CN106039168A - Pharmaceutical composition for enhancing immunity and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for enhancing immunity and preparation method of pharmaceutical composition Download PDFInfo
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- CN106039168A CN106039168A CN201610403697.6A CN201610403697A CN106039168A CN 106039168 A CN106039168 A CN 106039168A CN 201610403697 A CN201610403697 A CN 201610403697A CN 106039168 A CN106039168 A CN 106039168A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A61K36/55—Linaceae (Flax family), e.g. Linum
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
This invention relates to pharmaceutical composition for enhancing immunity and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following medicines in parts by weight: Kaempferia galanga, Aegle marmelos, potassium nitrate, Chinese angelica, Radix Semiaquilegiae, Carolina Cranesbill herb, linseed, mustard seed, Japanese honeysuckle stem, dogbane leaf, Rangoon Creeper and licorice root through water extraction and ethanol extraction. Results of experiments on hypoxia tolerance time of mice under normal pressure and burden swimming time of mice show that the survival time of an experimented group in the hypoxic environment and in the burden swimming experiment is significantly longer than that of a control group, so that the pharmaceutical composition has significant enhancing effects on hypoxia tolerance and fatigue resistance of the mice; clinical observation results show that the average effective rate of 270 patients reaches 94.07%, illustrating that the pharmaceutical composition is worth promoting in enhancement of immunity.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to pharmaceutical composition and the preparation side thereof of a kind of enhancing immunity
Method.
Background technology
Immunity is the defense mechanism of human body self, is that any foreign body of human bioequivalence and the external intrusion of elimination is (viral, thin
Bacterium etc.)；Process aging, damage, dead, the own cells of degeneration and identification and process vivo mutations cell and virus infects carefully
The ability of born of the same parents.Immunology Today is thought, immunity is human bioequivalence and the physiological reaction getting rid of " dissident ".This is performed in human body
Function is immune system.Over millions of years, human lives is at an environment being not only suitable for existence but also being fraught with risks, and the mankind are able to
Survival, also obtain outstanding immunity.Immunity is the product of biological evolution process thus.But it is as sending out of society
Exhibition, it is the most increasing that the live and work pressure of people becomes, and causes physical function to decline therewith, causes body immunity low
Under.The health of hypoimmunity easily causes antibacterial, virus, fungus etc. to be infected, and therefore hypoimmunity just the most directly shows
It is liable to illness.Because of the most ill, increased the weight of the consumption of body, thus typically have a delicate constitution, malnutrition, lethargy,
The reduction of fatigue and weak, appetite, sleep disorder etc. show, sick, having an injection to take medicine has become homely food.The most sick will be the longest
Time could recover, and usually recurrent exerbation.Health and intelligent development if things go on like this can be caused bad, the most easily induce great disease
Sick.
At present, market exists the health product of numerous enhancing immunity, but great majority all DeGrains or the ratio that takes effect
Slower, consumer is dissatisfied to this.
The present inventor, in order to solve the problems referred to above, have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide the pharmaceutical composition of a kind of enhancing immunity.
It is a further object of the present invention to provide the preparation method of the pharmaceutical composition of a kind of enhancing immunity.
The present invention provides the pharmaceutical composition of a kind of enhancing immunity, and this pharmaceutical composition is by the medicine system of following weight portion
Become: Rhizoma Kaempferiae 40-80 part, wood Fructus Citri tangerinae 30-70 part, Sal Nitri 10-30 part, Radix Angelicae Sinensis 50-100 part, Radix Semiaquilegiae 10-40 part, Herba Erodii 10-40
Part, Semen Lini 20-60 part, Semen Sinapis 10-40 part, Caulis Lonicerae 20-60 part, Folium Apocyni Veneti 10-50 part, Fructus Quisqualis 10-50 part, Radix Glycyrrhizae
20-50 part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Rhizoma Kaempferiae 45-75 part, wood Fructus Citri tangerinae
35-65 part, Sal Nitri 12-28 part, Radix Angelicae Sinensis 60-90 part, Radix Semiaquilegiae 13-37 part, Herba Erodii 15-35 part, Semen Lini 25-55 part, mustard
Sub-13-37 part, Caulis Lonicerae 25-55 part, Folium Apocyni Veneti 15-45 part, Fructus Quisqualis 15-45 part, Radix Glycyrrhizae 25-45 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Rhizoma Kaempferiae 50-70
Part, wood Fructus Citri tangerinae 40-60 part, Sal Nitri 15-25 part, Radix Angelicae Sinensis 65-85 part, Radix Semiaquilegiae 18-32 part, Herba Erodii 18-32 part, Semen Lini 30-
50 parts, Semen Sinapis 15-32 part, Caulis Lonicerae 30-50 part, Folium Apocyni Veneti 20-40 part, Fructus Quisqualis 20-40 part, Radix Glycyrrhizae 28-42 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Rhizoma Kaempferiae 55-65
Part, wood Fructus Citri tangerinae 45-55 part, Sal Nitri 18-23 part, Radix Angelicae Sinensis 70-80 part, Radix Semiaquilegiae 20-30 part, Herba Erodii 20-30 part, Semen Lini 35-
45 parts, Semen Sinapis 20-29 part, Caulis Lonicerae 35-45 part, Folium Apocyni Veneti 25-35 part, Fructus Quisqualis 25-35 part, Radix Glycyrrhizae 31-39 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Rhizoma Kaempferiae 60 parts,
Wood Fructus Citri tangerinae 50 parts, Sal Nitri 20 parts, Radix Angelicae Sinensis 75 parts, Radix Semiaquilegiae 25 parts, Herba Erodii 25 parts, Semen Lini 40 parts, 25 parts of Semen Sinapis, Caulis Lonicerae 40
Part, Folium Apocyni Veneti 30 parts, Fructus Quisqualis 30 parts, 35 parts of Radix Glycyrrhizae.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, described solid preparation be tablet, capsule,
Granule or pill；Described liquid preparation is oral liquid.
Pharmaceutical composition preparation method of the present invention comprises the following steps: by Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae
Son, Herba Erodii, Semen Lini, Semen Sinapis, Caulis Lonicerae, Folium Apocyni Veneti, Fructus Quisqualis, Radix Glycyrrhizae pulverize and sieve, with pharmaceutically acceptable load
Body or diluent mix homogeneously, be prepared as preparation.
Pharmaceutical composition preparation method of the present invention comprises the following steps:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 3-5 times amount water heating and refluxing extraction 1-3 time,
1-3 hour every time, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 2-4 times amount soak with ethanol 3-5 hour, mistake
Filter, filtrate concentrate drying, it is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing
Uniformly, preparation is made.
Preferably, pharmaceutical composition preparation method of the present invention comprises the following steps:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing
Uniformly, preparation is made.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, selected from filler,
One or more in binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or Portugal
Grape sugar etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or stearic acid
Magnesium；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fat
Fat acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method have the advantages that
Test by measuring the time of mice oxygen deficit tolerance and swimming with a load attached to the body, test result indicate that drug regimen of the present invention
Tested group of thing time-to-live in anaerobic environment and swimming with a load attached to the body are tested is considerably longer than matched group, has significantly enhancing mice resistance to
Anoxia and anti-fatigue ability；Being shown by clinical observation result, in 270 example patients, total effective rate averagely reaches 94.07%, says
The bright present invention increases immunity aspect and is worthy to be popularized.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Rhizoma Kaempferiae 40g, wood Fructus Citri tangerinae 30g, Sal Nitri 10g, Radix Angelicae Sinensis 50g, Radix Semiaquilegiae 10g, Herba Erodii 10g, Semen Lini 20g, mustard
Sub-10g, Caulis Lonicerae 20g, Folium Apocyni Veneti 10g, Fructus Quisqualis 10g, Radix Glycyrrhizae 20g.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 3 times amount water heating and refluxing extraction 1 time, each 1
Hour, filter, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 2 times amount soak with ethanol 3 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dress
Enter capsule, make capsule.
Embodiment 2
Prescription: Rhizoma Kaempferiae 80g, wood Fructus Citri tangerinae 70g, Sal Nitri 30g, Radix Angelicae Sinensis 100g, Radix Semiaquilegiae 40g, Herba Erodii 40g, Semen Lini 60g,
Semen Sinapis 40g, Caulis Lonicerae 60g, Folium Apocyni Veneti-50g, Fructus Quisqualis 50g, Radix Glycyrrhizae 50g.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 5 times amount water heating and refluxing extraction 3 times, each 3
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 4 times amount soak with ethanol 5 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dry
Dry, tabletting, obtain the tablet of the application.
Embodiment 3
Prescription: Rhizoma Kaempferiae 45 parts, wood Fructus Citri tangerinae 35 parts, Sal Nitri 12 parts, Radix Angelicae Sinensis 60 parts, Radix Semiaquilegiae 13 parts, Herba Erodii 15 parts, Semen Lini
25 parts, 13 parts of Semen Sinapis, Caulis Lonicerae 25 parts, Folium Apocyni Veneti 15 parts, Fructus Quisqualis 15 parts, 25 parts of Radix Glycyrrhizae.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dress
Enter capsule, make capsule.
Embodiment 4
Prescription: Rhizoma Kaempferiae 75 parts, wood Fructus Citri tangerinae 65 parts, Sal Nitri 28 parts, Radix Angelicae Sinensis 90 parts, Radix Semiaquilegiae 37 parts, Herba Erodii 35 parts, Semen Lini
55 parts, 37 parts of Semen Sinapis, Caulis Lonicerae 55 parts, Folium Apocyni Veneti 45 parts, Fructus Quisqualis 45 parts, 45 parts of Radix Glycyrrhizae.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 5 times amount water heating and refluxing extraction 3 times, each 3
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 4 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dry
Dry, tabletting, obtain the tablet of the application.
Embodiment 5
Prescription: Rhizoma Kaempferiae 50g, wood Fructus Citri tangerinae 40g, Sal Nitri 15g, Radix Angelicae Sinensis 65g, Radix Semiaquilegiae 18g, Herba Erodii 18g, Semen Lini 30g, mustard
Sub-15g, Caulis Lonicerae 30g, Folium Apocyni Veneti 20g, Fructus Quisqualis 20g, Radix Glycyrrhizae 28g.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dress
Enter capsule, make capsule.
Embodiment 6
Prescription: Rhizoma Kaempferiae 70g, wood Fructus Citri tangerinae 60g, Sal Nitri 25g, Radix Angelicae Sinensis 85g, Radix Semiaquilegiae 32g, Herba Erodii 32g, Semen Lini 50g, mustard
Sub-32g, Caulis Lonicerae 50g, Folium Apocyni Veneti 40g, Fructus Quisqualis-40g, Radix Glycyrrhizae 42g.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, mixed
Even, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 7
Prescription: Rhizoma Kaempferiae 55 parts, wood Fructus Citri tangerinae 45 parts, Sal Nitri 18 parts, Radix Angelicae Sinensis 70 parts, Radix Semiaquilegiae 20 parts, Herba Erodii 20 parts, Semen Lini
35 parts, 20 parts of Semen Sinapis, Caulis Lonicerae 35 parts, Folium Apocyni Veneti 25 parts, Fructus Quisqualis 25 parts, 31 parts of Radix Glycyrrhizae.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dress
Enter capsule, make capsule.
Embodiment 8
Prescription: Rhizoma Kaempferiae 65 parts, wood Fructus Citri tangerinae 55 parts, Sal Nitri 23 parts, Radix Angelicae Sinensis 80 parts, Radix Semiaquilegiae 30 parts, Herba Erodii 30 parts, Semen Lini
45 parts, 29 parts of Semen Sinapis, Caulis Lonicerae 45 parts, Folium Apocyni Veneti 35 parts, Fructus Quisqualis 35 parts, 39 parts of Radix Glycyrrhizae.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dry
Dry, tabletting, obtain the tablet of the application.
Embodiment 9
Prescription: Rhizoma Kaempferiae 60g, wood Fructus Citri tangerinae 50g, Sal Nitri 20g, Radix Angelicae Sinensis 75g, Radix Semiaquilegiae 25g, Herba Erodii 25g, Semen Lini 40g, mustard
Sub-25g, Caulis Lonicerae 40g, Folium Apocyni Veneti 30g, Fructus Quisqualis 30g, Radix Glycyrrhizae 35g.
Preparation method:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add the starch accounting for mix homogeneously fine powder weight 1/5, dress
Enter capsule, make capsule.
In order to sketch beneficial effects of the present invention further, inventor has done anoxia enduring and the experimentation of resisting fatigue and has faced
Bed test, specific as follows:
One, anoxia enduring and the experiment of resisting fatigue
Test medicine: embodiment 1 pharmaceutical composition of the present invention.
Laboratory animal: choose healthy kunming mice 560, male and female half and half, body weight (20 ± 2) g.
Experimental technique:
28 groups will be randomly divided into, often group 10 after mouse weights.It is respectively blank group and embodiment of the present invention 1
Pharmaceutical composition high, medium and low dosage group.Blank group gavage 0.1ml/10g every day body weight pure water；Every test mice is by this
Invent the described basic, normal, high dosage component of pharmaceutical composition embodiment 1 do not give pharmaceutical composition 10mg/kg, 20mg/kg,
40mg/kg, blank group gavage 0.1ml/10g every day pure water, continuous gavage 14 days, 1 time/d.
Mice oxygen deficit tolerance is tested: after mice last gavage 4h, and often 10 mices of group, are respectively placed in mice equipped with sodium
In the airtight wide mouthed bottle of 125ml of Calx 7.5g, after sealing, its time-to-live of observed and recorded, refer to respiratory arrest for death
Levy.
Mice burden swimming is tested: after mice last gavage 4h, and often 10 mices of group, are it in every mouse tail system one
The weight of weight 5%, puts into the swimming trunk went swimming of 110cm × 60cm × 70cm, depth of water 20cm, and water temperature is 30 ± 0.5 DEG C,
All enter the lasting 8s of water with mouse head and can not emerge as judging terminal, the record swimming exhaustion time.
All experimental datas represent with average and standard deviation, carry out t inspection and variance analysis.
Experimental result: the embodiment of the present invention 1 pharmaceutical composition is shown in Table 1 to the impact of mice oxygen deficit tolerance time-to-live,
Compared with matched group, pharmaceutical composition test mice fur of the present invention light, the most active, none animal dead.
Basic, normal, high dosage group all can significantly improve mice oxygen deficit tolerance ability.Wherein improve hypoxia-bearing capability with middle dosage group
For significantly, show dose-effect relationship.The impact on the mice oxygen deficit tolerance time-to-live of table 1 pharmaceutical composition of the present invention
Pharmaceutical composition of the present invention is shown in Table 2 to the impact of mice burden swimming time.Compared with matched group, the present invention
Described pharmaceutical composition basic, normal, high dosage group all can significantly improve mice burden swimming ability, when extending mice burden swimming
Between.Wherein improve mice burden swimming ability with middle dosage group the most notable, show dose-effect relationship.
The impact on the mice burden swimming time of table 2 pharmaceutical composition of the present invention
Measure mice oxygen deficit tolerance and the time of swimming with a load attached to the body, be that assessment body supplies deficiency state at absolute oxygen respectively
Under, anoxia enduring and the common method of anti-fatigue ability.Test result indicate that tested group of pharmaceutical composition of the present invention is in anaerobic environment
In testing with swimming with a load attached to the body, the time-to-live is considerably longer than matched group, has and significantly strengthens mice anoxia enduring and anti-fatigue ability,
There is higher value of exploiting and utilizing.
Two, clinical observation
1. clinical data: choosing 270 example immunocompromised patients altogether is treatment target, the maleest 100 people, female 170 people, year
Age is 10-55 year, average 38 years old.
2. efficacy assessment standard
(1) effective: body constitution is remarkably reinforced, extremity are strong, energetic, and face improves, and sleep and the Asia of the aspect such as digestion
Health status is obviously improved；
(2) effective: body constitution has strengthened, and extremity are more powerful, and energy and face have taken a turn for the better, sleep and the aspect such as digestion
Subhealth state shape also make moderate progress；
(3) invalid: symptom and every inspection have no improvement.
3. Therapeutic Method: the pharmaceutical composition of oral embodiment of the present invention 1-9, every day twice sooner or later, each 4g, after meal temperature
Water delivery service, takes 1 month altogether.
4. therapeutic outcome:
| Group | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 20 | 7 | 3 | 30 | 90.0% |
| Embodiment 2 | 22 | 6 | 2 | 30 | 93.3% |
| Embodiment 3 | 24 | 4 | 2 | 30 | 93.3% |
| Embodiment 4 | 23 | 6 | 1 | 30 | 96.7% |
| Embodiment 5 | 21 | 7 | 2 | 30 | 93.3% |
| Embodiment 6 | 23 | 6 | 1 | 30 | 96.7% |
| Embodiment 7 | 21 | 7 | 2 | 30 | 93.3% |
| Embodiment 8 | 24 | 4 | 2 | 30 | 93.3% |
| Embodiment 9 | 23 | 6 | 1 | 30 | 96.7% |
Clinical observation result shows, in 270 example patients, total effective rate averagely reaches 94.07%.
In a word, by measuring mice oxygen deficit tolerance and the time of swimming with a load attached to the body, test result indicate that medicine group of the present invention
Tested group of compound time-to-live in anaerobic environment and swimming with a load attached to the body are tested is considerably longer than matched group, has and significantly strengthens mice
Anoxia enduring and anti-fatigue ability；Being shown by clinical observation result, in 270 example patients, total effective rate averagely reaches 94.07%,
Illustrate that the present invention increases immunity aspect and is worthy to be popularized.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, it can be made some amendments or improve, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. the pharmaceutical composition of an enhancing immunity, it is characterised in that this pharmaceutical composition is by the medicine system of following weight portion
Become: Rhizoma Kaempferiae 40-80 part, wood Fructus Citri tangerinae 30-70 part, Sal Nitri 10-30 part, Radix Angelicae Sinensis 50-100 part, Radix Semiaquilegiae 10-40 part, Herba Erodii 10-40
Part, Semen Lini 20-60 part, Semen Sinapis 10-40 part, Caulis Lonicerae 20-60 part, Folium Apocyni Veneti 10-50 part, Fructus Quisqualis 10-50 part, Radix Glycyrrhizae
20-50 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Rhizoma Kaempferiae 45-75 part, wood Fructus Citri tangerinae 35-65 part, Sal Nitri 12-28 part, Radix Angelicae Sinensis 60-90 part, Radix Semiaquilegiae 13-37 part, Herba Erodii 15-
35 parts, Semen Lini 25-55 part, Semen Sinapis 13-37 part, Caulis Lonicerae 25-55 part, Folium Apocyni Veneti 15-45 part, Fructus Quisqualis 15-45 part, sweet
Grass 25-45 part.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Rhizoma Kaempferiae 50-70 part, wood Fructus Citri tangerinae 40-60 part, Sal Nitri 15-25 part, Radix Angelicae Sinensis 65-85 part, Radix Semiaquilegiae 18-32 part, Herba Erodii 18-
32 parts, Semen Lini 30-50 part, Semen Sinapis 15-32 part, Caulis Lonicerae 30-50 part, Folium Apocyni Veneti 20-40 part, Fructus Quisqualis 20-40 part, sweet
Grass 28-42 part.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Rhizoma Kaempferiae 55-65 part, wood Fructus Citri tangerinae 45-55 part, Sal Nitri 18-23 part, Radix Angelicae Sinensis 70-80 part, Radix Semiaquilegiae 20-30 part, Herba Erodii 20-
30 parts, Semen Lini 35-45 part, Semen Sinapis 20-29 part, Caulis Lonicerae 35-45 part, Folium Apocyni Veneti 25-35 part, Fructus Quisqualis 25-35 part, sweet
Grass 31-39 part.
Pharmaceutical composition the most according to claim 4, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Rhizoma Kaempferiae 60 parts, wood Fructus Citri tangerinae 50 parts, Sal Nitri 20 parts, Radix Angelicae Sinensis 75 parts, Radix Semiaquilegiae 25 parts, Herba Erodii 25 parts, Semen Lini 40 parts, mustard
Son 25 parts, Caulis Lonicerae 40 parts, Folium Apocyni Veneti 30 parts, Fructus Quisqualis 30 parts, 35 parts of Radix Glycyrrhizae.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this pharmaceutical composition is possibly together with pharmacy
Upper acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition is solid preparation or liquid
Preparation, described solid preparation is tablet, capsule, granule or pill；Described liquid preparation is oral liquid.
8. the method for the pharmaceutical composition prepared described in any one of claim 1-5, it is characterised in that the method include with
Lower step: by Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii, Semen Lini, Semen Sinapis, Caulis Lonicerae, Folium Apocyni Veneti, make monarch
Son, Radix Glycyrrhizae pulverize and sieve, and mix homogeneously with pharmaceutically acceptable carrier or diluent, are prepared as preparation.
9. prepare the method for pharmaceutical composition described in any one of claim 1-5 for one kind, it is characterised in that the method includes following
Step:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 3-5 times amount water heating and refluxing extraction 1-3 time, every time
1-3 hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder are broken into fine powder, add 2-4 times amount soak with ethanol 3-5 hour, filter, filter
Liquid concentrate drying, is ground into fine powder standby；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing all
Even, make preparation.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that the method comprises the following steps:
1) by Folium Apocyni Veneti, that Fructus Quisqualis powder is broken into fine powder is standby；
2) Rhizoma Kaempferiae, wood Fructus Citri tangerinae, Sal Nitri, Radix Angelicae Sinensis, Radix Semiaquilegiae, Herba Erodii are added 4 times amount water heating and refluxing extraction 2 times, each 2 little
Time, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；
3) Semen Lini, Semen Sinapis, Caulis Lonicerae, Radix Glycyrrhizae powder being broken into fine powder, add 3 times amount soak with ethanol 4 hours, filter, filtrate is dense
It is standby that contracting dry, pulverize into fine powder；
4) by step 1), 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing all
Even, make preparation.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156919A (en) * | 2007-09-15 | 2008-04-09 | 马秀英 | Compositions of A-beta peptide and preparation method |
| CN101683427A (en) * | 2008-09-23 | 2010-03-31 | 华北制药集团新药研究开发有限责任公司 | Traditional Chinese medicine composition and preparation method thereof |
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
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2016
- 2016-06-03 CN CN201610403697.6A patent/CN106039168A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156919A (en) * | 2007-09-15 | 2008-04-09 | 马秀英 | Compositions of A-beta peptide and preparation method |
| CN101683427A (en) * | 2008-09-23 | 2010-03-31 | 华北制药集团新药研究开发有限责任公司 | Traditional Chinese medicine composition and preparation method thereof |
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
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Application publication date: 20161026 |