CN106135691A - A kind of have the feed additive promoting that intestine of young pigs is healthy - Google Patents
A kind of have the feed additive promoting that intestine of young pigs is healthy Download PDFInfo
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- CN106135691A CN106135691A CN201610492082.5A CN201610492082A CN106135691A CN 106135691 A CN106135691 A CN 106135691A CN 201610492082 A CN201610492082 A CN 201610492082A CN 106135691 A CN106135691 A CN 106135691A
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Abstract
The invention reside in and a kind of feed additive having and promoting that intestine of young pigs is healthy is provided, belong to feed additive field.Additive of the present invention is made up of by weight following raw material: culture propagation culture 10 15 parts, Semen Coicis 8 12 parts, composite vegetables extractive 10 15 parts, Rhizoma Alpiniae Officinarum 68 parts, Fructus Citri Sarcodactylis 12 16 parts.This additive application can promote that intestine of young pigs fine hair is grown in piglet, increases probiotics Microflora in intestinal, improves Intestinal Mucosal Immunity function, improves the growth performance of piglet, reduces diarrhea rate, significantly improves culture benefit.The most also there is the effect of substitute antibiotics, for promoting that pig-breeding industry develops significant towards green safety direction.
Description
Technical field
The invention belongs to feed additive field, particularly relate to a kind of feedstuff interpolation having and promoting intestine of young pigs healthy
Agent.
Background technology
Intestine of young pigs health problem, not only results in piglet diarrhea, also can affect digesting and assimilating of feedstuff Middle nutrition material,
The final growth performance affecting pig.Research shows, present the following aspects of intestine of young pigs health watch: 1. intestinal structural development is good
Good, intestinal villus is complete；2. in intestinal, beneficial microbe colony quantity has comparative advantage；3. Intestinal Mucosal Immunity perfect in shape and function.Can
To say, intestinal health directly influences piglet culture benefit.And along with current pig cultivation concentration degree more and more higher, cultivation hardware and
Software environment is caught up with the most completely, causes intestine of young pigs hypoplasia, affects pig farm culture benefit, according to statistics, every year because of piglet
The direct economic loss that bowel problems causes is up to 12,000,000,000 yuan.
At present have become as conventional means by using antibiosis usually to prevent and treat piglet diarrhea, but life-time service antibiotic
Drug residue problem can be caused, be detrimental to health, meanwhile, also can produce superbacteria, destroy ecological balance.How to develop
The green additive of effective substitute antibiotics can have become as the urgent needs that animal husbandry develops towards green safety direction.
Therefore, develop a kind of green feed additive that can effectively facilitate intestine of young pigs health, for improving cultivation effect
Benefit, protection environment has great importance.
Summary of the invention
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: by following raw material group by weight
Become: culture propagation culture 10-15 part, Semen Coicis 8-12 part, composite vegetables extractive 10-15 part, Rhizoma Alpiniae Officinarum 6-8 part, Fructus Citri Sarcodactylis
12-16 part.
The preparation method of described culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 40-60 mesh sieve, obtain yeast
Mixture；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 2-3:1:1-2:2-4:2-3, powder
Broken, cross 80 mesh sieves, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add 30-35% weight at the bottom of yeast mixt and culture propagation
Sterilized water, after stirring, controls temperature 30-35 DEG C, carries out sealing and fermenting 36-48h, crosses 40-60 mesh sieve after drying and crushing,
Culture propagation culture；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:45-55；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 4-8:2-3:5-7, pulverizes, cross 60 mesh sieves, must pulverize mixed
Compound, adds the distilled water of 10-15 times in crushed mixture, keeps temperature 95-100 DEG C, extract 2-3h, cool the temperature to
35-45 DEG C, add crushed mixture 0.1-0.3% weight compound enzyme, enzymolysis 1-2h, after be warming up to 85 DEG C maintain 20-30min,
Filtering to get filtrate, filter vacuum is dried, obtains composite vegetables extractive；
Described compound enzyme is made up of by weight 3-5:1-2:2-4 neutral protease, pectase, cellulase.
The feed additive of the present invention addition in swine rations is 800-1200g/ ton.
Beneficial effect:
In culture propagation culture preparation process of the present invention, Candida utilis powder, beer yeast powder, mortierella Diding powder are effectively inhaled
Receive the active component of green tea and Herba Cichorii.In R&D process, inventors be surprised to learn that the green tea in fermentation substrate becomes with Herba Cichorii
Divide and can be effectively improved oligosaccharide content in culture propagation culture material, be the important achievement of the present invention.
The present invention is simple to the extracting method of composite vegetables extractive, is greatly saved extraction time and cost, and
Ensure that the extraction ratio of effective ingredient in Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae.
The present invention by science compound, by merged green tea and Herba Cichorii active component culture propagation culture and multiple in
Herb ingredients achieves organic assembling, can effectively substitute antibiotics application in pig starter feed, promote intestine of young pigs fine hair
Grow, increase probiotics Microflora in intestinal, improve Intestinal Mucosal Immunity function, improve the growth performance of piglet, reduce abdomen
Rush down rate, significantly improve culture benefit.
Specific embodiment:
Embodiment 1:
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material: ferment
Female fermentation culture medium 13 parts, Semen Coicis 10 parts, composite vegetables extractive 13 parts, Rhizoma Alpiniae Officinarum 7 parts, Fructus Citri Sarcodactylis 14 parts.
The preparation method of described culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 50 mesh sieves, obtain yeast and mix
Compound；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 2.5:1:1.5:3:2.5, powder
Broken, cross 80 mesh sieves, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add the aseptic of 32% weight at the bottom of yeast mixt and culture propagation
Water, after stirring, controls temperature 33 DEG C, carries out sealing and fermenting 42h, crosses 50 mesh sieves after drying and crushing, obtains culture propagation and cultivates
Thing；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:50；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 6:2.5:6, pulverize, cross 60 mesh sieves, obtain crushed mixture,
In crushed mixture, add the distilled water of 13 times, keep temperature 98 DEG C, extract 2.5h, cool the temperature to 40 DEG C, add and pulverize
The compound enzyme of mixture 0.2% weight, enzymolysis 1.5h, after be warming up to 85 DEG C maintain 25min, filter to get filtrate, filter vacuum is dried
After, obtain composite vegetables extractive；
Described compound enzyme is made up of by weight 4:1.5:3 neutral protease, pectase, cellulase.
The feed additive of the present invention addition in swine rations is 1000g/ ton.
Embodiment 2:
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material: ferment
Female fermentation culture medium 10 parts, Semen Coicis 8 parts, composite vegetables extractive 10 parts, Rhizoma Alpiniae Officinarum 6 parts, Fructus Citri Sarcodactylis 12 parts.
The preparation method of described culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 40 mesh sieves, obtain yeast and mix
Compound；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 2:1:1:2:2, pulverize, cross 80
Mesh sieve, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add the aseptic of 30% weight at the bottom of yeast mixt and culture propagation
Water, after stirring, controls temperature 30 DEG C, carries out sealing and fermenting 36h, crosses 40 mesh sieves after drying and crushing, obtains culture propagation and cultivates
Thing；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:45；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 4:2:5, pulverizes, cross 60 mesh sieves, obtain crushed mixture, to
Adding the distilled water of 10 times in crushed mixture, keep temperature 95 DEG C, extract 2h, cool the temperature to 35 DEG C, addition is pulverized and mixed
The compound enzyme of thing 0.1% weight, enzymolysis 1h, after be warming up to 85 DEG C and maintain 20min, filter to get filtrate, filter vacuum is dried,
Composite vegetables extractive；
Described compound enzyme is made up of by weight 3:1:2 neutral protease, pectase, cellulase.
The feed additive of the present invention addition in swine rations is 1200g/ ton.
Embodiment 3:
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material: ferment
Female fermentation culture medium 15 parts, Semen Coicis 12 parts, composite vegetables extractive 15 parts, Rhizoma Alpiniae Officinarum 8 parts, Fructus Citri Sarcodactylis 16 parts.
The preparation method of described culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 60 mesh sieves, obtain yeast and mix
Compound；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 3:1:2:4:3, pulverize, mistake
80 mesh sieves, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add the aseptic of 35% weight at the bottom of yeast mixt and culture propagation
Water, after stirring, controls temperature 35 DEG C, carries out sealing and fermenting 48h, drying and crushing consequence 60 mesh sieve, obtains culture propagation and cultivates
Thing；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:55；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 8:3:7, pulverize, cross 60 mesh sieves, obtain crushed mixture,
In crushed mixture, add the distilled water of 15 times, keep temperature 100 DEG C, extract 3h, cool the temperature to 45 DEG C, add pulverizing mixed
The compound enzyme of compound 0.3% weight, enzymolysis 2h, after be warming up to 85 DEG C and maintain 30min, filter to get filtrate, filter vacuum is dried,
Obtain composite vegetables extractive；
Described compound enzyme is made up of by weight 5:2:4 neutral protease, pectase, cellulase.
The feed additive of the present invention addition in swine rations is 800g/ ton.
Embodiment 4:
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material: ferment
Female fermentation culture medium 8 parts, Semen Coicis 14 parts, composite vegetables extractive 16 parts, Rhizoma Alpiniae Officinarum 4 parts, Fructus Citri Sarcodactylis 18 parts.
Remaining is with embodiment 1.
Embodiment 5:
A kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material: ferment
Female fermentation culture medium 13 parts, Semen Coicis 10 parts, composite vegetables extractive 13 parts, Rhizoma Alpiniae Officinarum 7 parts, Fructus Citri Sarcodactylis 14 parts.
The preparation method of described culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 30 mesh sieves, obtain yeast and mix
Compound；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 4:1:3:1:5, pulverize, cross 80
Mesh sieve, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add the aseptic of 40% weight at the bottom of yeast mixt and culture propagation
Water, after stirring, controls temperature 38 DEG C, carries out sealing and fermenting 34h, drying and crushing consequence 80 mesh sieve, obtains culture propagation and cultivates
Thing；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:60；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 2:4:9, pulverizes, cross 60 mesh sieves, obtain crushed mixture, to
Adding the distilled water of 8 times in crushed mixture, keep temperature 90 DEG C, extract 1.5h, cool the temperature to 50 DEG C, addition is pulverized and mixed
The compound enzyme of thing 0.08% weight, enzymolysis 3h, after be warming up to 85 DEG C and maintain 35min, filter to get filtrate, filter vacuum is dried,
Composite vegetables extractive；
Described compound enzyme is made up of by weight 2:3:1 neutral protease, pectase, cellulase.
The feed additive of the present invention addition in swine rations is 1000g/ ton.
Test example:
Select the miscellaneous piglet of health " DLY " ternary 240 of about 7.2kg, be divided into 6 process groups, a matched group and 5
Embodiment group, each process 4 repetition, 10 pigs of each repetition.Matched group piglet feeds conventional daily ration, 5 embodiment components
Not adding, in conventional daily ration, the additive that embodiment 1-5 prepares, piglet searches for food and drinks water, and carries out immunity and anthelmintic routinely,
Experimental period is 30 days.The production performance of different disposal group piglet, intestinal (jejunum) mucosa-immune index, intestinal (jejunum) fine hair are high
Degree/Crypt depth result is as shown in table 1-4.
The production performance of table 1 piglet
| Project | Matched group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Daily ingestion amount (g/d) | 345.1 | 404.8 | 395.0 | 396.2 | 346.3 | 341.9 |
| Daily gain (g/d) | 251.2 | 341.8 | 331.2 | 333.5 | 254.8 | 259 |
| Feed-weight ratio | 1.37 | 1.18 | 1.19 | 1.19 | 1.36 | 1.32 |
| Diarrhea rate (%) | 13.5 | 3.4 | 3.6 | 3.7 | 11.2 | 12.8 |
Table 2 Jejunal mucosa immune indexes
| Project | Matched group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| IL-2(ng/ml) | 2.12 | 2.98 | 2.88 | 2.86 | 2.21 | 2.18 |
| IL-6(ng/ml) | 0.14 | 0.46 | 0.43 | 0.42 | 0.16 | 0.17 |
Table 3 intestinal height of naps/Crypt depth index
| Project | Matched group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Height of naps/Crypt depth | 2.68 | 3.93 | 2.86 | 2.88 | 2.72 | 2.71 |
From table 1, compared with matched group, each technical parameter of embodiment 1-3(is all in the range of the present invention program) piglet day
Feed intake, daily gain significantly improve, and feed-weight ratio, diarrhea rate are all remarkably decreased.Parameters not or not exclusively in skill of the present invention
Embodiment 4-5 in art scheme is compared with matched group, and the equal difference of the daily ingestion amount of piglet, daily gain, feed-weight ratio, diarrhea rate is not
Greatly.
From table 2, compared with matched group, each technical parameter of embodiment 1-3(is all in the range of the present invention program) young
In pig jejunum, interleukin II (IL-2) and interleukin-6 (IL-6) content significantly improve.Parameters not or the completeest
Entirely in embodiment 4-5 in technical solution of the present invention compared with matched group, in Jejunum of Piglets, the equal difference of IL-2 and IL-6 is little.
Intestine of young pigs Villus atrophy, it is meant that mature cell reduces, absorption function declines；Crypt depth reflects cell
Production rate, crypts shoals, and shows that cell maturation rate rises, and secretory function strengthens.Height of naps is comprehensive with the ratio of Crypt depth
Reflecting the functional status of small intestinal, ratio declines, and shows that mucosa is impaired, and digestive and absorptive functions declines, and is often accompanied by diarrhoea and occurs.From
Table 3 is visible, and each technical parameter of embodiment 1-3(is all in the range of the present invention program) height of naps/crypts of Jejunum of Piglets is deep
Degree ratio is significantly higher than matched group, parameters not or not exclusively embodiment 4-5 in technical solution of the present invention with compare
Group is compared, and the height of naps of Jejunum of Piglets/Crypt depth ratio difference is little.
Claims (6)
1. one kind has the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: it is made up of by weight following raw material:
Culture propagation culture 10-15 part, Semen Coicis 8-12 part, composite vegetables extractive 10-15 part, Rhizoma Alpiniae Officinarum 6-8 part, Fructus Citri Sarcodactylis 12-
16 parts.
The most according to claim 1 a kind of have the feed additive promoting that intestine of young pigs is healthy, it is characterised in that: by with
Lower raw material forms by weight: culture propagation culture 13 parts, Semen Coicis 10 parts, composite vegetables extractive 13 parts, Rhizoma Alpiniae Officinarum 7
Part, Fructus Citri Sarcodactylis 14 parts.
A kind of feed additive with promotion intestine of young pigs health the most according to claim 1, it is characterised in that: described
The preparation method of culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 40-60 mesh sieve, obtain yeast
Mixture；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 2-3:1:1-2:2-4:2-3, powder
Broken, cross 80 mesh sieves, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add 30-35% weight at the bottom of yeast mixt and culture propagation
Sterilized water, after stirring, controls temperature 30-35 DEG C, carries out sealing and fermenting 36-48h, drying and crushing consequence 40-60 mesh sieve, obtains
Culture propagation culture；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:45-55；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 4-8:2-3:5-7, pulverizes, cross 60 mesh sieves, must pulverize mixed
Compound, adds the distilled water of 10-15 times in crushed mixture, keeps temperature 95-100 DEG C, extract 2-3h, cool the temperature to
35-45 DEG C, add crushed mixture 0.1-0.3% weight compound enzyme, enzymolysis 1-2h, after be warming up to 85 DEG C maintain 20-30min,
Filtering to get filtrate, filter vacuum is dried, obtains composite vegetables extractive；
Described compound enzyme is made up of by weight 3-5:1-2:2-4 neutral protease, pectase, cellulase.
A kind of feed additive with promotion intestine of young pigs health the most according to claim 1, it is characterised in that: described
The preparation method of culture propagation culture:
(1) by Candida utilis powder, beer yeast powder, mortierella Diding powder mix homogeneously, pulverize, cross 50 mesh sieves, obtain yeast and mix
Compound；
(2) green tea powder, Herba Cichorii powder, Rhizoma Atractylodis Macrocephalae powder, Testa Tritici, bean cake are mixed according to weight ratio 2.5:1:1.5:3:2.5, powder
Broken, cross 80 mesh sieves, and carry out high-temp steam sterilizing, obtain yeast fermentable substrate；
(3) yeast mixt and yeast fermentable substrate are mixed, add the aseptic of 32% weight at the bottom of yeast mixt and culture propagation
Water, after stirring, controls temperature 33 DEG C, carries out sealing and fermenting 42h, drying and crushing consequence 50 mesh sieve, obtains culture propagation and cultivates
Thing；
Described yeast mixt and yeast fermentable substrate mix according to weight ratio 1:50；
The preparation method of described composite vegetables extractive:
Herba Houttuyniae, Radix Rhodiolae, Fructus Hippophae are mixed according to weight ratio 6:2.5:6, pulverize, cross 60 mesh sieves, obtain crushed mixture,
In crushed mixture, add the distilled water of 13 times, keep temperature 98 DEG C, extract 2.5h, cool the temperature to 40 DEG C, add and pulverize
The compound enzyme of mixture 0.2% weight, enzymolysis 1.5h, after be warming up to 85 DEG C maintain 25min, filter to get filtrate, filter vacuum is dried
After, obtain composite vegetables extractive；
Described compound enzyme is made up of by weight 4:1.5:3 neutral protease, pectase, cellulase.
5. promote the feed additive of intestine of young pigs health according to having described in claim 1-4 any one, its feature exists
In: the feed additive of the present invention addition in swine rations is 800-1200g/ ton.
A kind of feed additive with promotion intestine of young pigs health the most according to claim 5, it is characterised in that: this
Bright feed additive addition in swine rations is 1000g/ ton.
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| CN107927405A (en) * | 2018-01-05 | 2018-04-20 | 浙江新篁生物技术有限公司 | A kind of son's pig feed additive and its manufacture method |
| CN110338287A (en) * | 2019-07-15 | 2019-10-18 | 江西省科学院生物资源研究所 | A kind of probiotics plant extracts compound additive that can improve sow fertility rate |
| CN115024411A (en) * | 2022-06-13 | 2022-09-09 | 浙江大学 | Feed additive for reducing diarrhea rate of piglets |
| EP4205754A1 (en) * | 2021-12-30 | 2023-07-05 | Léon Cariel | Antiviral plant extract composition and method for preparing such composition |
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| CN115024411A (en) * | 2022-06-13 | 2022-09-09 | 浙江大学 | Feed additive for reducing diarrhea rate of piglets |
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