CN105662639A - Fully-automatic oxygen control animal tank - Google Patents

Fully-automatic oxygen control animal tank Download PDF

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Publication number
CN105662639A
CN105662639A CN201610057980.8A CN201610057980A CN105662639A CN 105662639 A CN105662639 A CN 105662639A CN 201610057980 A CN201610057980 A CN 201610057980A CN 105662639 A CN105662639 A CN 105662639A
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China
Prior art keywords
oxygen
animal capsule
animal
electromagnetic valve
conduit
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Pending
Application number
CN201610057980.8A
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Chinese (zh)
Inventor
刘维英
余勤
岳红梅
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First Hospital of Lanzhou University
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First Hospital of Lanzhou University
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Priority to CN201610057980.8A priority Critical patent/CN105662639A/en
Publication of CN105662639A publication Critical patent/CN105662639A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00Housing animals; Equipment therefor
    • A01K1/02Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03Housing for domestic or laboratory animals
    • A01K1/031Cages for laboratory animals; Cages for measuring metabolism of animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00Housing animals; Equipment therefor
    • A01K1/02Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/035Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61GTRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G10/00Treatment rooms or enclosures for medical purposes
    • A61G10/02Treatment rooms or enclosures for medical purposes with artificial climate; with means to maintain a desired pressure, e.g. for germ-free rooms
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D27/00Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00
    • G05D27/02Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00 characterised by the use of electric means

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Wood Science & Technology (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Abstract

The invention relates to a fully-automatic oxygen control animal tank, belongs to the technical field of medical laboratory equipment and aims to solve the problems of automatic control of low-concentration oxygen in the animal tank and distribution uniformity of mixed gas in the animal tank. The whole experiment equipment comprises a nitrogen gas cylinder, an air pump, the animal tank, a buffer tank, a central processing unit, flow meters, a distributor, a plurality of guide pipes, a plurality of cables and the like; the effect of indirectly controlling the oxygen concentration is achieved through regulating the concentration of nitrogen in the animal tank; the oxygen concentration and the time required for maintaining a low-oxygen environment are automatically controlled by the central processing unit; the equipment is high in degree of automation and is not needed to be attended by a specially-assigned person; by the use of the flow meters, the distributor and the buffer tank, the damage caused by fine jet gas to small animals is reduced, and even eliminated; the fully-automatic oxygen control animal tank has the advantage of being uniform and gentle in gas supply, and the phenomenon of concentration distribution non-uniformity of the oxygen in the animal tank is eliminated from the source.

Description

A kind of full-automatic control oxygen animal capsule
Technical field
The invention belongs to medical experiment equipment technical field, relate to a kind of laboratory animal chamber device, particularly relate to a kind of full-automatic control oxygen animal capsule.
Background technology
The respiratory disorder caused when obstruction sleep apnea-hypopnea syndrome (OSAHS) is a kind of sleep, clinical manifestation has nighttime sleep snoring, companion's asphyxia and daytime drowsiness. Owing to asphyxia can cause hypoxia at night and the hypercapnia of recurrent exerbation, may result in the complication such as hypertension, coronary heart disease, diabetes and cerebrovascular disease, even occur that night dies suddenly. At present, there is no desirable OSAHS animal model, and how to be placed in intermittent hypoxia environment with toy, simulate the apneic pathological process of OSAHS patient sleeps, study the pathogenesis of OSAHS with this.
Existing animal intermittent hypoxia device adopt be, based on the automanual system controlling the time, such as apply for a patent 201110205532.5, therefore there is many technical problems: the control of oxygen concentration is ineffective, often result in oxygen concentration in cabin, with setting value, bigger deviation occurs; Owing to device being provided with oxygen cylinder, thus consume oxygen, thus adding the cost of experiment; Animal capsule is Open architecture, oxygen, nitrogen waste serious; In addition oxygen, nitrogen are to be passed directly in animal capsule with conduit, the therefore oxygen skewness in animal capsule. Subregion enrichment nitrogen, causes the oxygen concentration in this region greatly to deviate setting value, not only severely impacts accuracy and the reliability of experimental result, and the severe hypoxia that toy is stayed in this region directly can be caused even to suffocate; , there is thin stock torrent gas and face the phenomenon of toy directly, be unfavorable for the cultivation of toy in the additionally non-blood pressure lowering of gas of input in device.
Summary of the invention
For solving Problems existing in above-mentioned technology, it is an object of the invention to provide a kind of full-automatic control oxygen animal capsule, by the adjustment of nitrogen gas concn, reach indirectly to control the effect of oxygen concentration; And by the depressurized system that effusion meter, surge tank, distributor form, reduce the pressure of input gas step by step, so that the air-flow being input to animal capsule is uniform, mild.
Nitrogen conduit is connected with animal capsule after effusion meter, surge tank. Owing to the main component of air is oxygen and nitrogen, therefore the oxygen concentration in animal capsule of the present invention is controlled indirectly by nitrogen.
Described air pump is connected with animal capsule after effusion meter, surge tank by front end air conduit.
Described central processing unit is the control system of whole device, is responsible for the open and close of air pump and each electromagnetic valve, is responsible for the data process of pressure and oxygen concentration in animal capsule. The intrinsic pressure of animal capsule is detected by pressure transducer, and oxygen concentration is detected by oxygen probe, and the data of they detections send central processing unit to, regulate and control oxygen concentration in cabin in time according to the setting value that different experiments requires. The time data of intrinsic pressure data, oxygen concentration data and setting is the basis that central processing unit judges that each functional part opens and closes. Central processing unit can be made up of electronic chip group and some electronic components, it is also possible to takes on electronic computer.
Described animal capsule is a hermetic container, and top is provided with upper cover, and upper cover can be opened, and built-in feedstuff dish can place feedstuff, external water supply bottle in advance, is available for toy by conduit introducing animal capsule and drinks.
One end of rear end appendix connects with surge tank, and the other end connects with distributor.
Described distributor is a joint blind pipe, two ends be provided with end socket, top has pipe joint of many steam vents and constitutes. Distributor top sets steam vent, and bottom does not set steam vent, and the purpose of do so is, it is to avoid air-flow faces toy directly, if the purpose of numerous steam vent is to make aerofluxus uniform as far as possible.
Pressure transducer, oxygen probe stretch in animal capsule, are fixed on and cover.
Under any state, when animal capsule intrinsic pressure is higher than setting value, the electromagnetic valve on steam vent is opened, and steam vent outwards discharges gas. Intrinsic pressure once reach setting value, electromagnetic valve resets. Intrinsic pressure setting value can be equal to atmospheric value, it is also possible to lower than atmospheric value.
Electromagnetic valve one end on steam vent is arranged in the adapter of upper cover, and the other end of free state constitutes steam vent. It is the passage of gas discharging.
Respectively equipped with effusion meter on front end air conduit, front end nitrogen conduit, effusion meter is provided with adjustment handle, float, regulates handle and controls the uninterrupted of gas, and float plays cushioning effect, can reduce the impulsive force of gas, makes the air-flow of output steadily releive.
Rear end nitrogen conduit, back air conduit are connected with front end appendix by threeway.
Described surge tank is a spherical hollow container, and flatly, upper opening connects upper and lower Ge Kai with rear end appendix, and lower openings connects with front end appendix. The effect of surge tank is the sharply change by appendix caliber, reduces the flow of unit are fluid, and then reaches to reduce the effect of gas pressure. So that the gas delivering into animal capsule is releived, reduce and even eliminate the injury to toy of the thin stock torrent gas.
Beneficial effect: the present invention is a kind of full-automatic control oxygen animal capsule, by regulating the concentration of nitrogen, reaches indirectly to control the effect of oxygen concentration in air; The size of oxygen concentration and the time of maintenance low-oxygen environment, automatically controlling by central processing unit, automaticity is high, waits for without special messenger, alleviates the labor intensity of experimenter; The use of effusion meter, distributor and surge tank, reduces and even eliminates the injury to toy of the thin stock torrent gas, has the advantage that supply is uniform, mild, eliminates animal capsule oxygen concentration phenomenon pockety from source; Additionally equipment simple in construction, be easily worked manufacture, less costly, it is easy to popularization and application.
Accompanying drawing explanation
Fig. 1 present invention automatically controls oxygen animal capsule and auxiliary equipment structural representation
Fig. 2 central processing system structural representation of the present invention
Fig. 3 air pump configuration schematic diagram of the present invention
Fig. 4 animal capsule structural representation of the present invention
Fig. 5 animal capsule internal structure schematic diagram of the present invention
Fig. 6 structure of distributor schematic diagram of the present invention
Accompanying drawing number
Detailed description of the invention
Below in conjunction with accompanying drawing 1 ~ Fig. 6, the invention will be further described:
A kind of full-automatic control oxygen animal capsule is made up of nitrogen cylinder 1, air pump 5, animal capsule 4, surge tank 2, central processing unit 3, effusion meter 17, distributor 45 and several conduit, cable etc.Wherein effusion meter 17, surge tank 2, distributor 45 form the depressurized system of the present invention, by the blood pressure lowering of depressurized system, make the gas of input be reduced to atmospheric value step by step. Central processing unit 3, electromagnetic valve 15, electromagnetic valve 16, electromagnetic valve 42, oxygen probe 11, pressure transducer 10 constitute the central processing system of the present invention.
Containing nitrogen in described nitrogen cylinder 1, nitrogen cylinder 1 is connected with animal capsule 4 after effusion meter, surge tank 2 by front end nitrogen conduit 12. Owing to the main component of air is oxygen and nitrogen, therefore the oxygen concentration in animal capsule 4 of the present invention is controlled indirectly by nitrogen.
Described air pump 5 is connected with animal capsule 4 after effusion meter 17, surge tank 2 by front end air conduit 6.
Described central processing unit 3 is the control system of whole device, is responsible for the open and close of air pump 5, electromagnetic valve 15, electromagnetic valve 16, electromagnetic valve 42, is responsible for the data process of pressure and oxygen concentration in animal capsule 4. The intrinsic pressure of animal capsule 4 is detected by pressure transducer 10, and oxygen concentration is detected by oxygen probe 11, and the data of they detections send central processing unit 3 to. The time data of intrinsic pressure data, oxygen concentration data and setting is the basis that central processing unit 3 judges that each functional part opens and closes. Central processing unit 3 can be made up of electronic chip and some electronic components, it is also possible to takes on electronic computer.
Described animal capsule 4 is a hermetic container, and top is provided with upper cover 61, and upper cover 61 can be opened, and built-in feedstuff dish 46 can place feedstuff, external water supply bottle 41 in advance, is available for toy by conduit introducing animal capsule 4 and drinks.
One end of rear end appendix 44 connects with surge tank 2, and the other end connects with distributor 45.
Described distributor 45 is a joint blind pipe, two ends be provided with end socket 52, top is opened pipe joint of many steam vents 53 and constituted. Distributor 45 top sets steam vent, and bottom does not set steam vent, and the purpose of do so is, it is to avoid air-flow faces toy directly, if the purpose of numerous steam vent is to make aerofluxus uniform as far as possible.
Pressure transducer 10, oxygen probe 11 stretch in animal capsule 4, are fixed on upper cover 61.
Under any state, when animal capsule 4 intrinsic pressure is higher than setting value, electromagnetic valve 42 is opened, and steam vent 43 outwards discharges gas. Intrinsic pressure once reach setting value, electromagnetic valve 42 resets. Intrinsic pressure setting value can be equal to atmospheric value, it is also possible to lower than atmospheric value.
One end of electromagnetic valve 42 is arranged in the adapter of upper cover 61, and the other end of free state constitutes steam vent 43. It is gases at high pressure and the passage of hypoxic air discharge.
Respectively equipped with effusion meter 17 on front end air conduit 6, front end nitrogen conduit 12, effusion meter 17 is provided with adjustment handle 19, float 18, regulates handle 19 and controls the uninterrupted of gas, 18 cushioning effects of float, the impulsive force of gas can be reduced, make the air-flow of output steadily releive.
Rear end nitrogen conduit 13, back air conduit 14 are connected with front end delivery conduit 51 by threeway.
Described surge tank 2 is a spherical hollow container, and flatly, upper opening connects upper and lower Ge Kai with rear end appendix 44, and lower openings connects with front end appendix 51. The effect of surge tank 2 is the sharply change by appendix caliber, reduces the flow of unit are fluid, and then reaches to reduce the effect of gas pressure. So that the gas delivering into animal capsule 4 is releived, reduce and even eliminate the injury to toy of the thin stock torrent gas.
The operation principle of the present invention and job step:
The obstruction sleep apnea-hypopnea syndrome of people its essence is anoxia, simulates anaerobic condition with toy, it is therefore an objective to by changing the concentration of oxygen and holding time, observes the damage that brain is caused by anaerobic condition.According to the difference of anoxia, reoxygenation link in respiratory, simulation experiment cycle can be divided into the following four stage.
The entrance stage of first step anoxia: when reaching the moment that anaerobic condition sets, central processing unit 3 sends instruction, electromagnetic valve 42 cuts out, steam vent 43 on animal capsule 4 is closed, so that animal capsule 4 is in air-tight state, electromagnetic valve 16 is opened, and animal capsule 4 supplying nitrogen given by nitrogen cylinder 1. Oxygen concentration is by oxygen probe 11 timely monitor, and when oxygen concentration reaches the anaerobic condition value set, central processing unit 3 sends instruction, and electromagnetic valve 16 cuts out, and nitrogen conveying stops. This stage electromagnetic valve 15 is closed all the time.
The second step anoxia maintenance stage: this stage is set the retention time by central processing unit 3, this stage, each electromagnetic valve was in closed mode.
The Restoration stage of third step oxygen concentration: when the anoxia moment set reaches, central processing unit 3 sends instruction, electromagnetic valve 42 is opened, gas in animal capsule 4 is outwards discharged by steam vent 43, central processing unit 3 sends instruction unlatching air pump 5, opens electromagnetic valve 15 simultaneously, is carried by fresh air in animal capsule 4. This stage electromagnetic valve 16 is closed all the time.
4th step oxygen concentration normal phase: this initial stage in stage, electromagnetic valve 15, electromagnetic valve 42, air pump 5 are in opening, and when oxygen concentration is constant in the value set, air pump 5 stops, electromagnetic valve 15 cuts out, and namely oxygen concentration value once open air pump 5 lower than setting value. Holding time of this stage is set by central processing unit 3. This stage electromagnetic valve 16 is closed all the time, and electromagnetic valve 42 is in opening all the time.
According to requirement of experiment repeat the above steps, the intermittent hypoxia environmental experiment of toy can be completed.

Claims (11)

1. a full-automatic control oxygen animal capsule is made up of nitrogen cylinder (1), air pump (5), animal capsule (4), surge tank (2), central processing unit (3), effusion meter (17), distributor (45), electromagnetic valve (15), electromagnetic valve (16), electromagnetic valve (42), pressure transducer (10), oxygen probe (11) and several conduit, cable etc.; It is characterized in that: animal capsule (4) is a hermetic container; Surge tank (2) is a spherical hollow container, and upper and lower Ge Kai is flatly; Distributor (45) is a joint blind pipe, two ends be provided with end socket (52), top is opened pipe joint of many steam vents (53) and constituted.
2. one according to claim 1 automatically controls oxygen animal capsule, it is characterized in that: animal capsule (4) top is provided with upper cover (61), upper cover (61) can be opened, built-in feedstuff dish (46) can place feedstuff in advance, external water supply bottle (41), introduce animal capsule (4) by conduit, be available for toy and drink.
3. one according to claim 1 automatically controls oxygen animal capsule, it is characterized in that: containing nitrogen in nitrogen cylinder (1), nitrogen cylinder (1) is connected with animal capsule (4) by rear end appendix (44) through effusion meter, rear end nitrogen conduit (13), front end delivery conduit (51), surge tank (2) by front end nitrogen conduit (12).
4. one according to claim 1 automatically controls oxygen animal capsule, it is characterised in that: air pump (5) is connected with animal capsule (4) by rear end appendix (44) through effusion meter (17), back air conduit (14), front end delivery conduit (51), surge tank (2) by front end air conduit (6).
5. one according to claim 1 automatically controls oxygen animal capsule, it is characterized in that: the control system that central processing unit (3) is whole device, it is responsible for the open and close of air pump (5), electromagnetic valve (15), electromagnetic valve (16), electromagnetic valve (42), is responsible for the process of animal capsule (4) interior pressure data and oxygen concentration data; In animal capsule (4) intrinsic pressure by pressure transducer (10) detect, oxygen concentration by oxygen probe (11) detect, they detection data send central processing unit (3) to; The time numerical value of intrinsic pressure data, oxygen concentration data and setting is that central processing unit (3) judges the basis that each functional part opens and closes.
6. one according to claim 1 automatically controls oxygen animal capsule, it is characterised in that: the opening on surge tank (2) top connects with rear end appendix (44), and the opening of bottom connects with front end appendix (51).
7. a kind of full-automatic control oxygen animal capsule according to claim 3,4, it is characterised in that: one end of rear end appendix (44) connects with surge tank (2), and the other end connects with distributor (45).
8. a kind of full-automatic control oxygen animal capsule according to claim 3,4, it is characterised in that: rear end nitrogen conduit (13), back air conduit (14) are connected with front end delivery conduit (51) by threeway;
One according to claim 1 automatically controls oxygen animal capsule, it is characterised in that: pressure transducer (10), oxygen probe (11) stretch in animal capsule (4), are fixed on upper cover (61).
9. one according to claim 2 automatically controls oxygen animal capsule, it is characterised in that: under any state, when animal capsule (4) intrinsic pressure is higher than setting value, electromagnetic valve (42) is opened, and steam vent (43) outwards discharges gas; Intrinsic pressure once reach setting value, that electromagnetic valve (42) reset and electromagnetic valve (42) control valve closing; Intrinsic pressure setting value can be equal to atmospheric value, it is also possible to lower than atmospheric value.
10. one according to claim 1 automatically controls oxygen animal capsule, it is characterised in that: one end of electromagnetic valve (42) is arranged in the adapter of upper cover (61), and the other end of free state constitutes steam vent (43).
11. a kind of full-automatic control oxygen animal capsule according to claim 1,3,4, it is characterized in that: front end air conduit (6), front end nitrogen conduit (12) are upper each equipped with effusion meter (17), and effusion meter (17) is provided with adjustment handle (19) and float (18).
CN201610057980.8A 2016-01-28 2016-01-28 Fully-automatic oxygen control animal tank Pending CN105662639A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105726156A (en) * 2016-05-06 2016-07-06 于兆衍 Obstructive sleep respiratory disorder disease animal model preparation system
CN106292805A (en) * 2016-09-22 2017-01-04 重庆鬼谷子医疗器械科技有限公司 A kind of digital intelligent oxygen generation system and control method
CN107126212A (en) * 2017-06-16 2017-09-05 中国科学院亚热带农业生态研究所 Intelligent animals respiratory metabolism determining system
CN108812410A (en) * 2018-07-04 2018-11-16 吕晋元 A kind of zoopery hyperbaric oxygen chamber
CN112790889A (en) * 2021-02-01 2021-05-14 成都森威实验动物有限公司 Preparation method and system of mixed gas for preparing intermittent hypoxia animal model
US20230097259A1 (en) * 2021-05-25 2023-03-30 The Academy Of Tianjin University, Hefei Generating device of simulating particulate environment for experimental animal

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CN203663626U (en) * 2013-11-08 2014-06-25 中国石油天然气股份有限公司 Air oxygen reduction device
CN104173119A (en) * 2014-08-27 2014-12-03 无锡菩禾生物医药技术有限公司 Intermittent hypoxia system
CN104287921A (en) * 2014-10-30 2015-01-21 王有存 Hyperbaric oxygen chamber oxygen supply and exhaust system
CN204324871U (en) * 2014-11-28 2015-05-13 浙江善时生物药械(商丘)有限公司 The device of fast lifting medical oxygen generator oxygen concentration

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CN202554160U (en) * 2012-04-19 2012-11-28 四川科伦药业股份有限公司 Self-control type animal experiment hypoxia chamber
CN203483519U (en) * 2013-09-23 2014-03-19 中国人民解放军成都军区总医院 Low-oxygen experiment cabin
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105726156A (en) * 2016-05-06 2016-07-06 于兆衍 Obstructive sleep respiratory disorder disease animal model preparation system
CN106292805A (en) * 2016-09-22 2017-01-04 重庆鬼谷子医疗器械科技有限公司 A kind of digital intelligent oxygen generation system and control method
CN106292805B (en) * 2016-09-22 2018-03-02 重庆鬼谷子医疗器械科技有限公司 A kind of digital intelligent oxygen generation system and control method
CN107126212A (en) * 2017-06-16 2017-09-05 中国科学院亚热带农业生态研究所 Intelligent animals respiratory metabolism determining system
CN108812410A (en) * 2018-07-04 2018-11-16 吕晋元 A kind of zoopery hyperbaric oxygen chamber
CN108812410B (en) * 2018-07-04 2021-09-24 吕晋元 Hyperbaric oxygen chamber for animal experiments
CN112790889A (en) * 2021-02-01 2021-05-14 成都森威实验动物有限公司 Preparation method and system of mixed gas for preparing intermittent hypoxia animal model
CN112790889B (en) * 2021-02-01 2024-07-02 四川大学华西医院 Mixed gas preparation method and system for intermittent anoxic animal model preparation
US20230097259A1 (en) * 2021-05-25 2023-03-30 The Academy Of Tianjin University, Hefei Generating device of simulating particulate environment for experimental animal

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