CN106137223A - Single step fully integrated bodily fluid sampling analyser - Google Patents
Single step fully integrated bodily fluid sampling analyser Download PDFInfo
- Publication number
- CN106137223A CN106137223A CN201610665919.1A CN201610665919A CN106137223A CN 106137223 A CN106137223 A CN 106137223A CN 201610665919 A CN201610665919 A CN 201610665919A CN 106137223 A CN106137223 A CN 106137223A
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- China
- Prior art keywords
- single step
- bodily fluid
- detection box
- push rod
- miniature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150175—Adjustment of penetration depth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15149—Arrangement of piercing elements relative to each other
- A61B5/15151—Each piercing element being stocked in a separate isolated compartment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
Abstract
The invention provides a kind of single step fully integrated bodily fluid sampling analyser, including: housing, integrated adopt inspection portion, detection box, sensor, sealing film, upper cover, thief hatch, linear driving mechanism and control circuit；The most integrated inspection portion of adopting is integrated by miniature suction spindle, needle hub and the test strips of adopting, and miniature suction spindle of adopting actively is adopted suction body fluid and is delivered directly to test strips, then the color change produced for reading test strips by sensor, gathers and detects a step and complete.Sealing film forms plural sealing reaction chamber with the separation trough of detection box；Described linear driving mechanism is electrically connected at control circuit, drives integrated inspection portion of adopting to move so that miniature blood taking needle thrusts skin and arrives designated depth.It is little that single step of the present invention fully integrated bodily fluid sampling analyser has volume, and efficiency is high, and operation is convenient, the shortest, saves body fluid, and it is controlled to thrust the degree of depth, the measurement result advantage such as accurately and reliably.
Description
Technical field
The present invention relates to medical apparatus and instruments, particularly relate to a kind of single step fully integrated bodily fluid sampling analyser.
Background technology
Since 20 century 70s invent pocket body fluid analysis instrument, patient can be with self detecting blood sugar, rapid results.
With reference at present portability blood glucose meter product the most on the market, blood glucose measurement process is typically multiple step format process: patient firstly the need of with
Lancet punctures skin, is then directly applied to by blood or drips on reagent paper with blood sampler, finally utilizing blood glucose meter to understand
Blood glucose value.Such test mode has blood sampling volume big, makes patient suffering, and parts are various, the shortcoming that step is complicated.Additionally, with thorn
Blood pin separates the blood sugar test paper used, and its accuracy is easily affected by such as the environmental factorss such as temperature, humidity, chemical substance, examination
Supercool, overheated, excessively damp, contaminated environment deposited in by paper, or the shelf-life spent by reagent paper, all can affect the standard of surveyed blood glucose value
Exactness.
For solving the problems referred to above, market occurs in that All-in-One blood glucose meter, sensor, blood sugar test paper and blood device are set
Put in a body, have certain improvement compared to traditional split-type blood glucose meter.But, above-mentioned blood glucose meter operationally, blood
Sugar reagent paper and lancet remain two parts worked alone, and need first to use lancet to puncture finger tip, then finger tip is close
Blood sugar test paper, waits or extrudes wound perimeter, until blood volume is enough in blood sugar test paper, then waits blood and the reagent on reagent paper
React, finally read data via blood glucose meter.So operation is wasted time and energy, operation inconvenience.
In terms of the driving of lancet, prior art is made that positive trial, the most frequently used actuator are springs, such as
Lancet is driven arcuately to move to realize thrusting and extracting with torsion spring.But this driving is not the degree of depth that is linear, that thrust
The most uncertain with angle, and the degree of depth thrust cannot preset, and there is certain potential safety hazard.
Take blood parts take blood in terms of, the miniature hollow adopting suction spindle similar that prior art relates to the present invention takes blood
Parts, and the port of export taking blood parts is directly connected with negative pressure device.But use this connected mode to be difficult to by patient certainly
Oneself repeat realize thus in daily survey blood glucose practical degree the lowest, the used blood parts that take cannot be changed easily, it is impossible to one
Plural detector unit in detection box realizes repeated detection.
In terms of sensor, blood glucose meter commonly uses electrochemistry and optical pickocff, but Conventional electrochemical sensor exists precision
The problem that traditional optical sensor exists detection overlong time not.If can accomplish that taking inspection single step completes and quickly obtain
Testing result, then optical pickocff has obvious advantage and wider application in detection of analytes field.
Summary of the invention
The shortcoming of prior art in view of the above, it is an object of the invention to provide a kind of fully integrated body fluid of single step and adopts
Sample analyser, including: housing, integrated the adopting inspection portion, detection box, sensor, sealing film, upper cover, thief hatch, linearly drive of plural number
Motivation structure, control circuit and back stitching spring；
Described integrated adopt inspection portion to adopt suction spindle, needle hub and test strips integrated by miniature；Described miniature suction spindle of adopting is fixed on needle hub,
Described test strips is embedded in needle hub lower surface, and described needle hub has appearance and miniature adopts the through hole that suction spindle communicates with test strips, described collection
Cheng Caijian portion is a plurality of and arranged radially is in described detection box；
Described miniature suction spindle of adopting is hollow microneedles, is used for puncturing skin and adopting suction body fluid, adopts the body fluid being drawn onto by described
The through hole of needle hub is delivered directly to described test strips；Described sensor is for reading because of the reagent reacting on body fluid and test strips
Make the change that test strips produces, gather and detect a step and complete；
Described sealing film lays respectively at the upper and lower surface of described detection box, and described detection box sets along its multiple radial direction
Putting separation trough, described sealing film and each slot segmentation described form the sealing reaction chamber of plural number；
Being covered on housing upper on described, described thief hatch is located on described and is covered, and described thief hatch is used for holding described micro-
Type is adopted suction spindle and is passed and draw back housing；
Described linear driving mechanism is positioned at below described detection box, is electrically connected at described control circuit, is used for driving institute
State integrated inspection portion of adopting to move so that miniature blood taking needle thrusts skin；
Described control circuit is used for controlling described linear driving mechanism and integrated adopts the motion of inspection portion, to control described miniature adopt
Arrive, during suction spindle sampling, the degree of depth specified under skin；
Described back stitching spring is located in described each separation trough, is drawn back by described miniature blood taking needle after sampling.
Preferably, described linear driving mechanism includes push rod and push rod spring,
Described push rod is hollow, and described push rod has side opening near one end of detection box, for wearing out detection box at push rod
The inner chamber of push rod and described sealing reaction chamber is connected after lower surface sealing film；
Described push rod connects negative pressure device away from one end of detection box；
Described push rod spring is for drawing back push rod integrated adopting after suction body fluid is adopted in inspection portion；
Preferably, also include stifled ring assemblies,
Described stifled ring assemblies includes stifled ring and stifled ring spring,
Described stifled ring annular is wrapped in described push rod outer surface, for described push rod for drive integrated adopt inspection portion motion and
The breakage of thin film is sealed, to keep the sealing state of described sealing reaction chamber when wearing out detection box lower surface sealing film；
Described stifled ring spring compresses stifled ring at described stifled ring seal firmly breakage of thin film applied time and is close to thin film；
Preferably, described stifled ring is falope ring；
Preferably, the described miniature overall diameter adopting suction spindle is 50～500um；
Preferably, described sensor is optical pickocff, for reading the analyte in the body fluid taked and test strips
Reagent reacting produce readable optical signalling；
Described integrated inspection portion of adopting completes from sampling the time that optical pickocff generates the one-time detection needs of result data
It is 5 10s；
Preferably, single step of the present invention fully integrated bodily fluid sampling analyser also includes sensor circuit, is used for sensing detected
Whether body part is positioned at appointment position；
Preferably, described detection box center is provided with annular wall, and described housing is provided with tumbler；
Described annular wall is provided with internal gear, and described tumbler is provided with external gear, and described tumbler can pass through gear and institute
State detection box engagement, to drive described detection box to rotate in the holding tank of housing；
Preferably, in described each separation trough, it is provided with the guide frame protruded out, described needle hub has and described guide frame
The hole of form fit, is used for keeping needle hub along described guide frame lengthwise movement in separation trough, limits needle hub in separation trough
Non-longitudinal displacement；
Preferably, the end face of described each separation trough is additionally provided with through hole, is used for holding described miniature suction spindle of adopting and passes through；
Preferably, described separation trough quantity is 2～50；
Preferably, described separation trough quantity is 10；
Preferably, described upper interior surface is additionally provided with Magnet, is provided with Magnetic Sensor, described in when upper cover covers in described housing
Magnetic Sensor be connected with described magnet magnetic force with detect described upper cover the most tightly cover；
Preferably, also include that display screen, described display location divide in casing upper half, be used for showing analyte data；
Preferably, described display screen side is provided with at least one button, is used for allowing user input control instruction.
Single step of the present invention fully integrated bodily fluid sampling analyser uses miniature suction spindle, test strips and the needle hub of adopting to be integrated into integrated
Unique texture in each separation trough being placed in detection box in inspection portion, miniature suction spindle of adopting actively is inhaled body fluid and is delivered directly to examination
Paper slip, then read, by optical pickocff, the readable optics that analyte and the reagent reacting in test strips in the body fluid taked produce
Signal.Sampling, detect a step and complete, it is not necessary to extrude wound circumference or waiting long period after puncturing to gather enough bodies
Liquid, not only saves the measurement time, also saves body fluid, reduce patient suffering.The fully integrated bodily fluid sampling of single step of the present invention
The detection box of analyser comprises a plurality of separation trough, places an integrated inspection portion, it is possible to realize repeatedly in each separation trough
Detection part is changed again, it is not necessary to frequently change after sample, detection, easy to use.Furthermore, the separation trough of the present invention and sealing film
Form negative reaction chamber, keep sampling and course of reaction are in air-tight state all the time with the help of sealing falope ring, make close
Envelope reaction chamber is utilized negative pressure to help to adopt suction body fluid, improves further and adopts inspection efficiency.Last but be not limited to, the present invention's is miniature
Adopt suction spindle to be driven by linear driving mechanism, and controlled Linear actuator by control circuit, can be thick according to the skin that patient is different
Degree adjusts miniature adopts the degree of depth that suction spindle thrusts, and the present invention is miniature, and to adopt suction spindle diameter minimum, it is ensured that accomplish while sampling amount
Patient suffering minimized.In sum, the single step fully integrated bodily fluid sampling analyser volume of the present invention is little, and efficiency is high,
Operation is convenient, the shortest, saves body fluid, and it is controlled to thrust the degree of depth, and measurement result accurately and reliably, meets patient and minimizes bearing
The needs of analyte content in measurement body fluid fast and accurate under conditions of misery.
Accompanying drawing explanation
Fig. 1 is the schematic perspective view of single step of the present invention fully integrated bodily fluid sampling analyser one embodiment
Fig. 2 is the schematic perspective view that single step of the present invention fully integrated bodily fluid sampling analyser one detects box
Fig. 3 is the assembling schematic diagram of single step of the present invention fully integrated bodily fluid sampling analyser detection box
Fig. 4 is the part sectioned view of single step of the present invention fully integrated bodily fluid sampling analyser
Fig. 5 is the schematic perspective view of single step of the present invention fully integrated bodily fluid sampling another embodiment of analyser
Fig. 6 is the decomposing schematic representation of single step of the present invention fully integrated bodily fluid sampling another embodiment of analyser
Detailed description of the invention
Understandable, below in conjunction with the accompanying drawings to the present invention for enabling the above-mentioned purpose of the present invention, feature and advantage to become apparent from
Specific embodiment be described in detail.
Refering to Fig. 1 and Fig. 2, it is provided that the embodiment of a single step of the present invention fully integrated bodily fluid sampling analyser, including shell
Body 1, housing 1 upper surface is provided with upper cover 13, is provided with the holding tank 14 that can accommodate detection box 12, is provided with in holding tank 14 in housing 1
Can with the tumbler 202 that be meshed of internal gear in the annular wall 201 of detection box 12, housing 1 is additionally provided with display screen 16 and by
Key 17.Opening upper cover 13, detection box 12 can be put into holding tank 14 or take out, after putting into, in its annular wall 201 from holding tank 14
Internal gear can engage with the external gear on the tumbler 202 in holding tank 14, tumbler 202 drive detection box 12 at holding tank
In 14 circumferentially rotated.After adopting inspection, sensor read result data on display screen 16, be provided with by display screen several by
Key 17, user's keys available 17 input instruction.
Refering to Fig. 2 and Fig. 3, the present embodiment provides and detects box 12 and the integrated fit system adopting inspection portion in a kind of present invention.
In the present embodiment, detection box 12 is radially provided with ten separation troughs 15, and detection box 12 center is provided with annular wall 201, its
On internal gear can engage with the external gear on the tumbler 202 in housing holding tank with realize detection box 12 in holding tank 14
Rotation.Each separation trough end face has through hole 112, holds miniature suction spindle of adopting and passes detection box 12 when sampling and complete in sampling
After draw back detection box 12.It is additionally provided with the guide frame 301 protruded out in each separation trough 15, the integrated needle hub 3 adopting inspection portion has
With the hole 302 of this guide frame 301 form fit, it is used for keeping needle hub 3 longitudinal along described guide frame 301 in separation trough 15
Motion, limits the needle hub 3 non-longitudinal displacement in separation trough 15, to ensure the control to the miniature motion path adopting suction spindle 2.
Refering to Fig. 3 and Fig. 4, the present embodiment provides and detects box 12 in a kind of present invention, miniature adopts suction spindle 2 needle hub 3 test strips 4
The integrated integrated assembling mode adopting inspection portion and lower seal thin film 102.Miniature suction spindle 2 of adopting is fixed on pin by fixed structure
On hub 3, test strips 4 is embedded in needle hub 3 lower surface, needle hub 3 has appearance and miniature adopts the through hole that suction spindle 2 communicates with test strips 4, pin
Also have on hub 3 and the hole 302 of guide frame 301 form fit in separation trough 15.Each integrated inspection portion of adopting miniature is adopted by one
Suction spindle 2 one needle hub 3 one test strips 4 is integrated, and each integrated inspection portion of adopting is assemblied in each separation trough 15 detecting box 12.Assemble
Cheng Hou, seals the lower surface of detection box 12 with lower seal thin film 102, and upper sealing film 101 seals detection box 12 upper surface, makes each
Individual separation trough 15 and lower films form the sealing reaction chamber of plural number.
Refering to Fig. 1 to Fig. 4, the present embodiment provides the integrated type of drive adopting inspection portion of a kind of present invention.Miniature adopt suction spindle 2 pin
Hub 3 test strips 4 is integrated into integrated adopts inspection portion, is positioned at the separation trough 15 of detection box 12, needle hub 3 has appearance is miniature adopts suction spindle 2
The through hole 111 communicated with test strips 4, is additionally provided with back stitching spring 7 in each separation trough 15, is positioned at detection box 12 end face and needle hub 3
Between.Sealing film 101 and 102 seals the upper and lower surface of detection box 12 respectively, and the sealing forming plural number with separation trough 15 is reacted
Chamber.Optical pickocff 5 is located in housing 1, and below detection box 12, thief hatch 6 is located on upper cover 13.
In the present embodiment, for driving the integrated linear driving mechanism adopting inspection portion to include push rod 8 and push rod spring 9, it is positioned at
In housing 1, below detection box 12.In the present embodiment, push rod 8 is hollow bar, and push rod 8 has side near one end of detection box 12
Hole, push rod 8 connects negative pressure device away from one end of detection box 12, is additionally provided with push rod spring 9 near push rod 8.In the present embodiment, shell
Being additionally provided with stifled ring assemblies in body 1, it includes that stifled ring 10 and stifled ring spring 11, stifled ring 10 annular are wrapped in described push rod 8 outer surface,
Stifled ring spring 11 upper end connects stifled ring 10, and lower end connects push rod 8.Push rod 8 is electrically connected at a control circuit.
During sampling, push rod 8 moves upward under the control of control circuit, wears out the lower seal that detection box 12 lower surface is transparent
Thin film 102 contacts with the lower surface of needle hub 3 and promotes whole integrated inspection portion of adopting to move upward, now push rod spring 9 and back stitching bullet
Spring 7 comes compressive state from original state.Miniature suction spindle 2 of adopting moves upward with integrated inspection portion of adopting, and wears out detection box 12 upper surface
Sealing film 101 also passes the thief hatch 6 on upper cover 13, finally punctures human body skin.When miniature suction spindle 2 of adopting arrives subcutaneous appointment
The degree of depth time, control circuit controls push rod 8 and does not continues to upwards, the most integrated adopts the also stop motion of inspection portion.Push rod 8 moves upward
During, stifled ring 10 moves upward with push rod 8, and stifled ring spring 11 is in original state.After push rod 8 bursting lower seal thin film 102,
Stifled ring 10 contacts with lower seal thin film 102 and blocks the breakage of push rod 8 surrounding lower seal thin film 102.Stifled ring 10 with under close
After sealing film 102 contact, push rod 8 moves further up, now blocks up ring spring 11 and is compressed, by stifled ring 10 at lower seal thin film
Compress on 102.Miniature suction spindle 2 of adopting moves upward and also can puncture sealing film 101, but the diameter of pin is the most small, 50
～between 500um, so can't there is breakage in the upper sealing film 101 around pin.Breakage due to lower seal thin film 102
The ring 10 that is blocked blocks, and the sealing reactive tank that separation trough 15 is constituted with sealing film 101,102 is maintained sealing state.
Miniature suction spindle 2 of adopting is when arriving subcutaneous designated depth, and the side opening on push rod 8 is positioned at above lower seal thin film 102, seals
In reaction chamber so that the inner chamber of push rod 8 connects with sealing reaction chamber.Negative pressure device forms negative pressure, because of push rod at the inner chamber of push rod 8
The inner chamber of 8 connects with sealing reaction chamber, also forms negative pressure in sealing reaction chamber.In the present embodiment, miniature suction spindle 2 of adopting is that hollow is micro-
Pin, therefore the inner chamber of hollow microneedles also forms negative pressure, helps hollow microneedles actively to adopt suction body fluid after puncturing skin.
After gathering the body fluid of enough detections, the miniature body fluid adopted in suction spindle 2 is directly carried by the through hole 111 in needle hub 3
Inset, at the test strips 4 of needle hub 3 lower surface, the analyte in body fluid and the reagent reacting in test strips 4, makes test strips 4 produce
Raw color change.The optical pickocff 5 that the change of this color is detected below box 12 as readable optical signalling reads, and raw
Corresponding result data is become finally to be shown on display screen 16.Sample detection one step to complete, only need 5 10s, and during not
User is needed to make intervention action.
During sampling, push rod 8 moves upward under the control of control circuit, and push rod spring 9 is in compressive state；Integrated adopt inspection
By push rod 8 upwardly, back stitching spring 7 is also at compressive state in portion.When miniature adopt suction spindle 2 arrive the subcutaneous degree of depth specified time,
Control circuit controls push rod 8 and stops, and the push rod spring 9 being now in compressive state has the needs replying initial position, release
Push rod 8 is drawn back its initial position by tension force.During push rod 8 is drawn back, stifled ring spring 11 release of tension of compressive state is also replied
Original state, is no longer pressed on stifled ring 10 on lower seal thin film 102.After sampling, back stitching spring 7 is also at the beginning of compressive state is replied
Beginning state, miniature suction spindle 2 of adopting is drawn back in housing 1 by the tension force of release.
After once adopting inspection, detection box 12 rotates the circumferential distance of a separation trough, and new integrated to adopt inspection portion in place standby.This
Embodiment detects box 12 and includes ten separation troughs 15, corresponding ten corresponding integrated inspection portions of adopting altogether, i.e. can complete ten inspections
Survey.Detection box 12 can be replaced after completing ten detections by user again, easy to use.
Refering to Fig. 5, in the present embodiment, upper cover 13 inner surface is provided with whether a sensing body part to be measured is in specific bit
The sensor circuit 401 put, is additionally provided with adapter 402 in housing 1, described adapter 402 contacts also when described upper cover 13 covers
Electrically connecting described sensor circuit 401, described adapter 402 is electrically connected to control the control circuit of linear driving mechanism simultaneously.This
In embodiment, adapter 402 is pogo pin, and when upper cover 13 covers, the plain conductor of described sensor circuit 401 is pressed in flexible
On probe, it is achieved with the electric connection of control circuit, now sensor circuit 401 just can be sent out when sensing a certain body part
Electric signals drives miniature suction spindle 2 of adopting to pass thief hatch 6 collection of body fluids to control circuit to control linear driving mechanism.
Refering to Fig. 6, in the present embodiment, upper cover 13 inner surface is provided with the Magnet holding tank 503 containing Magnet 501, institute
Being provided with the Magnetic Sensor 502 of the corresponding described Magnet 501 in position in stating housing 1, described Magnetic Sensor 502 may be coupled to described control
Circuit processed.When upper cover 13 closes, Magnetic Sensor 502 can detect Magnet 501, can't detect Magnet 501, judge with this when opening
Described upper cover 13 the most tightly covers.
Although present disclosure is as above, but the present invention is not limited to this.Any those skilled in the art, without departing from this
In the spirit and scope of invention, all can make various changes or modifications, therefore protection scope of the present invention should be with claim institute
Limit in the range of standard.
Claims (13)
1. a single step fully integrated bodily fluid sampling analyser, including:
Housing, the integrated of plural number adopt inspection portion, detection box, sensor, sealing film, upper cover, thief hatch, linear driving mechanism, control
Circuit processed and back stitching spring；
It is characterized in that,
Described integrated adopt inspection portion to adopt suction spindle, needle hub and test strips integrated by miniature；Described miniature suction spindle of adopting is fixed on needle hub, described
Test strips is embedded in needle hub lower surface, and described needle hub has that appearance is miniature adopts the through hole that suction spindle communicates with test strips, described integrated adopts
Inspection portion is a plurality of and arranged radially is in described detection box；
Described miniature suction spindle of adopting is hollow microneedles, is used for puncturing skin and adopting suction body fluid, adopts the body fluid being drawn onto by described needle hub
Through hole be delivered directly to described test strips；Described sensor is for reading produced by the reagent reacting in body fluid and test strips
Reaction information, gathers and detects a step and complete；
Described sealing film lays respectively at the upper and lower surface of described detection box, and described detection box arranges along its multiple radial direction and divides
Separate slot, described sealing film and described separation trough form the sealing reaction chamber of plural number；
Being covered on housing upper on described, described thief hatch is located on described and is covered, and described thief hatch is used for holding described miniature adopt
Suction spindle passes and draws back housing；
Described linear driving mechanism is positioned at below described detection box, is electrically connected at described control circuit, is used for driving described collection
Cheng Caijian portion moves so that miniature blood taking needle thrusts skin；
Described control circuit is used for controlling described linear driving mechanism and integrated adopts the motion of inspection portion, to control described miniature to adopt suction spindle
The degree of depth specified under skin is arrived during sampling；
Described back stitching spring is located in described each separation trough, is drawn back by described miniature blood taking needle after sampling.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Described linear driving mechanism includes push rod and push rod spring,
Described push rod is hollow, and described push rod has side opening near one end of detection box, for wearing out detection box following table at push rod
The inner chamber of push rod and described sealing reaction chamber is connected after face seal thin film；
Described push rod connects a negative pressure device away from one end of detection box；
Described push rod spring is for drawing back push rod integrated adopting after suction body fluid is adopted in inspection portion.
Single step the most according to claim 2 fully integrated bodily fluid sampling analyser, it is characterised in that
Also include stifled ring assemblies,
Described stifled ring assemblies includes stifled ring and stifled ring spring,
Described stifled ring annular is wrapped in described push rod outer surface, for described push rod for drive integrated adopt inspection portion motion and wear out
The breakage of thin film is sealed, to keep the sealing state of described sealing reaction chamber during detection box lower surface sealing film；
Described stifled ring spring compresses stifled ring at described stifled ring seal firmly breakage of thin film applied time and is close to thin film.
Single step the most according to claim 3 fully integrated bodily fluid sampling analyser, it is characterised in that
Described stifled ring is falope ring.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
The described miniature overall diameter adopting suction spindle is 50～500um.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Described sensor is optical pickocff, produces with the reagent reacting in test strips for reading the analyte in the body fluid taked
Raw readable optical signalling.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Also include that sensor circuit, described sensor circuit are used for sensing whether detected body part is positioned at appointment position.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Described detection box center is provided with annular wall, and described housing is provided with tumbler；
Described annular wall is provided with internal gear, and described tumbler is provided with external gear, and described tumbler can be by gear and described inspection
Survey box engages, to drive described detection box to rotate in the holding tank of housing.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
It is provided with the guide frame protruded out in described each separation trough, described needle hub has and described guide frame form fit
Hole, is used for keeping needle hub along described guide frame lengthwise movement in separation trough, limits the needle hub non-longitudinal position in separation trough
Move；
The end face of described each separation trough is additionally provided with through hole, is used for holding described miniature suction spindle of adopting and passes through.
Single step the most according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Described separation trough quantity is 2～50.
11. single step according to claim 10 fully integrated bodily fluid sampling analyser, it is characterised in that
Described separation trough quantity is 10.
12. single step according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Described upper interior surface is additionally provided with Magnet, is provided with Magnetic Sensor in described housing, when upper cover covers described Magnetic Sensor with
The connection of described magnet magnetic force the most tightly covers to detect described upper cover.
13. single step according to claim 1 fully integrated bodily fluid sampling analyser, it is characterised in that
Also include that display screen, described display location divide in casing upper half, be used for showing result data；
Described display screen side is provided with at least one button, is used for allowing user input control instruction.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018027930A1 (en) * | 2016-08-12 | 2018-02-15 | Medtrum Technologies Inc. | A one step all‐in‐one apparatus for body fluid sampling and sensing |
| CN107874767A (en) * | 2017-10-12 | 2018-04-06 | 杭州博拓生物科技股份有限公司 | The device of analyte in a kind of detection sample |
| CN109932404A (en) * | 2019-03-25 | 2019-06-25 | 上海交通大学医学院附属上海儿童医学中心 | A kind of online body fluid detection device and baby's oral secretion on-line measuring device |
| CN111134636A (en) * | 2018-11-05 | 2020-05-12 | 巧连科技股份有限公司 | Physiology detection module and wearable electronic device with same |
| CN113391071A (en) * | 2021-07-29 | 2021-09-14 | 宁波康和生物科技有限公司 | Blood sampling detection integrated glucometer based on self-adaptive blood volume detection technology |
| CN113391071B (en) * | 2021-07-29 | 2024-04-30 | 宁波康和生物科技有限公司 | Blood sampling detects integral type blood glucose meter based on self-adaptation blood volume detection technique |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000101A3 (en) * | 2000-06-27 | 2003-01-03 | Sarnoff Corp | Analyte monitor |
| WO2005084546A2 (en) * | 2004-03-06 | 2005-09-15 | Roche Diagnostics Gmbh | Body fluid sampling device |
| US20060085020A1 (en) * | 2002-04-19 | 2006-04-20 | Freeman Dominique M | Tissue penetration device |
| WO2008027319A2 (en) * | 2006-08-28 | 2008-03-06 | Intuity Medical, Inc. | Body fluid monitoring and sampling devices and methods |
| CN102056542A (en) * | 2008-06-07 | 2011-05-11 | 霍夫曼-拉罗奇有限公司 | Analysis system for detecting an analyte in a bodily fluid, cartridge for analytic device and method for creating a wound in a part of the body and examining the excreted body fluid |
| WO2011035867A3 (en) * | 2009-09-28 | 2011-05-19 | Roche Diagnostics Gmbh | Body fluid lancing, acquiring, and testing cartridge design |
| US20120197158A1 (en) * | 2009-02-18 | 2012-08-02 | Wolfgang Roedel | Handheld analysis device |
| US20130144189A1 (en) * | 2005-09-30 | 2013-06-06 | Intuity Medical, Inc. | Catalysts for body fluid sample extraction |
| CN103829953A (en) * | 2014-03-06 | 2014-06-04 | 无锡华平医疗科技有限公司 | One-step type integrated blood glucose meter |
| CN205072906U (en) * | 2015-10-27 | 2016-03-09 | 南阳市第二人民医院 | Tumour biopsy sampler |
-
2016
- 2016-08-12 CN CN201610665919.1A patent/CN106137223B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000101A3 (en) * | 2000-06-27 | 2003-01-03 | Sarnoff Corp | Analyte monitor |
| US20060085020A1 (en) * | 2002-04-19 | 2006-04-20 | Freeman Dominique M | Tissue penetration device |
| WO2005084546A2 (en) * | 2004-03-06 | 2005-09-15 | Roche Diagnostics Gmbh | Body fluid sampling device |
| US20130144189A1 (en) * | 2005-09-30 | 2013-06-06 | Intuity Medical, Inc. | Catalysts for body fluid sample extraction |
| WO2008027319A2 (en) * | 2006-08-28 | 2008-03-06 | Intuity Medical, Inc. | Body fluid monitoring and sampling devices and methods |
| CN102056542A (en) * | 2008-06-07 | 2011-05-11 | 霍夫曼-拉罗奇有限公司 | Analysis system for detecting an analyte in a bodily fluid, cartridge for analytic device and method for creating a wound in a part of the body and examining the excreted body fluid |
| US20120197158A1 (en) * | 2009-02-18 | 2012-08-02 | Wolfgang Roedel | Handheld analysis device |
| WO2011035867A3 (en) * | 2009-09-28 | 2011-05-19 | Roche Diagnostics Gmbh | Body fluid lancing, acquiring, and testing cartridge design |
| CN103829953A (en) * | 2014-03-06 | 2014-06-04 | 无锡华平医疗科技有限公司 | One-step type integrated blood glucose meter |
| CN205072906U (en) * | 2015-10-27 | 2016-03-09 | 南阳市第二人民医院 | Tumour biopsy sampler |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018027930A1 (en) * | 2016-08-12 | 2018-02-15 | Medtrum Technologies Inc. | A one step all‐in‐one apparatus for body fluid sampling and sensing |
| US11147486B2 (en) | 2016-08-12 | 2021-10-19 | Medtrum Technologies Inc. | One step all-in-one apparatus for body fluid sampling and sensing |
| CN107874767A (en) * | 2017-10-12 | 2018-04-06 | 杭州博拓生物科技股份有限公司 | The device of analyte in a kind of detection sample |
| CN107874767B (en) * | 2017-10-12 | 2020-11-24 | 杭州博拓生物科技股份有限公司 | Device for detecting analyzed substance in sample |
| CN111134636A (en) * | 2018-11-05 | 2020-05-12 | 巧连科技股份有限公司 | Physiology detection module and wearable electronic device with same |
| CN109932404A (en) * | 2019-03-25 | 2019-06-25 | 上海交通大学医学院附属上海儿童医学中心 | A kind of online body fluid detection device and baby's oral secretion on-line measuring device |
| CN113391071A (en) * | 2021-07-29 | 2021-09-14 | 宁波康和生物科技有限公司 | Blood sampling detection integrated glucometer based on self-adaptive blood volume detection technology |
| CN113391071B (en) * | 2021-07-29 | 2024-04-30 | 宁波康和生物科技有限公司 | Blood sampling detects integral type blood glucose meter based on self-adaptation blood volume detection technique |
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|---|---|
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