CN106137223B - The fully integrated bodily fluid sampling analyzer of single step - Google Patents
The fully integrated bodily fluid sampling analyzer of single step Download PDFInfo
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- CN106137223B CN106137223B CN201610665919.1A CN201610665919A CN106137223B CN 106137223 B CN106137223 B CN 106137223B CN 201610665919 A CN201610665919 A CN 201610665919A CN 106137223 B CN106137223 B CN 106137223B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150175—Adjustment of penetration depth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15149—Arrangement of piercing elements relative to each other
- A61B5/15151—Each piercing element being stocked in a separate isolated compartment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
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Abstract
The present invention provides a kind of fully integrated bodily fluid sampling analyzers of single step, comprising: shell integrates inspection portion of adopting, detection box, sensor, sealing film, upper cover, thief hatch, linear driving mechanism and control circuit；Wherein integrate and adopt inspection portion and integrated by miniature suction spindle, needle hub and the test strips of adopting, it is miniature adopt suction spindle and actively adopt inhale body fluid and be delivered directly to test strips, then be used to read the color change of test strips generation by sensor, acquisition and one step of detection are completed.The separation trough of sealing film and detection box forms the sealing reaction chamber of plural number；The linear driving mechanism is electrically connected at control circuit, and the integrated inspection portion of adopting of driving moves so that miniature blood taking needle is pierced into skin and reaches designated depth.The fully integrated bodily fluid sampling analyzer of single step of the present invention have it is small in size, it is high-efficient, operate conveniently, it is time-consuming short, save body fluid, be pierced into the advantages that depth is controllable, and measurement result is accurate and reliable.
Description
Technical field
The present invention relates to medical instruments, more particularly to a kind of fully integrated bodily fluid sampling analyzer of single step.
Background technique
Since the 1970s invents pocket body fluid analysis instrument, patient can be with self detecting blood sugar, rapid results.
With reference at present on the market carry blood glucose meter product, blood glucose measurement process is usually multiple step format process: patient firstly the need of with
Lancet punctures skin, is then directly applied to blood or is dripped on test paper with blood sampling device, is finally interpreted using blood glucose meter
Blood glucose value.Such test mode has blood sampling volume big, enables patient suffering, and component is various, the disadvantage of step complexity.In addition, with thorn
Blood needle separates the blood sugar test paper used, and accuracy is easy to be influenced by environmental factors such as such as temperature, humidity, chemical substances, try
Paper deposits in supercooling, overheat, excessively damp, contaminated environment or test paper and spends the shelf-life, can all influence the standard of surveyed blood glucose value
Exactness.
To solve the above problems, occurring All-in-One blood glucose meter in the market, sensor, blood sugar test paper and blood-taking device are set
It sets in a body, has certain improvement compared to traditional split-type blood glucose meter.But above-mentioned blood glucose meter is at work, blood
Sugared test paper and lancet are still the component of two autonomous workings, need first to puncture finger tip using lancet, then finger tip is close
Blood sugar test paper waits or squeezes wound perimeter, until blood volume is enough in blood sugar test paper, then waits the reagent on blood and test paper
It reacts, finally reads data via blood glucose meter.Operate in this way it is time-consuming and laborious, it is inconvenient.
In terms of the driving of lancet, the prior art is made that positive trial, and most common actuator is spring, for example
It is arcuately moved with torsional spring driving lancet and is pierced into and extracts to realize.But this driving is not linear, the depth of piercing
It is all uncertain with angle, and the depth being pierced into can not be preset, there are some potential safety problemss.
Take blood component take blood in terms of, the prior art relates to take blood with miniature similar hollow of suction spindle of adopting of the invention
Component, and the outlet end for taking blood component is directly connected with negative pressure device.However it is difficult by patient certainly using this connection type
Oneself repeats to realize thus practical degree is very low in daily survey blood glucose, used that blood component is taken not replace easily, can not use one
The plural detection unit detected in box realizes repeated detection.
In terms of sensor, blood glucose meter often uses electrochemistry and optical sensor, but there are precision for Conventional electrochemical sensor
Not enough and traditional optical sensor has that detection time is too long.If can accomplish that inspection single step is taken to complete and quickly obtain
Testing result, then optical sensor has apparent advantage and widely application in analyte detection field.
Summary of the invention
In view of the foregoing deficiencies of prior art, the purpose of the present invention is to provide a kind of fully integrated body fluid of single step to adopt
Sample analyzer, comprising: shell, the integrated of plural number adopt inspection portion, detection box, sensor, sealing film, upper cover, thief hatch, linear drive
Motivation structure, control circuit and back stitching spring；
It is described integrated to adopt inspection portion and integrated by miniature suction spindle, needle hub and the test strips of adopting；The miniature suction spindle of adopting is fixed on needle hub,
The test strips are embedded in needle hub lower surface, and the needle hub, which is provided with, holds the miniature through-hole adopting suction spindle and communicating with test strips, the collection
The portion Cheng Caijian is a plurality of and arranged radially in the detection box；
The miniature suction spindle of adopting is hollow microneedles, for puncturing skin and adopting suction body fluid, adopts the body fluid being drawn onto described in
The through-hole of needle hub is delivered directly to the test strips；The sensor is for reading due to body fluid is reacted with the reagent in test strips
The variation for generating test strips, acquisition and one step of detection are completed；
The sealing film is located at the upper and lower surface of the detection box, and the detection box is set along its multiple radial direction
Separation trough is set, the sealing film and each slot segmentation form the sealing reaction chamber of plural number；
Upper part of the housing is covered on described, the thief hatch is set on the upper lid, and the thief hatch is described micro- for holding
Type adopts suction spindle and is pierced by and draws back shell；
The linear driving mechanism is located at below the detection box, the control circuit is electrically connected at, for driving
Integrated inspection portion of adopting is stated to move so that miniature blood taking needle is pierced into skin；
The control circuit for control the linear driving mechanism and it is integrated adopts the movement of inspection portion, to control described miniature adopt
The depth specified under skin is reached when suction spindle samples；
The back stitching spring is set in each separation trough, for drawing back the miniature blood taking needle after sampling.
Preferably, the linear driving mechanism includes mandril and push rod spring,
The mandril be it is hollow, the mandril close to detection box one end be provided with side opening, for wearing out detection box in mandril
The inner cavity of connection mandril and the sealing reaction chamber after the sealing film of lower surface；
The mandril connects negative pressure device far from one end of detection box；
The push rod spring is used to draw back mandril in integrated adopt after suction body fluid is adopted in inspection portion；
It preferably, further include blocking ring component,
The blocking ring component includes blocking ring and blocking ring spring,
The blocking ring annular is wrapped in the mandril outer surface, for the mandril be driving it is integrated adopt the movement of inspection portion and
The breakage of film is sealed when wearing out detection box lower surface sealing film, to keep the sealing state of the sealing reaction chamber；
The blocking ring spring, which is used to compress blocking ring when the blocking ring seals at breakage of thin film applied, is close to film；
Preferably, the blocking ring is falope ring；
Preferably, the miniature overall diameter for adopting suction spindle is 50~500um；
Preferably, the sensor is optical sensor, for reading analyte and test strips in the body fluid taken
Reagent reaction generate readable optical signalling；
Complete the time needed from the one-time detection for sampling optical sensor generation result data in the integrated inspection portion of adopting
For 5-10s；
Preferably, the fully integrated bodily fluid sampling analyzer of single step of the present invention further includes sensor circuit, detected for incuding
Whether physical feeling is located at designated position；
Preferably, the detection box center is equipped with annular wall, and the shell is equipped with rotating member；
The annular wall is equipped with internal gear, and the rotating member is equipped with external gear, and the rotating member can pass through gear and institute
Detection box engagement is stated, to drive the detection box to rotate in the holding tank of shell；
Preferably, it is equipped with the guide frame protruded out in each separation trough, is provided with and the guide frame in the needle hub
The matched hole of shape, for keeping needle hub, along the guide frame longitudinal movement, to limit needle hub in separation trough in separation trough
Non-longitudinal displacement；
Preferably, the top surface of each separation trough is additionally provided with through-hole, passes through for holding the miniature suction spindle of adopting；
Preferably, the separation slot number is 2~50；
Preferably, the separation slot number is 10；
Preferably, the upper interior surface is additionally provided with magnet, and Magnetic Sensor is equipped in the shell, and upper cover lid closes Shi Suoshu
Tightly whether lid closes to detect the upper cover for Magnetic Sensor and the magnet magnetic connection；
It preferably, further include display screen, the display location is in casing upper half point, for showing analyte data；
Preferably, it is equipped at least one key beside the display screen, for allowing user's input control to instruct.
The fully integrated bodily fluid sampling analyzer of single step of the present invention using it is miniature adopt suction spindle, test strips and needle hub be integrated into it is integrated
Unique texture in each separation trough for being placed in detection box in inspection portion is adopted, miniature suction spindle of adopting actively adopts suction body fluid and is delivered directly to try
Paper slip, then analyte in the body fluid taken is read by optical sensor and reacts the readable optics generated with the reagent in test strips
Signal.Sampling, one step of detection are completed, and do not need to squeeze wound circumference or waiting long period after puncturing to acquire enough bodies
Liquid not only saves time of measuring, also saves body fluid, reduces patient suffering.The fully integrated bodily fluid sampling of single step of the present invention
The detection box of analyzer includes a plurality of separation troughs, and the interior placement of each separation trough one is integrated to adopt inspection portion, can be realized and repeatedly adopts
Detection part is replaced again after sample, detection, does not need frequently to replace, it is easy to use.Furthermore separation trough and sealing film of the invention
Negative reaction chamber is formed, keeps being in air-tight state in sampling and reaction process always with the help of sealed silicon rubber ring, make close
Envelope reaction chamber is able to help to adopt suction body fluid using negative pressure, further increases and adopts inspection efficiency.It finally but is not limited to, of the invention is miniature
It adopts suction spindle to be driven by linear driving mechanism, and Linear actuator is controlled by control circuit, it can be thick according to the different skin of patient
The miniature depth for adopting suction spindle piercing of degree adjustment, and the miniature suction spindle diameter of adopting of the present invention is minimum, accomplishes while ensure that sampling amount
Patient suffering minimized.In conclusion the fully integrated bodily fluid sampling analyzer of single step of the invention is small in size, it is high-efficient,
It operates conveniently, it is time-consuming short, body fluid is saved, piercing depth is controllable, and measurement result is accurate and reliable, meets patient and is bearing to minimize
The fast and accurate needs for measuring analyte content in body fluid under conditions of pain.
Detailed description of the invention
Fig. 1 is the stereoscopic schematic diagram of fully integrated one embodiment of bodily fluid sampling analyzer of single step of the present invention
Fig. 2 is the stereoscopic schematic diagram that the fully integrated bodily fluid sampling analyzer one of single step of the present invention detects box
Fig. 3 is the assembling schematic diagram of the fully integrated bodily fluid sampling analyzer detection box of single step of the present invention
Fig. 4 is the partial cutaway view of the fully integrated bodily fluid sampling analyzer of single step of the present invention
Fig. 5 is the stereoscopic schematic diagram of the fully integrated another embodiment of bodily fluid sampling analyzer of single step of the present invention
Fig. 6 is the decomposition diagram of the fully integrated another embodiment of bodily fluid sampling analyzer of single step of the present invention
Specific embodiment
To make the above purposes, features and advantages of the invention more obvious and understandable, with reference to the accompanying drawing to the present invention
Specific embodiment be described in detail.
Refering to fig. 1 and Fig. 2, the embodiment of a fully integrated bodily fluid sampling analyzer of single step of the present invention, including shell are provided
Body 1,1 upper surface of shell are equipped with upper cover 13, the holding tank 14 that can accommodate detection box 12 are equipped in shell 1, is equipped in holding tank 14
Can with the rotating member 202 that be meshed of internal gear in the annular wall 201 of detection box 12, be additionally provided on shell 1 display screen 16 and by
Key 17.Upper cover 13 is opened, detection box 12 can be put into holding tank 14 or take out from holding tank 14, after being put into, in annular wall 201
Internal gear can be engaged with the external gear on the rotating member 202 in holding tank 14, rotating member 202 drive detection box 12 in holding tank
It is circumferentially rotated in 14.After adopting inspection, the result data that sensor is read is equipped with several press on display screen 16 by display screen
Key 17, the input instruction of user's keys available 17.
Refering to Fig. 2 and Fig. 3, the present embodiment provides detection box 12 in a kind of present invention and the integrated fit systems for adopting inspection portion.
In the present embodiment, detection box 12 is radially equipped with ten separation troughs 15, and detection 12 center of box is equipped with annular wall 201,
On internal gear can be engaged with the external gear on the rotating member 202 in shell holding tank with realize detection box 12 in holding tank 14
Rotation.Each separation trough top surface is provided with through-hole 112, holds miniature suction spindle of adopting and is pierced by detection box 12 in sampling and completes in sampling
After draw back detection box 12.It is additionally provided with the guide frame 301 protruded out in each separation trough 15, is provided in the integrated needle hub 3 for adopting inspection portion
With the matched hole 302 of 301 shape of guide frame, for keeping needle hub 3 longitudinal along the guide frame 301 in separation trough 15
Movement limits non-longitudinal displacement of the needle hub 3 in separation trough 15, to guarantee the control to the miniature motion path for adopting suction spindle 2.
Refering to Fig. 3 and Fig. 4, the present embodiment provides detect box 12 in a kind of present invention, miniature adopt 2 needle hub of suction spindle, 3 test strips 4
The integrated integrated assembly method for adopting inspection portion and lower sealing film 102.Miniature suction spindle 2 of adopting is fixed on needle by fixed structure
On hub 3, test strips 4 are embedded in 3 lower surface of needle hub, are provided in needle hub 3 and hold the miniature through-hole adopting suction spindle 2 and communicating with test strips 4, needle
It is also provided on hub 3 and the matched hole 302 of 301 shape of guide frame in separation trough 15.Each integrated inspection portion of adopting miniature is adopted by one
2 one needle hub of suction spindle, 3 one test strips 4 are integrated, and each integrated inspection portion of adopting is assemblied in each separation trough 15 of detection box 12.It has assembled
Cheng Hou seals the lower surface of detection box 12 with lower sealing film 102, and upper sealing film 101 seals detection 12 upper surface of box, makes each
A separation trough 15 forms the sealing reaction chamber of plural number with lower films.
Refering to fig. 1 to Fig. 4, the present embodiment provides a kind of integrated driving methods for adopting inspection portion of present invention.It is miniature to adopt 2 needle of suction spindle
3 test strips 4 of hub be integrated into it is integrated adopts inspection portion, in the separation trough 15 of detection box 12, be provided with to hold in needle hub 3 and miniature adopt suction spindle 2
The through-hole 111 communicated with test strips 4 is additionally provided with back stitching spring 7 in each separation trough 15, is located at detection 12 top surface of box and needle hub 3
Between.Sealing film 101 and 102 seals the upper and lower surface of detection box 12 respectively, and the sealing for forming plural number with separation trough 15 is reacted
Chamber.Optical sensor 5 is set in shell 1, and 12 lower section of detection box, thief hatch 6 is set in upper cover 13.
In the present embodiment, for drive it is integrated to adopt the linear driving mechanism in inspection portion include mandril 8 and push rod spring 9, be located at
In shell 1,12 lower section of detection box.In the present embodiment, mandril 8 is hollow stem, and mandril 8 is provided with side close to one end of detection box 12
Hole, mandril 8 connect negative pressure device far from one end of detection box 12, and mandril 8 is nearby additionally provided with push rod spring 9.In the present embodiment, shell
Blocking ring component is additionally provided in body 1 comprising blocking ring 10 and blocking ring spring 11,10 annular of blocking ring are wrapped in 8 outer surface of mandril,
11 upper end of blocking ring spring connects blocking ring 10, and lower end connects mandril 8.Mandril 8 is electrically connected at a control circuit.
When sampling, mandril 8 moves upwards under the control of the control circuit, wears out the transparent lower sealing in detection 12 lower surface of box
The following table face contact of film 102 and needle hub 3 and push it is entire it is integrated adopt inspection portion and move upwards, push rod spring 9 and back stitching bullet at this time
Spring 7 comes compressive state from original state.Miniature suction spindle 2 of adopting is adopted inspection portion and is moved upwards with integrated, wears out detection 12 upper surface of box
Sealing film 101 and the thief hatch 6 being pierced by upper cover 13, finally puncture human skin.When miniature suction spindle 2 of adopting reaches subcutaneous specify
Depth when, control circuit control mandril 8 does not continue to upwards, integrated at this time to adopt the yet stop motion of inspection portion.Mandril 8 moves upwards
In the process, blocking ring 10 is moved upwards with mandril 8, and blocking ring spring 11 is in original state.Under 8 bursting of mandril after sealing film 102,
Blocking ring 10 contacts with lower sealing film 102 and blocks the breakage of lower sealing film 102 around mandril 8.Blocking ring 10 is close under
After sealing film 102 contacts, mandril 8 moves further up, and blocking ring spring 11 is compressed at this time, by blocking ring 10 in lower sealing film
It is compressed on 102.It is miniature adopt suction spindle 2 and move upwards can also puncture sealing film 101, but the diameter of needle is very small, 50
Between~500um, so the upper sealing film 101 around needle is not in breakage.Due to the breakage of lower sealing film 102
It is blocked by blocking ring 10, the sealing reactive tank that separation trough 15 and sealing film 101,102 are constituted is maintained sealing state.
Miniature when adopting suction spindle 2 and reaching subcutaneous designated depth, the side opening on mandril 8 is located at lower 102 top of sealing film, sealing
In reaction chamber, so that the inner cavity of mandril 8 is connected to sealing reaction chamber.Negative pressure device forms negative pressure in the inner cavity of mandril 8, because of mandril
8 inner cavity is connected to sealing reaction chamber, is sealed in reaction chamber and is also formed negative pressure.Miniature suction spindle 2 of adopting is hollow micro- in the present embodiment
Needle, therefore the inner cavity of hollow microneedles also forms negative pressure, and hollow microneedles is helped actively to adopt suction body fluid after puncturing skin.
After the body fluid for acquiring enough detections, the miniature body fluid adopted in suction spindle 2 is directly transported by the through-hole 111 in needle hub 3
In the test strips 4 of 3 lower surface of needle hub, the analyte in body fluid reacts with the reagent in test strips 4 for inset, produces test strips 4
Raw color change.This color change is read as the optical sensor 5 that readable optical signalling is detected 12 lower section of box, and raw
It is finally shown on display screen 16 at corresponding result data.It samples one step of detection to complete, only needs 5-10s, and in the process not
User is needed to make intervention action.
When sampling, mandril 8 moves upwards under the control of the control circuit, and push rod spring 9 is in compressive state；It is integrated to adopt inspection
Portion is pushed up by mandril 8, and back stitching spring 7 is also at compressive state.When it is miniature adopt suction spindle 2 and reach subcutaneously specified depth when,
Control circuit control mandril 8 stops, and the push rod spring 9 for being now in compressive state has the needs for replying initial position, release
Mandril 8 is drawn back its initial position by tension.During mandril 8 is drawn back, 11 tension of blocking ring spring of compressive state is discharged and is replied
Blocking ring 10 is no longer pressed on lower sealing film 102 by original state.After sampling, back stitching spring 7 is also replied just from compressive state
The tension of beginning state, release draws back miniature suction spindle 2 of adopting in shell 1.
After once adopting inspection, detection box 12 rotates the circumferential distance of a separation trough, and it is standby in place that newly integrated adopts inspection portion.This
It includes ten separation troughs 15 that box 12 is detected in embodiment altogether, and corresponding ten corresponding integrate adopt inspection portion, it can complete ten inspections
It surveys.User again can replace detection box 12 after completing ten detections, easy to use.
Refering to Fig. 5, in the present embodiment, 13 inner surface of upper cover is equipped with whether an induction physical feeling to be measured is in specific bit
The sensor circuit 401 set, is additionally provided with connector 402 in shell 1, and contact is simultaneously when the upper cover 13 is covered and closed for the connector 402
It is electrically connected the sensor circuit 401, the connector 402 is electrically connected to the control circuit of control linear driving mechanism simultaneously.This
In embodiment, connector 402 is pogo pin, and when upper cover 13, which is covered, closes, the plain conductor of the sensor circuit 401 is pressed in flexible
On probe, realization is electrically connected with control circuit, and sensor circuit 401 can be sent out when sensing a certain physical feeling at this time
Electric signals control linear driving mechanism to control circuit and miniature suction spindle 2 of adopting are driven to be pierced by 6 collection of body fluids of thief hatch.
Refering to Fig. 6, in the present embodiment, 13 inner surface of upper cover is equipped with the magnet holding tank 503 for containing magnet 501, institute
The Magnetic Sensor 502 for corresponding to the magnet 501 in shell 1 equipped with position is stated, the Magnetic Sensor 502 may be coupled to the control
Circuit processed.Magnetic Sensor 502 can detect magnet 501 when upper cover 13 is closed, and when opening can't detect magnet 501, be judged with this
Tightly whether lid closes the upper cover 13.
Although present disclosure is as above, present invention is not limited to this.Anyone skilled in the art are not departing from this
It in the spirit and scope of invention, can make various changes or modifications, therefore protection scope of the present invention should be with claim institute
Subject to the range of restriction.
Claims (12)
1. a kind of fully integrated bodily fluid sampling analyzer of single step, comprising:
Shell, the integrated of plural number adopt inspection portion, detection box, sensor, sealing film, upper cover, thief hatch, linear driving mechanism, control
Circuit processed and back stitching spring；
It is characterized in that,
It is described integrated to adopt inspection portion and integrated by miniature suction spindle, needle hub and the test strips of adopting；The miniature suction spindle of adopting is fixed on needle hub, described
Test strips are embedded in needle hub lower surface, and the needle hub, which is provided with, holds the miniature through-hole adopting suction spindle and communicating with test strips, and described integrate is adopted
Inspection portion is a plurality of and arranged radially in the detection box；
The miniature suction spindle of adopting is that hollow microneedles adopt the body fluid being drawn onto and pass through the needle hub for puncturing skin and adopting suction body fluid
Through-hole be delivered directly to the test strips；The sensor is for reading caused by body fluid reacts with the reagent in test strips
Reaction information, acquisition and one step of detection are completed；
The sealing film is located at the upper and lower surface of the detection box, and the detection box is along its multiple radial direction setting point
Separate slot, the sealing film and the separation trough form the sealing reaction chamber of plural number；
It is covered on upper part of the housing on described, the thief hatch is set on the upper lid, and the thief hatch is for holding described miniature adopt
Suction spindle is pierced by and draws back shell；
The linear driving mechanism is located at below the detection box, the control circuit is electrically connected at, for driving the collection
The portion Cheng Caijian moves so that miniature blood taking needle is pierced into skin；
The control circuit for control the linear driving mechanism and it is integrated adopts the movement of inspection portion, described miniature adopt suction spindle to control
The depth specified under skin is reached when sampling；
The back stitching spring is set in each separation trough, for drawing back the miniature blood taking needle after sampling；
The linear driving mechanism includes mandril and push rod spring,
The mandril be it is hollow, the mandril close to detection box one end be provided with side opening, for mandril wear out detection box following table
The inner cavity of connection mandril and the sealing reaction chamber after the sealing film of face；
The mandril connects a negative pressure device far from one end of detection box；
The push rod spring is used to draw back mandril in integrated adopt after suction body fluid is adopted in inspection portion.
2. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that further include blocking ring group
Part,
The blocking ring component includes blocking ring and blocking ring spring,
The blocking ring annular is wrapped in the mandril outer surface, adopts the movement of inspection portion for being that driving is integrated in the mandril and wears out
The breakage of film is sealed when detecting box lower surface sealing film, to keep the sealing state of the sealing reaction chamber；
The blocking ring spring, which is used to compress blocking ring when the blocking ring seals at breakage of thin film applied, is close to film.
3. the fully integrated bodily fluid sampling analyzer of single step according to claim 2, which is characterized in that
The blocking ring is falope ring.
4. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
The miniature overall diameter for adopting suction spindle is 50~500um.
5. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
The sensor is optical sensor, reacts production with the reagent in test strips for reading the analyte in the body fluid taken
Raw readable optical signalling.
6. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
It further include sensor circuit, the sensor circuit is for incuding whether detected physical feeling is located at designated position.
7. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
The detection box center is equipped with annular wall, and the shell is equipped with rotating member；
The annular wall is equipped with internal gear, and the rotating member is equipped with external gear, and the rotating member can pass through gear and the inspection
Box engagement is surveyed, to drive the detection box to rotate in the holding tank of shell.
8. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
It is equipped with the guide frame protruded out in each separation trough, is provided in the needle hub matched with the guide frame shape
Hole, for keeping needle hub, along the guide frame longitudinal movement, to limit non-longitudinal position of the needle hub in separation trough in separation trough
It moves；
The top surface of each separation trough is additionally provided with through-hole, passes through for holding the miniature suction spindle of adopting.
9. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
The separation slot number is 2~50.
10. the fully integrated bodily fluid sampling analyzer of single step according to claim 9, which is characterized in that
The separation slot number is 10.
11. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
The upper interior surface is additionally provided with magnet, is equipped with Magnetic Sensor in the shell, upper cover lid when closing the Magnetic Sensor with
To detect the upper cover, tightly whether lid closes the magnet magnetic connection.
12. the fully integrated bodily fluid sampling analyzer of single step according to claim 1, which is characterized in that
It further include display screen, the display location is in casing upper half point, for showing result data；It is set beside the display screen
There is at least one key, for allowing user's input control to instruct.
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| CN201610665919.1A CN106137223B (en) | 2016-08-12 | 2016-08-12 | The fully integrated bodily fluid sampling analyzer of single step |
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| CN106137223B true CN106137223B (en) | 2019-04-26 |
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Families Citing this family (5)
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| EP3496614B1 (en) * | 2016-08-12 | 2022-04-06 | Medtrum Technologies Inc. | A one step all in one apparatus for body fluid sampling and sensing |
| CN107874767B (en) * | 2017-10-12 | 2020-11-24 | 杭州博拓生物科技股份有限公司 | Device for detecting analyzed substance in sample |
| CN111134636A (en) * | 2018-11-05 | 2020-05-12 | 巧连科技股份有限公司 | Physiology detection module and wearable electronic device with same |
| CN109932404A (en) * | 2019-03-25 | 2019-06-25 | 上海交通大学医学院附属上海儿童医学中心 | A kind of online body fluid detection device and baby's oral secretion on-line measuring device |
| CN113391071B (en) * | 2021-07-29 | 2024-04-30 | 宁波康和生物科技有限公司 | Blood sampling detects integral type blood glucose meter based on self-adaptation blood volume detection technique |
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