CN104306943A - 一种治疗高血脂症的中药组合物 - Google Patents

一种治疗高血脂症的中药组合物 Download PDF

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CN104306943A
CN104306943A CN201410605904.7A CN201410605904A CN104306943A CN 104306943 A CN104306943 A CN 104306943A CN 201410605904 A CN201410605904 A CN 201410605904A CN 104306943 A CN104306943 A CN 104306943A
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吴翠霞
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Abstract

本发明公开了一种治疗高血脂症的中药组合物,属于中药技术领域,由下述原料制备而成:半夏5-15克,陈皮5-15克,女贞子5-15克,枸杞子5-15克,虎杖5-15克,牛膝5-15克,姜黄5-15克,三七5-15克,川芎10-20克,红花10-20克,柴胡10-20克,丹参10-20克,车前子10-20克,何首乌10-20克,党参10-20克,桂枝10-20克,防己10-20克,当归10-20克,山楂10-20克,丹参15-25克,生姜5-15克,大枣2-5枚。本发明将以上药物组合后,药效具有协同作用,起到补肾温阳、健脾益气、活血化瘀、清利湿热的作用,使血液黏稠度下降,达到标本兼治的目的。

Description

一种治疗高血脂症的中药组合物
技术领域
[0001] 本发明涉及一种治疗高血脂症的中药组合物,属于中药技术领域。
背景技术
[0002] 血脂指的是人体血浆中的游离脂肪酸、磷脂、固醇和甘油三脂等脂肪素的含量。血浆中血脂的含量大于160mg/dl的医学上称之为血液脂肪素超标,即为高血脂。随着经济的发展,人们生活水平不断提高,过度营养和高脂肪食物摄取,造成部分人群出现高血脂症。权威健康机构统计数据显示,我国心脑肾血管疾病的发病率、病死率正在逐年上升,它不仅成为我国中老年人死亡的首位原因,而且有逐渐年轻化的趋势。患上高血脂症的原因主要包括遗传因素、饮食因素以及血液中缺乏负离子(负氧离子),或由于其他中间原发疾病所引起,如糖尿病、肝病、甲状腺疾病、肾脏疾病、胰腺、肥胖症等。高血脂患者在临床表现出各种症状,头晕、胸闷、神疲乏力等。因为症状多且广,因此很容易混淆成别的疾病。
[0003]目前临床观察有效降血脂的办法就是使用西医的降脂药,但是降脂药一旦停药,如果饮食控制和有氧运动不能跟上的话,血脂还会反弹。而且降脂药的毒副作用也是非常大的,长期服用对身体伤害较大。
发明内容
[0004] 本发明公开了一种治疗高血脂症的中药组合物,该药物均采用纯天然中草药,无毒副作用,能对患者肿瘤手术后有明显巩固作用,该制备方法简单方便,可以达到较好的效果O
[0005] 本发明解决技术问题所采取的技术方案是:
[0006] 一种治疗高血脂症的中药组合物,其特征是,由以下重量份的中药制成:
[0007] 半夏5 — 15克,陈皮5 — 15克,女贞子5 — 15克,枸杞子5 — 15克,虎杖5 — 15克,牛膝5 — 15克,姜黄5 — 15克,三七5— 15克,川弯10 — 20克,红花10 —20克,柴胡10 — 20克,丹参10 — 20克,车前子10 - 20克,何首乌10 — 20克,党参10 — 20克,桂枝10 — 20克,防己10 — 20克,当归10 — 20克,山楂10 — 20克,丹参15 — 25克,生姜5 — 15克,大枣2 — 5枚。
[0008] 优选的,由以下重量份的中药制成:
[0009] 半夏10克,陈皮10克,女贞子10克,枸杞子10克,虎杖10克,牛膝10克,姜黄10克,三七10克,川芎15克,红花15克,柴胡15克,丹参15克,车前子15克,何首乌15克,党参15克,桂枝15克,防己15克,当归15克,山楂15克,丹参20克,生姜10克,大枣3枚。
[0010] 制备方法:
[0011] ①根据上述的重量称取原料,
[0012] ②将步骤①中称取的内服药物原料置于砂锅中,然后加水至没过原料2-5cm,浸泡10-20min后,加热至50°C,加盖保温20_50min ;然后大火加热至沸腾,转小火煎煮30-90min,过滤,得滤液一,滤渣留于锅中,加水至没过滤渣,继续煎煮10_20min,过滤,得滤液二 ;
[0013] ③将滤液一和滤液二合并,混合,即得内服药物;
[0014] 服用方法:每日一剂,每剂两次。
[0015] 各中药的药理作用:
[0016] 半夏:燥湿经痰,降逆止呕,消痞散结。治湿痰冷饮,呕吐反胃,痰厥头痛,头晕不眠。
[0017] 陈皮:性温,味苦、辛。理气健脾,燥湿化痰。用于胸脘胀满、食少吐泻、咳嗽多痰。
[0018] 女贞子:甘、苦,凉。归肝、肾经。功能主治:滋补肝肾,明目乌发。用于眩晕耳鸣,腰膝酸软,须发早白,目暗不明。
[0019] 枸杞子:甘,平。入肝、肾经。滋肾,润肺,补肝,明目。治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。
[0020] 虎杖:苦,寒,归肝、肺、胆经。清热解毒,活血止痛,利湿退黄,止咳平喘。本品苦寒降泄,功擅清利肝胆湿热,又能活血通经止痛。牛膝
[0021] 姜黄:破血,行气,通经,止痛。治心腹痞满胀痛,臂痛,癥瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。
[0022] 三七:甘微苦,温。入肝、胃、大肠经。止血,散瘀,消肿,定痛。治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。
[0023] 川芎:味辛,温。入肝、胆经。行气开郁,祛风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
[0024] 红花:辛,温。入心、肝经。活血通经,去瘀止痛,瘀血作痛。有扩张冠状动脉、降低血压以及降低血清总胆固醇和甘油三脂的作用。
[0025] 柴胡:辛、微苦、微寒;归肝、胆经。解表退热,舒肝解郁,升举阳气。本品疏达善透,长于疏解肝胆郁热,又能疏肝理气,为治疗肝胆郁热、肝郁气滞所致胁肋疼痛要药。药理研究证实:柴胡有较强的解热、抗炎、抗菌、抗病毒、保肝、利胆、镇静、镇痛等作用。
[0026] 丹参:苦,微寒;归心、肝经。活血化淤,凉血宁心。本品降而行血,善入血分,能通经脉、化淤滞、清心火、凉血热,安神志、除悸烦,常用于胸痹心痛,月经部调、疮疡肿痛,失眠及淤血肿痛等症。
[0027] 车前子:利水,清热,明目,祛痰。治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。
[0028] 何首乌:苦甘涩,微温。入肝、肾经。补肝,益肾,养血,祛风。治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,能促进肠道蠕动,减少胆固醇吸收,加快胆固醇排泄,从而起到降低血脂,抗动脉粥样硬化的作用,用于眩晕耳鸣、须发早白、腰膝酸软、肢体麻木、神经衰弱、高血脂症。党参:甘,平。归脾、肺经。功能主治:补中益气,健脾益肺。用于脾肺虚弱,气短心悸,食少便溏,虚喘咳嗽,内热消渴。
[0029] 桂枝:辛甘,温。入膀胱、心、肺经。发汗解肌,温经通脉。治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。
[0030] 防己:苦,寒。归膀胱、肺经。利水消肿,祛风止痛。用于水肿脚气,小便不利,湿疹疮毒,风湿痹痛;高血压。
[0031] 当归:甘辛,温。入心、肝、脾经。补血和血,调经止痛,润燥滑肠。治月经不调,经闭腹痛,癥瘕结聚,崩漏;血虚头痛,眩晕,痿痹;肠燥便难,赤痢后重;痈疽疮窃,跌扑损伤。
[0032] 山楂:酸甘,微温。入脾、胃、肝经。消食积,散瘀血,驱绦虫。治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气产后儿枕痛,恶露不尽,小儿乳食停滞。
[0033] 丹参:苦,微寒;归心、肝经。活血化淤,凉血宁心。本品降而行血,善入血分,能通经脉、化淤滞、清心火、凉血热,安神志、除悸烦,常用于胸痹心痛,月经部调、疮疡肿痛,失眠及淤血肿痛等症。
[0034] 生姜、大枣:作为引经药或佐使药,生姜和大枣在方剂中具有配合方剂中的君、臣药加强治疗作用,或直接治疗次要症状;用以消除或减弱君、臣药的毒性或制约君、臣药的峻烈之性;在病重邪甚,可能拒药时,又能在方剂中起相成作用;能引方剂中诸药至病所;具有调和方剂中诸药的作用。
[0035] 祖国医学认为高脂血症的发生与肝脾肾关系密切。饮食不节、肥甘厚腻、过逸少劳、情志不畅是造成本病的外因;肝失疏泄、脾失健运、肾精亏虚、肾阳衰弱,三脏功能失衡、导致血脂代谢异常是本病的内因,内外因造成本虚标实恶性循环损及肝、脾、肾三脏。
[0036] 本发明的有益效果是:本发明将以上药物组合后,药效具有协同作用,起到补肾温阳、健脾益气、活血化瘀、清利湿热的作用,使血液黏稠度下降,达到标本兼治的目的。
[0037] 以下结合临床资料及典型病例对本发明的有益效果进一步说明。
[0038] 一、临床观察
[0039] 选取2013年I月至2014年8月某院心血管内科门诊诊断的高脂血症患者80例。其中男38例、女42例,平均年龄(55±2)岁,病程0.5〜32年。80例高脂血症患者中合并冠心病21例、高血压42例、糖尿病14例、慢性肾功能不全9例、脑梗死8例。
[0040] 2、诊断标准:一般以成年人空腹血清总胆固醇超过572毫摩尔/升,甘油三酯超过1.70毫摩尔/升,诊断为高脂血症。将总胆固醇在5.2〜5.7毫摩尔/升者称为边缘性升闻。
[0041] 3、治疗方法:服用本发明药物,水煎煮,分两次早晚服用。15天为I个疗程。
[0042] 4、疗效标准:
[0043] 显效:经治疗后,临床症状基本消失,血清胆固醇及甘油三酯恢复正常或其下降值
> 40mg% ο
[0044] 有效:经治疗后,临床症状有所改善,血清胆固醇、甘油三酯下降值> 20mg%。
[0045] 无效:治疗后,临床症状略有改善或无改善,血清胆固醇、甘油三酯下降值在20mg%以下。
[0046] 5、治疗结果:显效68例;有效9例;无效3例。有效率为96.3% ;
[0047] 结论:本发明的配方成分简单,成本低廉,治疗高血脂症具有见效快、不反复等优点。
[0048] 2、典型病例:
[0049] 例1:张某某,女,62岁。患者身高163cm,体重88kg。I年前感觉憋气、胸闷、头晕、头痛、气短,去医院诊断为高脂血症。服用本发明药物治疗,服药I个疗程后,临床症状有所改善,去医院检查血清胆固醇及甘油三酯基本恢复正常,继续巩固治疗I个疗程,所有症状消失,血脂正常。随访半年未见复发。
[0050] 例2:战某某,男,60岁。患有高血脂症3年,患者自觉经常觉头痛,眩晕耳鸣,经常体倦、乏力,腰膝酸软,手足怕冷,症状严重时,即服用西药治疗一段时间,停药后不久,血脂就会再次升高,半年前,患者开始服用本发明药物治疗,服药I个疗程后,头晕头痛、体倦、乏力等症状有很大改善,继续巩固治疗I个疗程,所有症状消失,血脂正常。
具体实施方式
[0051] 实施例1
[0052] 一种治疗高血脂症的中药组合物,由以下重量份的中药制成:
[0053] 半夏10克,陈皮10克,女贞子10克,枸杞子10克,虎杖10克,牛膝10克,姜黄10克,三七10克,川芎15克,红花15克,柴胡15克,丹参15克,车前子15克,何首乌15克,党参15克,桂枝15克,防己15克,当归15克,山楂15克,丹参20克,生姜10克,大枣3枚。
[0054] 制备方法:
[0055] ①根据上述的重量称取原料,
[0056] ②将步骤①中称取的内服药物原料置于砂锅中,然后加水至没过原料2-5cm,浸泡10-20min后,加热至50°C,加盖保温20_50min ;然后大火加热至沸腾,转小火煎煮30-90min,过滤,得滤液一,滤渣留于锅中,加水至没过滤渣,继续煎煮10_20min,过滤,得滤液二 ;
[0057] ③将滤液一和滤液二合并,混合,即得内服药物;
[0058] 服用方法:每日一剂,每剂两次。
[0059] 实施例2
[0060] 一种治疗高血脂症的中药组合物,由以下重量份的中药制成:
[0061] 半夏10克,陈皮10克,女贞子10克,枸杞子10克,虎杖12克,牛膝12克,姜黄12克,三七12克,川芎15克,红花15克,柴胡15克,丹参15克,车前子15克,何首乌15克,党参15克,桂枝15克,防己20克,当归20克,山楂20克,丹参20克,生姜10克,大枣3枚。
[0062] 制备方法及服用方法:同例I。
[0063] 实施例3
[0064] 一种治疗高血脂症的中药组合物,由以下重量份的中药制成:
[0065] 半夏10克,陈皮10克,女贞子10克,枸杞子10克,虎杖10克,牛膝10克,姜黄10克,三七15克,川芎15克,红花15克,柴胡15克,丹参15克,车前子15克,何首乌20克,党参15克,桂枝15克,防己15克,当归15克,山楂20克,丹参20克,生姜8克,大枣5枚。
[0066] 制备方法及服用方法:同例I。

Claims (2)

1.一种治疗高血脂症的中药组合物,其特征是,由以下重量份的中药制成: 半夏5 — 15克,陈皮5— 15克,女贞子5 — 15克,枸杞子5— 15克,虎杖5 — 15克,牛膝5 — 15克,姜黄5 — 15克,三七5 — 15克,川芎10 — 20克,红花10 — 20克,柴胡10 — 20克,丹参10 — 20克,车前子10 — 20克,何首乌10 — 20克,党参10 — 20克,桂枝10 — 20克,防己10 — 20克,当归10 - 20克,山楂10 — 20克,丹参15 — 25克,生姜5-15克,大枣2 — 5枚。
2.根据权利要求1所述的治疗高血脂症的中药组合物,其特征是,由以下重量份的中药制成: 半夏10克,陈皮10克,女贞子10克,枸杞子10克,虎杖10克,牛膝10克,姜黄10克,三七10克,川芎15克,红花15克,柴胡15克,丹参15克,车前子15克,何首乌15克,党参15克,桂枝15克,防己15克,当归15克,山楂15克,丹参20克,生姜10克,大枣3枚。
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