CN106109307A - The most non-stimulated a kind of sunscreen and preparation method thereof - Google Patents
The most non-stimulated a kind of sunscreen and preparation method thereof Download PDFInfo
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- CN106109307A CN106109307A CN201610575252.6A CN201610575252A CN106109307A CN 106109307 A CN106109307 A CN 106109307A CN 201610575252 A CN201610575252 A CN 201610575252A CN 106109307 A CN106109307 A CN 106109307A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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Abstract
The invention discloses the most non-stimulated a kind of sunscreen and preparation method thereof, this sunscreen includes the component of following weight portion: seed of Fructus Crataegi oil 30～40 parts, Radix et Caulis Opuntiae Dillenii extract 35～45 parts, Extraction of rutin thing 30～45 parts, Herba Rosmarini Officinalis extract 10～15 parts, Cellulose nanocrystal body 12～18 parts, cyclodextrin 50～70 parts, deionized water 100～120 parts.The sunscreen of the present invention is with seed of Fructus Crataegi oil, Radix et Caulis Opuntiae Dillenii extract and Extraction of rutin thing as main component, and adding Herba Rosmarini Officinalis extract and Cellulose nanocrystal body, water insoluble active ingredient therein, with cyclodextrin inclusion compound, belongs to oil-in-water, using the most moist, sensation is salubrious.Being found by experiment that, after using the sunscreen of the present invention, human body does not has any allergy and discomfort, illustrates that the sunscreen of the present invention has good safety, has non-stimulated feature.The sunscreen of the present invention is respectively provided with the sun-proof result of excellence to UVA Yu the UVB composition of ultraviolet.
Description
Technical field
The present invention relates to a kind of sunscreen, be specifically related to the most non-stimulated a kind of sunscreen and preparation method thereof.Belong to
Cosmetic technical field.
Background technology
Along with economic development and the raising of living standards of the people, lie fallow, travel, spending a holiday becomes new life and consumer
Formula.While enjoying the activities such as sandy beach, sunlight, outdoor pleasure trip on foot, ultraviolet to the injury of human body the most increasingly by people's
Paying attention to, therefore the use of sunscreen is the most increasingly extensive.
Ultraviolet divides three kinds: long wave UVA (wavelength 320～400), mainly makes skin darkening, activates tryrosinase, accelerates
Melanic generation, can destroy the collagen protein of skin corium simultaneously, causes skin to cross presenility, relax；Medium wave UVB (wavelength 280
～320), mainly make skin burn and make skin rubefaction, the change of skin epidermal cells can be caused, causing skin to occur shining
The situations such as speckle, erythema, sunburn；Shortwave UVC (wavelength 200～280), nocuity is the strongest, but the overwhelming majority is absorbed by ozone layer,
The least to our harm.So our anti-ultraviolet, mainly uv blocking A and UVB280～400 these wave bands.
Conventional Orangic sunscreen (chemical sunscreen) such as poplar Barbiturates, cinnamic acid salt, anthranilate class etc., this
A little materials have strong ultra-violet absorption function.Inorganic sunscreen (physical sunscreen) mainly titanium dioxide, zinc oxide, both
Inorganic matter is present in the coating of sunscreen with powder body composite form, does not only have the effect absorbing ultraviolet, and its complex is special
Property also can reflect, reflect a part of ultraviolet.It is to say, physical sunscreen is that light-reflecting particles forms protection on skin
Wall；Chemical sunscreen is exactly with chemical substance and Cell binding, reaches to absorb the ultraviolet effect of certain part wavelength.General sunscreen
In organic and inorganic sunscreen all can use.Both methods are entirely different, are respectively arranged with its feature.
The particle of physical sunscreen need not absorb, can be smaller to the burden of skin, but shortcoming is it is also obvious that particle ratio
Relatively big, seem on skin whiting, and the most viscous, greasy, although present workmanship is thin more a lot of than in the past, but still can not be complete
Entirely overcoming this shortcoming, for the people of dry skin, the moistness of physical sunscreen agent is the poorest, and needs special
Makeup removing, common cleansing milk cannot clean thoroughly.Chemical sunscreen needs to absorb, so to make by competence exertion after smearing 20 minutes
With, general transparent clearly, but some people is big to the probability of certain composition allergy.Because a lot of material ripples to the absorption of ultraviolet
Long scope is wide not, typically wants several chemical substances jointly to act on, and just can sponge the ultraviolet of great majority injury skin.
Summary of the invention
It is an object of the invention to as overcoming above-mentioned the deficiencies in the prior art, it is provided that the most non-stimulated a kind of sunscreen.
Present invention also offers its preparation method.
For achieving the above object, the present invention uses following technical proposals:
The most non-stimulated a kind of sunscreen, including the component of following weight portion: seed of Fructus Crataegi oil 30～40 parts, Radix et Caulis Opuntiae Dillenii carries
Take thing 35～45 parts, Extraction of rutin thing 30～45 parts, Herba Rosmarini Officinalis extract 10～15 parts, Cellulose nanocrystal body 12～18 parts,
Cyclodextrin 50～70 parts, deionized water 100～120 parts.
Preferably, described cyclodextrin is HP-β-CD.
Described sunscreen also includes following components: glyceryl monostearate 10～18 parts, vaseline 15～20 parts, 1,2-
Propylene glycol 11～15 parts, glycerol 12～16 parts, span 8～12 parts, tween 9～14 parts, methyl hydroxybenzoate 10～15 parts.
It is further preferred that described span is Arlacel-60, described tween is Tween-60.
Described sunscreen also includes following components: octadecanol 10～15 parts, polydimethylsiloxane 12～18 parts, 2-
Bromo-2-nitro-1,3 propylene glycol 11～16 parts.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 10～20 minutes, add step
(1) gained mixture, is heated to 30～45 DEG C, and stirring, until forming uniform suspension；
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 20～30 minutes, to obtain final product.
Preferably, step (2) gained suspension continuously adds the glyceryl monostearate of formula ratio, vaseline, 1,2-
Propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and 2-bromo-2-nitro-1,3 the third two
Alcohol, and continue to stir, until forming uniform suspension under the conditions of 30～45 DEG C.
Preferably, the described Extraction of rutin thing in step (1) extracts by the following method and obtains: the rutin that will dry
Pulverizing through high speed disintegrator, with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave merit
Rate 750W, extracts 10 minutes, filters, extracting solution recovered under reduced pressure normal hexane, obtains the Extraction of rutin thing of powder.
Preferably, the described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh fan repeatedly
Fragrant branch and leaf are placed in baking oven, and controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours,
Obtain Herba Rosmarini Officinalis cured leaf；(2), by Herba Rosmarini Officinalis cured leaf loading utilizes siphon principle to it with ethanol extraction in apparatus,Soxhlet's, carry
The time of taking controls at 2～6 hours, and Extracting temperature is 85 DEG C；Under conditions of vacuum 0.094～0.096MPa, extracting solution is entered
Row rotary evaporation in vacuo, obtains the Herba Rosmarini Officinalis extract of powder.
Preferably, the described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, mistake
100 mesh sieves, with petroleum ether as Extraction solvent, mix homogeneously petroleum ether with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 points
Clock, filters, and takes filtrate, and rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, to obtain final product
The mean diameter seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Beneficial effects of the present invention:
The sunscreen of the present invention is with seed of Fructus Crataegi oil, Radix et Caulis Opuntiae Dillenii extract and Extraction of rutin thing as main component, and adds
Herba Rosmarini Officinalis extract and Cellulose nanocrystal body, water insoluble active ingredient therein with cyclodextrin inclusion compound, belongs to oil-in-water, uses
Moistening very much, sensation is salubrious.Being found by experiment that, after using the sunscreen of the present invention, human body does not has any allergy and discomfort,
Illustrate that the sunscreen of the present invention has good safety, there is non-stimulated feature.The sunscreen of the present invention is to ultraviolet
UVA Yu UVB composition is respectively provided with the sun-proof result of excellence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further elaborated, it should explanation, the description below merely to
Explain the present invention, its content is not defined.
Radix et Caulis Opuntiae Dillenii extract, purchased from Shaanxi Sen Fusuo Bioisystech Co., Ltd.
Embodiment 1:
A kind of the most non-stimulated sunscreen of the present invention, including following components: seed of Fructus Crataegi oil 30kg, Radix et Caulis Opuntiae Dillenii extract
35kg, Extraction of rutin thing 30kg, Herba Rosmarini Officinalis extract 10kg, Cellulose nanocrystal body 12kg, HP-β-CD 50kg,
Deionized water 100kg, glyceryl monostearate 10kg, vaseline 15kg, 1,2-PD 11kg, glycerol 12kg, Arlacel-60
8kg, Tween-60 9kg, methyl hydroxybenzoate 10kg, octadecanol 10kg, polydimethylsiloxane 12kg, 2-bromo-2-nitro-1,3
Propylene glycol 11kg.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 10 minutes, add step (1)
Gained mixture, is heated to 30 DEG C, and stirring, until forming uniform suspension；Continuously add the glycerol monostearate of formula ratio
Ester, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and the bromo-2-of 2-
Nitro-1,3 propylene glycol, and continue to stir, until forming uniform suspension under the conditions of 30 DEG C.
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 20 minutes, to obtain final product.
Described Extraction of rutin thing in step (1) extracts by the following method and obtains: by the rutin of drying through at a high speed
Pulverizer is pulverized, and with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave power 750W,
Extract 10 minutes, filter, extracting solution recovered under reduced pressure normal hexane, obtain the Extraction of rutin thing of powder.
Described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh Herba Rosmarini Officinalis branch and leaf
Being placed in baking oven, controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours, is confused
Repeatedly smoked bean curd leaf；(2), Herba Rosmarini Officinalis cured leaf loading apparatus,Soxhlet's will utilize siphon principle that it is used ethanol extraction, extraction time
Controlling at 2 hours, Extracting temperature is 85 DEG C；Under conditions of vacuum 0.094MPa, extracting solution is carried out rotary evaporation in vacuo, i.e.
Obtain the Herba Rosmarini Officinalis extract of powder.
Described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves,
With petroleum ether as Extraction solvent, petroleum ether is mixed homogeneously with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 minutes, filter,
Taking filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, obtains mean diameter
Seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Embodiment 2:
A kind of the most non-stimulated sunscreen of the present invention, including following components: seed of Fructus Crataegi oil 40kg, Radix et Caulis Opuntiae Dillenii extract
45kg, Extraction of rutin thing 45kg, Herba Rosmarini Officinalis extract 15kg, Cellulose nanocrystal body 18kg, HP-β-CD 70kg,
Deionized water 120kg, glyceryl monostearate 18kg, vaseline 20kg, 1,2-PD 15kg, glycerol 16kg, Arlacel-60
8kg, Tween-60 9kg, methyl hydroxybenzoate 15kg, octadecanol 15kg, polydimethylsiloxane 18kg, 2-bromo-2-nitro-1,3
Propylene glycol 16kg.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 20 minutes, add step (1)
Gained mixture, is heated to 45 DEG C, and stirring, until forming uniform suspension；Continuously add the glycerol monostearate of formula ratio
Ester, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and the bromo-2-of 2-
Nitro-1,3 propylene glycol, and continue to stir, until forming uniform suspension under the conditions of 45 DEG C.
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 30 minutes, to obtain final product.
Described Extraction of rutin thing in step (1) extracts by the following method and obtains: by the rutin of drying through at a high speed
Pulverizer is pulverized, and with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave power 750W,
Extract 10 minutes, filter, extracting solution recovered under reduced pressure normal hexane, obtain the Extraction of rutin thing of powder.
Described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh Herba Rosmarini Officinalis branch and leaf
Being placed in baking oven, controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours, is confused
Repeatedly smoked bean curd leaf；(2), Herba Rosmarini Officinalis cured leaf loading apparatus,Soxhlet's will utilize siphon principle that it is used ethanol extraction, extraction time
Controlling at 6 hours, Extracting temperature is 85 DEG C；Under conditions of vacuum 0.096MPa, extracting solution is carried out rotary evaporation in vacuo, i.e.
Obtain the Herba Rosmarini Officinalis extract of powder.
Described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves,
With petroleum ether as Extraction solvent, petroleum ether is mixed homogeneously with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 minutes, filter,
Taking filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, obtains mean diameter
Seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Embodiment 3:
A kind of the most non-stimulated sunscreen of the present invention, including following components: seed of Fructus Crataegi oil 32kg, Radix et Caulis Opuntiae Dillenii extract
36kg, Extraction of rutin thing 31kg, Herba Rosmarini Officinalis extract 11kg, Cellulose nanocrystal body 13kg, HP-β-CD 51kg,
Deionized water 105kg, glyceryl monostearate 12kg, vaseline 17kg, 1,2-PD 12kg, glycerol 13kg, Arlacel-60
9kg, Tween-60 10kg, methyl hydroxybenzoate 11kg, octadecanol 11kg, polydimethylsiloxane 13kg, 2-bromo-2-nitro-1,3
Propylene glycol 12kg.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 12 minutes, add step (1)
Gained mixture, is heated to 35 DEG C, and stirring, until forming uniform suspension；Continuously add the glycerol monostearate of formula ratio
Ester, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and the bromo-2-of 2-
Nitro-1,3 propylene glycol, and continue to stir, until forming uniform suspension under the conditions of 35 DEG C.
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 25 minutes, to obtain final product.
Described Extraction of rutin thing in step (1) extracts by the following method and obtains: by the rutin of drying through at a high speed
Pulverizer is pulverized, and with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave power 750W,
Extract 10 minutes, filter, extracting solution recovered under reduced pressure normal hexane, obtain the Extraction of rutin thing of powder.
Described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh Herba Rosmarini Officinalis branch and leaf
Being placed in baking oven, controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours, is confused
Repeatedly smoked bean curd leaf；(2), Herba Rosmarini Officinalis cured leaf loading apparatus,Soxhlet's will utilize siphon principle that it is used ethanol extraction, extraction time
Controlling at 3 hours, Extracting temperature is 85 DEG C；Under conditions of vacuum 0.094MPa, extracting solution is carried out rotary evaporation in vacuo, i.e.
Obtain the Herba Rosmarini Officinalis extract of powder.
Described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves,
With petroleum ether as Extraction solvent, petroleum ether is mixed homogeneously with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 minutes, filter,
Taking filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, obtains mean diameter
Seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Embodiment 4:
A kind of the most non-stimulated sunscreen of the present invention, including following components: seed of Fructus Crataegi oil 38kg, Radix et Caulis Opuntiae Dillenii extract
42kg, Extraction of rutin thing 40kg, Herba Rosmarini Officinalis extract 14kg, Cellulose nanocrystal body 17kg, HP-β-CD 65kg,
Deionized water 118kg, glyceryl monostearate 17kg, vaseline 19kg, 1,2-PD 14kg, glycerol 15kg, Arlacel-60
11kg, Tween-60 13kg, methyl hydroxybenzoate 14kg, octadecanol 14kg, polydimethylsiloxane 17kg, 2-bromo-2-nitro-1,
3 propylene glycol 15kg.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 20 minutes, add step (1)
Gained mixture, is heated to 30 DEG C, and stirring, until forming uniform suspension；Continuously add the glycerol monostearate of formula ratio
Ester, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and the bromo-2-of 2-
Nitro-1,3 propylene glycol, and continue to stir, until forming uniform suspension under the conditions of 30 DEG C.
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 20 minutes, to obtain final product.
Described Extraction of rutin thing in step (1) extracts by the following method and obtains: by the rutin of drying through at a high speed
Pulverizer is pulverized, and with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave power 750W,
Extract 10 minutes, filter, extracting solution recovered under reduced pressure normal hexane, obtain the Extraction of rutin thing of powder.
Described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh Herba Rosmarini Officinalis branch and leaf
Being placed in baking oven, controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours, is confused
Repeatedly smoked bean curd leaf；(2), Herba Rosmarini Officinalis cured leaf loading apparatus,Soxhlet's will utilize siphon principle that it is used ethanol extraction, extraction time
Controlling at 5 hours, Extracting temperature is 85 DEG C；Under conditions of vacuum 0.096MPa, extracting solution is carried out rotary evaporation in vacuo, i.e.
Obtain the Herba Rosmarini Officinalis extract of powder.
Described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves,
With petroleum ether as Extraction solvent, petroleum ether is mixed homogeneously with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 minutes, filter,
Taking filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, obtains mean diameter
Seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Embodiment 5:
A kind of the most non-stimulated sunscreen of the present invention, including following components: seed of Fructus Crataegi oil 35kg, Radix et Caulis Opuntiae Dillenii extract
38kg, Extraction of rutin thing 40kg, Herba Rosmarini Officinalis extract 12kg, Cellulose nanocrystal body 15kg, HP-β-CD 60kg,
Deionized water 110kg, glyceryl monostearate 15kg, vaseline 17kg, 1,2-PD 13kg, glycerol 14kg, Arlacel-60
10kg, Tween-60 11kg, methyl hydroxybenzoate 13kg, octadecanol 12kg, polydimethylsiloxane 15kg, 2-bromo-2-nitro-1,
3 propylene glycol 14kg.
The preparation method of above-mentioned sunscreen, including step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed,
Mix homogeneously, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 20 minutes, add step (1)
Gained mixture, is heated to 40 DEG C, and stirring, until forming uniform suspension；Continuously add the glycerol monostearate of formula ratio
Ester, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, polydimethylsiloxane and the bromo-2-of 2-
Nitro-1,3 propylene glycol, and continue to stir, until forming uniform suspension under the conditions of 40 DEG C.
(3) being poured into by step (2) gained suspension in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W surpasses
Sound oscillation 25 minutes, to obtain final product.
Described Extraction of rutin thing in step (1) extracts by the following method and obtains: by the rutin of drying through at a high speed
Pulverizer is pulverized, and with normal hexane as Extraction solvent, the mass volume ratio of rutin and normal hexane is 1g:20mL, microwave power 750W,
Extract 10 minutes, filter, extracting solution recovered under reduced pressure normal hexane, obtain the Extraction of rutin thing of powder.
Described Herba Rosmarini Officinalis extract in step (1) extracts by the following method and obtains: by fresh Herba Rosmarini Officinalis branch and leaf
Being placed in baking oven, controlling temperature is 100 DEG C of drying, removes moisture and volatile oil in Herba Pelargonii Graveolentis, and drying time is 5 hours, is confused
Repeatedly smoked bean curd leaf；(2), Herba Rosmarini Officinalis cured leaf loading apparatus,Soxhlet's will utilize siphon principle that it is used ethanol extraction, extraction time
Controlling at 5 hours, Extracting temperature is 85 DEG C；Under conditions of vacuum 0.096MPa, extracting solution is carried out rotary evaporation in vacuo, i.e.
Obtain the Herba Rosmarini Officinalis extract of powder.
Described seed of Fructus Crataegi oil in step (3) extracts by the following method and obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves,
With petroleum ether as Extraction solvent, petroleum ether is mixed homogeneously with seed of Fructus Crataegi oil, 40 DEG C, 200W ultrasonic extraction 30 minutes, filter,
Taking filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine or nanometer ram machine to carry out miniaturization process, obtains mean diameter
Seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder is 1g:10mL with the mass volume ratio of petroleum ether.
Test example 1
Irritation test
120 example experimenters, are randomly divided into 6 groups, often organize 20 people, take 0.03ml sample with syringe and are placed in the medicine of speckle examination adhesive tape
Indoor, try the speckle being equipped with sample adhesive tape immediately and start from bottom to be longitudinally affixed on the normal skin of left forearm, the lightest
Pressing room is to drive away air, and makes trier be uniformly distributed.Labelling is carried out at test position, in order to observe.Skin is pasted every 24 hours
Once, open half an hour after paster, then checked according to the term of CTFA guide (1981).6 speckles are carried out altogether
Sturdy test, patch skin terminate after the 6th day, in order to observe late response, carried out additional inspection.Data then utilize last inspection
Come to an end fruit, compares.Identify and carry out for standard with table 1.Substances is respectively sunscreen and the blank of embodiment 1～5
The cyclodextrin of equivalent and deionized water (are fully mixed and obtain) by group, the results are shown in Table 2.
Table 1. standard of perfection
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, pimple, blister |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Table 2. irritation test result
From Table 2, it can be seen that after using the sunscreen of the present invention, human body does not has any allergy and discomfort, and this is described
Bright sunscreen has good safety, has non-stimulated feature.
Test example 2
Sun-proof result is tested
Blank quartz plate test background curve, then precise 0.2mg/cm is used before sample test2Sample is in 3M adhesive tape
On face, then with the finger rapid application homogeneous sample of the upper latex finger cot of band.Sample panel after smearing is done at shady and cool naturally
Dry 30min.Upper Instrument measuring, can record the sun-proof value of UVA Yu UVB, represent with spf value with PA value respectively.Spf value is basis
Minimum Erythema Dose determines: the minimum Erythema Dose of SPF=(after sun-proof articles)/minimum Erythema Dose (uses sun-proof articles
Before)；The numerical value of SPF SPF (sun protection factor) is applicable to everyone, and its computational methods are: assume that the intensity of ultraviolet will not change because of the time
Become, if one does not has the people of any sun-proof measure skin after in the sun 20 minutes to redden, when he uses preventing of SPF15
During solarization product, representing the time that can extend 15 times, namely after 300 minutes, skin just can be shone red；And PA value is the most in the world
There is no unified standard, with PA (Protection grade of UVA, PA), Japanese cosmetic TIA represents that UVA's is anti-
Protect grade.PA carries out classification according to UVA protecting factor (Protection factor of UVA, PFA), and it protects UVA effect
The method for expressing of grade is: 2≤PFA ＜ 4 is PA+；4≤PFA ＜ 8 is PA++；8≤PFA is PA+++；
The substances of this test experiments is respectively the sunscreen of embodiment 1～5 with blank group (by the cyclodextrin of equivalent
Fully mix with deionized water and obtain).Instrument title used by test is SPF-290S.Test result is as shown in table 3.
Table 3. sun-proof result result of the test
| Spf value | PA value | |
| Embodiment 1 | 40 | 9(PA+++) |
| Embodiment 2 | 40 | 9(PA+++) |
| Embodiment 3 | 42 | 9(PA+++) |
| Embodiment 4 | 42 | 9(PA+++) |
| Embodiment 5 | 45 | 9(PA+++) |
| Blank group | 0 | 0 |
From table 3 it can be seen that the sunscreen of the present invention is respectively provided with the sun-proof effect of excellence to UVA Yu the UVB composition of ultraviolet
Really.
Although the above-mentioned detailed description of the invention to the present invention is described, but not limit to scope
System, on the basis of technical scheme, those skilled in the art need not to pay that creative work can make is each
Plant amendment or deformation still within protection scope of the present invention.
Claims (8)
1. a salubrious non-stimulated sunscreen, it is characterised in that include the component of following weight portion: seed of Fructus Crataegi oil 30～40
Part, Radix et Caulis Opuntiae Dillenii extract 35～45 parts, Extraction of rutin thing 30～45 parts, Herba Rosmarini Officinalis extract 10～15 parts, Cellulose nanocrystal
Body 12～18 parts, cyclodextrin 50～70 parts, deionized water 100～120 parts.
2. according to the sunscreen described in claim, it is characterised in that described sunscreen also includes following components: monostearate
Glyceride 10～18 parts, vaseline 15～20 parts, 1,2-PD 11～15 parts, glycerol 12～16 parts, span 8～12 parts, tell
Temperature 9～14 parts, methyl hydroxybenzoate 10～15 parts.
3. according to the sunscreen described in claim, it is characterised in that described sunscreen also includes following components: octadecanol 10
～15 parts, polydimethylsiloxane 12～18 parts, 2-bromo-2-nitro-1,3 propylene glycol 11～16 parts.
4. the preparation method of sunscreen according to any one of claims 1 to 3, it is characterised in that include step:
(1) Radix et Caulis Opuntiae Dillenii extract of formula ratio, Extraction of rutin thing, Herba Rosmarini Officinalis extract and Cellulose nanocrystal body are weighed, mixing
Uniformly, standby；
(2) reaction vessel is sequentially added into deionized water and the cyclodextrin of formula ratio, stirs 10～20 minutes, add step (1)
Gained mixture, is heated to 30～45 DEG C, and stirring, until forming uniform suspension；
(3) step (2) gained suspension is poured in another reaction vessel of the seed of Fructus Crataegi oil filling formula ratio, 200W Under Ultrasonic Vibration
Swing 20～30 minutes, to obtain final product.
Preparation method the most according to claim 4, it is characterised in that continuously add formula in step (2) gained suspension
The glyceryl monostearate of amount, vaseline, 1,2-propylene glycol, glycerol, span, tween, methyl hydroxybenzoate, octadecanol, poly-diformazan
Radical siloxane and 2-bromo-2-nitro-1,3 propylene glycol, and continue to stir under the conditions of 30～45 DEG C, until forming uniform suspension
Liquid.
Preparation method the most according to claim 4, it is characterised in that the described Extraction of rutin thing in step (1) is to pass through
Following methods extracts and obtains: pulverized through high speed disintegrator by the rutin dried, with normal hexane as Extraction solvent, and rutin and just own
The mass volume ratio of alkane is 1g:20mL, microwave power 750W, extracts 10 minutes, filters, extracting solution recovered under reduced pressure normal hexane, i.e.
Obtain the Extraction of rutin thing of powder.
Preparation method the most according to claim 4, it is characterised in that the described Herba Rosmarini Officinalis extract in step (1) is logical
Crossing what following methods extraction obtained: be placed in baking oven by fresh Herba Rosmarini Officinalis branch and leaf, controlling temperature is 100 DEG C of drying, removes Herba Pelargonii Graveolentis
Middle moisture and volatile oil, drying time is 5 hours, obtains Herba Rosmarini Officinalis cured leaf；(2), Herba Rosmarini Officinalis cured leaf is loaded apparatus,Soxhlet's
In utilize siphon principle to it with ethanol extraction, extraction time controls at 2～6 hours, and Extracting temperature is 85 DEG C；Vacuum
Under conditions of 0.094～0.096MPa, extracting solution is carried out rotary evaporation in vacuo, obtain the Herba Rosmarini Officinalis extract of powder.
Preparation method the most according to claim 4, it is characterised in that the described seed of Fructus Crataegi oil in step (3) be by with
The extraction of lower method obtains: seed of Fructus Crataegi is pulverized, and crosses 100 mesh sieves, with petroleum ether as Extraction solvent, is mixed with seed of Fructus Crataegi oil by petroleum ether
Close uniformly, 40 DEG C, 200W ultrasonic extraction 30 minutes, to filter, take filtrate, rotation is evaporated off petroleum ether, uses superhigh-voltage homogenizing machine
Or nanometer ram machine carries out miniaturization process, obtain the mean diameter seed of Fructus Crataegi oil less than 150nm；Seed of Fructus Crataegi powder and petroleum ether
Mass volume ratio is 1g:10mL.
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| CN108703928A (en) * | 2018-08-06 | 2018-10-26 | 李媛媛 | A kind of whitening spot-removing moisturizing gel and preparation method thereof |
| WO2018209449A1 (en) * | 2017-05-18 | 2018-11-22 | Medena Ag | Use of naturally glycosylated polyphenols as protective agents against the effects of ultraviolet irradiation |
| FR3070862A1 (en) * | 2017-09-14 | 2019-03-15 | Quanshen Liu | SKIN WHITENING AND SOLAR PROTECTION COMPOSITION COMPRISING NANO MATERIALS AND EXTRACT FROM CHINESE MEDICINE |
| CN115869232A (en) * | 2022-12-30 | 2023-03-31 | 武汉纺织大学 | Sunscreen composition and sunscreen agent comprising natural plant extract |
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| FR3070862A1 (en) * | 2017-09-14 | 2019-03-15 | Quanshen Liu | SKIN WHITENING AND SOLAR PROTECTION COMPOSITION COMPRISING NANO MATERIALS AND EXTRACT FROM CHINESE MEDICINE |
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| CN115869232A (en) * | 2022-12-30 | 2023-03-31 | 武汉纺织大学 | Sunscreen composition and sunscreen agent comprising natural plant extract |
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