CN106138494A - Kidney nourishing formula and production method thereof - Google Patents
Kidney nourishing formula and production method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations and production methods thereof. In particular to a traditional Chinese medicine compound preparation for treating chronic kidney diseases, which is prepared by six medicinal materials of astragalus root, rehmannia root, common macrocarpium fruit, cattail pollen, leech and scorpion and proper medicinal auxiliary materials. The He Shi Kidney nourishing prescription has the effects of regulating and tonifying spleen and kidney, and removing blood stasis and dredging collaterals. The early intervention treatment of Chronic Kidney Disease (CKD) has obvious curative effect in the aspects of protecting the function of kidney, delaying the time of entering the kidney for replacement, relieving the clinical symptoms of patients, improving the life quality of the patients and the like.
Description
Technical field
The invention belongs to Chinese medicine preparation and production method technical field thereof.Specifically use the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, a kind of compound Chinese medicinal preparation treating chronic renal disease made with suitable pharmaceutic adjuvant, there is tune spleen reinforcing kidney, effect of disperse blood stasis and dredge collateral.He Shi supports kidney side's therapeutic intervention as early as possible for chronic kidney disease (CKD), protection renal function, postpone enter kidney and substitute time, reduction of patient clinical symptoms, improve the aspects such as its quality of life there is significant curative effect.
Background technology
Chronic kidney disease (CKD) is an important public health problem, and the prognosis improving Patients with Chronic Kidney Disease needs the whole world to make joint efforts.The chronic renal disease that a variety of causes causes finally can develop into end stagerenaldisease.Although the success of renal replacement therapies method extends the life of a large amount of patient, but huge medical expense is still the heavy financial burden of family and society.Chronic renal insufficiency is divided into 4 stages by China always: i.e. renal function compensatory phase, renal function Decompensated stage, renal failure stage and Uremic.But, this renal function situation being unfavorable for evaluating patient, the early stage of patient is paid close attention to not.During AKF (NKF) was delivered in 2002, " monitoring of chronic renal disease progress and guideline of prevention and treatment " (kidney disease outcome quality initiative, K/DOQI) proposes " CKD (chronic kidney disease) " concept.By clearly proposing the definition of chronic kidney disease, estimating its incidence rate, could identify the commitment of chronic kidney disease, prediction risk factor, early discovery also treats high-risk group, reaches to improve nephropathy prognosis, the basic goal of raising life in patients.
" the China's chronic kidney disease Epidemiological study " that Wang Haiyan takes the lead, is published on Lancet and publishes for 2012, and it shows: " China's chronic kidney disease prevalence is 10.8%, thus estimates there are 1.2 hundred million Patients with Chronic Kidney Diseases in Chinese Adult ".Within 2010, the whole world has risen to 1 trillion dollars for the medical expense of ESRD, is therefore referred to as " most disease of spending ".According to incompletely statistics, China's every example hemodialysis patients year health care costs about 100,000 yuan, the average annual medical expense of peritoneal dialysis about 80,000 yuan；China's dialysis patient sum in 2013 is more than 300,000 people, and this accounts for and needs the 10% of dialysis patient sum.At present, the annual expense for dialysis treatment breaks through 30,000,000,000, if all ESRD patients all can accept dialysis treatment, its consuming will exceed the 50% of national health total expenditure, and such huge consumption is all heavy burden for the whole society.And along with population hypertension, the increase of diabetes prevalence, its renal complication caused, chronic kidney disease is made to present obvious ascendant trend, dialysis for these patients is paid about 240,000,000,000 yuans by China every year, and this will be society, government, the huge burden of individual and ever-increasing economic pressures.
Healthy and nutritional survey report (NHANESIII) the data of U.S.'s Third National show, CKD1-5 phase patient percentage ratio shared by general population is respectively as follows: 3.3%, 3.0%, 4.3%, 0.2% and 0.2%.The 1-3 phase proportion overwhelming majority.Research shows, CKD patient morbidity is higher 100 times than the sickness rate of end renal failure eventually in early days, if carried out early intervention, treatment, controls risk factor, CKD can be delayed to be in progress, even reduce ESRD sickness rate.Therefore the emphasis that international renal disease educational circles pays close attention to jointly in recent years is moved forward to hidden danger chronic kidney disease huge below it by chronic renal failure and replacement therapy thereof.But in China, the preventing and controlling for this huge hidden danger are the weakest.
Currently, doctor trained in Western medicine is kept on a diet for the treatment mainly formulation of CKD, reduces urine protein, is controlled the various clinical treatment guidelines such as blood pressure, anemia, regulation blood fat, regulation alcium and phosphor metabolization, regulation electrolyte disturbance and be widely used in clinic, effectively enriches the treatment means of chronic kidney disease.Medicine is concentrated mainly on hormone, immunosuppressant, angiotensin-convertion enzyme inhibitor (ACE I), angiotensin receptor blocker (ARB) etc., thus reach to delay the progress of CKD, but yet suffer from the problems such as renal failure progression rates controls less effective, renal failure important risk factor such as albuminuria lacks effective control device, ESRD patient's social aiding aged rate is relatively low.
Chinese medicine is in the Primary Care such as Diet Therapy and anti symptom treatment, CKD treatment field had unique advantage, clinical practice also demonstrates that Chinese medicine all obtains good efficacy to improvement, the raising of quality of life of Patients with Chronic Kidney Disease clinical symptoms, and it cheap, side effect is low, curative effect is comprehensive and non-invasive, advantage has obtained approving the most widely and paying attention to.Current clinic is usually used in treating the Chinese patent medicine of CKD NIAODUQING KELI, Huang Kui capsule, paecilomyces hepiall chen, Caps Bailing, SHENSHUAINING capsule etc., middles and advanced stage of focusing on are treated more, pay close attention to early metaphase treatment less, simple emphasis the kidney invigorating or heat-clearing and toxic substances removing diuresis, few spleen kidney giving young employees remedial-courses in general knowledge and vocational skills disperse blood stasis and dredge collateral simultaneously, though solving partial clinical problem, but the needs of clinic can not be met far away.
Each family Couple herbs to chronic kidney disease: Shao Chaodi treatment CKD emphasizes to balance internal organs negative and positive, cold and heat are biased for balance, equilibrium water liquid comes in and goes out, and is good at using Dihuang Wan class preparation coordinating YIN and YANG to make basis, with cardization sanction.Chen Yi-ping is thought at CRF azotemia phase, and symptom is hidden.Emphasize in treatment that benefiting QI for activating blood circulation is main, be aided with removing dampness rush down turbid ruling by law treat early, CRF in mid-term, medicinal Astragalis, Radix Angelicae Sinensis, Caulis Spatholobi, Rhizoma Polygonati, pale art, Radix Codonopsis, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Radix et Rhizoma Rhei (processed) etc., be developed to Uremic, then healthy energy is the most empty, and noxious dampness is jammed three burnt.Control when the kidney warming detoxifies, unclog and readjust three Jiao, medicinal gun additioner, the Rhizoma Pinelliae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Folium Perillae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Serissa foetida, testa mungo, Fructus Amomi, Rhizoma Zingiberis Recens etc..Opening fine jade used for three phases dialectical, emphasized particularly on different fields.CRF early treatment's strengthening spleen, tonifying kidney is crucial；CRF intermediate period treatment payes attention to reinforcing and reducing concurrently, and conventional rightingization is turbid invigorates blood circulation；CRF treatment of late stage focuses on lets out turbid removing toxic substances, turns round and look at and protects gastric qi, and uses multipath medication.Tu Liyin thinks that the CKD initial stage includes that spleen kidney qi yang deficiency, the spleen kidney qi deficiency of YIN, the hepatic and renal YIN deficiency and negative and positive of qi and blood are the most empty, controls respectively and closes gas ball with Liujunzi Tang, Shenqi Dihuang Decoction closes that big complement is decocted, Lycium-rehmannia soup closes TIANMA GOUTENG YIN plus-minus, GUIPI TANG etc.；Pathological changes Rhizoma Coptidis WEIDANTANG, the wenpi decoction selected to folder turbid damp person in mid-term, folder the wet person of water then subtract with WULING SAN, WUPI YIN, Wei Ling Tonga more；Pathological changes later stage spleen kidney more loses, and the turbid obstruction of the stasis of blood is even more serious, and various crisis easily occur, and follows the principle of " take stopgap measures time anxious, relieving the primary symptom in a chronic case ", Symptomatic medicine during treatment.Tao Xing etc. propose to apply " change ", " row ", " OK ", " solution " to treat for the turbid poison of CKD, to turn to main person, add the plus-minus such as Fuling Decoction, Pingwei San with Rhizoma Coptidis WEIDANTANG, the little Rhizoma Pinelliae；Being main person with row, " diaphoresis " is added and subtracted with Mahuang Lianqiao Chixiaodou Tang, and " promoting diuresis to alleviate water retention " can diuresis be arranged turbid, and the conventional plus-minus such as WULING SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, two can let out turbid by purging FU-organs, and the informal dress Chinese herbs decoction containing Radix Et Rhizoma Rhei is let out turbid with purging FU-organs；Dissipating with row is main person, adds and subtracts with decoction for removing blood stasis, Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae etc.；It is main person with removing toxic substances, adds and subtracts with Radix Et Rhizoma Rhei, Herba Taraxaci, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Pseudobulbus Cremastrae Seu Pleiones etc. with Rhizoma Coptidis toxic materials clearing away decoction.Ye Jinghua in the CKD disease progression phase based on liyan jiedu, thoroughly through reaching network.Is divided into 2 types: 1. spleen-kidney deficiency, turbid damp accumulation type the state of an illness stage of stable development, controls suitable Yishen Jianpi；2. hyperactivity of YANG due to deficiency of YIN, ecchymosis accumulate resistance type, control suitable nourishing YIN and clearing away heat, suppressing the hyperactive liver and subsiding YANG, and eliminating toxic substances to remove stasis of holding concurrently lets out turbid dampness removing.He Shi finds from clinical observation, and syndrome of blood stasis accounts for 67.5% in chronic kidney disease, and each course of disease stage occurs.From intending " Kangqianling Granules ", being made up of Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Semen Persicae, Radix Et Rhizoma Rhei etc., verify through clinical research, total effective rate is 89.55%.Sun Shi etc. carry out Clinical controlled trial, wet blood stasis syndrome patient's random packet of 60 examples CKD (2-3 phase) being suffered from a deficiency of the kidney, the clinical efficacy of research " tonifying speen and tonifying kidney blood circulation promoting recipe ".Experimental group compares with matched group, and " tonifying speen and tonifying kidney blood circulation promoting recipe " wet blood stasis syndrome of suffering from a deficiency of the kidney CKD (2-3 phase) patient is evident in efficacy." tonifying speen and tonifying kidney blood circulation promoting recipe " forms: SHENGHUANG cyclopentadienyl 30g, each 15g of Radix Codonopsis, Radix Angelicae Sinensis (parched), each 12g of Radix Achyranthis Bidentatae, the Radix Rehmanniae, each 10g of the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, CHUANSHAO, Radix et Rhizoma Rhei (processed) 6g, and with card plus-minus.Zhang Shi etc. use tonifying speen and tonifying kidney, Activating profit method that CKD3 phase patient is carried out clinical observation on the therapeutic effect, and matched group gives doctor trained in Western medicine Primary Care；Treatment group adds with tonifying speen and tonifying kidney, the treatment of Activating profit side.Treatment group total effective rate 83.3%, obvious compared with matched group curative effect.Tonifying speen and tonifying kidney, Activating niche we: Radix Astragali 30g, Radix Codonopsis (parched) 15g, Radix Dipsaci 15g, Semen Cuscutae 15g, Radix Salviae Miltiorrhizae 10g, RADIX CURCUMAE 10g, Rhizoma Smilacis Glabrae 30g, Radix et Rhizoma Rhei (processed) 10g, Herba Hedyotidis Diffusae 30g, and with card plus-minus.Xie Zhihua etc. delay the research of CRF curative effect by NIAODUQING grain, result display NIAODUQING KELI can by reducing urine protein and discharging, regulation blood fat, reduce the number of ways such as creatinine, blood urea nitrogen and delay the progress of CRF.Bright pretty grade of state treats CRF patient in early days from quasi-complement kidney benefit unit side (Fructus Corni, Radix Polygoni Multiflori Preparata, Rhizoma Polygonati, Fructus Lycii, the Radix Astragali, Radix Codonopsis, Radix Rehmanniae Preparata, Radix Aconiti Lateralis Preparata, Rhizoma Dioscoreae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi), compares with matched group oral administered compound α mono-keto acid sheet.After two groups of drug withdrawals 1 month, serum creatinine measured value compares, and treatment group is significantly lower than matched group.
The academic thought of what generation east distinguished veteran doctors of TCM treatment chronic kidney disease: He Shidong teaches, director Chinese physician, Master degree candidate tutor, within 2012, national distinguished veteran doctors of TCM medicine expert passes on operating room construction project expert, the 3rd crowd of old docter of TCM medicine expert Academic Experience inheritance work counselor in the whole nation, obtains " Guangdong Province's famous physician " title for 2012, is engaged in internal medicine clinic, 40 over-carriages are taken up a job as a doctor in scientific research, teaching, being familiar with Qi Huangzhi road, the treatment to chronic kidney disease has rich experience.What is thought always, and chronic kidney disease belongs to difficulty severe disease, needs long-term defence, only grasps its core pathogenesis, just will not be the most square because curative effect in short-term is aobvious.Can not content just to " have is that card is with being medicine ", if failing to grip with core pathogenesis, clinic also can be sayed with regard to inefficacy.Wherein chronic kidney disease early metaphase (1-3 phase) core pathogenesis is " deficiency of spleen and stomach, the kidney network stasis of blood are stagnant ", is basic method for the treatment of with " adjusting spleen reinforcing kidney, disperse blood stasis and dredge collateral ".
Understanding to " deficiency of spleen and stomach, kidney network stasis blocking " core pathogenesis: chronic kidney disease either pathogenesis etiology or clinical symptoms, sign, the most various complexity, faces necessary fully determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs during card, finds out Disease Essence, treatment of disease must aim at its pathogenesis.What is thought always: treatment must aim at the pathogenesis of disease should be originally in internal organs, and the clearest and the most definite pathological changes internal organs just can differentiate the root of disease.Kidney is the congenital foundation, and spleen is the foundation of acquired constitution, and the two is the most mutually subsidizing promotion, influences each other on pathology, occupies important function in the pathogenic pathogenesis of kidney disease." the spleen transporting the nutritious substance in the stomach person is also ", spleen transporting and transforming nutrients from foodstuff is precise and tiny normally, and body can moisten to support to absorb and perfect；Otherwise, " extremity must not report water essence derived from food, and gas day, sering was unfavorable to decline, and muscles and bones muscle all depletion of QI are with life ", wet stopping gathers water, and paddy essence does not follow Chang Jing, no resource of generating and transforming QI and blood, then turbid urine, asthenia, the disease of edema and give birth to.The kidney being a water ZANG-organ, main total body water liquid metabolism." Plain Questions " is said: " kidney person ... polywater and sick also." spleen sun rely kidney water to make moist, spleen-YANG being rooted in kidney-YANG, absolutely prove and once send out as nephropathy, disturbance in functioning of QI, accumulate in water turbid damp poison, taste moisten to support agitates unable, and strong fortune is biochemical too late, lifting hinge dereliction of duty, causes organismic internal environment disorderly, until renal failure, obstruction and rejection danger are waited." doctor door blow and shout to waken one from error " says: " energy the biochemistry person of taste, real by the inspiration of Yuanyang in kidney, and Yuanyang is with the closeest for expensive, itself thus can close person admittedly, rely again that taste biochemistry the moon is smart educates ear with culvert." therefore, what emphasizes when treating chronic kidney disease always: effects a permanent cure and must adjust spleen reinforcing kidney.Spleen kidney is double to be adjusted, and can promote the strong fortune of temper, promote that kidney qi is enriched, and essence in kidney obtains the precise and tiny of spleen transporting and supplements nutrition, and spleen transportation capabilities obtain the warm promotion of kidney yang, and body is just being so incensed that multiple, and pathogenic factor then goes.
" Plain Questions regulating menstruation opinion " has a speech: " road of the five internal organs all for through tunnel, congestion resistance network, vim and vigour get along well, and all kinds of diseases and ailments are change and give birth to ".Chronic renal disease delay with the passing of time generation QI-blood circulation is smooth and the mechanism of stasis is a lot, mainly has: the deficiency of vital energy can not promote blood operation to cause the stasis of blood；Kidney yang deficiency, cold from interior life, sun does not transport blood, and blood is met cold then solidifying and is the stasis of blood；Blood deficiency sering is not filled, and blood is dilatory, it is easy to stagnate into the stasis of blood；Essence not activating QI and change water, water retention then vapour lock, the stagnation of QI then blood stasis；Ill with the passing of time touching do not heal, deep and enter network, and cause venation block；The susceptible exopathogen because of empty, exopathogen invasion visitor, in meridians, makes venation get along well, and blood is puckery obstructed, and stasis becomes swollen；The deficiency of YIN is lit a fire, blood network of burning, or QI failing to control blood, outside blood oozing from the body openings or subcuta neous tissue arteries and veins, all can be stopped between internal organs and form the stasis of blood, and therefore nephropathy all has stagnation of blood and QI, runs the most smooth pathology."Nei Jing" cloud: " Sun Luoshui overflows, then have stagnant blood ".Zhou Xuehai cloud: " if blood network flexing, all there is the stasis of blood stagnant ".Glomerule is blood capillary ball, and its pathological changes is easily caused kidney network blood stasis, numbness hinders obstructed pathological changes.CKD can form glomerular sclerosis, extracellular matrix increases, kidney region fibrosis, renal tubules atrophy etc., ultimately form contracted kidney, all relevant with blood stasis.To chronic kidney disease pathogen usually intruding into collateral in protracted disease, the kidney network stasis of blood is stagnant, and numbness blocks water fortune blood, causes renal function degradation for a long time, therefore disperse blood stasis and dredge collateral method, seek medical advice from blood system, the treatment of chronic kidney disease has considerable meaning, often can run through whole therapeutic process.
He Shi supports the characteristic of kidney side: according to the property of medicine four natures and five flavors of drug when what faces card always, tunes spleen reinforcing kidney being implemented chronic kidney disease treatment all the time, reusing the Radix Astragali is monarch drug, sweet in the mouth, and slightly warm in nature returns liver, spleen, lung, kidney channel.Can ascending YANG and invigorating QI, strengthening superficial resistance to stop perspiration, detoxification evacuation of pus granulation promoting." Mingyi Bielu " carries it: " married woman's dirty ailment said due to cold or exposure gas of son, by stagnant blood between the five internal organs, mends husband deficient, and five kinds of over strain weakness and emaciation quenches the thirst, and stomachache lets out dysentery, QI invigorating, Li Yin gas." Li Shizhen (1518-1593 A.D.) is called " length of tonic ".Extensively application is with the treatment of chronic kidney disease, and treatment chronic kidney disease needs invigorating the spleen and replenishing QI replenishing essence, must use the Radix Astragali, taking the power of its QI invigorating qi-restoratives, residence has the tonic day after tomorrow to support congenital meaning, and the prosperous then biochemical function of spleen is vigorous, kidney is nourished very well, therefore has effect of well taking a tonic or nourishing food to build up one's health to kidney.Ministerial drug Radix Rehmanniae, Fructus Corni, enriching yin and nourishing kidney, and have the merit of heat clearing away concurrently, spleen kidney is mended altogether, takes the photograph sun Gui Yin, it is intended that emphasize successively two days.Adjuvant is Pollen Typhae, Scorpio, Hirudo.Pollen Typhae effect is blood circulation promoting and blood stasis dispelling, diuresis of stopping blooding.From Chinese Zhang Zhongjing " Medical Treasures of the Golden Chamber ", the generation discussing the diseases such as stasis of liver-Q and liver-blood, arthromyodynia, asthenia is relevant to the pathogenesis of channels silt resistance, and pioneering Houxuehuayu tongluo and worm ant search and pick dredging collateral method and take a hint, Drug Prepared from Insects is good at searching and is picked by heresy, the through sick institute of calming wind and dredging collateral, can deeply search carefully pick hiding in the heresy of interior wind-phlegm blood stasis.What appropriates Hirudo always with Scorpio is to medicine, the salty hardship of nature and flavor, function blood circulation and removing stasis dredging collateral.Full side plays tune spleen reinforcing kidney, the merit of disperse blood stasis and dredge collateral altogether.
He Shi supports kidney side and production method is to use the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, and the He Shi made with suitable pharmaceutic adjuvant supports kidney side's oral liquid, granule, capsule, pill and tablet.Early intervention for chronic kidney disease (CKD) is treated, protection renal function, postpone enter kidney and substitute time, reduction of patient clinical symptoms, improve the aspects such as its quality of life there is significant curative effect.
In January, 2012 is to during in December, 2013, to 64 example Chinese medical discriminations it is that deficiency of spleen and stomach, the kidney network stasis of blood be stagnant and CKD CKD patient for the 1-3 phase by stages gives He Shi and supports kidney reef knot and close Primary Care and treat continuously more than 6 months, carry out observing in terms of clinical total effects, the change of TCM syndrome integration, physico-chemical examination index etc. respectively evaluating.Result shows: He Shi supports the conjunction Primary Care of kidney reef knot can substantially reduce patient's serum creatinine, 24 hours Proteinuria level, improves clinical symptoms, is effectively improved renal function, and curative effect is better than Routine control group.By evaluation of clinical curative effect, Chinese drug-treated group totall effective rate in clinical treatment and matched group no significant difference, show its effect treatment no less than the ACEI renal function protecting generally acknowledged.Conclusion: He Shi supports the conjunction Primary Care of kidney reef knot can be effectively improved CKD1-3 phase deficiency of spleen and stomach, the clinical symptoms of the kidney network stasis of blood stagnant card patient, improves renal function, delays the progress of the state of an illness.
Through retrieval Gazette of Patent for Invention and documents and materials, currently without using the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, the He Shi made with suitable pharmaceutic adjuvant supports kidney side's Chinese medicine preparation.
Summary of the invention
The present invention is to provide a kind of oral preparation of Chinese traditional medicinal treating chronic kidney disease.Early intervention for chronic kidney disease (CKD) is treated, protection renal function, postpone enter kidney and substitute time, reduction of patient clinical symptoms, improve the aspects such as its quality of life there is significant curative effect.
1, goal of the invention
An object of the present invention: one of cipher prescription of He Shi Yang Shenfangshi Dongguan Hospital of TCM chronic kidney disease treatment; it is to take up a job as a doctor 40 over-carriages in famous physician what generation east in Guangdong Province's; through the treatment theory of chronic kidney disease, the summary of experience and clinical practice are arisen; sincerely keep the pathogenesis of " deficiency of spleen and stomach, the kidney network stasis of blood are stagnant "; the method for the treatment of of " adjusting spleen reinforcing kidney; disperse blood stasis and dredge collateral " is proposed; therapeutic intervention as early as possible, protection renal function, postpone enter kidney and substitute time, reduction of patient clinical symptoms, improve the aspects such as its quality of life and have significant curative effect.What old experience is inherited in order to sum up; in order to preferably provide convenient, economic help to patient; the highest more preferable social benefit is brought, it is provided that a kind of effective ingredient is clear and definite, safety is high, untoward reaction is little, the Chinese medicine preparation of determined curative effect carrys out effective renal function protecting to society.He Shi supports the early intervention treatment for chronic kidney disease of the kidney side, abundant and Developing TCM treats chronic kidney disease, widen Chinese Traditional Medicine and treat the bright prospects of great chronic disease, the abundantest clinician treats the means of chronic kidney disease, has practical value and great social meaning widely.
The two of the purpose of the present invention: be to provide a kind of taking convenience, determined curative effect, for treating the oral preparation of Chinese traditional medicinal of chronic renal disease, to overcome the defect in existing product field.
The three of the purpose of the present invention: being to provide a kind of by the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, the He Shi made with suitable pharmaceutic adjuvant supports kidney side and production method thereof.
2, technical scheme
He Shi supports kidney side and production method is theoretical as foundation with modern Chinese medicine, application motherland traditional medicine, modern medicine and technology of pharmaceutical engineering, choose and meet the Radix Astragali of quality criteria requirements, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material and pharmaceutic adjuvant under " Chinese Pharmacopoeia " and country relevant laws and regulations, continuous item, use a kind of oral preparation of Chinese traditional medicinal new product that Modern preparations manufacturing technique method develops.
It is by the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material that He Shi supports kidney square opening formulation, and the He Shi made with suitable pharmaceutic adjuvant supports kidney side's oral liquid, granule, capsule, pill and tablet.
The Radix Astragali: for leguminous plant Radix Astagali [Astragalus membranaceus (Fisch.) Bge.Var.mongholicus (Bge.) Hsiao] or the dry root of Radix Astragali [Astragalus membranaceus (Fisch.) Bge.].Head is loaded in Shennong's Herbal, and sweet in the mouth is warm in nature, has the effects such as tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, detoxification evacuation of pus, inducing diuresis to remove edema and granulation promoting.
Many effects of the Radix Astragali, all come from the merit of its QI invigorating, therefore have again the laudatory title of " all medicines of QI invigorating ".Research is thought, the basic pathogenesis of chronic kidney disease can be summarized as the wet stasis of blood of suffering from a deficiency of the kidney, and suffering from a deficiency of the kidney is the basis of chronic kidney disease, and safeguards that kidney qi is one of basic therapy of chronic kidney disease, and the Radix Astragali, as the panacea of QI invigorating, has important effect in treatment nephropathy.
The chemical composition of the Radix Astragali mainly contains astragalus polysaccharides, saponin, flavone and several amino acids, vitamin and trace element, participates in the multiple metabolism of body.There is heart tonifying, blood pressure lowering, myocardial preservation, removing free radical, reduce lipid peroxidation, suppress platelet aggregation, improve the pharmacological actions widely such as microcirculation, anti-hypoxia, immunomodulating.The Radix Astragali, rich in effective ingredient such as trace element-selenium and flavone, saponin, polysaccharide, is to participate in removing free radical, antioxidative important substance.
The protective effect pharmacological evaluation of renal function is proved; the Radix Astragali can delay glomerular sclerosis; increase glomerular filtration rate and kidney perfusion amount; improve the oxidative stress status in rat body, by increasing nephridial tissue NO level, reduce oxygen-derived free radicals; inhibited apoptosis and alleviate renal ischemic Tissue reperfusion injury; can also increase by blood serum induced hepatocyte growth factor growing amount, alleviate kidney injury, be finally reached the purpose improving renal function.
Research shows, the Radix Astragali can improve renal glomerular disease protein metabolism disorder, improves blood plasma albumin level, reduces urine albumen amount；Its effect for reducing fat can prevent and treat glomerular sclerosis effectively；Also can reduce blood glucose, prevent and treat diabetic renal damage；The most capable of inhibiting cell adhesion molecule 1 (ICAM-1) is expressed, thus plays a protective role in renal ischemic reperfusion injury.Research shows, the Radix Astragali can be by regulation IgA nephropathy rat model Th1、Th2Balance disorders, thus improve Th type cytokines interleukin-4 (IL-4) and the level of tumor necrosis factor γ (INF-γ) in serum, and reduce Th in nephridial tissue2Type cytokines TGF-β1With the expression of t cell growth factor (IL-5), delay the progress of IgA nephropathy.
Research shows; the Radix Astragali has resistance inhibitor action to renal failure; ischemic kidney had protective effect; the effect such as antioxidation, removing free radical, promotion cellular metabolism, inducing diuresis to remove edema, minimizing urinary albumin excretion, rush liver synthesis albumin, blood fat reducing, regulation immunity, blood pressure lowering, to protect kidney cell to escape injury.Damaging as the patient of main pathogenesis, when selecting tonic, the most reusable Radix Astragali to dialectical suffer from a deficiency of the kidney for spleen lung, the Radix Astragali can the dirty gas of spleen reinforcing lung kidney three.Modern study also confirms: the Radix Astragali can by improve blood plasma albumin level, regulating lipid metabolism, promotion water sodium excretion, improve hypercoagulability, alleviate injury of kidney, renal function protecting etc. effect treat CKD.Research shows, the Radix Astragali has anti-peroxidation, regulation Endothelin and nitric oxide production balance, improves glomerular filtration function, improves the effect such as platelet function, anti-albumen nonenzymatic glycosylation, and water and sodium, protein and lipid metabolism can be improved, immune system can also be regulated, affect hemorheology, suppression inflammatory factor, reduces the effects such as fiber generation, all has certain curative effect for multiple kidney diseases such as diabetic nephropathy, the nephrotic syndrome, chronic nephritis, acute or chronic renal failures.The Radix Astragali has many effects, has important effect, be widely used to multiple kidney disease in the treatment field of nephropathy.
Radix Rehmanniae: head sees Shennong's Herbal, belongs to top grade.After the Song dynasty, begin with raw ripe dividing.Radix Rehmanniae i.e. Radix Rehmanniae, sweetness and bitterness and tremble with fear, can clearing away heat and cooling blood, again can YIN nourishing and the production of body fluid promoting.It is usually used in heat and enters the fever of the body of nutrient blood, dry hot-tempered, macule, or heat in blood is hemorrhage and the xerostomia red tongue etc. of YIN damaged by pathogenic heat.The Shennong's Herbal relatively early detail function of this product.Famous doctor's Zhang Zhongjing Radix Rehmanniae compatibility other drug, treatment insufficiency of kidney-YANG etc..Ancestral side's BAWEI SHENQQI WAN of the kidney invigorating formulated in " Medical Treasures of the Golden Chamber ", it is adaptable to all diseases of insufficiency of kidney-YANG.Jin and Yuan dynasty, respectively sends doctor's also many optionally yellow prescriptions, is widely used in the diseases such as deficiency of kidney yin.There is evaluation to say: Radix Rehmanniae, be the key medicine of the kidney invigorating man, tonifying YIN blood top grade.
At present, the clinical practice of Radix Rehmanniae is the most increasingly extensive, and some the ancient prescription range of application based on Radix Rehmanniae is also progressively expanding.Deficiency of kidney-YIN person in the multiple chronic disease processes such as hypertension, diabetes, diabetes insipidus, chronic nephritis and gynecological, department of pediatrics, ophthalmology, department of eye it is usually used in such as LIUWEI DIHUANG WAN and plus-minus side thereof.
The protective effect of kidney is already proven by Radix Rehmanniae, and correlational study is further deeply in recent years.Rehmannia glutinosa Libosch Water extracting solution can substantially reduce mouse retention PE, improves the pathological changes such as glomerular epithelium cell podocytic process fusion.The prevention of Radix Rehmanniae extractum is administered 2h can effectively protect kidney mitochondrial breathing production capacity function, and in dosage dependence, illustrates that Radix Rehmanniae has obvious renal ischaemia protective effect.Finding the prescriptions such as application Radix Rehmanniae in facing card, treatment chronic nephritis has good therapeutic effect.
Fructus Corni: for the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Sour in the mouth, slightly warm in nature, Liver and kidney warp.It is the famous Chinese medicine of China, there is effect of liver and kidney tonifying and essence astringing and desertion stemming.The experience of the Compendium of Material Medica collection ancient Chinese medicine doctor application Fructus Corni of Ming Dynasty's Li Shizhen (1518-1593 A.D.), is classified as Fructus Corni controlling nocturnal emission with astringent drugs of enriching blood, liver and kidney tonifying, regulating QI, qi-restoratives, improving eyesight and the medicine kept fit.Research shows, Fructus Corni officinalis contains abundant nutrient substance and functional component, predominantly pentacyclic triterpene, iridoid, tannin and flavone and substantial amounts of volatile material and saccharide etc., the most also has the important medical values such as antibacterial, immunomodulating, blood sugar lowering, antioxidation, heart tonifying and shock.
The Fructus Corni hydrotrope has protection and improves effect of insufficiency of kidney-YANG animal model liver function.The kidney invigorating medicine Fructus Corni water solublity total extract, can protect the pathomorphology of the organs such as liver caused by 17-hydroxy-11-dehydrocorticosterone, adrenal gland, testis and histochemistry to change, reduce animal pattern mortality rate.Point out this medicine syndrome of deficiency of kidney-YANG to deficiency of YIN affecting YANG, have more significant tonification kidney yang effect.The kidney-replenishing effect of this medicine, is not hormone replacement therapy, but realized by body self regulatory function.It can recover animal immune level, it may be possible to one of mechanism of himself regulation.
Pollen Typhae: Chinese medicine Pollen Typhae system Typhaceae (Typhaceae) typha plant Typha angustifolia Herba Typhae (Typha angustifoliaL.), typha orientalis (T.orien-talis.Preal) or the dry pollen of congener.Begin to be loaded in Shennong's Herbal, be classified as top grade.Pollen Typhae dries rear rolloff, and life is used or parch to black use, is mainly used in pain relieving, hemostasis etc..After it is concocted, medicinal head is loaded in " Japan hanako materia medica ", and its flat sweet in the mouth of property returns liver, pericardium channel, has hemostasis, analgesia, blood stasis dispelling, the effect such as treating stranguria.Pollen Typhae contains multiple chemical composition, mainly includes flavonoid, steroid, alkanes and saccharide etc..
Modern pharmacology research shows, Pollen Typhae water extract-alcohol precipitation liquid has and improves microcirculation, improves internal cAMP level, prevents and treats the multiple pharmacological effect such as coronary heart disease and myocardial infarction.Research shows, Cr, BUN concentration in deformity erythrocyte, 24h urine protein quantitation and serum in urine and urine all can be allowed to reduce by Pollen Tyjphae extract, and Pollen Typhae high dose group is substantially better than carbazochrome salicylate group and saline control group (P ＜ 0.05).Pollen Tyjphae extract can reduce the hematuria of nephritis hematuria rat model, albuminuria symptom, improves renal function indices, optimal with high dose group action effect.Pollen Typhae has protective effect to renal function, and its mechanism of action is the content by stimulating or increase internal SOD, eliminates interior free yl.
Hirudo: for annelid Hirudinidae Hirudo, Hirudo or the dry body of Folium Salicis Babylonicae Hirudo.Its acrid in the mouth is salty, property is put down, and has the effect such as removing blood stasis, dredge the meridian passage." Bencao Congxin " carries Hirudo " harness the river swollen, relieve internal heat ".Hirudo is especially prominent in terms of blood circulation promoting and blood stasis dispelling, and its property is apt to removing blood stasis blood, and removing blood stasis abdominal mass is gathered, the meridian dredging diuresis, and stopping caused edema in treatment blood stasis has good curative effect.Modern age, doctor's Zhang Xichun praised that Hirudo was " merit row first in stasis-breaking drug " " a removing blood stasis with potent drugs blood and do not break fresh blood ".Shennong's Herbal is recorded the Hirudo treatment to multiple disease, has called its " main by stagnant blood, blood stasis, to close by the moon, removing blood stasis, loss of fecundity, dredging water passages ".
Effective bioactive extracts hirudin (hirudin) of Hirudo is natural Thrombin specificity inhibitive factor, plasma protein can be improved, reduce Fibrinogen, platelet aggregation rate and urine N-acetyl-β-D aminoglucose carbohydrase, thus realize anticoagulant, thrombolytic, reduction blood viscosity, raise blood 6-ketone-PGF1 αAnd reduction thromboxance B2Deng effect.Hirudin is the effect by suppressing inflammatory mediator thrombin, suppression MC hypertrophy and anti-ECM accumulation, thus reaches to resist the effect of glomerular sclerosis.
Another histamine's material that Hirudo contains, has expansion blood capillary, antiinflammatory, the hemodynamic effect of improvement, has increase peripheral blood flow, improves ischemia and antiplatelet aggregative activity.Research finds the deposition of FRA, FN content and the glomerular sclerosis of glomerule are notable positive correlation.Hirudo can reduce deposition and the content of FN of FRA, effectively alleviates glomerular sclerosis.The pharmacological action of Hirudo shows in the aspect of anticoagulant, antithrombotic, antiinflammatory and blood fat reducing the most mostly, modern pharmacological research confirms, the pharmacological action of Hirudo can reduce the stickiness of blood plasma, improve hemorheology, can also significantly reduce creatinine, blood urea nitrogen simultaneously, the excretion rate of urine protein can also be reduced, it is applicable to the cards such as chronic glomerulonephritis, nephrotic syndrome and renal insufficiency, high coagulation, fall albumen can be improved, reduce blood fat and blood viscosity, prevent the fibrosis of renal interstitial, delay renal function the most complete.
Research in recent years shows, Hirudo and preparation thereof have the specially good effect improving renal function.Use Hirudo treatment chronic kidney disease more and more extensive clinically.In recent years, Hirudo single medicinal material, compound recipe or hirudin gradually at clinical expansion, obtain significant curative effect for chronic renal disease.Its principle active component is hirudin, has anticoagulant, antithrombotic, effect for reducing blood fat, and can reduce whole blood and blood plasma stickiness, improves hemorheology, can significantly reduce serum creatinine, blood urea nitrogen simultaneously and reduce Urinary Albumin Excretion.
Radix Astragali Leech capsule has strengthening spleen, tonifying kidney, the function of turbid toxin expelling is let out in heat clearing away, eliminating evil develops simultaneously with righting.Radix Astragali QI invigorating qi-restoratives in side, has swelling diuretic, the effect of regulation immunologic function；Hirudo blood circulation promoting and blood stasis dispelling, removing blood stasis and just do not hinder, the hypercoagulability in microcirculation and nephrotic's body can be improved, have enhancing tubular excretion, reduce platelet aggregation, anticoagulation, the effect of promotion repair of damaged tissues.
In a word, Hirudo applies to the treatment of chronic kidney disease the most widely, its mechanism of action is mainly reflected in: suppression platelet aggregation, anticoagulation, activation fibrinolytic system, thrombus, reduce blood lipid level, improve hemorheology, anti-kidney region fibrosis, alleviates the inflammatory reaction damage to nephridial tissue, anti-proliferation of glomerular mesangial cells and inflammatory cell infiltration etc..
Scorpio: for the dry entirety of Arthropoda Arachnoidea Buthidae animal Scorpio.There is effect of endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain, faint the diseases such as wind, palsy facial paralysis, tetanic spasm, sore swollen toxin, scrofula tuberculosis, intractable migraine and general headache, rheumatic arthralgia for anxious intermittent infantile convulsion.Scorpio scorpion venom is as principle active component.Nephrectasia blood capillary, alleviates Renal pathology.
Poison heresy is one of most important factor causing and increasing the weight of chronic kidney disease generation and development.The counteracting toxic substances effect of Scorpio is the most notable, and the upper respiratory tract infection merged for treatment chronic nephritis has good curative effect, and chronic kidney disease is associated with sore swollen toxin, scrofula scabies all can use it by compatibility.
Modern pharmaceutical research confirms, Scorpio has regulation immunity, anticoagulant, antiinflammatory, the effect of blood fat reducing, is applied the pathological change that can alleviate kidney in the treatment of nephropathy, eliminates partial immunity complex and strengthens absorbing.
After glomerular sclerosis, fibrosis occurs in chronic nephritis, Renal microcirculation obstacle, renal perfusion is not enough, causes damaging further.Research finds, Scorpio has improving micro_circulation effect.Scorpio contains the substantial amounts of thromboembolism factor (BDF), both can eliminate arteriosclerosis plaque, inhibition thrombosis, can penetrate again thrombosis film and thrombosis is resolved into fritter, be dissolved, and repairs Ink vessel transfusing epithelium simultaneously, recovers vascular smooth muscle elastic.Thus safeguard renal blood vessels function, improve Renal microcirculation, it is ensured that renal perfusion.
The object of the present invention is achieved like this:
A kind of He Shi supports kidney side and production method thereof, it is characterised in that: it is to be prepared from by Radix Astragali 10-60 part, Radix Rehmanniae 5-45 part, Fructus Corni 5-35 part, Pollen Typhae 1-30 part, Hirudo 1-10 part, the crude drug of weight portion of Scorpio 1-10 part.
The preferred weight range of above-mentioned raw materials medicine is: Radix Astragali 20-55 part, Radix Rehmanniae 10-35 part, Fructus Corni 15-30 part, Pollen Typhae 5-25 part, Hirudo 2-8 part, Scorpio 2-8 part.
A kind of He Shi supports kidney side and production method thereof, it is characterised in that: it is by the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, makes He Shi with suitable pharmaceutic adjuvant and support kidney side's oral liquid, granule, capsule, pill and tablet.
A kind of He Shi supports kidney side and preparation method thereof, it is characterised in that: He Shi is supported kidney side's medicinal substances extract, mixes with suitable pharmaceutic adjuvant, make the production process of oral liquid, granule, capsule, pill and tablet.
A kind of He Shi supports kidney side's oral liquid and production method thereof:
A kind of He Shi supports the production method of kidney side's oral liquid, it is characterised in that: being to use the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, the extract of Scorpio Six-element medical material, add correctives, preservative, add water adjustment；Through fill, sterilizing, check, the production technology such as packaging is prepared from.
A kind of He Shi supports kidney side's oral liquid and production method thereof, it is characterised in that: it is made up of the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medicinal substances extract, correctives, preservative and water.
He Shi is supported kidney formula extraction and suitable pharmaceutic adjuvant is made He Shi and supported kidney side's oral liquid, it is characterised in that: pharmaceutic adjuvant includes correctives, preservative.Correctives is one or more in simple syrup, stevioside, sodium cyclohexyl sulfamate, sucrose, LaspartylLphenylalanine methylester, acesulfame first.Preservative is one or more in parabens, benzoic acids, sorbic acid methyl ester, Oleum Caryophylli.
A kind of He Shi supports kidney side's granule, capsule, pill, tablet and production method thereof:
A kind of He Shi supports the production method of kidney side's granule, capsule, pill, tablet, it is characterised in that: when preparing granule or pill or capsule or tablet, pharmaceutic adjuvant used includes diluent, binding agent, lubricant.Diluent includes one or more in starch, lactose, sucrose, dextrin, hydroxypropyl methyl cellulose, pregelatinized Starch, microcrystalline Cellulose.Binding agent includes one or more in water, refined honey, macromolecular material, ethanol.Lubricant includes one or more in Pulvis Talci, magnesium stearate, stearic acid.
A kind of He Shi supports the production method of kidney side's granule, capsule, pill, tablet, it is characterized in that: when preparing granule or pill or capsule or tablet, take He Shi and support kidney side's medicinal substances extract and appropriate pharmaceutic adjuvant, through preparation process, prepare granule or pill or capsule or tablet.
3, advantage and effect
First: there are provided a kind of taking convenience, determined curative effect, for treating the oral preparation of Chinese traditional medicinal of chronic renal disease, overcome the defect in existing product field.
Second: provide that a kind of effective ingredient is clear and definite, safety is high, untoward reaction is little, the Chinese medicine preparation of determined curative effect carrys out effective renal function protecting.Preferably provide convenience and help economically to patient, bring huge social benefit to society.He Shi supports the early intervention treatment for chronic kidney disease of the kidney side, abundant and Developing TCM treats chronic kidney disease, widen Chinese Traditional Medicine and treat the bright prospects of great chronic disease, enrich clinician further and treat the means of chronic kidney disease, there is practical value and great social meaning widely.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
Radix Astragali 300g, Radix Rehmanniae 200g, Fructus Corni 150g, Pollen Typhae 130g, Hirudo 30g, Scorpio 30g is weighed by recipe quantity, add the soak by water of 12 times amount, extract 3 times, each 1.5h, decocting liquid filters, and filtrate is concentrated into relative density 1.31～1.35 (80 DEG C), and addition dextrin, sucrose are appropriate, make granule, dry, make 1000g, obtain He Shi and support kidney side's granule；Or loading capsule, obtain He Shi and support kidney side's capsule.
Embodiment 2:
Radix Astragali 300g, Radix Rehmanniae 200g, Fructus Corni 150g, Pollen Typhae 130g, Hirudo 30g, Scorpio 30g is weighed by recipe quantity, above Six-element, the Radix Astragali, Radix Rehmanniae, Pollen Typhae boiling 3 times, each 2h, decocting liquid filters, filtrate is concentrated into relative density 1.31～1.35 (80 DEG C), standby；Fructus Corni, Hirudo, scorpion powder are broken into fine powder, mix with concentrated solution, and addition sucrose, dextrin, low-substituted hydroxypropyl cellulose are appropriate, and add 70% appropriate amount of ethanol, make granule, dry, make 1000g, obtain He Shi and support kidney side's granule；Or loading capsule, obtain He Shi and support kidney side's capsule.
Embodiment 3:
Weigh the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material by recipe quantity, take Fructus Corni, Hirudo, Scorpio, heating and refluxing extraction 2 times in 80% ethanol, each 2 hours, merge ethanol extract；By three taste boilings such as the medicinal residues after ethanol extraction and the Radixs Astragali, extract 3 times, each 1.5h, collecting decoction, filter, filtrate is concentrated into 2000ml, merging ethanol extract and aqueous extract, adding ethanol in proper amount is that alcohol content reaches 70%, cold preservation 24～48 hours, filter, filtrate recycling ethanol is also concentrated into 1600ml, then cold preservation 24～48 hours, filters, add simple syrup 160g, with 10% sodium hydroxide solution regulation pH value to 7.0, add water to 2000ml, shake up, filter, embedding, sterilizing, obtain He Shi and support kidney side's oral liquid.
Embodiment 4:
Weigh the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, boiling by recipe quantity, extract 3 times, each 1h, collecting decoction, filters, and filtrate is concentrated into 2000ml, cold preservation 24～48 hours, filter, then cold preservation 24～48 hours, filter, add simple syrup 150g, with 10% sodium hydroxide solution regulation pH value to 7.0, add water to 2000ml, shake up, filter, embedding, sterilizing, obtain He Shi and support kidney side's oral liquid.
Embodiment 5:
The Radix Astragali of recipe quantity, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material are extracted respectively, concentrates, add pharmaceutic adjuvant and make granule.Take according still further to following weight ratio.
HUANGQI KELI 6g (is equivalent to the crude drug amount containing 30g)
Radix Rehmanniae granule 4g (is equivalent to the crude drug amount containing 20g)
Fructus Corni granule 4.5g (is equivalent to the crude drug amount containing 15g)
Pollen Typhae granule 1.5g (is equivalent to the crude drug amount containing 12.9g)
Hirudo 1.5g (is equivalent to the crude drug amount containing 3g)
Scorpio 1g (is equivalent to the crude drug amount containing 3g).
Embodiment 6:
By recipe quantity, first by Fructus Corni, cattail pollen with 75% ethanol 4 times amount, reflux, extract, 4 times, each 1 hour, be concentrated into extractum, standby；Medicinal residues after alcohol extraction again with the Radix Astragali in prescription, Radix Rehmanniae, Hirudo, the common soak by water of Scorpio, add the water of 8 times amount, decocting extracts 3 times, each 1 hour；Merge decocting liquid, be concentrated into extractum through water-bath, add alcohol-extracted extract, pharmaceutic adjuvant is made He Shi and supported kidney side's pill or granule.
Embodiment 7:
By the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medical material, it is ground into fine powder, sieves, be mixed.Every 100g powder adds refined honey 35-50g and appropriate water, general ball, is dried, makes water-honeyed pill；Or add refined honey 70-120g and make small honey pill or big honeyed pills, obtain He Shi and support kidney side's pill.
Embodiment 8:
Weighing Radix Astragali 150g, Radix Rehmanniae 100g, Fructus Corni 75g, Pollen Typhae 65g, Hirudo 15g, Scorpio 15g, above Six-element by recipe quantity, Fructus Corni, Hirudo, scorpion powder are broken into fine powder, sieve, mixing；Three tastes such as remaining Radix Astragali, add the soak by water of 8 times amount, extract 3 times, each 1.5h, collecting decoction, filter, filtrate is condensed into cream, mixes with above-mentioned powder, cold drying, pulverizes, and adds starch appropriate, it is mixed, makes granule, dry, be pressed into 1000, obtain He Shi and support kidney square piece agent.
Claims (5)
1. a He Shi supports kidney side and production method thereof, it is characterised in that: be by Radix Astragali 10-60 part, Radix Rehmanniae 5-45 part, Fructus Corni 5-35 part,
Pollen Typhae 1-30 part, Hirudo 1-10 part, the crude drug of weight portion of Scorpio 1-10 part are prepared from.
2. a He Shi supports kidney side and production method thereof, it is characterised in that: it is by the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio Six-element medicine
Material, with suitable pharmaceutic adjuvant, through preparation process, prepares oral liquid or granule or pill or capsule or tablet.
3. a He Shi supports the production method of kidney side's granule, capsule, pill, tablet, it is characterised in that: prepare granule or pill or glue
When wafer or tablet, take He Shi and support kidney side's medicinal substances extract and appropriate pharmaceutic adjuvant, through preparation process, prepare granule or pill or capsule or
Tablet.
4. a He Shi supports kidney side's oral liquid and production method thereof, it is characterised in that: it is by the Radix Astragali, Radix Rehmanniae, Fructus Corni, Pollen Typhae, Hirudo, Scorpio
Six-element medicinal substances extract, correctives, preservative and water composition；Pharmaceutic adjuvant includes correctives, preservative；Correctives be simple syrup, stevioside,
One or more in sodium cyclamate, sucrose, LaspartylLphenylalanine methylester, acesulfame first；Preservative be parabens,
One or more in benzoic acids, sorbic acid methyl ester, Oleum Caryophylli.
5. a He Shi supports the production method of kidney side's granule, capsule, pill, tablet, it is characterised in that: prepare granule or pill or capsule
When agent or tablet, pharmaceutic adjuvant used includes diluent, binding agent, lubricant；Diluent includes starch, lactose, sucrose, dextrin, hydroxypropyl
One or more in ylmethyl cellulose, pregelatinized Starch, microcrystalline Cellulose；Binding agent includes in water, refined honey, macromolecular material, ethanol
One or more；Lubricant includes one or more in Pulvis Talci, magnesium stearate, stearic acid.
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Effective date of registration: 20220428 Address after: No.3, Dongcheng section, Songshanhu Avenue, Dongcheng Street, Dongguan City, Guangdong Province, 523000 Patentee after: DONGGUAN TCM Hospital Address before: 523000 Room 903, building 6, phase II, Star River legend Juxing Island, Dongcheng District, Dongguan City, Guangdong Province Patentee before: He Shidong Patentee before: Ning Weimin Patentee before: Deng Lie |