CN106110243A - A kind of Chinese medicine composition with analgesic activity - Google Patents

A kind of Chinese medicine composition with analgesic activity Download PDF

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Publication number
CN106110243A
CN106110243A CN201610522223.3A CN201610522223A CN106110243A CN 106110243 A CN106110243 A CN 106110243A CN 201610522223 A CN201610522223 A CN 201610522223A CN 106110243 A CN106110243 A CN 106110243A
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chinese medicine
composition
present
medicine composition
group
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杨进科
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
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    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/68—Plantaginaceae (Plantain Family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena

Abstract

The present invention disclose a kind of have pain and the Chinese medicine composition of bone strengthening.Said composition is made up of 33 taste crude drug such as Radix Notoginseng, Rhizoma Bergeniae scopulosae, Cortex Ampelopsis Aconitifoliae Radicis, Scorpio, Squama Manis, acer yangjuechi, Rhizoma Panacis Japonici, Daphne giraldii Nitsche, Radix Lamiophlomidis Rotatae, Semen Strychni.Chinese medicine composition of the present invention adds customary adjuvant according to common process and makes emplastrum, ointment, spray, liniment or the tincture of clinical acceptance.Pharmaceutical composition of the present invention is that pure Chinese medicine is made, and has stronger analgesic activity, and analgesic effect is notable, and no dependence has no side effect.

Description

A kind of Chinese medicine composition with analgesic activity
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of Chinese medicine composition with analgesic activity.
Background technology
Pain is a kind of protection mechanism of body self, and it both can make body avoid some may damage the danger of body Stimulate, it is also possible to be a kind of alarm of body abnormality.But meanwhile, pain is likely to damage body, it Existence can cause the change of psychology and emotion-directed behavior, becomes a kind of pernicious stimulation, causes autonomic nervous system and hormonal system The change of function, thus the rising of increased heart rate, blood pressure, perspiration, hypermyotonia, blood system change, endocrine occur and exempts from The phenomenons such as epidemic disease system disorders, have had a strong impact on the life of people.At present, clinical conventional analgesic is broadly divided into three classes: non-steroid Body anti-inflammation analgesia medicine, central analgesics and narcosis analgesic.NSAID (non-steroidal anti-inflammatory drug) is a class medicine of wide clinical application, But gastrointestinal tract and cardiovascular adverse effects limit its application；Central analgesics and narcosis analgesic effect are efficient, are used for Moderate and severe pain, long-term taking may result in the most serious untoward reaction, and produces toleration；Except above-mentioned three class analgesic Outward, the most some other analgesic, but analgesic activity is unsatisfactory.Therefore, it is badly in need of developing a kind of new potent, safe, resistance to Good, the medicine of no dependence by property.
Summary of the invention
Present invention aim at providing a kind of Chinese medicine composition with analgesic activity.
The present invention is achieved through the following technical solutions:
The crude drug of Chinese medicine composition of the present invention consists of:
The crude drug composition of Chinese medicine composition of the present invention is preferably:
The crude drug composition of Chinese medicine composition of the present invention is preferably:
The crude drug composition of Chinese medicine composition of the present invention is preferably:
Chinese medicine composition of the present invention according to common process add customary adjuvant make the capsule of clinical acceptance, tablet, Granule, pill, oral liquid, emplastrum, ointment, spray, liniment or tincture.
Pharmaceutical composition of the present invention is that pure Chinese medicine is made, and has stronger analgesic activity, and analgesic effect is notable, without relying on Property, have no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
Experimental example: pharmacologically active is tested
1, hot plate method
1.1 experimental technique
Water bath topped up with water, makes the water surface contact hot plate, and regulating thermostatic device, water temperature controls at 55 ± 5 DEG C, room temperature 20 ± 1 DEG C hot plate need to preheat 10min.Taking the Kunming mouse 60 of body weight 18～22g, female, each one is merely placed on hot plate, mice Up to occur licking metapedes or jumping out of the hot plate required time (second) pain threshold as this Mus from being placed on hot plate.All lick foot the time little In 5 seconds or give it up more than 30 seconds persons.Qualified group is randomly divided into 6 groups of (excipient group, positive controls, Daphne giraldii Nitsche Plaster group, the embodiment of the present invention 1,2,3 (3 groups), often group 10.Within 24 hours, lose hair or feathers in mouse web portion same area before the test, Depilation area about 2.0 × 2.0cm2.Basic Pain Threshold value before it is administered is measured after 24h.
Respectively being organized by reagent and be affixed on mouse web portion depilation district respectively, it is 1.0 × 1.0cm that patch powder amasss2, excipient group patch is identical Area blank is pasted, Zushima gaoyao group, positive controls patch QIZHENG XIAOTONG TIE, the embodiment of the present invention 1 group, the embodiment of the present invention 2 Group, the embodiment of the present invention 3 groups are administered area (120mg kg identical with administration group-1).Fixed with medical proof fabric, outside every day Patch is administered once, successive administration three days, and 1,2,4,8h after last is administered measure its response time respectively, such as 60 seconds still without anti- Should, mice is taken out, in order to avoid scalding, its pain threshold calculated with 60 seconds.
1.2 experimental result
With threshold of pain raising percentage rate as vertical coordinate, after administration, different time is that abscissa is mapped to show dose-effect, time-effect relationship.
Simplify random chance method and calculate active drug raising ED in the threshold of pain in a specified time50And 95% credible limit, knot Close statistical test, respectively organize action intensity.The method of inspection is t-inspection.Specific experiment result is as shown in table 1.
The comparison of hot plate method in mice pain experiments pain threshold respectively organized by table 1
Compare with excipient groupΔP ＜ 0.05,ΔΔP ＜ 0.01
Embodiment of the present invention 1-3 group compares pain threshold with very just disappearing group and Daphne giraldii Nitsche group bitterly, and there were significant differences.
2. acetic acid writhing test
2.1 experimental technique
Take the Kunming mouse 60 of body weight 18～22g, male and female half and half, be randomly divided into 6 groups (blank group, positive controls, Zushima gaoyao group, each 10 of embodiment of the present invention 1-3 (three groups).Within 24 hours, take off in mouse web portion same area before the test Hair, lose hair or feathers area about 2.0 × 2.0cm2.Test medicine is respectively organized and is affixed on mouse web portion depilation district respectively, blank patch group patch identical faces Long-pending blank patch, positive controls patch QIZHENG XIAOTONG TIE, often group is administered area and is respectively 120mg kg-1.Every day, external application was administered one Secondary, successive administration three days, after last is administered 6h, lumbar injection 0.6% aqueous acetic acid (10mL/kg), then that mice is independent Put in transparent plastics cage, count its writhing number of times in 20min.
By following equation calculating suppression ratio:
Suppression ratio=(blank group average time-treatment group average time)/blank group average time × 100%.
2.2 experimental result
Each for administration treated animal writhing average is compared with matched group writhing average, carries out statistics t-inspection.Specifically Experimental result is as shown in table 2:
The compound percutaneous gel of table 2 is on the impact (n=10) of writhing number of times after mouse peritoneal injection acetic acid
Note: compare with blank patch groupΔP ＜ 0.05,ΔΔP ＜ 0.01
Embodiment of the present invention 1-3 group compares analgesia percentage rate with very just disappearing group and Daphne giraldii Nitsche group bitterly, and there were significant differences.
Following embodiment all can realize the effect of above-mentioned experimental example.
Detailed description of the invention
Embodiment 1 emplastrum
Said medicine is added customary adjuvant according to common process and makes emplastrum, 1 day/patch.
Embodiment 2 emplastrum
Said medicine is added customary adjuvant according to common process and makes emplastrum, 1 day/patch.
Embodiment 3 emplastrum
Said medicine is added customary adjuvant according to common process and makes emplastrum, 1 day/patch.
Embodiment 4 capsule
Said medicine adds customary adjuvant according to common process and makes capsule.Within every 6 hours, can take once, each two Grain.
Embodiment 5 pill
Said medicine adds customary adjuvant according to common process and makes pill.Within every 6 hours, can take once, each 1 ball.
Embodiment 6 tablet
Said medicine is added customary adjuvant according to common process and makes tablet, within every 6 hours, can take once, each 2.
Embodiment 4 ointment
Said medicine adds customary adjuvant according to common process and makes ointment.

Claims (6)

1. a Chinese medicine composition with analgesic activity, it is characterised in that the crude drug of said composition consists of:
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the crude drug of said composition consists of:
3. Chinese medicine composition as claimed in claim 1, it is characterised in that the crude drug of said composition consists of:
4. Chinese medicine composition as claimed in claim 1, it is characterised in that the crude drug of said composition consists of:
5. the Chinese medicine composition as described in one of claim 1-4, it is characterised in that said composition often adds according to common process Emplastrum, ointment, spray, liniment or the tincture of clinical acceptance made by rule adjuvant.
6. the Chinese medicine composition as described in one of claim 1-4 has the application in the medicine of analgesic in preparation treatment.
CN201610522223.3A 2016-06-28 2016-06-28 A kind of Chinese medicine composition with analgesic activity Pending CN106110243A (en)

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Application Number Priority Date Filing Date Title
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698829A (en) * 2005-06-15 2005-11-23 李景辉 Ointment for trauma and injury and its preparation method
CN105213901A (en) * 2015-10-20 2016-01-06 康明 A kind of antigout drug compositions, its application and preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1698829A (en) * 2005-06-15 2005-11-23 李景辉 Ointment for trauma and injury and its preparation method
CN105213901A (en) * 2015-10-20 2016-01-06 康明 A kind of antigout drug compositions, its application and preparation method

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Application publication date: 20161116