CN106074913A - One treats lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method - Google Patents

One treats lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method Download PDF

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CN106074913A
CN106074913A CN201610701456.XA CN201610701456A CN106074913A CN 106074913 A CN106074913 A CN 106074913A CN 201610701456 A CN201610701456 A CN 201610701456A CN 106074913 A CN106074913 A CN 106074913A
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chinese medicine
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王春兰
孙玉杰
闫倩
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Abstract

The invention discloses one and treat lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method, belong to pharmaceutical technology field；The raw material of Chinese medicine and western medicine compound preparation effective ingredient of the present invention consists of: chlorambucil, dexamethasone, Acetylmidecamycin, prednisone, methotrexate, Membrana Follicularis ovi, tibetan woodbetony flower, Pu, Radix Primulae sieboldii, Adiantum capillus-junosis Rupr., Cortex ulmi pumilae, pod, Exocarpium Citri Grandis, Folium et Caulis Indigoferae Tinctoriae, Herba Begoniae Crassirostris, Herba Erigerontis Annui, Fructus Hippophae and Herba Selaginellae Doederleinii；Chinese medicine and western medicine compound preparation of the present invention has effect of sedation-analgesia, anti-cancer and detumescence, hard masses softening and resolving, treatment lymphoma had significant curative effect, and taking convenience, quick result, good absorbing effect, no dependence, without any side effects, according to clinical verification, lymphoma is had fabulous therapeutic effect, it is possible to effectively improve body immunity.

Description

One treats lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method
Art
The present invention relates to pharmaceutical technology field, particularly relate to one and treat lymphadenomatous Chinese medicine and western medicine compound preparation and preparation side Method.
Background technology
Lymphoma is initiated by the malignant tumor of lymphohematological, mainly shows as Silent Neuritis lymphadenectasis, liver spleen Enlargement, each histoorgan of whole body all can get involved, the heat that occurs together, night sweat, become thin, the General Symptoms such as pruritus.It is divided into non-according to oncocyte Hodgkin lymphoma and Hodgkin lymphoma two class.It is divided into non-Hodgkin lymphoma (NHL) and Huo Qijin lymph according to oncocyte Tumor (HL) two class.Pathological characteristics is that tumor tissue is contained within lymphocyte, eosinophilic granulocyte, plasma cell at Hodgkin lymphoma With specific in-this (Reed-Steinberg) cell, HL be divided into nodositas rich in lymphocytic type according to histological type and Classic, the latter includes lymphocytic predominance, nodular sclerosis, mixed cell type and lymphocytic depletion.NHL sickness rate Far above HL, it is the summation with very strong one group of heterogeneous independent disease, the lymph that on pathology, mainly differentiation degree is different Cell, histiocyte or skein cell, according to the natural history of NHL, can be classified as three big Clinical types, i.e. Highly invasive, Aggressive and indolent lymphoma.
Malignant lymphoma is to have a quite heterogeneous big class tumor, although be apt to occur in lymph node, but due to lymph The characteristic distributions of system so that lymphoma belongs to systemic disease, almost can invade any tissue of whole body and organ.Cause This, the clinical manifestation of malignant lymphoma had both had certain common feature, simultaneously according to different histological type, invaded position and Scope also exists again the biggest difference.Topical manifestations: include shallow table and deep lymph node enlargement, mostly be Silent Neuritis, smooth surface, Activity, the matter laid one's hand on is tough, full, uniform, early ambulant, isolates or is dispersed in cervical region, oxter, groin etc., and late period is the most mutual Merge, with skin adhesion, inertia, or formation ulcer；Pharyngeal lymphaticring pathological changes oropharynx, the root of the tongue, tonsil and the mucosa of nasopharynx part With there is under mucosa abundant lymphoid tissue, form pharyngeal lymphaticring, also known as Webster ring, be the predilection site of malignant lymphoma；Nose The lymphoma overwhelming majority of the primary nasal cavity of lesion cavity is NHL, and main histological type includes nasal cavity NK/T cell lymphoma and more Unrestrained large B cell lymphoid tumor；Diagnosis of Chest Damage in Patients mediastinal lymph nodes is the predilection site of malignant lymphoma, and that is more common in HL and NHL is former Send out Diffuse Large B-Cell Lymphoma and the Precursor T-cell type lymphoma of mediastinum.Circle or similar round or leaflet is had on C-XF Shape shade, lesion growth can oppress bronchus cause pulmonary atelectasis, center of tumor necrosis sometimes forms cavity.Some pulmonary lesions show For the chromic fibrous change of diffusivity, now clinical symptoms is obvious, often have cough, expectoration, breathe hard, dyspnea, secondary infection can have Heating.
The Therapeutic Method that lymphoma is conventional at present has radiotherapy, chemotherapy, operative treatment etc., radiotherapy, chemistry Drug therapy side effect is big, easily kills human body and is permitted normal healthy cell, causes the new chemotherapy of patient and radiation disease, makes Patient's heart, liver,spleen,kidney and digestive system, by infringement in various degree, cause body's immunity to decline, and operative treatment is solid So can excise cancerous protuberance, but cancer embolus existence etc. in the most residual cancer or regional lymph node metastasis or blood vessel, it is easy to recur and shift, and Surgery cost is higher.
Summary of the invention
The invention provides one and treat lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method；Chinese medicine and western medicine compound recipe of the present invention Preparation has effect of sedation-analgesia, anti-cancer and detumescence, hard masses softening and resolving, and treatment lymphoma is had significant curative effect, and the side of taking Just, quick result, good absorbing effect, no dependence, without any side effects, according to clinical verification, lymphoma is had fabulous controlling Therapeutic effect, it is possible to effectively improve body immunity.
For achieving the above object, technical scheme is implemented as follows:
One treats lymphadenomatous Chinese medicine and western medicine compound preparation, makes the raw material group of described Chinese medicine and western medicine compound preparation effective ingredient Become and parts by weight be:
Chlorambucil 0.1～0.2 part, dexamethasone 0.1～0.3 part, Acetylmidecamycin 0.3～0.9 part, prednisone 0.1～0.4 part, methotrexate 0.02～0.1 part, Membrana Follicularis ovi 11～27 parts, tibetan woodbetony flower 10～26 parts, Pu 10～26 Part, Radix Primulae sieboldii 9～25 parts, Adiantum capillus-junosis Rupr. 8～24 parts, Cortex ulmi pumilae 8～24 parts, pod 7～23 parts, Exocarpium Citri Grandis 7～23 parts, wood Blue 7～23 parts, Herba Begoniae Crassirostris 6～22 parts, Herba Erigerontis Annui 6～22 parts, Fructus Hippophae 5～21 parts, Herba Selaginellae Doederleinii 4～20 parts.
Make described Chinese medicine and western medicine compound preparation effective ingredient raw material composition and parts by weight be:
Chlorambucil 0.12～0.18 part, dexamethasone 0.12～0.28 part, Acetylmidecamycin 0.4～0.8 part, sprinkle Buddhist nun pine 0.12～0.38 part, methotrexate 0.03～0.09 part, Membrana Follicularis ovi 15～23 parts, tibetan woodbetony flower 14～22 parts, Pu 14～22 parts, Radix Primulae sieboldii 13～21 parts, Adiantum capillus-junosis Rupr. 12～20 parts, Cortex ulmi pumilae 12～20 parts, pod 11～19 parts, Exocarpium Citri Grandis 11～19 parts, Folium et Caulis Indigoferae Tinctoriae 11～19 parts, Herba Begoniae Crassirostris 10～18 parts, Herba Erigerontis Annui 10～18 parts, Fructus Hippophae 9～17 parts, Herba Selaginellae Doederleinii 8～16 Part.
Make described Chinese medicine and western medicine compound preparation effective ingredient raw material composition and parts by weight be:
Chlorambucil 0.15 part, dexamethasone 0.2 part, Acetylmidecamycin 0.6 part, prednisone 0.25 part, first ammonia butterfly Purine 0.06 part, Membrana Follicularis ovi 19 parts, tibetan woodbetony flower 18 parts, Pu 18 parts, Radix Primulae sieboldii 17 parts, Adiantum capillus-junosis Rupr. 16 parts, Cortex ulmi pumilae 16 parts, pod 15 parts, Exocarpium Citri Grandis 15 parts, Folium et Caulis Indigoferae Tinctoriae 15 parts, Herba Begoniae Crassirostris 14 parts, Herba Erigerontis Annui 14 parts, Fructus Hippophae 13 parts, Herba Selaginellae Doederleinii 12 Part.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, the extraction process including following western medicine composition walks Rapid:
(1) Western medicine chlorambucil, dexamethasone and methotrexate are mixed in proportion put into medicinal cupping, stir with blender Mix uniformly, put into after 70 DEG C of baking oven is dried and cool down, grind to form fine powder, standby；
(2) Western medicine Acetylmidecamycin and prednisone are put into container, add the ethanol of 1～2 times amount, dilution, be placed in With 5～8 DEG C of temperature oven drying at low temperatures in microwave dryer, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put into pulverizer is ground into mixed powder, standby.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, the extraction process including following Chinese medicine ingredients walks Rapid:
(1) by Chinese medicine Membrana Follicularis ovi, tibetan woodbetony flower, Pu, Radix Primulae sieboldii, Adiantum capillus-junosis Rupr., pod, Exocarpium Citri Grandis, Folium et Caulis Indigoferae Tinctoriae, red Herba Lobeliae Chinensis, Herba Erigerontis Annui, Fructus Hippophae and Herba Selaginellae Doederleinii are mixed in proportion puts into container, adds the distilled water of 5～8 times amount, heated and boiled 2 ～3 hours, to extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby With；
(2) Chinese medicine Cortex ulmi pumilae is put into container, carry out pulverization process, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put in super micron mill, be ground into 0.1～10 μm volumes The mixed powder that the micron particles of mean diameter and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, standby With；
(4) mixed powder that above-mentioned steps (3) is obtained adds relative to the quality 3 of described mixed powder～5 times Determining alcohol is the ethanol of 60%～70%, stirring and dissolving obtain ethanol solution, by ethanol solution under conditions of 5 DEG C～10 DEG C quiet Put 24～36 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and Put at this in super micron mill and pulverize 30～50 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and grain Footpath is less than the mixed powder of the nano-scale particle composition of 0.1 μm volume average particle size, standby.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, described mixes Western medicine mixed powder and Chinese medicine Powder mixes, and after stirring, loads capsule shells, makes capsule, obtain described treatment lymphadenomatous Chinese medicine and western medicine compound recipe Preparation.
The property of medicine of Chinese medicine and western medicine used by the present invention is as follows:
Chlorambucil: to cut special syndrome (genital ulcer, aphtha and uveitis syndrome), lupus erythematosus, Witt theorem disease has good therapeutic effect.For treating the concurrent vasculitis of rheumatoid arthritis and with cold agglutinin Autoimmune hemolytic anemia has good result.
Dexamethasone: its acetate conventional, for white or off-white color crystalline powder, odorless, mildly bitter flavor.The easiest Molten, dissolve in methanol or dehydrated alcohol, the most molten in ethanol or chloroform, soluble,very slightly in ether, insoluble in water.Mainly For anaphylaxis and auto-immune inflammatory disease.Such as anaphylaxis diseases such as connective tissue disease, serious bronchial asthma, dermatitis Disease, ulcerative colitis, acute leukemia, malignant lymphoma etc..
Acetylmidecamycin: for white crystalline powder, odorless, bitter in the mouth, atomic it is dissolved in water, is soluble in ethanol, acetone, chlorine In Fang, insoluble in petroleum ether.Can as the succedaneum of erythromycin, be applied to the pars oralis pharyngis caused by sensitive organism, respiratory tract, skin and The part such as soft tissue, biliary tract infects.
Prednisone: its acetate conventional, for white or almost white crystalline powder, odorless, bitter in the mouth.In chloroform easily Molten, the most molten, slightly soluble in ethanol or ethyl acetate, insoluble in water.For connective tissue disease, systemic red yabbi The anaphylactic diseases such as skin ulcer, serious bronchial asthma, dermatomyositis, vasculitis, the disease such as acute leukemia, malignant lymphoma.
Methotrexate: this product is orange-yellow crystalline powder, this product is the most insoluble in water, ethanol, chloroform or ether, In dilute alkaline soln readily soluble, in dilute hydrochloric acid dissolve.It is primarily adapted for use in acute leukemia, breast carcinoma, chorionic epithelioma and pernicious Hydatidiform mole, tumor of head and neck, bone tumor, leukemia meninges spinal cord infiltration, pulmonary carcinoma, genital system tumor, hepatocarcinoma, intractable are common The autoimmune diseases such as psoriasis, systemic lupus erythematosus (sle), dermatomyositis.
Membrana Follicularis ovi: sweet in the mouth, light, property is put down；Return spleen, stomach, lung meridian.Nourishing YIN and clearing away lung-heat, sore, removing nebula, synthetism.Asthma is coughed outside main, Pharyngalgia aphonia, lymphoid tuberculosis, ulcer being unable to heal, the raw cataracta of mesh, the vertigo, trauma fracture." Zhejiang Chinese medicine handbook " carries: " lung heat clearing Fire, dryness-transformation expectorant.Control pharyngalgia aphonia.”
Tibetan woodbetony flower: sweet in the mouth, puckery, warm in nature.Diuresis is relievingd asthma, tonifying YIN, pain relieving.Harness the river swollen, oliguria, asthma, malnutrition, The acupuncture sample pain that osteomyelitis causes.
Pu: sweet in the mouth, cool in nature, nontoxic.Clearing away heat and cooling blood, inducing diuresis to remove edema.Control anemia of pregnant woman's consumptive fever, vaginal bleeding due to excessive movement of fetus, quench one's thirst, aphtha, Hematodiarrhoea, gonorrhea, leucorrhea, edema, scrofula." occupying diet spectrum with breath " carries: " heat clearing away, nourishes blood, eliminating carbuncle, throat, and logical two just.”
Radix Primulae sieboldii: sweet in the mouth, property is put down.Preventing phlegm from forming and stopping coughing.Main cough with asthma abundant expectoration." Jilin Chinese herbal medicine " carries: " relieving cough and resolving phlegm.Control phlegm dyspnea Cough.”
Adiantum capillus-junosis Rupr.: taste is cool, the micro-hardship of property；GUIXIN, bladder warp.Heat-clearing and toxic substances removing, diuresis, cough-relieving.Main dysuria, blood Drench, dysentery, cough, scrofula, acute mastitis, venom, burn and scald." Chinese Higher plant illustrated handbook " carries: " control dysentery, lymphonodi cervicales Core, venom.”
Cortex ulmi pumilae: sweet in the mouth, cold nature；Return lung, spleen, bladder warp.Relieving stranguria by diuresis, eliminates the phlegm, subduing swelling and detoxicating.Main dysuria, Stranguria with turbid discharge, leukorrhagia, cough with asthma abundant expectoration, insomnia, interior external haemorrhage, retention of dead fetus of having difficult labour, carbuncle scrofula, tinea alba, scabies." detailed outline " carries: " profit key, Eliminating dampness by diuresis heat, promoting circulation of body fluid, subduing inflammation.”
Pod: sour in the mouth, cold nature.Dispelling wind detoxifies, and heat-clearing and toxic substances removing is invigorated blood circulation.Main anemopyretic cold, furuncle heating, puerperal cold, Injury and bone fracture.
Exocarpium Citri Grandis: bitter in the mouth, pungent, warm in nature；Return spleen, lung meridian.Drying dampness to eliminate phlegm, regulates the flow of vital energy, and helps digestion.Main air is trembled with fear cough with asthma abundant expectoration, vomiting Singultus, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention." detailed outline is picked up any lost article from the road " carries: " controlling phlegm syndrome, disappear greasy, paddy food stagnation, relieving alcoholic intoxication, alleviating distention in middle-JIAO, solves Eriocheir sinensis poison.”
Folium et Caulis Indigoferae Tinctoriae: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Main encephalitis B, parotitis, acute pharyngolaryngitis, lymph node Inflammation, conjunctival congestion, aphtha, carbuncle furuncle, erysipelas, scabies, worm venom, spit blood.
Herba Begoniae Crassirostris: sour in the mouth, puckery, cool in nature.Removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.Main acute pharyngolaryngitis, gingival swelling and pain, furuncle swells Poison, calentura has blood in stool, scrofula, scabies, venom, burn and scald.Guangzhou air force " conventional Chinese herbal medicine handbook " carries: " control scabies, unknown Toxic swelling, lymphoid tuberculosis, esophageal carcinoma.”
Herba Erigerontis Annui: sweet in the mouth, hardship, cool in nature.Return stomach, large intestine channel.Help digestion antidiarrheal, heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria.Main dyspepsia, stomach Enteritis, gingivitis, malaria, venom." Zhejiang conventional medical herbs among the people " carries: " help digestion, antidiarrheal, removing toxic substances, hemostasis.”
Fructus Hippophae: sour in the mouth, puckery, warm in nature.Relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis.Main cough with copious phlegm, pulmonary abscess, digestion is not Good, abdominal pain due to retention of food, stomachache, enteritis, amenorrhea, traumatic injury congestive edema.
Herba Selaginellae Doederleinii: sweet in the mouth, micro-hardship, puckery, cool in nature, light, warm.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Main laryngopharynx swelling and pain, conjunctival congestion and swelling pain, Cough due to lung-heat, mastitis, jaundice due to damp-heat, rheumatic arthralgia, traumatic hemorrhage.
The present invention compared with prior art, has the advantages that
Chinese medicine and western medicine compound preparation of the present invention has effect of sedation-analgesia, anti-cancer and detumescence, hard masses softening and resolving, to treatment lymphoma There is significant curative effect, and taking convenience, quick result, good absorbing effect, no dependence, without any side effects, through clinic Checking, has fabulous therapeutic effect, it is possible to effectively improve body immunity to lymphoma.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine and western medicine compound preparation effective ingredient of the present invention forms and weight is:
Chlorambucil 0.18g, dexamethasone 0.28g, Acetylmidecamycin 0.8g, prednisone 0.38g, methotrexate 0.09g, Membrana Follicularis ovi 23g, tibetan woodbetony flower 22g, Pu 22g, Radix Primulae sieboldii 21g, Adiantum capillus-junosis Rupr. 20g, Cortex ulmi pumilae 20g, pod 19g, Exocarpium Citri Grandis 19g, Folium et Caulis Indigoferae Tinctoriae 19g, Herba Begoniae Crassirostris 18g, Herba Erigerontis Annui 18g, Fructus Hippophae 17g, Herba Selaginellae Doederleinii 16g.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, the extraction process including following western medicine composition walks Rapid:
(1) Western medicine chlorambucil, dexamethasone and methotrexate are mixed in proportion put into medicinal cupping, stir with blender Mix uniformly, put into after 70 DEG C of baking oven is dried and cool down, grind to form fine powder, standby；
(2) Western medicine Acetylmidecamycin and prednisone are put into container, add the ethanol of 1～2 times amount, dilution, be placed in With 5～8 DEG C of temperature oven drying at low temperatures in microwave dryer, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put into pulverizer is ground into mixed powder, standby.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, the extraction process including following Chinese medicine ingredients walks Rapid:
(1) by Chinese medicine Membrana Follicularis ovi, tibetan woodbetony flower, Pu, Radix Primulae sieboldii, Adiantum capillus-junosis Rupr., pod, Exocarpium Citri Grandis, Folium et Caulis Indigoferae Tinctoriae, red Herba Lobeliae Chinensis, Herba Erigerontis Annui, Fructus Hippophae and Herba Selaginellae Doederleinii are mixed in proportion puts into container, adds the distilled water of 5～8 times amount, heated and boiled 2 ～3 hours, to extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby With；
(2) Chinese medicine Cortex ulmi pumilae is put into container, carry out pulverization process, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put in super micron mill, be ground into 0.1～10 μm volumes The mixed powder that the micron particles of mean diameter and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, standby With；
(4) mixed powder that above-mentioned steps (3) is obtained adds relative to the quality 3 of described mixed powder～5 times Determining alcohol is the ethanol of 60%～70%, stirring and dissolving obtain ethanol solution, by ethanol solution under conditions of 5 DEG C～10 DEG C quiet Put 24～36 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and Put at this in super micron mill and pulverize 30～50 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and grain Footpath is less than the mixed powder of the nano-scale particle composition of 0.1 μm volume average particle size, standby.
A kind of preparation method treating lymphadenomatous Chinese medicine and western medicine compound preparation, described mixes Western medicine mixed powder and Chinese medicine Powder mixes, and after stirring, loads capsule shells, makes capsule, obtain described treatment lymphadenomatous Chinese medicine and western medicine compound recipe Preparation.
Usage and dosage: oral, three times a day, each 1 time of morning, noon and afternoon, each 1 (every 0.5g), warm water delivery service；Within 9 days, it is 1 The individual course for the treatment of, can fully recover 3～5 courses for the treatment of, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material of Chinese medicine and western medicine compound preparation effective ingredient of the present invention forms and weight is:
Chlorambucil 0.15g, dexamethasone 0.2g, Acetylmidecamycin 0.6g, prednisone 0.25g, methotrexate 0.06g, Membrana Follicularis ovi 19g, tibetan woodbetony flower 18g, Pu 18g, Radix Primulae sieboldii 17g, Adiantum capillus-junosis Rupr. 16g, Cortex ulmi pumilae 16g, pod 15g, Exocarpium Citri Grandis 15g, Folium et Caulis Indigoferae Tinctoriae 15g, Herba Begoniae Crassirostris 14g, Herba Erigerontis Annui 14g, Fructus Hippophae 13g, Herba Selaginellae Doederleinii 12g.
The Chinese medicine and western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of Chinese medicine and western medicine compound preparation effective ingredient of the present invention forms and weight is:
Chlorambucil 0.12g, dexamethasone 0.12g, Acetylmidecamycin 0.4g, prednisone 0.12g, methotrexate 0.03g, Membrana Follicularis ovi 15g, tibetan woodbetony flower 14g, Pu 14g, Radix Primulae sieboldii 13g, Adiantum capillus-junosis Rupr. 12g, Cortex ulmi pumilae 12g, pod 11g, Exocarpium Citri Grandis 11g, Folium et Caulis Indigoferae Tinctoriae 11g, Herba Begoniae Crassirostris 10g, Herba Erigerontis Annui 10g, Fructus Hippophae 9g, Herba Selaginellae Doederleinii 8g.
The Chinese medicine and western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of Chinese medicine and western medicine compound preparation effective ingredient of the present invention forms and weight is:
Chlorambucil 0.1g, dexamethasone 0.1g, Acetylmidecamycin 0.3g, prednisone 0.1g, methotrexate 0.02g, Membrana Follicularis ovi 11g, tibetan woodbetony flower 10g, Pu 10g, Radix Primulae sieboldii 9g, Adiantum capillus-junosis Rupr. 8g, Cortex ulmi pumilae 8g, pod 7g, Exocarpium Citri Grandis 7g, Folium et Caulis Indigoferae Tinctoriae 7g, Herba Begoniae Crassirostris 6g, Herba Erigerontis Annui 6g, Fructus Hippophae 5g, Herba Selaginellae Doederleinii 4g.
The Chinese medicine and western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.Toxicity Test:
1, acute toxicity test:
(1) choose mice 40, male and female half and half, body weight 21～38g, carry out acute toxicity test.Mice is randomly divided into two Group, i.e. experimental group and matched group, fasting 12 hours before experiment；
(2) the Chinese medicine and western medicine compound preparation of the present invention is taken 1 to be dissolved in 10ml water, standby；
(3) take and step (2) normal saline, standby；
(4) the Chinese medicine and western medicine compound preparation solution of the present invention in step (2) is taken by the perfusion amount pair that gavage volume is 5ml/kg 20 mices of experimental group carry out perfusion；Within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and The toxic reaction of record mice and death toll；
(5) normal saline in step (3) is taken by matched group 20 of the perfusion amount that gavage volume is 5ml/kg Mice carries out perfusion；Within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and records the poison of mice Property reaction and death toll；
Test result indicate that: compare with matched group, after experimental group is administered, mice has no notable difference, tests Continuous Observation 14 My god, mouse systemic situation, diet, drinking-water, body weight increase the most normal.
2, long term toxicity test:
Choose mice 40, male and female half and half, body weight 21～38g, carry out long term toxicity test.By the Chinese and Western recurrence due to taking drug of the present invention Square preparation takes 1 and is dissolved in 10ml water, carries out mice perfusion, every day 2 times by the perfusion amount that gavage volume is 5ml/kg, connects After continuous medication 15 weeks, drug withdrawal 3 weeks, carries out laboratory observation.
Test result indicate that: Chinese medicine and western medicine compound preparation of the present invention is to the hair of mice, behavior, defecation, body weight, internal organs weight The indexs such as amount, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not find difference change, histology Inspection result shows, Organs of Mice is the most all without substantially changing；Illustrate that Chinese medicine and western medicine compound preparation of the present invention is to mice long-term prescription Rear toxicity is little, does not also have difference reaction, application safety after drug withdrawal.
Clinical data:
One, case selection:
As treating lymphadenomatous Chinese medicine and western medicine compound preparation, select the Lymphoma 195 example clinical observation made a definite diagnosis, patient Be randomly divided into treatment group, control group A and matched group B tri-groups, treatment group 65 example, wherein male 32 example, women 33 example, the age 24～ 57 years old, 40.5 years old mean age, the course of disease 9 days～7 months；Control group A 65 example, wherein male 33 example, women 32 example, the age 23～ 56 years old, 39.5 years old mean age, the course of disease 6 days～7 months；Matched group B65 example, wherein male 31 example, women 34 example, the age 22～ 59 years old, 40.5 years old mean age, the course of disease 8 days～7 months.
Treatment group, control group A and the course of disease of tri-groups of cases of matched group B, degrees of symptoms are basically identical, without significance difference Different, there is comparability.
Two, medicament selection:
Treatment group uses Chinese medicine and western medicine compound preparation of the present invention, oral, three times a day, each 1 time of morning, noon and afternoon, each 1 (every 0.5g), warm water delivery service；Within 9 days, being 1 course for the treatment of, can fully recover 3～5 courses for the treatment of, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Control group A takes FUFANG BANMAO JIAONANG, oral, one time 3,2 times on the one.
Matched group B uses Xiaoaiping injection, intramuscular injection one time 2～4ml, 1～2 time on the one；Or follow the doctor's advice.Vein drips Note and instil after 5% or 10% glucose injection dilution, one time 20～100ml, once-a-day；Or follow the doctor's advice.
Three, Outcome measure:
Curing: lump disappears, symptom and sign disappears, and physical recovery is healthy.Effective: lump is obviously reduced, symptom and sign is bright Aobvious alleviation, health is clearly better.Effective: lump has reduced, symptom and sign has been alleviated, and health has taken a turn for the better.Invalid: to pass through After treatment, above-mentioned symptom is without improving, and has the trend of deterioration.
Four, therapeutic outcome:
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than control group A and matched group B.
Five, model case:
1, Tang, female, 52 years old.Patient increases because of neck region lump, admission examination, is diagnosed as lymphoma, treats a period of time Neck region lump has no disappearance, recommends by doctor, takes Chinese medicine and western medicine compound preparation of the present invention treatment, after taking 1 course for the treatment of, cervical region Lump has disappeared, and after continuing to take 3 courses for the treatment of, neck region lump disappears, and the state of an illness is fully recovered, and follows up a case by regular visits to have no recurrence after 1 year.
2, journey, man, 37 years old.Patient's cervical region has lump, admission examination, is diagnosed as lymphoma in early days, uses multiple method Treatment, therapeutic effect is general, recommends by doctor, takes Chinese medicine and western medicine compound preparation of the present invention treatment, after taking 1 course for the treatment of, swollen Block is obviously reduced, and after taking 4 courses for the treatment of, lump disappears, and every laboratory indexes is all normal, and recovery from illness is followed up a case by regular visits to after half a year without recurrence.
3, desolate certain, female, 41 years old.Patient has pulmonary tuberculosis and tuberculosis of cervical lymph nodes medical history, non-regular treatment, occurs discomfort afterwards Symptom, removes examination in hospital, is diagnosed as lymphoma, and doctor gives Chinese medicine and western medicine compound preparation of the present invention treatment, after taking 1 course for the treatment of, Symptom makes moderate progress, and after taking 2 courses for the treatment of, symptom is obviously improved, and after continuing to take 2 courses for the treatment of, symptom all disappears, and health is extensive Multiple normal, recovery from illness, follow up a case by regular visits to not recur so far.
4, Shen, man, 29 years old.The most accessible limitation differed in size protuberance property enclosed mass occurs after patient's ear, painless, enter Institute checks, is diagnosed as lymphoma, and doctor gives Chinese medicine and western medicine compound preparation of the present invention treatment, and after taking 1 course for the treatment of, lump has contracted Little, after taking 2 courses for the treatment of, lump is obviously reduced, and after continuing to take 1 course for the treatment of, lump disappears, recovery from illness, follows up a case by regular visits to without multiple after 1 year Send out.
5, Deng, female, 35 years old.Patient's cervical lymph node enlargement, with the symptoms such as more than, rapid breathing of coughing, goes to hospital Checking, be diagnosed as lymphoma, doctor gives Chinese medicine and western medicine compound preparation of the present invention treatment, and after taking 1 course for the treatment of, symptom substantially subtracts Gently, after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after half a year.
6, Dong, man, 44 years old.Having lump, low grade fever under patient's neck, health is weak, removes examination in hospital, is diagnosed as lymphoma, Doctor gives Chinese medicine and western medicine compound preparation of the present invention treatment, and after taking 1 course for the treatment of, lump has reduced, and symptom makes moderate progress, and takes After 2 courses for the treatment of, lump is obviously reduced, and symptom is obviously improved, and after continuing to take 1 course for the treatment of, lump and symptom all disappear, and fully recover from an illness More, follow up a case by regular visits to not recur so far.
Last it is noted that the above, it is only presently preferred embodiments of the present invention, is not that the present invention is made it The restriction of its form, every without departing from technical solution of the present invention content, any repaiied according to do in the application range of the present invention Change, equivalent and improvement etc., still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. treat lymphadenomatous Chinese medicine and western medicine compound preparation for one kind, it is characterised in that: make described Chinese medicine and western medicine compound preparation and effectively become The raw material divided forms and parts by weight are:
Chlorambucil 0.1～0.2 part, dexamethasone 0.1～0.3 part, Acetylmidecamycin 0.3～0.9 part, prednisone 0.1 ～0.4 part, methotrexate 0.02～0.1 part, Membrana Follicularis ovi 11～27 parts, tibetan woodbetony flower 10～26 parts, Pu 10～26 parts, cherry Grass roots 9～25 parts, Adiantum capillus-junosis Rupr. 8～24 parts, Cortex ulmi pumilae 8～24 parts, pod 7～23 parts, Exocarpium Citri Grandis 7～23 parts, Folium et Caulis Indigoferae Tinctoriae 7～ 23 parts, Herba Begoniae Crassirostris 6～22 parts, Herba Erigerontis Annui 6～22 parts, Fructus Hippophae 5～21 parts, Herba Selaginellae Doederleinii 4～20 parts.
One the most according to claim 1 treats lymphadenomatous Chinese medicine and western medicine compound preparation, it is characterised in that: make described in The raw material of compound Western medicine preparation effective ingredient forms and parts by weight are:
Chlorambucil 0.12～0.18 part, dexamethasone 0.12～0.28 part, Acetylmidecamycin 0.4～0.8 part, prednisone 0.12～0.38 part, methotrexate 0.03～0.09 part, Membrana Follicularis ovi 15～23 parts, tibetan woodbetony flower 14～22 parts, Pu 14～ 22 parts, Radix Primulae sieboldii 13～21 parts, Adiantum capillus-junosis Rupr. 12～20 parts, Cortex ulmi pumilae 12～20 parts, pod 11～19 parts, Exocarpium Citri Grandis 11～ 19 parts, Folium et Caulis Indigoferae Tinctoriae 11～19 parts, Herba Begoniae Crassirostris 10～18 parts, Herba Erigerontis Annui 10～18 parts, Fructus Hippophae 9～17 parts, Herba Selaginellae Doederleinii 8～16 parts.
One the most according to claim 1 treats lymphadenomatous Chinese medicine and western medicine compound preparation, it is characterised in that: make described in The raw material of compound Western medicine preparation effective ingredient forms and parts by weight are:
Chlorambucil 0.15 part, dexamethasone 0.2 part, Acetylmidecamycin 0.6 part, prednisone 0.25 part, methotrexate 0.06 part, Membrana Follicularis ovi 19 parts, tibetan woodbetony flower 18 parts, Pu 18 parts, Radix Primulae sieboldii 17 parts, Adiantum capillus-junosis Rupr. 16 parts, Cortex ulmi pumilae 16 Part, pod 15 parts, Exocarpium Citri Grandis 15 parts, Folium et Caulis Indigoferae Tinctoriae 15 parts, Herba Begoniae Crassirostris 14 parts, Herba Erigerontis Annui 14 parts, Fructus Hippophae 13 parts, Herba Selaginellae Doederleinii 12 parts.
4. as described in any one of claims 1 to 3, treat a preparation method for lymphadenomatous Chinese medicine and western medicine compound preparation, its feature It is: include the extraction process step of following western medicine composition:
(1) Western medicine chlorambucil, dexamethasone and methotrexate are mixed in proportion put into medicinal cupping, with blender stirring all Even, put into after 70 DEG C of baking oven is dried and cool down, grind to form fine powder, standby；
(2) Western medicine Acetylmidecamycin and prednisone are put into container, add the ethanol of 1～2 times amount, dilution, be placed in microwave With 5～8 DEG C of temperature oven drying at low temperatures in dehydrator, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put into pulverizer is ground into mixed powder, standby.
5. as described in any one of claims 1 to 3, treat a preparation method for lymphadenomatous Chinese medicine and western medicine compound preparation, its feature It is: include the extraction process step of following Chinese medicine ingredients:
(1) by Chinese medicine Membrana Follicularis ovi, tibetan woodbetony flower, Pu, Radix Primulae sieboldii, Adiantum capillus-junosis Rupr., pod, Exocarpium Citri Grandis, Folium et Caulis Indigoferae Tinctoriae, red one side of something Lotus, Herba Erigerontis Annui, Fructus Hippophae and Herba Selaginellae Doederleinii are mixed in proportion puts into container, adds the distilled water of 5～8 times amount, heated and boiled 2～3 Hour, to extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby；
(2) Chinese medicine Cortex ulmi pumilae is put into container, carry out pulverization process, grind to form fine powder, standby；
(3) fine powder obtained by above-mentioned steps (1) and (2) is put in super micron mill, be ground into 0.1～10 μm volumes average The mixed powder that the micron particles of particle diameter and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, standby；
(4) add relative to the quality 3 of described mixed powder～5 times in mixed powder above-mentioned steps (3) obtained is pure and strong Degree is the ethanol of 60%～70%, stirring and dissolving obtain ethanol solution, ethanol solution is stood under conditions of 5 DEG C～10 DEG C 24～ 36 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this Enter in super micron mill and pulverize 30～50 minutes, it is thus achieved that micron particles and the particle diameter of 0.1～10 μm volume average particle size are less than The mixed powder of the nano-scale particle composition of 0.1 μm volume average particle size, standby.
6. according to claim 4 or claim 5, treat the preparation method of lymphadenomatous Chinese medicine and western medicine compound preparation, its feature It is: described Western medicine mixed powder and Chinese medicine mixed powder are mixed, after stirring, loads capsule shells, make capsule, Obtain described treatment lymphadenomatous Chinese medicine and western medicine compound preparation.
CN201610701456.XA 2016-08-22 2016-08-22 One treats lymphadenomatous Chinese medicine and western medicine compound preparation and preparation method Pending CN106074913A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491268A (en) * 2015-01-09 2015-04-08 田曼霖 Traditional Chinese medicine capsule for treating lymphoma and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491268A (en) * 2015-01-09 2015-04-08 田曼霖 Traditional Chinese medicine capsule for treating lymphoma and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
梁昆等: "中西医结合治疗中老年伯基特淋巴瘤方案探讨", 《光明中医》 *

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