CN106074839B - 一种提高动物繁育性能的兽药组合物及其制备方法 - Google Patents
一种提高动物繁育性能的兽药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种提高动物繁育性能的兽药组合物，它是由下述重量配比的原料药制备而成的制剂：淫羊藿100～150份、杜仲60～150份、党参50～100份、白术60～120份、熟地黄50～150份、当归50～150份。该组合物在动物发情配种与怀孕前期使用，结果表明可显著提高产仔数量，增加断奶幼仔重量，减少母畜产后炎症，缩短发情间隔，具有良好的提高动物繁育性能的药效。
Description
技术领域
本发明涉及一种提高动物繁育性能的兽药组合物及其制备方法，属于医药领域。
背景技术
动物繁育性能下降是由于疾病因素、营养因素、环境因素等多种不良因素长期刺激动物机体，导致其体内毒素、毒物大量蓄积，正常的新陈代谢与生殖代谢受损或紊乱，机体健康水平下降，从而出现各类生殖系统病症，如流产、早产、难产、弱仔、子宫内膜炎、阴道炎、发情紊乱等，同时还会对初生幼仔的生长发育产生不良影响。目前，动物繁育性能低下已严重影响畜牧业的发展，也是畜牧业经营中亏损的重要原因。
由于导致动物繁育性能下降的原因多样，表现复杂，多种症状往往同时或交替出现，现有的一些治疗方法大多存在疗效不佳或操作不方便等缺陷。比如，母畜产后易受到细菌感染，从而引发子宫内膜炎，导致母畜不孕不育；目前的治疗方法一般是采用高锰酸钾溶液、新洁尔灭溶液冲洗子宫，或子宫灌注抗生素及消毒药液，同时应用子宫收缩剂，增强子宫收缩力，促进渗出物的排出。上述治疗方法虽然能在一定程度上缓解炎性症状，但病情容易复发，且治疗过程中往往给母畜带来较大痛苦。
相较而言，中兽医学对动物繁育性能低下进行了长期、深入的研究，认为其主要病因是由于疫毒内侵、正气受损致机体脾肾双虚、精气不足、冲任脉虚、气滞血瘀，故表现发情、胎产异常及全身损害。与西医相比，中兽药在提高动物繁育性能方面具有药效良好、毒副作用小等明显优势。
因此，提供一种提高动物繁育性能效果较好的中兽药组合物，成为了一个亟待解决的问题。
发明内容
本发明的目的在于提供一种提高动物繁育性能的兽药组合物及其制备方法。
本发明提供了一种提高动物繁育性能的兽药组合物，它是由下述重量配比的原料药制备而成的制剂：淫羊藿100～150份、杜仲60～150份、党参50～100份、白术60～120份、熟地黄50～150份、当归50～150份。
优选的，它是由下述重量配比的原料药制备而成的制剂：淫羊藿150份、杜仲150份、党参100份、白术120份、熟地黄150份、当归150份。
进一步的，它是由各重量配比原料药的原生药粉、水或有机溶剂提取物，加入药学上可接受的辅料或者辅助性成分制备而成的制剂。
进一步的，所述的制剂为口服制剂。
进一步的，所述的制剂为散剂、颗粒剂、丸剂、片剂、胶囊剂或合剂。
本发明提供了一种所述兽药组合物的制备方法，包括如下步骤：取各重量配比的原料药，直接打粉，或加入水或有机溶剂提取，再加入药学上可接受的辅料或者辅助性成分，即得。
进一步的，包括如下步骤：取各重量配比的原料药，加入20～30倍体积量的水，煎煮2次，每次2小时，收集水煎液，浓缩，干燥，即得。
本发明提供了所述兽药组合物在制备提高动物繁育性能的药物中的用途。
优选的，所述的药物是提高母猪繁育性能的药物。
进一步的，所述的药物具有提高产仔数量、增加断奶幼仔重量、减少母畜产后炎症或缩短发情间隔的功效。
本发明提供了一种提高动物繁育性能的兽药组合物。该组合物根据中兽医学理论，确立基本治则为脾肾双补、滋阴生精，调经活血、祛瘀化滞。以此治则为指导，采用中药淫羊藿、杜仲、党参、白术、熟地黄、当归组方，方中淫羊藿、杜仲补肾阳、强筋骨，共作为君药；党参、白术补气益脾，作为臣药；熟地黄、当归补血滋阴、补血养血、活血化滞，共为佐使药，诸药合用，共奏补肾补脾、补气生血、滋阴生精之功效。本发明组合物在动物发情配种与怀孕前期使用，结果表明可显著提高产仔数量，增加断奶幼仔重量，减少母畜产后炎症，缩短发情间隔，具有良好的提高动物繁育性能的药效。
显然，根据本发明的上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
具体实施方式
本发明具体实施方式中使用的原料、设备均为已知产品，通过购买市售产品获得。
实施例1本发明散剂的制备方法
取淫羊藿10kg、杜仲6kg、党参5kg、白术6kg、熟地黄5kg、当归5kg，粉碎，60-80目过筛，分装，即得本发明药物A。
实施例2本发明兽药水提物的制备方法
取淫羊藿10kg、杜仲6kg、党参5kg、白术6kg、熟地黄5kg、当归5kg，加20-30倍体积纯净水，煎煮2次，每次2小时，减压浓缩后喷雾干燥，即得本发明提取物B。
实施例3本发明散剂的制备方法
取淫羊藿15kg、杜仲15kg、党参10kg、白术12kg、熟地黄15kg、当归15kg，粉碎，60-80目过筛，分装，即得本发明药物C。
实施例4本发明兽药水提物的制备方法
取淫羊藿15kg、杜仲15kg、党参10kg、白术12kg、熟地黄15kg、当归15kg，加20-30倍体积纯净水，煎煮2次，每次2小时，减压浓缩后喷雾干燥，即得本发明提取物D。
以下通过药效实验证明本发明的有益效果。
实验例1本发明组合物提高母猪繁育性能的效果研究
1、实验药物
根据实施例1～4制备的本发明药物A～D。
2、实验方法
随机选择180头母猪，平均分为5个组，每组36头，实验A和C组分别在配种前7天在日常饲料中按每吨饲料添加药物A和药物C 3kg，实验B和D组分别在配种前7天在日常饲料中按每吨饲料添加提取物B和提取物D0.6kg(对应原生药材用量3kg)，各实验组均连续添加30天；对照组为正常饲料，不添加任何药物。观察各组母猪繁育情况，结果见表1。
表1本发明组合物对母猪繁育性能影响实验结果
| 考察指标 | 实验组A | 实验组B | 实验组C | 实验组D | 对照组 |
| 母猪数(头) | 36 | 36 | 36 | 36 | 36 |
| 产仔总数(头) | 408 | 412 | 413 | 417 | 396 |
| 断奶仔猪总重量(公斤) | 305.4 | 307.2 | 308.9 | 311.7 | 291.1 |
| 断奶仔猪平均重(公斤) | 8.53 | 8.62 | 8.69 | 8.74 | 7.92 |
| 母猪有明显炎症(头) | 3 | 2 | 0 | 0 | 8 |
| 平均断奶发情间隔(天) | 5.8 | 5.9 | 5.8 | 5.6 | 7.1 |
实验结果：与对照组相比，给予本发明药物的实验组A～D母猪产仔总数均显著增加，分别多产12、16、17和21头仔猪，且断奶仔猪总重量分别高于对照组14.3kg、16.1kg、17.8和20.6kg，断奶仔猪平均重分别高于对照组0.61kg、0.7kg、0.77kg和0.82kg，表明本发明药物具有促进初生幼仔生长发育的作用。另外，母猪产后子宫内膜炎、乳房炎情况明显减少，平均断奶发情间隔缩短1.2天以上。
以上结果表明，本发明组合物具有良好的提高动物繁育性能的药效；其中，综合表1所列各项反映动物繁育性能的指标，本发明药物D的效果最佳。
Claims (8)
1.一种提高母猪繁育性能的兽药组合物，其特征是：它是由下述重量配比的原料药制备而成的制剂：淫羊藿150份、杜仲150份、党参100份、白术120份、熟地黄150份、当归150份。
2.如权利要求1所述的兽药组合物，其特征是：它是由各重量配比原料药的药粉、或水提取物、或有机溶剂提取物，加入药学上可接受的辅料制备而成的制剂。
3.如权利要求2所述的兽药组合物，其特征是：所述的制剂为口服制剂。
4.如权利要求3所述的兽药组合物，其特征是：所述的制剂为散剂、颗粒剂、丸剂、片剂、胶囊剂或合剂。
5.一种权利要求1~4任意一项所述兽药组合物的制备方法，其特征是：包括如下步骤：取各重量配比的原料药，直接打粉、或加入水或有机溶剂提取，再加入药学上可接受的辅料，即得。
6.如权利要求5所述的制备方法，其特征是：加入水提取的步骤包括：取各重量配比的原料药，加入20~30倍体积量的水，煎煮2次，每次2小时，收集水煎液，浓缩，干燥，即得。
7.权利要求1~4任意一项所述兽药组合物在制备提高母猪繁育性能的药物中的用途。
8.如权利要求7所述的用途，其特征是：所述的药物具有提高产仔数量、增加断奶幼仔重量、减少母畜产后炎症或缩短发情间隔的功效。
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