CN106138524A

CN106138524A - One is used for treating dermopathic compositions and preparation method thereof

Info

Publication number: CN106138524A
Application number: CN201610764566.0A
Authority: CN
Inventors: 李先文; 李海; 李江
Original assignee: Xinyang Normal University
Current assignee: Xinyang Normal University
Priority date: 2016-08-30
Filing date: 2016-08-30
Publication date: 2016-11-23

Abstract

The invention provides a kind of for treating dermopathic compositions and preparation method thereof, said composition is made up of according to constant weight proportioning Radix Sophorae Flavescentis, Pericarpium Zanthoxyli, Cortex Dictamni, Cortex Phellodendri, the Fructus Kochiae, Fructus Cnidii, Fructus Xanthii, Caulis Lonicerae, Radix Et Rhizoma Rhei, Cortex Meliae, pharmaceutically acceptable Aloe fresh goods and allantoin.The preparation method of a kind of medicament of said composition is: weigh above-mentioned front ten kinds of medical material components by weight, immerses in glacial acetic acid solution, adds stabilizer and pharmaceutically acceptable Aloe fresh goods, heated and boiled, separate to obtain liquid A and medicine residue；2) thing residue of getting it filled adds boiled water, and adds stabilizer and glacial acetic acid, and the post-heating that stirs boils, and adds pharmaceutically acceptable Aloe fresh goods, separates to obtain liquid B and medicine residue；3) take liquid A and liquid B mix homogeneously, add allantoin, centrifugation after naturally placing, to obtain final product.The present composition can be directly outer for affected part, has good efficacy to multiple dermatomycosis, and preparation component is simple, to skin zero damage.

Description

One is used for treating dermopathic compositions and preparation method thereof

Technical field

The present invention relates to a kind of for treating dermopathic compositions and preparation method thereof, belong to Chinese medicine formula technology neck Territory.

Background technology

Skin is the organ that human body is maximum, participates in body several functions movable.Skin is also that the first physiology of human body is prevented Line, maintains the unity of opposites of body and natural environment, and protection body is from the infringement of extraneous pathogenic microorganism.But, having (such as wound strain, six climate exopathogens invasion and attack, eating and drinking without temperance, seven emotions pent-up and pathogenic bacteria infringement etc.) in the case of Xie, some dermatosiss can be caused. Dermatosis is a kind of commonly encountered diseases, and most common of which has bacterial dermatosis, dermatomycosis (usually said tinea Sick) and physical property or biochemical dermatosis.At present by bacterial skin infection and physical property or biochemical dermatosis etc. There are more effective medical measure and medicine, although and treating by the medicine of actinomycetes and fungus-caused dermatomycosis Through there being many kinds (such as JIAOXIAN YICIJING, Da Kelin frost etc.), but they often have some limitations, such as therapeutic effect not Good, relatively big to skin irritation or infringement, the most greasy patient of making of medicine does not feels well.Therefore, exploitation is a kind of to fungoid skin Skin disease therapeutic effect is good, applied widely, easy to use, and non-stimulated to skin and infringement medicine has important value.

Summary of the invention

It is an object of the invention to provide a kind of for treating dermopathic compositions, though this medicament composition is simple, can be real The now effective healing to multiple dermatomycosis.

Further, it is another object of the present invention to provide this preparation method being used for treating dermopathic compositions, method Simply, the cycle is short, low cost.

In order to realize object above, the technical solution adopted in the present invention is:

One is used for treating dermopathic medicament, including the medicine of following weight portion: Radix Sophorae Flavescentis 1-1.5 part, Pericarpium Zanthoxyli 1-1.5 Part, Cortex Dictamni 1-1.5 part, Cortex Phellodendri 1-1.5 part, Fructus Kochiae 1-1.5 part, Fructus Cnidii 1-1.5 part, Fructus Xanthii 1-1.5 part, Caulis Lonicerae 1-1.5 part, Radix Et Rhizoma Rhei 1-1.5 part, Cortex Meliae 0.5-1 part, pharmaceutically acceptable Aloe fresh goods 15-25 part and allantoin 0.18～2.5 parts.Its In, Radix Sophorae Flavescentis bitter in the mouth, cold in nature, there is the effect of heat clearing and damp drying, eliminating fire and detoxication, clearing away deficiency-heat；Pericarpium Zanthoxyli acrid in the mouth, property heat, have warming middle-JIAO to relieve pain, The effect of antidiarrheal parasite killing；Cortex Dictamni bitter in the mouth, cold in nature, there is the effect of heat-clearing and toxic substances removing, removing damp to relieve itching；Cortex Phellodendri bitter in the mouth, cold in nature, there is heat clearing away Dampness, eliminating fire and detoxication, the effect of clearing away deficiency-heat；The Fructus Kochiae belongs to acrid in the mouth, hardship, cold in nature, has the effect of heat-clearing and toxic substances removing, removing damp to relieve itching； Fructus Cnidii acrid in the mouth, hardship, warm in nature, there are removing dampness and killing parasites, cold expelling to dispel the wind, the effect of warming the kidney to invigorate YANG；Fructus Xanthii acrid in the mouth, hardship, warm in nature, have scattered Rheumatism, clearing the nasal passage, the effect of pain relieving；Caulis Lonicerae sweet in the mouth, cold in nature, there are heat-clearing and toxic substances removing, the effect of dispelling wind dredging collateral；Radix Et Rhizoma Rhei bitter in the mouth, property Cold, have heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, stimulate the menstrual flow by becoming silted up, the effect of dampness removing jaundice eliminating；Cortex Meliae bitter in the mouth, cold in nature, have clear Hot dampness, parasite killing treat the effect of tinea；Pharmaceutically acceptable Aloe bitter in the mouth, cold in nature, there is the effect that removing toxic substances is anti-ageing, sterilization antiinflammatory, heart tonifying are invigorated blood circulation.

Described pharmaceutically acceptable Aloe is Aloe vulgaris, Aloe arborescens var. natalensis, Aloe vera L.var. chinensis(Haw.)Berg., aloe ferrox or A.saponaria, this Bright preferred Aloe vulgaris.

Described compositions is exterior-applied formulation, and wherein said exterior-applied formulation is solution, spray, lotion, tincture, cream, cream Agent, paste or powder.

Described exterior-applied formulation is spray, and spray uses process convenient, is sprayed at affected part and does not haves greasy feeling, makes patient feel Feel pleasant.

Described constituent also includes water 180～280 parts, glacial acetic acid 1.8～8.4 parts and stabilizer 1.8～2.8 parts.

Described stabilizer is polyvinylpyrrolidone, gellan gum, ceteareth-20, xanthan gum or carbomer.

This preparation method being used for treating dermopathic compositions, comprises the following steps, and following component is by weight Meter:

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 50～70 DEG C containing 90～140 parts of water and 0.9～ In the solution of 4.2 parts of glacial acetic acids 1～2h, add stabilizer 0.9～1.4 parts, heated and boiled 5min, add afterwards smash to pieces can medicine With Aloe fresh goods 7.5～12.5 parts, continue heated and boiled 5min, be incubated 5～20min, separate to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 90～140 parts of boiled water, and add stabilizer 0.9～1.4 parts and glacial acetic acid 0.9～ 4.2 parts, the post-heating that stirs boils 5min, adds 7.5～12.5 parts of pharmaceutically acceptable Aloe fresh goods smashed to pieces afterwards, continues heating Boil 5min, be incubated 5～20min, separate to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, addition allantoin 0.18～2.5 parts, after naturally placing 1～3 day, be centrifuged Removing precipitation, the supernatant of gained is this product.

This method both can ensure that effective dissolution of ingredient, can reduce again decomposition to greatest extent and convert, protecting Demonstrate,prove the stable lasting of product quality, it is not necessary to add preservative and just can at room temperature preserve 2 years.

Described parameter of noncentricity is 5000～10000r/min, and the time is 5～10min.

Described step 1) in pharmaceutically acceptable Aloe be Aloe vulgaris, Aloe arborescens var. natalensis, Aloe vera L.var. chinensis(Haw.)Berg., aloe ferrox or soap matter Aloe.

Every taste Chinese medicine used in the present invention all plays each self-applying, and wherein Pericarpium Zanthoxyli can dissipate pathogenic wind toxic with penetrating skin；Aloe Can protect skin, sterilize antiinflammatory；Caulis Lonicerae, Radix Et Rhizoma Rhei can be with blood circulation promoting and blood stasis dispelling；Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri, the Fructus Kochiae, Fructus Cnidii, Fructus Xanthii and Cortex Meliae have suppression or killing action to various dermatophytes, and reach the effect of dispelling wind for relieving itching pain relieving；Allantois Have promotion cell growth, the effect of horny layer softening albumen.Mutually synergism is played, it is achieved to respectively between each drug component The therapeutic effect that class dermatosis is good.Drug component of the present invention is simple and easy to get, and medicine is with low cost, and fabrication cycle is short, to skin Nonirritant is damaged, and patient uses process more convenient pleasant, and has good effect to multiple dermatosis.

It is good to multiple dermatomycosis therapeutic effect that being used for of the present invention treats dermopathic compositions, can effectively control Treat the multiple dermatosis such as tinea, trick cracked skin.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further detailed explanation.

Embodiment 1

Being used for of the present embodiment treats dermopathic compositions, including the medicine of following weight portion: Radix Sophorae Flavescentis 1 part, Pericarpium Zanthoxyli 1 Part, Cortex Dictamni 1 part, Cortex Phellodendri 1 part, the Fructus Kochiae 1 part, Fructus Cnidii 1 part, Fructus Xanthii 1 part, Caulis Lonicerae 1 part, Radix Et Rhizoma Rhei 1 part, Cortex Meliae 0.5 part, Aloe vulgaris fresh goods 15 parts, allantoin 0.18 part.

This preparation method being used for treating dermopathic compositions, comprises the following steps:

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 50 DEG C containing 90 parts of water and 0.9 part of glacial acetic acid 2h in solution, adds polyvinylpyrrolidone 0.9 part, heated and boiled 5min, adds the Aloe vulgaris fresh goods 7.5 smashed to pieces afterwards Part, continue heated and boiled 5min, be incubated 20min, be centrifuged 15min in 5000r/min, separate to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds 90 parts of boiled water, and adds polyvinylpyrrolidone 0.9 part and glacial acetic acid 0.9 part, stirring Uniformly post-heating boils 5min, adds 7.5 parts of Aloe vulgaris fresh goods smashed to pieces afterwards, continues heated and boiled 5min, insulation 20min, is centrifuged 15min in 5000r/min, separates to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, add allantoin 0.18 part, naturally after placement 1 day, in 5000r/min from Heart 15min, removes precipitation, and the supernatant of gained is this product.

Embodiment 2

Being used for of the present embodiment treats dermopathic compositions, including the medicine of following weight portion: Radix Sophorae Flavescentis 1.2 parts, Pericarpium Zanthoxyli 1.2 parts, Cortex Dictamni 1.2 parts, Cortex Phellodendri 1.4 parts, the Fructus Kochiae 1.2 parts, Fructus Cnidii 1.4 parts, Fructus Xanthii 1.4 parts, Caulis Lonicerae 1.4 parts, Radix Et Rhizoma Rhei 1.4 parts, Cortex Meliae 0.7 part, aloe ferrox fresh goods 18 parts, allantoin 1.3 parts.

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 59 DEG C containing 100 parts of water and 1.9 parts of glacial acetic acids 1.8h in solution, adds gellan gum 1.2 parts, heated and boiled 5min, adds the aloe ferrox fresh goods 9 parts smashed to pieces afterwards, continue to add Heat boils 5min, is incubated 15min, is centrifuged 20min in 8000r/min, separates to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 100 parts of boiled water, and adds gellan gum 1.0 parts and glacial acetic acid 1.9 parts, after stirring Heated and boiled 5min, adds 9 parts of aloe ferrox fresh goods smashed to pieces afterwards, continues heated and boiled 5min, be incubated 15min, in 8000r/min is centrifuged 20min, separates to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, add allantoin 1.3 parts, after naturally placing 1.8 days, in 8000r/min Centrifugal 20min, removes precipitation, and the supernatant of gained is this product.

Embodiment 3

Being used for of the present embodiment treats dermopathic compositions, including the medicine of following weight portion: Radix Sophorae Flavescentis 1.4 parts, Pericarpium Zanthoxyli 1.3 parts, Cortex Dictamni 1.3 parts, Cortex Phellodendri 1.2 parts, the Fructus Kochiae 1.4 parts, Fructus Cnidii 1.3 parts, Fructus Xanthii 1.2 parts, Caulis Lonicerae 1.2 parts, Radix Et Rhizoma Rhei 1.3 parts, Cortex Meliae 0.8 part, Aloe vulgaris fresh goods 22 parts, allantoin 2.1 parts.

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 56 DEG C containing 120 parts of water and 3.5 parts of glacial acetic acids 1.8h in solution, adds polyvinylpyrrolidone 1.25 parts, heated and boiled 5min, adds the aloe ferrox fresh goods 12 smashed to pieces afterwards Part, continue heated and boiled 5min, be incubated 15min, be centrifuged 20min in 8000r/min, separate to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 120 parts of boiled water, and adds polyvinylpyrrolidone 1.25 parts and glacial acetic acid 3.2 parts, The post-heating that stirs boils 5min, adds 10 parts of aloe ferrox fresh goods smashed to pieces afterwards, continues heated and boiled 5min, insulation 15min, is centrifuged 20min in 8000r/min, separates to obtain liquid B and medicine residue；

3) taking liquid A and liquid B mix homogeneously, add allantoin 1.5 parts, placement is two days later naturally, in 8000r/min from Heart 20min, separates to obtain liquid C；

4) step 3 is taken) gained liquid C is concentrated in vacuo, and make volume become original 20%, add 0.4 part of card ripple Nurse, 2 parts of glyceryl stearate and 2 parts of ceteareth-20, stirring, to being completely dissolved, obtains solution D；

5) 0.2 part of calcium chloride and the glycerol of solution D cumulative volume 2% and step 4 are taken) gained solution D mixes, stirs, Add the essence of total liquid volume 0.01%, be uniformly mixed, to obtain final product.

Embodiment 4

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 55 DEG C containing 120 parts of water and 3.35 parts of glacial acetic acids Solution in 1.5h, add xanthan gum 1.25 parts, heated and boiled 5min, add the aloe ferrox fresh goods 11 parts smashed to pieces afterwards, continue Continuous heated and boiled 5min, is incubated 18min, is centrifuged 20min in 8000r/min, separates to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 120 parts of boiled water, and adds xanthan gum 1.25 parts and glacial acetic acid 2.3 parts, stirs Post-heating boils 5min, adds 11 parts of aloe ferrox fresh goods smashed to pieces afterwards, continues heated and boiled 5min, is incubated 15min, in 8000r/min is centrifuged 20min, separates to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, add allantoin 2.1 parts, after naturally placing 1.6 days, in 8000r/min Centrifugal 20min, removes precipitation, and the supernatant of gained is this product.

Embodiment 5

Being used for of the present embodiment treats dermopathic compositions, including the medicine of following weight portion: Radix Sophorae Flavescentis 1.5 parts, Pericarpium Zanthoxyli 1.5 parts, Cortex Dictamni 1.5 parts, Cortex Phellodendri 1.5 parts, the Fructus Kochiae 1.5 parts, Fructus Cnidii 1.5 parts, Fructus Xanthii 1.5 parts, Caulis Lonicerae 1.5 parts, Radix Et Rhizoma Rhei 1.5 parts, Cortex Meliae 1 part, Aloe vulgaris fresh goods 25 parts, allantoin 2.5 parts.

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 70 DEG C containing 140 parts of water and 4.2 parts of glacial acetic acids 1h in solution, adds carbomer 1.4 parts, heated and boiled 5min, adds the Aloe vulgaris fresh goods 12.5 parts smashed to pieces afterwards, continues Heated and boiled 5min, is incubated 5min, is centrifuged 10min in 10000r/min, separates to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 140 parts of boiled water, and adds carbomer 1.4 parts and glacial acetic acid 4.2 parts, after stirring Heated and boiled 5min, adds 12.5 parts of Aloe vulgaris fresh goods smashed to pieces afterwards, continues heated and boiled 5min, be incubated 5min, in 10000r/min is centrifuged 10min, separates to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, add allantoin 2.5 parts, naturally after placement 3 days, in 10000r/min from Heart 10min, removes precipitation, and the supernatant of gained is this product.

Experimental example 1

Tinea pedis is common during people live, and by fungus-caused tinea, has infectiousness, can be passed by close contact Broadcast.Once showing effect, make people often feel very to itch unbearably, occur erythema, blister, desquamation between toe, the patient of serious symptom is whole Sole all can rubescent, decortication, scratching often causes skin diabrosis cracking between toe, swelling pain the heaviest foot odor taste of generation, Have a strong impact on daily life and the work of patient.Tinea pedis is illustrative herein, not carries out protection scope of the present invention Limit.

100 example cases are out-patient, male 50 example, women 50 example；Age 10-70 year, average 30 years old；The course of disease 1 The moon～8 years.Some is developed to hands (becoming tinea manus and pedis), even whole body many places and tinea stove occurs.

Use the spray of preparation in embodiment 1 to be sprayed on affected part, be as the criterion with the skin in uniform fold affected part.Every day sprays two Secondary, using continuously one week is a course for the treatment of, takes effect the general same day, and after the course for the treatment of, pruritis disappears substantially, affected part band mycoderma Skin gradually necrosis comes off, and unaffected without mycoderma skin.Owing to causing the fungus of tinea pedis to have residual at footgear of patient etc., Therefore after disabling medicine, again can re-infection.So, after a course for the treatment of, 2-3 the course for the treatment of should be continuing with, effect just can be more longlasting. Can also discontinuously use, only use when again infecting, will not develop immunity to drugs.

Efficacy assessment standard: cure: without pruritus, the disappearance of pimple, vesicle, affected part skin gradually necrosis of carrying disease germs comes off, foot odor Gradually alleviate or disappear；Invalid: the still tinea pedis symptom such as pruritus.

The most on inspection, whole 100 example patients all meet the standard of healing after carrying out treating 1 course for the treatment of.

Untoward reaction: patient does not occurs untoward reaction over the course for the treatment of.

Experimental example 2

The tinea manuum, also known as fungal infection of hand and foot, is the mycosis of hand.Men and women, old and young all can fall ill, but the most common with person between twenty and fifty, many Send out in the centre of the palm and finger.Its skin common vesicle in summer or rotten to the corn sepage, show as squama and being dried winter and chap.Most Patient due to treatment not thoroughly or recurrent exerbation, can make the course of disease extend, not heal, so that pachylosis or chap.The tinea manuum exists It is illustrative herein, not protection scope of the present invention is limited.

60 example cases are out-patient, male 30 example, women 30 example；Age 25-60 year, average 38 years old；The course of disease 1 month ～18 years.Spring and summer common vesicle in season, erosion or xerosis cutis are coarse, the autumn and winter show as squama and be dried chap.

Use the spray of preparation in embodiment 2 to be sprayed on affected part, be as the criterion with the skin in uniform fold affected part.Every day sprays two Secondary, using continuously two weeks is a course for the treatment of, and after general 2 days, pruritus substantially alleviates, coarse alleviation, after the course for the treatment of, and pruritis Basic disappearing, the affected part scaling of skin that carries disease germs comes off, and skin gradually recovers one's health.More than many patient's several years, fungus Invade relatively deep, cause pachylosis and thicken, even invade in fingernail.So, to thoroughly cure, several treatment should be used continuously Journey.

Efficacy assessment standard: cure: without pruritus, affected part skin gradually necrosis of carrying disease germs comes off, and skin gradually recovers one's health；Nothing Effect: still pruritus, pachylosis symptom does not alleviates.

The most on inspection, whole 60 example patients all meet the standard of healing after carrying out treating 2-3 the course for the treatment of.

Claims

1. it is used for treating a dermopathic compositions, it is characterized in that: include the medicine of following weight portion: Radix Sophorae Flavescentis 1-1.5 part, flower Green pepper 1-1.5 part, Cortex Dictamni 1-1.5 part, Cortex Phellodendri 1-1.5 part, Fructus Kochiae 1-1.5 part, Fructus Cnidii 1-1.5 part, Fructus Xanthii 1-1.5 Part, Caulis Lonicerae 1-1.5 part, Radix Et Rhizoma Rhei 1-1.5 part, Cortex Meliae 0.5-1 part, pharmaceutically acceptable Aloe fresh goods 15-25 part and allantoin 0.18 ～2.5 parts.

The most according to claim 1 for treating dermopathic compositions, it is characterized in that: described pharmaceutically acceptable Aloe is that storehouse is drawn Rope Aloe, Aloe arborescens var. natalensis, Aloe vera L.var. chinensis(Haw.)Berg., aloe ferrox or A.saponaria.

The most according to claim 1 for treating dermopathic compositions, it is characterized in that: described compositions is external preparation Type.

The most according to claim 3 for treating dermopathic compositions, it is characterized in that: described exterior-applied formulation be solution, Spray, lotion, tincture, cream, unguentum, paste or powder.

The most according to claim 3 for treating dermopathic compositions, it is characterized in that: described exterior-applied formulation is spray.

The most according to claim 4 for treating dermopathic compositions, it is characterized in that: described constituent also includes water 180～280 parts, glacial acetic acid 1.8～8.4 parts and stabilizer 1.8～2.8 parts.

The most according to claim 6 for treating dermopathic compositions, it is characterized in that: described stabilizer is polyethylene pyrrole Pyrrolidone, gellan gum, ceteareth-20, xanthan gum or carbomer.

8. the preparation method for treating dermopathic compositions as described in as arbitrary in claim 5～7, is characterized in that: Comprising the following steps, following component is counted by weight:

1) weigh above-mentioned front ten kinds of medical material components by weight, immerse 50～70 DEG C containing 90～140 parts of water and 0.9～4.2 part In the solution of glacial acetic acid 1～2h, add stabilizer 0.9～1.4 parts, heated and boiled 5min, add the pharmaceutically acceptable reed smashed to pieces afterwards Luxuriant growth fresh goods 7.5～12.5 parts, continue heated and boiled 5min, is incubated 5～20min, separates to obtain liquid A and medicine residue；

2) thing residue of getting it filled adds and 90～140 parts of boiled water, and adds stabilizer 0.9～1.4 parts and glacial acetic acid 0.9～4.2 parts, The post-heating that stirs boils 5min, adds 7.5～12.5 parts of pharmaceutically acceptable Aloe fresh goods smashed to pieces afterwards, continues heated and boiled 5min, is incubated 5～20min, separates to obtain liquid B and medicine residue；

3) take liquid A and liquid B mix homogeneously, addition allantoin 0.18～2.5 parts, after naturally placing 1～3 day, be centrifuged off Precipitation, the supernatant of gained is this product.

Preparation method for treating dermopathic compositions the most according to claim 8, is characterized in that: described centrifugal ginseng Number is 5000～10000r/min, and the time is 5～10min.

Preparation method for treating dermopathic compositions the most according to claim 8, is characterized in that: described step 1) the pharmaceutically acceptable Aloe in is Aloe vulgaris, Aloe arborescens var. natalensis, Aloe vera L.var. chinensis(Haw.)Berg., aloe ferrox or A.saponaria.