CN106039069A - Anti-metastasis traditional Chinese medicine preparation and method of preparing same - Google Patents
Anti-metastasis traditional Chinese medicine preparation and method of preparing same Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 239000003814 drug Substances 0.000 title claims abstract description 42
- 230000002001 anti-metastasis Effects 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title abstract description 3
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 16
- 241000628997 Flos Species 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 241000272188 Accipiter Species 0.000 claims description 15
- 235000021551 crystal sugar Nutrition 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 15
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 7
- 241000272189 Accipiter gentilis Species 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 238000011281 clinical therapy Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 206010027476 Metastases Diseases 0.000 description 6
- 230000009401 metastasis Effects 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000000496 gastric squamous cell carcinoma Diseases 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses an anti-metastasis traditional Chinese medicine preparation and method of preparing the same. The anti-metastasis traditional Chinese medicine preparation is prepared from the following medicinal materials according to parts by weight: 5-12 parts of Rhizoma seu Radix Notopterygii, 6-12 parts of Radix Puerariae, 13-15 parts of Herba Lophatheri, 10-14 parts of Fructus Acronychiae Pedunculatae, 15-22 parts of Fructus Arctii, 4-8 parts of Flos Chrysanthemi, 9-12 parts of Herba Menthae, 12-16 parts of Radix Siegesbeckiae, 1-5 parts of Accipiter gentilis head, and 15-18 parts of rock candy; compared with the prior art, the invention has the advantages that on one hand, the preparation has significant efficacy, low price and zero toxic and side effect and never causes patient dependence on drugs , and ensures rare recurrence; on the other hand, the preparation is simple to prepare and administer and is suitable for large-scale industrial application and clinical therapy application.
Description
Technical field
The present invention relates to Chinese medicine preparation and preparation method thereof, particularly relate to Chinese medicine preparation and the system thereof of a kind of anti metastasis
Preparation Method.
Background technology
Tumor is commonly encountered diseases, frequently-occurring disease, and wherein malignant tumor is the class disease that harm human health is the most serious at present. or not
The only mankind suffer from tumor, and animal and plant also have tumor.Tumor be body under various tumorigenesis factor effects, the cell of local organization exists
Lose the regulation and control that it is grown on gene level, cause monoclonicity paraplasm and the neoplasm that formed.This neoplasm is normal
Form local lump, thus gain the name.
There is local infiltration and metastasis is the most important feature of malignant tumor, and be malignant tumor causing death
Main cause.For tumor patient, current modal Therapeutic Method is chemotherapy and operation combines, its therapeutic process quite pain
Hardship, and effect is general, the most also has the proposition of some Chinese medicine preparation, but there is decoction process complexity, poor effect, or
Effect is not notable, or the problem of easily recurrence.
Summary of the invention
Goal of the invention: in order to solve the problem existing for prior art, the invention provides that a kind of drug effect is notable, low cost
Honest and clean, taking convenience, the Chinese medicine preparation of anti metastasis being difficult to recurrence and preparation method thereof.
Technical scheme: for reaching above-mentioned purpose, the present invention by the following technical solutions:
The Chinese medicine preparation of a kind of anti metastasis, including the crude drug of preparing of following parts by weight: Rhizoma Et Radix Notopterygii 5-12 part, Radix Puerariae
6-12 part, Herba Lophatheri 13-15 part, Acronychi apedunculata (L.) Miq. 10-14 part, Fructus Arctii 15-22 part, Flos Chrysanthemi 4-8 part, Herba Menthae 9-12 part, Xian root
12-16 part, Caput Accipiter 1-5 part, crystal sugar 15-18 part.
The invention allows for the preparation method of the Chinese medicine preparation of above-mentioned anti metastasis, comprise the following steps:
(1) all crude drug are got ready clean according to institute's expense；
(2) first Rhizoma Et Radix Notopterygii carries out the soak extraction of 30min with the chloroform of 2-3 times of quality, and Radix Puerariae, Herba Lophatheri are with 2-3 times
The dehydrated alcohol of quality carries out the soak extraction of 45min, and the citric acid of 2-3 times of quality of Acronychi apedunculata (L.) Miq. carries out the immersion of 45min and carries
Taking, the extracting solution mix homogeneously after extracting is stand-by；
(3) Fructus Arctii, Flos Chrysanthemi, Herba Menthae, Xian root, Caput Accipiter, crystal sugar are crushed to respectively after 1cm by respective quality 4-5 times
Deionized water submergence standby；
(4) first Xian root, Caput Accipiter big fire boil rear slow fire continue to decoct 30min to leach medicinal liquid standby, obtain filtering residue；
(5) adding Flos Chrysanthemi, Herba Menthae, Fructus Arctii and crystal sugar in the filtering residue of step (4), big fire continues to decoct after boiling
Medicinal liquid is leached standby after 25min；Abandon filtering residue；
(6) extracting solution, step (4) and the medicinal liquid mix homogeneously that (5) obtain step (2) obtained carries out being concentrated into relative
Density is 1.05, enter spray dryer, inlet temperature controls 120～130 DEG C, and leaving air temp 120～130 DEG C obtain spray drying
Powder, the Chinese medicine preparation of described anti metastasis.
Being more highly preferred to, the mass concentration of the chloroform in described step (2) is 45%-65%.
Being more highly preferred to, the mass concentration of the dehydrated alcohol in described step (2) is 60%-80%.
Being more highly preferred to, the mass concentration of the citric acid in described step (2) is 85%-95%.
Beneficial effect: Chinese medicine preparation of a kind of anti metastasis provided by the present invention and preparation method thereof, with existing skill
Art is compared and is had the advantage that on the one hand drug effect is notable, cheap, has no side effect, does not results in patient and depend on medicine
Lai Xing, is difficult to recurrence；On the other hand its preparation and instructions of taking are easy, and be suitable to large-scale industrial application and clinical treatment should
With.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described:
Embodiment 1:
The Chinese medicine preparation of a kind of anti metastasis, including the crude drug of preparing of following parts by weight: Rhizoma Et Radix Notopterygii 5 parts, Radix Puerariae 6
Part, Herba Lophatheri 13 parts, Acronychi apedunculata (L.) Miq. 10 parts, Fructus Arctii 15 parts, Flos Chrysanthemi 4 parts, Herba Menthae 9 parts, Xian root 12 parts, Caput Accipiter 1 part, crystal sugar 15
Part.
The preparation method of the Chinese medicine preparation of above-mentioned a kind of anti metastasis, comprises the following steps:
(1) all crude drug are got ready clean according to institute's expense；
(2) first Rhizoma Et Radix Notopterygii is carried out with the chloroform that mass concentration is 45% of 2 times of quality the soak extraction of 30min, Radix Puerariae,
The Herba Lophatheri dehydrated alcohol that mass concentration is 60% of 2 times of quality carries out the soak extraction of 45min, and Acronychi apedunculata (L.) Miq. is by 2 times of quality
The citric acid that mass concentration is 85% carry out the soak extraction of 45min, the extracting solution mix homogeneously after extracting is stand-by；
(3) Fructus Arctii, Flos Chrysanthemi, Herba Menthae, Xian root, Caput Accipiter, crystal sugar are crushed to respectively after 1cm by respective quality 4 times
Deionized water submergence is standby；
(4) first Xian root, Caput Accipiter big fire boil rear slow fire continue to decoct 30min to leach medicinal liquid standby, obtain filtering residue；
(5) adding Flos Chrysanthemi, Herba Menthae, Fructus Arctii and crystal sugar in the filtering residue of step (4), big fire continues to decoct after boiling
Medicinal liquid is leached standby after 25min；Abandon filtering residue；
(6) extracting solution, step (4) and the medicinal liquid mix homogeneously that (5) obtain step (2) obtained carries out being concentrated into relative
Density is 1.05, enter spray dryer, inlet temperature controls 120 DEG C, and leaving air temp 120 DEG C obtains spray drying powder,
The Chinese medicine preparation of described anti metastasis.
Embodiment 2:
The Chinese medicine preparation of a kind of anti metastasis, including the crude drug of preparing of following parts by weight: Rhizoma Et Radix Notopterygii 12 parts, Radix Puerariae 12
Part, Herba Lophatheri 15 parts, Acronychi apedunculata (L.) Miq. 14 parts, Fructus Arctii 22 parts, Flos Chrysanthemi 8 parts, Herba Menthae 12 parts, Xian root 16 parts, Caput Accipiter 5 parts, crystal sugar
18 parts.
The preparation method of the Chinese medicine preparation of above-mentioned a kind of anti metastasis, comprises the following steps:
(1) all crude drug are got ready clean according to institute's expense；
(2) first Rhizoma Et Radix Notopterygii is carried out with the chloroform that mass concentration is 65% of 3 times of quality the soak extraction of 30min, Radix Puerariae,
The Herba Lophatheri dehydrated alcohol that mass concentration is 80% of 3 times of quality carries out the soak extraction of 45min, and Acronychi apedunculata (L.) Miq. is by 3 times of quality
The citric acid that mass concentration is 95% carry out the soak extraction of 45min, the extracting solution mix homogeneously after extracting is stand-by；
(3) Fructus Arctii, Flos Chrysanthemi, Herba Menthae, Xian root, Caput Accipiter, crystal sugar are crushed to respectively after 1cm by respective quality 4-5 times
Deionized water submergence standby；
(4) first Xian root, Caput Accipiter big fire boil rear slow fire continue to decoct 30min to leach medicinal liquid standby, obtain filtering residue；
(5) adding Flos Chrysanthemi, Herba Menthae, Fructus Arctii and crystal sugar in the filtering residue of step (4), big fire continues to decoct after boiling
Medicinal liquid is leached standby after 25min；Abandon filtering residue；
(6) extracting solution, step (4) and the medicinal liquid mix homogeneously that (5) obtain step (2) obtained carries out being concentrated into relative
Density is 1.05, enter spray dryer, inlet temperature controls 130 DEG C, and leaving air temp 130 DEG C obtains spray drying powder,
The Chinese medicine preparation of described anti metastasis.
Embodiment 3:
The Chinese medicine preparation of a kind of anti metastasis, including the crude drug of preparing of following parts by weight: Rhizoma Et Radix Notopterygii 9 parts, Radix Puerariae 10
Part, Herba Lophatheri 14 parts, Acronychi apedunculata (L.) Miq. 12 parts, Fructus Arctii 19 parts, Flos Chrysanthemi 6 parts, Herba Menthae 10 parts, Xian root 14 parts, Caput Accipiter 3 parts, crystal sugar
17 parts.
The preparation method of the Chinese medicine preparation of above-mentioned a kind of anti metastasis, comprises the following steps:
(1) all crude drug are got ready clean according to institute's expense；
(2) first Rhizoma Et Radix Notopterygii is carried out with the chloroform that mass concentration is 55% of 3 times of quality the soak extraction of 30min, Radix Puerariae,
The Herba Lophatheri dehydrated alcohol that mass concentration is 70% of 3 times of quality carries out the soak extraction of 45min, and Acronychi apedunculata (L.) Miq. is by 3 times of quality
The citric acid that mass concentration is 90% carry out the soak extraction of 45min, the extracting solution mix homogeneously after extracting is stand-by；
(3) Fructus Arctii, Flos Chrysanthemi, Herba Menthae, Xian root, Caput Accipiter, crystal sugar are crushed to respectively after 1cm by respective quality 4-5 times
Deionized water submergence standby；
(4) first Xian root, Caput Accipiter big fire boil rear slow fire continue to decoct 30min to leach medicinal liquid standby, obtain filtering residue；
(5) adding Flos Chrysanthemi, Herba Menthae, Fructus Arctii and crystal sugar in the filtering residue of step (4), big fire continues to decoct after boiling
Medicinal liquid is leached standby after 25min；Abandon filtering residue；
(6) extracting solution, step (4) and the medicinal liquid mix homogeneously that (5) obtain step (2) obtained carries out being concentrated into relative
Density is 1.05, enters spray dryer, and inlet temperature controls 125 DEG C, and leaving air temp 125 DEG C obtains spray drying powder, institute
State the Chinese medicine preparation of anti metastasis.
The present invention cures mainly diffusion and the transfer of malignant tumor.It is expanded on further of the present invention below by way of mouse test
The beneficial effect of medicine:
A) test medicine: the Chinese drugs agentia that embodiment 3 prepares.
B) subjects: inbred line 615 mice, male, body weight 18～22g, 40.
C) test method and result: take after transplanting 8～10d portable before squamous cell carcinoma of stomach (FC) tissue, prepare
Become the cell suspension of 1 × 1010/L, in mice right axil subcutaneous injection cell suspension 0.2ml/ only.Divide at random after mouse inoculation tumor strain
It is 4 groups, often group 10.It is grouped and includes matched group (blank group), high dose group (20g/kg), middle dosage group (10g/kg), low dose
Amount group (5g/kg).Every treated animal is second day difference gastric infusion after connecing tumor, and by daily single, continuous 3 weeks, matched group filled
Stomach gives etc. to measure normal saline.Experiment terminates rear anatomy experiment mice, takes out lungs, counting pulmonary total metastasis number.Transfer
Stove is ecru, edge finishing, similar round tuberosity.Metastasis inhibition rate=(blank group metastasis number-administration group metastasis number)/
Blank group metastasis number × 100%.The results are shown in Table 1.
Table 1 test group and matched group comparitive study
From upper watch test data it can be seen that the Chinese medicine preparation of anti metastasis prepared of the present invention, antineoplastic is turned
Shifting has obvious curative effect, and along with the raising of dosage, curative effect strengthens, brings great Gospel to tumor patient.
It should be pointed out that, that above detailed description of the invention is merely to illustrate the present invention rather than limits the scope of the present invention,
After having read the present invention, the amendment of the various equivalent form of values of the present invention is all fallen within and weighs appended by the application by those skilled in the art
Profit requires limited range.
Claims (5)
1. the Chinese medicine preparation of an anti metastasis, it is characterised in that include the crude drug of preparing of following parts by weight: Rhizoma Et Radix Notopterygii 5-
12 parts, Radix Puerariae 6-12 part, Herba Lophatheri 13-15 part, Acronychi apedunculata (L.) Miq. 10-14 part, Fructus Arctii 15-22 part, Flos Chrysanthemi 4-8 part, Herba Menthae 9-12
Part, Xian root 12-16 part, Caput Accipiter 1-5 part, crystal sugar 15-18 part.
2. the preparation method of the Chinese medicine preparation of anti metastasis as claimed in claim 1, it is characterised in that comprise the following steps:
(1) all crude drug are got ready clean according to institute's expense；
(2) first Rhizoma Et Radix Notopterygii carry out the soak extraction of 30min with the chloroform of 2-3 times of quality, and Radix Puerariae, Herba Lophatheri are by 2-3 times of quality
Dehydrated alcohol carry out the soak extraction of 45min, the citric acid of 2-3 times of quality of Acronychi apedunculata (L.) Miq. carries out the soak extraction of 45min, will
Extracting solution mix homogeneously after extraction is stand-by；
(3) going by respective quality 4-5 times after Fructus Arctii, Flos Chrysanthemi, Herba Menthae, Xian root, Caput Accipiter, crystal sugar being crushed to 1cm respectively
Ionized water submergence is standby；
(4) first Xian root, Caput Accipiter big fire boil rear slow fire continue to decoct 30min to leach medicinal liquid standby, obtain filtering residue；
(5) adding Flos Chrysanthemi, Herba Menthae, Fructus Arctii and crystal sugar in the filtering residue of step (4), big fire continues to decoct after boiling
Medicinal liquid is leached standby after 25min；Abandon filtering residue；
(6) the medicinal liquid mix homogeneously that the extracting solution that step (2) obtained, step (4) and (5) obtain carries out being concentrated into relative density
It is 1.05, enter spray dryer, inlet temperature controls 120～130 DEG C, and leaving air temp 120～130 DEG C obtain spray drying powder,
The Chinese medicine preparation of described anti metastasis.
The preparation method of the Chinese medicine preparation of anti metastasis the most according to claim 2, it is characterised in that: described step
(2) mass concentration of the chloroform in is 45%-65%.
The preparation method of the Chinese medicine preparation of anti metastasis the most according to claim 2, it is characterised in that: described step
(2) mass concentration of the dehydrated alcohol in is 60%-80%.
The preparation method of the Chinese medicine preparation of anti metastasis the most according to claim 2, it is characterised in that: described step
(2) mass concentration of the citric acid in is 85%-95%.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846794A (en) * | 2012-10-16 | 2013-01-02 | 李国祥 | Medicine composition for treating cancer and preparation method thereof |
| CN105213974A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | One treats lymphadenomatous Chinese medicine composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846794A (en) * | 2012-10-16 | 2013-01-02 | 李国祥 | Medicine composition for treating cancer and preparation method thereof |
| CN105213974A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | One treats lymphadenomatous Chinese medicine composition and application thereof |
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