CN106074896A - A kind of medicinal preparation for oral administration treating prolonged lochia and preparation method thereof - Google Patents

A kind of medicinal preparation for oral administration treating prolonged lochia and preparation method thereof Download PDF

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CN106074896A
CN106074896A CN201610464298.0A CN201610464298A CN106074896A CN 106074896 A CN106074896 A CN 106074896A CN 201610464298 A CN201610464298 A CN 201610464298A CN 106074896 A CN106074896 A CN 106074896A
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propolis
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周军
金萍
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Abstract

The present invention is to disclose a kind of medicinal preparation for oral administration treating prolonged lochia, take off and state the primary raw material of weight proportion and be prepared from: Stigma Croci 10 20 parts, Fructus Mori 35 parts, Radix Cyathulae 5 10 parts, Radix Ginseng 48 parts, fish head 5 15 parts, Ramulus Cinnamomi 6 10 parts, Fructus Fici 15 25 parts, Herba Ecliptae 38 parts, the Radix Astragali 47 parts, 15 25 parts of Semen Persicae, propolis 38 parts.Function cures mainly: women's qi-deficiency type in puerperal lochiorrhea.Disease is seen: lochia, and dripping urine endlessly is not healed, and color is light red, and amount is many, and matter is thin, odorless, continuous and dull pain in the abdomen, few abdomen tenesmus, breathes hard, and tired mind, pale complexion is simple and unadorned, pale tongue, and tongue is normal, and moderate pulse is weak.

Description

A kind of medicinal preparation for oral administration treating prolonged lochia and preparation method thereof
Technical field
The invention discloses a kind of medicinal preparation for oral administration, a kind of medicinal preparation for oral administration treating prolonged lochia and preparation method. The invention belongs to traditional Chinese medicine field.
Background technology
Lochia refers to, with uterine decidualization, discharge containing the tissue transvaginal such as blood, downright bad decidua, be referred to as disliking Dew, this be puerpera in puerperal clinical manifestation, belong to physiological change.Lochia has a smell of blood, but odorless, its color and interior Tolerant time to time change, general persistently 4～6 weeks, total amount was 250ml～500ml.As still having more lochia beyond the above-mentioned time Discharge, referred to as prolonged lochia.
Classification: healthy lochia is different according to color, content and time, is classified as three kinds: 1. lochia rubra: because of containing big Amount blood is gained the name, and color is scarlet, and amount is many, sometimes has little clot.Volume erythrocyte, downright bad decidua and a small amount of fetal membrane is seen under mirror.Courageous and upright Lochia continues 3～4.Hemorrhage gradually decreasing, serosity increases, and is changed into lochia serosa.2. lochia serosa: because the serosity containing volume obtains Name, color is light red.See more downright bad decidua tissue, uterine cavity transudate, Ovulation prediction, a small amount of erythrocyte and leukocyte under mirror, and have Antibacterial.Lochia serosa continues about 10 days, and serosity gradually decreases, leukocytosis, becomes lochia alba.
3. lochia alba: because containing a large amount of leukocyte, color and luster is gained the name more in vain, and matter is sticky.See under mirror that a large amount of leukocyte, necrosis are sloughed off Membrane tissue, epidermis cell and antibacterial etc..Lochia alba lasts about 3 weeks totally.Although each puerpera has lochia, but everyone discharges Amount be different, average total amount is up to 500～1000 milliliters.The time that each puerpera persistently arranges dew is the most different, produces normally Woman is it is generally required to 2～4 weeks, and minority puerpera can continue 1～2 months.When child sucks the breast, suck nipple, reflection temper can be caused Palace is shunk, and the beneficially lochia in cavity of uterus is discharged.
Prolonged lochia clinical manifestation: 1. tissue substance residual: can be relatively big because of gestation month, or uterine malformation, uterus muscle The reasons such as tumor, it is possible to because of operator's lack of skill, cause gestation group fabric the most fully erased, cause portion of tissue thing residual Stay in uterine cavity.Now except prolonged lochiorrhea, few time also many during amount of bleeding, inner clip clot, and with a burst of stomachache.2. uterine cavity Infection can be because of bath in a tub after puerperal or artificial abortion, or sanitary towel is unclean, or sexual life the most at once after puerperal or artificial abortion, it is possible to because of hands: art Operator's reasons such as imprecision of sterilizing cause uterine cavity to infect.Now lochia frowziness, abdominal part has tenderness, and with heating, has a blood test As visible total white blood cells raises.3. uterine inertia: can have a rest very well because failing puerperal, or how sick physical weakness is usually, or raw Produce or Cesarean operation overlong time, cause uterine inertia, lochia.Owing to Symptoms differs, treatment phase the most not to the utmost With, remind and go to hospital to ask doctor to search the cause of disease of lochiorrhea in time, and treat for the cause of disease.
In the method for existing Chinese medicine prolonged lochia, application publication number CN 103599482 B(applies for Numbers 201310580614.7) patent discloses a kind of Chinese medicine treating lochiorrhea, it is characterised in that: its each raw material components Weight proportion be: Hypericum przewalskii Maxim. 13-17, Pollen Typhae carbon 13-17, Herba Ecliptae 1-5, Fructus Jujubae 13-17, Radix Curcumae 10-14, Cladonia alpestris (L.) Rabenh. 6- 10, incense burner grass 1-5, Cortex Eucommiae 6-10, Radix Glycyrrhizae 6-10, fresh rehmannia charcoal 4-8, Cacumen Platycladi preparata 6-10, Herba Agrimoniae 10-14, Flos Campsis 4-8, strand Stock blue 10-14, Radix Paeoniae Rubra 4-8.Authorization Notice No. CN 103349766 B(application number 201310286380.5) patent open A kind of pharmaceutical composition for prolonged lochia, it is prepared by the raw material of following weight proportioning:
Herba Leonuri 25 parts, Cortex Albiziae 25 parts, Arillus Longan 20 parts, 20 parts of Fructus Mori, 20 parts of Flos Carthami, Herba Patriniae 19 parts, sarranine Spend 18 parts, the Radix Aucklandiae 18 parts, 16 parts of Poria, Rhizoma Zingiberis Preparatum 16 parts, Pollen Typhae 15 parts, Rhizoma Cyperi 15 parts, Radix Trichosanthis 15 parts, Cortex Phellodendri 13 Part, Fructus Lycii 13 parts, Fructus Liquidambaris 10 parts, the Radix Astragali 10 parts, Rhizoma Chuanxiong 10 parts, Ramulus Cinnamomi 8 parts, Rhizoma Curcumae 8 parts,
Ramulus Cinnamomi 7 parts, 5 parts of Auricularia, 4 parts of Fructus Hordei Germinatus, Semen Vaccariae 3 parts, 1 part of Radix Glycyrrhizae.
Along with the development of China's Chinese medicine, on treatment prolonged lochia, during people appreciate gradually Medicine treatment prolonged lochia side effect is little, bears painful little advantage, and the traditional Chinese medical science improves attention organic conception, pay attention to Synthetic Reason, payes attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, is improving the advantage more demonstrating treatment by Chinese herbs prolonged lochia in effect.Chinese medicine has treatment to produce Endocrine mended in rear lochiorrhea, tune, nourish skin care, supplement trace element needed for health, the special efficacy of hard masses softening and resolving, Er Qiezuo With lasting, treating both the principal and secondary aspects of a disease, have no side effect and efficacy consolidation, be difficult to recurrence.
Summary of the invention
For the present situation of existing intestinal microbial population, an object of the present invention is to provide the oral for the treatment of prolonged lochia Medicament, has easily operation, feature evident in efficacy, with low cost.Another object is just to provide the preparation side of above-mentioned medicinal preparation for oral administration Method.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
The medicinal preparation for oral administration for the treatment of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from: Stigma Croci 10-20 Part, Fructus Mori 3-5 part, Radix Cyathulae 5-10 part, Radix Ginseng 4-8 part, fish head 5-15 part, Ramulus Cinnamomi 6-10 part, Fructus Fici 15-25 part, ink Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 3-8 part, Radix Astragali 4-7 part, Semen Persicae 15-25 part, propolis 3-8 part.
Treatment prolonged lochia medicinal preparation for oral administration, preferred version is, take off state weight proportion primary raw material preparation and Become: Stigma Croci 13-18 part, Fructus Mori 3.5-4.5 part, Radix Cyathulae 6-9 part, Radix Ginseng 5-7 part, fish head 8-13 part, Ramulus Cinnamomi 7-9 part, Fructus Fici 18-23 part, Herba Ecliptae 4-7 part, Radix Astragali 5-6 part, Semen Persicae 18-23 part, propolis 4-7 part.
Treatment prolonged lochia medicinal preparation for oral administration, preferred version is, take off state weight proportion primary raw material preparation and Become: Stigma Croci 15 parts, Fructus Mori 4 parts, Radix Cyathulae 7.5 parts, Radix Ginseng 6 parts, fish head 10 parts, Ramulus Cinnamomi 8 parts, Fructus Fici 20 parts, ink drought 6 parts of lotus, the Radix Astragali 5.5 parts, 20 parts of Semen Persicae, propolis 5.5 parts.
The preparation method of above-mentioned medicinal preparation for oral administration, is characterized in that, step is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils the 20-40 second, It is placed at shady and cool ventilation and dries in the air to 40-50 DEG C of addition Semen Persicae, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 3%-5% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Point From time use nylon wire make sack, wine liquid and distiller grains are together poured in sack, bag mouth are tightened, press slag by hand, Standing 3-7 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 80-120 mesh sieve is crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 18-26 minute, filters, and filtrate stands and within 6-8 hour, takes supernatant, filtering residue Parch is crisp, and grinding to form smalls, to cross 120-160 mesh sieve stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.2-0.6 times of mixture, will Step (4) gained filtrate is placed in transparent container, and add water the mixture configured, mixed dynamic uniform, instills after melting completely Step (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Above-mentioned preparation method, step (1) turns big fire and boils the 25-35 second, is placed at shady and cool ventilation and dries in the air to 43-48 DEG C of addition Fructus Persicae Core (preferably, turns big fire and boils 30 seconds, be placed at shady and cool ventilation and dry in the air to 45 DEG C of addition Semen Persicaes).
Above-mentioned preparation method, step (2) is pressed slag by hand, is stood 4-6 days (preferably, press slag by hand, stand 5 days).
Above-mentioned preparation method, step (3) grinds to form smalls and crosses that 90-110 mesh sieve is stand-by (preferably, to grind to form smalls and cross 100 Mesh sieve is stand-by).
Above-mentioned preparation method, step (4) adds the light salt brine of raw material gross weight 5-7 times and (preferably, adds raw material gross weight The light salt brine of 6 times).
Above-mentioned preparation method, step (4) big fire is boiled, and turns slow fire boiling 20-24 minute, filters, and filtrate stands 6.5-7.5 Hour take supernatant (preferably, big fire is boiled, and turns slow fire boiling 22 minutes, filters, and filtrate stands and takes supernatant in 7 hours).
Above-mentioned preparation method, step (5) adds the dextrin of 0.3-0.5 times of mixture and (preferably, adds 0.4 times of mixture Dextrin).
The pharmacological effect of each crude drug is respectively as follows:
Stigma Croci: for the stigma of Rhizoma Iridis Tectori crocus plant Stigma Croci.Composition: stigma is containing volatile oil component more than 30.Also containing color Element class: saffron glucoside, crocetin, really glycosides-6 '-O-Stigma Croci acyl group 1 ' '-O-β-D-Glucose glycosides fat；Sterols: vegetable oil Sterol, stigmasterol etc..Triterpenes: ursolic acid, oleanolic acid；Fatty acid: Palmic acid, palmitoleic acid, oleic acid, linoleic acid, sub- Fiber crops acid；Carotenoids: octahydro lycopene, phytofluene, etc..The property of medicine: sweet, flat.GUIXIN, Liver Channel.Function cures mainly: invigorate blood circulation Blood stasis dispelling, dissipating blood stasis unwinds.Cure mainly dysmenorrhea, amenorrhea, menoxenia, post partum longtime lochia, enclosed mass pain in abdomen, injury from falling down, melancholy Painful abdominal mass is vexed, and palpitation with fear, epidemic febrile disease sends out speckle, measles.
Fructus Mori: for the dry fruit ear of Moraceae Mulberry plant Mulberry.Composition: fruit ear is containing vitamin B1, B2 and carotene；Its The fatty acid of lipid is mainly linoleic acid, oleic acid, palmitic acid, stearic acid, still has a small amount of octanoic acid, n-nonanoic acid, capric acid etc..The property of medicine: sweet, Sour, cold.Return sweet, kidney channel.Function cures mainly: nourishing YIN and benefiting blood, promotes the production of body fluid, intestine moistening.Cure mainly having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence, Tinnitus, early whitening of beard and hair, insomnia, quench one's thirst, the soreness of waist, dryness of the intestine constipation, tinea alba.
Radix Cyathulae: for the root of Amaranthaceae Radix Cyathulae platymiscium Radix Cyathulae.Composition: root contains β-ecdysterone, cyasterone, polysaccharide And Trace Element Titanium etc..The property of medicine: hardship sweet, micro-, flat.Return liver, kidney channel.Function cures mainly: promoting blood circulation to remove blood stasis, expelling wind and removing dampness.Cure mainly blood stasis Amenorrhea, difficult labour, retention of placenta, curing postpartum bleeding stomachache, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury.
Radix Ginseng: effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.Cure mainly: weak body and prostration, cold extremities arteries and veins Micro-, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, the heart Originality is suffered a shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and cause after losing blood Shock, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Controlling impairment caused by overstrain deficient, lack of appetite, asthenia, regurgitation tells food, and lingering diarrhea of defecating, void is coughed Dyspnea with rapid and short breath, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, The card of all qi-blood-body fluid deficiencies.
Fish head: fish head have nutrition height, features good taste, rich in the lecithin of needed by human and unsaturated fatty acid.To reduction Blood fat, brain-strengthening and slow down aging are beneficial, contribute to strengthening male's sexual, have reducing blood fat, brain-strengthening and slow down aging Place etc..
Ramulus Cinnamomi: Chinese crude drug Ramulus Cinnamomi is the dry twig of Cortex Cinnamomi, typically gathers in spring, summer, directly dries after going disleaf Or section dry.The pungent temperature of Ramulus Cinnamomi, can cold-dispelling, cold, fever with chills etc. can be treated.Its nature and flavor acrid, sweet, warm, enter Lung, the heart, bladder warp, be to cure mainly the drugs for dispelling internal cold that interior cold is conventional, have complement sun, promoting blood circulation, effect of warming the spleen and stomach, normal and invigorating the liver and kidney Medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, with other drugs for dispelling internal cold compatibility treatment coldness and pain in the epigastrium, Arthralgia due to cold lumbago, has significantly analgesia and the effect of anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine such as menthocamphorate, rheumatism oil Deng all containing cassia oil composition.Major function: Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Main air is trembled with fear table Card；Arthralgia due to cold-dampnes；Extreme cold of the limbs；Amenorrhea dysmenorrhea；Lump in the abdomen lumps；The thoracic obstruction；Cardiopalmus；Phlegm retention；Dysuria.For anemofrigid cold, Coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Cure mainly " Sullfortrone " leprous its main component I.e. cassia oil, other side-product of Cortex Cinnamomi such as Ramulus Cinnamomi, Fructus cinnamomi japonici, Fructus cinnamomi immaturus, osmanthus cup etc. have different pharmacological actions, in Chinese medicine widely Application.
Fructus Fici: invigorating the stomach and promoting bowel movement, subduing swelling and detoxicating.Control enteritis, dysentery, constipation, hemorrhoid, have sore throat, ulcerative carbuncle scabies, throat, Appetizing anthelmintic.For inappetence, abdominal distention, constipation due to hemorrhoids, dyspepsia, hemorrhoid, proctoptosis, diarrhoea, hypogalactia, throat Swell and ache, hematodiarrhoea, the disease such as cough ant phlegm.
Herba Ecliptae: abnormal smells from the patient: (careless) sweet in the mouth acid, cool in nature, enter Liver and kidney two warp, nontoxic.Cure mainly: nourishing the liver and kidney, cooling blood for hemostasis, can Control various haematemesis, the disease such as enterorrhagia.Smashing juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.
The Radix Astragali: modern medicine study shows, the Radix Astragali have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, Blood pressure lowering and wide antibacterial action.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.Yellow Stilbene can not only coronary artery dilator, improve blood supply of cardiac muscle, improve immunologic function, and can the process of delaying cell aging.Yellow Stilbene instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc..
Semen Persicae: for rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) dry mature seed of Franch..Gather after fruit maturation, remove sarcocarp and nucleocapsid, take out seed, dry.The whole nation Various places are generally cultivated.There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess Acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Propolis: abundant contained by propolis and the bioactive substance of uniqueness so that it is there is antibacterial, antiinflammatory, antipruritic, antioxygen Change, strengthen the several functions such as immunity, blood sugar lowering, blood fat reducing, antitumor, human body is had medical treatment, health-care effect widely, Become the focus of various countries' scientific research, and become emerging health product and extremely praise highly.Antibacterial action.Propolis energy sterilizing, sterilize, disappear Malicious, antibacterial, mildew-resistant, anticorrosion, solve the defect that single microorganism is only worked by antibiotic, and be free from side effects.Daily Dermatosis is had good therapeutic effect by life.Antivirus action.Propolis is natural antiviral substance, to multiple virus all There are the strongest suppression and killing action.Antioxidation.Propolis is referred to as antioxidant and free radical scavenger, it is possible to the most clear Except the excess activated oxygen produced because of the bad life habits such as fat, overworked, environmental pollution, smoking and extraneous factor and freedom The refuses such as base.Enhancing immunity effect.The immune system of human body is easily infracting by virus, and propolis can strengthen body immunity, Strengthen the ability of human body opposing virus infraction.Antitumaous effect.Domestic and international substantial amounts of research shows, propolis has pressing down cancer anticancer aspect Well effect.Promote cell regeneration effect.Propolis can accelerate the healing of tissue regeneration and wound.Effects of beautification and nourishing face.Honeybee Glue can decompose pigment, calm down wrinkle, delaying senility etc., is women cosmetic good merchantable brand.Analgesic activity.Propolis is in terms of analgesia Also there is good effect.Prophylaxis of tumours.Containing abundant cancer-resisting substance in propolis, research proves, cancer patient is taking propolis After, can reduce cancerous cell and chemotherapy can be alleviated, side effect that radiotherapy causes.Resisting hypertension.The patient suffering from hypertension takes continuously With containing very many Flavonoid substances and there is the propolis of very strong anti-oxidation ability, it is possible not only to reduce lipid peroxidation confrontation blood The harm of pipe, prevents sclerosis of blood vessels, and can also be effectively reduced the content of triglyceride, reduces platelet aggregation, improves micro- Circulation, can reduce too high blood pressure, prevents the generation of unexpected thing.Thus, middle-aged and elderly people, particularly hypertension, heart disease, Arteriosclerosis patient, usually takes propolis, and good health and a long life are quite had benifit.
Compared with prior art, the technical advantage of the present invention is embodied in:
1, medical material used by the present invention does not has toxicity, and the health mechanism for sufferer does not results in damage, and audient crowd is wide, is suitable for clothes With.
2, bright the used medical material relative inexpensiveness of this law, the compared with prior art bright obtained medicinal preparation for oral administration of this law Cost is more
Add cheap.
3, the improvement effect of the present invention is compared to prior art, improves effect and becomes apparent from, and the cycle of improving is short, the most substantially Sequela, can be with life-time service.
4, function cures mainly: women's qi-deficiency type in puerperal lochiorrhea.Disease is seen: lochia, and dripping urine endlessly is not healed, blood Color is light red, and amount is many, and matter is thin, odorless, continuous and dull pain in the abdomen, few abdomen tenesmus, breathes hard, and tired mind, pale complexion is simple and unadorned, body of the tongue Light, tongue is normal, and moderate pulse is weak.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 treats the medicinal preparation for oral administration of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 10g): Stigma Croci 10 parts, Fructus Mori 3 parts, Radix Cyathulae 5 parts, Radix Ginseng 4 parts, fish head 5 parts, Ramulus Cinnamomi 6 parts, Fructus Fici 15 parts, ink Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 3 parts, the Radix Astragali 4 parts, 15 parts of Semen Persicae, propolis 3 parts.
The medicinal preparation for oral administration preparation process for the treatment of prolonged lochia is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils 20 seconds, is placed in Dry in the air at shady and cool ventilation to 40 DEG C of addition Semen Persicaes, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 3%% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Separate The sack that Shi Caiyong nylon wire makes, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, press slag by hand, quiet Putting 3 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 80 mesh sieves are crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 18 minutes, filters, and filtrate stands and within 6 hours, takes supernatant, and filtering residue parch is crisp Crisp, grinding to form smalls, to cross 120 mesh sieves stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.2 times of mixture, by step (4) in gained filtrate is placed in transparent container, add water the mixture configured, mixed dynamic uniform, instills step after melting completely (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Embodiment 2 treats the medicinal preparation for oral administration of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 15g): Stigma Croci 20 parts, Fructus Mori 5 parts, Radix Cyathulae 10 parts, Radix Ginseng 8 parts, fish head 15 parts, Ramulus Cinnamomi 10 parts, Fructus Fici 25 Part, Herba Ecliptae 8 parts, the Radix Astragali 7 parts, 25 parts of Semen Persicae, propolis 8 parts.
The medicinal preparation for oral administration preparation process for the treatment of prolonged lochia is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils 40 seconds, is placed in Dry in the air at shady and cool ventilation to 50 DEG C of addition Semen Persicaes, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 5% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Separate The sack that Shi Caiyong nylon wire makes, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, press slag by hand, quiet Putting 7 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 120 mesh sieves are crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 26 minutes, filters, and filtrate stands and within 8 hours, takes supernatant, and filtering residue parch is crisp Crisp, grinding to form smalls, to cross 160 mesh sieves stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.6 times of mixture, by step (4) in gained filtrate is placed in transparent container, add water the mixture configured, mixed dynamic uniform, instills step after melting completely (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Embodiment 3 treats the medicinal preparation for oral administration of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 20g): Stigma Croci 13 parts, Fructus Mori 3.5 parts, Radix Cyathulae 6 parts, Radix Ginseng 5 parts, fish head 8 parts, Ramulus Cinnamomi 7 parts, Fructus Fici 18 parts, Herba Ecliptae 4 parts, the Radix Astragali 5 parts, 18 parts of Semen Persicae, propolis 4 parts.
The medicinal preparation for oral administration preparation process for the treatment of prolonged lochia is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils 25 seconds, is placed in Dry in the air at shady and cool ventilation to 43 DEG C of addition Semen Persicaes, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 3% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Separate The sack that Shi Caiyong nylon wire makes, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, press slag by hand, quiet Putting 4 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 90 mesh sieves are crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 20 minutes, filters, and filtrate stands and within 6.5 hours, takes supernatant, filtering residue parch Crisp, grinding to form smalls, to cross 130 mesh sieves stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.3 times of mixture, by step (4) in gained filtrate is placed in transparent container, add water the mixture configured, mixed dynamic uniform, instills step after melting completely (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Embodiment 4 treats the medicinal preparation for oral administration of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 25g): Stigma Croci 18 parts, Fructus Mori 4.5 parts, Radix Cyathulae 9 parts, Radix Ginseng 7 parts, fish head 13 parts, Ramulus Cinnamomi 9 parts, Fructus Fici 23 Part, Herba Ecliptae 7 parts, the Radix Astragali 6 parts, 23 parts of Semen Persicae, propolis 7 parts.
The medicinal preparation for oral administration preparation process for the treatment of prolonged lochia is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils 35 seconds, is placed in Dry in the air at shady and cool ventilation to 48 DEG C of addition Semen Persicaes, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 5% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Separate The sack that Shi Caiyong nylon wire makes, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, press slag by hand, quiet Putting 6 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 110 mesh sieves are crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 24 minutes, filters, and filtrate stands and within 7.5 hours, takes supernatant, filtering residue parch Crisp, grinding to form smalls, to cross 150 mesh sieves stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.5 times of mixture, by step (4) in gained filtrate is placed in transparent container, add water the mixture configured, mixed dynamic uniform, instills step after melting completely (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Embodiment 5 treats the medicinal preparation for oral administration of prolonged lochia, takes off and states the primary raw material of weight proportion and be prepared from (every Part takes 30g): Stigma Croci 15 parts, Fructus Mori 4 parts, Radix Cyathulae 7.5 parts, Radix Ginseng 6 parts, fish head 10 parts, Ramulus Cinnamomi 8 parts, Fructus Fici 20 Part, Herba Ecliptae 6 parts, the Radix Astragali 5.5 parts, 20 parts of Semen Persicae, propolis 5.5 parts.
The medicinal preparation for oral administration preparation process for the treatment of prolonged lochia is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils 30 seconds, is placed in Dry in the air at shady and cool ventilation to 45 DEG C of addition Semen Persicaes, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 3% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container.Separate The sack that Shi Caiyong nylon wire makes, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, press slag by hand, quiet Putting 5 days, filter precipitate with filter, wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 100 mesh sieves are crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 6 times, big fire is boiled, and turns slow fire boiling 22 minutes, filters, and filtrate stands and within 7 hours, takes supernatant, and filtering residue parch is crisp Crisp, grinding to form smalls, to cross 140 mesh sieves stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.4 times of mixture, by step (4) in gained filtrate is placed in transparent container, add water the mixture configured, mixed dynamic uniform, instills step after melting completely (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Test example 1: the clinical practice of medicinal preparation for oral administration of embodiment 5 gained treatment prolonged lochia: in December, 2012- In January, 2015, screen 400 example patients in 5 hospitals, sufferer is randomly divided into two groups, experimental group 200 people, matched group 200 people, Experimental group uses medicinal preparation for oral administration obtained by the present invention, and matched group uses other medicines, observes 15 days time limits, test first 1 day right The symptom of patient comprehensively checks, periodically checks inquiry patient body situation and impression, and make a record during experiment.
Using method: every time take medicinal preparation for oral administration 5-10ml of the present invention, with warm water delivery service after heating, twice on the one, within 7 days, be One course for the treatment of.
Efficacy determination: effectively: malaise symptoms alleviates or partial disappearance.Cure: malaise symptoms disappears, and without recurrence.Invalid: Malaise symptoms is unchanged or recurs.Result is as shown in the table:
Table 1: take embodiment 5 and other medicines improvement effect to treatment prolonged lochia
Group Total number of cases Cure number of cases Effectively number of cases Invalid number of cases Total effective rate
Experimental group 200 190 8 2 99%
Matched group 200 100 60 40 80%
As it can be seen from table 1 improve effect: take the healing 190 example (95%) of embodiment 5 product, effective 8 examples (4%), invalid 2 Example (1%), total effective rate 99%.Can be seen that taking the effect of embodiment 5 product is substantially better than and takes other products.
Clinical tests prove that, use medicinal preparation for oral administration of the present invention compared with the medicine of other treatment prolonged lochia, Improvement means are more fully thorough, have no side effect during use, while treatment prolonged lochia, can alleviate by lochia The symptoms such as the stomachache brought not to the utmost, abnormal flavour.Clinical tests prove that, Chinese drugs agentia effective percentage of the present invention is 99%.
Finally it should be noted that embodiment is the optimum detailed description of the invention of the present invention, be not limited to this Invention, although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it depends on So the technical scheme described in foregoing embodiments can be modified, or wherein portion of techniques feature is carried out equivalent replace Change.All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention Protection domain within.

Claims (10)

1. treat the medicinal preparation for oral administration of prolonged lochia, it is characterised in that: take off and state the primary raw material of weight proportion and be prepared from: Stigma Croci 10-20 part, Fructus Mori 3-5 part, Radix Cyathulae 5-10 part, Radix Ginseng 4-8 part, fish head 5-15 part, Ramulus Cinnamomi 6-10 part, Fructus Fici 15-25 part, Herba Ecliptae 3-8 part, Radix Astragali 4-7 part, Semen Persicae 15-25 part, propolis 3-8 part.
The medicinal preparation for oral administration for the treatment of prolonged lochia the most according to claim 1, it is characterised in that: take off and state weight proportion Primary raw material be prepared from: Stigma Croci 13-18 part, Fructus Mori 3.5-4.5 part, Radix Cyathulae 6-9 part, Radix Ginseng 5-7 part, fish head 8- 13 parts, Ramulus Cinnamomi 7-9 part, Fructus Fici 18-23 part, Herba Ecliptae 4-7 part, Radix Astragali 5-6 part, Semen Persicae 18-23 part, propolis 4-7 part.
The medicinal preparation for oral administration for the treatment of prolonged lochia the most according to claim 1, it is characterised in that: take off and state weight proportion Primary raw material be prepared from: Stigma Croci 15 parts, Fructus Mori 4 parts, Radix Cyathulae 7.5 parts, Radix Ginseng 6 parts, fish head 10 parts, Ramulus Cinnamomi 8 parts, Fructus Fici 20 parts, Herba Ecliptae 6 parts, the Radix Astragali 5.5 parts, 20 parts of Semen Persicae, propolis 5.5 parts.
4. according to the preparation method of the medicinal preparation for oral administration treating prolonged lochia described in any one of claim 1-3, its feature It is: step is as follows:
(1) being placed in by propolis in the hot pot dryouied, add water, little fire is endured slowly and is melted completely to propolis, turns big fire and boils the 20-40 second, It is placed at shady and cool ventilation and dries in the air to 40-50 DEG C of addition Semen Persicae, stir with small wooden, place in plate, dry, grind stand-by；
(2) with hands, Fructus Mori is crumbed, be placed in glass drying oven addition white sugar and potassium sulfite, be stirring evenly and then adding into cultivation prosperous The yeast mixture 3%-5% contained, stands shading fermentation, after forming fairly obvious lamination, can separate in treating container,
The sack using nylon wire to make during separation, together pours into wine liquid and distiller grains in sack, bag mouth is tightened, by hand Pressure slag, stands 3-7 days, filters precipitate with filter, and wine liquid is directly bottled stand-by；
(3) being cleaned by fresh fish head, drain away the water, be cut into small pieces, be placed in boiling hot deep fat, frying is crisp, grinds to form thin It is stand-by that 80-120 mesh sieve is crossed at end；
(4) Stigma Croci, Radix Cyathulae, Radix Ginseng, Ramulus Cinnamomi, Fructus Fici, Herba Ecliptae and the Radix Astragali are placed in marmite, add raw material gross weight The light salt brine of 4-8 times, big fire is boiled, and turns slow fire boiling 18-26 minute, filters, and filtrate stands and within 6-8 hour, takes supernatant, filtering residue Parch is crisp, and grinding to form smalls, to cross 120-160 mesh sieve stand-by；
(5) step (1), (3) gains and step (4) gained smalls are mixed, add the dextrin of 0.2-0.6 times of mixture, will Step (4) gained filtrate is placed in transparent container, and add water the mixture configured, mixed dynamic uniform, instills after melting completely Step (2) gained morat, seals and places 3 days, and taking supernatant is gained medicinal preparation for oral administration of the present invention.
Preparation method the most according to claim 4, it is characterised in that: step (1) turns big fire and boils the 25-35 second, is placed in the moon Dry in the air and add Semen Persicae to 43-48 DEG C and (preferably, turn big fire and boil 30 seconds, be placed at shady and cool ventilation and dry in the air to 45 DEG C of additions in cool ventilation Semen Persicae).
Preparation method the most according to claim 4, it is characterised in that: step (2) presses slag by hand, stands 4-6 days (preferably , press slag by hand, stand 5 days).
Preparation method the most according to claim 4, it is characterised in that: step (3) grinds to form smalls and crosses 90-110 mesh sieve and treat With (preferably, grind to form smalls cross 100 mesh sieves stand-by).
Preparation method the most according to claim 4, it is characterised in that: step (4) adds the light salt of raw material gross weight 5-7 times Water (preferably, adds the light salt brine of raw material gross weight 6 times).
Preparation method the most according to claim 4, it is characterised in that: step (4) big fire is boiled, and turns slow fire boiling 20-24 Minute, filter, filtrate stand within 6.5-7.5 hour, take supernatant (preferably, big fire is boiled, and turns slow fire boiling 22 minutes, filters, Filtrate stands and takes supernatant in 7 hours).
Preparation method the most according to claim 4, it is characterised in that: step (5) adds the paste of 0.3-0.5 times of mixture Essence (preferably, adds the dextrin of 0.4 times of mixture).
CN201610464298.0A 2016-06-24 2016-06-24 A kind of medicinal preparation for oral administration treating prolonged lochia and preparation method thereof Pending CN106074896A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579633A (en) * 2012-03-06 2012-07-18 蒋月芳 Traditional Chinese medicine composition for curing vital energy deficiency type postpartum lochiorrhea and preparation method thereof
CN104758547A (en) * 2015-03-19 2015-07-08 黄淑娟 Traditional Chinese medicinal composition for treating prolonged lochia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579633A (en) * 2012-03-06 2012-07-18 蒋月芳 Traditional Chinese medicine composition for curing vital energy deficiency type postpartum lochiorrhea and preparation method thereof
CN104758547A (en) * 2015-03-19 2015-07-08 黄淑娟 Traditional Chinese medicinal composition for treating prolonged lochia

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Application publication date: 20161109