CN106037747A - Murine toe swelling tester - Google Patents
Murine toe swelling tester Download PDFInfo
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- CN106037747A CN106037747A CN201610336505.4A CN201610336505A CN106037747A CN 106037747 A CN106037747 A CN 106037747A CN 201610336505 A CN201610336505 A CN 201610336505A CN 106037747 A CN106037747 A CN 106037747A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1073—Measuring volume, e.g. of limbs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Percussion Or Vibration Massage (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a murine toe swelling tester, belonging to the technical field of pharmacological appliances. A total bearing plate is a rectangular body, a gravity pillar is arranged at one side of the upper end of the total bearing plate, the gravity pillar is connected with a measurement platform and a gravity sensor at the lower end of the total bearing plate by bolts, one end of the gravity sensor is connected with a sensor support, the other end of the gravity sensor is connected with a gravity support, and a measurement cup is placed on the upper end of the measurement platform; the other side of the upper end of the total bearing plate is connected with a stand column frame by bolts, the top end of the stand column frame is connected with an upper end plate by bolts, a lifting threaded rod is arranged at the front end of the stand column frame, the upper end of the lifting threaded rod is mounted on the upper end plate, a motor fixing plate of a rotation fixator is connected with a lifting board by a bolt through threaded holes of the lifting board, and one end of the motor fixing plate is connected with a rotation fixator motor; a detection channel is arranged on a measurement circuit board, and is electrically connected with an LM 358 direct current signal amplification module, the LM 358 direct current signal amplification module is connected with the gravity sensor, the measurement circuit board is electrically connected with an RS 232 communication port, and the RS 232 communication port is connected with a computer.
Description
Technical field
The present invention relates to a kind of muroid toes swelling analyzer, belong to pharmacology's fixture technology field.
Background technology
At present in pharmacological animal is tested, Mus toes swelling analyzer can measure the data of Mus toes swelling, but,
Positioning Mus due to bad in the measurements, it is that position, side is fixed that existing muroid fixes removable cover, and the exposed volume of toes is little, measures essence
Spend low, cause measurement data inaccurate.
Summary of the invention
In order to overcome above-mentioned deficiency, the present invention provides a kind of muroid toes swelling analyzer, and this muroid toes swelling measures
Experimental mouse precision can be fixed by instrument, by the method weighed, with gravity mode voltage, volume is inputted a/d converter, passes through
The incoming microcomputer of RS232 interface, calculates Mus toe swelling rate under software support, and can fixing experimental mouse be rotated as required,
Mensuration numerical value is accurate.
The technical scheme is that total board is cuboid, its corner, lower end is respectively equipped with four total board columns, always
Side, board upper end is provided with gravity post, and gravity post bolt connects test desk and the gravity sensor of total board lower end, gravity sensitive
Device one end connects sensor torr, and the other end connects gravity torr, and measuring cup is laid in test desk upper end；Total board upper end opposite side bolt
Connecting column support, column support upper and lower side is respectively equipped with limit switch frame, and limit switch frame side is equipped with limit switch；Column support top
Terminal bolt connects upper head plate, and column support front end is provided with elevating screw thread bar, and elevating screw thread bar upper end is arranged on upper head plate, lifts spiral shell
Rasp bar lower end connects lifting motor, and lifting motor is fixedly connected on total board lower end, and elevating screw thread bar two ends are respectively
Being provided with guiding optical axis, guide optical axis upper end and be arranged on upper head plate, lower end is arranged on total board；Lifter plate is rectangle, lifting
In the middle of plate, corresponding elevating screw thread bar position is provided with screw insert, and the corresponding optical axis position that guides is respectively equipped with linear bearing, lifter plate
Being arranged on elevating screw thread bar and guide on optical axis, elevating screw thread bar engages with screw insert, and linear bearing slides along guiding optical axis；
Lifter plate termination is provided with screw, and the motor fixing plate on rotational fixture is connected lifter plate by lifter plate screw by bolt, electricity
Machine fixed plate one end connects rotational fixture motor, motor fixing plate other end connecting bottom board seat, bottom block connecting bottom board；Muroid
Toes swelling analyzer circuit: measure circuit board and connect 220v alternating current power supply, measures circuit board and is provided with sense channel, sense channel
Electrical connection LM358 direct current signal amplification module, LM358 direct current signal amplification module connects gravity sensor, and gravity sensor is even
Connect 12v battery；Measuring circuit board electrical connection RS232 communication port, RS232 communication port connects computer；Measure circuit board electrical connection to rise
Fall motor driver, lifting motor driver electrical connection lifting motor；Measure circuit board electrical connection electric rotating machine driver, rotate
Motor driver electrical connection electric rotating machine；Measuring circuit board and be provided with input control power supply, mensuration circuit board is provided with output and controls electricity
Source switch, output controls on and off switch electrical connection relay, and relay connects two groups of 24v batteries, a Battery pack and a road respectively
Relay connects lifting motor driver, another Battery pack and another road relay and connects electric rotating machine driver.
The invention has the beneficial effects as follows: can stretch out toes in maximum magnitude, it is simple to measure volume and the volume of toes
Change.The revolving structure of motor can the orientation downward vertically of Precision trimming toes, measure volume for gravitational method and prepare
The locus of good toes.It is equally applicable to the cubing of rat-tail.Pressure head component can push down Mus head.Swivelling cover Anchor plate kit and
Compression purl assembly can be with quick-replaceable rat.
Accompanying drawing explanation
The present invention is further described with detailed description of the invention below in conjunction with the accompanying drawings.
Fig. 1 is muroid toes swelling analyzer structure chart of the present invention.
Fig. 2 is muroid toes swelling analyzer front view of the present invention.
Fig. 3 is muroid toes swelling analyzer side view of the present invention.
Fig. 4 is muroid toes swelling analyzer fixer structure decomposing schematic representation of the present invention.
Fig. 5 is muroid toes swelling analyzer circuit connection diagram of the present invention.
Fig. 6 is that muroid toes swelling analyzer of the present invention controls page schematic diagram.
In figure 1, total board, 2, lifting motor, 3, total board column, 4, limit switch, 5, limit switch frame, 6, rise
Fall threaded rod, 7, column support, 8, guide optical axis, 9, screw insert, 10, lifter plate, 11, linear bearing, 12, upper head plate, 13, solid
Determine device motor, 14, motor fixing plate, 15, bottom block, 16, base plate, 17, measuring cup, 18, test desk, 19, gravity post, 20, weight
Power torr, 21 gravity sensors, 22, sensor post, 23, sensor torr, 24, LM358 direct current signal amplification module, 25, RS232 leads to
News mouth, 26, input control power supply, 27, output control on and off switch, 28, relay, 29, electric rotating machine driver, 30, lifting
Motor driver, 31, measure circuit board.
Detailed description of the invention
As Figure 1-Figure 4, total board 1 is cuboid, and its corner, lower end is respectively equipped with four total board columns 3, assembly
Side, plate 1 upper end is provided with gravity post 19, and gravity post 19 bolt connects test desk 18 and the gravity sensor 21 of total board 1 lower end,
Gravity sensor 21 one end connects sensor torr 23, and the other end connects gravity torr 20, and measuring cup 17 is laid in test desk 18 upper end；Always
Board 1 upper end opposite side bolt connects column support 7, and column support 7 upper and lower side is respectively equipped with limit switch frame 5, limit switch frame 5 side
End is equipped with limit switch 4；Column support 7 top bolt connects upper head plate 12, and column support 7 front end is provided with elevating screw thread bar 6, lifts spiral shell
Rasp bar 6 upper end is arranged on upper head plate 12, and elevating screw thread bar 6 lower end connects lifting motor 2, and lifting motor 2 is fixed
Being connected to total board 1 lower end, elevating screw thread bar 6 is respectively arranged at two ends with guiding optical axis 8, guides optical axis 8 upper end and is arranged on upper head plate
On 12, lower end is arranged on total board 1；Lifter plate 10 is rectangle, and in the middle of lifter plate 10, corresponding elevating screw thread bar 6 position is provided with spiral shell
Stricture of vagina silk braid 9, corresponding optical axis 8 position that guides is respectively equipped with linear bearing 11, and lifter plate 10 is arranged on elevating screw thread bar 6 and guides light
On axle 8, elevating screw thread bar 6 engages with screw insert 9, and linear bearing 11 slides along guiding optical axis 8；Lifter plate 10 termination is provided with spiral shell
Hole, the motor fixing plate 14 on rotational fixture is connected lifter plate 10, motor fixing plate 14 by lifter plate 10 screw by bolt
One end connects rotational fixture motor 13, motor fixing plate 14 other end connecting bottom board seat 15, bottom block 15 connecting bottom board 16；Mus
Class toes swelling analyzer circuit connects 220v alternating current power supply as it is shown in figure 5, measure circuit board 31, measures circuit board 31 and is provided with inspection
Surveying passage, sense channel electrical connection LM358 direct current signal amplification module 24, LM358 direct current signal amplification module 24 connects gravity
Sensor 21, gravity sensor 21 connects 12v battery；Measure circuit board 31 and electrically connect RS232 communication port 25, RS232 communication port
25 connect computer；Measuring circuit board 31 and electrically connect lifting motor driver 30, lifting motor driver 30 electrically connects lifting motor
2；Measuring circuit board 31 and electrically connect electric rotating machine driver 29, electric rotating machine driver 29 electrically connects electric rotating machine 13；Measure electricity
Road plate 31 is provided with input and controls power supply 26, measures circuit board 31 and is provided with output control on and off switch 27, and output controls on and off switch
27 electrical connection relays 28, relay 28 connects two groups of 24v batteries, a Battery pack and a road relay respectively and connects lifting motor
Driver 30, another Battery pack and another road relay connect electric rotating machine driver 29.
Described rotational fixture structure is: rotational fixture motor 13 is fixed on motor fixing plate 14 by screw, rotates
Holder motor 13 axle is screwed in connecting bottom board seat 15, and bottom block 15 is by screw connecting bottom board 16, base plate 16 1
Being respectively arranged at two ends with two bar shaped boss about end, base plate 16 is respectively arranged at two ends with five screws, and fixing lid is bonded in base plate
On boss, removable cover aligns with fixing lid and lays, removable cover and the fixing arcwall face flush covering end；Described fixing lid and work
Dynamic cap-shaped shape is all " u "-shaped frame mutually, and the " u "-shaped frame of removable cover is respectively arranged at two ends with extremity body opening, fixing lid and removable cover arc
End is respectively equipped with bar shaped socket, and bar shaped spigot inserts rat-tail limiting plate；" u "-shaped frame at fixing lid and removable cover abutment joint combination
It is respectively arranged at two ends with extremity body opening, fixing lid and removable cover are respectively equipped with half extremity body opening；Sponge stage clip patch cementation is scheduled on
On lid pressing plate；Lid pressing plate is rectangle, and one end is provided with the rectangular boss other end and is provided with " u "-shaped groove, and the boss of lid pressing plate laterally penetrates
One axis, axis two ends respectively penetrate stern post front end, and the stern post other end is screwed and is connected on base plate；Base plate another
Being equipped with pressure head slide plate in the middle of two bar shaped boss of end, head slide plate fixed screw be fixed on base plate, pressure head slide plate is rectangle
Cell body, biside plate is trapezoidal plate；Two trapezoidal plates of pressure head slide plate are provided with screw, and it is two trapezoidal that pressure head plate is arranged on pressure head slide plate
In groove in the middle of plate, by fixing in screw screw on two trapezoidal plates of pressure head slide plate, above-mentioned head slide plate fixed screw, pressure head
Plate and pressure head slide plate composition pressure head component；The " u "-shaped groove two ends of lid pressing plate are fixing respectively is equipped with lid pressing plate shaft；Lock tube is cylindrical
Body, one end is provided with the cavity installing lock piston, and the diameter in lock piston cavity is more than the external diameter of lock piston, and the lock tube other end is provided with
Installing the hole of purl, lock piston one end is provided with the cavity installing lock stage clip, and the other end is provided with the hole installing purl, and purl interference is joined
Closing in the hole inserting lock tube, purl interference fit is inserted in the hole of lock piston, and lock stage clip inserts in the cavity of lock piston, locks piston
It is inserted simultaneously in the cavity of lock tube with lock stage clip, above-mentioned lock tube, lock stage clip, lock piston and purl composition compression purl assembly；Head
Post is cylinder, and one end is provided with screw, is provided with axial bars groove in the middle of the other end, be provided with through hole perpendicular with axial bars groove, compression
The purl at purl assembly two ends inserts in the through hole of headpin respectively, and the lid pressing plate shaft on lid pressing plate is inserted into the axial bars groove of headpin
In, the screw end of headpin by fastened by screw on base plate.
Being placed on base plate by cephlad-caudal by rat, rat extremity stretch out from the extremity body opening of removable cover and fixing lid,
Rat is pushed down with removable cover；Removable cover pushed down by pressure head plate, pushes down 2 lid pressing plate shafts with compression purl assembly.After having measured, start
Other Mus toes of driven by motor rat wheel measuring.
Telemetry circuit plate controls base plate and sits lifting, and muroid rotational fixture rotates, and measures the gravitational cue corresponding with volume,
Gravity voltage signal passes through the incoming microcomputer of RS232 interface.Telemetry circuit plate controls lifting motor 2, makes muroid revolve
Turning holder to move up and down, power with four core winding displacements, four core winding displacements penetrate cabinet from upper head plate 8, upper limit position switch power from
Upper head plate 8 penetrates cabinet, and lower position switch is powered and penetrated cabinet from total board 1.Telemetry circuit plate controls decelerating step motor
11, make muroid rotational fixture rotate, the speed reducing ratio of decelerating step motor is 100:1.Telemetry circuit Ban You mono-tunnel voltage measurement,
Receiving the d. c. voltage signal of gravity sensor 15 input, LM358 direct current signal amplification module amplifies 100 times, then turns through AD
Parallel operation is converted into digital quantity, through the incoming microcomputer of RS232 interface.During two motor movements, two-way relay is connected, 24V DC direct current
Motor is powered by power supply；When measuring gravitational cue, two-way relay disconnects, and 24V DC DC source stops stepping electricity
Machine is powered.LM358 direct current signal amplification module is powered by 24V DC DC source.8 1.5V battery series connection are had in battery case,
12V DC is provided to gravity sensor 15.
The present invention have developed SMI4 toes swelling analyzer software, uses VB6 language to write.Software interface as shown in Figure 4,
The software interface rotated arranges the counterclockwise and button that turns clockwise, and anglec of rotation quantitative setting is in Text1 text box, with tune
Zero presses benchmark, adjusts the toes holding lead direction to Mus.The software interface of lifting arranges and rises and fall rotary knob, rises to peak
Time with height zero-setting button tune zero, as height base benchmark.Falling head can arbitrarily add up setting, and repeats to be reduced to phase
Same height.Weight-calibration scheme: the zero point using peeling button to make adjustment measure, uses 100.000 grams of weights calibration weights
The sensitivity measured.The scheme measuring Mus toes swelling rate is to first click on the normal volume mL in Mus toes swelling rate % table
The cell of row and column, clicks on and measures button；The unit of the row and column of the swelling volume mL in click Mus toes swelling rate % table
Lattice, click on and measure button；Click on the computed push-buttom in Mus toes swelling rate % table, show swelling rate % in the table.
Claims (1)
1. a muroid toes swelling analyzer, it is characterised in that: total board (1) is cuboid, and its corner, lower end is respectively equipped with
Four total board columns (3), total board (1) side, upper end is provided with gravity post (19), and gravity post (19) bolt connects test desk
(18) and the gravity sensor (21) of total board (1) lower end, gravity sensor (21) one end connects sensor torr (23), the other end
Connecting gravity torr (20), measuring cup (17) is laid in test desk (18) upper end；Total board (1) upper end opposite side bolt connects column support
(7), column support (7) upper and lower side is respectively equipped with limit switch frame (5), and limit switch frame (5) side is equipped with limit switch (4)；Vertical
Pylon (7) top bolt connects upper head plate (12), and column support (7) front end is provided with elevating screw thread bar (6), on elevating screw thread bar (6)
End is arranged on upper head plate (12), and elevating screw thread bar (6) lower end connects lifting motor (2), and lifting motor (2) is fixed
Being connected to total board (1) lower end, elevating screw thread bar (6) is respectively arranged at two ends with guiding optical axis (8), guides optical axis (8) upper end and installs
On upper head plate (12), lower end is arranged on total board (1)；Lifter plate (10) is rectangle, corresponding lifting in the middle of lifter plate (10)
Threaded rod (6) position is provided with screw insert (9), and corresponding optical axis (8) position that guides is respectively equipped with linear bearing (11), lifter plate
(10) being arranged on elevating screw thread bar (6) and guide on optical axis (8), elevating screw thread bar (6) engages with screw insert (9), linear axis
Hold (11) and slide along guiding optical axis (8)；Lifter plate (10) termination is provided with screw, and the motor fixing plate (14) on rotational fixture leads to
Crossing lifter plate (10) screw and connected lifter plate (10) by bolt, motor fixing plate (14) one end connects rotational fixture motor
(13), motor fixing plate (14) other end connecting bottom board seat (15), bottom block (15) connecting bottom board (16)；Muroid toes swelling is surveyed
Determine instrument circuit: measure circuit board (31) and connect 220v alternating current power supply, measure circuit board (31) and be provided with sense channel, sense channel electricity
Connecting LM358 direct current signal amplification module (24), LM358 direct current signal amplification module (24) connects gravity sensor (21), weight
Force transducer (21) connects 12v battery；Measuring circuit board (31) electrical connection RS232 communication port (25), RS232 communication port (25) is even
Connect computer；Measure circuit board (31) electrical connection lifting motor driver (30), lifting motor driver (30) electrical connection lifting electricity
Machine (2)；Measure circuit board (31) electrical connection electric rotating machine driver (29), electric rotating machine driver (29) electrical connection electric rotating machine
(13)；Measuring circuit board (31) and be provided with input control power supply (26), mensuration circuit board (31) is provided with output and controls on and off switch
(27), output controls on and off switch (27) electrical connection relay (28), and relay (28) connects two groups of 24v batteries respectively, one group
Battery and a road relay connect lifting motor driver (30), another Battery pack and another road relay connection electric rotating machine and drive
Dynamic device (29).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610336505.4A CN106037747B (en) | 2016-06-16 | 2016-06-16 | Muroid toes swelling analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610336505.4A CN106037747B (en) | 2016-06-16 | 2016-06-16 | Muroid toes swelling analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106037747A true CN106037747A (en) | 2016-10-26 |
| CN106037747B CN106037747B (en) | 2018-08-31 |
Family
ID=57176462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610336505.4A Active CN106037747B (en) | 2016-06-16 | 2016-06-16 | Muroid toes swelling analyzer |
Country Status (1)
| Country | Link |
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| CN (1) | CN106037747B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1233863A1 (en) * | 1984-06-27 | 1986-05-30 | Иркутский Государственный Медицинский Институт | Apparatus for measuring volume of rotary movements in knee joint |
| CN201036553Y (en) * | 2007-06-06 | 2008-03-19 | 娄建石 | Experimental device for measuring animal toe swelling |
| CN202437120U (en) * | 2012-01-19 | 2012-09-19 | 德州学院 | Rat paw edema measuring device |
| CN202505353U (en) * | 2011-12-30 | 2012-10-31 | 熊智 | Experiment device for measuring swelling volumes of toes of large and small mice |
| CN103549937A (en) * | 2013-11-07 | 2014-02-05 | 中国医科大学附属第一医院 | Tissue-swelling measurement instrument and control method thereof |
| CN203619532U (en) * | 2013-11-07 | 2014-06-04 | 中国医科大学附属第一医院 | Tissue swelling measuring instrument |
| CN204363956U (en) * | 2014-12-15 | 2015-06-03 | 西北民族大学 | Body surface swelling measuring instrument |
-
2016
- 2016-06-16 CN CN201610336505.4A patent/CN106037747B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1233863A1 (en) * | 1984-06-27 | 1986-05-30 | Иркутский Государственный Медицинский Институт | Apparatus for measuring volume of rotary movements in knee joint |
| CN201036553Y (en) * | 2007-06-06 | 2008-03-19 | 娄建石 | Experimental device for measuring animal toe swelling |
| CN202505353U (en) * | 2011-12-30 | 2012-10-31 | 熊智 | Experiment device for measuring swelling volumes of toes of large and small mice |
| CN202437120U (en) * | 2012-01-19 | 2012-09-19 | 德州学院 | Rat paw edema measuring device |
| CN103549937A (en) * | 2013-11-07 | 2014-02-05 | 中国医科大学附属第一医院 | Tissue-swelling measurement instrument and control method thereof |
| CN203619532U (en) * | 2013-11-07 | 2014-06-04 | 中国医科大学附属第一医院 | Tissue swelling measuring instrument |
| CN204363956U (en) * | 2014-12-15 | 2015-06-03 | 西北民族大学 | Body surface swelling measuring instrument |
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| Publication number | Publication date |
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| CN106037747B (en) | 2018-08-31 |
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