CN106237014A - A kind of Chinese medicine composition treating chronic nephritis - Google Patents
A kind of Chinese medicine composition treating chronic nephritis Download PDFInfo
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- CN106237014A CN106237014A CN201610746357.3A CN201610746357A CN106237014A CN 106237014 A CN106237014 A CN 106237014A CN 201610746357 A CN201610746357 A CN 201610746357A CN 106237014 A CN106237014 A CN 106237014A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of Chinese medicine composition treating chronic nephritis, it is characterised in that this Chinese medicine composition includes following raw medicinal material: Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae.This traditional Chinese medicinal composition raw materials material source is wide, cheap and easy to get, and formula is reasonable, and treatment chronic nephritis is evident in efficacy.
Description
Technical field
The invention belongs to Chinese medicine formulation art, be specifically related to a kind of Chinese medicine composition treating chronic nephritis.
Background technology
Chronic nephritis is the abbreviation of chronic glomerulonephritis, is a kind of common and the chronic kidney disease of refractory.Clinical with
Edema, albuminuria, hematuria, hypertension are characterized, and primary disease is multiple is born in person between twenty and fifty, are to send out after hemolytic streptococcus is infected by body
Raw allergic disease, pathological changes may often be such that bilateral renal diffusivity pathological changes.Mainly being presented with of chronic nephropathy: (1) edema;
(2) hypertension;(3) pain over renal region and renal colic;(4) urinary irritation symptoms (i.e. urgent micturition, dysurea, frequent micturition);(5) paruria (bag
Include hypourocrinia, albuminuria, hematuria, cylinderuria, leukocyturia, pyuria and bacteriuria, the kidney function test positive etc..Chronic nephropathy is such as
Fail timely and effective treatment, the progress that causes that sb.'s illness took a turn for the worse, then to delay with the course of disease, Patients with Chronic Renal Disease will develop into chronic renal merit
Can not entirely, renal failure, ultimately form uremia.
The at present doctor trained in Western medicine therapy such as conventional dialysis and renal transplantation clinically, dialysis can only sustain life, and produce dependency and
Dialysis syndrome, renal transplantation success rate is low, and rejection is also difficult to solve for the moment, and hormonotherapy side effect is obvious, and easily multiple
Sending out, the somewhat expensive of dialysis and renal transplantation often makes numerous patients be difficult to bear in addition.
Chronic nephritis had the longest a period of time before developing into renal failure, this stage active treatment, used Chinese medicine to carry out
Conditioning, the most economical, moreover it is possible to obtain the more preferable curative effect of relative doctor trained in Western medicine, it may be said that Chinese medicine is very to treatment chronic nephritis
Have superiority.
Chinese traditional treatment chronic nephritis uses righting with the eliminating evil and eliminating evil principle being treatment with peace just two big rules.Chronic nephritis
Generation, recurrence, protracted course of disease, relevant with some antibacterial or virus infection.Therefore, efficiently controlling infection is to promote the state of an illness to fully recover
With the key of prevention of recurrence, the Chinese herbal medicine of antipyretic and antidotal type has stronger anti-infectious function.So, tcm clinical practice treatment is chronic
During nephritis, on the basis of tonifying speen and tonifying kidney, often add some heat-clearing and toxic substances removing or activating blood circulation to dissipate blood stasis medicine, to improve clinical efficacy.
Summary of the invention
It is desirable to provide a kind of Chinese medicine composition treating chronic nephritis.
For achieving the above object, a kind of Chinese medicine composition treating chronic nephritis of the present invention, specific embodiments is:
A kind of Chinese medicine composition treating chronic nephritis of the present invention, it is characterised in that this Chinese medicine composition includes the most former
Material medical material: Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, these Chinese medicine composition prescription parts by weight are calculated as:
Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae each 10-20 part, Radix Codonopsis, Poria, Radix Angelicae Sinensis each 5-15 part, Rhizoma Chuanxiong, Radix Cyathulae each 15-30 part.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, these Chinese medicine composition prescription parts by weight are calculated as:
Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 15 parts of Rhizoma Dioscoreae, each 10 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 20 parts of Rhizoma Chuanxiong, Radix Cyathulae.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, this Chinese medicinal composition preparation preparation method include with
Lower step:
1) weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize the most respectively, cross 60-80 mesh sieve, standby;
2) take Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae coarse powder, add medical material total amount 5-10 times amount
Water soaking 1-3 hour, then decoct 1-4 time, each 1-2 hour, filter and retain filtering residue, merging filtrate, filter vacuum subtracts
Pressure is concentrated under the conditions of 60 DEG C and surveys relative density is the concentrated solution of 1.05-1.15, obtains water extracting liquid;
3) toward step 2) in filtering residue in add medical material total amount 5-10 times amount volume fraction be the ethanol of 60-80%, reflux, extract, 2-
3 times, filtering, merging filtrate, it is the concentrated solution of 1.05-1.15 that filter vacuum is evaporated under the conditions of 60 DEG C survey relative density,
Obtain alcohol extraction concentrated solution;
4) combining step 2) and 3) concentrated solution, it is dried, extractum is pulverized, preparation.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, this Chinese medicinal composition preparation can be granule,
Tablet, capsule, patch, pill.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, this Chinese medicinal composition preparation is in treatment chronic nephritis
In application.
A kind of Chinese medicine composition treating chronic nephritis of the present invention, this Chinese medicinal composition preparation primary raw material medicine is being controlled
Treat the application in chronic nephritis.
The each component analysis of the present invention:
Radix Codonopsis: property is put down, sweet in the mouth;Enter spleen channel, lung meridian.Strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid.
Semen Lablab Album: sweet light;Tepor;Flat.Return spleen channel, stomach warp.Spleen invigorating, removing dampness, relieve summer heat.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature;Return spleen, stomach warp.Air making-up and spleen enlivening, dampness diuretic, hidroschesis.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Supplementing QI and nourishing YIN, mends strengthening spleen and lung, tonifying the kidney to consolidate the essence.
Poria: sweet, light is flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, calm the nerves.
Radix Angelicae Sinensis: sweet, pungent, temperature.Return liver, the heart, spleen channel.Promoting blood circulation and stopping pain, tonifying blood and regulating menstruation, loosening bowel to relieve constipation.
Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Cyathulae: property is put down, sweet in the mouth, micro-hardship;Return liver, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.
Prescription analysis of the present invention:
The present invention selects Radix Codonopsis, Rhizoma Dioscoreae invigorating spleen and kidney, supplementing QI for promoting the production of body fluid, selects Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Poria spleen invigorating, removing dampness, calms the nerves,
Selecting Radix Angelicae Sinensis, Rhizoma Chuanxiong blood-activating and qi-promoting, Radix Cyathulae inducing diuresis for treating stranguria syndrome, Chinese medicine preparation of the present invention has invigorating spleen and kidney, the merit of removing dampness blood stasis dispelling
Effect, is for oral administration pure Chinese herbal medicine composition preparation for the treatment of chronic nephritis.By Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis,
Monarch in the crude drug such as Rhizoma Chuanxiong, Radix Cyathulae, minister, help, be allowed between synergism, bring out the best in each other, while vital base and primordial QI consolidating, permissible
Patient's toxin is effectively got rid of, thus reach to let out turbid heat-clearing and toxic substances removing, purging FU-organs rushes down turbid, diuretic, effect of enriching yin and nourishing kidney.
Detailed description of the invention
Example below, only for further illustrating the present invention, limits the scope of the invention the most in any form.
Embodiment 1
Prescription: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 15 parts of Rhizoma Dioscoreae, each 10 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 20 parts of Rhizoma Chuanxiong, Radix Cyathulae.
Embodiment 2
Prescription: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 18 parts of Rhizoma Dioscoreae, each 10 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 25 parts of Rhizoma Chuanxiong, Radix Cyathulae.
Embodiment 3
Prescription: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 20 parts of Rhizoma Dioscoreae, each 15 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 30 parts of Rhizoma Chuanxiong, Radix Cyathulae.
Embodiment 4
Prescription: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 18 parts of Rhizoma Dioscoreae, each 12 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 20 parts of Rhizoma Chuanxiong, Radix Cyathulae.
Embodiment 1-4 formulation preparation method:
1) weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize the most respectively, cross 60-80 mesh sieve, standby;
2) take Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae grass coarse powder, add medical material total amount 8 times amount
Water soaking 2 hours, then decocts 2 times, each 1-2 hour, filters and retain filtering residue, merging filtrate, filter vacuum concentrating under reduced pressure
Surveying relative density under the conditions of 60 DEG C is the concentrated solution of 1.05-1.15, obtains water extracting liquid;
3) toward step 2) in filtering residue in add medical material total amount 6 times amount volume fraction be the ethanol of 60-80%, reflux, extract, 2 times,
Filtering, merging filtrate, it is the concentrated solution of 1.05-1.15 that filter vacuum is evaporated under the conditions of 60 DEG C survey relative density, obtains alcohol
Carry concentrated solution;
4) combining step 2) and 3) concentrated solution, it is dried, extractum is pulverized, preparation (granule, tablet, capsule, patch, ball
Agent).
Clinical data:
Randomly drawing clinical chronic nephritis case 100 example, the age, from 25-65,40 years old mean age, takes the present invention and implements
Example 1 granule, once a bag, three times on the one, 15 days be a course for the treatment of.
Curative effect diagnostic criteria:
Cure: the symptoms such as edema, oliguria, hematuria, hypertension disappear entirely;Effective: the symptoms such as edema, oliguria, hematuria, hypertension
Significantly alleviate;Effective: the symptoms such as edema, oliguria, hematuria, hypertension are improved, and serum urea nitrogen, creatinine clearance rate are stable, urine is often
Rule are at normal range value;Invalid: symptom, sign have no and be obviously improved, and even deteriorate or turn operative treatment.
After above-mentioned patient takes 5-8 the course for the treatment of of granule of the present invention, curing 5, effective 28, effective 41, invalid 26, the present invention is to controlling
Treat chronic nephritis total effective rate 74%.
Claims (7)
1. the Chinese medicine composition treating chronic nephritis, it is characterised in that this Chinese medicine composition includes following raw medicinal material: party
Ginseng, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae.
A kind of Chinese medicine composition treating chronic nephritis, it is characterised in that at this Chinese medicine composition
Side's parts by weight are calculated as: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae each 10-20 part, Radix Codonopsis, Poria, Radix Angelicae Sinensis each 5-15 part, and Rhizoma Chuanxiong, Radix Cyathulae are each
15-30 part.
A kind of Chinese medicine composition treating chronic nephritis, it is characterised in that at this Chinese medicine composition
Side's parts by weight are calculated as: Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, each 15 parts of Rhizoma Dioscoreae, each 10 parts of Radix Codonopsis, Poria, Radix Angelicae Sinensis, each 20 parts of Rhizoma Chuanxiong, Radix Cyathulae.
A kind of Chinese medicine composition treating chronic nephritis, it is characterised in that this Chinese medicine composition system
Agent preparation method comprises the following steps:
1) weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize the most respectively, cross 60-80 mesh sieve, standby;
2) take Radix Codonopsis, Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae coarse powder, add medical material total amount 5-10 times amount
Water soaking 1-3 hour, then decoct 1-4 time, each 1-2 hour, filter and retain filtering residue, merging filtrate, filter vacuum subtracts
Pressure is concentrated under the conditions of 60 DEG C and surveys relative density is the concentrated solution of 1.05-1.15, obtains water extracting liquid;
3) toward step 2) in filtering residue in add medical material total amount 5-10 times amount volume fraction be the ethanol of 60-80%, reflux, extract, 2-
3 times, filtering, merging filtrate, it is the concentrated solution of 1.05-1.15 that filter vacuum is evaporated under the conditions of 60 DEG C survey relative density,
Obtain alcohol extraction concentrated solution;
4) combining step 2) and 3) concentrated solution, it is dried, extractum is pulverized, preparation.
5. according to the Chinese medicine composition treating chronic nephritis a kind of described in any one of claim 1-5, it is characterised in that this Chinese medicine
Composite preparation can be granule, tablet, capsule, patch, pill.
A kind of Chinese medicine composition treating chronic nephritis, it is characterised in that this Chinese medicine composition system
Agent application in treatment chronic nephritis.
A kind of Chinese medicine composition treating chronic nephritis, it is characterised in that this Chinese medicine composition system
The application in treatment chronic nephritis of the agent primary raw material medicine.
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CN201610746357.3A CN106237014A (en) | 2016-08-29 | 2016-08-29 | A kind of Chinese medicine composition treating chronic nephritis |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111686008A (en) * | 2020-07-20 | 2020-09-22 | 温州海鹤药业有限公司 | Mixed-decocting traditional Chinese medicine phosphorus removal process |
-
2016
- 2016-08-29 CN CN201610746357.3A patent/CN106237014A/en active Pending
Non-Patent Citations (1)
Title |
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王昃睿等: "《名老中医王治强临床经验荟萃》", 30 June 2015, 科学技术文献出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111686008A (en) * | 2020-07-20 | 2020-09-22 | 温州海鹤药业有限公司 | Mixed-decocting traditional Chinese medicine phosphorus removal process |
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