CN101398437A - Liquid transfering device, liquid transfering tube used in the device and series containers - Google Patents
Liquid transfering device, liquid transfering tube used in the device and series containers Download PDFInfo
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- CN101398437A CN101398437A CNA2007100467502A CN200710046750A CN101398437A CN 101398437 A CN101398437 A CN 101398437A CN A2007100467502 A CNA2007100467502 A CN A2007100467502A CN 200710046750 A CN200710046750 A CN 200710046750A CN 101398437 A CN101398437 A CN 101398437A
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Abstract
The invention discloses a liquor relieving device as well as a pipette and a series vessel used in the liquor relieving device. The invention particularly discloses a device for biochemical operations, comprising a pipette and a taper-shaped object which is provided with a hollow interior and extends along the axial direction. The pipette is provided with a first tail end and a second tail end, wherein, the first tail end is equipped with an opening while the second tail end is provided with a hermetic type volume-changeable gasbag. In virtue of the changes of the volume, a pressure difference is produced inside the hermetic type gasbag, thus realizing the release and suction of reagents in the pipette. The liquor relieving device also comprises a series vessel formed by connecting a flat slab part with a plurality of cells. The series vessel is pre-filled with various reagents in sequence needed by corresponding biochemical operations and is provided with a locking part. The liquor relieving device is also composed of an action control mechanism, a robot arm and a chassis; the chassis is provided with at least one groove which is equipped with at least one embedding part. The series vessel is fixed on the chassis through the mutual locking and clamping between the closing part and the embedding part in the groove of the chassis.
Description
Technical field
The invention relates to a kind of liquid-transfering device, particularly relevant for a kind of reagent that utilizes a transfer pipet to be used in combination and to be pre-charged with in the container of a series of many nests of formula chamber, to carry out the robotization micropipette device of nucleic acid purification, extraction, separation or screening.
Background technology
Along with human genome, function group are constantly furtherd investigate, life science is got over the convergence maturation for the biological research and development technology of large-scale molecular, for example: nucleic acid, protein, ferment etc., and the biological sample mixture of various components often, its composition complexity very, existing technology is to utilize to separate, extract or heating, comes from blood, cell ... carry out screening again in the sample after the purifying.
Because the technology of nucleic acid purification is ripe gradually, its operation steps in response to purge process has the sample of arrangement, adds damping fluid, mixes magnetic bead, cocktail buffer and magnetic bead, magnetic resolution, add damping fluid, heating, extraction purifying thing or the like once more.Program standardization based on nucleic acid purification, its needed relatively detectable also can be in advance in regular turn filling needle to the supporting volume production of the needed different reagent of different nucleic acid purifications, and prior art subject matter can be distinguished into three parts and does explanation: the absorption that how accurately to be controlled at reagent solution amount in the transfer pipet, discharge, move etc., because of existing liquid shifting equipment is to utilize the piston position that changes transfer pipet inside to reach in the cavity, outside atmospheric pressure is poor, also must to be used and move liquid head (Tip) as the fluid storage cavity, just can reach absorption to reagent, move, with mix, its reusable piston type moves the liquid head to carry out moving in the liquid process of different samples at sample and is easy to generate cross pollution, move the piston ring that is provided with in the liquid head collocation transfer pipet again and need periodic replacement, shortcomings such as maintenance, and come the means of storaging liquid as mobile reagent by using piston type to move liquid head collocation transfer pipet, in order to reach the accurate control that moves liquid measure, and the shortcoming that has augmented complicated structural design and be unfavorable for the convenience operation, expended the time in large quantities, cost such as manpower and job procedure has necessity of its improvement really; And carry out the part of magnetic resolution at nucleic acid purification, existing technology is to utilize a hollow bar magnet cover, this bar magnet cover can provide a ccontaining magnetic part, bar magnet cover in conjunction with magnetic part stretches in the kit that is pre-charged with reagent again, to carry out magnetic resolution, but its shortcoming is that the bar magnet cover at every turn can only be from the magnetic bead of cutting out partial in the kit of filling reagent, therefore this magnetosheath rod repetitiousness must be goed deep into carrying out in the kit magnetic resolution, up to obtaining the extract sample, this not convenient magnetic resolution process, the input that needs costs such as over head time and job procedure further has necessity of its improvement; Moreover, conveniently remove glued membrane in the existing envelope film processing procedure in order to detect in the future, not tight really when therefore making the envelope film, cause the influence that kit is under pressure and make being pre-charged with reagent and leaking outside in the air transport process, run off again or because seal the volatile liquid that does not closely cause being pre-charged with in the kit of film, or it is too tight to make the envelope film, causes when the removal glued membrane application of force excessive, makes the spilling or spill and leakage of kit content.
Disclose a kind of assembly of isolating nucleic acid among the Korean Patent KR10-0445560, it has the separate type cylindrical container circular lid relative with, be provided with several nest chambers in this container, its corresponding circular lid is provided with the teat of internal diameter, this internal diameter provides magnetism stick one to insert the space, during for nucleic acid purification must through magnetic separation step, be pre-charged with after damping fluid or the ferment and this nest is indoor, again with the envelope film to give sealing.When using the prior art, be directly to poke the sealing envelope film that covers on the nest chamber, to carry out purification step by the teat on the circular lid in purification step; This prior art problems is, after transportation, there are high chance to be infected with to obscure purifying purity result's pollution product on the outer encapsulated membranes surface of nest chamber, or, experience multiple tracks formality in the process of carrying, opening, then also there is very big chance that the pollutants such as scurf, blood, sweat of human body or animal are attached on the surface of envelope film, when teat is directly poked the envelope film that covers on the nest chamber, also can in the lump pollutant be infected with in the damping fluid, and destroyed the purity of final output object.
Above-mentioned existing liquor-transferring system all has its defective, therefore be necessary to do further improvement, so that a kind of cross-infection of being caused because of transfer pipet can avoided to be provided, a kind of envelope film device that but easily removes that closes is provided again simultaneously, the surface contaminants of avoiding sealing film has polluted the purity of last check achievement, to overcome the shortcoming of prior art.
Description of drawings
Fig. 1 is the structure front elevation according to liquid-transfering device of the present invention.
Fig. 2 is the structure side view according to liquid-transfering device of the present invention.
Fig. 3 is the operation aspect structural representation according to liquid-transfering device of the present invention.
Fig. 4 is according to another operation aspect structural representation of liquid-transfering device of the present invention.
Fig. 5 A, Fig. 5 B are according to liquid-transfering device structure enlarged diagram of the present invention.
Fig. 6 A, Fig. 6 B are according to liquid-transfering device envelope membrane structure synoptic diagram of the present invention.
Fig. 7 A, Fig. 7 B are according to another structure enlarged diagram of liquid-transfering device of the present invention.
Fig. 8 is the structure illustrative view according to liquid-transfering device of the present invention.
Summary of the invention
The object of the present invention is to provide a kind of liquid-transfering device and be used in transfer pipet and series containers in this device, to guarantee in biochemical purification, extraction, screening or the testing process, the accurate control of reagent solution amount also can guarantee to isolate the external world and the issuable cross pollution of sample in the transfer pipet.
For reaching above-mentioned purpose or other purpose, the present invention adopts following technical scheme: a kind of liquid-transfering device includes: a transfer pipet, a series of container, an envelope film and an action control gear, wherein transfer pipet has the inside of hollow and is axially extended first terminal and second end, this first end is provided with an opening, and this second end has a closed elastic variable volume, when the stereomutation of this elastic variable volume, form pressure differential, and making this transfer pipet produce suction and release force, this transfer pipet is provided with at least one fixed part; Series containers is to connect several nest chambers by a flat part to constitute, and inserts in advance in regular turn in this series containers and carries out the corresponding required reagent of biochemical operation steps, and this series containers is provided with a buckling parts; The envelope film be provided with a glued membrane its in inserting the surface that reagent covers this flat part to this series containers fully; And the action control gear includes a mechanical arm and a chassis, this chassis has at least one groove, have at least one Embedded Division in the groove, utilize the buckling parts and the mutual snapping of Embedded Division that is arranged in the groove of chassis of this series containers, this series containers is fixed on this chassis.
For reaching above-mentioned purpose or other purpose, the present invention also adopts following technical scheme: a kind of transfer pipet is to be applied in the liquid-transfering device, this transfer pipet includes a transfer pipet, this transfer pipet has the inside of hollow and is positioned at first terminal and second end at axial two ends, this first end is provided with an opening, and this second end has a closed elastic variable volume, when the stereomutation of this elastic variable volume, form pressure differential, and making this transfer pipet produce suction and release force, this transfer pipet is provided with at least one fixed part.
For reaching above-mentioned purpose or other purpose, the present invention also adopts following technical scheme: a kind of series containers is to be applied in the liquid-transfering device, this series containers includes a series of containers and an envelope film, wherein series containers is to connect several nest chambers by a flat part to constitute, the indoor magnetic bead reaction nest chamber system with a special external form of several nests is arranged at an end of this series containers, this magnetic bead reaction bottom, nest chamber is a flat, has a side inclined-plane, it cooperates a magnetic element can carry out the magnetic resolution operation, also be about to this magnetic element near one of magnetic bead reaction nest chamber side inclined-plane, fixedly be adsorbed on this inclined-plane will be incorporated in the indoor magnetic bead of nest, and this transfer pipet can be goed deep into reagent after the indoor absorption magnetic resolution of nest.Again by being fixed on magnetic bead on the side inclined-plane, mobile transfer pipet is to this top, inclined-plane and discharge the reagent that is temporarily stored in the liquid storage chamber, draw reagent to bottom, nest chamber again, so reagent repetitiousness ground is washed away the magnetic bead that is adsorbed on the side inclined-plane, can obtain the higher extract sample of purity.
This series containers is provided with a buckling parts; And this envelope film is provided with a glued membrane, in this sequence container, insert in advance in regular turn in addition and carry out the corresponding required reagent of biochemical operation steps, it is provided with a hole in inserting the surperficial And that reagent covers glued membrane this flat part to this series containers fully in addition at this flat part, this hole can supply ccontaining one independent nest chamber, this independent nest chamber has a lid, it is the final product collection cups, so be arranged on the ora terminalis of this series containers, flat part surface near the final product collection cups is provided with a point, and this point and this flat part have a little difference in height distance.After filling required reagent or damping fluid, can be provided with surface and this point that a glued membrane covers this flat part, cover a plurality of nests chamber to seal fully, and pass through the setting of this point, can effectively will seal the film removal easily.
Compared to prior art, liquid-transfering device provided by the present invention and be used in transfer pipet and series containers in this device, comprise the disposable hollow taper transfer pipet of abandoning enclosure-type, exempted the problem that in moving the process of liquid, is easy to generate cross-infection, the droppable processing procedure of transfer pipet closed of the present invention has again overcome existing product complicated operations program fully, but still possesses the accurate precision of moving liquid measure.The present invention also includes series containers and the chassis that a series of formulas are pre-charged with biochemical operation reagent, both fasten clamping, and be the glued membrane that point of application dismounting covers this flat part with this point, further, when having avoided opening, external pollutant or envelope film surface dirty attaches the reagent in the series containers and obscured the purity of nucleic acid purification, extraction, screening or detection.
Embodiment
For making above-mentioned purpose of the present invention more can show understandable, following system will cooperate appended graphic, to elaborate.
See also Fig. 1 and Fig. 2, liquid-transfering device of the present invention and be used in transfer pipet and series containers in this device, it includes a transfer pipet 100, be an axially extended hollow taper thing, can one-body moldedly also can form by plural elements combination, has first terminal 103 and second end 104, its second end 104 is provided with a fixed part 101, but make this transfer pipet 100 can be clamped and fixed on the mechanical arm 203 with a fixed part 102 by this fixed part 101, it is by a motor 2031, transmission component 2032, power axle 2033, panel 2034 constitutes (seeing also the 2nd figure), but this mechanical arm 203 has several fixed parts 102, but with respect to also being provided with several fixed parts 101 on these fixed part 102 these transfer pipets 100, but interference engagement clamping mutually after this fixed part 101 and fixed part 102 both contrapositions, and this transfer pipet 100 is connected on this mechanical arm 203 with radial direction.Transfer pipet of the present invention can tangential movement mode install or remove, in order to being reduced in the cross pollution that is produced in the clamping process, but this only is a kind of installation aspect of the present invention, the present invention is not limited in radially and installs.Again, but should fixed part 102 be to be used for limiting this transfer pipet 100 to be connected to height and position on this mechanical arm 203.
See also Fig. 3, wherein demonstrate the synoptic diagram when operating according to a preferred embodiment of the present invention.As shown in Figure 3, liquid-transfering device of the present invention and be used in transfer pipet and series containers in this device, it utilizes haulage gear 207 to produce an acting force, the change that traction or compression produce volumes with the closed variable volume air bag 204 of these transfer pipets 100 of being fixed therein, form pressure differential, and then reach the release and the absorption of reagent in the transfer pipet.Produce an acting force A upwards by 207 pairs of these transfer pipets of this haulage gear 100, cause the volume of this closed variable volume air bag 204 to become big, make the reagent that is filled in advance in the 301a of this nest chamber be temporarily stored in this liquid storage cavity 205 by this nozzle 206 simultaneously by absorption, utilize this mechanical arm 203 (seeing also Fig. 2) upwards to drive along major axes orientation, the reagent that is temporarily stored in the storage cavity 205 is moved toward next nest chamber 301 in regular turn, to carry out nucleic acid purification, extraction, screening or detection.
As shown in Figure 4,207 pairs of these transfer pipets 100 of this haulage gear also can produce a downward acting force B, cause the smaller volume of this closed variable volume air bag 204, discharge by this nozzle 206 simultaneously and be temporarily stored in the interior reagent of this storage cavity 205, mix with reagent in being filled in nest chamber 301a in advance in regular turn.As previously mentioned, this haulage gear 207 can reciprocating typely compress, in other words, promptly this transfer pipet 100 is produced upwards an acting force A or a downward acting force B, directly changed the volume of this closed variable volume air bag 204, it not only can be controlled this transfer pipet 100 and draw or discharge reagent in this liquid storage cavity 205, can guarantee the consistance of these closed variable volume air bag 204 recovery rate again.The present invention is not limited to utilize haulage gear 207 to act on this closed variable volume air bag 204 and makes this transfer pipet 100 carry out the absorption and the release of reagent, it can further change and combination according to the demand of particular implementation aspect, but its main points are the change that closed variable volume air bag 204 produces volume, form pressure differential, and then reach the release and the absorption of reagent in the transfer pipet 100.
See also Fig. 5 A, Fig. 5 B, Fig. 6 A, Fig. 6 B, Fig. 7 A and Fig. 7 B, the present invention also includes a series of containers 300, connecting several nest chambers 301,301a and 301b by a flat part 303 is constituted, insert in advance in regular turn in this series containers 300 and carry out biochemical purification, extraction, screening or detect the corresponding required reagent of step, wherein this flat part 303 is provided with a hole 704 in addition, this hole 704 can be in order to ccontaining one independent nest chamber 706, this independent nest chamber 706 has a lid 705, it is the final product collection cups, therefore is arranged on the ora terminalis of this series containers 300; The magnetic bead reaction nest chamber 301a that one special external form is arranged in this series containers 300 in addition, this magnetic bead reaction 301a bottom, nest chamber is a flat, has a side inclined-plane, can cooperate with a magnetic element C to carry out magnetic resolution (seeing also Fig. 2), also be about to the side inclined-plane of this magnetic element near magnetic bead reaction nest chamber, fixedly be adsorbed on this inclined-plane will be incorporated in the indoor magnetic bead (not shown) of nest, and this transfer pipet goed deep into reagent after the indoor absorption magnetic resolution of nest, see through again and be fixed on magnetic bead on the side inclined-plane, mobile transfer pipet is to this top, inclined-plane and discharge the reagent that is temporarily stored in the fluid storage chamber, draw reagent again, by reagent repetitiousness ground is washed away the magnetic bead that is adsorbed on the side inclined-plane, can obtain the higher extract sample of purity.Also have several temperature control nests chamber 301b in this series containers 300, its corresponding temperature control element D (seeing also Fig. 2) is with the optimum temperature range of control particular process.
After this series containers 300 was inserted in advance and is applicable to biochemical purification, extraction, screening or detects required reagent and damping fluid, other was provided with the surface that a glued membrane 305 covers this flat part 303, covered several series containers 300 to seal fully; Series containers 300 also is provided with a point 306, it is arranged near on flat part 303 surfaces of independent nest chamber (final product collection cups) 706, this point 306 has a little difference in height distance with this flat part 303, and passes through the setting of this point 306, can be easily effectively with glued membrane 305 removals.
These series containers 300 two ends have a buckling parts 302, its quantity is not to be used for limiting to the present invention with the position is set, but with regard to making convenience, from being advisable when the two ends that are arranged on this series containers, it can combine with the chassis 700 with at least one groove 703, this chassis 700 can be used to carry this series containers 300, in addition, this groove 703 has Embedded Division 701,702, the two fastens clamping mutually by this Embedded Division and buckling parts 302, make this series containers 300 be fixed on this chassis 700, utilize this point 306 to cover the glued membrane 305 of this flat part 303 for point of application dismounting again, the pollutant that not only can avoid these glued membrane 305 surfaces is infected with reagent and has been destroyed the purity of final extract, and it seals the loss that the film processing procedure more can be avoided volatile liquids in this series containers 300 closely.This glued membrane 305 can high frequency or mode such as hot pressing seal.In preferred embodiment of the present invention, this series containers 300 is to be made by materials such as polycarbonate, polypropylene, tygon, polystyrene, styrol copolymers.
See also shown in Figure 8, in order to reach biochemical purification, extraction, screening or the accurate control that detects, both this transfer pipet 100 provided by the invention move with a mutual moving-state by mechanical arm 203 and chassis 700, promptly provide moving of vertical or level by seizing the transfer pipet 100 that is fixed on this mechanical arm 203 on both sides by the arms, and these chassis 700 transfixions, and by this draw-gear 207, reagent in this transfer pipet 100 is discharged and absorption, or being clamped to transfer pipet 100 on this mechanical arm 203 provides and moves horizontally and this chassis 700 provides vertical moving, provide vertical moving again or by seizing the transfer pipet 100 that is fixed on this mechanical arm 203 on both sides by the arms, and this chassis 700 provides and moves horizontally, again by this draw-gear 207, reagent in this transfer pipet 100 is discharged and absorption, to finish nucleic acid purification, extraction, screening or the processing procedure that detects.
Compared to previous technology, provided by the present inventionly move liquid device and be used in pipette in this device With series containers, comprise the disposable sealed hollow taper pipette of abandoning, exempted and moved liquid Produce easily the problem of cross-infection in the process, the processing procedure that can abandon of pipette closed of the present invention is complete again Entirely overcome the operation sequence of existing product complexity, but still possessed the accurate precision of moving liquid measure. The present invention also Include series containers and chassis that a series of formulas are pre-charged with biochemical operation reagent, both buttons close card and connect, And take this tip section as the point of application dismounting covers the glued membrane of this flat board section, further, avoided opening The time, external pollutant or sealer surface dirty attaches the reagent in the series containers and obscured nuclear The purity of acid purifying, extraction, screening or detection.
Claims (20)
1. liquid-transfering device, it is characterized in that: described liquid-transfering device includes: transfer pipet, series containers, envelope film and action control gear, wherein said transfer pipet has the inside of hollow and is axially extended first terminal and second end, this first end is provided with an opening, and described second end has a closed elastic variable volume, when the stereomutation of this elastic variable volume, form pressure differential, and making described transfer pipet produce suction and release force and described, transfer pipet is provided with at least one fixed part; Described series containers connects a plurality of nests chamber by a flat part and constitutes, and is provided with a buckling parts; Described envelope film is one to cover the glued membrane on the surface of this flat part fully; And, described action control gear, comprise mechanical arm and chassis, this chassis has groove, and has Embedded Division in the described groove, utilize the buckling parts and the mutual snapping of Embedded Division that is arranged in the groove of chassis of described series containers, described series containers is fixed on this chassis.
2. liquid-transfering device as claimed in claim 1, it is characterized in that: the described transfer pipet second terminal closed elastic variable volume that is provided with is a closed variable volume air bag, and this air bag is a flexible snake fu jie structure and is made and the shape of this air bag can be one of them of in-line arrangement or cross-arranging type by elastic material.
3. liquid-transfering device as claimed in claim 2 is characterized in that: described air bag also can be an elastic construction, and it is shaped as sphere.
4. liquid-transfering device as claimed in claim 1 is characterized in that: but described mechanical arm is provided with at least one fixed part, but should seize on both sides by the arms fixing mutually with the fixed part that is arranged on the described transfer pipet by fixed part.
5. liquid-transfering device as claimed in claim 1, it is characterized in that: described action control gear includes haulage gear, it can produce an acting force to described transfer pipet, and the volume of described closed elastic variable volume is changed, and makes this transfer pipet produce suction and release force.
6. liquid-transfering device as claimed in claim 1 is characterized in that: the fixed part of described transfer pipet can be the Shu wherein in groove, annular ditch groove, the hole.
7. liquid-transfering device as claimed in claim 1, it is characterized in that: described flat part is provided with hole in addition, and this hole can ccontaining one independent nest chamber, and this independent nest chamber has a lid, be the final product collection cups, and this final product collection cups is arranged on the ora terminalis of this series containers.
8. liquid-transfering device as claimed in claim 1, it is characterized in that: the indoor magnetic bead reaction nest chamber that is provided with of a plurality of nests of described series containers, its bottom is a flat, and has a side inclined-plane, carries out the magnetic bead that magnetic resolution used in order to convenient fixedly nest is indoor.
9. liquid-transfering device as claimed in claim 1 is characterized in that: a plurality of nests of described series containers are indoor also to have a plurality of temperature control nests chamber, to provide this liquid-transfering device required temperature control.
10. liquid-transfering device as claimed in claim 7 is characterized in that: its flat part surface near this final product collection cups of described series containers is provided with a point.
11. liquid-transfering device as claimed in claim 1, it is characterized in that: the transfer pipet of installing and chassis can be start relation in the described action control gear, this start relation can be described transfer pipet and is level, vertical direction displacement, and described chassis transfixion, also can be the displacement in horizontal direction of described transfer pipet, and displacement in vertical direction of described chassis or the displacement in vertical direction of described transfer pipet, and the displacement in horizontal direction of described chassis.
12. a transfer pipet is applied to it is characterized in that in the liquid-transfering device:
Described transfer pipet has the inside of hollow and is positioned at first terminal and second end at axial two ends, this first end is provided with an opening, and this second end has a closed elastic variable volume, when the stereomutation of described elastic variable volume, form pressure differential, and making described transfer pipet produce suction and release force, described transfer pipet is provided with at least one fixed part.
13. transfer pipet as claimed in claim 12, it is characterized in that: described fixed part can be the Shu wherein in groove, annular ditch groove, the hole, described transfer pipet can be seized on both sides by the arms and be fixed on the miscellaneous part, described fixed part also can be arranged at arbitrary position of this transfer pipet except second end that is arranged at this transfer pipet.
14. transfer pipet as claimed in claim 12, it is characterized in that: it is a closed variable volume air bag that second end of described transfer pipet is provided with closed elastic variable volume, but described air bag is a flexible snake fu jie structure and is made and the shape in-line arrangement of this air bag or one of them of cross-arranging type by elastic material.
15. transfer pipet as claimed in claim 12 is characterized in that: described air bag be an elastic construction its be shaped as sphere.
16. a series containers is applied to it is characterized in that in the liquid-transfering device: described series containers connects several nest chambers by a flat part and constitutes, and described series containers is provided with a buckling parts; This series containers also includes an envelope film, and described envelope film is a glued membrane, and it covers the surface of described flat part fully.
17. series containers as claimed in claim 16 is characterized in that: the buckling parts of described series containers can be fixed back clamping one stationary state mutually with the parts that are provided with an Embedded Division.
18. series containers as claimed in claim 16, it is characterized in that: the flat part of described series containers is provided with this hole of hole in addition can ccontaining one independent nest chamber, this independent nest chamber has a lid, it is the ora terminalis that final product collection cups and described final product collection cups are arranged on this series containers, and other is provided with a point, and it is located near on the flat part surface of described final product collection cups.
19. series containers as claimed in claim 16, it is characterized in that: have magnetic bead reaction nest chamber in a plurality of nests chamber of described series containers, its bottom is a flat, and has a side inclined-plane, carries out the magnetic bead that magnetic resolution used in order to convenient fixedly nest is indoor.
20. series containers as claimed in claim 16 is characterized in that: also have a plurality of temperature control nests chamber in described a plurality of nests chamber, to provide this liquid-transfering device required temperature control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100467502A CN101398437A (en) | 2007-09-30 | 2007-09-30 | Liquid transfering device, liquid transfering tube used in the device and series containers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100467502A CN101398437A (en) | 2007-09-30 | 2007-09-30 | Liquid transfering device, liquid transfering tube used in the device and series containers |
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| Publication Number | Publication Date |
|---|---|
| CN101398437A true CN101398437A (en) | 2009-04-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100467502A Pending CN101398437A (en) | 2007-09-30 | 2007-09-30 | Liquid transfering device, liquid transfering tube used in the device and series containers |
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| CN (1) | CN101398437A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343305A (en) * | 2010-08-02 | 2012-02-08 | 芮宝生医股份有限公司 | Integrated reaction cartridge |
| CN106754339A (en) * | 2016-12-14 | 2017-05-31 | 杭州杰毅麦特医疗器械有限公司 | Detection of nucleic acids pre-treatment automatic processing device |
| CN108371597A (en) * | 2018-03-30 | 2018-08-07 | 郑萍华 | A kind of novel medical device |
| CN108528499A (en) * | 2018-03-30 | 2018-09-14 | 郑萍华 | A kind of Medical Devices |
| CN108751104A (en) * | 2018-03-30 | 2018-11-06 | 郑萍华 | A kind of Medical Devices of stabilization |
| CN109696556A (en) * | 2017-10-24 | 2019-04-30 | 豪夫迈·罗氏有限公司 | Liquid-transfering device and liquid-transfering device positioning system |
| CN110305773A (en) * | 2019-08-22 | 2019-10-08 | 深圳市芯思微生物科技有限公司 | A kind of nucleic acid-extracting apparatus and extracting method |
| CN110743643A (en) * | 2019-11-27 | 2020-02-04 | 庄培明 | Test-tube rack of culture medium preparation machine |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
-
2007
- 2007-09-30 CN CNA2007100467502A patent/CN101398437A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343305B (en) * | 2010-08-02 | 2014-08-27 | 芮宝生医股份有限公司 | Integrated reaction cartridge |
| CN102343305A (en) * | 2010-08-02 | 2012-02-08 | 芮宝生医股份有限公司 | Integrated reaction cartridge |
| CN106754339A (en) * | 2016-12-14 | 2017-05-31 | 杭州杰毅麦特医疗器械有限公司 | Detection of nucleic acids pre-treatment automatic processing device |
| CN109696556A (en) * | 2017-10-24 | 2019-04-30 | 豪夫迈·罗氏有限公司 | Liquid-transfering device and liquid-transfering device positioning system |
| CN109696556B (en) * | 2017-10-24 | 2023-08-22 | 豪夫迈·罗氏有限公司 | Pipetting device and pipetting device positioning system |
| CN108371597A (en) * | 2018-03-30 | 2018-08-07 | 郑萍华 | A kind of novel medical device |
| CN108751104A (en) * | 2018-03-30 | 2018-11-06 | 郑萍华 | A kind of Medical Devices of stabilization |
| CN108528499A (en) * | 2018-03-30 | 2018-09-14 | 郑萍华 | A kind of Medical Devices |
| CN110305773A (en) * | 2019-08-22 | 2019-10-08 | 深圳市芯思微生物科技有限公司 | A kind of nucleic acid-extracting apparatus and extracting method |
| CN110743643A (en) * | 2019-11-27 | 2020-02-04 | 庄培明 | Test-tube rack of culture medium preparation machine |
| CN110743643B (en) * | 2019-11-27 | 2021-11-30 | 南京轩世琪源软件科技有限公司 | Test-tube rack of culture medium preparation machine |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
| CN113820195B (en) * | 2021-11-25 | 2022-03-08 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
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Open date: 20090401 |