CN106047698A - Multifunctional head for cell culture device and cell culture device - Google Patents
Multifunctional head for cell culture device and cell culture device Download PDFInfo
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- CN106047698A CN106047698A CN201610541183.7A CN201610541183A CN106047698A CN 106047698 A CN106047698 A CN 106047698A CN 201610541183 A CN201610541183 A CN 201610541183A CN 106047698 A CN106047698 A CN 106047698A
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- module
- function head
- cell culture
- liquid
- culture plate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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Abstract
The invention relates to the technical field of biological medicine, in particular to a multifunctional head for the cell culture device and the cell culture device. The multifunctional head comprises a clone obtaining needle module, a liquid moving and changing needle module, a culture plate grabbing module, a liquid level detection module and a driving module. According to the multifunctional head, various functions of liquid moving and changing, clone obtaining, cell culture plate picking and placing, detection of liquid level of a cell culture medium in the cell culture plate and the like can be achieved simultaneously, and full automation of the cell culture device is achieved.
Description
Technical field
The present invention relates to biomedicine technical field, particularly to a kind of cell culture system multi-function head.
Background technology
When cell is cultivated, biology and the important technology of medical domain, its objective is to make cell give birth under in vitro conditions
Length and breeding.Biological cell culture apparatus is then the common biochemical instrument of a kind of cultivation for cell.Existing biological training
Supporting box structure relatively simple, function is the most single, it is difficult to realize full-automatic operation.
Summary of the invention
It is contemplated that overcome the defect of prior art, it is provided that a kind of cell culture system multi-function head and cell are cultivated
Device.
For achieving the above object, the present invention is by the following technical solutions:
On the one hand, the present invention provides a kind of cell culture system multi-function head, multi-function head include cloning acquisition module,
Move liquid change liquid module, culture plate handling module, Level Detection module and drive module；Described clone's acquisition module includes clone
Obtain pin, be used for obtaining clone；Described shifting liquid changes liquid module and includes that moving liquid changes liquid pin, is used for moving liquid and changes liquid；Described clone obtains
Pin changes liquid pin with described shifting liquid and is arranged side by side；Described culture plate handling module is used for migratory cell culture plate；Described Level Detection
Module is for detecting the liquid level of cell culture medium；Described driving module is used for driving described multi-function head to move.
Preferably, described multi-function head can move three dimensions.
Preferably, described multi-function head also includes that visual surveillance module, described visual surveillance module are used for following the tracks of described many
The position of functional head, and monitor the situation of work top in cell culture system.
Preferably, described multi-function head also includes coded scanning module, for obtaining the coding information on Tissue Culture Plate.
Preferably, described multi-function head also includes wind speed measurement module, for detecting the wind speed around Tissue Culture Plate, and
Control the wind speed around described Tissue Culture Plate in the range of 0.4m/s-0.8m/s.
Preferably, described wind speed measurement module includes two air velocity transducers.
Preferably, described multi-function head also includes that cell imaging supplementary module, described cell imaging supplementary module include light
Source, described light source is stroboscopic light.
Preferably, described Level Detection module includes ultrasonic sensor.
Preferably, described driving module includes cylinder and piston.
On the other hand, the present invention provides a kind of cell culture system, including above-mentioned multi-function head.
The beneficial effects of the present invention is: a kind of simple in construction is provided, be provided simultaneously with moving liquid and change liquid, acquisition clone, pick and place
The cell culture system multi-function head of the various functions such as liquid level of cell culture medium in Tissue Culture Plate, detection Tissue Culture Plate
And cell culture system.
Accompanying drawing explanation
Fig. 1 is the perspective view of the multi-function head according to one embodiment of the invention.
Fig. 2 is the perspective view of another angle of multi-function head according to one embodiment of the invention.
Drawing reference numeral:
Clone's acquisition pin 1, ultrasonic sensor 2, shifting liquid change liquid pin 3, handgrip 4, camera 5, code reader 6, light source 7, move liquid
Pump 8, distributing valve 9, air velocity transducer 10.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawing and be embodied as
Example, is further elaborated to the present invention.Should be appreciated that specific embodiment described herein is only in order to explain this
Bright, and be not construed as limiting the invention.
With reference first to Fig. 1 and Fig. 2, it is shown that cell culture system multi-function head is vertical according to an embodiment of the invention
Body structural representation.
Multi-function head include clone acquisition module, move liquid change liquid module, culture plate handling module, Level Detection module and
Drive module.
Wherein, driving module to be used for driving multi-function head to move, whole multi-function head can be at X-axis, Y-axis and Z axis three
Move in dimension.Drive module can include cylinder and piston, can be other structures realizing driving function.
Clone's acquisition module includes that clone obtains pin 1, is used for obtaining clone；Shifting liquid changes liquid module and includes that moving liquid changes liquid pin 3,
Liquid is changed for moving liquid.Clone obtains pin 1 and moves liquid and change liquid pin 3 quantity identical, can be respectively one, the most multiple, has
Body can include 4,6 or 8 etc..Multiple clones obtain pins 1 and change with multiple shifting liquid that liquid pin 3 is relative to be arranged side by side, and clone obtains
Taking pin 1 and shifting liquid changes the distance between liquid pin 3 and can determine according to the size of Tissue Culture Plate, clone obtains pin 1 and changes liquid with moving liquid
Pin 3 all can move up and down.
Shifting liquid changes liquid module and also includes moving liquid pump 8, moves liquid pump 8 by driving the cylinder in module to promote, and drive moves liquid and changes
Liquid pin 3 moves up and down, thus realizes extraction and the discharge of liquid.In specific embodiment, drive module can include 9 gas
Cylinder, is respectively used to drive the parts motion that in multi-function head, each are different.It addition, as shown in Figure 2, multi-function head also includes point
Joining valve 9, the distribution obtaining pin 1 outer shroud stamping-out liquid for realizing clone controls.
Culture plate handling module is used for migratory cell culture plate, specifically can include the handgrip 4 shown in figure, at multi-function head
In work process, handgrip 4 is used for capturing Tissue Culture Plate, puts down Tissue Culture Plate after being moved into desired location.
Multi-function head also includes visual surveillance module and cell imaging supplementary module.Wherein, visual surveillance module for
The position of multi-function head described in track, and monitor the situation of work top in cell culture system, specifically can include camera 5；Carefully
Born of the same parents' imaging supplementary module can include light source 7, and light source 7 can be stroboscopic light, supports the use with camera 5, for cell imaging mistake
Illumination in journey.Meanwhile, camera 5 is also used for monitoring the various situations of the work top of cell culture system, such as, at handgrip 4
Before capturing Tissue Culture Plate, camera 5 can be first passed through and judge the position of Tissue Culture Plate, then capture.
Level Detection module is used for detecting in Tissue Culture Plate, the liquid level of cell culture medium, specifically can include shown in figure
Ultrasonic sensor 2.
Multi-function head also includes coded scanning module, and as depicted in figs. 1 and 2, coded scanning module can include code reader 6,
For obtaining the coding information on Tissue Culture Plate, specifically include the 2 D code information or bar code being marked on Tissue Culture Plate
Information etc..
Multi-function head also includes that wind speed measurement module, wind speed measurement module can include air velocity transducer 10, is used for detecting carefully
Wind speed around born of the same parents' culture plate, by detection and the control of wind speed, it is possible in further control cell culture system, air is clean
Cleanliness.In preferred embodiment, wind speed measurement module includes two air velocity transducers 10, is separately positioned on multi-functional the same side
Two ends, it is possible to make wind speed measurement more accurate.In preferred embodiment, wind speed measurement module controls around Tissue Culture Plate
Wind speed in the range of 0.4m/s-0.8m/s, it is furthermore preferred that controlled wind speed is at 0.5m/s.
The present invention also provides for a kind of cell culture system, including above-mentioned multi-function head.
Multi-function head simple in construction provided by the present invention, is provided simultaneously with moving liquid and changes liquid, acquisition clone, picks and places cell cultivation
The various functions such as the liquid level of cell culture medium, detection blast velocity control air purity in plate, detection Tissue Culture Plate.Make to use
The cell culture system of this structure multifunctional head is capable of full-automation.
The detailed description of the invention of present invention described above, is not intended that limiting the scope of the present invention.Any basis
Various other done by the technology design of the present invention change and deformation accordingly, should be included in the guarantor of the claims in the present invention
In the range of protecting.
Claims (10)
1. a cell culture system multi-function head, it is characterised in that described multi-function head includes cloning acquisition module, moving liquid
Change liquid module, culture plate handling module, Level Detection module and drive module；
Described clone's acquisition module includes that clone obtains pin, is used for obtaining clone；
Described shifting liquid changes liquid module and includes that moving liquid changes liquid pin, is used for moving liquid and changes liquid；
Described clone's acquisition pin changes liquid pin with described shifting liquid and is arranged side by side；
Described culture plate handling module is used for migratory cell culture plate；
Described Level Detection module is used for detecting in Tissue Culture Plate, the liquid level of cell culture medium；
Described driving module is used for driving described multi-function head to move.
2. multi-function head as claimed in claim 1, it is characterised in that described multi-function head can move three dimensions.
3. multi-function head as claimed in claim 1, it is characterised in that described multi-function head also includes visual surveillance module, institute
State visual surveillance module for following the tracks of the position of described multi-function head, and monitor the feelings of work top in cell culture system
Condition.
4. multi-function head as claimed in claim 1, it is characterised in that described multi-function head also includes coded scanning module, uses
In the coding information obtained on Tissue Culture Plate.
5. multi-function head as claimed in claim 1, it is characterised in that described multi-function head also includes wind speed measurement module, uses
Wind speed around detection Tissue Culture Plate, and control the model at 0.4m/s-0.8m/s of the wind speed around described Tissue Culture Plate
In enclosing.
6. multi-function head as claimed in claim 5, it is characterised in that described wind speed measurement module includes two wind speed sensings
Device.
7. multi-function head as claimed in claim 1, it is characterised in that described multi-function head also includes that cell imaging assists mould
Block, described cell imaging supplementary module includes that light source, described light source are stroboscopic light.
8. multi-function head as claimed in claim 1, it is characterised in that described Level Detection module includes ultrasonic sensor.
9. multi-function head as claimed in claim 1, it is characterised in that described driving module includes cylinder and piston.
10. a cell culture system, it is characterised in that described cell culture system includes any one in claim 1-9
Described multi-function head.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610541183.7A CN106047698A (en) | 2016-07-11 | 2016-07-11 | Multifunctional head for cell culture device and cell culture device |
| PCT/CN2017/083415 WO2017202192A1 (en) | 2016-05-27 | 2017-05-08 | Multi-purpose tool tip for stem cell induction and culturing apparatus, and stem cell induction and culturing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610541183.7A CN106047698A (en) | 2016-07-11 | 2016-07-11 | Multifunctional head for cell culture device and cell culture device |
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| Publication Number | Publication Date |
|---|---|
| CN106047698A true CN106047698A (en) | 2016-10-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610541183.7A Pending CN106047698A (en) | 2016-05-27 | 2016-07-11 | Multifunctional head for cell culture device and cell culture device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017202192A1 (en) * | 2016-05-27 | 2017-11-30 | 中国科学院广州生物医药与健康研究院 | Multi-purpose tool tip for stem cell induction and culturing apparatus, and stem cell induction and culturing apparatus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106584A (en) * | 1984-09-18 | 1992-04-21 | Sumitomo Electric Industries, Ltd. | Cell selecting apparatus |
| WO2008083439A1 (en) * | 2007-01-12 | 2008-07-17 | Labtech Systems Limited | Method and apparatus for inoculating and streaking a medium in a plate |
| CN102174395A (en) * | 2011-01-30 | 2011-09-07 | 中国科学院广州生物医药与健康研究院 | Automation augmentation and culture system of induced pluripotent stem cells |
-
2016
- 2016-07-11 CN CN201610541183.7A patent/CN106047698A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106584A (en) * | 1984-09-18 | 1992-04-21 | Sumitomo Electric Industries, Ltd. | Cell selecting apparatus |
| WO2008083439A1 (en) * | 2007-01-12 | 2008-07-17 | Labtech Systems Limited | Method and apparatus for inoculating and streaking a medium in a plate |
| CN102174395A (en) * | 2011-01-30 | 2011-09-07 | 中国科学院广州生物医药与健康研究院 | Automation augmentation and culture system of induced pluripotent stem cells |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017202192A1 (en) * | 2016-05-27 | 2017-11-30 | 中国科学院广州生物医药与健康研究院 | Multi-purpose tool tip for stem cell induction and culturing apparatus, and stem cell induction and culturing apparatus |
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