CN106136232A - A kind of preparation method of beneficial bacteria factor composite chewable tablet - Google Patents

A kind of preparation method of beneficial bacteria factor composite chewable tablet Download PDF

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Publication number
CN106136232A
CN106136232A CN201610499407.2A CN201610499407A CN106136232A CN 106136232 A CN106136232 A CN 106136232A CN 201610499407 A CN201610499407 A CN 201610499407A CN 106136232 A CN106136232 A CN 106136232A
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China
Prior art keywords
beneficial bacteria
parts
chewable tablet
bacteria factor
preparation
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CN201610499407.2A
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Chinese (zh)
Inventor
王香芬
罗春勤
史劲松
许正宏
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CHENGDU YONGAN YUANHE BIOTECHNOLOGY Co Ltd
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CHENGDU YONGAN YUANHE BIOTECHNOLOGY Co Ltd
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Priority to CN201610499407.2A priority Critical patent/CN106136232A/en
Publication of CN106136232A publication Critical patent/CN106136232A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Medicinal Preparation (AREA)

Abstract

The present invention relates to the preparation method of a kind of beneficial bacteria factor composite chewable tablet, comprise the following steps: S1, prepare beneficial bacteria factor complex: in hemicellulase liquid, be directly added into Rhizoma amorphophalli powder in a reservoir, addition is the 1/10~1/8 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially pass through filtration, be concentrated in vacuo, the technique that is spray-dried prepares beneficial bacteria factor complex;S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 100~120 parts, binding agent 30~45 parts, sucrose: 12~16 parts, oatmeal: 20~30 parts, citric acid: 1~5 part, stearic acid: 2~4 parts;S3, mix and blend;S4, make soft material;S5, tabletting;S6, low-temperature bake;S7, packaging.It is an advantage of the current invention that: intestinal microecology system can play the effect of optimization, may act as immuno-stimulator, improve medicine or antigen immune response ability, after adding fruit juice, taste enriches, and has preferable mouthfeel after Herba bromi japonici compatibility.

Description

A kind of preparation method of beneficial bacteria factor composite chewable tablet
Technical field
The present invention relates to the preparation method of chewable tablet, the preparation method of a kind of beneficial bacteria factor composite chewable tablet.
Background technology
Chewable tablet refers to chew or suck the tablet that clothes make sheet swallow after dissolving in oral cavity, is commonly incorporated into sucrose, Oleum menthae etc. Sweeting agent and flavorant adjust taste, and through chewing, rear surface is long-pending to increase tablet, can promote medicine dissolving in vivo and absorption. Taking convenience, can swallow, chew containing sucking or taking after water-dispersible.Through chewing, rear surface is long-pending to increase tablet, can promote that medicine exists Even if internal dissolving and absorption it is also ensured that take medicine on time, are especially suitable for old man, child, apoplexy trouble under exsiccosis Person, swallow difficulty and gastrointestinal function difference patient, it is possible to reduce medicine to gastrointestinal bear.Therefore chewable tablet is disappeared by vast The welcome of the person of expense.
But, nowadays rhythm of life is accelerated, and can not take out time motion, how could realize effective absorption of nutrition? Threpsology expert thinks: only puts into by nutrition and can not solve problem, for the practical situation of contemporary people, improves the suction of intestinal Receipts ability is a good method, and beneficial bacteria factor is to promote the factor of probiotics propagation in human body, and it is to health, Nai Zhiying The absorption supported is most important.
Summary of the invention
It is an object of the invention to overcome the shortcoming of prior art, it is provided that the preparation side of a kind of beneficial bacteria factor composite chewable tablet Method, can play the effect of optimization to intestinal microecology system, may act as immuno-stimulator, improves medicine or antigen immune should Answering ability, after adding fruit juice, taste enriches, and has preferable mouthfeel after Herba bromi japonici compatibility.
The purpose of the present invention is achieved through the following technical solutions: the preparation method of a kind of beneficial bacteria factor composite chewable tablet, Comprise the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/10~1/8 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially pass through filtration, The technique be concentrated in vacuo, being spray-dried prepares beneficial bacteria factor complex;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 100~120 parts, binding agent 30~45 parts, sugarcane Sugar: 12~16 parts, oatmeal: 20~30 parts, citric acid: 1~5 part, stearic acid: 2~4 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, stir, Every 40g mixed material adds fruit juice 2~6ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 20~25 DEG C, relatively Humidity is 40~50%, and to control tablet machine pressure be 250~300kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, at 40~50 DEG C toast 40~ 50min, takes out when the moisture to sheet-like particle is 1~3%, obtains chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed.
In step S1, comprising the concrete steps that of described filtration: the liquid obtained through enzymolysis is crossed 200~400 mesh sieves.
In step S1, described be concentrated in vacuo comprise the concrete steps that: vacuum concentration equipment will be loaded through the liquid filtered In, controlling vacuum is 60~90kPa, and heating evaporation concentrates, and to control temperature be 45~60 DEG C, obtains paste.
In step S1, comprising the concrete steps that of described spray drying: will put in baking oven through the paste being concentrated in vacuo, Controlling temperature is 60~70 DEG C, toasts 20~30min, simultaneously in baking process, at interval of 3~5 minutes to paste surface Carry out spraying treatment.
In step S4, described fruit juice is in Sucus Mali pumilae, Fructus Citri tangerinae juice, bananas juice, Lychee juice, Fructus psidii guajavae immaturus juice, pear juice Kind.
The invention have the advantages that
1, the beneficial bacteria factor complex of the present invention carries out enzymolysis by hemicellulase liquid to Rhizoma amorphophalli powder, and passes through series of physical Effect obtains, and not by the digested absorption of human body intestines and stomach, is directly entered large intestine, and highly selective gives bacillus bifidus etc. in intestinal Probiotics provides culture matrix, stimulates rapidly probiotics amount reproduction, improves probiotics vigor, improve intestine microenvironment, Improve every physiological function comprehensively, be preferentially combined with the receptor of human body intestinal canal cell surface, prevent pathogenic microorganism to animal body The adhesion of intestinal mucosal epithelial, it is achieved the eliminating of pathogenetic bacteria.
2, after taking the chewable tablet of beneficial bacteria factor complex, intestinal peristalsis promoting can be stimulated, improve function of intestinal canal, increase feces wet Spend and keep certain osmotic pressure, thus prevent the generation of constipation.
3, Oligomeric manna sugar has an immunogenicity, effective stimulus immunne response, and can be with toxin, virus and fungal cell Surface combine, strengthen cell and humoral immune reaction, fungi-proofing disease-resistant.
4, the chewable tablet of the present invention is also added into Herba bromi japonici and fruit juice, can be different according to the fruit juice kind added, and obtains difference The chewable tablet of taste, rich in taste, with oatmeal compatibility, further improves the mouthfeel of chewable tablet, by consumers in general's Welcome.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, but protection scope of the present invention is not limited to following institute State.
[embodiment 1]:
The preparation method of a kind of beneficial bacteria factor composite chewable tablet, comprises the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/8 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially passes through filtration, vacuum dense Contracting, the technique being spray-dried prepare beneficial bacteria factor complex, the liquid obtained through enzymolysis is crossed 400 mesh sieves, will pass through The liquid filtered loads in vacuum concentration equipment, and controls vacuum is 60kPa, heating evaporation concentration, and to control temperature be 60 DEG C, Obtaining paste, will put in baking oven through the paste being concentrated in vacuo, controlling temperature is 60 DEG C, toasts 30min, is drying simultaneously During Kao, at interval of 5 minutes, paste surface is carried out spraying treatment;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 120 parts, binding agent 30 parts, sucrose: 16 parts, swallow Flour: 30 parts, citric acid: 1 part, stearic acid: 4 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, described fruit Juice is Sucus Mali pumilae, stirs, and every 40g mixed material adds fruit juice 6ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 25 DEG C, relative humidity It is 50%, and to control tablet machine pressure be 250kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, toasts 40min, extremely at 50 DEG C Take out when the moisture of sheet-like particle is 3%, obtain chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed.
[embodiment 2]:
The preparation method of a kind of beneficial bacteria factor composite chewable tablet, comprises the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/9 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially passes through filtration, vacuum dense Contracting, the technique being spray-dried prepare beneficial bacteria factor complex, the liquid obtained through enzymolysis is crossed 300 mesh sieves, will pass through The liquid filtered loads in vacuum concentration equipment, and controls vacuum is 70kPa, heating evaporation concentration, and to control temperature be 50 DEG C, Obtaining paste, will put in baking oven through the paste being concentrated in vacuo, controlling temperature is 65 DEG C, toasts 25min, is drying simultaneously During Kao, at interval of 4 minutes, paste surface is carried out spraying treatment;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 110 parts, binding agent 40 parts, sucrose: 14 parts, swallow Flour: 25 parts, citric acid: 3 parts, stearic acid: 3 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, described fruit Juice is Fructus Citri tangerinae juice, stirs, and every 40g mixed material adds fruit juice 4ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 22 DEG C, relative humidity It is 45%, and to control tablet machine pressure be 280kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, toasts 45min, extremely at 45 DEG C Take out when the moisture of sheet-like particle is 2%, obtain chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed
[embodiment 3]:
The preparation method of a kind of beneficial bacteria factor composite chewable tablet, comprises the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/10 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially passes through filtration, vacuum The technique concentrate, being spray-dried prepares beneficial bacteria factor complex, and the liquid obtained through enzymolysis is crossed 280 mesh sieves, will be through The liquid filtered loads in vacuum concentration equipment, and controls vacuum is 80kPa, heating evaporation concentration, and to control temperature be 52 DEG C, obtain paste, will put in baking oven through the paste being concentrated in vacuo, controlling temperature is 66 DEG C, toasts 24min, simultaneously In baking process, at interval of 4 minutes, paste surface is carried out spraying treatment;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 112 parts, binding agent 35 parts, sucrose: 15 parts, swallow Flour: 23 parts, citric acid: 4 parts, stearic acid: 2 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, described fruit Juice is bananas juice or Lychee juice, stirs, and every 40g mixed material adds fruit juice 5ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 23 DEG C, relative humidity It is 46%, and to control tablet machine pressure be 280kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, toasts 45min, extremely at 45 DEG C Take out when the moisture of sheet-like particle is 2%, obtain chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed.
[embodiment 4]:
The preparation method of a kind of beneficial bacteria factor composite chewable tablet, comprises the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/10 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially passes through filtration, vacuum The technique concentrate, being spray-dried prepares beneficial bacteria factor complex, and the liquid obtained through enzymolysis is crossed 200 mesh sieves, will be through The liquid filtered loads in vacuum concentration equipment, and controls vacuum is 90kPa, heating evaporation concentration, and to control temperature be 45 DEG C, obtain paste, will put in baking oven through the paste being concentrated in vacuo, controlling temperature is 70 DEG C, toasts 20min, simultaneously In baking process, at interval of 3~5 minutes, paste surface is carried out spraying treatment;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 100 parts, binding agent 45 parts, sucrose: 12 parts, swallow Flour: 20 parts, citric acid: 5 parts, stearic acid: 2 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, described fruit Juice is Fructus psidii guajavae immaturus juice or pear juice, stirs, and every 40g mixed material adds fruit juice 2ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 20 DEG C, relative humidity It is 40%, and to control tablet machine pressure be 300kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, toasts 50min, extremely at 40 DEG C Take out when the moisture of sheet-like particle is 1%, obtain chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed.

Claims (5)

1. the preparation method of a beneficial bacteria factor composite chewable tablet, it is characterised in that: comprise the following steps:
S1, prepare beneficial bacteria factor complex: contain a certain amount of hemicellulase liquid in a reservoir, then in hemicellulase liquid Being directly added into Rhizoma amorphophalli powder, addition is the 1/10~1/8 of the volume of hemicellulase liquid, after being sufficiently stirred for, sequentially pass through filtration, The technique be concentrated in vacuo, being spray-dried prepares beneficial bacteria factor complex;
S2, dispensing: carry out dispensing by following weight portion: beneficial bacteria factor complex: 100~120 parts, binding agent 30~45 parts, sugarcane Sugar: 12~16 parts, oatmeal: 20~30 parts, citric acid: 1~5 part, stearic acid: 2~4 parts;
S3, mix and blend: after being sufficiently stirred for by the material of above-mentioned weight portion, cross 100 mesh sieves, remove oarse-grained material;
S4, make soft material: stirring the mixed material after filtering are put into container, then in container, adds fruit juice, stir, Every 40g mixed material adds fruit juice 2~6ml, obtains soft material;
S5, tabletting: carrying out tabletting in the soft material obtained in step S4 is added tablet machine, indoor temperature is 20~25 DEG C, relatively Humidity is 40~50%, and to control tablet machine pressure be 250~300kg/cm2, obtain sheet-like particle;
S6, low-temperature bake: spread out by the sheet-like particle obtained in step S5, be placed in baking oven, at 40~50 DEG C toast 40~ 50min, takes out when the moisture to sheet-like particle is 1~3%, obtains chewable tablet granule;
S7, packaging: chewable tablet granule employing food stage aluminum foil package material is packed.
The preparation method of a kind of beneficial bacteria factor composite chewable tablet the most according to claim 1, it is characterised in that: step S1 In, comprising the concrete steps that of described filtration: the liquid obtained through enzymolysis is crossed 200~400 mesh sieves.
The preparation method of a kind of beneficial bacteria factor composite chewable tablet the most according to claim 2, it is characterised in that: step S1 In, described be concentrated in vacuo comprise the concrete steps that: will load in vacuum concentration equipment through the liquid filtered, controlling vacuum is 60~90kPa, heating evaporation concentrates, and to control temperature be 45~60 DEG C, obtains paste.
The preparation method of a kind of beneficial bacteria factor composite chewable tablet the most according to claim 3, it is characterised in that: step S1 In, comprising the concrete steps that of described spray drying: will put in baking oven through the paste that is concentrated in vacuo, control temperature be 60~ 70 DEG C, toast 20~30min, simultaneously in baking process, at interval of 3~5 minutes, paste surface is carried out spraying treatment.
The preparation method of a kind of beneficial bacteria factor composite chewable tablet the most according to claim 1, it is characterised in that: step S4 In, described fruit juice is the one in Sucus Mali pumilae, Fructus Citri tangerinae juice, bananas juice, Lychee juice, Fructus psidii guajavae immaturus juice, pear juice.
CN201610499407.2A 2016-06-30 2016-06-30 A kind of preparation method of beneficial bacteria factor composite chewable tablet Pending CN106136232A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109832334A (en) * 2017-11-28 2019-06-04 东阿阿胶股份有限公司 A kind of donkey milk piece of strengthen immunity and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1904059A (en) * 2006-05-29 2007-01-31 湖北广华生物有限公司 Production method of konjak mannose using cellulase
CN101816386A (en) * 2010-04-07 2010-09-01 云南富源金田原农产品开发有限责任公司 Konjak oligosaccharide buccal tablets
CN105614897A (en) * 2016-01-29 2016-06-01 福建农林大学 Konjac glucomannan, strawberry and vitamin C chewable tablet and method for preparing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1904059A (en) * 2006-05-29 2007-01-31 湖北广华生物有限公司 Production method of konjak mannose using cellulase
CN101816386A (en) * 2010-04-07 2010-09-01 云南富源金田原农产品开发有限责任公司 Konjak oligosaccharide buccal tablets
CN105614897A (en) * 2016-01-29 2016-06-01 福建农林大学 Konjac glucomannan, strawberry and vitamin C chewable tablet and method for preparing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109832334A (en) * 2017-11-28 2019-06-04 东阿阿胶股份有限公司 A kind of donkey milk piece of strengthen immunity and preparation method thereof

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Application publication date: 20161123