CN106103686A - There is the sample cell assembly that improved leakage is taken precautions against - Google Patents
There is the sample cell assembly that improved leakage is taken precautions against Download PDFInfo
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- CN106103686A CN106103686A CN201480066330.9A CN201480066330A CN106103686A CN 106103686 A CN106103686 A CN 106103686A CN 201480066330 A CN201480066330 A CN 201480066330A CN 106103686 A CN106103686 A CN 106103686A
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- upper wall
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- 238000001179 sorption measurement Methods 0.000 claims abstract description 115
- 230000002093 peripheral effect Effects 0.000 claims abstract description 39
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- 239000000565 sealant Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 238000010521 absorption reaction Methods 0.000 claims description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 4
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- 238000000429 assembly Methods 0.000 claims 7
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 78
- 239000000463 material Substances 0.000 description 18
- 239000000443 aerosol Substances 0.000 description 10
- 229920002725 thermoplastic elastomer Polymers 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
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- 239000007787 solid Substances 0.000 description 5
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- -1 polypropylene Polymers 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
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- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 229920006465 Styrenic thermoplastic elastomer Polymers 0.000 description 2
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
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- 238000009434 installation Methods 0.000 description 2
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- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
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- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical class C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
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- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/141—Preventing contamination, tampering
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/043—Hinged closures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention provides and there is sample cell and the pipette termination that improved leakage is taken precautions against.This sample cell has the hollow tube of the upper wall portions of substantially cylindrical, and described upper wall portions limits the opening of described hollow tube in its marginal portion.This sample cell includes the sealing cap with the component being generally formed into cylinder, and wherein, when sealing cap and engaging to close described opening with hollow tube, the described component being generally formed into cylinder becomes to be in sealing contact with the inner peripheral surface of described upper wall portions.Described sample cell farther includes the adsorption layer that the opening around hollow tube is installed, and described adsorption layer is in order to adsorb the sample from hollow tube leakage.
Description
Cross-Reference to Related Applications
This application claims the excellent of No. 201310639182.2 Chinese patent application of Application No. submitted on December 4th, 2013
First weigh, during entire contents is incorporated herein by reference.
Technical field
The invention mainly relates to the sample cell for processing liquid reagent and for moving the pipettor termination of liquid, specifically
Relate to the sample cell that there is improved leakproof and be particularly well-suited to thermal cycle reaction, preparation of samples and storage, and there is improvement
Leakage and cross pollution take precautions against pipettor termination.
Background technology
Molecular biology experiment is carried out under little reaction volume, and has improved constantly flux, often requires that high temperature in addition
Environment.Normally, biological sample to be analyzed is only a small amount of available.Furthermore, it is necessary to reduce reagent consumption, especially at business neck
In territory, it is desirable to the minimum of reaction volume.When heated (for example, in PCR experiment), the biological sample of receiving in sample cell
May leak out from sample cell in the form of an aerosol.This sample leakage may cause environmental pollution or different sample cell
Between cross pollution.Therefore, there is further improved demand always.
Content of the invention
The invention provides and there is the sample cell that improved leakage is taken precautions against.Use this sample cell can be effectively prevented from sample
Leakage pollution experimental situation.
Therefore, in a first aspect of the present invention, the present invention provides the hollow of a kind of upper wall portions including substantially cylindrical
Body sample cell, described upper wall portions limits the opening of described hollow tube in its marginal portion.Described sample cell has substantially shape
Become the sealing cap of cylindrical component, when sealing cap and engaging to close described opening with hollow tube, described substantially form
Become to be in sealing contact with the inner peripheral surface of described upper wall portions for cylindrical component；Described sample cell farther includes around hollow tube
Opening install adsorption layer, described adsorption layer in order to adsorb from hollow tube leakage sample.
In second aspect, the invention provides the sample of the hollow tube of a kind of upper wall portions including having substantially cylindrical
QC, described upper wall portions limits the opening of described hollow tube in its marginal portion；There is the component being generally formed into cylinder
Sealing cap, when sealing cap and engaging to close described opening with hollow tube, described be generally formed into cylindrical component and
The inner peripheral surface of described upper wall portions is in sealing contact；And invest the described adsorption layer sealing cap, engage with hollow tube when sealing cap
With close described opening when, described adsorption layer around upper wall portions with adsorb from hollow tube leakage sample.
In the third aspect, the invention provides the sample of the hollow tube of a kind of upper wall portions including having substantially cylindrical
QC, described upper wall portions limits the opening of described hollow tube in its marginal portion；There is the component being generally formed into cylinder
Sealing cap, described be generally formed into cylinder component be skirt, and when seal cap engage with hollow tube to close
When stating opening, the described component being generally formed into cylinder is outside the outer peripheral face of described upper wall portions；And described in investing substantially
Be formed as the adsorption layer of the inner surface of cylindrical component, and described adsorption layer by be generally formed into the component of cylinder with
Axle ground is arranged, thus when sealing cap and engaging to close described opening with hollow tube, described adsorption layer is around hollow tube
Upper wall portions is to adsorb the sample from hollow tube leakage.
In fourth aspect, the invention provides a kind of sample cell bar.Described sample cell bar has multiple hollow tube, each
Hollow tube is respectively provided with the upper wall portions of substantially cylindrical, and the plurality of hollow tube linear array is arranged symmetrically, thus
Their axis is parallel to each other, and described upper wall portions limits the opening of described hollow tube in its marginal portion；And multiple sealing
The linear array that cap is constituted, each sealing cap is in sealing contact with one of multiple hollow tubes, and in multiple sealing cap
Any two adjacent members is connected by tethers；Wherein each hollow tube all includes installing around the opening of described hollow tube
Adsorption layer, described adsorption layer in order to adsorb from hollow tube leakage sample.
At the 5th aspect, the invention provides a kind of sample cell bar, this sample cell bar includes multiple hollow tube, in each
Blank pipe body is respectively provided with the upper wall portions of substantially cylindrical, and the plurality of hollow tube linear array is arranged symmetrically, thus it
Axis be parallel to each other, described upper wall portions limits the opening of described hollow tube in its marginal portion；And multiple sealing cap
The linear array constituting, each seals cap and is in sealing contact with one of multiple hollow tubes, and appointing in multiple sealing cap
Two adjacent members of anticipating are connected by tethers；Each seal cap be respectively provided be generally formed into cylinder component, when seal cap with
Hollow tube engage to close described opening when, described be generally formed into cylinder component close with the inner peripheral surface of described upper wall portions
Sealing-in is touched；And each seals cap and is respectively provided with adsorption layer, when sealing cap and engaging to close described opening with hollow tube, described
Adsorption layer around upper wall portions with adsorb from hollow tube leakage sample.
At the 6th aspect, the invention provides a kind of sample cell bar.Described sample cell bar includes multiple hollow tube, each
Hollow tube is respectively provided with the upper wall portions of substantially cylindrical, and the plurality of hollow tube linear array is arranged symmetrically, thus
Their axis is parallel to each other, and described upper wall portions limits the opening of described hollow tube in its marginal portion；And multiple sealing
The linear array that cap is constituted, each sealing cap is in sealing contact with one of multiple hollow tubes, and in multiple sealing cap
Any two adjacent members is connected by tethers；Each seals cap and is respectively provided with the component being generally formed into cylinder, which is skirt,
When sealing cap and engaging to close described opening with hollow tube, the described component being generally formed into cylinder is in described upper wall portions
Outer peripheral face outside；And each seal cap be respectively provided with invest described in be generally formed into the absorption of inner surface of component of cylinder
Layer, and described adsorption layer by with the component coaxial being generally formed into cylinder arrange, thus when sealing cap and hollow tube
Engage to seal described opening when, described adsorption layer around hollow tube upper wall portions with adsorb from hollow tube leakage sample
Product.
At the 7th aspect, the invention provides a kind of porous plate assembly.Described porous plate assembly includes having support chip
Plate body, described support chip has multiple hole wherein, and each hole is respectively provided with opening, closed bottom, and extends both it
Between sidewall, at least one in wherein said multiple holes has the upper wall portions of substantially cylindrical, and described upper wall portions is on its limit
Edge portion limits described opening, and upwardly extends from support chip at least in part；Wherein each hole is respectively provided with and invests on described
Wall portion outer surface and the adsorption layer of the opening around described hole, with absorption from the sample of described hole leakage.
In eighth aspect, the invention provides a kind of porous plate assembly.Described porous plate assembly includes having support chip
Plate body, described support chip has multiple hole wherein, and each hole is respectively provided with opening, closed bottom, and extends both it
Between sidewall, at least one in wherein said multiple holes has the upper wall portions of substantially cylindrical, and described upper wall portions is on its limit
Edge portion limits described opening, and upwardly extends from support chip at least in part；The array that multiple sealing caps are constituted, wherein often
Individual sealing cap is in sealing contact with one of multiple holes, and multiple sealing caps are linked together by connecting piece；It is equal that each seals cap
There is the component being generally formed into cylinder, when sealing cap and engaging to close described opening with described hole, described substantially form
Inner peripheral surface for cylindrical component and described upper wall portions is in sealing contact；And each seals cap and is respectively provided with adsorption layer, work as sealing
When cap engages with described hole to close described opening, described adsorption layer around the upper wall portions of substantially cylindrical to adsorb from described
The sample of hole leakage.
At the 9th aspect, the invention provides a kind of porous plate assembly.Described porous plate assembly includes having support chip
Plate body, described support chip has multiple hole wherein, and each hole is respectively provided with opening, closed bottom, and extends both it
Between sidewall, at least one in wherein said multiple holes has the upper wall portions of substantially cylindrical, and described upper wall portions is on its limit
Edge portion limits described opening, and upwardly extends from support chip at least in part；The array of multiple sealing caps, wherein each is close
Sealing cap is in sealing contact with one of multiple holes, and multiple sealing caps are linked together by connecting piece；Each seals cap and is respectively provided with
Be generally formed into cylinder component, which is skirt, when seal cap engage with described hole to close described opening when, described substantially
Be formed as outside the outer peripheral face of the cylindrical component upper wall portions in described substantially cylindrical；Each sealing cap is respectively provided with and invests
The adsorption layer of inner surface of the described component being generally formed into cylinder, and described adsorption layer by be generally formed into cylinder
Component coaxial ground arrange, thus when sealing cap and engaging to seal described opening with described hole, described adsorption layer is around described
The upper wall portions of the substantially cylindrical in hole is to adsorb the sample from hole leakage.
At the tenth aspect, the invention provides a kind of pipettor tip member, this pipettor tip member is for departing from
Ground coupling pipettor body transfer liquid.Described pipettor tip member has elongated tubular container, described tubular container
Including: for receiving the proximal openings of pipettor body；For the distal tip opening from pipettor tip member distribution liquid；
And the upper wall portions adjacent with described proximal openings for engaging with described pipettor body removedly；And invest described
The filter element of upper wall portions inner peripheral surface, for avoiding the sample being contained in described pipettor tip member to flow out via it, its
Described in filter element include the porous carrier that is wherein scattered with absorbability particle.
In conjunction with the embodiment enclosed with reference to the detailed description of the subsequently present invention, the present invention as previously mentioned and other
Advantage and feature and other the mode similarly completing will more become apparent from, and these illustrate preferably and show
The embodiment of model.
Brief description
Fig. 1 is the sectional view of sample cell according to an embodiment of the invention；
Fig. 2 is the sectional view of sample cell in accordance with another embodiment of the present invention；
Fig. 3 is the sectional view of the sample cell according to another embodiment of the present invention；
Fig. 3 A be the sample cell shown in Fig. 3 seal lid be inserted into body when, the sectional view of its upper wall portions；
Fig. 4 is the sectional view of the sample cell according to further embodiment of the present invention；
Fig. 4 A be the sample cell shown in Fig. 4 seal lid be inserted into body when, the sectional view of its upper wall portions；
Fig. 4 B is the sectional view of the alternate embodiment sealing cap；
Fig. 5 is the sectional view of sample cell bar according to an embodiment of the invention；
Fig. 5 A is the enlarged drawing of the part A in Fig. 5；
Fig. 6 is the sectional view of porous plate assembly according to an embodiment of the invention；
Fig. 6 A is the enlarged drawing of the part B in Fig. 6；
Fig. 7 is the sectional view of pipettor tip member according to an embodiment of the invention.
Detailed description of the invention
With reference to shown in Fig. 1, illustrate the sample cell 100 of an one exemplary embodiment.Described sample cell 100 includes for containing
Put the hollow tube 102 of solid or liquid reagent.Described body 102 has closed bottom and the opening in its top edge portion
104, this opening 104 is limited by the upper wall portions 106 of substantially cylindrical.Sample cell 100 also includes sealing cap 110, this sealing
Cap 110 can be single and can disassemble from hollow tube 102, or can be connected to pipe by tethers alternatively
Body 102, this tethers preferably has resilient.
Seal cap 110 and include being generally formed into the component 112 of cylinder, for by the opening 104 of body removedly
Insert body 102, and engage with the upper wall portions 106 of body 102.In one embodiment as shown in fig. 1, it is generally formed into
Cylindrical component is cylindrical skirt part.The top edge of cylindrical skirt part is transverse wall 118, and this transverse wall 118 closes
One end of described cylindrical skirt part 112.In another embodiment, the component 112 being generally formed into cylinder can be substantially
For cylindrical solid core part (not shown), it can close body open 104.As it is shown in figure 1, in some embodiments
In, the component 112 being generally formed into cylinder can have outer containment layer 114, and this sealant 114 is interior with upper wall portions 106
Side face is in sealing contact to provide tight seal, and preferably Fluid Sealing.Sealant 114 can be crossed over and be generally formed into cylinder
The whole face of cylinder of component 112, or can be axially to cover the one of the face of cylinder being generally formed into cylindrical member 112
Part, but it is around the whole circumference of this upper wall portions.
Sample cell 100 farther includes the adsorption layer 116 that the opening 104 around body 102 is installed, for example, adsorption layer 116
The outer peripheral face of upper wall portions 106 can be attached to.Adsorption layer 116 around body open 104, whole preferably about upper wall portions 106
Individual circumference, with adsorption sample leakage, such as, from aerosol or the liquid of body 102 leakage.Adsorption layer 116 can include by porous
The porous carrier that material (such as sponge, non-woven fabrics or filter element material etc.) forms, this porous carrier occupy around
The main space of opening 104, and define the foraminate supporting construction of tool.Adsorption layer 116 also includes interspersing among adsorption layer 116
Absorbability particle.Described absorbability particle can be attached to the supporting construction of porous carrier.Absorbability particle can be activated carbon
Particle, alumina particle etc..When sample leaks from body 102 in aerosol form due to the poor sealing of body open 104
When, it is by process or near the sealant 116 around body 104 opening.Absorbability particle in this sealant 116 can be subsequently
Organism-absorbing molecule (such as, other similar materials in protein, nucleic acid, microorganism or aerosol leakage), and be fixed in
In adsorption layer 116.Like this, space outerpace can not be leaked into further from the aerosol of sample cell 100 leakage and pollute experiment
Environment.
In a particular embodiment, adsorption layer 116 can be adhered to the outer peripheral face of upper wall portions 106 with adhesive.Specifically in fact
Executing in example, adsorption layer 116 can be removably mounted on the outer peripheral face of upper wall portions 106.For example, adsorption layer 116 can be by advance
Being configured to cylindrical skirt part or ring, its diameter is slightly less than the external diameter at opening 104 for the upper wall portions 106.When adsorption layer 116 is mounted
When the outer peripheral face of upper wall portions 106, it will slightly expand to be adapted to the outer peripheral face of upper wall portions 106.Like this, adsorption layer 116
Can just be installed in the outer peripheral face of upper wall portions 106 by any adhesive.
With reference to shown in Fig. 2, illustrate another exemplary sample cell 200.Sample cell 200 include for hold solid or
The hollow tube 202 of liquid reagent.Body 202 has closed bottom and the opening 204 in its top edge portion, opening 204
Limited by the upper wall portions 206 of substantially cylindrical.Sample cell 200 also includes sealing cap 210, and this sealing cap 210 has substantially
Being formed as cylindrical component 212, it can be single for sealing cap 210, and can disassemble from hollow tube 202.
Sample cell 200 includes the outer shoulder 222 adjacent with the opening 204 of upper wall portions 206.For example, outer shoulder 222 can be away from
Leave mouth 204 several millimeters (such as, the 1st, the 2nd, the 3rd, 5 or 10 millimeters).Seal cap 210 and can be connected to body by tethers 220
210, tethers preferably has resilient.In an embodiment as shown in Figure 2, tethers 220 can have be connected to seal
First end of the marginal portion of cap 210, and it is connected to outer shoulder 222 and second end relative with the first end.
Sample cell 200 farther includes to invest the outer peripheral face of upper wall portions 206 adsorption layer 216 around body open 204.
Adsorption layer 216 is around body open 204, is preferably the whole circumference around upper wall portions 206, lets out from body 202 to absorb
The sample of leakage.Adsorption layer 216 can extend between opening 204 and outer shoulder 222.In one embodiment, adsorption layer 216 can
To be attached to the outer peripheral face of upper wall portions 206.In another embodiment, adsorption layer 216 can be removably mounted on upper wall portions
The outer peripheral face of 206.For example, adsorption layer 216 can be cylindrical skirt part or ring by pre-structured, and it is at relaxation device and does not appoint
Diameter during what external force is slightly less than the external diameter of body open 204.Owing to the porous carrier of adsorption layer 216 is likely to be of some bullets
Property, therefore when adsorption layer 216 is installed in the outer peripheral face of upper wall portions 206, adsorption layer 216 slightly expands, thus to extend shape
State adapts to the outer peripheral face of upper wall portions 206.Like this, adsorption layer 216 can any adhesive and be fixed in upper wall
The outer peripheral face in portion 206.Outer shoulder 222 can be any shape, for example flat or coning inclined-plane, if itself and adsorption layer
The lower end of 216 engages thinks that adsorption layer 216 provides some to support, and stops adsorption layer 216 along body 202 axially-movable,
Especially move downward.Owing to adsorption layer 216 is along the sealing cap 210 of the engaged body open 204 that upwards moves of body 202
Being limited, therefore adsorption layer 216 can be fixed between sealing cap 210 and outer shoulder 222, it is to avoid form liquid or aerosol is let out
Gap that leakage may be passed through or slit.
Adsorption layer 216 can include being made up of porous material (such as sponge, non-woven fabrics or filter element material etc.)
Porous carrier, this porous carrier occupies the main space around opening 204, and defines the foraminate supporting construction of tool.
Adsorption layer 216 also includes the absorbability particle interspersing among adsorption layer 216.Absorbability particle can be activated carbon granule, aluminum oxide
Particle etc..
With reference to shown in Fig. 3, illustrate another exemplary sample cell 300.Described sample cell 300 includes for holding solid
The hollow tube 302 of body or liquid reagent.Body 302 has closed bottom and the opening 304 in its top edge portion, opening
304 are limited by the upper wall portions 306 of substantially cylindrical.Sample cell 300 also includes sealing cap 310, and this sealing cap 310 has greatly
Causing to be formed as cylindrical component 312, it is for inserting body 302 by body open 304 removedly, and sealing cap 310 can
Being single, and can disassemble from hollow tube 302.
Seal the adsorption layer that cap 310 farther includes to be coaxially disposed with the component 312 being generally formed into cylinder
316.Adsorption layer 316 is attached to seal cap 310, for example, invests the one end of the component 312 being generally formed into cylinder described in Guan Bi
To cross wall 318.Adsorption layer can be also generally formed into cylinder, and has the component being generally formed into cylinder
The internal diameter of the external diameter of 312.As shown in Figure 3A, be generally formed into cylinder component 312 and adsorption layer 316 between can form circle
Cylindrical gap 324, so that when sealing cap 310 and closing body open 304, the upper wall portions 306 of body 302 can be placed
In being generally formed between cylindrical member 312 and adsorption layer 316.Like this, adsorption layer 316 can engage upper wall portions 306
Outer peripheral face, with absorption from hollow tube 302 leakage sample.
In a particular embodiment, seal cap 310 to farther include to be arranged at the supporting layer 317 outside adsorption layer 316.?
Support layer 317 can be formed cylindrical skirt part.Adsorption layer 316 can be attached to the inner surface of supporting layer 317, so that
Adsorption layer 316 can supported layer 317 support.
Supporting layer 317 is typically used to provide support to keep shape and rigidity.In certain embodiments, supporting layer 317 has
Have more than about 20 shore D or more than the hardness of about 30 shore D, test D 2240 canonical measure according to ASTM.At some
In embodiment, supporting layer has the hardness between from about 30 shore D to about 90 shore D, marks according to ASTM test D 2240
Locating tab assembly.In certain embodiments, supporting layer has at least 20%, or at least 30% compressive deformation.For forming support
The example of the polymeric material of layer includes but is not limited to, polypropylene (PP), Merlon (PC), polyvinyl chloride (PVC), propylene
Nitrile-butadiene-styrene (ABS), and polystyrene (PS).
With reference to shown in Fig. 4, illustrate another exemplary sample cell 400.Sample cell 400 include for hold solid or
The hollow tube 402 of liquid reagent.Body 402 has closed bottom and the opening 404 in its top edge portion, opening 404
Limited by the upper wall portions 406 of substantially cylindrical.Sample cell 400 also includes sealing cap 410, and this sealing cap 410 has substantially
Being formed as cylindrical component 412, it is for inserting body 402 by body open 404 removedly.It is generally formed into cylinder
The component 412 of shape is skirt.Therefore be generally formed into cylinder component 412 outside the outer peripheral face of upper wall portions 406, for example,
Contact with outer peripheral face, or slightly separate with described outer peripheral face but have in-between some inserts (such as, seal and/or inhale
Attached insert).
Seal cap 410 have be attached to be generally formed into cylinder component 412 and by be generally formed into cylinder
The adsorption layer 416 that component 412 is coaxially disposed.As shown in Figure 4 A, when sealing cap 410 engages hollow tube 402 to close opening
When 404, sealant 416 can be around the upper wall portions 406 of body 402.For example, adsorption layer 416 extends opening 404 and upper wall portions
On outer shoulder between.In a particular embodiment, adsorption layer 416 be partially extended to opening 404 and upper wall portions outer shoulder it
Between.
The alternate embodiment of the sealing cap shown in Fig. 4 B show Fig. 4 A.As shown in Figure 4 B, seal cap to farther include
Invest the inner surface being generally formed into cylindrical member 412 and the sealant 419a on adsorption layer 416a.When sealing cap 410
When engaging hollow tube 402 to close opening, sealant 419a is in sealing contact and around opening with the outer peripheral face of upper wall portions 406.
It provides tight seal between sealing cap and upper wall portions 406.Additionally, be located slightly away from upper wall portions relative to sealant 419a
The adsorption layer 416a of the opening of 406 can adsorption sample leak, such as from liquid or the aerosol of body open leakage.Like this,
Sample leakage can be avoided greatly, and reduces the pollution to environment.
According to the measurement of ASTM D395 method B, sealant can have the compressive deformation less than about 30%, preferably little
It in 20%, is more preferably less than 10%, is most preferably less than 5%.Test D 2240 canonical measure, sealant according to ASTM
Can have the hardness between from about 30 shore D to about 90 shore D, preferably from about 35 shore D to about 80 shore D
Between hardness, from about 40 shore D to about 75 or 80 shore D between hardness, from about 40 shore D to about 70 shore
Hardness between D, preferred from about 40 shore D to the hardness of about 50 or about 60 shore D.Can be used for forming sealant
The example of polymeric material include but is not limited to, polyethylene (PE) (particularly low density polyethylene (LDPE) or LDPE), polyurethane
(PU), thermoplastic polyurethane (TPU), thermoplastic elastomer (TPE) (TPE), TPO (TPO), styrenic thermoplastic elastomer
(S-TPEs), thermoplastic elastomer (TPR), hydrogenated styrene-butadiene block copolymer (SEBS), TPV
(TPV), SBS (SBS), soft PVC (elPVC) etc..Preferably in fact
Executing in example, described sealant is made up of one or more in TPE, TPU and PVC, is preferably and is made up of TPE or TPU, or by
Both mixing compositions above-mentioned.
Preferably, for the polymeric material of sealant with for sealing other parts (except adsorption layer) and the body of cap
Polymeric material be chosen for so that two kinds of polymeric materials can interact under molding or bonding condition, from
And (retentively) is attached on supporting layer by conformally to make sealant.In a preferred embodiment, sealant by from TPE,
TPU and PVC combination in choose one or more polymeric materials composition, and seal cap other parts (except adsorption layer) and
Body is by polypropylene (PP), Merlon (PC), polyvinyl chloride (PVC), acrylonitrile-butadiene-styrene (ABS) (ABS), Yi Jiju
One or more polymer composition in styrene (PS) combination.
In the embodiment of various sample cells, body is generally of to connect and substantially becomes cylindrical upper wall portions as above
Lower wall portion.In certain embodiments, lower wall portion can be taper into the angle between about 10 degree to about 20 degree or
Thin-walled portion coning, to form bottom the closed circle of body.In a preferred embodiment, sample cell assembly is especially suitable
For PCR (such as PCR), and the wall thickness of body can be about 0.008 to about 0.015 inch.Lower wall portion
Can be thinner, wall thickness is of about 0.008 to about 0.012 inch, and upper wall portions can be thicker, and wall thickness is of about 0.010 to greatly
About 0.015 inch.
In a preferred embodiment, the volume that sample cell has be enough to hold from 50 microlitres to the liquid less than 1 milliliter, excellent
Elect the liquid of about 0.5 milliliter as.
In a preferred embodiment, the total measurement (volume) that sample cell has is for from about 0. milliliter l to about 2.0 milliliter.Excellent
In the embodiment of choosing, all materials for sample cell assembly are heat-resisting, and can withstand up to the high temperature of 100 DEG C.
The sample cell of various embodiments all can be applied to sample cell bar or have the porous plate of industry standard specifications
(i.e. 36-, 48-, 96-, 192-, 384-hole PCR plate) etc..Essentially, in sample cell bar, multiple (such as the 4th, 8 or 12
Individual) hollow tube described in certain embodiment above-mentioned is arranged symmetrically by linear array, thus their axis is mutual
Parallel.Adjacent in these bodys two can connect optionally by band.
Fig. 5 illustrates the sample cell bar 500 according to an exemplary embodiment.Additionally, sample cell bar 500 also includes multiple
(the 4th, 8 or 12) are arranged into the sealing cap of linear array in this embodiment.And any two is adjacent in multiple sealing caps
Component is connected by tethers.In the particular embodiment, each tethers can have and is connected to two adjacent tubes
The two ends of outer shoulder.The upper wall portions of each of multiple sealing caps engaging tubular bodies removedly.Fig. 5 A is the putting of part A in Fig. 5
Big figure, illustrates the upper wall portions of body, and this body has the adsorption layer of the opening installation around body, and this adsorption layer is attached to
The outer peripheral face in wall portion.
Similarly, in a multi-well microtiter plate, with one of them in above-described embodiment, there is same design
Multiple (such as the 36th, the 48th, the 96th, 192 or 384) hollow tube is arranged into the shape of porous plate according to the canonical form of industrial circle
Formula.For example, 96-hole microtiter plate is a width of 3 and 5/8 inches, the disk body of a length of 5 inches, and it includes 96 identical samples
Hole, in the rectangular array in 8*12 hole.Therefore, each hole of the microtiter plate of the present invention has and the enforcement of above-mentioned sample cell assembly
The identical design of the body of one of them of example.
Fig. 6 illustrates the exemplary embodiment of a 96-orifice plate 600, and each of which hole is respectively provided with the pipe being similar to shown in Fig. 2
The design of body.Fig. 6 A is the zoomed-in view of part B in Fig. 6.As shown in Figure 6A, plate body includes the support wherein with multiple hole
Piece, closed bottom and the sidewall extending between opening and closed bottom.Wherein each hole is respectively provided with opening, and each Kong Jun
Having the upper wall portions of substantially cylindrical, this upper wall portions limits opening in its marginal portion, and at least in part from support chip
Upwardly extend.Each hole is respectively provided with the adsorption layer of the opening installation around this hole.Adsorption layer is attached to the outer surface of upper wall portions.This
Outward, this plate also includes multiple (the 4th, the 8th, the 12nd, 96) corresponding sealing cap being arranged as array in identical embodiment, and many
Two components of arbitrary neighborhood in individual sealing cap pass through tethers or piece connects.These seal cap and are arranged so that their axis
It is parallel to each other.Each in multiple sealing caps engages the upper wall portions in hole removedly.
Each hole shown in Fig. 5 and 6 and corresponding sealing cap thereof are respectively provided with and Fig. 1,3 similar with the sample cell shown in 4
Design.In this case, the adsorption layer in the hole of 96 orifice plates 600 can adsorb the sample from hole leakage, thus avoid or at least subtract
Cross pollution between few different hole.
With reference to shown in Fig. 7, illustrate the exemplary embodiment of pipettor tip member 700.This pipettor tip member 700
It is used for mating pipettor body transfer liquid separatably.Pipettor tip member 700 includes being used for for pipettor pipe
Body is axially inserted into bigger proximal openings the 702nd, upper wall portions the 704th, lower wall portion 706 of pipettor tip member, and is used for inhaling
Take and distribute the distal openings 708 of liquid.Upper wall portions 704 is adjacent with proximal openings 702.The far-end of pipettor body can pass through
Proximal openings 702 is inserted into elongated pipettor tip member 700 or is removed from elongated pipettor tip member 700.
Pipettor tip member farther includes to invest the filter element 710 of upper wall portions 704 inner peripheral surface, is used for stoping receiving
Sample in pipettor tip member 700 flows out via it, and filter element 710 includes by porous material (such as sponge, nonwoven
Cloth or filter element material etc.) porous carrier that forms, this porous carrier occupies the interior cross section of upper wall portions 704, and shape
Become the foraminate supporting construction of tool.Filter element 710 also includes the absorbability particle being distributed in.This absorbability particle can
To be activated carbon granule, alumina particle etc..When sample is inhaled into, by distal openings 708, the chamber being limited by lower wall portion 706
During body, some samples can be in aerosol form upwardly through filter element 710.Absorbability particle in filter element 710 can
Organism-absorbing molecule (such as, other similar materials in protein, nucleic acid, microorganism or aerosol leakage) subsequently, and consolidated
It is scheduled in filter element 710.Like this, the aerosol from pipettor tip member 700 leakage can not further move to be connect
The cavity being limited together in the upper wall portions 704 of pipettor body, thus decrease and pass through identical pipettor pipe between different sample
Body cross pollution.
In embodiment preferably, adsorption layer as shown in Figures 1 to 6 or filter element as shown in Figure 7 can be by
Be combined with porous carrier with infiltration, coating, sintering, spraying or other suitable methods.In a particular embodiment, some filter material
The filter element etc. that material is made up of polyethylene, can be carbonized to form active charcoal particle by heating in a vacuum
It is distributed in porous carrier therein.In some other embodiment, absorbability particle such as alumina particle is sprayed-on or splash
To form the porous carrier with alumina particle in filter element, sponge or non-woven fabrics.There is the porous of absorbability particle
The shape and size of carrier can be arranged to subsequently be applicable to be installed to as adsorption layer the upper wall portions of body or seal on cap,
Or it is installed in the inner chamber of pipettor tip member as filter element.
In certain embodiments, adsorption layer as shown in Figures 1 to 6 or filter element as shown in Figure 7 can include by
Its weight accounting is the absorbability particle between 35% to 55%, such as weight accounting be the 40%th, the 45%th, 50% adsorptivity
Grain.Porous carrier provides the good supporting construction that can fix absorbability particle, thus extends making of absorbability particle
With.It is used as adsorption layer or the material of filter element also can be used for other application.In certain embodiments, this material is permissible
Being formed mat or cloth, they can be placed on and leak from test tube or other containers with absorption on testing stand or laboratory table
Fluid sample.Absorbability particle in described material can effectively reduce the pollution being caused by sample leakage.
With patent application, all disclosures mentioned in this specification show that those skilled in the art is related for the present invention
Human-subject test.All disclosures and patent application in this by being incorporated herein by reference with reference to same content, just
As each disclosure or patent application are pointed out specifically and respectively to be incorporated to by reference.Described disclosure and patent
The description of application does not needs to constitute the prior art recognizing that they are the application.
Although for the purpose being more clearly understood that, aforesaid invention is described in detail by example and example, can
Implement with the scope that clear, certain change and change can allow in the application.
Claims (29)
1. a sample cell, it is characterised in that include:
Having the hollow tube of the upper wall portions of substantially cylindrical, described upper wall portions limits described hollow tube in its marginal portion
Opening；
There is the sealing cap of the component being generally formed into cylinder, when described sealing cap engages with described hollow tube to close
When stating opening, the described component being generally formed into cylinder is in sealing contact with the inner peripheral surface of described upper wall portions；And
The adsorption layer installed around the described opening of described hollow tube, described adsorption layer is let out from described hollow tube in order to adsorb
The sample of leakage.
2. sample cell according to claim 1, it is characterised in that described adsorption layer is attached to the periphery of described upper wall portions
Face.
3. sample cell according to claim 2, it is characterised in that described hollow tube includes the opening with described upper wall portions
Adjacent outer shoulder, described adsorption layer extends between described opening and described outer shoulder.
4. a sample cell, it is characterised in that include:
Having the hollow tube of the upper wall portions of substantially cylindrical, described upper wall portions limits described hollow tube in its marginal portion
Opening；
There is the sealing cap of component being generally formed into cylinder, open described in closing when described sealing cap engages with hollow tube
During mouth, the described component being generally formed into cylinder becomes to be in sealing contact with the inner peripheral surface of described upper wall portions；And
Invest the adsorption layer of described sealing cap, when described sealing cap engages with described hollow tube to close described opening, institute
State adsorption layer around described upper wall portions to adsorb the sample from hollow tube leakage.
5. sample cell according to claim 4, it is characterised in that described adsorption layer is generally formed into cylinder with described
Component coaxial ground arrange so that when described sealing cap engage with described hollow tube to close described opening when, described
Upper wall portions is generally formed between cylindrical component and described adsorption layer described in being arranged at.
6. sample cell according to claim 5, it is characterised in that described sealing cap also includes being arranged at described adsorption layer
Outside and for supporting the supporting layer of described adsorption layer.
7. a sample cell, it is characterised in that include:
Having the hollow tube of the upper wall portions of substantially cylindrical, described upper wall portions limits described hollow tube in its marginal portion
Opening；
Having the sealing cap of the component being generally formed into cylinder, the described component being generally formed into cylinder is skirt, and
When described sealing cap engages with described hollow tube to close described opening, the described component being generally formed into cylinder is in institute
State outside the outer peripheral face of upper wall portions；And
Being generally formed into the adsorption layer of the inner surface of the component of cylinder described in investing, described adsorption layer is substantially formed with described
Arrange for cylindrical component coaxial, thus when described sealing cap engages with described hollow tube to close described opening,
Described adsorption layer around described hollow tube upper wall portions with adsorb from described hollow tube leakage sample.
8. sample cell according to claim 7, it is characterised in that described sealing cap also include investing described in be generally formed into
The sealant of the inner surface of cylindrical component, and described sealant is arranged on described adsorption layer, and when described
When sealing cap engages with described hollow tube to close described opening, described sealant connects with the outer peripheral face sealing of described upper wall portions
Touch and around described opening.
9. a sample cell bar, it is characterised in that include:
Multiple hollow tubes, each described hollow tube is respectively provided with the upper wall portions of substantially cylindrical, the plurality of hollow tube
Linear array is arranged symmetrically, thus their axis is parallel to each other, and described upper wall portions is in the restriction of its marginal portion is described
The opening of blank pipe body；And
The linear array that multiple sealing caps are constituted, each sealing cap is in sealing contact with one of the plurality of hollow tube, and
And the plurality of sealing cap in any two adjacent members connected by tethers；
Wherein each hollow tube all includes the adsorption layer that the opening around described hollow tube is installed, and described adsorption layer is in order to inhale
The sample of described hollow tube of chiming in leakage.
10. sample cell bar according to claim 9, it is characterised in that described adsorption layer is attached to outside described upper wall portions
Side face.
11. sample cell bars according to claim 10, it is characterised in that described hollow tube includes and described upper wall portions
The adjacent outer shoulder of opening, and described adsorption layer extends between described opening and outer shoulder.
12. 1 kinds of sample cell bars, it is characterised in that include:
Multiple hollow tubes, each hollow tube is respectively provided with the upper wall portions of substantially cylindrical, and the plurality of hollow tube becomes line
Property array arrange symmetrically, thus their axis is parallel to each other, and described upper wall portions limits described hollow tube in its marginal portion
The opening of body；And
The linear array that multiple sealing caps are constituted, each sealing cap is in sealing contact with one of the plurality of hollow tube, and
And the plurality of sealing cap in any two adjacent members connected by tethers；
Each seals cap and is respectively provided with the component being generally formed into cylinder, when described sealing cap engages with described hollow tube to close
When closing described opening, the described component being generally formed into cylinder is in sealing contact with the inner peripheral surface of described upper wall portions；And
Each seals cap and is respectively provided with adsorption layer, when described sealing cap engages with described hollow tube to close described opening, and institute
State adsorption layer around described upper wall portions to adsorb the sample from the leakage of described hollow tube.
13. sample cell bars according to claim 12, it is characterised in that described adsorption layer is generally formed into circle with described
The component coaxial ground of cylindricality is arranged, so that when described sealing cap engages with described hollow tube to close described opening,
Described upper wall portions is generally formed between cylindrical component and described adsorption layer described in being arranged at.
14. sample cell bars according to claim 13, it is characterised in that described sealing cap also includes being arranged at described suction
Outside attached layer and for supporting the supporting layer of described adsorption layer.
15. 1 kinds of sample cell bars, it is characterised in that include:
Multiple hollow tubes, wherein each hollow tube is respectively provided with the upper wall portions of substantially cylindrical, the plurality of hollow tube
Linear array is arranged symmetrically, thus their axis is parallel to each other, and described upper wall portions is in the restriction of its marginal portion is described
The opening of blank pipe body；And
The linear array that multiple sealing caps are constituted, each sealing cap is in sealing contact with one of the plurality of hollow tube, and
And the plurality of sealing cap in any two adjacent members connected by tethers；
Each seals cap and is respectively provided with the component being generally formed into cylinder, which is skirt, when described sealing cap and described hollow tube
When body engages to close described opening, the described component being generally formed into cylinder is outside the outer peripheral face of described upper wall portions；With
And
Each seal cap be respectively provided with invest described in be generally formed into the adsorption layer of inner surface of component of cylinder, and described suction
Attached layer is arranged with described with being generally formed into cylindrical component coaxial, thus when described sealing cap connects with described hollow tube
When closing to close described opening, described adsorption layer, around the upper wall portions of described hollow tube, is let out from described hollow tube with absorption
The sample of leakage.
16. sample cell bars according to claim 15, it is characterised in that described sealing cap also include investing described in substantially shape
Become the sealant of the inner surface of cylindrical component, and described sealant is arranged on described adsorption layer, and work as
When described sealing cap engages with described hollow tube to close described opening, described sealant is close with the outer peripheral face of described upper wall portions
Sealing-in is touched and around described opening.
17. 1 kinds of porous plate assemblies, it is characterised in that include:
Having the plate body of support chip, described support chip has the multiple holes being located therein, and each hole is respectively provided with opening, closed bottom
And extending sidewall between both, at least one in wherein said multiple holes has the upper wall of substantially cylindrical
Portion, described upper wall portions limits described opening, and upwardly extends from described support chip at least in part in its marginal portion；
Wherein each hole is respectively provided with the adsorption layer of the outer surface investing described upper wall portions and opening around described hole, with absorption
Sample from the leakage of described hole.
18. porous plate assemblies according to claim 17, it is characterised in that described adsorption layer is described opening and described
Extend between blade.
19. 1 kinds of porous plate assemblies, it is characterised in that include:
Having the plate body of support chip, described support chip has the multiple holes being located therein, and each hole is respectively provided with opening, closed bottom
And extending sidewall between both, at least one in wherein said multiple holes has the upper wall of substantially cylindrical
Portion, described upper wall portions limits described opening, and upwardly extends from described support chip at least in part in its marginal portion；
The array that multiple sealing caps are constituted, wherein each sealing cap is in sealing contact with one of the plurality of hole, the plurality of
Seal cap and connected together by connecting piece；
Each seals cap and is respectively provided with the component being generally formed into cylinder, when described sealing cap engages to close described with described hole
During opening, the described component being generally formed into cylinder is in sealing contact with the inner peripheral surface of described upper wall portions；And
Each seals cap and is respectively provided with adsorption layer, when described sealing cap engages with described hole to close described opening, and described absorption
Layer around substantially cylindrical upper wall portions with adsorb from described hole leakage sample.
20. porous plate assemblies according to claim 19, it is characterised in that described adsorption layer is generally formed into described
Cylindrical component coaxial ground is arranged, so that when described sealing cap engages with described hole to close described opening, described
Upper wall portions is generally formed between cylindrical component and described adsorption layer described in being arranged at.
21. porous plate assemblies according to claim 20, it is characterised in that described sealing cap farther includes to be arranged at
Outside described adsorption layer and for supporting the supporting layer of described adsorption layer.
22. 1 kinds of porous plate assemblies, it is characterised in that include:
Having the plate body of support chip, described support chip has the multiple holes being located therein, and each hole is respectively provided with opening, closed bottom
And extend sidewall between both, at least one of wherein said multiple holes has the upper wall portions of substantially cylindrical,
Described upper wall portions limits described opening in its marginal portion, and upwardly extends from described support chip at least in part；
The array that multiple sealing caps are constituted, wherein each sealing cap is in sealing contact with one of the plurality of hole, the plurality of
Seal cap and connected together by connecting piece；
Each seals cap and is respectively provided with the component being generally formed into cylinder, which is skirt, when described sealing cap engages with described hole
During to close described opening, the described outer peripheral face being generally formed into the upper wall portions in described substantially cylindrical for the cylindrical component
Outside；
Each seal cap be respectively provided with invest described in be generally formed into the adsorption layer of inner surface of component of cylinder, and described suction
Attached layer by be generally formed into cylinder component coaxial arrange, thus when described sealing cap engage with described hole to seal
When stating opening, the upper wall portions of the substantially cylindrical around described hole for the described adsorption layer is to adsorb the sample from the leakage of described hole.
23. porous plate assemblies according to claim 22, it is characterised in that described sealing cap farther includes to invest described
It is generally formed into the sealant of the inner surface of the component of cylinder, and described sealant is arranged on described adsorption layer,
And when described sealing cap engages with described hole to close described opening, described sealant is close with the outer peripheral face of described upper wall portions
Sealing-in is touched and around described opening.
24. sample cells according to any one of claim 1 to 8, the sample according to according to any one of claim 9 to 16
QC bar, or the porous plate assembly according to according to any one of claim 17 to 23, it is characterised in that described adsorption layer bag
Include the porous carrier being wherein scattered with absorbability particle.
25. sample cells according to any one of claim 1 to 8, the sample according to according to any one of claim 9 to 16
QC bar, or the porous plate assembly according to according to any one of claim 17 to 23, it is characterised in that described porous carrier
Including sponge, non-woven fabrics or filter element.
26. sample cells according to any one of claim 1 to 8, the sample according to according to any one of claim 9 to 16
QC bar, or the porous plate assembly according to according to any one of claim 17 to 23, it is characterised in that described adsorbent
Grain includes activated carbon granule and/or alumina particle.
27. 1 kinds of pipettor tip member, this pipettor tip member is for mating pipettor body separatably and shifting liquid
Body, and described pipettor tip member has elongated tubular container, it is characterised in that and described tubular container includes:
For receiving the proximal openings of pipettor body；
For the distal tip opening from pipettor tip member distribution liquid；And
The upper wall portions adjacent with described proximal openings, for engaging with described pipettor body removedly；And
Invest the filter element of described upper wall portions inner peripheral surface, for avoiding the sample warp being contained in described pipettor tip member
Being flowed out by it, wherein said filter element includes the porous carrier being wherein scattered with absorbability particle.
28. pipettor tip member according to claim 27, it is characterised in that described porous carrier includes sponge or nothing
Spin cloth.
29. pipettor tip member according to claim 27, it is characterised in that described absorbent particles includes activated carbon
Particle and/or alumina particle.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310639182 | 2013-12-04 | ||
| CN2013106391822 | 2013-12-04 | ||
| PCT/CN2014/093033 WO2015081872A1 (en) | 2013-12-04 | 2014-12-04 | Sample tube assemblies and pipette tip with improved leakage prevention |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106103686A true CN106103686A (en) | 2016-11-09 |
Family
ID=53272901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480066330.9A Pending CN106103686A (en) | 2013-12-04 | 2014-12-04 | There is the sample cell assembly that improved leakage is taken precautions against |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106103686A (en) |
| WO (1) | WO2015081872A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109439511A (en) * | 2018-11-14 | 2019-03-08 | 广东佛润斯科生物科技有限公司 | A kind of biological material extraction element |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108728339A (en) * | 2018-05-31 | 2018-11-02 | 浙江懿康医疗科技有限公司 | A kind of higher PCR single tubes of strength of stability |
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| US4748859A (en) * | 1987-03-06 | 1988-06-07 | Rainin Instrument Co., Inc. | Disposable pipette tip |
| CN1693151A (en) * | 2004-05-08 | 2005-11-09 | 陈格 | Apparatus for drying preserving and recovering of liquid sample |
| CN201603564U (en) * | 2010-01-15 | 2010-10-13 | 袁建华 | Plug core disposable transfer pipette |
| CN202638452U (en) * | 2012-06-08 | 2013-01-02 | 惠州鸿雨科技有限公司 | Centrifugal tube |
| CN202730124U (en) * | 2012-07-24 | 2013-02-13 | 杭州金源生物技术有限公司 | Sealed sample tube |
| CN203307336U (en) * | 2013-06-03 | 2013-11-27 | 杭州金源生物技术有限公司 | PCR (Polymerase Chain Reaction) tube |
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2014
- 2014-12-04 WO PCT/CN2014/093033 patent/WO2015081872A1/en active Application Filing
- 2014-12-04 CN CN201480066330.9A patent/CN106103686A/en active Pending
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|---|---|---|---|---|
| US4748859A (en) * | 1987-03-06 | 1988-06-07 | Rainin Instrument Co., Inc. | Disposable pipette tip |
| CN1693151A (en) * | 2004-05-08 | 2005-11-09 | 陈格 | Apparatus for drying preserving and recovering of liquid sample |
| CN201603564U (en) * | 2010-01-15 | 2010-10-13 | 袁建华 | Plug core disposable transfer pipette |
| CN202638452U (en) * | 2012-06-08 | 2013-01-02 | 惠州鸿雨科技有限公司 | Centrifugal tube |
| CN202730124U (en) * | 2012-07-24 | 2013-02-13 | 杭州金源生物技术有限公司 | Sealed sample tube |
| CN203307336U (en) * | 2013-06-03 | 2013-11-27 | 杭州金源生物技术有限公司 | PCR (Polymerase Chain Reaction) tube |
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| CN109439511A (en) * | 2018-11-14 | 2019-03-08 | 广东佛润斯科生物科技有限公司 | A kind of biological material extraction element |
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| Publication number | Publication date |
|---|---|
| WO2015081872A1 (en) | 2015-06-11 |
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Application publication date: 20161109 |