CN106110410A - Effectively alleviate the condom of orchiodynia - Google Patents

Effectively alleviate the condom of orchiodynia Download PDF

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Publication number
CN106110410A
CN106110410A CN201610754657.6A CN201610754657A CN106110410A CN 106110410 A CN106110410 A CN 106110410A CN 201610754657 A CN201610754657 A CN 201610754657A CN 106110410 A CN106110410 A CN 106110410A
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Prior art keywords
condom
chinese medicine
parts
medicine composition
orchiodynia
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CN201610754657.6A
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Inventor
胡智强
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GUILIN HBM HEALTHCARES Inc
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GUILIN HBM HEALTHCARES Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses the condom of a kind of effective alleviation orchiodynia, including condom substrate and Chinese medicine composition, it is characterised in that: with the total restatement of condom, the weight content of Chinese medicine composition is 0.01～0.05%；Described Chinese medicine composition is made up of the raw material of following weight portion: Radix Sophorae Tonkinensis 8～15 parts, Radix Cynanchi Paniculati 2～5 parts, Flos Daturae 1～4 parts, Radix Aconiti 1～3 parts, Fructus Foeniculi 2～4 parts.The present invention adds Chinese medicine composition in condom, and patient is when using condom, and penis is in congestive state, the osmotic absorption of Chinese medicine can be promoted, peripheral nerve endings effect can not only be suppressed to ease the pain, the pain caused by inflammatory growth of secondary can be suppressed again, thus significantly alleviate orchiodynia.

Description

Effectively alleviate the condom of orchiodynia
Technical field
The present invention relates to a kind of condom, be specifically related to the condom of a kind of effective alleviation orchiodynia.
Background technology
Chronic Orchialgia is defined as tip or persistence is unilateral or bilateral testes pain is uncomfortable, and the course of disease was more than 3 months, significantly Affect the daily life of patient.Owing to painful area is not only limited to testis, epididymis, the other structure of testis and essence also can be involved Rope, therefore it is believed that this disease should named " chronic scrotum content pain " may be more accurate.Facing of Chronic Orchialgia Bed symptom overlaps with a lot of pelvic pain syndromes, can be ranged the part of the latter.Along with clinic is to this disease Understanding deepens continuously, and increasing Chronic Orchialgia patient is made a definite diagnosis.Chronic Orchialgia can betide any age, but many Number is between 35～40 years old.In the U.S., Chronic Orchialgia is one of modal urological diseases of soldier male.Chronic testis Pain is the most common in Europe, and Switzerland Urology Surgery doctor reports that this disease accounts for the 2.5% of all Urology Surgery patients.Chronic Orchialgia Once make a definite diagnosis, should actively seek the specific cause of disease, treat for the cause of disease；If but can not find the definite cause of disease, could examine Breaking as idiopathic Chronic Orchialgia, Therapeutic Method includes expectant treatment and operative treatment.The conservative of idiopathic Chronic Orchialgia is controlled Treatment method includes nonsteroidal antiinflammatory drug, antidepressants, anticonvulsant, antianxiety drugs etc., and it is bigger that these medicines exist side effect Shortcoming, and costly, it is relatively big then to there is aggressive in operative treatment, and the shortcoming that risk is bigger.
Summary of the invention
The technical problem to be solved is to provide the condom of a kind of effective alleviation idiopathic Chronic Orchialgia, becomes This is cheap, effective.
The technical scheme that the present invention provides is to provide the condom of a kind of effective alleviation orchiodynia, including condom substrate and Chinese medicine composition, with the total restatement of condom, the weight content of Chinese medicine composition is 0.01～0.05%；
Described Chinese medicine composition is made up of the raw material of following weight portion: Radix Sophorae Tonkinensis 8～15 parts, Radix Cynanchi Paniculati 2～5 parts, Man Tuo Sieve 1～4 parts, Radix Aconiti 1～3 parts, Fructus Foeniculi 2～4 parts.
The present invention adds after selecting Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Flos Daturae, Radix Aconiti and Fructus Foeniculi 5 taste Chinese crude drugs carrying out compatibility totally In condom substrate, patient is when using condom, and penis is in congestive state, and blood circulation is very fast, and medicine can be quickly Penis osmotic absorption, effectively reduces NO content in blood, owing to NO is a kind of second message,second messenger's neurotransmitter, is that cell-tocell passes The important regulatory factor passed, NO is that it need not any intervening mechanism and spreads rapidly as the maximum feature of messenger molecule By biomembrane, the information that a cell produces is delivered in the cell of surrounding.One of mechanism that NO plays a role is exactly Improve the cyclic guanylic acid level of target cell, i.e. NO-cGMP approach.NO is by nitricoxide synthase (NOS) catalysis L-arginine Generating, in neurocyte, NOS is a kind of Ca2+Dependent structure enzyme, Ca2+Concentration increases can promote that NO synthesizes, Pain Process In intracellular Ca2+Concentration increases, and can promote the synthesis of NO, and NO may also participate in the Gene regulation of target cell, and NO itself is to gene Though transcribing without impact, but it can amplifying the Ca2+ oscillations in neurocyte, the meaning of this amplification is at intracellular calcium water Being even more important in the case of putting down relatively greatly, can make the faintest, easy uncared-for information is amplified, thus causes intracellular Significantly physiological change, therefore, reduces NO content in blood and just can suppress testicular pain.
It addition, the nerve that spermatic cord is within and around changes or is in trans activation state, it it is idiopathic Chronic Orchialgia A key factor, the compositions of above-mentioned 5 taste medical materials can also be distributed on cremaster, deferent duct outer fascia, periarterial The Afferent neuronal pathways being in trans activation state in tissue and spermatic cord peripheral adipose tissue is blocked, thus significantly alleviates testis The symptom of pain.
As preferably, the weight content of described Chinese medicine composition is 0.01～0.02%.
It is further preferred that the weight content of described Chinese medicine composition is 0.02%.
The preparation method of described Chinese medicine composition is: each raw material pulverizing be placed in container, extracting in water 2 times, first Secondary addition inventory 8～the water extraction 2h of 10 times, second time adds inventory 6～the water extraction 1.5h of 8 times, merges twice extraction Liquid, filters, and it is the extractum of 1.2～1.25 that filtrate is concentrated into relative density at 60 DEG C, is spray-dried, to obtain final product.
Described substrate is latex.
The present invention adds Chinese medicine composition in condom, and patient is when using condom, and penis is in congestive state, can To promote the osmotic absorption of Chinese medicine, peripheral nerve endings effect can not only be suppressed to ease the pain, the inflammatory of secondary can be suppressed again Pain caused by growth, thus significantly alleviate orchiodynia.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
1) Radix Sophorae Tonkinensis 8kg, Radix Cynanchi Paniculati 2kg, Flos Daturae 1kg, Radix Aconiti 1kg and Fructus Foeniculi 2kg pulverizing is placed in container, Extracting in water 2 times, adds the water extraction 2h of inventory 8 times for the first time, and second time adds the water extraction 1.5h of inventory 6 times, closes And twice extracting solution, to filter, it is the extractum of 1.2 that filtrate is concentrated into relative density at 60 DEG C, is spray-dried, obtains Chinese medicine composition Thing.
2) 99.99kg latex is centrifuged, adds 0.01kg Chinese medicine composition, mixing, send into head tank.
3) mold cleaning, dries, and impregnation is starched, and dries 50min at 100 DEG C, and impregnation is starched again, 60 DEG C of drying 50min, crimping, and 100 Drying 50min, the demoulding, foam washing 30min at 50 DEG C at DEG C, dry 1h for 120 DEG C, the packaging that oils is effectively alleviates keeping away of orchiodynia Pregnant set.
Embodiment 2
1) Radix Sophorae Tonkinensis 15kg, Radix Cynanchi Paniculati 5kg, Flos Daturae 4kg, Radix Aconiti 3kg and Fructus Foeniculi 4kg pulverizing is placed on container In, extracting in water 2 times, add the water extraction 2h of inventory 10 times for the first time, second time adds the water extraction of inventory 8 times 1.5h, merges twice extracting solution, filters, and it is the extractum of 1.25 that filtrate is concentrated into relative density at 60 DEG C, is spray-dried, in obtaining Drug composition.
2) 99.95kg latex is centrifuged, adds 0.05kg Chinese medicine composition, mixing, send into head tank.
3) mold cleaning, dries, and impregnation is starched, and dries 50min at 100 DEG C, and impregnation is starched again, 60 DEG C of drying 50min, crimping, and 100 Drying 50min, the demoulding, foam washing 30min at 50 DEG C at DEG C, dry 1h for 120 DEG C, the packaging that oils is effectively alleviates keeping away of orchiodynia Pregnant set.
Embodiment 3
1) Radix Sophorae Tonkinensis 12kg, Radix Cynanchi Paniculati 4kg, Flos Daturae 2kg, Radix Aconiti 2kg and Fructus Foeniculi 3kg pulverizing is placed on container In, extracting in water 2 times, add the water extraction 2h of inventory 9 times for the first time, second time adds the water extraction 1.5h of inventory 7 times, Merging twice extracting solution, filter, it is the extractum of 1.23 that filtrate is concentrated into relative density at 60 DEG C, is spray-dried, obtains Chinese drug-treated group Compound.
2) 99.98kg latex is centrifuged, adds 0.02kg Chinese medicine composition, mixing, send into head tank.
3) mold cleaning, dries, and impregnation is starched, and dries 50min at 100 DEG C, and impregnation is starched again, 60 DEG C of drying 50min, crimping, and 100 Drying 50min, the demoulding, foam washing 30min at 50 DEG C at DEG C, dry 1h for 120 DEG C, the packaging that oils is effectively alleviates keeping away of orchiodynia Pregnant set.
Embodiment 4
1) Radix Sophorae Tonkinensis 8kg, Radix Cynanchi Paniculati 5kg, Flos Daturae 1kg, Radix Aconiti 3kg and Fructus Foeniculi 2kg pulverizing is placed in container, Extracting in water 2 times, adds the water extraction 2h of inventory 10 times for the first time, and second time adds the water extraction 1.5h of inventory 6 times, closes And twice extracting solution, to filter, it is the extractum of 1.25 that filtrate is concentrated into relative density at 60 DEG C, is spray-dried, obtains Chinese medicine composition Thing.
2) 99.9kg latex is centrifuged, adds 0.01kg Chinese medicine composition, mixing, send into head tank.
3) mold cleaning, dries, and impregnation is starched, and dries 50min at 100 DEG C, and impregnation is starched again, 60 DEG C of drying 50min, crimping, and 100 Drying 50min, the demoulding, foam washing 30min at 50 DEG C at DEG C, dry 1h for 120 DEG C, the packaging that oils is effectively alleviates keeping away of orchiodynia Pregnant set.
Experimental example
1, clinical data
Selecting clinical idiopathic Chronic Orchialgia patient 200 example, the age is 20～48 years old, 34 years old mean age.With one side Or bilateral testes pain is main, some patients is uncomfortable with lumbar and back pain, obvious with testis dull pain or pendant pain.Anorchia wound, hands The medical histories such as art history, anorchia inflammation and epididymitis.Health check-up, ultrasonic examination discovery without exception, prostatic fluid is conventional and cultivates all normal, Fall ill equal ＞ 5 months.It is randomly divided into 5 groups, often organizes 40 examples, respectively experimental group 1～4 and matched group.Each group patient is all without medication Taboo, two groups of ages, the course of disease, medication history are roughly the same, and no significant difference has comparability.
Experimental group 1～4 uses the condom of embodiment 1～4 respectively, and treatment cycle is 30 days, within average 3 days, uses once. Matched group nimesulide dispersible tablet (power U.S.A send, Hubei Sibao Pharmaceutical Co., Ltd, traditional Chinese medicines quasi-word H20010734) 100mg every time, Every day twice, it is administered orally after the meal, takes 30 days continuously.
2, Pain scale evaluation standard
Treat 30 days, record pain and the discomfort of patient main suit respectively.Score by 4 grades of point systems, 0 point: without pain；1 point: Mild pain；2 points: moderate pain；3 points: severe pain.
3, clinical efficacy standard
× 100% is scored before therapeutic index=(scoring after scoring before treatment-treating)/treatment
Clinic control: pain symptom disappears substantially, therapeutic index >=80%；
Effective: pain is substantially alleviated, 60%≤therapeutic index ＜ 80%；
Effective: pain relief, 20%≤therapeutic index ＜ 60%；
Invalid: pain intensity does not weakens, attack times or persistent period do not reduce, therapeutic index ＜ 20%.
4, therapeutic outcome
Compare with matched group, * P ＜ 0.05；* P ＜ 0.01.

Claims (5)

1. effectively alleviate the condom of orchiodynia, including condom substrate and Chinese medicine composition, it is characterised in that: total with condom Restatement, the weight content of Chinese medicine composition is 0.01～0.05%；
Described Chinese medicine composition is made up of the raw material of following weight portion: Radix Sophorae Tonkinensis 8～15 parts, Radix Cynanchi Paniculati 2～5 parts, Flos Daturae 1～ 4 parts, Radix Aconiti 1～3 parts, Fructus Foeniculi 2～4 parts.
The condom of effective alleviation orchiodynia the most according to claim 1, it is characterised in that: the weight of described Chinese medicine composition Amount content is 0.01～0.02%.
The condom of effective alleviation orchiodynia the most according to claim 1, it is characterised in that: the weight of described Chinese medicine composition Amount content is 0.02%.
4. according to the condom effectively alleviating orchiodynia according to any one of claims 1 to 3, it is characterised in that: in described The preparation method of drug composition is: each raw material pulverizing be placed in container, extracting in water 2 times, add for the first time inventory 8～ The water extraction 2h of 10 times, second time adds inventory 6～the water extraction 1.5h of 8 times, merges twice extracting solution, filters, and filtrate is dense Being reduced to relative density at 60 DEG C is the extractum of 1.2～1.25, is spray-dried, to obtain final product.
The condom of effective alleviation orchiodynia the most according to claim 1, it is characterised in that: described substrate is latex.
CN201610754657.6A 2016-08-29 2016-08-29 Effectively alleviate the condom of orchiodynia Pending CN106110410A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610754657.6A CN106110410A (en) 2016-08-29 2016-08-29 Effectively alleviate the condom of orchiodynia

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897791A (en) * 2010-07-10 2010-12-01 孙一凡 Medicament for treating testiclar gall
CN102716184A (en) * 2012-07-02 2012-10-10 苏州纳晶医药技术有限公司 Chinese medicinal composition and application thereof
CN103462742A (en) * 2013-09-25 2013-12-25 桂林恒保健康用品有限公司 Condom for prolonging sexual stamina

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897791A (en) * 2010-07-10 2010-12-01 孙一凡 Medicament for treating testiclar gall
CN102716184A (en) * 2012-07-02 2012-10-10 苏州纳晶医药技术有限公司 Chinese medicinal composition and application thereof
CN103462742A (en) * 2013-09-25 2013-12-25 桂林恒保健康用品有限公司 Condom for prolonging sexual stamina

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