CN106109608A - A kind of Chinese medicine composition treating urticaria and preparation thereof and application - Google Patents
A kind of Chinese medicine composition treating urticaria and preparation thereof and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition treating urticaria and preparation thereof and application, described Chinese medicine composition includes the crude drug of following weight portion: Corium Erinacei Seu Hemiechianus 50～150 parts, Herba Schizonepetae 50～150 parts, Radix Saposhnikoviae 50～150 parts, Radix Paeoniae Rubra 100～200 parts, Periostracum Cicadae 30～80 parts, the Fructus Kochiae 50～150 parts, Fructus Cnidii 50～150 parts.In prescription of the present invention, Corium Erinacei Seu Hemiechianus removing heat from blood, removing toxic substances, pain relieving, Herba Schizonepetae induce sweat scattered wind, rash, disappear skin ulcer, Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, Radix Paeoniae Rubra clearing away heat and cooling blood, pain relieving, Periostracum Cicadae dispelling wind and heat pathogens, rash, Fructus Kochiae eliminating damp-heat, antipruritic, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, the mutual synergism of each component, dispelling wind pathogens, removing dampness to relieve itching, nourishes blood and seeks, skin-active granulation promoting, to treating acute, the excellent curative of chronic urticaria, cure rate is high, and safety coefficient is high, deeply liked by patient.It addition, according to clinical verification, Chinese medicine composition of the present invention applies also for treating contact dermatitis, autosensitization dermatitis.
Description
Technical field
The present invention relates to tcm field, particularly relate to a kind of Chinese medicine composition treating urticaria and preparation thereof and answer
With.
Background technology
Urticaria is commonly called as welt, is a kind of common dermatosis.Mucocutaneous blood vessel is caused to occur temporarily by various factors
Property inflammatory hyperemia is oozed out with big quantity of fluid.Cause the infringement of local edema.It occurs rapidly and disappears, has play to itch.Can have and send out
Burn, suffer from abdominal pain, suffer from diarrhoea or other General Symptomies.Can be caused by many factors, its pathomechanism illustrates the most completely.Modern Western medicine
Primary disease be there is no specific short.To frequent recurrent exerbation person, it is difficult to radical cure, and application Western medicine also can produce some side reactions.Therefore
It is badly in need of a kind of urticaria for the treatment of and there is the Chinese medicine composition of significant curative effect.
Summary of the invention
In view of this, the invention provides a kind of Chinese medicine composition treating urticaria and preparation thereof and application, described in
Drug composition has significant curative effect to treatment urticaria, and cure rate is high, and safe and free of toxic and side effects.
The technological means that the present invention uses is as follows: a kind of Chinese medicine composition treating urticaria, including following weight portion
Crude drug: Corium Erinacei Seu Hemiechianus 50～150 parts, Herba Schizonepetae 50～150 parts, Radix Saposhnikoviae 50～150 parts, Radix Paeoniae Rubra 100～200 parts, Periostracum Cicadae 30～80
Part, the Fructus Kochiae 50～150 parts, Fructus Cnidii 50～150 parts.
Preferably, the Chinese medicine composition of described treatment urticaria, including the crude drug of following weight portion: Corium Erinacei Seu Hemiechianus 80～
120 parts, Herba Schizonepetae 80～120 parts, Radix Saposhnikoviae 80～120 parts, Radix Paeoniae Rubra 120～180 parts, Periostracum Cicadae 40～60 parts, the Fructus Kochiae 80～120
Part, Fructus Cnidii 80～120 parts.
Preferably, the Chinese medicine composition of described treatment urticaria, including the crude drug of following weight portion: Corium Erinacei Seu Hemiechianus 100 parts,
Herba Schizonepetae 100 parts, Radix Saposhnikoviae 100 parts, Radix Paeoniae Rubra 150 parts, Periostracum Cicadae 50 parts, the Fructus Kochiae 100 parts, Fructus Cnidii 100 parts.
Present invention also offers a kind of Chinese medicinal composition preparation treating urticaria, comprise any one institute that the present invention provides
The Chinese medicine composition of the treatment urticaria stated, the Chinese medicinal composition preparation of described treatment urticaria be decoction, granule, pill or
The one of capsule.
Present invention also offers the Chinese medicine composition of described treatment urticaria preparation treatment urticaria, contact dermatitis,
Application in the medicine of autosensitization dermatitis.
Beneficial effect: a kind of Chinese medicine composition treating urticaria provided by the present invention, Corium Erinacei Seu Hemiechianus removing heat from blood, solution in side
Poison, pain relieving, Herba Schizonepetae induce sweat scattered wind, rash, disappear skin ulcer, Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, Radix Paeoniae Rubra clearing away heat and cooling blood, pain relieving, Periostracum Cicadae dredge
Dissipating wind heat, rash, Fructus Kochiae eliminating damp-heat, antipruritic, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, the mutual synergism of each component, dredges
Dissipate ailment said due to cold or exposure, removing dampness to relieve itching, nourish blood and seek, skin-active granulation promoting, to treating acute, the excellent curative of chronic urticaria, cure rate is high, and
Safety coefficient is high, is deeply liked by patient.It addition, according to clinical verification, Chinese medicine composition of the present invention applies also for treatment and connects
Touch property dermatitis, autosensitization dermatitis.
Detailed description of the invention
Introduce the nature and flavor of primary raw material medicine based on the following " Chinese Pharmacopoeia ", " Chinese medicine voluminous dictionary " and " China's draft ", return
The basic conditions such as warp, function and application.
Corium Erinacei Seu Hemiechianus: bitter, sweet, flat.Clots absorbing pain relieving, hemostasis, controlling nocturnal emission with astringent drugs.For gastralgia, metrorrhagia, have blood in stool, hemorrhoid, lose
Essence, the enuresis.
Herba Schizonepetae: pungent, tepor.Return lung, Liver Channel.Induce sweat scattered wind, rash, and disappear skin ulcer.For catching a cold, headache, measles, rubella, skin ulcer
Infections from the beginning of.
Radix Saposhnikoviae: pungent, sweet, tepor.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.For headache due to common cold, wind
Pain of dampness syndrome, rubella pruritus, tetanus.
Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Nutrient blood is entered for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis,
Conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, injury from falling down, carbuncle skin infection.
Periostracum Cicadae: sweet, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, sore-throat relieving, rash, improving acuity of vision and removing nebula, spasmolytic.For anemopyretic cold, pharynx
Hoarseness bitterly, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
The Fructus Kochiae: pungent, bitter, cold.Return kidney, bladder warp.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia,
Rubella, eczema, skin pruritus.
Fructus Cnidii: pungent, bitter, temperature；Slightly poisonous.Return kidney channel.Dampness is dispeled the wind, killing parasites for relieving itching, warming the kidney to invigorate YANG.For pudendal pruritus band
Under, eczema pruritus, arthralgia chiefly caused by damp pathogen lumbago, impotence due to deficiency of the kidney, cold womb is infertile.
Being described the specific embodiment of the present invention below, illustrated embodiment is served only for explaining the present invention, is not intended to
Limit the scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 5g, Herba Schizonepetae 5g, Radix Saposhnikoviae 5g, Radix Paeoniae Rubra 10g, Periostracum Cicadae 3g, Fructus Kochiae 5g, Fructus Cnidii 5g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 2
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 15g, Herba Schizonepetae 15g, Radix Saposhnikoviae 15g, Radix Paeoniae Rubra 20g, Periostracum Cicadae 8g, Fructus Kochiae 15g, Fructus Cnidii 15g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 3
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 8g, Herba Schizonepetae 8g, Radix Saposhnikoviae 8g, Radix Paeoniae Rubra 12g, Periostracum Cicadae 4g, Fructus Kochiae 8g, Fructus Cnidii 8g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 4
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 12g, Herba Schizonepetae 12g, Radix Saposhnikoviae 12g, Radix Paeoniae Rubra 18g, Periostracum Cicadae 6g, Fructus Kochiae 12g, Fructus Cnidii 12g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 5
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 10g, Herba Schizonepetae 10g, Radix Saposhnikoviae 10g, Radix Paeoniae Rubra 10g, Periostracum Cicadae 3g, Fructus Kochiae 10g, Fructus Cnidii 5g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 6
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 10g, Herba Schizonepetae 10g, Radix Saposhnikoviae 10g, Radix Paeoniae Rubra 20g, Periostracum Cicadae 8g, Fructus Kochiae 10g, Fructus Cnidii 15g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
Embodiment 7
A kind of Chinese medicine composition treating urticaria, including the crude drug of following weight:
Corium Erinacei Seu Hemiechianus 10g, Herba Schizonepetae 10g, Radix Saposhnikoviae 10g, Radix Paeoniae Rubra 15g, Periostracum Cicadae 5g, Fructus Kochiae 10g, Fructus Cnidii 10g.
Above-mentioned raw materials medicine soak by water according to a conventional method.
A kind of traditional Chinese medicine composition for treating urticaria treating urticaria of the present invention has significant effect, in order to verify it
Beneficial effect, tests each embodiment of a kind of Chinese medicine composition treating urticaria of the present invention, test method and
Result is as follows:
One, clinical data
1, basic document: collect urticaria patient 630 example altogether, including acute urticaria and chronic urticaria case；Acute
Urticaria test group: test group 1～test group 7, often organizes 40 examples；Chronic urticaria test group: test group 8～test group 14, often
Organize 50 examples.
(1) acute urticaria test group
Test group 1: this organizes 40 examples, age 18～63 years old, 35.3 years old mean age.
Test group 2: this organizes 40 examples, age 18～63 years old, 34.8 years old mean age.
Test group 3: this organizes 40 examples, age 17～62 years old, 34.2 years old mean age.
Test group 4: this organizes 40 examples, age 19～63 years old, 35.6 years old mean age.
Test group 5: this organizes 40 examples, age 17～63 years old, 35.3 years old mean age.
Test group 6: this organizes 40 examples, age 16～64 years old, 35.2 years old mean age.
Test group 7: this organizes 40 examples, age 18～63 years old, 35.4 years old mean age.
(2) chronic urticaria test group
Test group 8: this organizes 50 examples, age 16～63 years old, 36.2 years old mean age.
Test group 9: this organizes 50 examples, age 18～64 years old, 37.3 years old mean age.
Test group 10: this organizes 50 examples, age 18～62 years old, 35.8 years old mean age.
Test group 11: this organizes 50 examples, age 17～65 years old, 36.6 years old mean age.
Test group 12: this organizes 50 examples, age 18～63 years old, 36.5 years old mean age.
Test group 13: this organizes 50 examples, age 18～64 years old, 35.7 years old mean age.
Test group 14: this organizes 50 examples, age 16～63 years old, 36.4 years old mean age.
2, clinical manifestation: urticaria includes acute urticaria and chronic urticaria；The whole course of disease of acute urticaria is shorter than one
Individual month, typically can find the cause of disease, such as infection, medicine, food, contact allergy etc.；The chronic urticaria course of disease was more than one month, repeatedly
Outbreak, it is difficult to find the cause of disease.
Acute urticaria: the welt not waited sized by (1) erythra, color is scarlet, it is possible to for pale asphyxia, isolates and is dispersed in or merges
In flakes, in a few hours, welt alleviates, and becomes erythema and the mistake that fades.But constantly there is new welt to occur.(2) person of being in a bad way can have
, there is anaphylactic shock sample symptom in the symptoms, even blood pressure drops such as irritated, nervous, Nausea and vomiting；Have can be because involving gastrointestinal
Mucous membrane and stomachache, nausea,vomiting,diarrhea occur, have very like acute abdomen, have has eating difficulties because of esophagus edema；Involve
During larynx mucosa, when may occur in which, may occur in which laryngeal edema, breathe suffering, even suffocate.If any systemic toxicity profiles such as high heat, shiver with colds
Symptom, should determine whether severe infections.
Chronic urticaria: General Symptoms is the lightest, few time many during welt, happens over and over again, and the course of disease is more than one month.
3, clinical criteria: 1. erythra plays delitescence suddenly, for redness different, that differ in size or pale asphyxia welt.
Dermatograph test is positive.2. acute pruritus, severe one can be with General Symptomies such as heatings.3. part case can have abdominal pain diarrhea,
Severe patient can have dyspnea, even causes and suffocates.4. acute onset, the course of disease does not exceed 1 month person and claims acute urticaria, the course of disease to hold
Continuous more than 1 month, the most referred to as chronic urticaria.
Two, Therapeutic Method and the course for the treatment of
(1) acute urticaria test group
Test group 1: a kind of Chinese medicine composition (embodiment 1) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 2: a kind of Chinese medicine composition (embodiment 2) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 3: a kind of Chinese medicine composition (embodiment 3) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 4: a kind of Chinese medicine composition (embodiment 4) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 5: a kind of Chinese medicine composition (embodiment 5) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 6: a kind of Chinese medicine composition (embodiment 6) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
Test group 7: a kind of Chinese medicine composition (embodiment 7) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took a course for the treatment of.
(2) chronic urticaria test group
Test group 8: a kind of Chinese medicine composition (embodiment 1) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 9: a kind of Chinese medicine composition (embodiment 2) treating urticaria of the present invention, day 1 dose, decocting divides 2 temperature
Taking, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 10: a kind of Chinese medicine composition (embodiment 3) treating urticaria of the present invention, day 1 dose, decocting divides 2 times
Decoction being taken warmly use, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 11: a kind of Chinese medicine composition (embodiment 4) treating urticaria of the present invention, day 1 dose, decocting divides 2 times
Decoction being taken warmly use, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 12: a kind of Chinese medicine composition (embodiment 5) treating urticaria of the present invention, day 1 dose, decocting divides 2 times
Decoction being taken warmly use, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 13: a kind of Chinese medicine composition (embodiment 6) treating urticaria of the present invention, day 1 dose, decocting divides 2 times
Decoction being taken warmly use, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Test group 14: a kind of Chinese medicine composition (embodiment 7) treating urticaria of the present invention, day 1 dose, decocting divides 2 times
Decoction being taken warmly use, 15 days was 1 course for the treatment of, took two courses for the treatment of.
Three, therapeutic outcome
Curative effect judging standard: recovery from illness: after treatment, erythra and pruritus are wholly absent, and drug withdrawal has no recurrence in more than 3 months.Good
Turn: the symptoms such as erythra disappears substantially, pruritus are improved, but still have 1～2 outbreak within 3 months, or still have outbreak, but outbreak
Degree and number of times significantly reduce.Invalid: sings and symptoms is all without substantially changing.Total effective=(recovery from illness+take a turn for the better), total effective rate
=(recovery from illness+take a turn for the better)/total number of cases.
1, the therapeutic effect of each acute urticaria test group is as shown in table 1 below:
2, the therapeutic effect of each chronic urticaria test group is as shown in table 2 below:
3, model case
1. patient Zhang, man 21 years old, conscious skin of back pruritus after private prosecution was moved before 2 days during patient assessment, without substantially burning
Burning and feel or pain, large stretch of red welt occur, gradually spread to double upper limb and breast buttocks after scratching at pruritus, scratchiness is more strengthened
Strong, examine as acute urticaria.Taking Drug therapy of the present invention after 3 days, welt disappears substantially, and scratchiness is obviously improved, and takes medicine again
Thing was fully recovered after 4 days, after follow up a case by regular visits to drug withdrawal over the past half year without recurrence.
2. patient king so-and-so, man 25 years old, private prosecution conscious whole skin scabies when working in workshop before 1 hour during patient assessment
Itch, large stretch of red welt occurs at pruritus after scratching, diffuse to all visible wind that gathers of face, cervical region, thorax abdomen, extremity and biped
Group's sample maculopapule, scratchiness is strong, examines as acute urticaria.After taking half course for the treatment of of Drug therapy of the present invention, welt disappears substantially
Losing, scratchiness is obviously improved, and takes again and fully recovers after half course for the treatment of, after follow up a case by regular visits to drug withdrawal 3 months over without recurring.
3. patient Chen, female 30 years old is during patient assessment after 1 day cause food seafood chaffy dish of private prosecution, conscious when this morning is got up
Skin of chest abdomen pruritus, there is large stretch of red welt in skin afterwards, and scratchiness is strong, examines as acute urticaria.Take the present invention
After half course for the treatment of of Drug therapy, welt disappears substantially, and scratchiness is obviously improved, and fully recovers after taking again half course for the treatment of, after follow up a case by regular visits to drug withdrawal
Over the past half year without recurrence.
4. patient river, man 30 years old, during patient assessment, private prosecution takes on back pruritus companion's red grouper pimple 3 years repeatedly, this because of
Causing after drinking with friend's party, conscious shoulder skin of back pruritus, after scratching, there is large stretch of red welt in skin, and scratchiness is strong
Strong, examine as chronic urticaria.After taking 1 course for the treatment of of Drug therapy of the present invention, welt disappears substantially, and scratchiness is obviously improved, again
Take and fully recover after 1 course for the treatment of, after follow up a case by regular visits to drug withdrawal over the past half year without recurring.
5. patient Cai so-and-so, female 52 years old, during patient assessment, private prosecution occurred that whole body pruritus accompanied welt in recent years, time disappear when rising,
Many Claritin (the most not quite clear) was administered orally, and after equal drug withdrawal, symptom is repeatedly, and cause on the 2nd is in conscious back after cleaning
Skin pruritus, occurs large stretch of red welt subsequently, and scratchiness is strong, examines as chronic urticaria.Take Drug therapy of the present invention half
After the individual course for the treatment of, welt disappears substantially, and scratchiness is obviously improved, and fully recovers after taking again half course for the treatment of, continues to take 1 course for the treatment of afterwards and consolidates
Gu therapeutic effect, after follow up a case by regular visits to drug withdrawal over 1 year without recurrence.
6. patient Zhang, female 29 years old, because occurring after perspiration wind-engaging that skin pruritus accompanies welt during private prosecution 18 years old during patient assessment,
Just start to take Claritin (the most not quite clear) the best, after increase the weight of year by year, annual spring fall ill once.Showed effect frequency in recent years
Numerous, get angry whenever, tired, Changes in weather time all can fall ill, after to bad during hospitalize also fashion, examine as chronic urticaria.Clothes
With after 1 course for the treatment of of Drug therapy of the present invention, welt disappears substantially, and scratchiness is obviously improved, and fully recovers after taking again 1 course for the treatment of, after with
Visit drug withdrawal over the past half year without recurrence.
Four, untoward reaction is observed
In Ureteral Calculus case, find no untoward reaction patient, show that a kind of of the present invention treats in urticaria
Drug composition is safe and reliable.
Shown by above-mentioned clinical trial, a kind of Chinese medicine composition treating urticaria of the present invention to treatment acute,
Chronic urticaria is respectively provided with good curative effect, wherein, is up to 90% for the cure rate of acute urticaria patient treatment, the most effective
Rate is up to 100%；Be up to 68% for the cure rate of chronic urticaria patients treatment, total effective rate is up to 92%.Wherein, acute
Urticaria test group 3～4 is better than the therapeutic effect of acute urticaria test group 1～2, and chronic urticaria test group 10～11 ratio is slowly
Property urticaria test group 8～9 therapeutic effect good, show embodiment 3～4 compare embodiment 1～2 to treat nettle acute, chronic
The effect of measles is more preferable, and embodiment 3～4 compares each component synergism of embodiment 1～2 more preferably；And acute urticaria test group 7
More preferable than the therapeutic effect of acute urticaria test group 3～4, chronic urticaria test group 14 than chronic urticaria test group 10～
The therapeutic effect of 11 is good, can draw, compares embodiment 1～4, and embodiment 7 is optimal to treating effect acute, chronic urticaria
, the weight ratio of each component of embodiment 7 is most preferred so that each component synergism is optimal.It addition, acute urticaria test
Group 7 is better than the therapeutic effect of acute urticaria test group 5～6, chronic urticaria test group 14～ratio chronic urticaria test group
The therapeutic effect of 12～13 is good, shows that embodiment 7 compares each component synergism of embodiment 5～6 more preferably, show component Radix Paeoniae Rubra,
Periostracum Cicadae, Fructus Cnidii have large effect to curative effect.Acute urticaria test group 5 is than the therapeutic effect of acute urticaria test group 1
Good, chronic urticaria test group 12 is better than the therapeutic effect of chronic urticaria test group 8, i.e. embodiment 5 compares the treatment of embodiment 1
Effect is more preferably；Acute urticaria test group 6 is better than the therapeutic effect of acute urticaria test group 2, and chronic urticaria test group 13 compares
The therapeutic effect of chronic urticaria test group 9 is good, i.e. embodiment 6 compares the curative effect of embodiment 2 more preferably, show component Corium Erinacei Seu Hemiechianus,
Herba Schizonepetae, Radix Saposhnikoviae, the Fructus Kochiae have large effect to curative effect.To sum up, a kind of Chinese medicine treating urticaria that the present invention provides is described
Compositions, the mutual synergism of each component, chronic urticaria acute to treatment has significant curative effect, and safety is high, nontoxic pair
Effect.
In a further embodiment, a kind of Chinese medicine composition treating urticaria of the present invention is prepared by a conventional method into
Decoction, granule, pill or capsule, treat curative effect acute, that chronic urticaria is respectively provided with good effect, especially granule
More preferably.
Additionally inventor also by clinical case find Chinese medicine composition of the present invention to treatment contact dermatitis, from
Body sensitivity dermatitis also has good effect.Administrated method, the course for the treatment of, treatment standard and clinical treatment situation are as follows:
Collecting 60 example contact dermatitis patients altogether, administrated method and the course for the treatment of be: Chinese medicine composition of the present invention (is implemented
Example 7), day 1 dose, decocting divides 2 decoction being taken warmly use, and 15 days was 1 course for the treatment of, took a course for the treatment of.Treatment standard: recovery from illness: local skin tide
Red, pimple all disappears, and the no positive sign of whole body can be looked into.Take a turn for the better: local skin flushing, pimple substantially alleviate, but still have local
Pruritus phenomenon.Invalid: symptom is without improving.The most effectively=(recovery from illness+take a turn for the better), total effective rate=(recovery from illness+improvement)/total number of cases.
Case number of cases for contact dermatitis patient outcomes is as shown in table 3 below:
Case percent for contact dermatitis therapeutic effect is as shown in table 4 below:
| Case type | Recovery from illness (%) | Take a turn for the better (%) | Invalid (%) | Total effective (%) |
| Contact dermatitis | 65 | 27 | 8 | 92 |
Contact dermatitis model case:
1. patient Chen, man 52 years old, after contacting organophosphorus pesticide during work in the wild before private prosecution first quarter moon during patient assessment
Start that whole skin pruritus occurs night, in paroxysmal severe pain, with the both hands back of the body, forearm, cervical region more so, simultaneously with erythra, weary
Power, symptom increases the weight of daytime, and night alleviates, and examines as contact dermatitis.After taking half course for the treatment of of Drug therapy of the present invention, erythra is basic
Disappearing, scratchiness is obviously improved, and takes again and fully recovers after half course for the treatment of, after follow up a case by regular visits to drug withdrawal 3 months over without recurring.
2. Guo patient so-and-so, female 23 years old, after during patient assessment, private prosecution uses a cleansing milk to wash one's face for one week, self-induction face pruritus
Discomfort, two buccals and forehead occur that red rash, period took Claritin (the most not quite clear) poor effect subsequently, examine into
Contact dermatitis.Taking Drug therapy of the present invention after 3 days, erythra disappears substantially, and scratchiness is obviously improved, and fully recovers after taking again 4 days,
Continue the most again to take half course for the treatment of and consolidate curative effect, after follow up a case by regular visits to drug withdrawal over 3 months without recurrence.
3. Dong patient, man 55 years old, during patient assessment, private prosecution was arrived pharmacy voluntarily because of ocular pruritis before 1 day and is bought eye drop, modern
Morning day finds that banding erythema occur in nose both sides and two palpebra inferior skins when rising, and scratchiness is strong, examines as contact dermatitis.Take this
After half course for the treatment of of invention Drug therapy, erythra disappears substantially, and scratchiness is obviously improved, and takes again the half recovery from illness course for the treatment of, after follow up a case by regular visits to stop
Medicine is over the past half year without recurrence.
Being shown by clinical trial, the Chinese medicine composition that the present invention provides, the total effective rate for the treatment of contact dermatitis reaches
92%, clinical therapeutic efficacy is good, it is seen that the Chinese medicine composition that the present invention provides has significant curative effect to treatment contact dermatitis.
Collecting 60 example autosensitization dermatitis patients altogether, administrated method and the course for the treatment of be: Chinese medicine composition of the present invention
(embodiment 7), day 1 dose, decocting divides 2 decoction being taken warmly use, and 15 days was 1 course for the treatment of, took a course for the treatment of.Treatment standard: recovery from illness: whole body is general
The erythra sent out all disappears.Take a turn for the better: erythra significantly reduces, but still have local pruritus phenomenon.Invalid: symptom is without improving.Total effective
=(recovery from illness+take a turn for the better), total effective rate=(recovery from illness+take a turn for the better)/total number of cases * 100%.
Case number of cases for autosensitization dermatitis patient outcomes is as shown in table 5 below:
Case percent for autosensitization dermatitis patient outcomes is as shown in table 6 below:
| Case type | Recovery from illness (%) | Take a turn for the better (%) | Invalid (%) | Total effective (%) |
| Autosensitization dermatitis | 62 | 28 | 10 | 90 |
Autosensitization dermatitis model case:
1. patient Huang, female 27 years old, scald because being spattered to the back of the hand by deep fat during cooking before private prosecution 1 day during patient assessment, due to
Scald the not serious moist expose burn ointment of application voluntarily and smear affected part, find, around wound surface, pimple occurs after getting up today, i.e. disable burning
Hinder cream, but symptom constantly increases the weight of, acute pruritus, examine as autosensitization dermatitis.After taking half course for the treatment of of Drug therapy of the present invention,
Pimple disappears substantially, and scratchiness is obviously improved, and takes again and fully recovers after half course for the treatment of, after follow up a case by regular visits to drug withdrawal 3 months over without recurring.
2. patient Lee, female 33 years old, during patient assessment, 1 day cause of private prosecution is autoscootered accidentally to left side medial leg skin
Scalding, local skin diabrosis companion ooze out, and voluntarily after 3, Amoxicillin Capsules powder of the outer painting in local, wound local occurs red soon
Swollen increase the weight of, the red pimple companion's acute pruritus that gathers, examine as autosensitization dermatitis.Take half course for the treatment of of Drug therapy of the present invention
After, redness disappears, and pimple disappears substantially, and scratchiness is obviously improved, and takes again and fully recovers after half course for the treatment of, after follow up a case by regular visits to drug withdrawal over the past half year without
Recurrence.
3. patient Zeng, man 24 years old, after during patient assessment, private prosecution cause tourism in 2 days is returned, double forearm Exposure to Sunlight positions occur
Red papules, gradually diffuses to upper limb, back, buttocks, femoribus internus, and pruritus is strong, and personal PIYANPING smears improvement, after the most anti-
Multiple, examine as autosensitization dermatitis.After taking half course for the treatment of of Drug therapy of the present invention, pimple disappears substantially, and scratchiness substantially changes
Kind, fully recover after taking again half course for the treatment of, after follow up a case by regular visits to drug withdrawal over the past half year without recurring.
Shown by clinical trial, the Chinese medicine composition that the present invention provides, the total effective rate for the treatment of autosensitization dermatitis
Reaching 90%, therapeutic effect is notable, shows that the Chinese medicine composition that the present invention provides is also applied for treating autosensitization dermatitis.
In sum, a kind of Chinese medicine composition treating urticaria provided by the present invention, Corium Erinacei Seu Hemiechianus removing heat from blood, detoxifies, only
Bitterly, Herba Schizonepetae induce sweat scattered wind, rash, disappear skin ulcer, Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, Radix Paeoniae Rubra clearing away heat and cooling blood, pain relieving, Periostracum Cicadae evacuate wind
Heat, rash, Fructus Kochiae eliminating damp-heat, antipruritic, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, the mutual synergism of each component, evacuates wind
Heresy, removing dampness to relieve itching, nourish blood and seek, skin-active granulation promoting, to treating acute, the excellent curative of chronic urticaria, cure rate is high, and safety
Coefficient is high, is deeply liked by patient.It addition, according to clinical verification, Chinese medicine composition of the present invention applies also for treating contact
Dermatitis, autosensitization dermatitis.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement etc. done, within should be included in the scope of protection of the invention.
Claims (6)
1. the Chinese medicine composition treating urticaria, it is characterised in that include the crude drug of following weight portion: Corium Erinacei Seu Hemiechianus 50～
150 parts, Herba Schizonepetae 50～150 parts, Radix Saposhnikoviae 50～150 parts, Radix Paeoniae Rubra 100～200 parts, Periostracum Cicadae 30～80 parts, the Fructus Kochiae 50～150
Part, Fructus Cnidii 50～150 parts.
A kind of Chinese medicine composition treating urticaria the most according to claim 1, it is characterised in that include following weight portion
Crude drug: Corium Erinacei Seu Hemiechianus 80～120 parts, Herba Schizonepetae 80～120 parts, Radix Saposhnikoviae 80～120 parts, Radix Paeoniae Rubra 120～180 parts, Periostracum Cicadae 40～
60 parts, the Fructus Kochiae 80～120 parts, Fructus Cnidii 80～120 parts.
A kind of Chinese medicine composition treating urticaria the most according to claim 1, it is characterised in that include following weight portion
Crude drug: Corium Erinacei Seu Hemiechianus 100 parts, Herba Schizonepetae 100 parts, Radix Saposhnikoviae 100 parts, Radix Paeoniae Rubra 150 parts, Periostracum Cicadae 50 parts, the Fructus Kochiae 100 parts, cnidium monnieri
Son 100 parts.
4. the Chinese medicinal composition preparation treating urticaria, it is characterised in that comprise described in any one of claims 1 to 3
The Chinese medicine composition for the treatment of urticaria, the Chinese medicinal composition preparation of described treatment urticaria is decoction, granule, pill or glue
The one of wafer.
5. the Chinese medicine composition of the treatment urticaria described in any one of claims 1 to 3 is in the medicine of preparation treatment urticaria
Application.
6. the Chinese medicine composition of the treatment urticaria described in any one of claims 1 to 3 preparation treatment contact dermatitis, self
Application in the medicine of sensitivity dermatitis.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596226A (en) * | 2017-10-11 | 2018-01-19 | 张雷 | A kind of Chinese medicine for treating autosensitization dermatitis |
| CN116514911A (en) * | 2023-04-20 | 2023-08-01 | 永创恒新生物医学科技(北京)有限公司 | Polypeptide and application thereof in preparation of medicines for treating chronic urticaria |
Citations (1)
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|---|---|---|---|---|
| CN104055900A (en) * | 2014-06-11 | 2014-09-24 | 张志红 | Traditional Chinese medicine composition for treating urticaria |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055900A (en) * | 2014-06-11 | 2014-09-24 | 张志红 | Traditional Chinese medicine composition for treating urticaria |
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| 刘瑶，等: "艾儒棣教授运用乌梢蛇配合刺猬皮治疗皮肤瘙痒症的经验", 《云南中医中药杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596226A (en) * | 2017-10-11 | 2018-01-19 | 张雷 | A kind of Chinese medicine for treating autosensitization dermatitis |
| CN116514911A (en) * | 2023-04-20 | 2023-08-01 | 永创恒新生物医学科技(北京)有限公司 | Polypeptide and application thereof in preparation of medicines for treating chronic urticaria |
| CN116514911B (en) * | 2023-04-20 | 2024-02-27 | 无锡观合医学检验所有限公司 | Polypeptide and application thereof in preparation of medicines for treating chronic urticaria |
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