CN106110372A - A kind of collagen sponge dressing containing medical base fabric - Google Patents

A kind of collagen sponge dressing containing medical base fabric Download PDF

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Publication number
CN106110372A
CN106110372A CN201610602007.XA CN201610602007A CN106110372A CN 106110372 A CN106110372 A CN 106110372A CN 201610602007 A CN201610602007 A CN 201610602007A CN 106110372 A CN106110372 A CN 106110372A
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base fabric
collagen
medical base
medical
collagen sponge
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Inventor
刘富俊
孙海胜
孙莉嫚
李好雨
杨秀甫
杨中科
杨安顺
胡正洋
蒋小龙
何龙
金玉
叶东
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Suzhou Jing Zhuo Bioisystech Co Ltd
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Suzhou Jing Zhuo Bioisystech Co Ltd
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Priority to CN201610602007.XA priority Critical patent/CN106110372A/en
Publication of CN106110372A publication Critical patent/CN106110372A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a kind of collagen sponge dressing containing medical base fabric, formed by lyophilization and heat cross-linking with collagen solution by medical base fabric, medical base fabric and collagen solution form the collagen sponge containing medical base fabric after lyophilization, without other compositions between medical base fabric and collagen sponge.This collagen sponge dressing containing medical base fabric has good water absorption, breathability and mechanical property; attaching is good; shrinkage factor is low; conveniently fix during use; it is easy to after using remove, without other materials, there is good biocompatibility; it is applicable to various skin wound, there is protection and promote the effect of wound repair.

Description

A kind of collagen sponge dressing containing medical base fabric
Technical field
The present invention relates to protection and promote the medical material of wound repair, a kind of collagen sponge containing medical base fabric Dressing.
Background technology
Collagen protein, as one of the main component of extracellular matrix, has reduced immunogenicity and good bio-compatible Property, it is widely used in wound repair process.The sponge dressing that collagen protein is made can absorb wound exudate, has the most ventilative Property and comfortableness, also promote wound repair while protection wound surface, be a kind of preferably Wound dressing.But the most also There are some problems, as mechanical strength is inadequate, its intrinsic morphosis can be changed after imbibition is swelling, be unfavorable for fixing, and every Limited etc. from effect.Therefore, collagen sponge and other synthesis macromolecules or natural macromolecular material are combined by current many employings Method, improves the deficiency that single collagen sponge exists in the application.
At present with collagen sponge and medical base fabric group all-in-one-piece dressing, it is all to be pasted onto collagen sponge to scribble natural rubber In the medical scrim material of glue cream slurry or medical hot melt adhesive, these medical adhesives make the biocompatibility of dressing and comfortableness become Difference, easily causes allergy.And after coating medical adhesive, the breathability of medical base fabric reduces, and for the wound surface that sepage is more, is unfavorable for oozing The discharge of liquid, thus still have necessity of improvement.
Summary of the invention
It is an object of the invention to improve existing collagen sponge performance, it is provided that a kind of have good water absorption, breathability With mechanical property, attach property good, shrinkage factor is low, conveniently fix, be easy to remove, have good biocompatibility containing medical base fabric Collagen sponge dressing.
The collagen sponge dressing containing medical base fabric that the present invention provides, by medical base fabric with collagen solution by freezing Being dried and form, medical base fabric and collagen solution form the collagen sponge containing medical base fabric, medical base after lyophilization Without other compositions between cloth and collagen sponge.
Compared to pure collagen sponge, the present invention increases medical base fabric on the basis of collagen sponge so that it is mechanical property increases, Absorb wound exudate post-shrinkage ratio low, and attaching property is good, convenient fixing.Between medical base fabric and collagen sponge without rubber paste slurry or Other bonding materials such as medical hot melt, increase its water absorption and breathability, and biocompatibility is also more preferable, and are easy to clear after use Remove.
The crosslinking method that collagen sponge is conventional has chemical crosslinking and physical crosslinking, due to during chemical crosslinking crosslinking dose Residual, can affect the biocompatibility of dressing, and therefore we have selected heat cross-linking, belongs to physical crosslinking.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, described medical base fabric is medical adhesive-bonded fabric, hospital gauze Or medical white embryo cloth.
Owing to the connection between medical base fabric and collagen sponge bonds not by rubber paste slurry or medical hot melt adhesive, But being penetrated in the hole of medical base fabric by collagen solution, after lyophilization, both become one.Therefore for medical The selection of the material of base fabric, thickness, textile density etc. is the most extremely important, if select improper, then sponge and medical base after lyophilizing Lamination or wrinkle phenomenon easily occur between cloth, affects outward appearance and performance.
It is highly preferred that the above-mentioned collagen sponge dressing containing medical base fabric, described medical adhesive-bonded fabric be textile medical spun lacing without Spinning cloth, specification is 15～60g/m2.Medical adhesive-bonded fabric represents its thickness with unit are grammes per square metre.
Non-woven fabrics kind is more, can be divided into spun-laced nonwoven fabric, heat seal non-woven fabrics, needle punched non-woven fabrics etc. by its technique, wherein Spun-laced nonwoven fabric is by fine for high pressure water flow jet to one or more layers fleece, makes fiber the most entangled, thus Making fibre web be reinforced and possess certain strength, the fabric obtained is spun-laced nonwoven fabric.Non-woven fabrics by its composition material have cotton, The natural fibers such as fiber crops and other chemical fibres.Owing to textile spun-laced nonwoven fabric has more preferable water absorption, quality is soft, fluffy, Good permeability, production process relatively other non-woven fabrics are clean, therefore frequently as the constituent of medical dressing, can directly and wound surface and Contact skin.And owing to its quality is fluffy, it is simple to it is integrated with collagen solution lyophilizing, without being layered.
It is highly preferred that the above-mentioned collagen sponge dressing containing medical base fabric, described hospital gauze is medical absorbent cotton gauze, warp Yarn and weft yarn number are 21～50, and textile density is the warp yarn number of every 100mm and weft threads number is 70～150.
According to industry standard " YY 0331-2006 degreasing cotton gauze, the performance requirement of the viscose blended gauze of absorbent cotton and examination Proved recipe method " in definition, degreasing cotton gauze refer to through defat, bleach or dye, the tasteless plain weave cotton of purification, without substantially Cotton leaf, cotton seed hulls or other impurity.The more general gauze of degreasing cotton gauze has more preferable water absorption, is widely used in medical treatment row Industry.
Degreasing cotton gauze, represents the thickness of warp yarn and weft threads respectively with warp yarn count and weft yarn number, and numeral is the biggest, Yarn is the thinnest；Representing textile density with the warp yarn number in every 100mm and the weft threads number in every 100mm, numeral is the biggest, density The biggest.Therefore, warp yarn and weft threads thickness should be selected relatively uniform, the degreasing cotton gauze that textile density is moderate, beneficially collagen Solution penetrates into gauze hole, and lyophilizing aftershaping effect is more preferable.
It is highly preferred that the above-mentioned collagen sponge dressing containing medical base fabric, the model of described medical absorbent cotton gauze is following Any one: yarn count density is 21 × 21, and textile density is 120 × 100；Yarn count density is 21 × 32, and textile density is 110×100；Yarn count density is 32 × 32, and textile density is 120 × 120；Yarn count density is 40 × 40, and textile density is 100×120；Yarn count density is 40 × 40, and textile density is 120 × 120.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, collagen protein quality in described collagen aqueous solution Percentage concentration is 0.4～2.0%.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, before freezing, first medical base fabric is layered on lyophilizing mould Bottom pours collagen solution again into, or first pours collagen solution in lyophilizing mould into, then spreads on collagen solution surface Upper medical base fabric.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, when selecting first medical base fabric to be layered at the bottom of lyophilizing mould When the method for collagen solution is poured in portion again into, need first to be attached on lyophilizing mould, more medical base fabric with liquid moistening Pour collagen solution into；Described liquid is purified water, water for injection or other solution.If not fixing medical base fabric, then add When entering collagen solution, centre has bubble, has bubble, fold, and injustice after lyophilizing between collagen sponge and medical base fabric Whole, have lamination between sponge and medical base fabric time serious, affect its outward appearance, performance and use.Use liquid fixed party Face overcomes the problems referred to above, and liquid and collagen solution also have the good compatibility simultaneously, are not result in adding of unwanted contributions Add the negative effects brought.
It is highly preferred that the above-mentioned collagen sponge dressing containing medical base fabric, described volume is 150～400g/m2Medical Base fabric.If the amount of added liquid is very few, medical base fabric can not be completely fixed on lyophilizing mould, if too much, and can be to collagen solution There is certain diluting effect, affect the performance of sponge after lyophilizing.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, the method for described lyophilization and heat cross-linking is :- 80 DEG C of precooling 4h～8h ,-25 DEG C of primary drying 24h～48h, 10 DEG C of redryings 8h～16h.By lyophilizing sponge dressing 100 It is vacuum dried 24h～72h at DEG C and carries out heat cross-linking.
Preferably, the above-mentioned collagen sponge dressing containing medical base fabric, the thickness of described collagen sponge is 1～5mm.
There is advantages that
(1) present invention collagen sponge dressing containing medical base fabric, has preferable sorptivety and breathability, therein medical Sepage can be drawn to surface by base cloth layer, too much sepage is taken away by siphonage, therefore can provide phase for the reparation of wound surface To moistening environment, avoid the gathering of wound exudate, wound healing simultaneously.
(2) present invention collagen sponge dressing containing medical base fabric, has good mechanical property, and absorbs sepage or collagen Still can keep good form after the release of sponge enzymolysis, therefore wound surface is had the work that good protection and the isolation external world infect With.
(3) present invention collagen sponge dressing containing medical base fabric, can effectively facilitate proliferation and differentiation and the vascularization of cell, add Speed wound healing.
(4) present invention collagen sponge dressing containing medical base fabric, medical base fabric is firmly combined with collagen sponge, it is to avoid sponge Separate with medical base fabric after absorbing sepage.Meanwhile, when sepage more need more change dressings, can by base fabric and sponge dressing simultaneously Remove, reduce the damage to wound.
(5) present invention is containing the collagen sponge dressing of medical base fabric, and the sepage that can be used for wound surface absorbs it can also be used to various types of The protection of type damage wound surface and reparation.
(6) present invention collagen sponge dressing containing medical base fabric, size and thickness are controlled, and preparation method is simple, and technique becomes Ripe, it is easy to industrialization.
Accompanying drawing explanation
Fig. 1 is the collagen sponge dressing longitudinal profile structural representation containing medical base fabric provided by the present invention；
Fig. 2 is size before the water suction of common collagen sponge；
Fig. 3 is size after the water suction of common collagen sponge；
Fig. 4 is the front size of the water suction of the collagen sponge dressing containing medical base fabric of the present invention；
Fig. 5 be the present invention the collagen sponge dressing containing medical base fabric water suction after size.
Detailed description of the invention
In order to make those skilled in the art be more fully understood that the present invention program, below in conjunction with detailed description of the invention to this Bright it is described in further detail.
Refer to Fig. 1, the present invention collagen sponge dressing containing medical base fabric is made up of medical base cloth layer and collagen sponge layer. The area of medical base cloth layer is identical with collagen sponge layer with shape, generally circular in shape, square or any symmetry of medical base cloth layer Or it is asymmetrically shaped.Mould used when the molding of collagen sponge dressing different area specification can use lyophilizing, it is possible to Machinery cutting is used after lyophilizing.
Embodiment 1:
(1) collagen solution being diluted to collagen content is 0.4%.
(2) be 21 × 32 by yarn count density, textile density be 110 × 100 medical absorbent cotton gauze be cut into mould Size, is laid in mold bottom by the medical absorbent cotton gauze after cutting, calculates the area of medical absorbent cotton gauze, by 150g/ m2Ratio add purified water, make medical absorbent cotton gauze be close to mold bottom.
(3) lyophilizing: the collagen solution of 0.4% is poured in the mould being covered with medical absorbent cotton gauze, pre-in-80 DEG C Freeze 4h, in-25 DEG C of primary drying 24h, 10 DEG C of redryings 8h.I.e. obtain the collagen sponge that size is 50mm × 50mm × 2mm.
(4) crosslinking: put in vacuum drying oven by the collagen sponge containing medical base fabric after lyophilizing, at 100 DEG C, vacuum is done Dry 24h carries out heat cross-linking.
Embodiment 2:
(1) collagen aqueous solution being diluted to collagen content is 0.8%.
(2) be 32 × 32 by yarn count density, textile density be 120 × 120 medical absorbent cotton gauze be cut into mould Size, is laid in mold bottom by the medical absorbent cotton gauze after cutting, calculates the area of medical absorbent cotton gauze, by 200g/ m2Ratio add water for injection, make medical absorbent cotton gauze be close to mold bottom.
(3) lyophilizing: the collagen solution of 0.8% is poured in the mould being covered with medical absorbent cotton gauze, pre-at-80 DEG C Freezing 5h, at-25 DEG C of primary drying 30h, 10 DEG C of redryings 10h i.e. obtain the collagen sea that size is 50mm × 50mm × 3mm Continuous.
(4) crosslinking: put in vacuum drying oven by the collagen sponge containing medical base fabric after lyophilizing, at 100 DEG C, vacuum is done Dry 36h carries out heat cross-linking.
Embodiment 3:
(1) collagen aqueous solution being diluted to collagen content is 1.2%.
(2) be 40 × 40 by yarn count density, textile density be 100 × 120 medical absorbent cotton gauze be cut into mould Size, is laid in mold bottom by the medical absorbent cotton gauze after cutting, calculates the area of medical absorbent cotton gauze, by 300g/ m2Ratio add purified water, make medical absorbent cotton gauze be close to mold bottom.
(3) lyophilizing: the collagen solution of 1.2% is poured in the mould being covered with medical absorbent cotton gauze ,-80 DEG C of pre-coolings Freezing 6h, at-25 DEG C of primary drying 35h, 10 DEG C of redryings 12h i.e. obtain the collagen sponge that size is 50mm × 50mm × 5mm.
(4) crosslinking: put in vacuum drying oven by the collagen sponge containing medical base fabric after lyophilizing, is dried 48h at 100 DEG C Carry out heat cross-linking.
Embodiment 4:
(1) collagen aqueous solution being diluted to collagen content is 1.6%.
(2) it is 50g/m by grammes per square metre2Medical spun-laced nonwoven fabric is cut into 200mm × 200mm size, medical by after cutting Spun-laced nonwoven fabric is laid in the mold bottom of 200mm × 200mm, calculates the area of medical spun-laced nonwoven fabric, by 400g/m2Ratio Example adds purified water, makes medical spun-laced nonwoven fabric be close to mold bottom.
(3) lyophilizing: the collagen solution of 1.6% is poured in the mould being covered with medical spun-laced nonwoven fabric ,-80 DEG C of pre-coolings Freezing 7h, at-25 DEG C of primary drying 40h, 10 DEG C of redryings 14h i.e. obtain the collagen sea that size is 200mm × 200mm × 2mm Continuous.
(4) crosslinking: put in vacuum drying oven by the collagen sponge containing medical base fabric after lyophilizing, at 110 DEG C, vacuum is done Dry 60h carries out heat cross-linking.
(5) cutting: the collagen sponge containing medical base fabric is cut into 50mm × 50mm × 2mm size.
Embodiment 5:
(1) collagen aqueous solution being diluted to collagen content is 2%.
(2) it is 15g/m by grammes per square metre2Medical spun-laced nonwoven fabric is cut into 200mm × 200mm size, by the collagen protein of 2% Solution is poured in mould, then spreads 15g/m on collagen solution surface2Medical spun-laced nonwoven fabric.
(3) lyophilizing :-80 DEG C of precooling 8h, at-25 DEG C of primary drying 48h, 10 DEG C of redryings 16h i.e. obtain size and are The collagen sponge of 200mm × 200mm × 5mm.
(4) crosslinking: put in vacuum drying oven by the collagen sponge containing medical base fabric after lyophilizing, at 100 DEG C, vacuum is done Dry 72h carries out heat cross-linking.
(5) cutting: it is 50mm × 50mm × 5mm that the collagen sponge containing medical adhesive-bonded fabric is cut into size.Embodiment 6:
In testing example 1～5 preparation the water absorption of collagen sponge dressing containing medical base fabric, moisture-vapor transmission, The performance such as shrinkage factor, hot strength, the performance test results see table:
(1) water absorption computing formula: (m2-m1)/s × 100, sample quality after m2-water suction, g；Sample matter before m1-water suction Amount, g；S-sample area, cm2。
(2) moisture-vapor transmission computing formula: X=(W1-W2) × 1000 × 24/T, X-moisture-vapor transmission, unit is g.m-2.24h-1, the quality of W1-container, sample and liquid, unit is container after g, W2-experimental period, sample and the quality of liquid, Unit is g, T-time experimental period, and unit is hour (h).
(3) shrinkage factor: represent shrinkage factor with the rate of change of size before dressing water suction and after water suction.Common collagen sponge (by Collagen solution is made) with collagen sponge (abbreviation sponge dressing) water suction containing medical base fabric in the present invention before and after size Fig. 2～Fig. 5 is shown in change, and as can be known from the results, after the sponge dressing water suction in the present invention, size is far below almost without change, shrinkage factor Individually collagen sponge.
Collagen sponge dressing containing medical base fabric prepared by the present invention, adheres between medical base fabric and collagen sponge firmly, i.e. After making water suction or absorbing sepage, also will not be layered or come off between base fabric and sponge.During use, by the dressing one side containing collagen sponge After being affixed on wound surface, only need to paste medical adhesive tape outside compress and be fixed, without displacement between base fabric and sponge, convenient solid Fixed.When needs more change dressings or when removing it, base fabric and sponge can be removed simultaneously, and individually collagen sponge is due to it Mechanical property is poor, may there is removal not exclusively.
The explanation of above example is only intended to help to understand the core concept of the present invention.It should be pointed out that, for this technology For the those of ordinary skill in field, under the premise without departing from the principles of the invention, it is also possible to the present invention is carried out some improvement And modification, these improve and modify in the protection domain also falling into the claims in the present invention.

Claims (10)

1. the collagen sponge dressing containing medical base fabric, it is characterised in that by medical base fabric with collagen solution by cold Lyophilizing is dry and heat cross-linking forms, and medical base fabric and collagen solution form the collagen sea containing medical base fabric after lyophilization Silk floss, without other compositions between medical base fabric and collagen sponge.
Collagen sponge dressing containing medical base fabric the most according to claim 1, it is characterised in that described medical base fabric is doctor With non-woven fabrics, hospital gauze or medical white embryo cloth.
Collagen sponge dressing containing medical base fabric the most according to claim 2, it is characterised in that described medical adhesive-bonded fabric is Textile medical spun-laced nonwoven fabric, specification is 15～60g/m2。
Collagen sponge dressing containing medical base fabric the most according to claim 2, it is characterised in that described hospital gauze is doctor Being 21～50 with degreasing cotton gauze, warp thread and weft yarn number, textile density is the warp yarn number of every 100mm and weft threads number is 70～150.
Collagen sponge dressing containing medical base fabric the most according to claim 4, it is characterised in that described medical absorbent cotton yarn The model of cloth be following any one: yarn count density is 21 × 21, and textile density is 120 × 100；Yarn count density is 21 × 32 , textile density is 110 × 100；Yarn count density is 32 × 32, and textile density is 120 × 120；Yarn count density is 40 × 40 , textile density is 100 × 120；Yarn count density is 40 × 40, and textile density is 120 × 120.
Collagen sponge dressing containing medical base fabric the most according to claim 1, it is characterised in that described collagen protein is water-soluble In liquid, collagen protein quality percentage concentration is 0.4～2.0%.
Collagen sponge dressing containing medical base fabric the most according to claim 1, it is characterised in that before freezing, first will doctor It is layered on lyophilizing mold bottom by base fabric and pours collagen solution again into, or first in lyophilizing mould, pour collagen solution into, Medical base fabric is spread again on collagen solution surface.
Collagen sponge dressing containing medical base fabric the most according to claim 7, it is characterised in that when selecting first by medical base When cloth is layered on the method that lyophilizing mold bottom pours collagen solution again into, need first to be attached to freeze with liquid moistening by medical base fabric On dry mould, pour collagen solution the most again into；Described liquid is purified water, water for injection or other solution.
Collagen sponge dressing containing medical base fabric the most according to claim 8, it is characterised in that described volume is 150～400g/m2Medical base fabric.
Collagen sponge dressing containing medical base fabric the most according to claim 1, it is characterised in that described lyophilization and The method of heat cross-linking is: at-80 DEG C of precooling 4h～8h ,-25 DEG C of primary drying 24h～48h, 10 DEG C of redryings 8h～16h. Heat cross-linking is carried out by being vacuum dried 24h～72h at 100 DEG C of lyophilizing sponge.
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CN107399119A (en) * 2017-08-11 2017-11-28 恒天嘉华非织造有限公司 A kind of high-end hygienic material of graphene-based fiber and its preparation technology
CN108571862A (en) * 2017-03-07 2018-09-25 成都青山利康药业有限公司 A kind of freeze-drying stripping means of film

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CN101856516A (en) * 2010-05-25 2010-10-13 中国人民解放军总医院第一附属医院 Preparation of collagen-chitosan-laser micropore dermal matrix composite membranes
CN102049061A (en) * 2010-12-08 2011-05-11 苏州同科生物材料有限公司 Method for preparing chitosan collagen sponge burn dressing

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CN108571862A (en) * 2017-03-07 2018-09-25 成都青山利康药业有限公司 A kind of freeze-drying stripping means of film
CN107399119A (en) * 2017-08-11 2017-11-28 恒天嘉华非织造有限公司 A kind of high-end hygienic material of graphene-based fiber and its preparation technology

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Application publication date: 20161116