CN106038988A - Natural plant extract for preventing and curing pneumoconiosis and preparation thereof - Google Patents
Natural plant extract for preventing and curing pneumoconiosis and preparation thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a natural plant extract for preventing and curing pneumoconiosis and preparation thereof. The natural plant extract and preparation thereof comprises the following ingredients in percentage by weight: 30-60% of rhizoma fagopyri dibotryis ethanol extract, 20-40% of rhizoma polygonati ethanol extract, 10-20% of lucid ganoderma ethanol extract. The three types of ethanol extracts have certain efficacy of preventing or treating lung diseases when used separately, have favorable compatibility when combined for use, supplement each other and have a synergistic effect, so that the natural plant extract has a better efficacy of clearing away the lung-heat and tonifying lung in comparison with a single extract or combination of any two types of extracts, is capable of obviously inhibiting lung fibrosis, improving the respiratory symptoms of pneumoconiosis patients, and has a better effect of preventing or treating pneumoconiosis; the natural plant extract contains less types of components, bulk pharmaceutical chemicals are convenient to acquire, the price is low, and the treatment cost is greatly lowered.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of natural plant extracts for preventing and treating pneumoconiosis and system thereof
Agent.
Background technology
Dust refers to be formed in process of production, and can long-time floating aerial solid particle.New at some
In material, chemical engineering industry production process, dust also can adsorb other gaseous state or liquid harmful substance, staff sucks this
After being loaded with the dust of harmful substance a bit, a series of disease can be caused.Wherein, pneumoconiosis be exactly labourer in vocational activity because of
The lung fibrosis sucking dust and occur is main disease.The silicon tuberosity that lung fibrosis is formed is irreversible.
If treating the most in time after must going up pneumoconiosis particularly pneumosilicosis, the state of an illness can gradually develop deterioration, and last patient can exhale because lungs lose
Inhale function and dead.
In order to treat pneumoconiosis, the Chinese invention patent application of Application No. 201510844469.8 disclose a kind of for
The Chinese medicine for the treatment of pneumoconiosis, this Chinese medicine includes the crude drug of following weight portion: Bulbus Lilii 24～30 parts, Bulbus Fritillariae Cirrhosae 24～30 parts, Radix Scutellariae
13～16 parts, Radix Angelicae Sinensis 14～21 parts, Folium Eriobotryae 24～30 parts, the Radix Stemonae 13～16 parts, the Radix Astragali 34～40 parts, Lignum Sappan 8～11 parts, Fu
Siberian cocklebur 12～15 parts, Rhizoma Chuanxiong 12～15 parts, Radix Notoginseng 12～15 parts, Herba Scutellariae Barbatae 14～22 parts, Fructus Forsythiae 14～22 parts, Herba Houttuyniae 24～32
Part, 14～22 parts, 10～20 parts, Radix Platycodonis 19～26 parts.
Wherein, Bulbus Lilii has effect of lung-heat clearing and detoxification；The Radix Stemonae, Bulbus Fritillariae Cirrhosae, Flos Carthami and Radix Platycodonis have effect that removing food stagnancy is regulated the flow of vital energy；Party
Ginseng has effect of convergence lung qi；The Radix Astragali has vital base and primordial QI consolidating, strengthens effect of the resistance of patient.This is used for treating pneumoconiosis
The recovery from illness that Chinese medicine is Pneumoconiosis Patients bring hope.
But at this for treating in the Chinese medicine of pneumoconiosis, the herbal species of needs causes making up the prescription extremely inconvenient more, and Radix Notoginseng,
The Radix Astragali, Flos Carthami and Radix Codonopsis are expensive, and the Chinese medicine of these costlinesses improves treatment cost.
Summary of the invention
The invention provides a kind of natural plant extracts for preventing and treating pneumoconiosis, this natural plant extracts solves
Existing pneumoconiosis treats the problem that Chinese medicinal components is various, cost is high.
A kind of natural plant extracts for preventing and treating pneumoconiosis, with weight, this natural plant extracts
Including: Rhizoma Fagopyri Dibotryis ethanol extraction 30-60%, Rhizoma Polygonati ethanol extraction 20-40%, Ganoderma ethanol extraction 10-20%.
Wherein, Rhizoma Fagopyri Dibotryis is the Chinese herbal medicine of the wide-spread a kind of medicine-food two-purpose of China's folk tradition, and tuber can be used as medicine,
Micro-cool, property is put down, sour and astringent, and bitter in the mouth has the effects such as heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea, lung moistening the kidney invigorating, wind-damp dispelling；Rhizoma Polygonati sweet in the mouth is put down,
Containing compositions such as polysaccharide, aminoacid, lymphatic temperament, starch, the cardio-pulmonary function of human body can be strengthened, slow down aging, it is used for deficiency of YIN lung
Dry, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney；Ganoderma has high medical value, and remarkable result is enhancing body
Immunity；If immune dysfunction is disorderly, various disease will be caused, such as respiratory tract infection, tumor, hepatitis, insomnia etc..Spirit
Sesame, possibly together with abundant Ganodenic acid (triterpenoid compound), Ganoderma alkaloid etc., can effectively suppress the release of histamine, alleviates and props up
Tracheal smooth muscle spasm, and have the function that bronchus Ciliated epithelium is repaired, reach lung heat clearing and support the effect of lung, relieving cough and expelling phlegm.
The ethanol extraction of these three Chinese medicine is respectively provided with certain prevention or effect for the treatment of pneumoconiosis when being used alone, and
And after being applied in combination, between Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol extraction and Ganoderma ethanol extraction, there is good joining
Complement each other between Wu Xing, and each component, there is synergism so that the natural plant extracts obtained after combination ratio is individually
The combination of a kind of extract or any two extracts more has lung heat clearing and supports lung effect, it is possible to substantially suppression pneumoconiosis fibrosis, changes
The Respiratory symptoms of kind Pneumoconiosis Patients, to the prevention of pneumoconiosis or therapeutic effect more preferably.
Meanwhile, constituent species contained by the natural plant extracts of the present invention is few, and crude drug is drawn materials conveniently, cheap, greatly
Reduce greatly the treatment cost of Pneumoconiosis Patients.
As preferably, described natural plant extracts also includes: lily bulb, Semen Sojae Preparatum, Vascular aurantii, Pericarpium Citri tangerinae, Fructus Fici, Huang
The ethanol extraction of at least one in stilbene, Radix Codonopsis or Cordyceps.
As further preferably, described natural plant extracts also includes: in lily bulb, Semen Sojae Preparatum, Vascular aurantii at least one
The ethanol extraction planted.Wherein, lily bulb has the effect moisturizing removing toxic substances；Semen Sojae Preparatum has effect of lung-heat clearing and detoxification；Vascular aurantii
The effect of preventing phlegm from forming and stopping coughing can be played.These three Chinese medicine complements each other, and with Pericarpium Citri tangerinae, Fructus Fici, the Radix Astragali, Radix Codonopsis, Cordyceps phase
Ratio, these three Chinese medicine is with Rhizoma Fagopyri Dibotryis, Rhizoma Polygonati, Ganoderma compatibility more preferably, higher with the use of the rear property of medicine.
As preferably, with weight, described natural plant extracts includes: Rhizoma Fagopyri Dibotryis ethanol extraction 30-
60%, Rhizoma Polygonati ethanol extraction 20-40%, Ganoderma ethanol extraction 10-20%, Bulbus Lilii ethanol extraction 2-3%, Semen Sojae Preparatum second
Alcohol extraction thing 1-2%, Vascular aurantii ethanol extraction 5-7%.It is demonstrated experimentally that take the product property of medicine obtained by this weight percentage
More significantly, preventive effect is obviously improved.
As further preferably, with weight, described natural plant extracts includes: Rhizoma Fagopyri Dibotryis ethanol extraction
Thing 40%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol extraction 3%, Semen Sojae Preparatum ethanol extraction
Thing 1%, Vascular aurantii ethanol extraction 6%.
Present invention also offers described for preventing and treating the preparation method of the natural plant extracts of pneumoconiosis, this preparation method
Including:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 80-100 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 50-70 DEG C, 300-by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 80-100min under the conditions of 350W, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 30-50 mesh；
(2.2) Solomonseal Rhizome is mixed, in 40-50 DEG C, 400-by weight 1:10 with the ethanol of volume fraction 80%
Ultrasonic water bath 50-70min under the conditions of 500W, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 40-60 mesh；
(3.2) REISH is mixed, in 80-100 DEG C, 250-by weight 1:15 with the ethanol of volume fraction 80%
Ultrasonic water bath 100-120min under the conditions of 300W, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii is clean, dried, grind to form the Bulbus Lilii powder that granularity is 30-40 mesh；
(4.2) described Bulbus Lilii powder is mixed, in 40-60 DEG C, 250-by weight 1:8 with the ethanol of volume fraction 60%
Ultrasonic water bath 30-40min under the conditions of 300W, filters, and takes filtrate, and rotation is steamed to dry, obtained Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol are carried
Take thing, Semen Sojae Preparatum ethanol extraction and Vascular aurantii ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.
Utilize the natural plant extracts that above-mentioned preparation method obtains, Golden Buckwheat Rhizome, Solomonseal Rhizome, REISH, hundred
The effective ingredient closed in powder, Fermented soybean and Vascular aurantii powder can be extracted efficiently so that the dirt of natural plant extracts
Pneumonopathy prevention effect is more significantly.
As further preferably, described preparation method particularly as follows:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 90 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 60 DEG C, 320W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 90min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 40 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 45 DEG C, under the conditions of 450W
Ultrasonic water bath 60min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 50 mesh；
(3.2) ethanol of REISH and volume fraction 80% is mixed by weight 1:15, in 90 DEG C, under the conditions of 275W
Ultrasonic water bath 115min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii cleaned, be dried, grind to form the Bulbus Lilii powder that granularity is 35 mesh；
(4.2) the Bulbus Lilii powder obtained is mixed, in 50 DEG C, 280W by weight 1:8 with the ethanol of volume fraction 60%
Under the conditions of ultrasonic water bath 35min, filter, take filtrate, rotation is steamed to dry, obtains Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol are carried
Take thing, Semen Sojae Preparatum ethanol extraction and Vascular aurantii ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.
It is demonstrated experimentally that extract Golden Buckwheat Rhizome, Solomonseal Rhizome, REISH, Bulbus Lilii powder, light under the conditions of constraints above
Effective ingredient purity in Semen Sojae Preparatum powder and Vascular aurantii powder is more increased, and the property of medicine is more significantly, and patient's curative effect becomes apparent from.
Present invention also offers a kind of natural plant extracts preparation for preventing and treating pneumoconiosis, this natural plant extracts
Preparation is i.e. prepared from by described natural plant extracts.
As preferably, described natural plant extracts preparation is capsule.Capsule is more convenient to carry and takes, and adapts to
Crowd is more extensive.
Present invention also offers the preparation method of a kind of described natural plant extracts preparation, this preparation method includes: use
60% ethanol dissolves described natural plant extracts, and 500:1:1 in mass ratio adds respectively in described natural plant extracts
Enter maltodextrin and beta-schardinger dextrin-, intake air temperature be 160 DEG C, temperature of outgoing air be 85 DEG C, dried material moisture little
It is spray-dried under conditions of 5%, loads capsule, obtain described natural plant extracts preparation.
In described natural plant extracts, add maltodextrin and beta-schardinger dextrin-can solve gluing in spray drying
Wall problem, improves productivity；Air inlet is both arranged on 160 DEG C so that droplet is immediately dried into granular crystals when ejection,
Also can guarantee that the effective ingredient activity do not destroyed inside product.
Compared with prior art, the invention have the benefit that
(1) in the natural plant extracts of the present invention, each component is respectively provided with certain prevention or treatment pneumoconiosis when being used alone
Sick effect, and after being applied in combination, have between Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol extraction and Ganoderma ethanol extraction
Have between good compatibility, and each component and complement each other, there is synergism so that the natural plants obtained after combination carries
Take thing there is strong effective lung heat clearing to support lung effect, it is possible to substantially suppression pneumoconiosis fibrosis, improve the respiratory system of Pneumoconiosis Patients
Symptom, to the prevention of pneumoconiosis or therapeutic effect more preferably；
(2) constituent species contained by the natural plant extracts of the present invention is few, and crude drug is drawn materials conveniently, cheap, significantly
Reduce the treatment cost of Pneumoconiosis Patients.
Detailed description of the invention
Use detailed description of the invention that technical scheme is described in further detail below.
Embodiment 1
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 50%, Rhizoma Polygonati ethanol extraction 30%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol carries
Take thing 3%, Semen Sojae Preparatum ethanol extraction 1%, Vascular aurantii ethanol extraction 6%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 80 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 50 DEG C, 300W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 80min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 30 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 40 DEG C, under the conditions of 400W
Ultrasonic water bath 50min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 40 mesh；
(3.2) ethanol of REISH and volume fraction 80% is mixed by weight 1:15, in 80 DEG C, under the conditions of 250W
Ultrasonic water bath 100min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii cleaned, be dried, grind to form the Bulbus Lilii powder that granularity is 30 mesh；
(4.2) the Bulbus Lilii powder obtained is mixed, in 40 DEG C, 250W by weight 1:8 with the ethanol of volume fraction 60%
Under the conditions of ultrasonic water bath 30min, filter, take filtrate, rotation is steamed to dry, obtains Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol are carried
Take thing, Semen Sojae Preparatum ethanol extraction and Vascular aurantii ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.
Embodiment 2
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 40%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol carries
Take thing 2.5%, Semen Sojae Preparatum ethanol extraction 1.5%, Vascular aurantii ethanol extraction 6%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 90 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 60 DEG C, 320W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 90min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 40 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 45 DEG C, under the conditions of 450W
Ultrasonic water bath 60min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 50 mesh；
(3.2) ethanol of REISH and volume fraction 80% is mixed by weight 1:15, in 90 DEG C, under the conditions of 275W
Ultrasonic water bath 115min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；(4) Bulbus Lilii ethanol extraction
Preparation:
(4.1) Bulbus Lilii cleaned, be dried, grind to form the Bulbus Lilii powder that granularity is 35 mesh；
(4.2) the Bulbus Lilii powder obtained is mixed, in 50 DEG C, 280W by weight 1:8 with the ethanol of volume fraction 60%
Under the conditions of ultrasonic water bath 35min, filter, take filtrate, rotation is steamed to dry, obtains Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol are carried
Take thing, Semen Sojae Preparatum ethanol extraction and Vascular aurantii ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.；
Embodiment 3
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 30%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 20%, Bulbus Lilii ethanol carries
Take thing 2%, Semen Sojae Preparatum ethanol extraction 2%, Vascular aurantii ethanol extraction 6%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 100 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 70 DEG C, 350W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 100min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 50 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 50 DEG C, under the conditions of 500W
Ultrasonic water bath 70min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 60 mesh；
(3.2) REISH is mixed, in 100 DEG C, 300W condition by weight 1:15 with the ethanol of volume fraction 80%
Lower ultrasonic water bath 120min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii cleaned, be dried, grind to form the Bulbus Lilii powder that granularity is 40 mesh；
(4.2) the Bulbus Lilii powder obtained is mixed, in 60 DEG C, 300W by weight 1:8 with the ethanol of volume fraction 60%
Under the conditions of ultrasonic water bath 40min, filter, take filtrate, rotation is steamed to dry, obtains Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol are carried
Take thing, Semen Sojae Preparatum ethanol extraction and Vascular aurantii ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.
Embodiment 4
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 30%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 20%, Pericarpium Citri tangerinae ethanol carries
Take thing 2%, Fructus Fici ethanol extraction 2%, Radix Astragali ethanol extraction 6%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 100 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 70 DEG C, 350W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 100min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 50 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 50 DEG C, under the conditions of 500W
Ultrasonic water bath 70min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 60 mesh；
(3.2) REISH is mixed, in 100 DEG C, 300W condition by weight 1:15 with the ethanol of volume fraction 80%
Lower ultrasonic water bath 120min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Pericarpium Citri tangerinae ethanol extraction:
(4.1) Pericarpium Citri tangerinae cleaned, be dried, grind to form the Pericarpium Citri tangerinae powder that granularity is 40 mesh；
(4.2) the Pericarpium Citri tangerinae powder obtained is mixed, in 60 DEG C, 300W by weight 1:8 with the ethanol of volume fraction 60%
Under the conditions of ultrasonic water bath 40min, filter, take filtrate, rotation is steamed to dry, obtains Pericarpium Citri tangerinae ethanol extraction；
(5) preparation of Fructus Fici ethanol extraction: identical with step (4)；
(6) preparation of Radix Astragali ethanol extraction: identical with step (4)；
(7) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Pericarpium Citri tangerinae ethanol are carried
Take thing, Fructus Fici ethanol extraction and Radix Astragali ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the sky of pneumoconiosis
So plant extract.
Embodiment 5
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 30%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 20%, Radix Codonopsis ethanol carries
Take thing 4%, Cordyceps ethanol extraction 6%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 100 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 70 DEG C, 350W bar by weight 1:4 with the ethanol that volume fraction is 85%
Ultrasonic water bath 100min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 50 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 50 DEG C, under the conditions of 500W
Ultrasonic water bath 70min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 60 mesh；
(3.2) REISH is mixed, in 100 DEG C, 300W condition by weight 1:15 with the ethanol of volume fraction 80%
Lower ultrasonic water bath 120min, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma ethanol extraction；
(4) preparation of Radix Codonopsis ethanol extraction:
(4.1) Radix Codonopsis cleaned, be dried, grind to form the Radix Codonopsis powder that granularity is 40 mesh；
(4.2) powder obtained is mixed, in 60 DEG C, 300W condition by weight 1:8 with the ethanol of volume fraction 60%
Lower ultrasonic water bath 40min, filters, and takes filtrate, and rotation is steamed to dry, obtained Radix Codonopsis ethanol extraction；
(5) preparation of Cordyceps ethanol extraction: identical with step (4)；
(6) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Radix Codonopsis ethanol are carried
Take thing and Cordyceps ethanol extraction to mix according to preset ratio, it is thus achieved that for preventing and treating the natural plant extracts of pneumoconiosis.
Embodiment 6
With weight, a kind of natural plant extracts for preventing and treating pneumoconiosis of the present embodiment, by following thing
Matter forms: Rhizoma Fagopyri Dibotryis ethanol extraction 40%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 10%, maltodextrin
10%.
Its preparation method includes:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction: same as in Example 2；
(2) preparation of Rhizoma Polygonati ethanol extraction: same as in Example 2；
(3) preparation of Ganoderma ethanol extraction: same as in Example 2；
(4) the Rhizoma Fagopyri Dibotryis ethanol extraction of acquisition, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction and maltodextrin are pressed
Mix according to preset ratio, it is thus achieved that for preventing and treating the natural plant extracts of pneumoconiosis.
Comparative example 1
With weight, this comparative example is used for preventing and treating pneumoconiosis natural plant extracts and is made up of following material:
Maltodextrin 50%, Rhizoma Polygonati ethanol extraction 30%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol extraction 3%, Semen Sojae Preparatum second
Alcohol extraction thing 1%, Vascular aurantii ethanol extraction 6%.
Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii second
The preparation method of alcohol extraction thing is with reference to embodiment 2；After having prepared, by the Rhizoma Polygonati ethanol extraction obtained, Ganoderma ethanol extraction
Thing, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii ethanol extraction mix according to preset ratio, it is thus achieved that be used for preventing
Control the natural plant extracts of pneumoconiosis.
Comparative example 2
With weight, this comparative example is used for preventing and treating pneumoconiosis natural plant extracts and is made up of following material:
Rhizoma Fagopyri Dibotryis ethanol extraction 40%, maltodextrin 40%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol extraction 2.5%, light bean
Fermented soya beans, salted or other wise ethanol extraction 1.5%, Vascular aurantii ethanol extraction 6%.
Rhizoma Fagopyri Dibotryis ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii
The preparation method of ethanol extraction is with reference to embodiment 2；After having prepared, by the Rhizoma Fagopyri Dibotryis ethanol extraction obtained, Ganoderma ethanol
Extract, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii ethanol extraction mix according to preset ratio, it is thus achieved that use
Natural plant extracts in preventing and treating pneumoconiosis.
Comparative example 3
With weight, this comparative example is used for preventing and treating pneumoconiosis natural plant extracts and is made up of following material:
Rhizoma Fagopyri Dibotryis ethanol extraction 30%, Rhizoma Polygonati ethanol extraction 40%, maltodextrin 20%, Bulbus Lilii ethanol extraction 2%, Semen Sojae Preparatum
Ethanol extraction 2%, Vascular aurantii ethanol extraction 6%.
Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol extraction, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii
The preparation method of ethanol extraction is with reference to embodiment 2；After having prepared, by the Rhizoma Fagopyri Dibotryis ethanol extraction obtained, Ganoderma ethanol
Extract, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum ethanol extraction, Vascular aurantii ethanol extraction mix according to preset ratio, it is thus achieved that use
Natural plant extracts in preventing and treating pneumoconiosis.
Embodiment 1～6, the natural plant extracts of comparative example 1～3 preparation is dissolved with 60% ethanol, and to corresponding sky
So in plant extract, 500:1:1 in mass ratio is separately added into maltodextrin and beta-schardinger dextrin-, intake air temperature be 165 DEG C,
Temperature of outgoing air is 85 DEG C, be spray-dried under conditions of dried material moisture no more than 5%, loads capsule, it is thus achieved that phase
The preventing and treating pneumoconiosis natural plant extracts preparation answered.
Test case 1
Take from Zhejiang A & F University's Vet special experimental white mouse 550.550 white mice are randomly divided into 11
Group, often group 50, numbered A, B, C, D, E, F, G, H, I, J and K, divide A, B, C, D, E, F, G, H, I and J group white mice respectively
It is not placed in the big plastic casing containing analytical pure silicon dioxide ultrafine powder dirt raising 16 weeks, wherein this silicon dioxide fineness ＜ 5 μ
Granule number more than 99%, K group white mice is placed in cleaning big plastic casing in raise 16 weeks, during raising respectively to A, B, C, D,
E, F, G, H, I group white mice correspondence nursing embodiment 1-6, the natural plant extracts preparation of comparative example 1～3, each one, one
Day twice；Simultaneously to J, K group white mice nursing placebo, each one, twice on the one.
24h after last administration, takes off white mice cervical vertebra and puts to death.Solution takes lungs and claims full weight, in every part of specimen quantitatively
Weigh a small amount of fresh lung tissue, add physiological sodium chloride and make the tissue homogenate of 2%, be used for measuring HP content (digestion method).Fixed again
Amount weighs 0.5g lung tissue and shreds rear acetone defat 3d, 105 DEG C of baking oven baking 12h, claims dry weight, conversion to help the dry weight of lung.Its
Remaining lung tissue is fixed with 10% formaldehyde, paraffin section, after HE dyeing, carries out routine pathology and checks and silicon tuberosity classification meter
Point.
Pneumosilicosis is divided into 4 grades by light microscopy checking, i.e. I level: cellularity tuberosity, based on cell component in tuberosity, with on a small quantity
Collagen fiber；Mainly be made up of dust cell, can between have a small amount of Reticulocyte, but collagen-free fiber；II level: tie for fibrocyte
Joint.III level: for cell fibrous tubercle, in tuberosity, collagen fiber increase, and cell component significantly reduces；IV level: completely by collagen
The typical silicon tuberosity that fiber is constituted, in vitreous degeneration.Silicon tuberosity point system is, each specimen is cut into slices at low power Microscopic observation
5 visuals field, often see 1 I level tuberosity meter 1 point, 1 II level tuberosity meter 1.2 points, 1 III level tuberosity meter 1.4 points, 1 IV level
Count 1.6 points, then all of tuberosity is added up to this group total score.Experiment concrete condition statistics is as follows:
Table 1 white mice suffers from pneumosilicosis situation statistical table
From table 1, compared with J group, the white mice suffering from pneumosilicosis in A-F group is mainly distributed on I level and II level, and minority is little
White mouse suffers from III level pneumosilicosis；Show that the natural plant extracts of the present invention has preferably Prevention of lung disease effect to white mice,
White mice be can effectively reduce and III level and the probability of IV level pneumosilicosis suffered from.
Wherein, although the natural plant extracts of embodiment 6 has preferably Prevention of lung disease effect to F group white mice,
But there is 11.4% white mice to suffer from III level pneumosilicosis, have 20% white mice to suffer from II level pneumosilicosis；And feed the sky of embodiment 1～5
So there is not III level pneumosilicosis in A～the E group white mice of plant extract, and the ratio suffering from II level pneumosilicosis white mice is relatively low,
Only up to 37% (embodiment 4), minimum only 14% (embodiment 2).Show lily bulb, Semen Sojae Preparatum, Vascular aurantii, Pericarpium Citri tangerinae, nothing
Flowers and fruits, the Radix Astragali, Radix Codonopsis, the addition of Cordyceps all can be effectively improved the Prevention of lung disease effect of natural plant extracts.
Further, knowable to D～the E group disease condition with A～C group white mice, with Pericarpium Citri tangerinae, Fructus Fici, the Radix Astragali, Radix Codonopsis, worm
Grass is compared, and lily bulb, Semen Sojae Preparatum, Vascular aurantii are higher to the castering action of the Prevention of lung disease effect of natural plant extracts.
Meanwhile, knowable to G～the I group disease condition with B group white mice, Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol are lacked
After extract, Ganoderma ethanol extraction, the Prevention of lung disease effect of natural plant extracts is all substantially reduced, the pneumosilicosis of white mice
Grade all promotes one-level.Wherein, after disappearance ethanol Rhizoma Fagopyri Dibotryis extract, the ratio suffering from III level pneumosilicosis white mice is promoted to
42.8%, the ratio suffering from IV level pneumosilicosis white mice is promoted to 22%；After disappearance Rhizoma Polygonati ethanol extraction, suffer from III level pneumosilicosis
The ratio of white mice is promoted to 37%, and the ratio suffering from IV level pneumosilicosis white mice is promoted to 34%；Disappearance Ganoderma ethanol extraction
After, the ratio suffering from III level pneumosilicosis white mice is promoted to 28%, and the ratio suffering from IV level pneumosilicosis white mice is promoted to 17%.This
Showing, Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction are in the natural plant extracts of the present invention
Playing vital effect, in three, the disappearance of any one all can cause being greatly reduced of Prevention of lung disease effect, and passes through
Supplement to feed and be difficult to make up this reduction, show to have between this three certain synergism, there is compound synergic each other
Effect.
Test case 2
White mice in above-mentioned J group is randomly divided into eight groups (a, b, c, d, e, f, g, h, i, j), by eight groups of ill white mice
It is respectively placed in the big plastic casing of cleaning and raises 16 weeks, during raising, feed embodiment to a～i group ill white mice correspondence respectively
1-6, the natural plant extracts preparation of comparative example 1～3, each one, twice on the one；Feed to the ill white mice of j group simultaneously
Placebo, each one, twice on the one.
Carry out routine pathology according to the method identical with test case 1 to check and silicon tuberosity classification score, then will be all
Tuberosity add up to this group total score.Experiment concrete condition statistics is as follows:
Table 2 white mice silicon tuberosity situation statistical table
From table 2, compared with g group, the white mice suffering from pneumosilicosis in a～c group is all distributed in I level and II level；Show
The natural plant extracts of the present invention has preferably pneumoconiosis therapeutic effect to white mice, it is possible to effectively treatment has been inflicted with III
Level and the ill white mice of IV level pneumosilicosis.
Wherein, although the natural plant extracts of embodiment 6 has preferably pneumoconiosis therapeutic effect to f group white mice,
But the ill white mice still having 40% is in III level pneumosilicosis, 40% ill white mice is had to be in II level pneumosilicosis；Feed embodiment
The ratio being in III level pneumosilicosis in a～the c group of the natural plant extracts of 1～3 in ill white mice is all 0%, and ill little
White mouse is in the ratio of II level pneumosilicosis and is respectively 40%, 20% and 60%；And feed the natural plant extracts of embodiment 4～5
D～e group in be in the ratio of III level pneumosilicosis in ill white mice be all 20%, and ill white mice is in II level pneumosilicosis
Ratio is respectively 40% and 60%.Show lily bulb, Semen Sojae Preparatum, Vascular aurantii, Pericarpium Citri tangerinae, Fructus Fici, the Radix Astragali, Radix Codonopsis, the adding of Cordyceps
Enter to be effectively improved the pneumoconiosis therapeutic effect of natural plant extracts, and the therapeutic effect of lily bulb, Semen Sojae Preparatum, Vascular aurantii
More preferably.
Meanwhile, knowable to g～the i group ill white mice contrast situation with the ill white mice of a～c group, Rhizoma Fagopyri Dibotryis second is lacked
After alcohol extraction thing, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, the pneumoconiosis therapeutic effect of natural plant extracts is the most significantly
Reduce.Wherein, in the ill white mice of g group feeding the natural plant extracts preparation without Rhizoma Fagopyri Dibotryis ethanol extraction, still
Have 20% to be in IV level pneumosilicosis, 60% be in III level pneumosilicosis；Feeding without Rhizoma Polygonati ethanol extraction, carrying without Ganoderma ethanol
Take in the h group of thing, the ill white mice of i group, still have 20% to be in IV level pneumosilicosis, 40% be in III level pneumosilicosis.This shows, Jin Qiao
Wheat ethanol extraction, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction play to pass in the natural plant extracts of the present invention
Important effect, in three, the disappearance of any one all can cause being greatly reduced of pneumoconiosis therapeutic effect, and feeds by supplementing
It is difficult to make up this reduction, shows to have between this three certain synergism, there is compound synergic effect each other.
The test result of test case 1 and test case 2 shows: the natural plant extracts of the present invention is treating and preventing pneumoconiosis
Sick aspect is respectively provided with significant effect, it is possible to substantially suppression pneumoconiosis fibrosis, improves the respiratory system disease of pneumoconiosis disease mice
Shape, wherein with treatment and prevention best results to pneumoconiosis of the natural plant extracts of embodiment 2.
Claims (10)
1. one kind for preventing and treating the natural plant extracts of pneumoconiosis, it is characterised in that with weight, including: gold
Semen Fagopyri Esculenti ethanol extraction 30-60%, Rhizoma Polygonati ethanol extraction 20-40%, Ganoderma ethanol extraction 10-20%.
Natural plant extracts for preventing and treating pneumoconiosis the most according to claim 1, it is characterised in that also include: hundred
Close the ethanol extraction of at least one in bulb, Semen Sojae Preparatum, Vascular aurantii, Pericarpium Citri tangerinae, Fructus Fici, the Radix Astragali, Radix Codonopsis or Cordyceps.
Natural plant extracts for preventing and treating pneumoconiosis the most according to claim 2, it is characterised in that also include: hundred
Close the ethanol extraction of at least one in bulb, Semen Sojae Preparatum, Vascular aurantii.
4. according to the arbitrary described natural plant extracts for preventing and treating pneumoconiosis of claim 1-3, it is characterised in that with weight
Amount percentage composition meter, including:
Rhizoma Fagopyri Dibotryis ethanol extraction 30-60%, Rhizoma Polygonati ethanol extraction 20-40%, Ganoderma ethanol extraction 10-20%, Bulbus Lilii
Ethanol extraction 2-3%, Semen Sojae Preparatum ethanol extraction 1-2%, Vascular aurantii ethanol extraction 5-7%.
Natural plant extracts for preventing and treating pneumoconiosis the most according to claim 4, it is characterised in that with weight percent
Content meter, including:
Rhizoma Fagopyri Dibotryis ethanol extraction 40%, Rhizoma Polygonati ethanol extraction 40%, Ganoderma ethanol extraction 10%, Bulbus Lilii ethanol extraction
3%, Semen Sojae Preparatum ethanol extraction 2%, Vascular aurantii ethanol extraction 6%.
The preparation method of the natural plant extracts for preventing and treating pneumoconiosis the most according to claim 4, it is characterised in that
Including:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 80-100 mesh；
(1.2) Golden Buckwheat Rhizome is mixed, in 50-70 DEG C, 300-350W by weight 1:4 with the ethanol that volume fraction is 85%
Under the conditions of ultrasonic water bath 80-100min, filter, take filtrate, rotation is steamed to dry, obtains Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 30-50 mesh；
(2.2) Solomonseal Rhizome is mixed, in 40-50 DEG C, 400-500W bar by weight 1:10 with the ethanol of volume fraction 80%
Ultrasonic water bath 50-70min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 40-60 mesh；
(3.2) REISH is mixed, in 80-100 DEG C, 250-300W bar by weight 1:15 with the ethanol of volume fraction 80%
Ultrasonic water bath 100-120min under part, filters, and takes filtrate, and rotation is steamed to dry, obtained Rhizoma Polygonati Ganoderma extract；
(4) prepared by Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii is clean, dried, grind to form the Bulbus Lilii powder that granularity is 30-40 mesh；
(4.2) Bulbus Lilii powder is mixed, in 40-60 DEG C, 250-300W condition by weight 1:8 with the ethanol of volume fraction 60%
Lower ultrasonic water bath 30-40min, filters, and takes filtrate, and rotation is steamed to dry, obtained Bulbus Lilii ethanol extraction；
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4)；
(7) by Rhizoma Fagopyri Dibotryis ethanol extraction, Rhizoma Polygonati ethanol extraction, Ganoderma ethanol extraction, Bulbus Lilii ethanol extraction, Semen Sojae Preparatum
Ethanol extraction and Vascular aurantii ethanol extraction mix according to preset ratio, it is thus achieved that the described natural plants for preventing and treating pneumoconiosis carries
Take thing.
The preparation method of the natural plant extracts for preventing and treating pneumoconiosis the most according to claim 6, it is characterised in that
Including:
(1) preparation of Rhizoma Fagopyri Dibotryis ethanol extraction:
(1.1) herb of Rhizoma Fagopyri Dibotryis is clean, dried, grind to form the Golden Buckwheat Rhizome that granularity is 90 mesh；
(1.2) Golden Buckwheat Rhizome and the ethanol that volume fraction is 85% are mixed by weight 1:4, in 60 DEG C, under the conditions of 320W
Ultrasonic water bath 90min, filters, takes filtrate, obtain Rhizoma Fagopyri Dibotryis ethanol extraction；
(2) preparation of Rhizoma Polygonati ethanol extraction:
(2.1) Rhizoma Polygonati is clean, dried, grind to form the Solomonseal Rhizome that granularity is 40 mesh；
(2.2) ethanol of Solomonseal Rhizome and volume fraction 80% is mixed by weight 1:10, in 45 DEG C, under the conditions of 450W ultrasonic
Water-bath 60min, filters, takes filtrate, obtain Rhizoma Polygonati ethanol extraction；
(3) preparation of Ganoderma ethanol extraction:
(3.1) Ganoderma is clean, dried, grind to form the REISH that granularity is 50 mesh；
(3.2) ethanol of REISH and volume fraction 80% is mixed by weight 1:15, in 90 DEG C, under the conditions of 275W ultrasonic
Water-bath 115min, filters, takes filtrate, obtain Rhizoma Polygonati Ganoderma extract；
(4) preparation of Bulbus Lilii ethanol extraction:
(4.1) Bulbus Lilii is clean, dried, grind to form the Bulbus Lilii powder that granularity is 35 mesh；
(4.2) ethanol of Bulbus Lilii powder and volume fraction 60% is mixed by weight 1:8, in 50 DEG C, under the conditions of 280W ultrasonic
Water-bath 35min, filters, takes filtrate, obtain Bulbus Lilii ethanol extraction.
(5) preparation of Semen Sojae Preparatum ethanol extraction: identical with step (4)；
(6) preparation of Vascular aurantii ethanol extraction: identical with step (4).
8. the natural plant extracts preparation being used for preventing and treating pneumoconiosis, it is characterised in that by institute as arbitrary in claim 1-5
The natural plant extracts of the preventing and treating pneumoconiosis stated is prepared from.
Natural plant extracts preparation for preventing and treating pneumoconiosis the most according to claim 8, it is characterised in that for capsule
Agent.
The preparation method of the natural plant extracts preparation for preventing and treating pneumoconiosis the most according to claim 8 or claim 9, its
It is characterised by, including:
Dissolve natural plant extracts as described in claim 1-5 is arbitrary with ethanol, and press in described natural plant extracts
Mass ratio 500:1:1 is separately added into maltodextrin and beta-schardinger dextrin-, intake air temperature be 160 DEG C, temperature of outgoing air be 85 DEG C, dry
It is spray-dried under conditions of dry rear material moisture no more than 5%, loads capsule, obtain described for preventing and treating pneumoconiosis
Natural plant extracts preparation.
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| CN111228374A (en) * | 2020-03-31 | 2020-06-05 | 山西纳安健康科技有限公司 | Antiviral preparation prepared based on moutan bark and preparation method thereof |
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