CN106038908A - Traditional Chinese medicinal preparation for treating cerebral concussion - Google Patents
Traditional Chinese medicinal preparation for treating cerebral concussion Download PDFInfo
- Publication number
- CN106038908A CN106038908A CN201610584074.3A CN201610584074A CN106038908A CN 106038908 A CN106038908 A CN 106038908A CN 201610584074 A CN201610584074 A CN 201610584074A CN 106038908 A CN106038908 A CN 106038908A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- group
- cerebral concussion
- chinese medicinal
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Abstract
The invention discloses a traditional Chinese medicinal preparation for treating cerebral concussion, and belongs to the technical field of traditional Chinese medicine. In years of clinic treatment practice, the inventor, aiming at the pathogeny of the cerebral concussion and according to the theory of symptom differentiation in traditional Chinese medicine, decocts traditional Chinese medicinal materials with the effect of regulating vital energy, promoting blood circulation, eliminating phlegm and dredging intestines with water to obtain a decoction. The traditional Chinese medicinal materials include angiopteris offiacinalis, inula salsoloides, cephalanthus occidentalis, galium aparine, helicteres isora, cyperus difformis and cornus officinalis. Clinical tests show that total effective rate reaches 100%, obviously better as compared with that of control groups, and side effects are avoided. Especially, the traditional Chinese medicinal preparation has good curative effect on hypertensives.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating cerebral concussion.
Background technology
Cerebral concussion sequela is because extraneous violence is hit, or falls from height, or falls to flutter etc. and make head injuries, brain stem netted
Structure function reduces, and affects spinal function, occur the syndrome of consciousness, muscular tension, cranial reflex reduction as.Cerebral concussion sequela
Belong to the traditional Chinese medical science " have a headache ", " dizziness ", the category such as " insomnia ".Meridians are stopped up resistance and are then had a headache, and meridians are jammed, the turbid retardance of expectorant, upset clear sun
Then dizziness or nausea and vomiting, wound is frightened, cardiopalmus then occurs in the trauma mind, insomnia, easily frightened, hypomnesis.At present, to treatment
Cerebral concussion lacks active drug, and the shortcoming of Western medicine is that action target spot is single, toxic side effect, treats the most thorough；And the traditional Chinese medical science exists
Treatment cerebral concussion aspect but has obvious advantage, dialectical can treat according to the cause of disease, not only good effect, and has no side effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating cerebral concussion.Primary disease be due to head trauma after, QI and blood is inverse
Disorderly, multiple abscess due to blood stasis is raw in brain, phlegm-damp, hinder in clear key be its main pathogenesis；Treatment crucial preferably vital energy regualting and blood circulation-promoting, eliminating phlegm catharsis.
It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment cerebral concussion is by following heavy
The Chinese herbal medicine of amount part is made: Rhizoma Angiopteridis Officinalis 80-90 part, Herba Inulae Salsoloidis 10-16 part, Radix Cephalanthi Occidentalis 120-140 part, Herba Galii Teneri 12-20
Part, Radix Helicteris Isorae 20-30 part, Herba Cyperi Difformis 80-90 part, Fructus Corni 10-16 part.
Preferred: Rhizoma Angiopteridis Officinalis 85 parts, Herba Inulae Salsoloidis 13 parts, Radix Cephalanthi Occidentalis 130 parts, Herba Galii Teneri 16 parts, Radix Helicteris Isorae 25 parts, different
Type dried tuber 85 parts, Fructus Corni 13 parts.
Preparation method: traditionally make decoction.
Fang Zhong: Rhizoma Angiopteridis Officinalis tranquilizing mind, the meridian dredging；Herba Inulae Salsoloidis clearing away heat and promoting diuresis, removing toxic substances；Radix Cephalanthi Occidentalis clearing away heat and eliminating dampness, dissipating blood stasis
Detumescence；Herba Galii Teneri clearing away damp-heat, dissipating blood stasis, subduing swelling and detoxicating；Radix Helicteris Isorae promoting the circulation of QI to relieve pain；Herba Cyperi Difformis promoting flow of QI and blood, treating stranguria, diuresis；
Fructus Corni has invigorating the liver and kidney, arresting seminal emission gas, solid collapse.
Detailed description of the invention
Embodiment one: weigh Rhizoma Angiopteridis Officinalis 80g, Herba Inulae Salsoloidis 10g, Radix Cephalanthi Occidentalis 120g, Herba Galii Teneri 12g, Radix Helicteris Isorae
20g, Herba Cyperi Difformis 80g, Fructus Corni 10g, traditionally makes decoction.
Embodiment two: weigh Rhizoma Angiopteridis Officinalis 85g, Herba Inulae Salsoloidis 13g, Radix Cephalanthi Occidentalis 130g, Herba Galii Teneri 16g, Radix Helicteris Isorae
25g, Herba Cyperi Difformis 85g, Fructus Corni 13g, traditionally makes decoction.
Embodiment three: weigh Rhizoma Angiopteridis Officinalis 90g, Herba Inulae Salsoloidis 16g, Radix Cephalanthi Occidentalis 140g, Herba Galii Teneri 20g, Radix Helicteris Isorae
30g, Herba Cyperi Difformis 90g, Fructus Corni 16g, traditionally makes decoction.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (200 ± 30) g, as chronic toxicity；
The female white mice in cleaning grade health Kunming 30, weight (20 ± 4) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (23 ± 3) DEG C, humidity (48 ± 10) %, natural lighting.
2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming
Female little from Mus 30, it is randomly divided into 2 groups, Chinese drug-treated group and each 15 of blank group.Chinese drug-treated group is administered orally 10g/d by adult normal
(being equivalent to crude drug 180g) is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Being administered volume is 1mL/20g weight, little
Mus dosage is equivalent to crude drug amount 1.113g.Blank group is given 1mL/20g weight 0.9% sodium chloride injection and is gavaged.
3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into four groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 10.Normal group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little,
In, heavy dose of group be the 5 of adult normal consumption, 15,50 times, i.e. 0.17g, 0.51g, 1.70g.It is gastric infusion.Every day 1
Secondary, experimental period is 3 months.
4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, gloss
Normally, social behavior, reaction are all normal, ingest, drain normally.Manually put to death dissection after 7d, observe its heart, liver, spleen,
Lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dye in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group internal organs table
Face is smooth, and in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, compares with blank group
No significant difference (P ＞ 0.05).The present invention is treated the Chinese medicine preparation of cerebral concussion by result of calculation display white mice
Big tolerance multiple is 220 times of adult.
5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color,
Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
Increase (P ＜ 0.05) before the experiment of weight the most relatively this group after four groups of rat experiments, but after four groups of experiments, weight comparing difference is equal
Not statistically significant (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ system after four groups of rat experiments
The number equal not statistically significant of comparing difference (P ＞ 0.05).At four groups of rats, after death important organ row staining pathologic section checks, HE
Dyeing.In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, and just
Often matched group comparing difference not statistically significant (P ＞ 0.05).
Above toxicity test shows, the Chinese medicine preparation of the treatment cerebral concussion of the present invention has no toxic reaction after being administered.
Clinical data
1, case selection: as the Chinese medicine preparation for the treatment of cerebral concussion, select cerebral concussion patients 200 example made a definite diagnosis, Qi Zhongnan
Property 95 examples, women 105 example, age 33-65 year, 42 years old mean age, patient know the inside story and voluntarily on the basis of, we are by patient
It is divided into 9 groups；Only take Rhizoma Angiopteridis Officinalis single medicinal material group to be A group, only take Herba Inulae Salsoloidis single medicinal material group and be B group, only take Radix Cephalanthi Occidentalis
Single medicinal material group is C group, only take Herba Galii Teneri single medicinal material group is D group, only takes Radix Helicteris Isorae single medicinal material group and be E group, only take abnormal shape
Dried tuber single medicinal material group is F group, only takes Fructus Corni single medicinal material group for for G group, and each single medicinal material group patient is respectively 20 examples, takes this
The treatment group patient of invention preparation is 30 examples, and matched group is 30 examples.
Each group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection: treatment group takes the Chinese medicine preparation made by embodiment of the present invention two, each single medicinal material group is taken
With treatment group same concentrations same amount of single medicinal material preparation；Respectively group every day 1 dose, a point morning and evening takes for 2 times, within 8 days, is 1 course for the treatment of, even
Continue and take 2-3 the course for the treatment of；Matched group takes ibuprofen, usual amounts of being grown up: oral, a 0.2-0.4g, every 4-6 hour 1 time；Become
People's medication maximum limitation generally 2.4g every day.
3, efficacy determination is cured: headache, dizziness, Nausea and vomiting, the symptom such as vexed are wholly absent, physical recovery health；Aobvious
Effect: headache, dizziness, Nausea and vomiting, the symptom such as vexed are clearly better, and health gradually recovers；It is effective: subjective symptoms has taken a turn for the better,
Headache, insomnia after even Animando or overwork；Invalid: by symptom after treatment without alleviating or increasing the weight of.
4, result: after treating three courses for the treatment of, comparison therapy result.
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 15 | 7 | 8 | 0 | 100.0 |
| Matched group | 30 | 9 | 12 | 4 | 5 | 66.7 |
| A group | 20 | 0 | 2 | 1 | 17 | 17.6 |
| B group | 20 | 0 | 2 | 3 | 15 | 33.3 |
| C group | 20 | 0 | 1 | 2 | 17 | 17.6 |
| D group | 20 | 0 | 1 | 1 | 18 | 11.1 |
| E group | 20 | 0 | 3 | 3 | 14 | 42.8 |
| F group | 20 | 1 | 1 | 3 | 15 | 33.3 |
| G group | 20 | 0 | 0 | 1 | 19 | 5.3 |
Result above shows, the total effective rate for the treatment of group is apparently higher than matched group, also above the total effective rate of each single medicinal material,
The generation the most without any side effects for the treatment of group.Through inspection 5-methylol-2-furancarboxylic acid in treatment group patients serum
Content organizes superposition sum far above other；It is the most collaborative between medicine and human body and medicine work through analyzing the appearance of this compound
Result.It comes from each crude drug common metabolic and produces, and this compound has stronger defying age, improves hemorheology and live
Property, microcirculation can be improved.This composition maintains the high concentration of 11h in vivo, is one of important compound treating this disease.
In the patient of above treatment, treatment group has 3 example patient's readmes, and not only cerebral concussion has obtained effective treatment, and
And the hypertension suffered from tends to normal the most therewith, after obtaining this message, we are immediately to suffering from the 50 of hypertension in various degree
Example patient treat, and curative effect judging standard is as follows:
(1), effective: 1. diastolic pressure declines ＞ 10mmHg, and reaches normal range；Though 2. diastolic pressure do not drop to normally
Decline 15mmHg or above person.Above two, reach its one and be effective.
(2) effective: 1. diastolic pressure declines ＜ 10mmHg, but has reached normal range；2. 5-is declined before diastolic pressure is relatively treated
14mmHg, but not up to normal range；3. ＞ 20mmHg is declined before shrinking pressure relatively treatment.Above three, possess one of which person,
It is effectively.
(3) invalid: not up in effective standard any one person be invalid.
Its therapeutic outcome such as following table.
| Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| 50 | 31 | 19 | 0 | 100 |
As known from the above, it is evident in efficacy that the Chinese medicine preparation of the present invention not only treats cerebral concussion, more the good news is hypertension
There are good therapeutic effect, clinic popularization and application.
Model case
Wang, man, 40 years old, builder, people from Linyi, Shandong.Patient was once kicked to the head by wooden stick, after going into a coma 10 minutes certainly
Row is clear-headed, self-induction headache after waking up, dizzy, feel sick, be diagnosed as light concussion.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention,
Symptom substantially alleviates, and after continuing to take 1 course for the treatment of, physical recovery is normal.Follow up a case by regular visits to not recur so far.
Liu, female, 32 years old, civil servant, people from Linyi, Shandong.Patient cycles and falls into severe injury, with cerebral concussion and fracture, brains
Do not regain consciousness.The symptoms such as headache, dizziness, Nausea and vomiting, poor memory, constipation are still had after hospitalization.Take Chinese medicine preparation of the present invention
After 1 course for the treatment of, symptom substantially alleviates, and after continuing to take 2 courses for the treatment of, health is fully recovered, sanity.
Claims (2)
1. the Chinese medicine preparation treating cerebral concussion, it is characterised in that the Chinese medicine preparation of this treatment cerebral concussion is by following weight portion
Chinese herbal medicine make: Rhizoma Angiopteridis Officinalis 80-90 part, Herba Inulae Salsoloidis 10-16 part, Radix Cephalanthi Occidentalis 120-140 part, Herba Galii Teneri 12-20 part, fire
Rope fiber crops 20-30 part, Herba Cyperi Difformis 80-90 part, Fructus Corni 10-16 part.
A kind of Chinese medicine preparation treating cerebral concussion, it is characterised in that the Chinese medicine of this treatment cerebral concussion
Preparation is made up of the Chinese herbal medicine of following weight portion: Rhizoma Angiopteridis Officinalis 85 parts, Herba Inulae Salsoloidis 13 parts, Radix Cephalanthi Occidentalis 130 parts, Herba Galii Teneri 16
Part, Radix Helicteris Isorae 25 parts, Herba Cyperi Difformis 85 parts, Fructus Corni 13 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610584074.3A CN106038908A (en) | 2016-07-14 | 2016-07-14 | Traditional Chinese medicinal preparation for treating cerebral concussion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610584074.3A CN106038908A (en) | 2016-07-14 | 2016-07-14 | Traditional Chinese medicinal preparation for treating cerebral concussion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038908A true CN106038908A (en) | 2016-10-26 |
Family
ID=57417374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610584074.3A Pending CN106038908A (en) | 2016-07-14 | 2016-07-14 | Traditional Chinese medicinal preparation for treating cerebral concussion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106038908A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770440A (en) * | 2016-03-24 | 2016-07-20 | 刘军 | Traditional Chinese medicine preparation for treating cerebral concussion |
| CN105998842A (en) * | 2016-07-09 | 2016-10-12 | 来永广 | Traditional Chinese medicine preparation for treating cholecystitis due to qi stagnation and blood stasis |
| CN106109930A (en) * | 2016-06-27 | 2016-11-16 | 王玉霞 | A kind of Chinese medicine preparation treating lumbago and skelalgia and preparation method |
| CN106138246A (en) * | 2016-07-26 | 2016-11-23 | 刘永亮 | A kind of Chinese medicine preparation treating Anchylosis |
-
2016
- 2016-07-14 CN CN201610584074.3A patent/CN106038908A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770440A (en) * | 2016-03-24 | 2016-07-20 | 刘军 | Traditional Chinese medicine preparation for treating cerebral concussion |
| CN106109930A (en) * | 2016-06-27 | 2016-11-16 | 王玉霞 | A kind of Chinese medicine preparation treating lumbago and skelalgia and preparation method |
| CN105998842A (en) * | 2016-07-09 | 2016-10-12 | 来永广 | Traditional Chinese medicine preparation for treating cholecystitis due to qi stagnation and blood stasis |
| CN106138246A (en) * | 2016-07-26 | 2016-11-23 | 刘永亮 | A kind of Chinese medicine preparation treating Anchylosis |
Non-Patent Citations (1)
| Title |
|---|
| 吴学勤等: "大成汤加减治疗脑震荡65例临床观察", 《宁夏医学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101444611B (en) | Traditional Chinese medicine composition for treating lumbocrural pain and lumbar intervertebral disc protrusion and preparation method thereof | |
| CN101549059B (en) | Medicament for treating bronchial asthma and preparation method thereof | |
| CN101045137A (en) | Capsule for treating epilepsia and its preparing method | |
| CN104524247B (en) | One treats migrainous medical composition and its use | |
| KR102327197B1 (en) | Composition for preventing or treating neuropathic pain comprising extracts of herbal mixture | |
| CN107115408A (en) | It is a kind of to reduce the medicine of methotrexate (MTX) side effect | |
| CN104189289B (en) | A kind of Chinese medicine for the treatment of acute icterohepatitis and preparation method thereof | |
| CN104001057B (en) | For treating the heart schizoid medicine of kidney disorder type and preparation method thereof | |
| CN106038908A (en) | Traditional Chinese medicinal preparation for treating cerebral concussion | |
| CN108295168B (en) | Traditional Chinese medicine composition for treating post-stroke depression | |
| CN102552841B (en) | Traditional Chinese medicine for treating apoplexy sequelae | |
| CN1209162C (en) | Medicinal composition for treating acne and chloasma | |
| CN104740210B (en) | A kind of Chinese medicine and preparation method for the treatment of qi stagnation and blood stasis type craniocerebral trauma syndrome | |
| CN105998843A (en) | Traditional Chinese medicine preparation for treating recurring type dental ulcers | |
| CN116211974B (en) | Traditional Chinese medicine composition for improving microcirculation of human body | |
| CN111643606B (en) | Gel plaster for treating insomnia and preparation method thereof | |
| CN106138246A (en) | A kind of Chinese medicine preparation treating Anchylosis | |
| CN107158188A (en) | A kind of Chinese medicine preparation for promoting fractures and bone injuries to heal | |
| CN106266595A (en) | A kind of Chinese medicine preparation treating bronchial asthma | |
| CN107582792A (en) | A kind of oral traditional Chinese medicine granule and preparation method for treating Child trauma fracture early stage swelling and pain | |
| CN105194498B (en) | A kind of Chinese medicine composition and preparation method thereof for treating senile dementia | |
| CN110934996A (en) | Composition and preparation for treating mild dementia and application thereof | |
| CN106177355A (en) | A kind of Chinese medicine preparation treating fracture swelling | |
| Huang et al. | Covid-19 from Traditional Chinese Medicine Perspective: Severe Clinical Cases in the Context of Syndrome Differentiation | |
| CN106236956A (en) | A kind of Chinese medicine preparation treating fungal keratitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
|
| RJ01 | Rejection of invention patent application after publication |