CN106124241B - The sampling device of solid hard capsule - Google Patents
The sampling device of solid hard capsule Download PDFInfo
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- CN106124241B CN106124241B CN201610654663.4A CN201610654663A CN106124241B CN 106124241 B CN106124241 B CN 106124241B CN 201610654663 A CN201610654663 A CN 201610654663A CN 106124241 B CN106124241 B CN 106124241B
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- sampling
- mandril
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- capsule
- rack
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention belongs to pharmacy ancillary equipment fields, more particularly to a kind of sampling device of solid hard capsule, its upper rack installs horizontal translation device, the top of horizontal translation device front mounting plate is installed by lifting gear, lower part is installed by transfer block, lifting gear drives discharge mandril to move up and down, through-hole is set in transfer block, the sampling box of central rack is equipped with mutually independent cavity, frame lower installation push-in mandril, through-hole, mandril is discharged, the quantity and arrangement of cavity and push-in mandril are identical as the die hole of capsule filler cope plate, through-hole is identical as the aperture of die hole.Automatic sampling can be realized through the invention, while can realize the real-time online sampling of capsule, without manually, reducing the labor intensity of operator, subsampling operation is more convenient；It weighs respectively to the capsule in sampling box in each cavity, targetedly can find the problem and be adjusted, save the repair time, improve maintenance efficiency, can resume production faster.
Description
Technical field
The present invention relates to a kind of sampling devices of solid hard capsule, belong to pharmacy ancillary equipment field.
Background technology
Capsule refers to being filled in drug in hollow hard capsules or elastomeric flexible capsule and manufactured solid pharmaceutical preparation.
In the production process of capsule, need to inspect the loading amount of capsule by random samples at any time, to ensure the qualification rate of produced capsule.
Traditional methods of sampling of capsule is as follows at present, and container containing is periodically placed on the outlet of capsule filler by operator
Place by hand picks out continuous several groups of capsules obtained, and this sampling operation is relatively complicated, to capsule cannot in real time exist
Line is sampled, and can increase the labor intensity of operator.
Except above-mentioned points, it in sampling Detection process, needs that first these capsules picked out are placed on weighing device and claims
Amount is finally compared with the standard weights of capsule, then by the way that the weight of averagely single capsule is calculated if inspection again
The weight measured has difference with standard weights, then showing the amounts of the solid drugs filled in capsule, there are problems.
But solid drugs be typically from the capsule that the sampled needle of powder disk enters its corresponding template (quantity of sampling probe with
The quantity of die hole is consistent with position in template --- die hole, that is, capsule putting hole, each sampling probe be in powder disk powder fall into it is each right
Answer the channel in capsule), thus the reason for causing capsule weight larger with its standard weights difference have it is following two：
One, there are problems for the solid drugs uniformity in powder disk；
Two, there are problems that blanking is not smooth or sampling probe is blocked by solid drugs in sampling probe.
After there is the above problem, the technological means of generally use is that the uniformity of solid drugs in powder disk is made to improve at present,
If the uniformity of solid drugs still remains problem above after improving, it is shown to be above-mentioned second of reason.
But due to current traditional sampling Detection method be picked out in the exit of capsule filler it is continuous obtained multigroup
Capsule, which is collected, weighs, therefore the average single capsule quality measured is the average value of all sampled capsules agent, is passed through
This mode can not targetedly find out be which either which sampling probe occurs that blanking is not smooth or sampling probe quilt
The problem of solid drugs block, the personnel that just need repairing at this time overhaul all sampling probes, thus it is possible, on the one hand, increasing
The workload of maintenance personal, causes that labor intensity is big, ineffective problem, and on the other hand, the repair time is long, be bound to
Capsule preparation work can be delayed, to influence normal production.
Currently, there are no good modes to solve the above problems.
Invention content
The technical problem to be solved by the present invention is to：Overcome deficiency in the prior art, automatic pumping can be realized by providing one kind
Sample and the sampling device that real-time online sampling and the convenient solid hard capsule of maintenance are conveniently carried out to capsule.
The sampling device of solid hard capsule of the present invention, including rack, upper rack install horizontal translation device, water
Lifting gear is installed on the top of the front fixed mounting plate of average moving device, the front face of mounting plate, and a transfer block is installed in lower part,
Lifting gear can drive the N that its underpart is installed simultaneously1Root is discharged mandril and upper and lower displacement occurs, and N is arranged in transfer block2A through-hole, machine
Sampling box is installed, sampling box is equipped with N in the middle part of frame3A mutually independent cavity, frame lower install N4On root can occur simultaneously
The quantity of the push-in mandril of bottom offset, the die hole of capsule filler cope plate is N, N=N1=N2=N3=N4, above-mentioned through-hole, row
The arrangement for going out mandril, the cavity of sampling box and push-in mandril is identical as the arrangement of die hole, and through-hole is identical as the aperture of die hole.
Preferably, the space of the cavity of the sampling box is 5 times of the space of the die hole or more, can be held in this way
The capsule that 5 times or more than 5 times sequential sampling obtain.
Preferably, the horizontal translation device is horizontal translation cylinder, the cylinder rod of horizontal translation cylinder and mounting plate
Plate face is fixedly connected afterwards.
Preferably, the lifting gear is the first lifting cylinder, and it is solid that first is equipped in the cylinder rod of the first lifting cylinder
Fixed board, discharge mandril are mounted on the lower face of the first fixed plate.
Preferably, the frame lower installs the second lifting cylinder, and drives push-in mandril by the second lifting cylinder
Upper and lower displacement occurs.Wherein, the second fixed plate is installed, push-in mandril is mounted on the second fixed plate on second lifting cylinder
Upper face on.
It is further preferred that the sampling box is dismantled and assembled in rack.Sampling is realized using following scheme in the present invention
Fast assembling-disassembling of the box in rack：It is equipped with installation otic placode in the both sides of the sampling box, installs and is equipped with bayonet on otic placode, it is right
Answer bayonet that two buckles are set in rack, buckle is mutually clamped with bayonet.
The operation principle and process of the sampling device of above-mentioned solid hard capsule is as follows：
1) in initial position, the template equipped with capsule reaches to be stopped below transfer block, and horizontal translation cylinder is at this time
Retraction position, the first lifting cylinder in upper end, the through-hole of the discharge mandril of top, the push-in mandril of lower section and transfer block with
The die hole of template corresponds；
2) when starting sampling, the second lifting cylinder driving push-in mandril rises, and is inserted into template in corresponding die hole, will
Capsule is from the corresponding through-hole of template push-in transfer block；
3) the second lifting cylinder driving push-in mandril moves down, and the ventilation of horizontal translation cylinder is stretched out, and drives transfer block to move to and takes
Above sample box, at this point, the cavity on the through-hole and sampling box of transfer block corresponds；
4) the first lifting cylinder is ventilated, and drives discharge mandril to fall, it is right in sampling box that transfer capsule in the block is pushed into
In the cavity answered；
5) horizontal translation cylinder and the first lifting cylinder lead to reversed gas, and entire sampling device is made to return initial position, into
Row is sampled next time.
Due to being provided with the one-to-one cavity of die hole with template in sampling box, taken out in corresponding die hole to store
Therefore capsule can realize automatic sampling by this sampling device, and the real-time online sampling of capsule may be implemented,
Subsampling operation is more convenient, without artificial, to reduce the labor intensity of operator.
It, can be to the capsule in sampling box in each cavity after having carried out continuous several times sampling work by this sampling device
Agent is weighed respectively, so as to targetedly find the problem, and is adjusted, make a concrete analysis of, adjustment process such as
Under：
If 1, the average weight of capsule is larger with standard weights difference in each cavity in sampling box, show powder disk
In the solid drugs uniformity there are problems, at this time use conventional method improve powder disk in solid drugs the uniformity；
If 2, on sampling box only there are one in (or several) cavity capsule average weight and standard weights difference compared with
Greatly, then it is shown to be in the corresponding sampling probe of the cavity and there are problems that blanking is not smooth or sampling probe is blocked by solid drugs,
Maintenance personal only needs have what is be directed to repair several sampling probes of problems at this time, all compared to tradition maintenance
The operation of sampling probe reduces workload, reduces labor intensity, while saving the repair time, improving maintenance efficiency, energy
It is enough to return to normal production faster.
Except above-mentioned points, sampling device of the present invention is flexible and changeable, and applicability is wide, and the template of different number die hole all may be used
Using when, application only need to by the through-hole of transfer block, sampling box cavity, push-in mandril, the quantity of mandril is discharged and arrangement be set
It counts into consistent with the die hole of template.
Possessed advantageous effect is the present invention compared with prior art：
1, it may be implemented to sample automatically through the invention, while the real-time online sampling of capsule may be implemented, be not necessarily to people
Work reduces the labor intensity of operator, keeps subsampling operation more convenient；
It 2, can be to the capsule in sampling box in each cavity after having carried out continuous several times sampling work through the invention
It weighs, so as to targetedly find the problem, and is adjusted respectively, all sampling probes are overhauled compared to tradition
Operation, reduce workload, reduce labor intensity, while saving the repair time, improving maintenance efficiency, can be faster
Return to normal production.
Description of the drawings
Fig. 1 is the structural schematic diagram of the present invention；
Fig. 2 is the structural schematic diagram of template；
Fig. 3 is the structural schematic diagram of transfer block；
Fig. 4 is the structural schematic diagram of sampling box.
In figure：1, horizontal translation cylinder；2, mounting plate；3, the first lifting cylinder；4, the first fixed plate；5, mandril is discharged；
6, through-hole；7, transfer block；8, sampling box；9, rack；10, it is pushed into mandril；11, the second fixed plate；12, the second lifting cylinder；13、
Capsule；14, template；15, die hole；16, cavity；17, otic placode is installed；18, bayonet.
Specific implementation mode
The embodiment of the present invention is described further below in conjunction with the accompanying drawings：
As shown in Figure 1,9 top of the rack installation horizontal translation dress of the sampling device of solid hard capsule of the present invention
It sets, the front fixed mounting plate 2 of horizontal translation device, lifting gear, lower part installation one are installed in the top of the front face of mounting plate 2
Transfer block 7, lifting gear can drive the N that its underpart is installed simultaneously1Root is discharged mandril 5 and upper and lower displacement occurs, and is arranged in transfer block 7
N2A through-hole 6 (as shown in Figure 3), 9 middle part of rack are equipped with sampling box 8, and sampling box 8 is equipped with N3A mutually isolated cavity 16,
It is equipped with installation otic placode 17 in the both sides of sampling box 8 simultaneously, installing has bayonet 18 on otic placode 17, the structure of sampling box 8 is specifically such as
Shown in Fig. 4, bayonet 18 is mutually clamped with the buckle in rack 9, is easy to implement fast assembling-disassembling of the sampling box 8 in rack 9, rack
N is installed 9 lower parts4The push-in mandril 10 of upper and lower displacement, the quantity of the die hole 15 of capsule filler cope plate 14 can occur simultaneously for root
For N, N=N1=N2=N3=N4, the structure of template 14 as shown in Fig. 2, above-mentioned through-hole 6, discharge mandril 5, sampling box 8 cavity
16 and push-in mandril 10 arrangement it is identical as the arrangement of die hole 15, through-hole 6 is identical as the aperture of die hole 15.
In the present embodiment, the space of the cavity 16 of sampling box 8 is 5 times of (i.e. lists of sampling box 8 in the space of the die hole 15
16 volume of a cavity is 5 times of 15 volume of single die hole), the capsule 13 that 5 sequential sampling obtains can be held in this way；
Horizontal translation device uses horizontal translation cylinder 1, the cylinder rod of horizontal translation cylinder 1 to be fixedly connected with the rear plate face of mounting plate 2；It rises
Falling unit uses the first lifting cylinder 3, and the first fixed plate 4 is equipped in the cylinder rod of the first lifting cylinder 3, and discharge mandril 5 is installed
On the lower face of the first fixed plate 4；The second lifting cylinder 12 is installed in 9 lower part of rack, and second is installed on the second lifting cylinder 12
Fixed plate 11, push-in mandril 10 are mounted on the upper face of the second fixed plate 11, in this way being capable of band by the second lifting cylinder 12
Upper and lower displacement occurs for dynamic push-in mandril 10.
The operation principle and process of sampling device described in the present embodiment is as follows：
1) in initial position, the template 14 equipped with capsule 13 reaches 7 lower section of transfer block and stops, at this time horizontal translation cylinder
1 is in retraction position, and the first lifting cylinder 3 is in upper end, the discharge mandril 5 of top, the push-in mandril 10 and transfer block 7 of lower section
Through-hole 6 with the die hole of template 14 15 correspond；
2) when starting sampling, the second lifting cylinder 12 driving push-in mandril 10 rises, and is inserted into corresponding mould in template 14
In hole 15, capsule 13 is pushed into from template 14 in 7 corresponding through-hole 6 of transfer block；
3) the second lifting cylinder 12 driving push-in mandril 10 moves down, and the ventilation of horizontal translation cylinder 1 is stretched out, and transfer block 7 is driven
8 top of sampling box is moved to, at this point, the through-hole 6 of transfer block 7 is corresponded with the cavity 16 on sampling box 8；
4) the first lifting cylinder 3 is ventilated, and drives discharge mandril 5 to fall, the capsule 13 in transfer block 7 is pushed into sampling box
In 8 in corresponding cavity 16；
5) horizontal translation cylinder 1 and the first lifting cylinder 3 lead to reversed gas, and entire sampling device is made to return initial position,
It is sampled next time.
Due to being provided with the 15 one-to-one cavity 16 of die hole with template 14 in sampling box 8, to store corresponding die hole
Therefore the capsule 13 taken out in 15 can realize automatic sampling, and capsule 13 may be implemented by this sampling device
Real-time online is sampled, and subsampling operation is more convenient, without artificial, to reduce the labor intensity of operator.
It, can be in each cavity 16 in sampling box 8 after having carried out continuous several times sampling work by this sampling device
Capsule 13 is weighed respectively, so as to targetedly find the problem, and is adjusted, and is made a concrete analysis of, is adjusted
Process is as follows：
If 1, the average weight of capsule 13 is larger with standard weights difference in each cavity 16 in sampling box 8, table
There are problems for the solid drugs uniformity in bright powder disk, and the uniformity for using conventional method to improve solid drugs in powder disk at this time is
It can；
If 2, on sampling box 8 only there are one in (or several) cavity 16 13 average weight of capsule and standard weights it is poor
It is not larger, then it is shown to be in the 16 corresponding sampling probe of cavity that there are blanking is not smooth or sampling probe blocked by solid drugs
Problem, at this time maintenance personal only need there is what is be directed to repair several sampling probes of problems, compared to tradition inspection
The operation for repairing all sampling probes reduces workload, reduces labor intensity, while saving the repair time, improving repair
Efficiency can return to normal production faster.
Except above-mentioned points, sampling device of the present invention is flexible and changeable, and applicability is wide, the template 14 of different number die hole 15
It can all apply, it only need to be by cavity 16, push-in mandril 10, the discharge mandril 5 in the through-hole 6 of transfer block 7, sampling box 8 when application
Quantity and arrangement are designed to consistent with the die hole of template 14 15.
Claims (8)
1. a kind of sampling device of solid hard capsule, it is characterised in that：Including rack (9), horizontal translation is installed on rack (9) top
The top of device, the front fixed mounting plate (2) of horizontal translation device, the front face of mounting plate (2) is installed by lifting gear, lower part
One transfer block (7) is installed, lifting gear can drive the N that its underpart is installed simultaneously1Root is discharged mandril (5) and upper and lower displacement occurs, in
N is arranged on (7) in switch block2A through-hole (6), rack (9) middle part are equipped with sampling box (8), and sampling box (8) is equipped with N3It is a mutually every
From cavity (16), rack (9) lower part install N4The push-in mandril (10) of upper and lower displacement can occur simultaneously for root, on capsule filler
The quantity of the die hole (15) of template (14) is N, N=N1=N2=N3=N4, above-mentioned through-hole (6), discharge mandril (5), sampling box
(8) arrangement of cavity (16) and push-in mandril (10) is identical as the arrangement of die hole (15), the hole of through-hole (6) and die hole (15)
Diameter is identical.
2. the sampling device of solid hard capsule according to claim 1, it is characterised in that：The sky of the sampling box (8)
The space of chamber (16) is 5 times or more of the space of the die hole (15).
3. the sampling device of solid hard capsule according to claim 1, it is characterised in that：The horizontal translation device is
The cylinder rod of horizontal translation cylinder (1), horizontal translation cylinder (1) is fixedly connected with the rear plate face of mounting plate (2).
4. the sampling device of solid hard capsule according to claim 1, it is characterised in that：The lifting gear is first
Lifting cylinder (3), the first fixed plate (4) is equipped in the cylinder rod of the first lifting cylinder (3), and discharge mandril (5) is mounted on first
On the lower face of fixed plate (4).
5. the sampling device of solid hard capsule according to claim 1, it is characterised in that：Rack (9) lower part peace
The second lifting cylinder (12) is filled, and drives push-in mandril (10) that upper and lower displacement occurs by the second lifting cylinder (12).
6. according to the sampling device for the solid hard capsule that claim 5 is stated, it is characterised in that：Second lifting cylinder (12)
The second fixed plate of upper installation (11), push-in mandril (10) are mounted on the upper face of the second fixed plate (11).
7. according to the sampling device of any solid hard capsule of claim 1~6, it is characterised in that：The sampling box
(8) dismantled and assembled in rack (9).
8. the sampling device of solid hard capsule according to claim 7, it is characterised in that：The two of the sampling box (8)
Side is equipped with installation otic placode (17), and bayonet (18) is equipped on installation otic placode (17), and corresponding bayonet (18) is arranged two in rack (9)
Buckle, buckle are mutually clamped with bayonet (18).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610654663.4A CN106124241B (en) | 2016-08-10 | 2016-08-10 | The sampling device of solid hard capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610654663.4A CN106124241B (en) | 2016-08-10 | 2016-08-10 | The sampling device of solid hard capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106124241A CN106124241A (en) | 2016-11-16 |
| CN106124241B true CN106124241B (en) | 2018-08-07 |
Family
ID=57257789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610654663.4A Active CN106124241B (en) | 2016-08-10 | 2016-08-10 | The sampling device of solid hard capsule |
Country Status (1)
| Country | Link |
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| CN (1) | CN106124241B (en) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0000314D0 (en) * | 2000-01-31 | 2000-01-31 | Astrazeneca Ab | Apparatus and method of analysis |
| JP4154275B2 (en) * | 2002-04-23 | 2008-09-24 | ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Device for weighing drug containers |
| FR2904114B1 (en) * | 2006-07-21 | 2008-10-17 | Biocode Hycel France Sa Sa | CARTRIDGE FOR REACTIVE PRODUCTS FOR USE IN ANALYTICAL APPARATUSES, CARRIER FOR RECEIVING THIS CARTRIDGE, AND ANALYSIS ASSEMBLY COMPRISING SAID CARTRIDGE AND HOLDER |
| CN201225983Y (en) * | 2008-02-28 | 2009-04-22 | 唐有福 | Detection device for hard capsule |
| CN101776615B (en) * | 2009-12-24 | 2011-10-26 | 丹东金丸集团有限公司 | Full-automatic capsule detection machine |
| CN201583505U (en) * | 2009-12-24 | 2010-09-15 | 丹东金丸集团有限公司 | Full-automatic capsule detection machine |
| CN201897575U (en) * | 2010-07-01 | 2011-07-13 | 潮州市强基制药厂 | Capsule testing machine |
| CN102430528A (en) * | 2011-06-23 | 2012-05-02 | 新昌县希克自动化设备有限公司 | Rotary conveying mechanism of medicinal capsule screening machine |
| CN202421083U (en) * | 2011-12-22 | 2012-09-05 | 新昌县希克自动化设备有限公司 | Rotation delivery device of capsule detector |
| CN104007279B (en) * | 2014-06-04 | 2016-05-04 | 上海宏莘科技发展有限公司 | The pressure-off formula charging of automatic sampler moves material discharge system |
| CN105004576B (en) * | 2015-07-31 | 2017-11-10 | 深圳市检验检疫科学研究院 | Sampling sample-adding all-in-one |
| CN204964236U (en) * | 2015-09-14 | 2016-01-13 | 东阿阿胶股份有限公司 | Novel for measuring instrument of soft capsule |
| CN205426935U (en) * | 2015-11-05 | 2016-08-03 | 南通诺赛自动化科技有限公司 | External detection self -reacting device |
| CN205941046U (en) * | 2016-08-10 | 2017-02-08 | 山东新马制药装备有限公司 | Sampling equipment of solid ebonite bag |
-
2016
- 2016-08-10 CN CN201610654663.4A patent/CN106124241B/en active Active
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|---|---|
| CN106124241A (en) | 2016-11-16 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Sampling equipment for solid hard capsules Effective date of registration: 20221017 Granted publication date: 20180807 Pledgee: Zibo sub branch of qishang Bank Co.,Ltd. Pledgor: SHANDONG SMA PHARMATECH CO.,LTD. Registration number: Y2022980018459 |
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