CN102048835A - Nano golden buckwheat rhizome dispersible tablets and preparation method thereof - Google Patents
Nano golden buckwheat rhizome dispersible tablets and preparation method thereof Download PDFInfo
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- CN102048835A CN102048835A CN2010106157183A CN201010615718A CN102048835A CN 102048835 A CN102048835 A CN 102048835A CN 2010106157183 A CN2010106157183 A CN 2010106157183A CN 201010615718 A CN201010615718 A CN 201010615718A CN 102048835 A CN102048835 A CN 102048835A
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- fagopyri esculenti
- semen fagopyri
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Abstract
The invention discloses a traditional Chinese medicine for treating lung abscess, measles pneumonia and peritonsillar abscess and a preparation method thereof. The preparation method comprises the following steps of: taking 1500g of golden buckwheat rhizome, ultrasonically extracting, filtering, decompressing, concentrating, ultrasonically jetting, spraying and drying; and adding a pharmaceutically acceptable excipient to prepare nano golden buckwheat rhizome dispersible tablets. The invention has the advantages of simple process, strong maneuverability, extraction integrity of medicine active ingredients, high product yield, bioavailability and disintegration speed, good absorption effect and stable quality.
Description
One technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of treatment lung abscess, measles pneumonia, nanometer gold Semen Fagopyri Esculenti dispersible tablet of peritonsillar abscess and preparation method thereof.
Two background technologies
Rhizoma Fagopyri Dibotryis sheet heat-clearing and toxic substances removing, the evacuation of pus blood stasis dispelling, expelling phlegm for arresting cough is relievingd asthma, be used for the treatment of symptoms such as acute lung abscess, acute and chronic tracheitis, the type of panting chronic tracheitis, bronchial asthma and bacillary dysentery, but have deficiencies such as active ingredient extracts not exclusively, product content is low, bioavailability is low, taking dose is big, disintegration rate is slow.
Three summary of the invention
For overcoming above-mentioned deficiency, the purpose of this invention is to provide that a kind of active ingredient extracts fully, product content is high, bioavailability is high, taking dose is little, disintegration rate is fast, stay-in-grade nanometer gold Semen Fagopyri Esculenti dispersible tablet and preparation method thereof.
Nanometer gold Semen Fagopyri Esculenti dispersible tablet prepares by following method:
With Rhizoma Fagopyri Dibotryis 1500g, 40-60 ℃ supersound extraction 1-5 hour, with extracting liquid filtering, 30-50 ℃ concentrating under reduced pressure 5-60 hour, decompressed concentrate is placed spray drying tower, adopt the supersonic jet technology, at 30-60 ℃, under the 0.01-0.04MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is the 360-990 meter per second, adopts the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, gets nanometer gold Semen Fagopyri Esculenti extract 60-170g, crospolyvinylpyrrolidone 4-12g, cross-linking sodium carboxymethyl cellulose 8-21g, hyprolose 8-21g, carboxymethylstach sodium 5-15g, micropowder silica gel 14-0g, microcrystalline Cellulose 18-54g, calcium sulfate 27-81g, sodium chloride 18-54g, citric acid 1-3g, aspartame 1-3g adds hyprolose 6-20g, and magnesium stearate 1-3g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
The Chinese crude drug source that above-mentioned embodiment is mentioned is as follows:
Rhizoma Fagopyri Dibotryis: be the dry rhizome of polygonaceae plant Rhizoma Fagopyri Dibotryis.Have heat-clearing and toxic substances removing, the effect of evacuation of pus blood stasis dispelling is used for lung abscess, measles pneumonia, diseases such as peritonsillar abscess.
The used crude drug of nanometer gold Semen Fagopyri Esculenti dispersible tablet all can be bought from common pharmacy and obtain, and its specification meets national medical standard.
Four specific embodiment
The following example only is used to illustrate the present invention, rather than limits the present invention by any way.
Specific embodiments of the invention 1
Depletion Semen Fagopyri Esculenti 1500g, 40 ℃ of supersound extraction 1 hour, with extracting liquid filtering, 30 ℃ of concentrating under reduced pressure 5 hours, decompressed concentrate is placed spray drying tower, adopt the supersonic jet technology, at 30 ℃, under the 0.01MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 360 meter per seconds, adopts the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, gets nanometer gold Semen Fagopyri Esculenti extract 60g, crospolyvinylpyrrolidone 4g, cross-linking sodium carboxymethyl cellulose 8g, hyprolose 8g, carboxymethylstach sodium 5g, micropowder silica gel 14g, microcrystalline Cellulose 18g, calcium sulfate 27g, sodium chloride 18g, citric acid 1g, aspartame 1g adds hyprolose 6g, and magnesium stearate 1g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
Specific embodiments of the invention 2
Depletion Semen Fagopyri Esculenti 1500g, 60 ℃ of supersound extraction 5 hours, with extracting liquid filtering, 50 ℃ of concentrating under reduced pressure 60 hours, decompressed concentrate is placed spray drying tower, adopt the supersonic jet technology, at 60 ℃, under the 0.04MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 990 meter per seconds, adopts the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, gets nanometer gold Semen Fagopyri Esculenti extract 170g, crospolyvinylpyrrolidone 12g, cross-linking sodium carboxymethyl cellulose 21g, hyprolose 21g, carboxymethylstach sodium 15g, micropowder silica gel 40g, microcrystalline Cellulose 54g, calcium sulfate 81g, sodium chloride 54g, citric acid 3g, aspartame 3g adds hyprolose 20g, and magnesium stearate 3g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
The most preferred specific embodiment 3 of the present invention
Depletion Semen Fagopyri Esculenti 1500g, 50 ℃ of supersound extraction 3.5 hours, with extracting liquid filtering, 40 ℃ of concentrating under reduced pressure 35 hours, decompressed concentrate is placed spray drying tower, adopt the supersonic jet technology, at 45 ℃, under the 0.03MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 660 meter per seconds, adopts the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, gets nanometer gold Semen Fagopyri Esculenti extract 110g, crospolyvinylpyrrolidone 8g, cross-linking sodium carboxymethyl cellulose 15g, hyprolose 15g, carboxymethylstach sodium 10g, micropowder silica gel 27g, microcrystalline Cellulose 36g, calcium sulfate 54g, sodium chloride 36g, citric acid 2g, aspartame 2g adds hyprolose 13g, and magnesium stearate 2g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
(1) method of inspection of nanometer gold Semen Fagopyri Esculenti dispersible tablet embodiment:
[discriminating] gets this product 3.6g, and porphyrize adds ethanol 20ml, and reflux 30 minutes is put coldly, filters, and filtrate is concentrated into 5ml, as need testing solution.Depletion Semen Fagopyri Esculenti control medicinal material 3g shines medical material solution in pairs with legal system in addition, according to thin layer chromatography (appendix VI B) test, drawing each 2 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developing solvent with ethyl acetate-methanol-water (5: 1.5: 0.5), launch, take out, dry, spray is with ferric chloride-iron potassuim cyanide test liquid, about 5 minutes of 105 ℃ of bakings, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
The preparation precision of [assay] reference substance solution takes by weighing the control substance of Rutin 10mg of 120 ℃ of drying under reduced pressure to constant weight, put in the 100ml measuring bottle, add ethanol dilution to scale, shake up, the accurate 10ml that draws puts in the 25ml measuring bottle, adds ethanol dilution to scale, shake up, promptly get (containing anhydrous rutin 40 μ g among every 1ml).
Accurate reference substance solution 1.0,2.0,3.0,5.0, the 6.0ml of drawing of the preparation of standard curve puts respectively in the 10ml measuring bottle, adds acetic acid-sodium-acetate buffer (pH4.5) 1ml and 0.1mol/L aluminum trichloride solution 1ml, mixing, add ethanol dilution to scale, shake up, placed 15 minutes, do blank with reagent corresponding, according to spectrophotography (appendix V B) test, measure trap at the wavelength place of 270nm, be vertical coordinate with the trap, concentration is abscissa, the drawing standard curve.
Algoscopy is got this product 3g, and accurate the title decides, porphyrize, and precision takes by weighing about 1g, put in the flask, the accurate ethanol 20ml that adds weighs reflux 1 hour, put coldly, the replenish lost amount of alcohol is filtered, and discards filtrate just, precision is measured subsequent filtrate 10ml, and water bath method, residue add water 5ml dissolving, and aqueous solution adds to the polyamide column (3g that has handled well, φ 1 * 12cm, wet method dress post) in, water 80ml eluting discards water elution liquid, reuse ethanol 100ml eluting is collected eluent, puts evaporate to dryness in the water-bath.Residue adds ethanol and dissolves in right amount, quantitatively moves in the 10ml measuring bottle, adds ethanol dilution to scale, shakes up.Precision is measured 1ml, and the method under the sighting target directrix curve preparation from " adding acetic acid-sodium acetate buffer solution (pH4.5) 1ml ", is measured trap in accordance with the law, reads the weight of rutin the need testing solution from standard curve, calculates, promptly.
Every of this product contains total flavones with rutin (C
27H
30O
16) meter, must not be less than 0.6mg.
(2) nanometer gold Semen Fagopyri Esculenti dispersible tablet treatment lung abscess, measles pneumonia, the test of peritonsillar abscess clinical observation on the therapeutic effect
1. physical data
Statistics outpatient service and inpatient accept lung abscess altogether for medical treatment, measles pneumonia, and peritonsillar abscess patient 210 examples, the patient all has lung abscess in various degree, measles pneumonia, symptoms such as peritonsillar abscess.Wherein 26～78 years old age, 51 years old mean age, adopting the Rhizoma Fagopyri Dibotryis sheet is matched group.
2. efficacy assessment standard
Cure: clinical symptom disappearance, lung abscess, measles pneumonia, peritonsillar abscess disappears.
Produce effects: clinical symptoms disappears substantially, lung abscess, and measles pneumonia, peritonsillar abscess has significant improvement.
Effectively: clinical symptoms takes a turn for the better, lung abscess, and measles pneumonia takes a turn for the better, and peritonsillar abscess has improvement to a certain degree.
Invalid: clinical symptoms does not have improvement, lung abscess, and measles pneumonia, peritonsillar abscess does not have improvement.
3. clinical observation result
The treatment lung abscess, measles pneumonia, peritonsillar abscess patient's clinical observation on the therapeutic effect comparative test result
Above-mentioned clinical observation on the therapeutic effect result shows, the nanometer gold Semen Fagopyri Esculenti dispersible tablet of the present invention's preparation is at the treatment lung abscess, measles pneumonia, during symptoms such as peritonsillar abscess, can more effectively improve patient's lung abscess under the same conditions with respect to the Rhizoma Fagopyri Dibotryis sheet, measles pneumonia, symptoms such as peritonsillar abscess.
(3) viewing test of nanometer gold Semen Fagopyri Esculenti dispersible tablet and Rhizoma Fagopyri Dibotryis sheet rutin content, disintegration time, dose
The above results shows, the nanometer gold Semen Fagopyri Esculenti dispersible tablet of the present invention's preparation is at the treatment lung abscess, measles pneumonia during the peritonsillar abscess symptom, has remarkable advantages such as active component extracts fully, content is high, taking dose is little, disintegration rate is fast with respect to the Rhizoma Fagopyri Dibotryis sheet.
Claims (2)
1. treat lung abscess for one kind, measles pneumonia, the Chinese medicine of peritonsillar abscess, it is characterized in that depletion Semen Fagopyri Esculenti 1500g, 40-60 ℃ supersound extraction 1-5 hour, filter, 30-50 ℃ concentrating under reduced pressure 5-60 hour, decompressed concentrate is placed spray drying tower, at 30-60 ℃, under the 0.01-0.04MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is the 360-990 meter per second, adopts the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, gets nanometer gold Semen Fagopyri Esculenti extract 60-170g, crospolyvinylpyrrolidone 4-12g, cross-linking sodium carboxymethyl cellulose 8-21g, hyprolose 8-21g, carboxymethylstach sodium 5-15g, micropowder silica gel 14-40g, microcrystalline Cellulose 18-54g, calcium sulfate 27-81g, sodium chloride 18-54g, citric acid 1-3g, aspartame 1-3g adds hyprolose 6-20g, and magnesium stearate 1-3g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
2. according to the preparation method of the described medicine of claim 1, it is characterized in that depletion Semen Fagopyri Esculenti 1500g, 50 ℃ of supersound extraction 3.5 hours, with extracting liquid filtering, 40 ℃ of concentrating under reduced pressure 35 hours place spray drying tower with decompressed concentrate, adopt the supersonic jet technology, at 45 ℃, 0.03MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 660 meter per seconds, adopt the impact grinding of high energy nanometer that the extract extract powder is broken into (fully by 6-18 ten thousand orders) below 300 nanometers, get nanometer gold Semen Fagopyri Esculenti extract 110g, crospolyvinylpyrrolidone 8g, cross-linking sodium carboxymethyl cellulose 15g, hyprolose 15g, carboxymethylstach sodium 10g, micropowder silica gel 27g, microcrystalline Cellulose 36g, calcium sulfate 54g, sodium chloride 36g, citric acid 2g, aspartame 2g, add hyprolose 13g, magnesium stearate 2g makes nanometer gold Semen Fagopyri Esculenti dispersible tablet.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102664052A (en) * | 2012-05-18 | 2012-09-12 | 四川大学 | Method for treating radioactive pollutant in water body by using biological adsorbent made of nano mushroom |
| CN102674497A (en) * | 2012-05-18 | 2012-09-19 | 四川大学 | Method for remediating azo dye pollution in water body by utilizing nano mushroom fungus biological adsorbent |
| CN106038988A (en) * | 2016-06-21 | 2016-10-26 | 浙江农林大学 | Natural plant extract for preventing and curing pneumoconiosis and preparation thereof |
-
2010
- 2010-12-20 CN CN2010106157183A patent/CN102048835A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102664052A (en) * | 2012-05-18 | 2012-09-12 | 四川大学 | Method for treating radioactive pollutant in water body by using biological adsorbent made of nano mushroom |
| CN102674497A (en) * | 2012-05-18 | 2012-09-19 | 四川大学 | Method for remediating azo dye pollution in water body by utilizing nano mushroom fungus biological adsorbent |
| CN106038988A (en) * | 2016-06-21 | 2016-10-26 | 浙江农林大学 | Natural plant extract for preventing and curing pneumoconiosis and preparation thereof |
| CN106038988B (en) * | 2016-06-21 | 2019-11-26 | 山西纳安健康科技有限公司 | It is a kind of for preventing and treating the natural plant extracts and its preparation of pneumoconiosis |
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Application publication date: 20110511 |