CN106037747B - Muroid toes swelling analyzer - Google Patents
Muroid toes swelling analyzer Download PDFInfo
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- CN106037747B CN106037747B CN201610336505.4A CN201610336505A CN106037747B CN 106037747 B CN106037747 B CN 106037747B CN 201610336505 A CN201610336505 A CN 201610336505A CN 106037747 B CN106037747 B CN 106037747B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1073—Measuring volume, e.g. of limbs
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Abstract
The invention discloses a kind of muroid toes swelling analyzers, belong to pharmacology fixture technology field, total board is cuboid, total board upper end side is equipped with gravity column, gravity column is bolted the gravity sensor of test desk and total board lower end, gravity sensor one end connects sensor support, and the other end connects gravity support, and measuring cup is placed in test desk upper end;Total board upper end other side is bolted column support, column support top is bolted upper head plate, column support front end is equipped with elevating screw thread bar, elevating screw thread bar upper end is mounted on the motor fixing plate on upper head plate on rotational fixture and connects rotational fixture motor by being bolted lifter plate, motor fixing plate one end by lifter plate screw hole;It measures circuit board and is equipped with sense channel, sense channel is electrically connected LM358 direct current signal amplification modules, and LM358 direct current signal amplification modules connect gravity sensor, measures circuit board electrical connection RS232 communication ports, and RS232 communication ports connect computer.
Description
Technical field
The present invention relates to a kind of muroid toes swelling analyzers, belong to pharmacology fixture technology field.
Background technology
At present in pharmacological animal experiment, mouse toes swelling analyzer can measure the data of mouse toes swelling, still,
Mouse is positioned due to bad in the measurements, it is that side position is fixed that existing muroid, which fixes removable cover, and toes are exposed small, measure essence
It spends low, causes measurement data inaccurate.
Invention content
In order to overcome above-mentioned deficiency, the present invention to provide a kind of muroid toes swelling analyzer, which measures
Instrument can fix experimental mouse precision, with the method weighed by volume in a manner of gravity with control source AD converter, pass through
RS232 interface is passed to microcomputer, mouse toe swelling rate is calculated under software support, and can as needed rotate fixed experimental mouse,
It is accurate to measure numerical value.
The technical scheme is that:Total board is cuboid, and lower end quadrangle is respectively equipped with four total board columns, always
Board upper end side is equipped with gravity column, and gravity column is bolted the gravity sensor of test desk and total board lower end, gravity sensitive
Device one end connects sensor support, and the other end connects gravity support, and measuring cup is placed in test desk upper end;Total board upper end other side bolt
Column support is connected, column support upper and lower side is respectively equipped with limit switch frame, and limit switch frame side is equipped with limit switch;Column support top
Terminal bolt connects upper head plate, and column support front end is equipped with elevating screw thread bar, and elevating screw thread bar upper end is mounted on upper head plate, lifts spiral shell
Rasp bar lower end connection lifting stepper motor, lifting stepper motor are fixedly connected on total board lower end, elevating screw thread bar both ends difference
Equipped with optical axis is oriented to, it is oriented to optical axis upper end and is mounted on upper head plate, lower end is mounted on total board;Lifter plate is rectangle, lifting
Corresponding elevating screw thread bar position is equipped with screw insert among plate, and the corresponding optical axis position that is oriented to is respectively equipped with linear bearing, lifter plate
It mounted on elevating screw thread bar and is oriented on optical axis, elevating screw thread bar is engaged with screw insert, and linear bearing is slided along optical axis is oriented to;
Lifter plate end is equipped with screw hole, the motor fixing plate on rotational fixture by lifter plate screw hole by being bolted lifter plate, electricity
Machine fixed plate one end connects rotational fixture motor, motor fixing plate other end connecting bottom board seat, bottom block connecting bottom board;Muroid
Toes swelling analyzer circuit:It measures circuit board and connects 220v AC powers, measure circuit board and be equipped with sense channel, sense channel
LM358 direct current signal amplification modules are electrically connected, LM358 direct current signal amplification modules connect gravity sensor, and gravity sensor connects
Connect 12v batteries;Circuit board electrical connection RS232 communication ports are measured, RS232 communication ports connect computer;Measure circuit board electrical connection liter
Motor driver drops, and lifting motor driver is electrically connected lifting motor;Measure circuit board electrical connection electric rotating machine driver, rotation
Motor driver is electrically connected electric rotating machine;It measures circuit board and is equipped with input control power supply, measure circuit board and be equipped with output control electricity
Source switch, output control power switch are electrically connected contact relay, and relay is separately connected two groups of 24v batteries, one group of battery and all the way
Relay connects lifting motor driver, and another group of battery connects electric rotating machine driver with another way relay.
The beneficial effects of the invention are as follows:Can stretch out toes in maximum magnitude, convenient for measuring the volume and volume of toes
Variation.The revolving structure of stepper motor can Precision trimming toes orientation downward vertically, for gravitational method measure volume prepare
The spatial position of good toes.It is equally applicable to the cubing of rat-tail.Pressure head component can push down mouse head.Rotate lid Anchor plate kit and
Compressing purl component can be with quick-replaceable rat.
Description of the drawings
The present invention is further described with reference to the accompanying drawings and detailed description.
Fig. 1 is muroid toes swelling analyzer structure chart of the present invention.
Fig. 2 is muroid toes swelling analyzer front view of the present invention.
Fig. 3 is muroid toes swelling analyzer side view of the present invention.
Fig. 4 is muroid toes swelling analyzer fixer structure decomposition diagram of the present invention.
Fig. 5 is muroid toes swelling analyzer circuit connection diagram of the present invention.
Fig. 6 is muroid toes swelling analyzer control page schematic diagram of the present invention.
1 in figure, total board, 2, lifting stepper motor, 3, total board column, 4, limit switch, 5, limit switch frame, 6, rise
Threaded rod drops, and 7, column support, 8, be oriented to optical axis, 9, screw insert, 10, lifter plate, 11, linear bearing, 12, upper head plate, 13, solid
Determine device motor, 14, motor fixing plate, 15, bottom block, 16, bottom plate, 17, measuring cup, 18, test desk, 19, gravity column, 20, again
Power support, 21 gravity sensors, 22, sensor column, 23, sensor support, 24, LM358 direct current signal amplification modules, 25, RS232 it is logical
Interrogate mouth, 26, input control power supply, 27, output control power switch, 28, relay, 29, electric rotating machine driver, 30, lifting
Motor driver, 31, measure circuit board.
Specific implementation mode
As Figure 1-Figure 4, total board 1 is cuboid, and lower end quadrangle is respectively equipped with four total board columns 3, assembly
1 upper end side of plate is equipped with gravity column 19, and gravity column 19 is bolted the gravity sensor 21 of 1 lower end of test desk 18 and total board,
21 one end of gravity sensor connects sensor support 23, and the other end connects gravity support 20, and measuring cup 17 is placed in 18 upper end of test desk;Always
The 1 upper end other side of board is bolted column support 7, and 7 upper and lower side of column support is respectively equipped with limit switch frame 5,5 side of limit switch frame
End is equipped with limit switch 4;7 top of column support is bolted upper head plate 12, and 7 front end of column support is equipped with elevating screw thread bar 6, lifts spiral shell
6 upper end of rasp bar is mounted on upper head plate 12, and 6 lower end of elevating screw thread bar connection lifting stepper motor 2, lifting stepper motor 2 is fixed
It is connected to 1 lower end of total board, 6 both ends of elevating screw thread bar, which are respectively equipped with, is oriented to optical axis 8, is oriented to 8 upper end of optical axis and is mounted on upper head plate
On 12, lower end is mounted on total board 1;Lifter plate 10 is rectangle, and 6 position of elevating screw thread bar is corresponded among lifter plate 10 and is equipped with spiral shell
Line silk braid 9, corresponding 8 position of optical axis that is oriented to are respectively equipped with linear bearing 11, and lifter plate 10 is mounted on elevating screw thread bar 6 and is oriented to light
On axis 8, elevating screw thread bar 6 is engaged with screw insert 9, and linear bearing 11 is slided along optical axis 8 is oriented to;10 end of lifter plate is equipped with spiral shell
Hole, the motor fixing plate 14 on rotational fixture is by 10 screw hole of lifter plate by being bolted lifter plate 10, motor fixing plate 14
One end connects rotational fixture motor 13,14 other end connecting bottom board seat 15 of motor fixing plate, 15 connecting bottom board 16 of bottom block;Mouse
Class toes swelling analyzer circuit connects 220v AC powers as shown in figure 5, measuring circuit board 31, measures circuit board 31 and is equipped with inspection
Channel is surveyed, sense channel is electrically connected LM358 direct current signals amplification module 24, and LM358 direct current signals amplification module 24 connects gravity
Sensor 21, gravity sensor 21 connect 12v batteries;It measures circuit board 31 and is electrically connected RS232 communication ports 25, RS232 communication ports
25 connection computers;It measures circuit board 31 and is electrically connected lifting motor driver 30, lifting motor driver 30 is electrically connected lifting motor
2;It measures circuit board 31 and is electrically connected electric rotating machine driver 29, electric rotating machine driver 29 is electrically connected electric rotating machine 13;Measure electricity
Road plate 31 is equipped with input control power supply 26, measures circuit board 31 and is equipped with output control power switch 27, output control power switch
27 are electrically connected contact relay 28, and relay 28 is separately connected two groups of 24v batteries, and one group of battery connects lifting motor with relay all the way
Driver 30, another group of battery connect electric rotating machine driver 29 with another way relay.
The rotational fixture structure is:Rotational fixture motor 13 is fixed on by screw on motor fixing plate 14, rotation
13 axis of fixator motor is fixed by screws in bottom block 15, and bottom block 15 passes through screw connection bottom plate 16, bottom plate 16 1
End left and right ends are respectively equipped with two bar shaped boss, and 16 both ends of bottom plate are respectively equipped with five screw holes, and fixed cover is bonded in bottom plate
On boss, removable cover is aligned placement, the arcwall face flush of removable cover and fixed cover upper end with fixed cover;The fixed cover and work
Dynamic lid shape is all mutually " u "-shaped frame, and the " u "-shaped frame both ends of removable cover are respectively equipped with four limbs body opening, fixed cover and removable cover arc
End is respectively equipped with bar shaped socket, and bar shaped spigot is inserted into rat-tail limiting plate;Fixed cover combines place's " u "-shaped frame with removable cover abutment joint
Both ends are respectively equipped with four limbs body opening, while fixed cover is respectively equipped with four limbs with the removable cover abutment joint place of combination " u "-shaped frame both ends
Hole, at the abutment joint combination half of the four limbs body opening at " u "-shaped frame both ends be respectively positioned in fixed cover, at the abutment joint combination
Another half of the four limbs body opening at " u "-shaped frame both ends is respectively positioned on removable cover;
Sponge compression spring patch cementation is scheduled on lid pressing plate;Lid pressing plate is rectangle, and one end is equipped with the rectangular boss other end and is equipped with " U "
The boss of shape slot, lid pressing plate laterally penetrates an axis, and axis both ends respectively penetrate stern post front end, and the stern post other end passes through screw
It is fixedly connected on bottom plate;It is equipped with pressure head slide plate among two bar shaped boss of the bottom plate other end, is consolidated by head slide plate fixed screw
It is scheduled on bottom plate, pressure head slide plate is rectangle groove body, and both side plate is trapezoidal plate;Two trapezoidal plates of pressure head slide plate are equipped with screw hole, pressure
Head plate is mounted in the slot among two trapezoidal plates of pressure head slide plate, solid in the screw hole on two trapezoidal plates of pressure head slide plate by screw
Fixed, above-mentioned head slide plate fixed screw, pressure head plate and pressure head slide plate form pressure head component;The "u"-shaped groove both ends of lid pressing plate are solid respectively
There is lid pressing plate shaft in Dingan County;Lock tube is cylinder, and one end is equipped with the cavity of installation lock piston, and the diameter locked in piston cavity is more than
The outer diameter of piston is locked, the lock tube other end is equipped with the hole of installation purl, and lock piston one end is equipped with the cavity of installation lock compression spring, the other end
Hole equipped with installation purl, purl interference fit are inserted into the hole of lock tube, and purl interference fit is inserted into the hole of lock piston, lock pressure
Spring is inserted into the cavity of lock piston, and lock piston and lock compression spring are inserted into the cavity of lock tube simultaneously, and above-mentioned lock tube, lock compression spring, lock are lived
Plug and purl composition compression purl component;Headpin is cylinder, and one end is equipped with screw hole, axial bar groove is equipped among the other end, with
Axial bar groove is perpendicular to be equipped with through-hole, and the purl at compression purl component both ends is inserted into the through-hole of headpin respectively, on lid pressing plate
Lid pressing plate shaft is inserted into the axial bar groove of headpin, and the screw hole end of headpin is by fastened by screw on bottom plate.
Rat is placed in by cephlad-caudal on bottom plate, rat four limbs are stretched out from removable cover and the four limbs body opening of fixed cover,
Rat is pushed down with removable cover;Pressure head plate pushes down removable cover, and 2 lid pressing plate shafts are pushed down with compression purl component.After having measured, start
Motor drives other mouse toes of rat wheel measuring.
Telemetry circuit plate controls bottom plate and sits lifting, and the rotation of muroid rotational fixture measures gravitational cue corresponding with volume,
Gravity voltage signal is passed to microcomputer by RS232 interface.Telemetry circuit plate control lifting stepper motor 2, makes muroid revolve
Turn fixator to move up and down, be powered with four core winding displacements, four core winding displacements penetrate cabinet from upper head plate 8, upper limit position switch power supply from
Upper head plate 8 penetrates cabinet, and lower position switch power supply penetrates cabinet from total board 1.Telemetry circuit plate controls decelerating step motor
11, so that muroid rotational fixture is rotated, the reduction ratio of decelerating step motor is 100:1.Telemetry circuit plate has voltage measurement all the way,
The d. c. voltage signal that gravity sensor 15 inputs is received, LM358 direct current signal amplification modules amplify 100 times, turn using AD
Parallel operation is converted into digital quantity, and microcomputer is passed to through RS232 interface.When two motor movements, two-way relay is connected, 24V DC direct currents
Power supply powers to stepper motor;When measuring gravitational cue, two-way relay disconnects, and 24V DC DC power supplies stop to stepping electricity
Machine is powered.24V DC DC power supplies power to LM358 direct current signal amplification modules.There are 8 1.5V batteries series connection in battery case,
12V DC are provided to gravity sensor 15.
The present invention has developed SMI4 toes swelling analyzer softwares, is write using VB6 language.Software interface as shown in figure 4,
The software interface setting of rotation is counterclockwise and rotates clockwise button, and rotation angle quantitative setting is in Text1 text boxes, with tune
Zero presses benchmark, adjusts to the toes of mouse and keeps lead direction.The software interface setting of lifting rises and drop rotation button, rises to peak
When with height zero-setting button tune zero, as height base benchmark.Falling head can arbitrarily add up setting, and repeat to be reduced to phase
Same height.Weight-calibration scheme:Make the zero that adjustment measures using peeling button, uses 100.000 grams of weights calibration weights
The sensitivity of measurement.The scheme for measuring mouse toes swelling rate is the normal volume mL first clicked in mouse toes swelling rate % tables
The cell of row and column is clicked and measures button;Click the unit of the row and column of the swelling volume mL in mouse toes swelling rate % tables
Lattice are clicked and measure button;The computed push-buttom in mouse toes swelling rate % tables is clicked, shows swelling rate % in the table.
Claims (1)
1. a kind of muroid toes swelling analyzer, it is characterised in that:Total board(1)For cuboid, lower end quadrangle is respectively equipped with
Four total board columns(3), total board(1)Upper end side is equipped with gravity column(19), gravity column(19)It is bolted test desk
(18)With total board(1)The gravity sensor of lower end(21), gravity sensor(21)One end connects sensor support(23), the other end
Connect gravity support(20), test desk(18)Place measuring cup in upper end(17);Total board(1)The upper end other side is bolted column support
(7), column support(7)Upper and lower side is respectively equipped with limit switch frame(5), limit switch frame(5)Side is equipped with limit switch(4);It is vertical
Pylon(7)Top is bolted upper head plate(12), column support(7)Front end is equipped with elevating screw thread bar(6), elevating screw thread bar(6)On
End is mounted on upper head plate(12)On, elevating screw thread bar(6)Lower end connection lifting stepper motor(2), lift stepper motor(2)It is fixed
It is connected to total board(1)Lower end, elevating screw thread bar(6)Both ends are respectively equipped with guiding optical axis(8), it is oriented to optical axis(8)It installs upper end
In upper head plate(12)On, lower end is mounted on total board(1)On;Lifter plate(10)For rectangle, lifter plate(10)The corresponding lifting in centre
Threaded rod(6)Position is equipped with screw insert(9), corresponding to be oriented to optical axis(8)Position is respectively equipped with linear bearing(11), lifter plate
(10)Mounted on elevating screw thread bar(6)With guiding optical axis(8)On, elevating screw thread bar(6)With screw insert(9)Engagement, linear axis
It holds(11)Along guiding optical axis(8)Sliding;Lifter plate(10)End is equipped with screw hole, the motor fixing plate on rotational fixture(14)It is logical
Cross lifter plate(10)Screw hole is by being bolted lifter plate(10), motor fixing plate(14)One end connects rotational fixture motor
(13), motor fixing plate(14)Other end connecting bottom board seat(15), bottom block(15)Connecting bottom board(16);Muroid toes swelling is surveyed
Determine instrument circuit:Measure circuit board(31)220v AC powers are connected, circuit board is measured(31)Equipped with sense channel, sense channel electricity
Connect LM358 direct current signal amplification modules(24), LM358 direct current signal amplification modules(24)Connect gravity sensor(21), weight
Force snesor(21)Connect 12v batteries;Measure circuit board(31)It is electrically connected RS232 communication ports(25), RS232 communication ports(25)Even
Connect computer;Measure circuit board(31)It is electrically connected lifting motor driver(30), lifting motor driver(30)Electrical connection lifting electricity
Machine(2);Measure circuit board(31)It is electrically connected electric rotating machine driver(29), electric rotating machine driver(29)It is electrically connected electric rotating machine
(13);Measure circuit board(31)Equipped with input control power supply(26), measure circuit board(31)Power switch is controlled equipped with output
(27), output control power switch(27)Be electrically connected contact relay(28), relay(28)It is separately connected two groups of 24v batteries, one group
Battery connects lifting motor driver with relay all the way(30), another group of battery connected with another way relay electric rotating machine drive
Dynamic device(29);The rotational fixture structure is:Rotational fixture motor(13)Motor fixing plate is fixed on by screw(14)On,
Rotational fixture motor(13)Axis is fixed by screws bottom block(15)It is interior, bottom block(15)Pass through screw connection bottom plate
(16), bottom plate(16)One end left and right ends are respectively equipped with two bar shaped boss, bottom plate(16)Both ends are respectively equipped with five screw holes, Gu
Fixed lid is bonded on the boss of bottom plate, and removable cover is aligned placement with fixed cover, and removable cover is equal with the arcwall face of fixed cover upper end
Together;The fixed cover is all mutually " u "-shaped frame with removable cover shape, and the " u "-shaped frame both ends of removable cover are respectively equipped with four limbs body opening, Gu
Fixed lid is respectively equipped with bar shaped socket with removable cover arc tips, and bar shaped spigot is inserted into rat-tail limiting plate;Fixed cover and removable cover pair
" u "-shaped frame both ends are respectively equipped with four limbs body opening at seam combination, while fixed cover combines place's " u "-shaped frame two with removable cover abutment joint
End is respectively equipped with four limbs body opening, at the abutment joint combination half of the four limbs body opening at " u "-shaped frame both ends be respectively positioned in fixed cover,
Another half of the four limbs body opening at " u "-shaped frame both ends is respectively positioned on removable cover at the abutment joint combination;It is fixed that sponge compression spring pastes cementation
On lid pressing plate;Lid pressing plate is rectangle, and one end is equipped with the rectangular boss other end and is equipped with "u"-shaped groove, and the boss of lid pressing plate is laterally worn
Enter an axis, axis both ends respectively penetrate stern post front end, and the stern post other end is fixed by screws on bottom plate;Bottom plate is another
It is equipped with pressure head slide plate among two bar shaped boss of one end, is fixed on bottom plate by head slide plate fixed screw, pressure head slide plate is square
Shape groove body, both side plate are trapezoidal plate;Two trapezoidal plates of pressure head slide plate are equipped with screw hole, and pressure head plate is mounted on two ladders of pressure head slide plate
It is fixed in the screw hole on two trapezoidal plates of pressure head slide plate by screw in slot among shape plate, above-mentioned head slide plate fixed screw, pressure
Head plate and pressure head slide plate form pressure head component;The "u"-shaped groove both ends of lid pressing plate are fixed respectively to be equipped with lid pressing plate shaft;Lock tube is cylinder
Body, one end are equipped with the cavity of installation lock piston, lock the outer diameter that the diameter in piston cavity is more than lock piston, and the lock tube other end is set
There are the hole of installation purl, lock piston one end to be equipped with the cavity of installation lock compression spring, the other end is equipped with the hole of installation purl, purl interference
Cooperation is inserted into the hole of lock tube, and purl interference fit is inserted into the hole of lock piston, and lock compression spring is inserted into the cavity of lock piston, and lock is lived
Plug and lock compression spring are inserted into the cavity of lock tube simultaneously, above-mentioned lock tube, lock compression spring, lock piston and purl composition compression purl component;
Headpin is cylinder, and one end is equipped with screw hole, axial bar groove is equipped among the other end, perpendicular equipped with through-hole, pressure with axial bar groove
The purl at contracting purl component both ends is inserted into the through-hole of headpin respectively, and the lid pressing plate shaft on lid pressing plate is inserted into the axial bars of headpin
In slot, the screw hole end of headpin is by fastened by screw on bottom plate.
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CN201610336505.4A CN106037747B (en) | 2016-06-16 | 2016-06-16 | Muroid toes swelling analyzer |
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CN201610336505.4A CN106037747B (en) | 2016-06-16 | 2016-06-16 | Muroid toes swelling analyzer |
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CN106037747B true CN106037747B (en) | 2018-08-31 |
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Citations (7)
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SU1233863A1 (en) * | 1984-06-27 | 1986-05-30 | Иркутский Государственный Медицинский Институт | Apparatus for measuring volume of rotary movements in knee joint |
CN201036553Y (en) * | 2007-06-06 | 2008-03-19 | 娄建石 | Experimental device for measuring animal toe swelling |
CN202437120U (en) * | 2012-01-19 | 2012-09-19 | 德州学院 | Rat paw edema measuring device |
CN202505353U (en) * | 2011-12-30 | 2012-10-31 | 熊智 | Experiment device for measuring swelling volumes of toes of large and small mice |
CN103549937A (en) * | 2013-11-07 | 2014-02-05 | 中国医科大学附属第一医院 | Tissue-swelling measurement instrument and control method thereof |
CN203619532U (en) * | 2013-11-07 | 2014-06-04 | 中国医科大学附属第一医院 | Tissue swelling measuring instrument |
CN204363956U (en) * | 2014-12-15 | 2015-06-03 | 西北民族大学 | Body surface swelling measuring instrument |
-
2016
- 2016-06-16 CN CN201610336505.4A patent/CN106037747B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1233863A1 (en) * | 1984-06-27 | 1986-05-30 | Иркутский Государственный Медицинский Институт | Apparatus for measuring volume of rotary movements in knee joint |
CN201036553Y (en) * | 2007-06-06 | 2008-03-19 | 娄建石 | Experimental device for measuring animal toe swelling |
CN202505353U (en) * | 2011-12-30 | 2012-10-31 | 熊智 | Experiment device for measuring swelling volumes of toes of large and small mice |
CN202437120U (en) * | 2012-01-19 | 2012-09-19 | 德州学院 | Rat paw edema measuring device |
CN103549937A (en) * | 2013-11-07 | 2014-02-05 | 中国医科大学附属第一医院 | Tissue-swelling measurement instrument and control method thereof |
CN203619532U (en) * | 2013-11-07 | 2014-06-04 | 中国医科大学附属第一医院 | Tissue swelling measuring instrument |
CN204363956U (en) * | 2014-12-15 | 2015-06-03 | 西北民族大学 | Body surface swelling measuring instrument |
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