CN106137453B - A kind of Real-time Feedback multi-mode oxygen control system - Google Patents
A kind of Real-time Feedback multi-mode oxygen control system Download PDFInfo
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- CN106137453B CN106137453B CN201610752630.3A CN201610752630A CN106137453B CN 106137453 B CN106137453 B CN 106137453B CN 201610752630 A CN201610752630 A CN 201610752630A CN 106137453 B CN106137453 B CN 106137453B
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Abstract
The present invention relates to a kind of Real-time Feedback multi-mode oxygen control system, including compressed oxygen cylinder, compressed nitrogen gas cylinder, compressed air bottle, animal nacelle and single-chip computer control system, the outlet of the compressed oxygen cylinder is pooled to after air inlet pipe by the outlet of oxygen hose, compressed nitrogen gas cylinder by nitrogen tube and compressed air bottle by air hose provides gas into animal capsule body；First gas control device, second gas control device and third gas control device are respectively equipped with the oxygen hose, nitrogen tube and air hose, the single-chip computer control system can make the environment in animal capsule body be changed into intermittent hypoxia pattern, Constant hypoxia pattern, normal oxygen pattern or continue hyperoxia pattern by adjusting gas control equipment.The beneficial effects of the invention are as follows：Using air pressure in blood oxygen saturation, oxygen concentration and nacelle as feedback information, by adjusting gas supply flow and pattern, gas in nacelle is uniformly distributed rapidly and is reached required oxygen supply state, simulate different oxygen environments.
Description
Technical field
The present invention relates to medical experiment field, and in particular to a kind of Real-time Feedback multi-mode oxygen control system.
Background technology
Obstruction sleep apnea-hypopnea syndrome (OSAHS) with repeated in patient sleeps epithelium healing completely and
(or) incomplete obstruction causes apnea or low pass gas to be characterized, its crucial pathologic, physiologic link is chronic intermittent hypoxia
(chronic intermittent hypoxia, CIH).Gradually closed because of its infringement to systems such as cardiovascular and cerebrovasculars by people
Note, and one of hot issue as Recent study.Establish preferable OSAHS animal models and great difficulty be present, thus it is real
Most intermittent hypoxia animal model for applying sleep apnea pattern in the research of border, simulation cycle hypoxia-reoxygenation process,
To study OSAHS Multisystem damage.The mode for realizing chronic intermittent hypoxia (CIH) is mainly interval suction low-oxygen gas mixture body
With interval ventilation blocked method.Wherein the former is CIH models most widely used at present.The principle of above-mentioned model is by various methods
Realize SaO in animal body2Periodically reduce and recover, so as to simulate the chronic intermittent hypoxia processes of OSAHS in patient body.According to
Offering oxygen way is different, and the experimental provision for establishing chronic intermittent hypoxia animal experimental model at present has different type:1. move back and forth
Formula hypoxemia cabin, it is that hypoxemia cabin moves back and forth between animal capsule, animal capsule interval is entered low-oxygen environment, can simulate substantially repeatedly
The pathophysiological features of hypoxia/reoxygenation, but, complex operation high to equipment requirement, and can not exclude to move repeatedly animal to experiment
Caused influence；2. hypobaric hypoxia cabin, different height above sea levels is simulated by changing oxygen cabin elevation rate, produces different pressure
And oxygen concentration, so as to reach the effect of hypoxemia-reoxygenation, the requirement to equipment is higher, it is impossible to accurately reflects the feelings of anoxic under normal pressure
Condition；3. low O2High CO2Case, using singlechip technology and feedback principle, automatically adjust O in oxygen cabin2、CO2Concentration, establish hypoxemia and
CO2Retention model, it is impossible to exclude CO2Interference effect in hypoxemia-reoxygenation Mechanism Study；4. low-oxygen gas mixture body cabin, is also
Using singlechip technology and feedback principle, O in oxygen cabin is automatically adjusted2Concentration, low-oxygen gas mixture body and normal oxygen are provided by interval
Gas, intermittent hypoxia process is simulated, while lime stone CO absorption is placed by rapid aeration or in nacelle2Maintain CO in nacelle2
It is maintained at low-level.
Said apparatus can be automatically controlled by computer program can quickly and easily adjust as needed hypoxemia degree,
The parameter such as frequency and duration, meet different degrees of and various durations CIH requirement, but said apparatus still suffers from one
Determine shortcoming, such as：
(1) one side air inlet, fast intermittent give low-oxygen gas may cause in cabin oxygen concentration skewness cause every it is dynamic
Degree of oxygen deficiency is inconsistent in object, and feeder defect causes pressure change in hypoxia-reoxygenation process nacelle big, it is impossible to which simulation is normal
Press experimental state；
(2) the long-term monitoring in real time to every experimental animal SaO2 is lacked, it is impossible to which clear and definite whether modeling is successful；
(3) due to the limitation of animal nacelle and gas control equipment, same group of experimental group modeling, time can only be carried out every time
Cost is high；
(4) more crucially above-mentioned experimental provision is the finger for being used as judge hypoxemia degree by detecting oxygen concentration in nacelle
Mark, and concentration is supplied oxygen by oxygen concentration feedback regulation in nacelle, but oxygen concentration can not represent the reality in animal body in nacelle
Oxygen closes situation, and body blood oxygen saturation depends primarily on arterial blood sample partial pressure, by multifactor shadows such as alveolar ventilation volume, oxygen supply concentration
Ring, the factor such as uneven, animal individual difference of oxygen concentration can cause degree of oxygenation difference in animal body in nacelle, make real with group
Test result and produce error, therefore oxygen concentration as assessment experimental animal degree of oxygen deficiency and does not meet physiological requirement using in nacelle.
The content of the invention
In summary, for overcome the deficiencies in the prior art, the technical problems to be solved by the invention are to provide a kind of real
When feedback multi-mode oxygen control system.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of Real-time Feedback multi-mode oxygen control system, bag
Include compressed oxygen cylinder, compressed nitrogen gas cylinder, compressed air bottle, animal nacelle and single-chip computer control system, the single-chip microcomputer control system
System includes computer, monolithic machine host, pressure sensor, oxygen concentration sensor, blood oxygen saturation probe and data processing mould
Block, is provided with oxygen concentration sensor and pressure sensor in animal capsule body, each experimental animal in the animal capsule body
Blood oxygen saturation probe is bound with it, and blood oxygen saturation probe, pressure sensor and the oxygen concentration sensor pass through data
Line connects the data processing module of the single-chip computer control system；The data processing module is used to receive, handle and change to adopt
The air pressure in animal capsule body, oxygen concentration and the blood oxygen saturation initial data collected, and will be converted after data be conveyed to list
Piece machine host carries out feedback regulation, while is transported to computer through single-chip microcomputer again and shows that progress is real-time through computer display screen
Monitoring；
The outlet of the compressed oxygen cylinder passes through nitrogen tube and described by the outlet of oxygen hose, the compressed nitrogen gas cylinder
Compressed air bottle is pooled to air inlet pipe by air hose, and the air inlet pipe is separated into five different branch pipes respectively to the animal
Gas is provided in nacelle；
The first gas control device that control oxygen is entered in the animal capsule body is provided with the oxygen hose, in institute
State the nitrogen tube and be provided with the second gas control device that control nitrogen is entered in the animal capsule body, in the air hose
The third gas control device that control air is entered in the animal capsule body is provided with, the single-chip computer control system passes through institute
First gas control device, second gas control device and third gas control device are stated to control respectively from the compressed oxygen
Bottle, the compressed nitrogen gas cylinder and the compressed air bottle are delivered to corresponding gas flow in the animal capsule body, and described
Single-chip computer control system can be by adjusting the first gas control device, the second gas control device and third gas
Control device makes to realize intermittent hypoxia pattern, Constant hypoxia pattern, normal oxygen pattern in animal capsule body or continues hyperoxia pattern
Oxygen supply pattern, different medical experiments is carried out to the animal in the animal capsule body under different oxygen environments so as to realize.
The beneficial effects of the invention are as follows：The control system uses blood oxygen saturation in animal body, oxygen concentration in animal capsule body
And air pressure is as feedback information, by computer to single-chip microcomputer set needed for different degrees of blood oxygen saturation or oxygen concentration and
Duration and the single-chip microcomputer control program inputted in single-chip computer control system, entered so as to adjust each gas in animal capsule body
Gas flow, make to be rapidly reached required oxygen environment in animal capsule body, at the same by multiple spot multiaspect supply make in animal capsule body
Oxygen concentration is uniformly distributed rapidly, and then makes blood oxygen saturation in animal body keep being fitted and maintaining preset range, mould as far as possible
Intend different oxygen environments and carry out medical experiment, while the actual oxygen in animal body can be monitored in real time and close situation.
On the basis of above-mentioned technical proposal, the present invention can also do improvement further below：
Further, the first gas control device includes first gas flowmeter, the first magnetic valve and first timer,
The first gas flowmeter entrance connects the outlet of the compressed oxygen cylinder, and the first gas flowmeter outlet passes through described
First magnetic valve connects the oxygen hose, be provided with first magnetic valve timing controlled its be turned on or off described the
One timer, the single-chip computer control system is by controlling the first magnetic valve described in the first timer time switch；
The second gas control device includes second gas flowmeter, second solenoid valve and second timer, and described
Two gas flowmeter entrances connect the outlet of the compressed nitrogen gas cylinder, and the second gas flowmeter outlet passes through the described second electricity
Magnet valve connects the nitrogen tube, second timing that it is turned on or off provided with timing controlled in the second solenoid valve
Device, the single-chip computer control system is by controlling second solenoid valve described in the second timer time switch；
The third gas control device includes third gas flowmeter and the 3rd magnetic valve, the third gas flowmeter
Outlet connects the air hose by the 3rd magnetic valve.
Using having the beneficial effect that for above-mentioned further technical scheme：Input animal is adjusted by corresponding gas control equipment
The input flow rate of corresponding gas in nacelle, different oxygen supply concentration is provided to animal nacelle so as to realize, is finally simulated different
Oxygen environment carries out medical experiment.
Further, the animal nacelle is cube structure, and five branch roads are respectively from four sides of the animal nacelle
Face and top surface are communicated in animal capsule body.
Using having the beneficial effect that for above-mentioned further technical scheme：Multiaspect supply makes gas rapid uniform in animal capsule body
Distribution.
Further, the bottom surface of the animal nacelle can pull out that animal capsule is external, be provided with the side of the animal nacelle
For the window operated to its inside.
Using having the beneficial effect that for above-mentioned further technical scheme：It is easy to the cleaning and operation inside animal capsule body.
Further, the gas outlet for being used for discharging its internal gas, the gas outlet are provided with the side of the animal nacelle
Exhaust flow-meter and exhaust solenoid valve are connected by pipeline.
Using having the beneficial effect that for above-mentioned further technical scheme：The air pressure in the animal capsule body is set to remain at often
Pressure condition.
Further, the calcium carbonate for absorbing carbon dioxide is placed with the animal capsule body.
Using having the beneficial effect that for above-mentioned further technical scheme：Maintain CO in animal capsule body2In low-level, animal is excluded
High CO in nacelle2Influence to experiment.
Further, the animal nacelle is provided with multiple, and is provided with first gas correspondingly with the animal nacelle
Control device, second gas control device and third gas control device.
Using having the beneficial effect that for above-mentioned further technical scheme：Each animal nacelle carries out one group of zoopery, can be same
The zoopery of the multigroup same experiment parameters of Shi Jinhang, the zoopery of multigroup different experiments parameter can be also carried out simultaneously.
Further, the single-chip computer control system also includes blood oxygen saturation warning device, and institute can be set in the computer
State the alarming value of warning device.
Using having the beneficial effect that for above-mentioned further technical scheme：Avoid because individual difference causes individual animal severe depletion of oxygen
It is dead.
Further, the single-chip computer control system also includes being respectively used to detect and showing first magnetic valve, second
The indicator lamp that magnetic valve and the 3rd magnetic valve are turned on or off.
It is using the above-mentioned further beneficial benefit of technical scheme：By observing the closed mode of corresponding indicator lamp, in real time
Monitor oxygen in animal capsule body, nitrogen and air supply state.
Brief description of the drawings
Fig. 1 is the connection diagram (an animal nacelle, and remove single-chip computer control system) of the present invention；
Fig. 2 is principle of the invention control block diagram (two animal nacelles).
In accompanying drawing, the list of parts representated by each label is as follows：
1st, compressed oxygen cylinder, 2, compressed nitrogen gas cylinder, 3, compressed air bottle, 4, animal nacelle, 5, first gas flowmeter, 6,
First timer, the 7, first magnetic valve, 8, oxygen hose, 9, second gas flowmeter, 10, second timer, the 11, second electromagnetism
Valve, 12, nitrogen tube, 13, third gas flowmeter, the 14, the 3rd magnetic valve, 15, air hose, 16, air inlet pipe, 18, gas outlet,
17th, exhaust flow-meter, 19, exhaust solenoid valve.
Embodiment
The principle and feature of the present invention are described below in conjunction with accompanying drawing, the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the present invention.
As shown in figure 1, a kind of Real-time Feedback multi-mode oxygen control system, including compressed oxygen cylinder 1, compressed nitrogen gas cylinder 2, pressure
Contracting air bottle 3, animal nacelle 4 and single-chip computer control system, the single-chip computer control system include computer, monolithic machine host,
Pressure sensor, oxygen concentration sensor, blood oxygen saturation probe and data processing module, are set aerobic in animal nacelle 4
Concentration sensor and pressure sensor, blood oxygen saturation is bound with each experimental animal in the animal nacelle 4 and is visited
Head, the blood oxygen saturation probe, pressure sensor and oxygen concentration sensor connect the single-chip microcomputer control system by data wire
The data processing module of system；The data processing module is used to receiving, handle and changing the pressure collected, oxygen concentration and blood oxygen
Saturation degree initial data, and will be converted after data be conveyed to monolithic machine host and carry out feedback regulation, while again through single-chip microcomputer
Computer is transported to come out through computer display screen real-time display.
The calcium carbonate for absorbing carbon dioxide is placed with the animal nacelle 4, passes through a part of CO of carbonic acid calcium uptake2
CO in animal nacelle 4 is maintained afterwards2In low-level, high CO in animal nacelle 4 is excluded2Influence to experiment.
The compressed oxygen cylinder 1 outlet by oxygen hose 8, the compressed nitrogen gas cylinder 2 outlet by nitrogen tube 12 with
And the compressed air bottle 3 is pooled to air inlet pipe 16 by air hose 15, the air inlet pipe 16 is separated into five different branch pipes
Respectively gas is provided into the animal nacelle 4.The animal nacelle 4 is cube structure, and five branch roads are respectively from described
Four sides of animal nacelle 4 and top surface are communicated in animal nacelle 4.The bottom surface of the animal nacelle 4 can pull out animal
Outside nacelle 4, the window for being used for being operated to its inside is provided with the side of the animal nacelle 4.In the animal nacelle 4
Side is provided with the gas outlet 18 for being used for discharging its internal gas, and the gas outlet 18 connects exhaust flow-meter 17 and row by pipeline
Pneumoelectric magnet valve 19, the single-chip computer control system is by adjusting and controlling the exhaust flow-meter 17 and exhaust solenoid valve 19 to control
Flow of exhaust amount, and then the air pressure in the animal nacelle 4 is remained at atmospheric pressure state.As shown in Fig. 2 according to reality
Need, the animal nacelle 4 is provided with one or more, and is provided with first gas correspondingly with the animal nacelle 4
Control device, second gas control device and third gas control device.Set by SCM program and carry out different oxygen supplys
The zoopery of environment, one or more groups of zooperies can be carried out simultaneously.
The first gas control device that control oxygen is entered in the animal nacelle 4 is provided with the oxygen hose 8,
The nitrogen tube 12 is provided with the second gas control device that control nitrogen is entered in the animal nacelle 4, in the air
Pipe 15 is provided with the third gas control device that control air is entered in the animal nacelle 4.First gas control device,
Two gas control equipments and third gas control device are specific as follows：
The first gas control device includes first gas flowmeter 5, the magnetic valve 7 of first timer 6 and first, described
The entrance of first gas flowmeter 5 connects the outlet of the compressed oxygen cylinder 1, and the outlet of first gas flowmeter 5 passes through described
First magnetic valve 7 connects the oxygen hose 8, the institute that it is turned on or off provided with timing controlled on first magnetic valve 7
First timer 6 is stated, the single-chip computer control system is by controlling the first magnetic valve described in the time switch of first timer 6
7；
The second gas control device includes second gas flowmeter 9, second timer 10 and second solenoid valve 11, institute
The outlet that the entrance of second gas flowmeter 9 connects the compressed nitrogen gas cylinder 2 is stated, the outlet of second gas flowmeter 9 passes through institute
State second solenoid valve 11 and connect the nitrogen tube 12, being provided with timing controlled in the second solenoid valve 11, it is turned on or off
The second timer 10, the single-chip computer control system is by controlling second described in the time switch of second timer 10
Magnetic valve 11；
The third gas control device includes the meter of third gas flow 13 and the 3rd magnetic valve 14, the third gas stream
The outlet of gauge 13 connects the air hose 15 by the 3rd magnetic valve 14.
The single-chip computer control system passes through the first gas control device, second gas control device and third gas
Control device is delivered to institute to control respectively from the compressed oxygen cylinder 1, the compressed nitrogen gas cylinder 2 and the compressed air bottle 3
Corresponding gas flow in animal nacelle 4 is stated, and the single-chip computer control system is by adjusting the first gas control dress
Put, the second gas control device, the third gas control device can make the environment in animal capsule body 4 be changed into intermittently low
Oxygen, Constant hypoxia, normal oxygen or a variety of oxygen environments for continuing hyperoxia, so as to realize under different oxygen environments to the animal
Animal in nacelle 4 carries out medical experiment.The single-chip computer control system also includes being respectively used to detect and showing described first
The indicator lamp that magnetic valve 7, the magnetic valve 14 of second solenoid valve 11 and the 3rd are turned on or off, by observing corresponding indicator lamp
Closed mode, oxygen in animal capsule body, nitrogen and air supply state are monitored in real time, when corresponding indicator lamp lights, is represented
Corresponding magnetic valve is opening, i.e., is supplied in corresponding gas forward direction animal capsule body.
The control system is programmed by the PLC program of single-chip computer control system, can be to various gas flows and time
It is controlled, can perform intermittent hypoxia pattern, normal oxygen pattern, Constant hypoxia pattern, the multiple-working mode of hyperoxia pattern, below
Illustrate respectively：
(1) intermittent hypoxia pattern implementation example：
Experiment is default：Single-chip computer control system presets the blood oxygen saturation desired value of animal in the test group of animals nacelle 4
Scope is 82%-85%, and the working time of second timer 10 for controlling nitrogen to supply is 30s, intermittent time 40s, i.e. hypoxemia
Interval is 30s, and normal oxygen interval is 40s.
Embodiment：
1. the first timer 6 supplied by the control of single-chip computer control system closing control oxygen, and set blood oxygen saturation
Target range is 82%-85%, and the working time of second timer 10 for controlling nitrogen to supply is 30s, and the intermittent time is
40s------ parameter settings；
2. after the intermittent hypoxia model program for starting single-chip computer control system, the He of second timer 10 of control nitrogen supply
Second solenoid valve 11 is opened, the supplying nitrogen into animal nacelle 4, while exhaust solenoid valve 19 is also opened rapidly, single-chip microcomputer control
The data that the data and oxygen concentration sensor that system detects according to the blood oxygen saturation inspection probe with animal detect are adjusted
The second gas flowmeter 9 of nitrogen supply is controlled, so as to the nitrogen flow in control input animal nacelle 4, according to animal nacelle 4
Data that pressure sensor detects regulation extraction flow, pressure is constant to maintain in animal nacelle 4, makes in animal nacelle 4
Oxygen concentration declines rapidly, the blood oxygen saturation of each animal in animal nacelle 4 is dropped to preset range with most fast speed, and to the greatest extent
Fitting --- ----this is nitrogen conveying process may be kept, that is, realizes hypoxia；
3. when animal blood oxygen saturation drops to preset level in animal nacelle 4, and nitrogen supply is controlled after tending to fitting
Second solenoid valve 11 and exhaust solenoid valve 19 close, maintain hypoxia 30s------ hypoxemia in animal nacelle 4 to maintain rank
Section, i.e. hypoxemia interval；
4. controlling the second timer 10 of nitrogen supply to close automatically after reaching 30s, while control the second of nitrogen supply
Also automatic the first magnetic valve 7 and the automatic opening of exhaust solenoid valve 19 closed, now control oxygen supply of magnetic valve 11, start to
Conveying oxygen, makes oxygen concentration in animal nacelle 4 recover to normal oxygen condition, makes animal blood oxygen with most fast speed in animal nacelle 4
Saturation degree recovers to normal level --- --- reoxygenation process；
5. the first magnetic valve 7 of oxygen supply is controlled to close automatically after oxygen concentration reaches normal oxygen condition in animal nacelle 4
Close, the 3rd magnetic valve 14 of control air supply opens, and starts to convey air into animal nacelle 4, maintains in animal nacelle 4 often
Oxygen condition, --- --- often oxygen maintenance rank is reopened after the intermittent time of second timer 10 of control nitrogen supply reaches 40s
Section, i.e., normal oxygen interval；
6. the second solenoid valve 11 and exhaust solenoid valve 19 that now control nitrogen supply open again, again to animal nacelle
Supplying nitrogen in 4, so repeatedly, supplying nitrogen-oxygen-air is repeated, to reach the circulation --- -- the of the oxygen of hypoxemia-reoxygenation-often
Secondary cycle.
In addition, if there is multiple animal nacelles 4, each working method of animal nacelle 4 is by single-chip computer control system
Independent control, different experiment parameters is can perform, such as default blood oxygen saturation desired value of other animal nacelle 4 requirement is 65%-
68%%, the working time for controlling the second timer 10 of nitrogen supply is 40s, intermittent time 50s, and passes through single-chip microcomputer journey
Sequence is designed, and different experiment parameter instructions can be transmitted, and different experiment parameters is performed simultaneously to different animal nacelles 4, i.e., same
The different zoopery of the multigroup experiment parameters of Shi Jinhang.
(2) normal oxygen pattern
Most simple, other switches are turned off in addition to air controls magnetic valve and exhaust solenoid valve, are continued toward defeated in nacelle
Air is sent, experimental comparison group pattern can be used as.
(3) Constant hypoxia pattern
Experiment is default：Animal blood oxygen saturation target range is 70%-73% in default animal nacelle 4, and hypoxemia is lasting
Time is 3h.
Embodiment：
1. the first timer 6 supplied by single-chip computer control system closing control oxygen, set default blood oxygen saturation
Target range is 70%-73%, and it is 3h----- parameters to set the working time of second timer 10 for controlling nitrogen to supply
Set；
2. after the Constant hypoxia model program for starting single-chip computer control system, the He of second solenoid valve 11 of control nitrogen supply
Second timer 10 is simultaneously open, starts the supplying nitrogen into animal nacelle 4, and oxygen concentration declines rapidly in animal nacelle 4, so that
Animal blood oxygen saturation is rapidly reached preset range, and tends to be fitted as far as possible, while exhaust solenoid valve 19 also opens, to maintain
Pressure stability and maintain atmospheric pressure state in animal nacelle 4 --- --- realizes hypoxia；
3. now controlling the first magnetic valve 7 of oxygen supply to open, while oxygen and nitrogen are conveyed into animal nacelle 4,
Single-chip computer control system adjusts the transport Stream of oxygen and nitrogen according to the blood oxygen saturation of oxygen concentration and animal in animal nacelle 4
Amount, makes the blood oxygen saturation of animal in animal nacelle 4 maintain preset level all the time, until the second timing of control nitrogen supply
System closes --- --- hypoxemia maintenance stage automatically after the working time of device 10 reaches 3h.
(4) hyperoxia pattern is continued
Experiment is default：Oxygen concentration is 80% in nacelle, and hyperoxia is held time as 3h
Embodiment：
1. controlling the second timer 10 of nitrogen supply by the stop of single-chip computer control system, and set default oxygen
Concentration is 80%, sets the working time for the first timer 6 for controlling oxygen to supply as 3h----- parameter settings；
2. start single-chip computer control system lasting hyperoxia model program after, control oxygen supply the first magnetic valve 7 and
Exhaust solenoid valve 19 opens, and starts to convey oxygen into animal nacelle 4, oxygen concentration in animal nacelle 4 is rapidly reached default water
It is flat, while exhaust solenoid valve 19 opens, with maintain in animal nacelle 4 pressure stability and maintain atmospheric pressure state --- -- realize it is high
Oxygen process；
3. now control the second solenoid valve 11 of nitrogen supply to open, while supplying nitrogen and oxygen into animal nacelle 4,
Single-chip microcomputer control program adjusts the feed flow of oxygen and nitrogen according to oxygen concentration in animal nacelle 4, makes oxygen in animal nacelle 4 dense
Degree maintains preset level all the time, and system is automatic after the working time of the first timer 6 of control oxygen supply reaches 3h
Close --- -- hyperoxia maintenance stage.
In summary, the system has the following advantages that：
1st, fast intermittent, which gives low-oxygen gas, may cause oxygen concentration skewness in cabin to cause anoxic in every animal body
Degree is inconsistent, by the improvement to steam line and animal nacelle, realizes that multiaspect multiple spot supplies, gas in nacelle is divided rapidly
Cloth is uniform, while uses blood oxygen saturation and oxygen concentration single-chip computer control system to be fed back to, according to default blood as feedback information
Oxygen saturation or oxygen concentration levels carry out gas supply flow regulation, make in same animal capsule body with the blood oxygen saturation of group experimental animal
Tend to be fitted, and be maintained at preset range, reduce with group experimental error；
2nd, fast intermittent oxygen supply causes air pressure in nacelle unstable, passes through pressure sensor feedback and the tune of exhaust solenoid valve
Section, makes pressure in nacelle remain at atmospheric pressure state；
3rd, lack to every experimental animal SaO2It is long-term in real time monitoring, it is impossible to it is clear and definite whether modeling success, the system with
For blood oxygen saturation as real-time feedback information, the actual oxygen showed in animal body closes situation, is carried out than oxygen concentration in detection nacelle
Whether it is more accurate that degree of oxygen deficiency is assessed, and clear and definite modeling can succeed immediately；
4th, due to the limitation of animal nacelle and gas control equipment, same group of experimental group modeling, time can only be carried out every time
Cost is high, and the system is different by setting by improving experiment nacelle, gas control equipment, PLC program programming etc. are many-sided
The blood oxygen saturation or oxygen concentration of degree and duration, the air supply requirement of various modes can be achieved, different animals nacelle can be same
The zoopery of mono- group of identical experiment parameter of Shi Jinhang, multigroup zoopery of different experiments parameter can be also carried out simultaneously, shorten
The modeling time, save time cost；
5th, blood oxygen saturation warning device can be set in the PLC control program of single-chip computer control system, can set different range
Alarming value, avoid because individual difference causes individual animal severe depletion of oxygen dead.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (9)
1. a kind of Real-time Feedback multi-mode oxygen control system, it is characterised in that including compressed oxygen cylinder (1), compressed nitrogen gas cylinder
(2), compressed air bottle (3), animal nacelle (4) and single-chip computer control system, the single-chip computer control system include computer, list
Piece machine host, pressure sensor, oxygen concentration sensor, blood oxygen saturation probe and data processing module, in animal nacelle (4)
Inside it is provided with oxygen concentration sensor and pressure sensor, is bound with each experimental animal in the animal nacelle (4)
Blood oxygen saturation is popped one's head in, described in blood oxygen saturation probe, pressure sensor and oxygen concentration sensor are connected by data wire
The data processing module of single-chip computer control system；The data processing module is used to receiving, handle and changing the animal collected
Air pressure, oxygen concentration and the blood oxygen saturation initial data of nacelle (4), and will be converted after data be conveyed to monolithic machine host and enter
Row feedback regulation, while be transported to computer through monolithic machine host again and come out through computer display screen real-time display；
The outlet of the compressed oxygen cylinder (1) passes through nitrogen tube by the outlet of oxygen hose (8), the compressed nitrogen gas cylinder (2)
(12) and the compressed air bottle (3) is pooled to air inlet pipe (16) by air hose (15), and the air inlet pipe (16) is separated into
Five different branch pipes provide gas into the animal nacelle (4) respectively；
The first gas control device that control oxygen is entered in the animal nacelle (4) is provided with the oxygen hose (8),
The nitrogen tube (12) is provided with the second gas control device that control nitrogen is entered in the animal nacelle (4), described
Air hose (15) is provided with the third gas control device that control air is entered in the animal nacelle (4), the single-chip microcomputer
Control system is controlled respectively by the first gas control device, second gas control device and third gas control device
The animal nacelle (4) is delivered to from the compressed oxygen cylinder (1), the compressed nitrogen gas cylinder (2) and the compressed air bottle (3)
Interior corresponding gas flow, and the single-chip computer control system can be by adjusting the first gas control device, described
Second gas control device and third gas control device make intermittent hypoxia, Constant hypoxia, normal oxygen mould are presented in animal nacelle (4)
Formula or a variety of oxygen environments for continuing hyperoxia, so as to realize under different oxygen environments to dynamic in the animal nacelle (4)
Thing carries out different medical experiments.
2. Real-time Feedback multi-mode oxygen control system according to claim 1, it is characterised in that the first gas control
Device includes first gas flowmeter (5), first timer (6) and the first magnetic valve (7), the first gas flowmeter (5)
Entrance connects the outlet of the compressed oxygen cylinder (1), and first gas flowmeter (5) outlet passes through first magnetic valve
(7) connect the oxygen hose (8), be provided with first magnetic valve (7) timing controlled its be turned on or off described the
One timer (6), the single-chip computer control system is by controlling the first magnetic valve (7) described in the timer (6) time switch；
The second gas control device includes second gas flowmeter (9), second timer (10) and second solenoid valve (11),
Second gas flowmeter (9) entrance connects the outlet of the compressed nitrogen gas cylinder (2), and the second gas flowmeter (9) goes out
Mouth connects the nitrogen tube (12) by the second solenoid valve (11), and timing controlled is provided with the second solenoid valve (11)
Its second timer (10) being turned on or off, the single-chip computer control system is by controlling second timer (10) fixed
Second solenoid valve described in Shi Kaiguan (11)；
The third gas control device includes third gas flowmeter (13) and the 3rd magnetic valve (14), the third gas stream
Gauge (13) outlet connects the air hose (15) by the 3rd magnetic valve (14).
3. Real-time Feedback multi-mode oxygen control system according to claim 1, it is characterised in that the animal nacelle (4)
For cube structure, five branch roads are communicated to animal nacelle from four sides of the animal nacelle (4) and top surface respectively
(4) in.
4. Real-time Feedback multi-mode oxygen control system according to claim 3, it is characterised in that the animal nacelle (4)
Bottom surface can pull out animal nacelle (4) outside, be provided with the side of the animal nacelle (4) and be used to operate its inside
Window.
5. Real-time Feedback multi-mode oxygen control system according to claim 1, it is characterised in that in the animal nacelle
(4) side is provided with the gas outlet (18) for being used for discharging its internal gas, and the gas outlet (18) connects exhaust stream by pipeline
Gauge (17) and exhaust solenoid valve (19), the single-chip computer control system by adjust and control the exhaust flow-meter (17) and
The flow of exhaust solenoid valve (19) control discharge gas, and then the air pressure in the animal nacelle (4) is remained at normal pressure
State.
6. Real-time Feedback multi-mode oxygen control system according to claim 1, it is characterised in that the animal nacelle (4)
Inside it is placed with the calcium carbonate for absorbing carbon dioxide.
7. the Real-time Feedback multi-mode oxygen control system according to any one of claim 1 to 6, it is characterised in that described dynamic
Thing nacelle (4) is provided with multiple and one-to-one provided with first gas control device, the second gas with the animal nacelle (4)
Member control apparatus and third gas control device.
8. the Real-time Feedback multi-mode oxygen control system according to any one of claim 1 to 6, it is characterised in that the list
Piece machine control system also includes the warning device of detection blood oxygen saturation, and the alarm of the warning device can be set in the computer
Value.
9. Real-time Feedback multi-mode oxygen control system according to claim 2, it is characterised in that the single-chip microcomputer control system
System also includes being respectively used to detect and showing first magnetic valve (7), second solenoid valve (11) and the 3rd magnetic valve (14)
The indicator lamp being turned on or off.
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| CN107126212A (en) * | 2017-06-16 | 2017-09-05 | 中国科学院亚热带农业生态研究所 | Intelligent animals respiratory metabolism determining system |
| CN108458251A (en) * | 2018-06-08 | 2018-08-28 | 周先林 | Feeding mechanism containing oxygen gas mixture and intermittence low-oxygen Supply Method |
| CN109223391A (en) * | 2018-10-04 | 2019-01-18 | 同惠生物科技（东莞）有限公司 | Information-based animal oxygen cabin and its approaches to IM |
| CN109172213B (en) * | 2018-10-04 | 2023-08-22 | 同惠生物科技（东莞）有限公司 | Intelligent animal oxygen cabin and monitoring method thereof |
| CN109444218B (en) * | 2018-12-17 | 2024-02-20 | 西南科技大学 | Improved environment state simulation device in oxidation kinetics reaction and use method |
| CN109350298B (en) * | 2018-12-20 | 2020-12-22 | 天津市胸科医院 | Ventilation regulating and controlling equipment for realizing intermittent airway obstruction |
| CN110093256A (en) * | 2019-05-23 | 2019-08-06 | 华东理工大学 | A kind of automatic dissolved oxygen cyclic fluctuation device |
| CN110141396A (en) * | 2019-05-24 | 2019-08-20 | 四川大学 | A kind of hypoxia device for clinical zoopery |
| CN110721044A (en) * | 2019-10-17 | 2020-01-24 | 上海塔望智能科技有限公司 | Hyperbaric oxygen chamber for animal experiments |
| CN111920548A (en) * | 2020-08-18 | 2020-11-13 | 南通大学 | Argon-oxygen gas animal experiment hyperbaric chamber and animal experiment method thereof |
| CN113180967B (en) * | 2021-04-30 | 2022-03-25 | 兵器工业卫生研究所 | Normal-pressure low-oxygen pre-study clothes training method and system |
| CN113812347A (en) * | 2021-09-06 | 2021-12-21 | 中国人民解放军海军特色医学中心 | Suit cabin adds decompression system |
| CN117378514B (en) * | 2023-11-29 | 2024-04-02 | 中国人民解放军海军特色医学中心 | Animal experiment system under high-pressure environment |
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