CN106109519A - One panax species safely and efficiently and preparation technology thereof - Google Patents
One panax species safely and efficiently and preparation technology thereof Download PDFInfo
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- CN106109519A CN106109519A CN201610587404.4A CN201610587404A CN106109519A CN 106109519 A CN106109519 A CN 106109519A CN 201610587404 A CN201610587404 A CN 201610587404A CN 106109519 A CN106109519 A CN 106109519A
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- 241000208343 Panax Species 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000005516 engineering process Methods 0.000 title claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 20
- 244000005700 microbiome Species 0.000 claims abstract description 20
- 239000012567 medical material Substances 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 12
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 11
- 210000002615 epidermis Anatomy 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002604 ultrasonography Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- 241000180649 Panax notoginseng Species 0.000 claims description 23
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 23
- 241000208340 Araliaceae Species 0.000 claims description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 10
- 235000008434 ginseng Nutrition 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 5
- 239000001632 sodium acetate Substances 0.000 claims description 5
- 235000017281 sodium acetate Nutrition 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- -1 sodium bicarbonate, disodium hydrogen phosphate inorganic base Chemical class 0.000 claims description 4
- 235000011054 acetic acid Nutrition 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 3
- 229930182490 saponin Natural products 0.000 claims description 3
- 150000007949 saponins Chemical class 0.000 claims description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000342 sodium bisulfate Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000001540 sodium lactate Substances 0.000 claims description 2
- 229940005581 sodium lactate Drugs 0.000 claims description 2
- 235000011088 sodium lactate Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 229960002737 fructose Drugs 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract description 27
- 239000000575 pesticide Substances 0.000 abstract description 20
- 238000000034 method Methods 0.000 abstract description 17
- 239000000447 pesticide residue Substances 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 7
- 238000000746 purification Methods 0.000 abstract description 5
- 230000002378 acidificating effect Effects 0.000 abstract description 4
- 238000001308 synthesis method Methods 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 description 8
- 239000003905 agrochemical Substances 0.000 description 6
- 239000000428 dust Substances 0.000 description 6
- 229930182494 ginsenoside Natural products 0.000 description 5
- 235000002791 Panax Nutrition 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 229940089161 ginsenoside Drugs 0.000 description 3
- 230000037308 hair color Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000005807 Metalaxyl Substances 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229910052785 arsenic Inorganic materials 0.000 description 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 2
- 229960002643 clofenotane Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000007603 infrared drying Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 239000009759 San-Chi Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940078480 calcium levulinate Drugs 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- OORMXZNMRWBSTK-LGFJJATJSA-N dammarane Chemical compound C1CCC(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@H]([C@H](C)CCCC(C)C)[C@H]4CC[C@@H]3[C@]21C OORMXZNMRWBSTK-LGFJJATJSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- LKPLKUMXSAEKID-UHFFFAOYSA-N pentachloronitrobenzene Chemical compound [O-][N+](=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl LKPLKUMXSAEKID-UHFFFAOYSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses the preparation technology of a kind of panax species safely and efficiently, comprise the steps: (1), first medical material carried out that wind is washed, ultrasound wave is washed, ozone is washed, purify and remove the foreign material of epidermis, microorganism；(2), with the weak acid liquid eluting of the pH4 6 of 5 10 times, then the weak lye eluting of the pH7.5 9.5 with 5 10 times, finally cause pH7 8 with pure water eluting；(3), by (2) products obtained therefrom, it is drying to obtain panax species, the present invention is from the beginning of medical material selection, preliminary purification, enter back into Meta-Synthesis Method and the flow process innovative designs such as ultrasound wave, ozone clean purification, weak acid, weak base, the most scientific and reasonable go forward one by one, first remove basic residual pesticide and heavy metal by weak acid method, it is combined weak base method again and removes acidic residual pesticide and other heavy metals, the microorganism of product, pesticide residues and heavy-metal residual are less than statutory standards, it is ensured that product quality.
Description
Technical field
The present invention relates to a kind of panax species, be specifically related to a kind of panax species new product.
Background technology
Recording according to " the China Radix Notoginseng " that 1993 publish, panax species is mainly Radix Ginseng [P.ginseng
C.A.Meyer], Radix Panacis Quinquefolii [P.quinquefolius linn.], Radix Notoginseng [Panax notoginseng (Burk.)
F.H.Chen], their common trait be all contain dammarane type four-ring triterpenoid saponin, i.e. ginsenoside be its main pharmacodynamics live
Property composition.Radix Ginseng, strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.Containing more than 30 kinds of ginsenosides.Radix Notoginseng, dissipating blood stasis
Hemostasis, subduing swelling and relieving pain.Containing more than 50 kinds of ginsenosides.Radix Panacis Quinquefolii, tonification lung yin, promotes the production of body fluid, calms the nerves.Containing more than 10 kinds of Radix Ginseng soaps
Glycosides.
Being developed so far, panax species is widely used, but due to environmental pollution, planting process pesticide a large amount of
Use, cause Panax's medical material may be containing the arsenic exceeded standard, lead, hydrargyrum, heavy metal and Gamma Hexaochlorocyclohexane, clofenotane, the pentachloro-nitre such as cadmium
The organic agricultural chemicals such as base benzene and metalaxyl.The pesticide of these remainings to the personnel of life-time service by irreversible injury.
To this end, how to remove pesticide residues, become current urgent problems, solve residual pesticide problem select from soil,
Plant, safeguard, process, the links such as storage has all carried out some researchs, but has all failed conscientiously to solve problem.This problem is
Become the key issue of panax species development.
Summary of the invention
For solving the problems referred to above, the present invention proposes one panax species safely and efficiently and preparation technology thereof, uses
Wind is washed, ultrasound wave is washed, ozone is washed, weak acid, weak base combine removing microorganism, heavy metal, residual pesticide, and cleaning is used in integrated innovation
Purification, weak acid, the common perfect difficult problem solving biological medicine circle of weak base associating.
The present invention utilizes have multiple comprehensive functions such as pH dissolving, complexation, post separation to obtain safe Radix Ginseng compactly
Platymiscium medical material, can remove Panax's medical material brings containing the microorganism exceeded standard, arsenic, lead, hydrargyrum, the heavy metal and six or six such as cadmium
Six, the organic agricultural chemicals such as clofenotane, pentachloronitrobenzene and metalaxyl.
The principle of technical scheme:
1, first operation: purify medical material physico-chemical process and remove the dirt (including microorganism) of medical material epidermis as far as possible
And impurity, alleviate the pressure of subsequent treatment.
2, second operation work: weak acid liquid is cleaned and removed heavy metal and basic residual pesticide.
3, three process: weak lye removes acidic residual pesticide.
4, the complexing that in second and third procedure, organic acid has, can be in conjunction with removing heavy metal and containing metal
Pesticide residues part.
5, first use weak acid solution, then with weak caustic solution, allow for most heavy metal and be more easy in the basic conditions separate out sink
Form sediment at material surface, it more difficult to remove.And test proves that this flow process more preferably.
In a word, through above-mentioned integrated innovation Program Purge, product quality reaches food and medicine standard-required.
Standard foundation:
Main Basis CH.P 2015 and reference:
Element:
Organic agricultural chemicals:
The solution of the present invention is:
The preparation technology of a kind of panax species safely and efficiently of the present invention, comprises the steps:
(1), first by medical material carry out that wind is washed, ultrasound wave is washed, ozone is washed, purify and remove the foreign material of epidermis, microorganism；
(2), with the weak acid liquid eluting of the pH4-6 of 5-10 times, basic residual pesticide and heavy metal are removed, then with 5-10 times
The weak lye eluting of pH7.5-9.5, removes acidic residual pesticide and heavy metal, finally causes pH7-8 with pure water eluting；
(3), by (2) products obtained therefrom, it is drying to obtain panax species.
Described weak acid liquid be phosphoric acid, sodium dihydrogen phosphate, sodium bisulfate ore deposit acid and/or acetic acid, lactic acid, citric acid, malic acid,
Fumaric acid, LA organic acid.
Described weak lye is sodium carbonate, sodium bicarbonate, disodium hydrogen phosphate inorganic base and/or sodium acetate, sodium lactate, malic acid
Sodium, sodium citrate, calcium levulinate organic base.
The pH of described weak acid liquid is 4-6, and weak base pH is 7.5-9.5.
The panax species of above-mentioned preparation technology, the content of ginsenoside is 3%-12%
Described panax species is Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng.
Described panax species can be used for decoction pieces, extract, food, health food, oral formulations, formula.
Explanation of nouns:
The panax species that panax species the technical program refers to refers to Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng, and it is whole to comprise them
Operational all sites in strain plant, such as root, stem, leaf, flower, really.Can be dry product, can also be fresh goods.
Compared with prior art, the present invention, from the beginning of medical material selection, preliminary purification, enters back into ultrasound wave, smelly to the present invention
Meta-Synthesis Method and the flow process innovative designs such as oxygen cleaning, weak acid, weak base, the most scientific and reasonable go forward one by one, and first uses weak acid method
Remove basic residual pesticide and heavy metal, then be combined weak base method removing acidic residual pesticide and other heavy metals, micro-life of product
Thing, pesticide residues and heavy-metal residual are less than statutory standards, it is ensured that product quality.
Detailed description of the invention
Embodiment 1
The preparation of Radix Ginseng
Weigh the Radix Ginseng 2000g meeting 2015 editions Chinese Pharmacopoeias, pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the acetate solution eluting of the pH5.8 of 10 times, then the soda solution eluting of the pH9.5 with 10 times.Finally use
Pure water eluting causes pH7.8；
(3), the said goods infrared drying i.e. obtains panax species 1850g safely.
This product, the content of ginsenoside is 3.8%, and microorganism, heavy metal and residual pesticide are less than national standard/or not
Detection.
Embodiment 2
The preparation of Radix Panacis Quinquefolii
Weigh the Radix Panacis Quinquefolii 2000g meeting 2015 editions Chinese Pharmacopoeias, pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the citric acid solution eluting of the pH5.2 of 5 times, then the disodium hydrogen phosphate liquid eluting of the pH8.5 with 5 times.Finally
PH7.8 is caused with pure water eluting；
(3), lyophilization i.e. obtains Radix Panacis Quinquefolii 1928g safely.
This product, the content of Radix Panacis Quinquefolii saponin is 4.9%, microorganism, heavy metal and residual pesticide less than national standard/or
Do not detect.
Embodiment 3
The preparation of Radix Notoginseng (clip)
Weigh Radix Notoginseng (clip) 2000g meeting 2015 editions Chinese Pharmacopoeias, pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the Fructus Mali pumilae acid solution eluting of the pH5.0 of 7 times, then the sodium acetate liquid eluting of the pH8.0 with 8 times.Finally with pure
Water purification eluting causes below pH7.8；
(3), conveyer belt is drying to obtain Radix Notoginseng (clip) 1812g safely and efficiently.
This product, the content of arasaponin is 11.9%, microorganism, heavy metal and residual pesticide less than national standard/or
Do not detect.
Embodiment 4
The preparation of stem and leaf of Radix Notoginseng
Weigh standard compliant new fresh sanchi stems and leaves 2000g (water content about 60%), pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the malic acid of the pH4.0 of 9 times: acetic acid (1: 1) liquid eluting, then the sodium phosphate of the pH9.5 with 10 times: fructose
Acid sodium (2: 1) liquid eluting.Finally cause below pH7.8 with pure water eluting；
(3), the said goods, be drying to obtain safe stem and leaf of Radix Notoginseng 736g.
This product, the content of stem and leaf of Radix Notoginseng saponin is 8.3%, microorganism, heavy metal and residual pesticide less than national standard/
Or do not detect.
Embodiment 5
The preparation of Radix Notoginseng
Weigh Radix Notoginseng (countless head) 2000g meeting 2015 editions Chinese Pharmacopoeias, pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the acetate solution eluting of the pH5.4 of 8 times, then the sodium acetate liquid eluting of the pH8.0 with 10 times.
Finally cause below pH7.6 with pure water eluting；
(3), this product belt infrared drying i.e. obtains Radix Notoginseng 1889g safely.
This product, the content of arasaponin is 7.1%, and microorganism, heavy metal and residual pesticide are less than national standard/or not
Detection.
Embodiment 6
Radix Notoginseng micropowder (formula of 1000 bags):
Radix Notoginseng 10000g
Preparation technology: under conditions of 10,000 grades, by the Radix Notoginseng of recipe quantity micropowder technology super-refinement, by every bag of 10g bag
Dress, inspection, qualified, obtain the Radix Notoginseng micropowder (decoction pieces) that the safety of 1000 bags is high, the preservation of shady and cool place.
Embodiment 8
Notoginseng decoction piece
Prescription (1000 bags):
Weigh Radix Notoginseng (30) 2000g meeting 2015 editions Chinese Pharmacopoeias, pass through following process steps:
(1), first by satisfactory medical material carry out clean air wind wash, again by ultrasonic waves for cleaning, continue and wash with ozone, purify
Remove the dust of epidermis, foreign material and microorganism；
(2), with the acetate solution eluting of the pH5.4 of 8 times, then the sodium acetate liquid eluting of the pH8.0 with 10 times.Finally with pure
Water elution causes below pH7.6；
(3) take advantage of wet soft section, i.e. obtain notoginseng decoction piece 1849g safely with vacuum lyophilization, by every bag of 10g subpackage.
This product, the content of arasaponin is 3.5%, and microorganism, heavy metal and residual pesticide are less than national standard/or not
Detection.
Effect:
The panax species product safely and efficiently prepared by the present invention, our experiments show that:
One, stablize controlled: the product manufactured experimently at normal temperatures is placed 3 years, and product is stablized controlled, and indices is the most qualified, complete
Entirely meet the requirements；
Two, safety: product prepared by the integrated innovation technical matters through this case, pesticide residues and heavy metal all reach
Mark.Overcome these series products pesticide residues and the historical problem of heavy metals exceeding standard, to ensureing that product safety is helpful to.
1, stability test result:
In quality standard, assay and discriminating etc. are with reference to existing GB.Result is as follows:
Result shows sample prepared by this invention, investigates through primary stability, and product quality was basicly stable, up to 3 years
Above.
2, product pesticide residues and determining heavy metals
Foundation:
Main Basis CH.P 2015 and reference:
Element:
Organic agricultural chemicals:
Result:
Organic agricultural chemicals:
Result shows:
(1) the highest decline of heavy metal 72.5 times, minimum also decline 5.1 times；
(2) the highest decline of organic agricultural chemicals 22.0 times, minimum also decline 2.6 times；
(3) heavy metal and Organic pesticide residues fall are notable；
(4) heavy metal and Organic pesticide residues are after the technical program processes, even if originally the most significantly exceeding standard,
But finally can be well below standard matter；
(5) i.e. processing through the technical program, Panax's product is attained by subject invention and obtains the Panax of safety
Product.
3, the safety of product
Choosing the white mice 100 of 4.0 ± 0.6g weight in 10 day age, be divided into 3 groups, first group (33) use a unprocessed huge sum of money
Crude drug micropowder that genus, pesticide, microorganism all exceed standard (mix food, lower with), second group (33 example) with embodiment 6, the 3rd group (34
Example) use blank (same dosage feed medical starch).Dosage: every day presses 2000mg/1g.W, takes 90 days, every day continuously
Observation state, 30 days, 60 days, measurement body weight (g) in 90 days.
Result:
Note: 0 day be body weight during experiment beginning；* is notable with blank group comparing difference；* with blank group
The most variant.Difference between 1 group and 2 groups is more notable.
State: 3 groups, hair color, state are normal；2 groups, hair color relatively 3 groups more preferably, white mice state more preferably；1 group, hair color is poor,
Have that perpendicular hair, not gloss, diet is poor, body weight significantly lower than phenomenons such as other two groups, show long-term safety problem.
Conclusion: result shows that the product that the technical program provides can be obviously enhanced body constitution, has the healthy shape that improves significantly
The effect of condition.And same dosage, but the medical material that unprocessed heavy metal and pesticide remnant exceeds standard, then it is harmful to health.
With the above-mentioned desirable embodiment according to the present invention for enlightenment, by above-mentioned description, relevant staff is complete
Entirely can carry out various change and amendment in the range of without departing from this invention technological thought.The technology of this invention
The content that property scope is not limited in description, it is necessary to determine its technical scope according to right.
Claims (6)
1. the preparation technology of a panax species safely and efficiently, it is characterised in that: comprise the steps:
(1), first by medical material carry out that wind is washed, ultrasound wave is washed, ozone is washed, purify and remove the foreign material of epidermis, microorganism；
(2), with the weak acid liquid eluting of the pH4-6 of 5-10 times, then the weak lye eluting of the pH7.5-9.5 with 5-10 times, finally use
Pure water eluting causes pH7-8；
(3), by (2) products obtained therefrom, it is drying to obtain panax species.
The preparation technology of a kind of panax species safely and efficiently the most according to claim 1, it is characterised in that: described weak
Acid solution is phosphoric acid, sodium dihydrogen phosphate, the acid of sodium bisulfate ore deposit and/or acetic acid, lactic acid, citric acid, malic acid, fumaric acid, levulose
Acid organic acid.
The preparation technology of a kind of panax species safely and efficiently the most according to claim 2, it is characterised in that: described weak
Alkali liquor is sodium carbonate, sodium bicarbonate, disodium hydrogen phosphate inorganic base and/or sodium acetate, sodium lactate, natrium malicum, sodium citrate, really
Calciofon organic base.
The preparation technology of a kind of panax species safely and efficiently the most according to claim 2, it is characterised in that: described weak
The pH of acid solution is 4-6, and weak base pH is 7.5-9.5.
One the most according to any one of claim 1 to 4 panax species safely and efficiently, it is characterised in that: Radix Ginseng
The content of saponin is 3%-12%.
One the most according to claim 5 panax species safely and efficiently, it is characterised in that: described panax species is
Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494543A (en) * | 2020-04-22 | 2020-08-07 | 成都中医药大学 | Green processing technology of rhizoma polygonati |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156881A (en) * | 2007-09-27 | 2008-04-09 | 中国石油大学(北京) | A method for removing residue pesticides from Panax |
| CN104771427A (en) * | 2015-03-18 | 2015-07-15 | 昆明理工大学 | Method for reducing heavy metal content in traditional Chinese herbals |
| CN105433198A (en) * | 2015-12-04 | 2016-03-30 | 中南林业科技大学 | Method for decreasing heavy metal content in cereal powder |
-
2016
- 2016-07-19 CN CN201610587404.4A patent/CN106109519A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156881A (en) * | 2007-09-27 | 2008-04-09 | 中国石油大学(北京) | A method for removing residue pesticides from Panax |
| CN104771427A (en) * | 2015-03-18 | 2015-07-15 | 昆明理工大学 | Method for reducing heavy metal content in traditional Chinese herbals |
| CN105433198A (en) * | 2015-12-04 | 2016-03-30 | 中南林业科技大学 | Method for decreasing heavy metal content in cereal powder |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494543A (en) * | 2020-04-22 | 2020-08-07 | 成都中医药大学 | Green processing technology of rhizoma polygonati |
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Application publication date: 20161116 |