CN106063904A - 一种治疗肥胖的口服液的制备方法 - Google Patents

一种治疗肥胖的口服液的制备方法 Download PDF

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CN106063904A
CN106063904A CN201610389492.7A CN201610389492A CN106063904A CN 106063904 A CN106063904 A CN 106063904A CN 201610389492 A CN201610389492 A CN 201610389492A CN 106063904 A CN106063904 A CN 106063904A
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李艳梅
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Abstract

本发明公开了一种治疗肥胖的口服液的制备方法，将中药组合物干燥粉碎，得到原料粉，所述中药组合物包括以下重量份的原料：茯苓13‑18、猪苓8‑12、冬瓜皮8‑12、薏米仁10‑15、通草8‑12、焦白术18‑22、太子参8‑12、山药13‑18、焦山楂18‑22、炒麦芽18‑22、焦神曲13‑18、鸡内金8‑12、川厚朴4‑6以及白豆蔻5‑8；将原料粉与乙醇混合浸提，浸提结束后加热使乙醇蒸发，得到浸提物；将浸提物稀释，即得所述治疗肥胖的口服液。

Description

一种治疗肥胖的口服液的制备方法
技术领域
本发明涉及中医药领域，尤其涉及一种治疗肥胖的口服液的制备方法。
背景技术
肥胖症是一种由多种因素引起的慢性代谢性疾病，以体内脂肪细胞的体积和细胞数增加致体脂占体重的百分比异常增高并在某些局部过多沉积脂肪为特点。单纯性肥胖患者全身脂肪分布比较均匀，没有内分泌紊乱现象，也无代谢障碍性疾病，其家族往往有肥胖病史。
目前临床用体重指数(BMI)来评价：<18.5kg·m-2者为体重过低，18.5～23.9kg·m-2为正常范围，≥24kg·m-2为超重；≥28kg·m-2为肥胖。
现有的减肥方法多种多样，有运动、饮食控制、按摩、药物、针灸减肥等，效果不一，而且有的减肥产品副作用较大。
发明内容
本发明的一个目的是解决至少上述问题和/或缺陷，并提供至少后面将说明的优点。
本发明的另一个目的是提供一种治疗肥胖的口服液的制备方法，能够得到有效治疗肥胖的口服液。
为实现上述目的和一些其他的目的，本发明采用如下技术方案
一种治疗肥胖的口服液的制备方法，包括以下步骤：
步骤1、浸提，将中药组合物干燥粉碎，得到原料粉，所述中药组合物包括以下重量份的原料：茯苓13-18、猪苓8-12、冬瓜皮8-12、薏米仁10-15、通草8-12、焦白术18-22、太子参8-12、山药13-18、焦山楂18-22、炒麦芽18-22、焦神曲13-18、鸡内金8-12、川厚朴4-6以及白豆蔻5-8；
步骤2、将原料粉与10-30倍体积的60-70％乙醇溶液混合浸提，浸提结束后加热使乙醇蒸发，得到浸提物；
步骤3、将浸提物加蒸馏水稀释5-8倍，即得所述治疗肥胖的口服液。
优选的是，所述的治疗肥胖的口服液的制备方法中，步骤3中向治疗肥胖的口服液中添加5-8％的麦芽糖醇。
优选的是，所述的治疗肥胖的口服液的制备方法中，步骤2中浸提方法为分步浸提法，具体方法为：
步骤2.1、第一次浸提，浸提温度为30-50℃，浸提时间30-40分钟，过滤得到第一浸提液；
步骤2.2、第二次浸提，将第一次浸提过滤的截留物与乙醇混合进行第二次浸提，浸提温度为60-80℃，浸提时间20-30分钟，过滤得到第二浸提液；
步骤2.3、将第一浸提液与第二浸提液混合，加热至80-85℃使乙醇蒸发，即得所述浸提物。
本发明至少包括以下有益效果：首先，本发明利用中医五行及辨证理论，认为肥胖多因湿热壅滞中焦，结於膈膜之中，久则脾气虚损，阻凝运化，油膜不利，决渎不行，遂益形胖大。本发明通过多种中药科学配伍，利湿热、健脾气、消壅滞，达到有效减肥的目的。
其次，通过将可有效治疗肥胖的中药组合物进行分步乙醇浸提，使所制备的治疗肥胖的口服液不仅服用方便，而且有利于药物有效成分的吸收，有效治疗肥胖。
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面对本发明做详细说明，以令本领域普通技术人员参阅本说明书后能够据以实施。
一种治疗肥胖的口服液的制备方法，包括以下步骤：
步骤1、浸提，将中药组合物干燥粉碎，得到原料粉，所述中药组合物包括以下重量份的原料：茯苓13-18、猪苓8-12、冬瓜皮8-12、薏米仁10-15、通草8-12、焦白术18-22、太子参8-12、山药13-18、焦山楂18-22、炒麦芽18-22、焦神曲13-18、鸡内金8-12、川厚朴4-6以及白豆蔻5-8；
步骤2、将原料粉与10-30倍体积的60-70％乙醇溶液混合浸提，浸提结束后加热使乙醇蒸发，得到浸提物；
步骤3、将浸提物加蒸馏水稀释5-8倍，即得所述治疗肥胖的口服液。
本发明利用中医五行及辨证理论，认为肥胖多因湿热壅滞中焦，结於膈膜之中，久则脾气虚损，阻凝运化，油膜不利，决渎不行，遂益形胖大。
本发明的具体药理为：
茯苓，利水渗湿、健脾；
猪苓，解热除湿、行窍利水；
冬瓜皮，利尿除湿；
薏米仁，健脾、利尿、清湿热；
通草，清热、利尿；
焦白术，燥湿、健脾气；
太子参，益气健脾；
山药，益肾气、健脾胃；
焦山楂，消食导滞；
炒麦芽，行气消食、健脾开胃；
焦神曲，消壅滞、健脾和胃；
鸡内金，宽中健脾、消壅滞；
砂仁，芳香化湿、健脾气；
川厚朴，燥湿、下气除满；
白豆蔻，化湿行气、消壅滞。
本发明通过以上多种中药科学配伍，利湿热、健脾气、消壅滞，达到有效减肥的目的。
通过将可有效治疗肥胖的中药组合物进行分步乙醇浸提，使所制备的治疗肥胖的口服液不仅服用方便，而且有利于药物有效成分的吸收，有效治疗肥胖。
所述的治疗肥胖的口服液的制备方法中，步骤3中向治疗肥胖的口服液中添加5-8％的麦芽糖醇。
所述的治疗肥胖的口服液的制备方法中，步骤2中浸提方法为分步浸提 法，具体方法为：
步骤2.1、第一次浸提，浸提温度为30-50℃，浸提时间30-40分钟，过滤得到第一浸提液；
步骤2.2、第二次浸提，将第一次浸提过滤的截留物与乙醇混合进行第二次浸提，浸提温度为60-80℃，浸提时间20-30分钟，过滤得到第二浸提液；
步骤2.3、将第一浸提液与第二浸提液混合，加热至80-85℃使乙醇蒸发，即得所述浸提物。
分步浸提能够使药物有效成分更加充分释放，提高药物疗效。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (3)

1.一种治疗肥胖的口服液的制备方法，其特征在于，包括以下步骤：
步骤1、浸提，将中药组合物干燥粉碎，得到原料粉，所述中药组合物包括以下重量份的原料：茯苓13-18、猪苓8-12、冬瓜皮8-12、薏米仁10-15、通草8-12、焦白术18-22、太子参8-12、山药13-18、焦山楂18-22、炒麦芽18-22、焦神曲13-18、鸡内金8-12、川厚朴4-6以及白豆蔻5-8；
步骤2、将原料粉与10-30倍体积的60-70％乙醇溶液混合浸提，浸提结束后加热使乙醇蒸发，得到浸提物；
步骤3、将浸提物加蒸馏水稀释5-8倍，即得所述治疗肥胖的口服液。
2.如权利要求1所述的治疗肥胖的口服液的制备方法，其特征在于，步骤3中向治疗肥胖的口服液中添加5-8％的麦芽糖醇。
3.如权利要求1所述的治疗肥胖的口服液的制备方法，其特征在于，步骤2中浸提方法为分步浸提法，具体方法为：
步骤2.1、第一次浸提，浸提温度为30-50℃，浸提时间30-40分钟，过滤得到第一浸提液；
步骤2.2、第二次浸提，将第一次浸提过滤的截留物与乙醇混合进行第二次浸提，浸提温度为60-80℃，浸提时间20-30分钟，过滤得到第二浸提液；
步骤2.3、将第一浸提液与第二浸提液混合，加热至80-85℃使乙醇蒸发，即得所述浸提物。
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