CN102343305B - Integrated reaction cartridge - Google Patents
Integrated reaction cartridge Download PDFInfo
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- CN102343305B CN102343305B CN201010243807.XA CN201010243807A CN102343305B CN 102343305 B CN102343305 B CN 102343305B CN 201010243807 A CN201010243807 A CN 201010243807A CN 102343305 B CN102343305 B CN 102343305B
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Abstract
The invention relates to an integrated reaction cartridge comprising a plurality of reaction containers and at least one separation container. The plurality of reaction containers and the separation container are made of a plastic substrate material in an integral form and lined in a first direction. The separation container consists of a first end, a second end opposite to the first end, and a hollow accommodation space located between the first end and the second end. The first end is an open end, while the second end is a closed end. Shrinking from the first end to the second end, the accommodation space has a first side and a second side along the first direction, as well as a third side and a fourth side along a second direction. And the second direction is perpendicular to the first direction. Also near the second end, at least one of the first side and the second side has a less scope than the third side and the fourth side.
Description
Technical field
The present invention is relevant a kind of integral type reaction casket, particularly relevant for the integral type of isolation of target substances, reacts casket.
Background technology
In the middle of the field of purifying biomolecules separation, adopt magnetic separation technique to become current industry trend.So-called magnetic separation technique is the characteristic of utilizing magnetic particle to have can be subject to magnetic fields absorption, target substance with magnetic particle is separated from complicated and high vicidity mixture, can be used as the purposes such as biochemical affine absorption, protein or separate nucleic acid, cell marking and classification, immunochemistry.Magnetic separation technique sharpest edges are to obtain efficiently the target substance that purity is high.When magnetic fields power removes, target substance can be rushed and carries in purification devices.So, the tradition, complicated such as, filtration centrifugal compared to using or chromatography, and it is destroyed and cause the risk of target substance activity decreased often to need to use the separation method of multiple chemical medicament, magnetic separation technique can be reduced in target substance in purge process.
The genetic test of object now of take is example, target substance, mixed liquor must be inserted to the reaction vessel that reacts casket with magnetic particle in the middle of, treat that this three fully reacts to make magnetic particle absorption target substance.Thereafter, by draw frame machine, three is inserted to the separation container of reaction in casket, and self-separation external container imposes an externally-applied magnetic field, target substance and magnetic particle can be concentrated on the wall that is adsorbed on separation container.Then with draw frame machine, insert in the middle of separation container sucking-off without other material of magnetic particle absorption again, and remove externally-applied magnetic field, now in separation container, can remain the target substance through magnetic particle absorption.Yet the position of inserting separation container when draw frame machine is incorrect, can, by target substance and the related sucking-off of magnetic particle, reduce the accuracy of testing result.For avoiding this problem, or can on draw frame machine, improve, but improved, process is complicated time-consuming, the accuracy that therefore how to promote testing result reduces testing cost simultaneously becomes the problem that industry utmost point wish solves.
Summary of the invention
The object of the present invention is to provide a kind of integral type reaction casket, to promote the accuracy of testing result, reduce testing cost simultaneously.
For achieving the above object, integral type reaction casket provided by the invention, include a plurality of reaction vessels and at least one separation container, wherein, these a plurality of reaction vessels and this separation container are to be made so that a plastic basis material is one-body molded, and arrange in line with first direction, this separation container has first end, the second end with respect to this first end, and the accommodation space of the hollow form between this first end and the second end, this first end is an opening, this second end is a blind end, this accommodation space dwindles towards the second end gradually from first end, this accommodation space has first side and Second Edge along first direction, this accommodation space has the 3rd limit and the 4th limit along second direction, wherein this second direction is perpendicular to this first direction, and contiguous the second end place, in this first side and Second Edge, wherein convergent gradient is less than the 3rd limit and the 4th limit convergent gradient at least on one side.
Described integral type reaction casket, wherein, contiguous the second end place of the accommodation space of this separation container, this first side and Second Edge convergent gradient are all less than the 3rd limit and the 4th limit convergent gradient.
Described integral type reaction casket, wherein, the opening of this first end, is greater than the width along second direction along the width of first direction.
Integral type reaction casket provided by the invention, also include a plurality of reaction vessels and one first separation container and one second separation container, wherein, these a plurality of reaction vessels, the first separation container and the second separation container are to be made so that a plastic basis material is one-body molded, and with the first direction arrangement that is in line, the first separation container and the second separation container are adjacent to each other, the first separation container and the second separation container all have first end, the second end with respect to this first end, and the accommodation space of the hollow form between each first end and each the second end, and those accommodation spaces dwindle towards each second end gradually from each first end respectively, and at contiguous the second end place, one side convergent gradient that these two accommodation spaces are adjacent is all less than each accommodation space along one side convergent gradient of second direction, wherein this second direction is perpendicular to this first direction.
Described integral type reaction casket, wherein, the accommodation space of each separation container is in the opening part of each first end, along the width of this first direction, is greater than the width along this second direction.
Integral type provided by the invention reaction casket, by the Configuration Design of separation container, the target substance that can avoid draw frame machine to inhale magnetic particle by mistake and adsorb, can promote the purity of end product.
Accompanying drawing explanation
Figure 1A is the schematic diagram of the first preferred embodiment integral type reaction casket of the present invention.
Figure 1B is the first preferred embodiment integral type reaction casket separation container part schematic diagram of the present invention.
Fig. 1 C is that the present invention's the first preferred embodiment integral type reaction casket separation container is along the generalized section of first direction.
Fig. 1 D is that the first preferred embodiment integral type reaction casket separation container of the present invention is along the generalized section of second direction.
Fig. 1 E is that the first preferred embodiment integral type reaction casket separation container of the present invention is along the online generalized section of CC.
Fig. 1 F is that the first preferred embodiment integral type reaction casket separation container of the present invention is along the online generalized section of DD.
Fig. 1 G is the first preferred embodiment integral type reaction casket separation container operation chart of the present invention.
Fig. 2 A is the schematic diagram of the second preferred embodiment integral type reaction casket of the present invention.
Fig. 2 B is the part schematic diagram of second preferred embodiment integral type reaction casket the first separation container of the present invention and the second separation container.
Primary clustering symbol description in accompanying drawing:
Integral type reaction casket 1,2; Reaction vessel 11,21; Separation container 12; The first separation container 22; The second separation container 23; First end 121,221,231; The second end 122,222,232; Accommodation space 123,223,233; First side 1231,2231; Second Edge 1232,2232; The 3rd limit 1233,2233; The 4th limit 1234,2234; The 5th limit 2331; Hexagon 2332; The 7th limit 2333; The 8th limit 2334; Externally-applied magnetic field 3; Draw frame machine 4; Magnetic particle M; First direction X; Second direction Y; Third direction Z; Convergent gradient β 1, β 2, θ 1, θ 2; Width W x, Wy, Wx ', Wy '.
The specific embodiment
Integral type reaction casket provided by the invention, includes a plurality of reaction vessels and at least one separation container.A plurality of reaction vessels and separation container are to be made so that plastic basis material is one-body molded, and are arranged in a straight line with first direction.Separation container has first end, with respect to the second end of first end and the accommodation space of the hollow form between first end and the second end.First end is opening, and the second end is a blind end.Accommodation space dwindles towards the second end gradually from first end.Accommodation space has first side and Second Edge along first direction, and accommodation space has the 3rd limit and the 4th limit along second direction.Second direction is perpendicular to first direction, and contiguous the second end place, and in first side and Second Edge, wherein convergent gradient is less than the 3rd limit and the 4th limit convergent gradient at least on one side.
In addition, the present invention also provides another kind of integral type reaction casket, includes a plurality of reaction vessels and two separation containers.A plurality of reaction vessels and separation container are to be made so that plastic basis material is one-body molded, and are arranged in a straight line with first direction.Two separation containers are adjacent to each other, and each separation container has first end, with respect to the second end of first end and the accommodation space of the hollow form between first end and the second end.First end is opening, and the second end is blind end.Accommodation space dwindles towards the second end gradually from first end.In contiguous the second end place, the convergent gradient on one side that two separation containers are adjacent is all less than the convergent gradient along second direction, and wherein second direction is perpendicular to first direction.
Due to integral type provided by the invention reaction casket, the separated separation principle of the purifying biomolecules that wherein utilized, has been that various equivalent modifications can understand, therefore with explanation hereinafter, no longer do complete description.Meanwhile, with the accompanying drawing hereinafter being contrasted, be to express the structural representation relevant with feature of the present invention, also do not need according to the complete drafting of actual size.
Please refer to Figure 1A, for the invention provides the schematic diagram of the first preferred embodiment integral type reaction casket.Integral type reaction casket 1 includes a plurality of reaction vessels 11 and separation container 12, and its material is plastic basis material, and is formed in one and is made, and reaction vessel 11 and separation container 12 are along the first direction X arrangement that is in line.
Please refer to Figure 1B, is the schematic diagram of separation container part in the present invention's the first preferred embodiment integral type reaction casket.Separation container 12 has first end 121 and the second end 122, and relative to each other, and first end 121 is opening for first end 121 and the second end 122, and the second end 122 is blind end.Again, between first end 121 and the second end 122, separation container 12 has the accommodation space 123 of hollow form.
Refer again to Fig. 1 C, in Figure 1B along being parallel to the online profile of AA of first direction X.Accommodation space 123 has first side 1231 and Second Edge 1232 on first direction X, first side 1231 is towards accommodation space 123 central shaft 1235 convergents with Second Edge 1232, the convergent gradient of first side 1231 is β 1, and the convergent gradient of Second Edge 1232 is β 2.Please also refer to Fig. 1 D, in Figure 1B along being parallel to the online profile of BB of second direction Y.Accommodation space 123 second direction Y are upper, have the 3rd limit 1233 and the 4th limit 1234, and the 3rd limit 1233 and the 4th limit 1234 be also towards accommodation space 123 central shaft 1235 convergents, and the 3rd limit 1233 and the 4th limit 1234 have respectively convergent gradient θ 1 and θ 2; And the convergent gradient θ 1 on the 3rd limit 1233 or the convergent gradient θ 2 on the 4th limit 1234 are greater than the convergent gradient β 1 of first side 1231 and the convergent gradient β 2 of Second Edge 1232, that is: θ 1> β 1 and θ 1> β 2, or θ 2> β 1 and θ 2> β 2.Though show in Fig. 1 C that the convergent gradient θ 1 on the 3rd limit 1233 is greater than the convergent gradient β 1 of first side 1231 and the convergent gradient β 2 of Second Edge 1232, but those skilled in the art all can understand the design that the convergent gradient θ 2 on the 4th limit 1234 is greater than convergent gradient β 1 with the convergent gradient β 2 of Second Edge 1232 of first side 1231, also belong to the equivalent replacement under same inventive concept.
According to above-mentioned design, the accommodation space 123 of separation container 12 can be by first end 121 places, to the second end 122, dwindle gradually, and the accommodation space 123 of separation container 12 is vertical with first direction X and second direction Y at third direction Z(third direction Z at first side 1231) upper from first end 121 toward the second end 122 places, can progressively reduce into wedge angle configuration by circular arc configuration.Please refer to Fig. 1 E and Fig. 1 F, be respectively the generalized section that separation container 12 is online along CC and DD is online shown in Fig. 1 C.First, as shown in Fig. 1 E, accommodation space 123 is near first end 121 places, its first side 1231 be configured as circular arc configuration.In addition, please also refer to Fig. 1 C, Fig. 1 D and Fig. 1 F, Fig. 1 F is that separation container 12 is near the profile of the second end 122.As previously mentioned, because first side 1231, Second Edge 1232, the 3rd limit 1233 and the 4th limit 1234 of accommodation space 123 is all towards accommodation space 123 central shaft 1235 convergents, and the convergent gradient θ 1 on the 3rd limit 1233 is greater than the convergent gradient β 1 of first side 1231 and the convergent gradient β 2 of Second Edge 1232, therefore separation container 12 is at close the second end 122 places, the configuration of first side 1231 can form wedge angle configuration.
Please refer to Fig. 1 G, the schematic diagram when separation container is partly used in the present invention's the first preferred embodiment integral type reaction casket.In use, externally-applied magnetic field 3 is positioned over to first side 1231 near the second end 122 places, with the magnetic particle M of target substance, can be subject to externally-applied magnetic field 3 and attracts and be gathered in herein.Again because accommodation space 123 is apered to wedge angle configuration at first side 1231 near the second end 122 places, so magnetic particle M can be gathered into a strip along the first side 1231 near the second end 122.Therefore, when draw frame machine 4 is inserted after accommodation space 123, during by liquid sucking-off wherein, the suction producing while being difficult for being drawn with the magnetic particle M of target substance and vortex disturbance and make to float on once again in liquid with the magnetic particle M of target substance, and then avoid draw frame machine 4 mistakes to inhale the magnetic particle M with target substance.In addition, in such cases, draw frame machine 4 can lengthen the time of drawing liquid in separation container 12, or increase the suction of drawing, more complete so that the liquid assimilating in separation container 12 is obtained, and then to avoid the purifying productive rate that causes because of the inner residual liquid of separation container 12 to reduce be very purifying failure.
Again, refer again to Figure 1B, separation container 12, at the opening of first end 121, has width W x along first direction X, and has width W y along second direction Y, and width W x be take and is greater than width W y as good.
In addition, the present invention also provides the second preferred embodiment, for another kind of integral type reaction casket, wherein the number of reaction vessel, use the allocation position of material, reaction vessel and separation container, all with the first preferred embodiment in roughly the same, therefore do not repeat them here, below for this preferred embodiment and aforementioned the first preferred embodiment difference locate further illustrate.
Please refer to Fig. 2 A, is a kind of integral type reaction casket 2.Integral type reaction casket 2 includes a plurality of reaction vessels 21, the first separation container 22 and the second separation container 23.Reaction vessel 21, the first separation container 22 and the second separation container 23 are to be made so that plastic basis material is one-body molded, and arranged in a straight line along first direction X.
Please refer to Fig. 2 B, is separation container part schematic diagram in the present invention's the second preferred embodiment integral type reaction casket.The first separation container 22 and the second separation container 23 are adjacent to each other.The first separation container 22 is identical with the separation container 12 described in the first preferred embodiment, has first end 221 and the second end 222, and relative to each other, and first end 221 is opening for first end 221 and the second end 222, and the second end 222 is blind end.Again, between first end 221 and the second end 222, the first separation container 22 has the accommodation space 223 of hollow form.In addition, the accommodation space 223 of the first separation container 22 has first side 2231 and Second Edge 2232 on first direction X, and on the second direction Y perpendicular to first direction X, there is the 3rd limit 2233 and the 4th limit 2234, above-mentioned first side 2231, Second Edge 2232, the 3rd limit 2233 are identical with the 4th limit 1234 with first side 1231, Second Edge 1232, the 3rd limit 1233 in the 4th limit 2234 its relativenesses and configuration characteristic and the first preferred embodiment, and at this, it is no longer repeated.
The second separation container 23 also have first end 231 and with the second end 222 with respect to first end 231.First end 231 is opening, and the second end 232 is blind end.Again, between first end 231 and the second end 232, the second separation container 23 has the accommodation space 233 of hollow form.
The accommodation space 233 of the second separation container 23 has the 5th limit 2331 and hexagon 2332 on first direction X, and on the second direction Y perpendicular to first direction X, has the 7th limit 2333 and the 8th limit 2334 with respect to the 7th limit 2333.And wherein the 5th limit 2331 is adjacent with the first side 2231 of the first separation container 22, and towards accommodation space 223 center convergents.
The present embodiment and the first preferred embodiment difference part be, except the convergent gradient of the first side 2231 of above-mentioned second end 222 place's the first separation containers 22 at contiguous the first separation container 22 is less than the first separation container 22 along arbitrary limit (the 3rd limit 2233 or the 4th limit 2234) convergent gradient of second direction Y; The 5th limit 2331 that the second separation container 23 is adjacent with the first separation container 22 at its second end 223 places, its convergent gradient is also less than the second separation container 23 along arbitrary limit (the 7th limit 2333 or the 8th limit 2334) convergent gradient of second direction Y.
In use, externally-applied magnetic field 3 is positioned over to the first side 2231 of the first separation container 22 near the second end 222 places, with the magnetic particle M of target substance, can be subject to externally-applied magnetic field 3 and attracts and be gathered in herein.Accommodation space 223 due to the first separation container 22 is apered to wedge angle configuration at first side 2231 near the second end 222 place systems again, so magnetic particle M can be gathered into a strip along the first side 2231 near the second end 222.Therefore, when draw frame machine 4 is inserted after accommodation space 223, during by liquid sucking-off wherein, the suction producing while being difficult for being drawn with the magnetic particle M of target substance and vortex disturbance and make to float on once again in liquid with the magnetic particle M of target substance, and then avoid draw frame machine 4 mistakes to inhale the magnetic particle M with target substance.Same, externally-applied magnetic field 3 is positioned over the 5th limit 2331 of the second separation container 23 near the second end 232 places, and magnetic particle M can be subject to externally-applied magnetic field 3 and attracts and be gathered in herein.Accommodation space 223 due to the first separation container 22 is apered to wedge angle configuration at first side 2231 near the second end 222 places again, so magnetic particle M can be gathered into a strip along the first side 2231 near the second end 222.Therefore, when draw frame machine 4 is inserted after accommodation space 223, during by liquid sucking-off wherein, the suction producing while being difficult for being drawn with the magnetic particle M of target substance and vortex disturbance and make to float on once again in liquid with the magnetic particle M of target substance, and then avoid draw frame machine 4 mistakes to inhale the magnetic particle M with target substance
Therefore, under the above-mentioned state that arranges, draw frame machine 4 can lengthen the time of drawing liquid in the first separation container 22 or the second separation container 23, or increase the suction of drawing, more complete so that the liquid assimilating in the first separation container 22 or the second separation container 23 is obtained, so the purifying productive rate of avoiding causing because of the first separation container 22 or the inner residual liquid of the second separation container 23 to reduce be very purifying failure.
Refer again to Fig. 2 B, the first separation container 22, at the opening of first end 221, has width W x along first direction X, and has width W y along second direction Y, and width W x be take and is greater than width W y as good.Meanwhile, the second separation container 23, at the opening of first end 231, has width W x ' along first direction X, and has width W y ' along second direction Y, and width W x ' also be take and is greater than width W y ' as good.
The foregoing is only preferred embodiment of the present invention, not in order to limit interest field of the present invention; Simultaneously above description, should understand and implement for those skilled in the art, so other does not depart from the equivalence completing under disclosed spirit and change or modification, all should be included in interest field.
Claims (2)
1. an integral type is reacted casket, include a plurality of reaction vessels and at least one separation container, these a plurality of reaction vessels and this separation container are to be made so that a plastic basis material is one-body molded, and arrange in line with first direction, this separation container has first end, the second end with respect to this first end, and the accommodation space of the hollow form between this first end and the second end, this first end is an opening, this second end is a blind end, this accommodation space dwindles towards the second end gradually from first end, this opening is greater than the width along second direction along the width of first direction, this accommodation space has first side and Second Edge along first direction, and this accommodation space has the 3rd limit and the 4th limit along second direction, and wherein this second direction is perpendicular to this first direction, it is characterized in that:
Contiguous the second end place, the convergent gradient of this first side and this Second Edge is all less than the convergent gradient on the 3rd limit and the 4th limit; Make this accommodation space towards the second end, progressively by a circular arc configuration, be apered to a wedge angle configuration from first end.
2. an integral type is reacted casket, include a plurality of reaction vessels and one first separation container and one second separation container, these a plurality of reaction vessels, this first separation container and this second separation container are to be made so that a plastic basis material is one-body molded, and with the first direction arrangement that is in line, this first separation container and this second separation container are adjacent to each other, it is an opening that this first separation container and this two separation container have first end respectively, the second end with respect to this first end is a blind end, and the accommodation space of the hollow form between each first end and each the second end, and those accommodation spaces dwindle towards each second end gradually from each first end respectively, the accommodation space of this first separation container one side is in a first direction adjacent on one side of first direction with the accommodation space of this second separation container, this opening is greater than the width along second direction along the width of first direction, it is characterized in that:
Contiguous each second end place, these two accommodation spaces are adjacent and be all less than each accommodation space along the convergent gradient on arbitrary limit of second direction along the convergent gradient on one side of first direction, and wherein this second direction is perpendicular to this first direction; This accommodation space is progressively apered to a wedge angle configuration by a circular arc configuration from first end towards the second end.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010243807.XA CN102343305B (en) | 2010-08-02 | 2010-08-02 | Integrated reaction cartridge |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010243807.XA CN102343305B (en) | 2010-08-02 | 2010-08-02 | Integrated reaction cartridge |
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| Publication Number | Publication Date |
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| CN102343305A CN102343305A (en) | 2012-02-08 |
| CN102343305B true CN102343305B (en) | 2014-08-27 |
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| CN201010243807.XA Active CN102343305B (en) | 2010-08-02 | 2010-08-02 | Integrated reaction cartridge |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0691541A2 (en) * | 1994-07-07 | 1996-01-10 | Roche Diagnostics GmbH | Method and device for separating magnetic particles |
| CN1506460A (en) * | 2002-12-09 | 2004-06-23 | �廪��ѧ | Method and kit for separating cell particle from sample |
| CN101368951A (en) * | 2007-08-13 | 2009-02-18 | 财团法人工业技术研究院 | Magnetic conversion separation device |
| CN101398437A (en) * | 2007-09-30 | 2009-04-01 | 梁栋 | Liquid transfering device, liquid transfering tube used in the device and series containers |
-
2010
- 2010-08-02 CN CN201010243807.XA patent/CN102343305B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0691541A2 (en) * | 1994-07-07 | 1996-01-10 | Roche Diagnostics GmbH | Method and device for separating magnetic particles |
| CN1506460A (en) * | 2002-12-09 | 2004-06-23 | �廪��ѧ | Method and kit for separating cell particle from sample |
| CN101368951A (en) * | 2007-08-13 | 2009-02-18 | 财团法人工业技术研究院 | Magnetic conversion separation device |
| CN101398437A (en) * | 2007-09-30 | 2009-04-01 | 梁栋 | Liquid transfering device, liquid transfering tube used in the device and series containers |
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| CN102343305A (en) | 2012-02-08 |
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Address after: 3rd floor, 132 Lane 235, Baoqiao Road, Xindian District, Xinbei City, Taiwan, China Patentee after: Lafayette biomedical Co.,Ltd. Address before: Zhonghe County, Taipei, Taiwan, China Patentee before: RBC Bioscience Corp. |
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