CN106062194A - 用于调整肌腱愈合的材料和方法 - Google Patents

用于调整肌腱愈合的材料和方法 Download PDF

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Publication number
CN106062194A
CN106062194A CN201580004551.8A CN201580004551A CN106062194A CN 106062194 A CN106062194 A CN 106062194A CN 201580004551 A CN201580004551 A CN 201580004551A CN 106062194 A CN106062194 A CN 106062194A
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mir
tendon
homogeneity
sequence
precursor
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Chinese (zh)
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D·S·吉尔克里斯特
N·L·米勒
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University of Glasgow
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University of Glasgow
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201580004551.8A 2014-01-14 2015-01-14 用于调整肌腱愈合的材料和方法 Pending CN106062194A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1400598.7 2014-01-14
GB201400598A GB201400598D0 (en) 2014-01-14 2014-01-14 Materials and methods for modulation of tendon healing
PCT/GB2015/050066 WO2015107340A1 (en) 2014-01-14 2015-01-14 Materials and methods for modulation of tendon healing

Publications (1)

Publication Number Publication Date
CN106062194A true CN106062194A (zh) 2016-10-26

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CN201580004551.8A Pending CN106062194A (zh) 2014-01-14 2015-01-14 用于调整肌腱愈合的材料和方法

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US (2) US9932582B2 (https=)
EP (1) EP3094727B1 (https=)
JP (2) JP6665107B2 (https=)
CN (1) CN106062194A (https=)
AU (1) AU2015207351C1 (https=)
CA (1) CA2935623C (https=)
DK (1) DK3094727T3 (https=)
ES (1) ES2661111T3 (https=)
GB (1) GB201400598D0 (https=)
HR (1) HRP20180377T1 (https=)
HU (1) HUE036049T2 (https=)
NO (1) NO3094727T3 (https=)
PL (1) PL3094727T3 (https=)
PT (1) PT3094727T (https=)
RS (1) RS56915B1 (https=)
RU (1) RU2699706C2 (https=)
SA (1) SA516371485B1 (https=)
SI (1) SI3094727T1 (https=)
TR (1) TR201802656T4 (https=)
WO (1) WO2015107340A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112080568A (zh) * 2020-09-27 2020-12-15 扬州大学 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201400598D0 (en) * 2014-01-14 2014-03-05 Univ Glasgow Materials and methods for modulation of tendon healing
US9376681B2 (en) * 2014-09-08 2016-06-28 MiRagen Therapeutics, Inc. miR-29 mimics and uses thereof
JP2018509912A (ja) * 2015-03-16 2018-04-12 ミラゲン セラピューティクス， インコーポレイテッド 感覚の状態を処置することにおけるｍｉＲＮＡ模倣物およびその使用
ES2977730T3 (es) 2016-04-15 2024-08-29 Res Inst Nationwide Childrens Hospital Administración de microARN-29 y micro-distrofina por virus adenoasociado para tratar la distrofia muscular
EP3596112A2 (en) 2017-03-17 2020-01-22 Newcastle University Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
MA50836A (fr) 2017-10-18 2020-08-26 Res Inst Nationwide Childrens Hospital Administration par vecteur à virus adéno-associé de micro-dystrophine spécifique de muscles pour traiter la dystrophie musculaire
MY208145A (en) 2018-06-18 2025-04-18 Res Inst Nationwide Childrens Hospital Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy
WO2021178344A1 (en) * 2020-03-04 2021-09-10 The Trustees Of Indiana University Methods to re-engage a fetal wound healing pathway for adult skin repair
US11987793B2 (en) 2020-05-03 2024-05-21 Washington University Compositions and methods for prevention of bladder fibrosis
RU2743804C1 (ru) * 2020-08-03 2021-02-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ Способ моделирования тендинопатии
GB202016863D0 (en) * 2020-10-23 2020-12-09 Causeway Therapeutics Ltd Microrna-29 compounds, compositions and uses in therapy
KR20230102595A (ko) * 2021-12-30 2023-07-07 주식회사 이노제닉스 포스파티딜이노시톨 3-키나아제 촉매 소단위 알파 유전자의 3'비번역 부위에 특이적으로 결합하는 핵산 절편 및 그 응용
AU2023445724A1 (en) 2023-04-28 2025-11-06 Causeway Therapeutics Limited Microrna-29 compounds, compositions and uses in therapy, and methods for evaluating tendinopathic lesions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2331143A2 (en) * 2008-09-04 2011-06-15 Universität Zürich Prorektorat Mnw Treatment of scleroderma
WO2013142336A1 (en) * 2012-03-21 2013-09-26 Miller Leonard B Combination therapy to improve joint, tendon, and ligament healing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007281261B2 (en) 2006-08-01 2013-03-21 Board Of Regents Of The University Of Texas System Identification of a micro-RNA that activates expression of beta-myosin heavy chain
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
EP2187896B1 (en) 2007-07-31 2016-01-13 The Board of Regents of The University of Texas System Inhibitors of mir-499 and mir-208b for use in the treatment of pathologic cardiac hypertrophy, heart failure or myocardial infarction
EP2182969B1 (en) 2007-07-31 2016-11-16 The Board of Regents of The University of Texas System A micro-rna family that modulates fibrosis and uses thereof
WO2010129672A1 (en) 2009-05-05 2010-11-11 Miragen Therapeutics Lipophilic polynucleotide conjugates
SG176716A1 (en) 2009-06-08 2012-01-30 Miragen Therapeutics CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS
WO2010148050A2 (en) 2009-06-16 2010-12-23 Curna, Inc. Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
US8846631B2 (en) 2010-01-14 2014-09-30 Regulus Therapeutics Inc. MicroRNA compositions and methods
WO2012061810A1 (en) 2010-11-05 2012-05-10 Miragen Therapeutics Base modified oligonucleotides
SG10201600836PA (en) 2011-02-03 2016-03-30 Mirna Therapeutics Inc Synthetic mimics of mir-34
JP2014506789A (ja) 2011-02-03 2014-03-20 マーナ セラピューティクス インコーポレイテッド ｍｉＲ−１２４の合成模倣体
US20140010801A1 (en) 2012-06-08 2014-01-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function
US9267139B2 (en) 2012-10-11 2016-02-23 Georgia Regents Research Institute, Inc. Compositions and methods for treating musculoskeletal diseases and disorders
GB201400598D0 (en) * 2014-01-14 2014-03-05 Univ Glasgow Materials and methods for modulation of tendon healing
US9376681B2 (en) 2014-09-08 2016-06-28 MiRagen Therapeutics, Inc. miR-29 mimics and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2331143A2 (en) * 2008-09-04 2011-06-15 Universität Zürich Prorektorat Mnw Treatment of scleroderma
WO2013142336A1 (en) * 2012-03-21 2013-09-26 Miller Leonard B Combination therapy to improve joint, tendon, and ligament healing

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHANG,T.C. 等: "GenBank 登录号：EU154353.1", 《NCBI》 *
D MOULIN 等: "miR-29b is overexpressed in osteoarthritic patients and targets type II collagen", 《OSTEOARTHRITIS & CARTILAGE》 *
NEAL LINDSAY MILLAR: "The role of inflammation and cytokines in the pathogenesis of tendinopathy", 《UNIVERSITY OF GLASGOW》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112080568A (zh) * 2020-09-27 2020-12-15 扬州大学 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用

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