) bionical intestinal juice is prepared:
A. the bacillus cereus bacterium solution that concentration is 80-120cfu/ml is taken；
B. in described bacillus cereus bacterium solution, add potassium dihydrogen phosphate solid and make described potassium dihydrogen phosphate solid dissolve, institute
Stating the concentration of potassium dihydrogen phosphate described in bionical intestinal juice is 0.5-1.2g/100ml；
C. the pancreatin aqueous solution that concentration is 2.5g/100ml-15g/100ml, pancreatin described in described bionical intestinal juice are added
Concentration is 0.5-10g/100ml；
D. the sodium hydroxide solution regulation PH to 8-10 using concentration to be 0.05-0.3mol/L；
3) take Chinese medicine Hippocampus, 20-80 mesh sieve is pulverized and crossed to Chinese medicine Hippocampus, obtain the Hippocampus powder of 20-80 mesh；
4) the Hippocampus powder of described 20-80 mesh is added described bionical gastric juice, 30-37 DEG C of temperature conditions bottom fermentation 12-
48h, Hippocampus powder described in described bionical gastric juice submergence；Every liter of bionical gastric juice adds 60-200 gram of Hippocampus powder；
5) medicine after fermentation uses aperture to be the micro-filtrate membrane filtration of 0.1-10um；
6) permeate of gained adds after micro-filtrate membrane filtration described bionical intestinal juice, use described bionical intestinal juice to regulate institute
The PH stating permeate is 6.8-7.2, obtains Hippocampus active extract extract mother solution.
Further, described lactobacillus is Kefir grains lactobacillus；Described yeast is saccharomyces cerevisiae；Described spore bar
Bacterium is basophilia bacillus subtilis.
Preferably, the preparation method of described fermentation liquid is as follows: take crow 10-40 part tip Serpentis, 10-40 part Pheretima (parched),
10-40 part Bombyx Batryticatus, 8-30 part Scorpio, 8-30 part Radix Aconiti Preparata, 1-6 part Radix Aconiti Kusnezoffii Preparata, 5-20 part Scolopendra, pulverize to obtain Chinese medicinal powder；50-
150kg Chinese medicinal powder ferments in 500-2000L yeast bacterium solution；The concentration of yeast bacterium solution is 50-1000cfu/mL.
Preferably, the acquisition methods of described Aqueous extracts is as follows: take 1-15 part Radix Angelicae Pubescentis, 1-12 part Radix Clematidis, 1-10 part
Rhizoma Homalomenae, 1-12 part Cortex Eucommiae, 1-15 part Radix Achyranthis Bidentatae, 1-12 part Radix Dipsaci, 1-10 part Fructus Chaenomelis, 1-30 part Caulis Spatholobi, 1-9 part Flos Carthami, 1-2
Part Ramulus Cinnamomi, 1-2 part Rhizoma Chuanxiong, 1-12 part Radix Angelicae Sinensis, 1-10 part Radix Glycyrrhizae, soak 40-60min, then heated and boiled, fried 30-
50 minutes, filter medicinal residues and obtain Aqueous extracts.
The preparation method of described Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including step:
1) take 2-8 part Hippocampus active extract extract mother solution and 0.5-5 part Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata,
Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, mix homogeneously；
2) add 0.5-5 part Aqueous extracts, stir 10-15 hour at 35-38 DEG C；
3) adding adjuvant, cross 100-300 mesh sieve, filtrate is Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid.
Hippocampus, sweet, temperature；Return liver, kidney channel；Warming the kidney to invigorate YANG, mass dissipating and swelling eliminating；For sexual impotence, the enuresis, suffering from a deficiency of the kidney and breathe heavily, lump in the abdomen amasss
Poly-, injury from falling down；External treatment carbuncle furuncle.Hippocampus processes through bionical gastric juice and bionical intestinal juice, and compatibility is more flexible.
Zaocys, sweet, flat；Return Liver Channel；Dispel the wind, dredging collateral, relieving convulsion；For rheumatoid arthritis stubborn, numbness contracture, middle air port eye is askew
Tiltedly, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Pheretima (parched), salty, cold；Return liver, spleen, bladder warp；Heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis；For unconsciousness due to high fever, infantile convulsion
Twitch, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Bombyx Batryticatus, salty, pungent, flat；Return liver, lung, stomach warp；Expelling wind for relieving convulsion, dissipating phlegm and resolving masses；For convulsion with spasms, laryngopharynx swelling and pain, skin
Skin pruritus, submandibular lymph nodes is scorching, facial paralysis.
Scorpio, pungent, flat；Return Liver Channel；Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain；For infantile convulsion, tic spasm, in
Air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Radix Aconiti Preparata, pungent, bitter, heat；GUIXIN, liver,kidney,spleen warp；Expelling wind and removing dampness, antalgic；For anemofrigid-damp arthralgia, arthritis
Bitterly, trusted subordinate's cold type of pain, colic of cold type has a pain, narcotic analgesic.
Radix Aconiti Kusnezoffii Preparata, pungent, bitter, heat；GUIXIN, liver,kidney,spleen warp；Expelling wind and removing dampness, antalgic；For anemofrigid-damp arthralgia, arthritis
Bitterly, trusted subordinate's cold type of pain, colic of cold type has a pain, narcotic analgesic.
Scolopendra, pungent, temperature；Return Liver Channel；Endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain；For infantile convulsion, tic spasm, in
Air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Radix Angelicae Pubescentis, pungent, bitter, tepor；Return kidney, bladder warp；Expelling wind and removing dampness, numbness relieving and pain relieving；For anemofrigid-damp arthralgia, lumbocrural pain,
Few the moon volt wind headache.
Radix Clematidis, can declare and dredge the five internal organs, current twelve channels and collaterals；Control apoplexy gout, wind syndrome of head insensitive impediment.
Rhizoma Homalomenae, bitter, pungent, temperature；Return liver, kidney channel；Wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain；For anemofrigid-damp arthralgia, waist knee joint is cold
Bitterly, lower limb contracture is numb.
The Cortex Eucommiae, sweet, temperature；Return liver, kidney channel；Invigorating the liver and kidney, bone and muscle strengthening, antiabortive；For lumbago due to renal deficiency, muscles and bones is unable, gestation leakage
Blood, frequent fetal movement；Hypertension.
Radix Achyranthis Bidentatae, bitter, sour, flat；Return liver, kidney channel；Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards；For soreness of waist and knee joint,
Muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Dipsaci, bitter, pungent, tepor；Return liver, kidney channel；Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia；For soreness of the waist and knees, wind
Pain of dampness syndrome, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down；Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.
Fructus Chaenomelis, acid, temperature；Return liver, spleen channel；Suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness；For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid,
Vomit and diarrhoea and have a cramp, tinea pedis edema.
Caulis Spatholobi, bitter, sweet, temperature；Return liver, kidney channel；Enrich blood, invigorate blood circulation, dredging collateral；For menoxenia, blood deficiency and yellow complexion, numb paralysis
Paralysis, rheumatic arthralgia.
Flos Carthami, pungent, temperature；GUIXIN, Liver Channel；Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain；For amenorrhea, dysmenorrhea, lochia, lump in the abdomen painful abdominal mass
Block, injury from falling down, skin infection swells and ache.
Ramulus Cinnamomi, acrid, sweet, warm；GUIXIN, lung, bladder warp；Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins；For
Anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Rhizoma Chuanxiong, pungent, temperature；Return liver, gallbladder, pericardium channel；Blood-activating and qi-promoting, wind-expelling pain-stopping；For menoxenia, amenorrhea dysmenorrhea, disease
Abdominal mass is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Radix Angelicae Sinensis, sweet, acrid, warm；Return liver, the heart, spleen channel；Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation；For blood deficiency and yellow complexion, dizzy
Dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores；Radix Angelicae Sinensis (processed with wine)
Promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Glycyrrhizae, sweet, flat；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, it is in harmonious proportion all
Medicine；For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, abirritant
Thing toxicity, strong.
The invention have the benefit that
In the Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid of the present invention containing Hippocampus, Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata,
Radix Aconiti Kusnezoffii Preparata, Scolopendra, Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Radix Glycyrrhizae, these Chinese medicines are prepared according to the combination principle of monarch, are had effect of good relaxing muscles and tendons and activating QI and blood in the collateral；Hippocampus is as monarch
Medicine, Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra as ministerial drug, Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae,
Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Glycyrrhizae are as making medicine.And Zaocys, stir-fry in these Chinese medicines
Pheretima, Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, the fermented detoxification of Scolopendra so that the oral liquid safety non-toxic of the present invention.Chinese medicine sea
Horse processes through bionical gastric juice and bionical intestinal juice, obtains Hippocampus active extract extract mother solution, and compatibility is more flexible.
Detailed description of the invention
Embodiment 1
A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including 3 parts of Hippocampus active extract extract mother solutions, 1 part of Zaocys, Pheretima (parched),
Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification, and 1 part of Radix Angelicae Pubescentis, spirit in yeast bacterium solution
Celestial being, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Aqueous extracts of Radix Glycyrrhizae.
The preparation method of Hippocampus active extract extract mother solution is as follows:
1) bionical gastric juice is prepared:
A. take, according to weight ratio 3:1, Kefir grains lactobacillus bacterium solution that concentration is 100cfu/ml and concentration is 100cfu/ml's
Saccharomyces cerevisiae bacterium solution, mixes to obtain mixed bacteria liquid；
B. adding hydrogen ion concentration in described mixed bacteria liquid is the dilute hydrochloric acid of 2mol/L, and the pH value of regulation mixed liquor is extremely
3.0；
C. adding solid sodium chloride, the density of regulation solution is to 1.007g/ml, to ensure the osmotic pressure of described bionical gastric juice
It is equal to human gastric juice；
D. adding feed with balanced nutrients, described feed with balanced nutrients includes Rhizoma Dioscoreae powder and xanthan gum, described Rhizoma Dioscoreae powder and described Huang
The concentration of virgin rubber is 1g/100ml；
E. adding pepsin, described pepsic concentration is 1g/100ml；
F. adding stable regulation agent, described stable regulation agent includes sodium citrate and glucose, described sodium citrate dense
Degree is 2g/100ml, and the concentration of described glucose is 3g/100ml；
2) bionical intestinal juice is prepared:
A. the basophilia bacillus subtilis bacterium solution that concentration is 100cfu/ml is taken；
B. in described bacillus cereus bacterium solution, add potassium dihydrogen phosphate solid and make described potassium dihydrogen phosphate solid dissolve, institute
Stating the concentration of potassium dihydrogen phosphate described in bionical intestinal juice is 0.8g/100ml；
C. adding the pancreatin aqueous solution that concentration is 8g/100ml, described in described bionical intestinal juice, the concentration of pancreatin is 6g/
100ml；
D. the sodium hydroxide solution regulation PH to 9 using concentration to be 0.15mol/L；
3) take Chinese medicine Hippocampus, 60 mesh sieves are pulverized and crossed to Chinese medicine Hippocampus, obtain the Hippocampus powder of 60 mesh；
4) the Hippocampus powder of described 60 mesh is added described bionical gastric juice, 35 DEG C of temperature conditions bottom fermentation 24h, described bionical
Hippocampus powder described in gastric juice submergence；Every liter of bionical gastric juice adds 100 grams of Hippocampus powder；
5) medicine after fermentation uses aperture to be the micro-filtrate membrane filtration of 3um；
6) permeate of gained adds after micro-filtrate membrane filtration described bionical intestinal juice, use described bionical intestinal juice to regulate institute
The PH stating permeate is 6.8-7.2, obtains Hippocampus active extract extract mother solution.
The preparation method of fermentation liquid is as follows: take crow 25 parts of tip Serpentiss, 25 parts of Pheretima (parched), 25 parts of Bombyx Batryticatus, 19 parts of Scorpios, 19 parts of systems
Radix Aconiti, 3 parts of Radix Aconiti Kusnezoffii Preparatas, 12 parts of Scolopendras, pulverize to obtain Chinese medicinal powder；100kg Chinese medicinal powder ferments in 1000L yeast bacterium solution；
The concentration of yeast bacterium solution is 300cfu/mL.
The acquisition methods of Aqueous extracts is as follows: take 8 parts of Radix Angelicae Pubescentiss, 6 parts of Radix Clematidis, 6 parts of Rhizoma Homalomenaes, 6 parts of Cortexs Eucommiae, 8 parts of Radix Achyranthis Bidentataes, 6 parts
Radix Dipsaci, 6 portions of Fructus Chaenomeliss, 15 portions of Caulis Spatholobis, 5 portions of Flos Carthamis, 2 portions of Ramulus Cinnamomi, 1 portion of Rhizoma Chuanxiong, 6 portions of Radix Angelicae Sinensis, 5 portions of Radix Glycyrrhizaes, soak
50min, then heated and boiled, fried 40 minutes, filter medicinal residues and obtain Aqueous extracts.
The preparation method of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including step:
1) 3 parts of Hippocampus active extract extract mother solutions and 1 part of Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, system grass are taken
Crow, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, mix homogeneously；
2) add 1 part of Aqueous extracts, stir 12 hours at 37 DEG C；
3) potassium sorbate, the white sugar of enduring and the xanthan gum of colloid mill liquefaction are added.Crossing 100 mesh sieves, filtrate is Hippocampus
Relaxing muscles and tendons and activating QI and blood in the collateral oral liquid；Wherein, potassium sorbate accounts for the 0.2% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, and white sugar accounts for Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral mouth
Taking the 20% of liquid, xanthan gum accounts for the 0.5% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid.
Embodiment 2
A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including 5 parts of Hippocampus active extract extract mother solutions, 1 part of Zaocys, Pheretima (parched),
Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification, and 2 parts of Radix Angelicae Pubescentiss, spirits in yeast bacterium solution
Celestial being, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Aqueous extracts of Radix Glycyrrhizae.
The preparation method of Hippocampus active extract extract mother solution is as follows:
1) bionical gastric juice is prepared:
A. take, according to weight ratio 4:1, Kefir grains lactobacillus bacterium solution that concentration is 110cfu/ml and concentration is 110cfu/ml's
Saccharomyces cerevisiae bacterium solution, mixes to obtain mixed bacteria liquid；
B. adding hydrogen ion concentration in described mixed bacteria liquid is the dilute hydrochloric acid of 3mol/L, and the pH value of regulation mixed liquor is extremely
4.0；
C. adding solid sodium chloride, the density of regulation solution is to 1.009g/ml, to ensure the osmotic pressure of described bionical gastric juice
It is equal to human gastric juice；
D. adding feed with balanced nutrients, described feed with balanced nutrients includes Rhizoma Dioscoreae powder and xanthan gum, described Rhizoma Dioscoreae powder and described Huang
The concentration of virgin rubber is 1.5g/100ml；
E. adding pepsin, described pepsic concentration is 0.8g/100ml；
F. adding stable regulation agent, described stable regulation agent includes sodium citrate and glucose, described sodium citrate dense
Degree is 3g/100ml, and the concentration of described glucose is 2g/100ml；
2) bionical intestinal juice is prepared:
A. the basophilia bacillus subtilis bacterium solution that concentration is 110cfu/ml is taken；
B. in described bacillus cereus bacterium solution, add potassium dihydrogen phosphate solid and make described potassium dihydrogen phosphate solid dissolve, institute
Stating the concentration of potassium dihydrogen phosphate described in bionical intestinal juice is 1g/100ml；
C. adding the pancreatin aqueous solution that concentration is 5g/100ml, described in described bionical intestinal juice, the concentration of pancreatin is 3g/
100ml；
D. the sodium hydroxide solution regulation PH to 9 using concentration to be 0.1mol/L；
3) take Chinese medicine Hippocampus, 60 mesh sieves are pulverized and crossed to Chinese medicine Hippocampus, obtain the Hippocampus powder of 60 mesh；
4) the Hippocampus powder of described 60 mesh is added described bionical gastric juice, 35 DEG C of temperature conditions bottom fermentation 24h, described bionical
Hippocampus powder described in gastric juice submergence；Every liter of bionical gastric juice adds 120 grams of Hippocampus powder；
5) medicine after fermentation uses aperture to be the micro-filtrate membrane filtration of 1um；
6) permeate of gained adds after micro-filtrate membrane filtration described bionical intestinal juice, use described bionical intestinal juice to regulate institute
The PH stating permeate is 6.8-7.2, obtains Hippocampus active extract extract mother solution.
The preparation method of fermentation liquid is as follows: take crow 35 parts of tip Serpentiss, 15 parts of Pheretima (parched), 20 parts of Bombyx Batryticatus, 12 parts of Scorpios, 22 parts of systems
Radix Aconiti, 6 parts of Radix Aconiti Kusnezoffii Preparatas, 8 parts of Scolopendras, pulverize to obtain Chinese medicinal powder；100kg Chinese medicinal powder ferments in 1200L yeast bacterium solution；Ferment
The concentration of female bacterium bacterium solution is 500cfu/mL.
The acquisition methods of Aqueous extracts is as follows: take 13 parts of Radix Angelicae Pubescentiss, 10 parts of Radix Clematidis, 8 parts of Rhizoma Homalomenaes, 3 parts of Cortexs Eucommiae, 12 parts of Radix Achyranthis Bidentataes, 8
Part Radix Dipsaci, 5 portions of Fructus Chaenomeliss, 25 portions of Caulis Spatholobis, 2 portions of Flos Carthamis, 1 portion of Ramulus Cinnamomi, 2 portions of Rhizoma Chuanxiongs, 10 portions of Radix Angelicae Sinensis, 8 portions of Radix Glycyrrhizaes, soak
40min, then heated and boiled, fried 50 minutes, filter medicinal residues and obtain Aqueous extracts.
The preparation method of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including step:
1) 5 parts of Hippocampus active extract extract mother solutions and 1 part of Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, system grass are taken
Crow, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, mix homogeneously；
2) add 2 parts of Aqueous extracts, stir 12 hours at 37 DEG C；
3) potassium sorbate, the white sugar of enduring and the xanthan gum of colloid mill liquefaction are added.Crossing 200 mesh sieves, filtrate is Hippocampus
Relaxing muscles and tendons and activating QI and blood in the collateral oral liquid；Wherein, potassium sorbate accounts for the 0.1% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, and white sugar accounts for Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral mouth
Taking the 15% of liquid, xanthan gum accounts for the 0.2% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid.
Embodiment 3
A kind of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including: 5 parts of Hippocampus active extract extract mother solutions, 0.6 part of Zaocys, stir-fry ground
Dragon, Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, and 3 parts of Radix Angelicae Pubescentiss,
Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Aqueous extracts of Radix Glycyrrhizae.
The preparation method of Hippocampus active extract extract mother solution is as follows:
1) bionical gastric juice is prepared:
A. take, according to weight ratio 3:1, Kefir grains lactobacillus bacterium solution that concentration is 100cfu/ml and concentration is 100cfu/ml's
Saccharomyces cerevisiae bacterium solution, mixes to obtain mixed bacteria liquid；
B. adding hydrogen ion concentration in described mixed bacteria liquid is the dilute hydrochloric acid of 2mol/L, and the pH value of regulation mixed liquor is extremely
3.0；
C. adding solid sodium chloride, the density of regulation solution is to 1.007g/ml, to ensure the osmotic pressure of described bionical gastric juice
It is equal to human gastric juice；
D. adding feed with balanced nutrients, described feed with balanced nutrients includes Rhizoma Dioscoreae powder and xanthan gum, described Rhizoma Dioscoreae powder and described Huang
The concentration of virgin rubber is 1g/100ml；
E. adding pepsin, described pepsic concentration is 1g/100ml；
F. adding stable regulation agent, described stable regulation agent includes sodium citrate and glucose, described sodium citrate dense
Degree is 2g/100ml, and the concentration of described glucose is 3g/100ml；
2) bionical intestinal juice is prepared:
A. the basophilia bacillus subtilis bacterium solution that concentration is 100cfu/ml is taken；
B. in described bacillus cereus bacterium solution, add potassium dihydrogen phosphate solid and make described potassium dihydrogen phosphate solid dissolve, institute
Stating the concentration of potassium dihydrogen phosphate described in bionical intestinal juice is 0.8g/100ml；
C. adding the pancreatin aqueous solution that concentration is 8g/100ml, described in described bionical intestinal juice, the concentration of pancreatin is 6g/
100ml；
D. the sodium hydroxide solution regulation PH to 9 using concentration to be 0.15mol/L；
3) take Chinese medicine Hippocampus, 60 mesh sieves are pulverized and crossed to Chinese medicine Hippocampus, obtain the Hippocampus powder of 60 mesh；
4) the Hippocampus powder of described 60 mesh is added described bionical gastric juice, 35 DEG C of temperature conditions bottom fermentation 24h, described bionical
Hippocampus powder described in gastric juice submergence；Every liter of bionical gastric juice adds 80 grams of Hippocampus powder；
5) medicine after fermentation uses aperture to be the micro-filtrate membrane filtration of 5um；
6) permeate of gained adds after micro-filtrate membrane filtration described bionical intestinal juice, use described bionical intestinal juice to regulate institute
The PH stating permeate is 6.8-7.2, obtains Hippocampus active extract extract mother solution.
The preparation method of fermentation liquid is as follows: take crow 20 parts of tip Serpentiss, 25 parts of Pheretima (parched), 25 parts of Bombyx Batryticatus, 19 parts of Scorpios, 10 parts of systems
Radix Aconiti, 3 parts of Radix Aconiti Kusnezoffii Preparatas, 10 parts of Scolopendras, pulverize to obtain Chinese medicinal powder；100kg Chinese medicinal powder ferments in 1000L yeast bacterium solution；
The concentration of yeast bacterium solution is 300cfu/mL.
The acquisition methods of Aqueous extracts is as follows: take 12 parts of Radix Angelicae Pubescentiss, 3 parts of Radix Clematidis, 6 parts of Rhizoma Homalomenaes, 6 parts of Cortexs Eucommiae, 8 parts of Radix Achyranthis Bidentataes, 3 parts
Radix Dipsaci, 10 portions of Fructus Chaenomeliss, 15 portions of Caulis Spatholobis, 2 portions of Flos Carthamis, 2 portions of Ramulus Cinnamomi, 1 portion of Rhizoma Chuanxiong, 6 portions of Radix Angelicae Sinensis, 5 portions of Radix Glycyrrhizaes, soak
50min, then heated and boiled, fried 40 minutes, filter medicinal residues and obtain Aqueous extracts.
The preparation method of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, including step:
1) 5 parts of Hippocampus active extract extract mother solutions and 0.6 part of Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, system grass are taken
Crow, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, mix homogeneously；
2) add 3 parts of Aqueous extracts, stir 12 hours at 37 DEG C；
3) potassium sorbate, the white sugar of enduring and the xanthan gum of colloid mill liquefaction are added.Crossing 300 mesh sieves, filtrate is Hippocampus
Relaxing muscles and tendons and activating QI and blood in the collateral oral liquid；Wherein, potassium sorbate accounts for the 0.2% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, and white sugar accounts for Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral mouth
Taking the 20% of liquid, xanthan gum accounts for the 0.5% of Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid.
Claims (7)
1. a Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, it is characterised in that including: 2-8 part Hippocampus active extract extract mother solution, 0.5-5
Part Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution,
And it is 0.5-5 part Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Homalomenae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Chaenomelis, Caulis Spatholobi, Flos Carthami, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, sweet
The Aqueous extracts of grass.
2. Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid as claimed in claim 1, it is characterised in that also include that adjuvant, described adjuvant include
0.02-0.5% potassium sorbate, the white sugar of enduring of 10-30% and the xanthan gum of 0.05-1% colloid mill liquefaction.
3. Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid as claimed in claim 1 or 2, it is characterised in that described Hippocampus active extract extract is female
The preparation method of liquid is as follows:
1) bionical gastric juice is prepared:
A. take, according to weight ratio or volume ratio 2:1-5:1, lactobacillus bacterium solution that concentration is 80-120cfu/ml and concentration is 80-
The yeast bacterium solution of 120cfu/ml, mixes to obtain mixed bacteria liquid；
B. adding hydrogen ion concentration in described mixed bacteria liquid is the dilute hydrochloric acid of 1-5mol/L, the pH value of regulation mixed liquor to 0.9-
4.0；
C. adding solid sodium chloride, the density of regulation solution is to 1.006-1.009g/ml, to ensure the infiltration of described bionical gastric juice
Pressure is equal to human gastric juice；
D. adding feed with balanced nutrients, described feed with balanced nutrients includes Rhizoma Dioscoreae powder and xanthan gum, described Rhizoma Dioscoreae powder and described xanthan gum
Concentration be 0.5-2g/100ml；
E. adding pepsin, described pepsic concentration is 0.5-2g/100ml；
F. adding stable regulation agent, described stable regulation agent includes that sodium citrate and glucose, the concentration of described sodium citrate are
1-3g/100ml, the concentration of described glucose is 2-4g/100ml；
2) bionical intestinal juice is prepared:
A. the bacillus cereus bacterium solution that concentration is 80-120cfu/ml is taken；
B. in described bacillus cereus bacterium solution, add potassium dihydrogen phosphate solid and make described potassium dihydrogen phosphate solid dissolve, described imitative
Described in raw intestinal juice, the concentration of potassium dihydrogen phosphate is 0.5-1.2g/100ml；
C. the pancreatin aqueous solution that concentration is 2.5g/100ml-15g/100ml, the concentration of pancreatin described in described bionical intestinal juice are added
For 0.5-10g/100ml；
D. the sodium hydroxide solution regulation PH to 8-10 using concentration to be 0.05-0.3mol/L；
3) take Chinese medicine Hippocampus, 20-80 mesh sieve is pulverized and crossed to Chinese medicine Hippocampus, obtain the Hippocampus powder of 20-80 mesh；
4) the Hippocampus powder of described 20-80 mesh is added described bionical gastric juice, 30-37 DEG C of temperature conditions bottom fermentation 12-48h, institute
State Hippocampus powder described in bionical gastric juice submergence；Every liter of bionical gastric juice adds 60-200 gram of Hippocampus powder；
5) medicine after fermentation uses aperture to be the micro-filtrate membrane filtration of 0.1-10um；
6) permeate of gained adds after micro-filtrate membrane filtration described bionical intestinal juice, use the regulation of described bionical intestinal juice described
The PH crossing liquid is 6.8-7.2, obtains Hippocampus active extract extract mother solution.
4. Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid as claimed in claim 3, it is characterised in that: described lactobacillus is Kefir grains breast bar
Bacterium；Described yeast is saccharomyces cerevisiae；Described bacillus cereus is basophilia bacillus subtilis.
5. Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid as claimed in claim 1, it is characterised in that the preparation method of described fermentation liquid is as follows:
Take crow 10-40 part tip Serpentis, 10-40 part Pheretima (parched), 10-40 part Bombyx Batryticatus, 8-30 part Scorpio, 8-30 part Radix Aconiti Preparata, 1-6 part system grass
Crow, 5-20 part Scolopendra, pulverize to obtain Chinese medicinal powder；50-150kg Chinese medicinal powder ferments in 500-2000L yeast bacterium solution；Yeast
The concentration of bacterium bacterium solution is 50-1000cfu/mL.
6. Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid as claimed in claim 1, it is characterised in that: the acquisition methods of described Aqueous extracts is as follows:
Take 1-15 part Radix Angelicae Pubescentis, 1-12 part Radix Clematidis, 1-10 part Rhizoma Homalomenae, 1-12 part Cortex Eucommiae, 1-15 part Radix Achyranthis Bidentatae, 1-12 part Radix Dipsaci, 1-10 part
Fructus Chaenomelis, 1-30 part Caulis Spatholobi, 1-9 part Flos Carthami, 1-2 part Ramulus Cinnamomi, 1-2 part Rhizoma Chuanxiong, 1-12 part Radix Angelicae Sinensis, 1-10 part Radix Glycyrrhizae, add water logging
Bubble 40-60min, then heated and boiled, fried 30-50 minute, filter medicinal residues and obtain Aqueous extracts.
7. the preparation method of as claimed in claim 1 Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid, it is characterised in that include step:
1) 2-8 part Hippocampus active extract extract mother solution and 0.5-5 part Zaocys, Pheretima (parched), Bombyx Batryticatus, Scorpio, Radix Aconiti Preparata, system grass are taken
Crow, Scolopendra are fermented the fermentation liquid after detoxification in yeast bacterium solution, mix homogeneously；
2) add 0.5-5 part Aqueous extracts, stir 10-15 hour at 35-38 DEG C；
3) adding adjuvant, cross 100-300 mesh sieve, filtrate is Hippocampus relaxing muscles and tendons and activating QI and blood in the collateral oral liquid.
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| CN1876157A (en) * | 2006-04-27 | 2006-12-13 | 张启栋 | A medicinal wine for treating rheumatic and rheumatoid disease |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN101095845A (en) * | 2007-07-16 | 2008-01-02 | 任重祥 | Century health preserving magical wine |
| CN103330924A (en) * | 2013-06-07 | 2013-10-02 | 朱民生 | Biological extraction method of traditional Chinese medicine activin |
| CN105434797A (en) * | 2015-12-23 | 2016-03-30 | 天津喜马拉雅健康科技有限公司 | Bone nourishing and body building oral liquid and preparation method thereof |
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2016
- 2016-08-11 CN CN201610659014.3A patent/CN106138534A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876157A (en) * | 2006-04-27 | 2006-12-13 | 张启栋 | A medicinal wine for treating rheumatic and rheumatoid disease |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN101095845A (en) * | 2007-07-16 | 2008-01-02 | 任重祥 | Century health preserving magical wine |
| CN103330924A (en) * | 2013-06-07 | 2013-10-02 | 朱民生 | Biological extraction method of traditional Chinese medicine activin |
| CN105434797A (en) * | 2015-12-23 | 2016-03-30 | 天津喜马拉雅健康科技有限公司 | Bone nourishing and body building oral liquid and preparation method thereof |
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