CN106036830A - New usage of compound with green plum extract - Google Patents
New usage of compound with green plum extract Download PDFInfo
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- CN106036830A CN106036830A CN201610362691.9A CN201610362691A CN106036830A CN 106036830 A CN106036830 A CN 106036830A CN 201610362691 A CN201610362691 A CN 201610362691A CN 106036830 A CN106036830 A CN 106036830A
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/481—Astragalus (milkvetch)
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of health-care products, and relates to a new usage of a compound with a green plum extract; and the invention especially relates to the usage of the compound with the green plum extract in preparation of health-care products for preventing cardio-cerebrovascular diseases. The compound with the green plum extract is prepared form the following raw materials: a green plum extract, eggplants, astragalus roots, red beans, kudzu-vine roots and celeries. The compound with the green plum extract provided by the invention is rationally and scientifically matched, so that the components can synergistically act to effectively improve content changes of TC, TG, MDA, HDL-C and T-AOC in the serum so as to improve lipid metabolism, prevent atherosclerosis formation as well as obviously prevent and improve the cardio-cerebrovascular diseases. Moreover, the compound with the green plum extract provided by the invention has the advantages of wide raw material sources, low preparation cost, stable product properties, strong direction and so on.
Description
Technical field
The invention belongs to field of health care products, relate to the new application of the compositions containing plum extract, be specifically related to containing
The compositions of plum extract purposes in preparation prevention cardiovascular and cerebrovascular disease health product.
Background technology
In recent years, along with improving constantly of socioeconomic development and living standards of the people, China the most gradually steps into
Aging society, the incidence rate of person in middle and old age's cardiovascular and cerebrovascular disease substantially increases.
Studying display at present, the reason complexity causing cardiovascular and cerebrovascular disease is various.Thrombosis, the exception of lipid metabolism,
The generation of oxygen-derived free radicals, it is all the common common cause causing cardiovascular and cerebrovascular disease that microcirculation is obstructed etc..Additionally, the age because of
Element, and Inheritance etc. all can produce a certain degree of impact.Cardiovascular and cerebrovascular disease has a strong impact on the health of middle-aged and elderly people and is good for
Health and quality of life.Such as heart disease can cause cardio-cerebral syndrome, and apoplexy can cause cerebrocardiac syndrome, cardiovascular and cerebrovascular vessel
Disease often influences each other, and jointly occurs.At present, China because of cardiovascular disease, the number of death is about 2,600,000, about every year
Account for the 45% of total death rate.Due to course of disease length, therapeutic process length, the more high factor for the treatment of cost, cause to society and family
The biggest burden, therefore, finds new potential compositions and prevents cardiovascular and cerebrovascular disease particularly critical.
Chinese patent application 200510052025.7 discloses (20S,24R)-Epoxydammarane-3beta,25-diol in preparation treatment or prevention cardiovascular and cerebrovascular vessel
Application in the medicine of disease, specifically provides its application in the medicine of preparation treatment or prevention myocardial ischemia and it is in system
Application in standby treatment or prevention congestive heart failure medicine.Its anthropomorphic soap unit of joining announced has one to cardiovascular and cerebrovascular disease
Fixed preventive effect, but the complicated process of preparation of described (20S,24R)-Epoxydammarane-3beta,25-diol, relatively costly.
Chinese patent application 201510496281.9, discloses a kind of pharmaceutical preparation treating cardiovascular and cerebrovascular disease, described
Pharmaceutical preparation by Radix Aconiti Lateralis Preparata, Fructus Corni, parching to brown stilbene, Radix Ginseng Rubra, Cortex Cinnamomi, Rhizoma Zingiberis, blood succinum, Radix Glycyrrhizae Preparata, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, raw
Os Draconis, Concha Ostreae, Magnetitum, Caulis Clematidis Armandii, the Radix Aucklandiae, Rhizoma Anemones Altaicae, Radix Polygalae, the Radix Paeoniae Alba is prepared from；Medicine system described in long-term taking
Agent has obvious inhibition thrombosis and Antianginal effect, and treatment cardiovascular and cerebrovascular disease is achieved good effect.But
The raw material type of described pharmaceutical preparation is various, and wherein part medical material is famous and precious and source rareness, such as blood succinum and Cornu Cervi Pantotrichum etc.,
With high costs, narrow application range.
Summary of the invention
It is an object of the invention to overcome weak point of the prior art, it is provided that the compositions containing plum extract new
Purposes, specifically, it is provided that the purposes in preparation prevention cardiovascular and cerebrovascular disease health product of the compositions containing plum extract.This
The compositions compatibility science containing plum extract that invention provides, each component synergism can be effectively improved lipid metabolism, in advance
Anti-atherogenesis, has significantly prevention and improvement result to cardiovascular and cerebrovascular disease.Meanwhile, what the present invention provided contains
The advantages such as it is wide that the compositions having plum extract has raw material sources, and preparation cost is low, and product property is stable and with strong points.
Technical scheme is as follows:
The compositions containing plum extract purposes in preparation prevention cardiovascular and cerebrovascular disease health product, described containing green grass or young crops
The compositions of prunus mume extract includes preparing raw material and parts by weight thereof as follows:
Plum extract 25-35 part, Fructus Solani melongenae 6-12 part, Radix Astragali 6-12 part, Semen Phaseoli 5-10 part, Radix Puerariae 3-5 part and Herba Apii graveolentis 2-4
Part.
Further, the described compositions containing plum extract includes preparing raw material and parts by weight thereof as follows:
Plum extract 30 parts, Fructus Solani melongenae 8 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 4 parts and Herba Apii graveolentis 3 parts.
Further, the preparation method of described plum extract comprises the steps: to clean Armeniaca mume Sieb., after peeling enucleation,
The puree of particle diameter 1～4mm is broken into, with the ethanol that volume fraction is 85% by the ratio of solid-liquid ratio 1: 5 (g/mL) with tissue mashing machine
Example is mechanical shaking extraction 3h at 40 DEG C, filters, repeats to extract 2 times, merging filtrate, and filtrate decompression is distilled off ethanol, 5000g condition
Under be centrifuged sucking filtration after 20min-30min, filtrate is concentrated into the 1/6-1/8 of original volume, obtains plum extract.
The present invention also provides for the preparation method of a kind of compositions containing plum extract, comprises the following steps:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, and the puree breaking into particle diameter 1～4mm with tissue mashing machine, by volume fraction be
The ethanol of 85%, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merges filter
Liquid, filtrate decompression is distilled off ethanol, and sucking filtration after centrifugal 20min-30min under the conditions of 5000g, filtrate is concentrated into the 1/ of original volume
6-1/8, obtains plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, adds the ethanol of its weight 8-10 times, under conditions of temperature is 40-50 DEG C
Ultrasonic extraction 40-50min, extracts 2-4 time, filters, merging filtrate, and filtrate decompression is distilled off ethanol, centrifugal under the conditions of 5000g
Take supernatant after 20min-30min, by the 1/8-1/10 of supernatant concentration to original volume, obtain filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,40～50 DEG C of dry 60-90min, are ground into 30-60 mesh medicine with pulverizer
Powder；
Fructus Solani melongenae is cut into small pieces by S5, and 60～80 DEG C are dried 60～90min, are ground into 45-70 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 5-8 times, in temperature
For ultrasonic extraction 60-90min under conditions of 60-80 DEG C, extract 4-5 time, filter, merging filtrate, centrifugal under the conditions of 5000g
Sucking filtration after 20min-30min, filtrate is concentrated into the 1/4-1/6 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor, adds
Clarifier, stands 3-5h, filters, bottling, gland, and sterilizing to obtain final product.
Further, the described compositions containing plum extract includes preparing raw material and parts by weight thereof as follows:
Plum extract 25-35 part, Fructus Solani melongenae 6-12 part, Radix Astragali 6-12 part, Semen Phaseoli 5-10 part, Radix Puerariae 3-5 part and Herba Apii graveolentis 2-4
Part.
Further, the volume fraction of ethanol used by described step S2 is 50%-60%.
Further, the ultrasonic power in described step S2 is 400-800W.
Further, the ultrasonic power in described step S6 is 900-1000W.
Further, it is characterised in that the pH value regulating mixed liquor in described step S7 is 5.0-6.0.
Further, it is characterised in that in described step S7, clarifier is oligochitosan, its consumption is 0.4-0.6g/L.
Plum extract in the compositions containing plum extract that the present invention provides contains abundant polyphenols
And a small amount of organic acid, there is removing blood vessel free radical and antilithic effect；Fructus Solani melongenae contains abundant solanine and has cool
Blood dissipates effect of blood, and the Citrin that Fructus Solani melongenae contains simultaneously has and improves the microcirculatory effect of body；Selenium element abundant in the Radix Astragali
Can improve the activity of glutathion peroxidase in body cell, improve lipid metabolism, it is multiple that prevention of arterial is atherosis etc.
The generation of cardiovascular disease；Semen Phaseoli also has significant antioxidant activity, improves the metabolism of body；Main effective of Radix Puerariae
Composition is Radix Puerariae isoflavone, has coronary artery dilator and cerebrovascular, reduces myocardial oxygen consumption, improves blood circulation, strengthens machine
Body immunity, reduces the multiple medicinal functions such as blood sugar content；Apigenin (also known as 4',5,7-trihydroxyflavone) abundant in Herba Apii graveolentis is naturally-occurring
A kind of flavone compound, there is the various biological effects such as antiinflammatory, blood pressure lowering, antiallergic.The present invention contains plum extract
Compositions compatibility scientific and reasonable, each component synergism can be effectively improved lipid metabolism, formation that prevention of arterial is atherosis, right
Cardiovascular and cerebrovascular disease has significantly prevention and improvement result, can be used for preparation prevention cardiovascular and cerebrovascular disease health product.
Compared with prior art, the compositions containing plum extract that the present invention provides is used for preventing cardiovascular and cerebrovascular disease to have
There is a following advantage:
(1) composition component containing plum extract that the present invention provides is simple, and preparation method is simple, low cost
Honest and clean；
(2) the compositions compatibility science containing plum extract that the present invention provides, each component synergism can effectively change
Kind lipid metabolism, formation that prevention of arterial is atherosis, cardiovascular and cerebrovascular disease is had significantly prevention and improvement result, the suitability
Extensively；
(3) the compositions stability containing plum extract that the present invention provides is strong, and long-term placement is unlikely to deteriorate.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves, but without departing from this
The basic thought of invention, the most within the scope of the present invention.
The preparation of the embodiment 1 compositions containing plum extract
Include the raw material of preparing of following parts by weight containing the compositions of plum extract described in the embodiment of the present invention 1:
Plum extract 25 parts, Fructus Solani melongenae 6 parts, the Radix Astragali 6 parts, 5 parts of Semen Phaseoli, Radix Puerariae 3 parts and Herba Apii graveolentis 2 parts.
Preparation method is as follows:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, breaks into the puree of particle diameter 1mm with tissue mashing machine, by volume fraction is
The ethanol of 85%, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merges filter
Liquid, filtrate decompression is distilled off ethanol, and sucking filtration after centrifugal 20min under the conditions of 5000g, filtrate is concentrated into the 1/6 of original volume, to obtain final product
Plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, adds the ethanol that volume fraction is 50% of its weight 8 times, is 40 in temperature
DEG C, ultrasonic power is ultrasonic extraction 40min under conditions of 400W, extracts 2 times, filters, and merging filtrate, filtrate decompression is distilled off
Ethanol, takes supernatant after centrifugal 20min under the conditions of 5000g, by the 1/8 of supernatant concentration to original volume, obtains filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,40 DEG C of dry 60min, are ground into 30 mesh medicated powder with pulverizer；
Fructus Solani melongenae is cut into small pieces by S5,60 DEG C of dry 60min, is ground into 45 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 5 times, in temperature is
60 DEG C, ultrasonic power is ultrasonic extraction 60min under conditions of 900W, extracts 4 times, filter, merging filtrate, under the conditions of 5000g from
Sucking filtration after heart 20min, filtrate is concentrated into the 1/4 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor is
5.0, add the oligochitosan of 0.4g/L, stand 3h, filter, bottling, gland, sterilizing, to obtain final product.
The preparation of the embodiment 2 compositions containing plum extract
Include the raw material of preparing of following parts by weight containing the compositions of plum extract described in the embodiment of the present invention 2:
Plum extract 35 parts, Fructus Solani melongenae 12 parts, the Radix Astragali 12 parts, 10 parts of Semen Phaseoli, Radix Puerariae 5 parts and Herba Apii graveolentis 4 parts.
Preparation method is as follows:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, breaks into the puree of particle diameter 4mm with tissue mashing machine, by volume fraction is
The ethanol of 85%, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merges filter
Liquid, filtrate decompression is distilled off ethanol, and sucking filtration after centrifugal 30min under the conditions of 5000g, filtrate is concentrated into the 1/8 of original volume, to obtain final product
Plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, and the volume fraction adding its weight 10 times is 60% ethanol, is 50 in temperature
DEG C, ultrasonic power is ultrasonic extraction 50min under conditions of 800W, extracts 4 times, filters, and merging filtrate, filtrate decompression is distilled off
Ethanol, takes supernatant after centrifugal 30min under the conditions of 5000g, by the 1/10 of supernatant concentration to original volume, obtains filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,50 DEG C of dry 90min, are ground into 60 mesh medicated powder with pulverizer；
Fructus Solani melongenae is cut into small pieces by S5,80 DEG C of dry 90min, is ground into 70 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 8 times, in temperature is
80 DEG C, ultrasonic power is ultrasonic extraction 90min under conditions of 1000W, extracts 5 times, filter, merging filtrate, under the conditions of 5000g from
Sucking filtration after heart 30min, filtrate is concentrated into the 1/6 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor is
6.0, add the oligochitosan of 0.6g/L, stand 5h, filter, bottling, gland, sterilizing, to obtain final product
The preparation of the embodiment 3 compositions containing plum extract
Include the raw material of preparing of following parts by weight containing the compositions of plum extract described in the embodiment of the present invention 3:
Plum extract 30 parts, Fructus Solani melongenae 8 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 4 parts and Herba Apii graveolentis 3 parts.
Preparation method is as follows:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, breaks into the puree of particle diameter 3mm with tissue mashing machine, by volume fraction is
The ethanol of 85%, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merges filter
Liquid, filtrate decompression is distilled off ethanol, and sucking filtration after centrifugal 25min under the conditions of 5000g, filtrate is concentrated into the 1/8 of original volume, to obtain final product
Plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, and the volume fraction adding its weight 9 times is 60% ethanol, is 45 DEG C in temperature,
Ultrasonic power is ultrasonic extraction 45min under conditions of 600W, extracts 3 times, filters, and merging filtrate, filtrate decompression is distilled off second
Alcohol, takes supernatant after centrifugal 25min under the conditions of 5000g, by the 1/8 of supernatant concentration to original volume, obtains filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,40 DEG C of dry 80min, are ground into 60 mesh medicated powder with pulverizer；
Fructus Solani melongenae is cut into small pieces by S5,60 DEG C of dry 70min, is ground into 60 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 7 times, in temperature is
70 DEG C, ultrasonic power is ultrasonic extraction 70min under conditions of 1000W, extracts 4 times, filter, merging filtrate, under the conditions of 5000g from
Sucking filtration after heart 25min, filtrate is concentrated into the 1/5 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor is
5.0, add the oligochitosan of 0.5g/L, stand 5h, filter, bottling, gland, sterilizing, to obtain final product
The preparation of the embodiment 4 compositions containing plum extract
Include the raw material of preparing of following parts by weight containing the compositions of plum extract described in the embodiment of the present invention 4:
Plum extract 30 parts, Fructus Solani melongenae 9 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 4 parts and Herba Apii graveolentis 3 parts.
Preparation method is as follows:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, breaks into the puree of particle diameter 1mm with tissue mashing machine, by volume fraction is
The ethanol of 85%, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merges filter
Liquid, filtrate decompression is distilled off ethanol, and sucking filtration after centrifugal 30min under the conditions of 5000g, filtrate is concentrated into the 1/8 of original volume, to obtain final product
Plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, and the volume fraction adding its weight 9 times is 50% ethanol, is 50 DEG C in temperature,
Ultrasonic power is ultrasonic extraction 45min under conditions of 600W, extracts 3 times, filters, and merging filtrate, filtrate decompression is distilled off second
Alcohol, takes supernatant after centrifugal 25min under the conditions of 5000g, by the 1/8 of supernatant concentration to original volume, obtains filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,40 DEG C of dry 70min, are ground into 60 mesh medicated powder with pulverizer；
Fructus Solani melongenae is cut into small pieces by S5,60 DEG C of dry 60min, is ground into 60 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 6 times, in temperature is
75 DEG C, ultrasonic power is ultrasonic extraction 60min under conditions of 1000W, extracts 4 times, filter, merging filtrate, under the conditions of 5000g from
Sucking filtration after heart 30min, filtrate is concentrated into the 1/4 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor is
5.5, add the oligochitosan of 0.6g/L, stand 5h, filter, bottling, gland, sterilizing, to obtain final product
Comparative example 1
Raw material is prepared containing what the compositions of plum extract included following parts by weight described in comparative example 1
Radix Glycyrrhizae extract 30 parts, Fructus Solani melongenae 8 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 4 parts and Herba Apii graveolentis 3 parts.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, Radix Glycyrrhizae extract be instead of plum extract.
Comparative example 2
Raw material is prepared containing what the compositions of plum extract included following parts by weight described in comparative example 2
Plum extract 30 parts, Fructus Solani melongenae 8 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 7 parts.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, adds the number of Radix Puerariae, does not add Herba Apii graveolentis.
Test example one: the present invention contains the functional evaluation of the compositions prevention cardiovascular and cerebrovascular disease of plum extract
1. subjects: SD healthy rat, male and female half and half, body weight 190 ± 5g, raises in Ji'nan University's experiment dynamic by 108
Thing center.Experimentation is all carried out according to zoopery administrative provisions.108 rats are randomly divided into 9 groups, and one of which is just
Often matched group, other are experimental group, and experiment component is model control group, positive controls, embodiment 1 group, embodiment 2 groups, real
Execute example 3 groups, embodiment 4 groups, comparative example 1 group and comparative example 2 groups, often group 12.
2. test material: embodiment 1-4, the compositions containing plum extract prepared by comparative example 1-2；
Positive controls soup minister is good for fish oil soft capsule again, and (the strong word G20070413 of state's food, cantonese soup minister is good for biotechnology again
Limited company), go capsule shells to take content and add water and be made into the solution of 0.5g/mL.
3. test method: each group of rat is raised and gavage by below scheme:
Normal group: feed normal feedstuff, and press 2.5mL/kg gavage normal saline once a day, continuous gavage 6 weeks；
Model control group: feed high lipid food, and press 2.5mL/kg gavage normal saline once a day, continuous gavage 6 weeks；
Positive controls: feed high lipid food, and be good for again in fish oil soft capsule by 2.5mL/kg gavage soup minister once a day
Tolerant solution, continuous gavage five weeks；
Embodiment 1 group: feed high lipid food, and by the 2.5mL/kg compositions that gavage embodiment 1 obtains once a day, even
Continuous gavage 6 weeks；
Embodiment 2 groups: feed high lipid food, and by the 2.5mL/kg compositions that gavage embodiment 2 obtains once a day, even
Continuous gavage 6 weeks；
Embodiment 3 groups: feed high lipid food, and by the 2.5mL/kg compositions that gavage embodiment 3 obtains once a day, even
Continuous gavage 6 weeks；
Embodiment 4 groups: feed high lipid food, and by the 2.5mL/kg compositions that gavage embodiment 4 obtains once a day, even
Continuous gavage 6 weeks；
Comparative example 1 group: feed high lipid food, and by the 2.5mL/kg compositions that gavage comparative example 1 obtains once a day, even
Continuous gavage 6 weeks；
Comparative example 2 groups: feed high lipid food, and by the 2.5mL/kg compositions that gavage comparative example 2 obtains once a day, even
Continuous gavage 6 weeks；
High lipid food formula: 68.8% normal feedstuff, 1% cholesterol, 0.2% sodium cholate, 10% Adeps Sus domestica, 10% sucrose,
10% yolk powder.
General's test rat feeding gavage, after 6 weeks, take blood in the eye socket corner of the eyes after fasting 12h, in 4 DEG C after blood standing,
3000r/min is centrifuged 15min, takes serum sample test kit cholesterol detection (TC), triglyceride (TG), high density lipoprotein
Cholesterol (HDL-C), malonaldehyde (MDA), total antioxidant capacity (T-AOC) index changes, and it is solid to calculate low density lipoprotein, LDL gallbladder
Alcohol (LDL-C), computing formula is:
Low-density lipoprotein cholesterol (LDL-C)=TC-HDL-C-TG/2.2 (mmol/L).
4. statistical analysis
Experimental result uses SPSS 19.0 software system statistical analysis, and measurement data represents with mean+SD.
5. experimental result: be shown in Table 1.
Table 1 present invention contains the impact on each experimental group SD rat blood serum index of the compositions of plum extract
Note: compare with Normal group,*P ＜ 0.05,**P ＜ 0.01；Compare with model control group,#P ＜ 0.05,##P ＜
0.01；Compare with positive controls,ΔP ＜ 0.05.
Modern medicine study shows, lipid metabolism is closely related with cardiovascular and cerebrovascular disease, and it is to form tremulous pulse that TC and TG raises
Atherosis, cause the key factor of cardiovascular and cerebrovascular disease；HDL-C is a kind of antiatherogenic lipoprotein, and LDL-C is
Evaluating an important indicator of the individual pathogenetic risk factor of coronary disease, the height of MDA can be as body lipid peroxidation journey
The evaluation of degree characterizes, and the height of T-AOC can reflect the power of body defenses system oxidation resistance, therefore, each by measuring
Administration group, Normal group and model control group Serum TC, the changes of contents of TG, HDL-C, MDA, T-AOC index is permissible
The function of the present invention compositions prevention cardiovascular and cerebrovascular disease containing plum extract is evaluated.
As shown in Table 1, compared with model control group, TC in various embodiments of the present invention group rat blood serum, the content of TG, MDA
Significantly reducing, in serum, HDL-C and T-AOC content significantly improves, and illustrates that the compositions that the present invention contains plum extract can have
Effect improves lipid metabolism, formation that prevention of arterial is atherosis, has significantly prevention and improvement result to cardiovascular and cerebrovascular disease, its
The effect of middle embodiment 3 groups is the most notable, for highly preferred embodiment of the present invention；And comparative example 1,2 groups respectively refers in rat blood serum
The improvement result of mark content is inconspicuous.
Test example two. the stability test of the present invention compositions containing plum extract
1. test material: embodiment 1, embodiment 2, embodiment 3 and the combination containing plum extract of embodiment 4 preparation
Thing.
2. test method:
Former with the guidance of pharmaceutical preparation stability test with reference to the annex XIXC crude drug of " Chinese Pharmacopoeia 2010 version two "
Then test material is carried out long term test, investigate its outward appearance, color and luster and abnormal smells from the patient.
3. result of the test: result of the test is as shown in the table:
The result of the long term test of the table 2 compositions containing plum extract
As shown in Table 2, the compositions containing plum extract that prepared by embodiment of the present invention 1-4 temperature be 25 DEG C ± 2 DEG C,
Relative humidity be place 18 months under conditions of 60% ± 10% after still clarification, glossy, illustrate prepared by the present invention containing blue or green
The compositions of prunus mume extract has higher stability, and the sense organ that can effectively improve the compositions containing plum extract refers to
Mark, is conducive to long-term preservation.
Claims (10)
1. the compositions containing plum extract is preparing the purposes prevented in cardiovascular and cerebrovascular disease health product, it is characterised in that
The described compositions containing plum extract includes preparing raw material and parts by weight thereof as follows:
Plum extract 25-35 part, Fructus Solani melongenae 6-12 part, Radix Astragali 6-12 part, Semen Phaseoli 5-10 part, Radix Puerariae 3-5 part and Herba Apii graveolentis 2-4 part.
2. purposes as claimed in claim 1, it is characterised in that the described compositions containing plum extract includes preparing as follows
Raw material and parts by weight thereof:
Plum extract 30 parts, Fructus Solani melongenae 8 parts, the Radix Astragali 9 parts, 8 parts of Semen Phaseoli, Radix Puerariae 4 parts and Herba Apii graveolentis 3 parts.
3. purposes as claimed in claim 1 or 2, it is characterised in that the preparation method of described plum extract includes walking as follows
Rapid: Armeniaca mume Sieb. is cleaned, after peeling enucleation, break into the puree of particle diameter 1～4mm with tissue mashing machine, be 85% by volume fraction
Ethanol, in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filters, repeats to extract 2 times, merging filtrate, filtrate
Decompression is distilled off ethanol, sucking filtration after centrifugal 20min-30min under the conditions of 5000g, and filtrate is concentrated into the 1/6-1/8 of original volume,
Obtain plum extract.
4. the preparation method of the compositions containing plum extract, it is characterised in that comprise the following steps:
Armeniaca mume Sieb. is cleaned by S1, after peeling enucleation, breaks into the puree of particle diameter 1～4mm with tissue mashing machine, is 85% by volume fraction
Ethanol in ratio mechanical shaking extraction 3h at 40 DEG C of solid-liquid ratio 1: 5 (g/mL), filter, repeat to extract 2 times, merging filtrate, filter
Liquid decompression is distilled off ethanol, and sucking filtration after centrifugal 20min-30min under the conditions of 5000g, filtrate is concentrated into the 1/6-1/ of original volume
8, obtain plum extract；
Herba Apii graveolentis is cleaned by S2, is cut into segment, adds the ethanol of its weight 8-10 times, temperature be under conditions of 40-50 DEG C ultrasonic
Extraction 40-50min, extracts 2-4 time, filters, merging filtrate, and filtrate decompression is distilled off ethanol, centrifugal under the conditions of 5000g
Take supernatant after 20min-30min, by the 1/8-1/10 of supernatant concentration to original volume, obtain filtrate I；
Plum extract is mixed by S3 with filtrate I, obtains solution II；
Semen Phaseoli, the Radix Astragali and Radix Puerariae are cleaned by S4,40～50 DEG C of dry 60-90min, are ground into 30-60 mesh medicated powder with pulverizer；
Fructus Solani melongenae is cut into small pieces by S5, and 60～80 DEG C are dried 60～90min, are ground into 45-70 mesh medicated powder with pulverizer；
Step S4 is mixed homogeneously by S6 with the medicated powder of step S5, adds the purified water of mixed powder weight 5-8 times, in temperature is
Under conditions of 60-80 DEG C, ultrasonic extraction 60-90min, extracts 4-5 time, filters, merging filtrate, centrifugal 20min-under the conditions of 5000g
Sucking filtration after 30min, filtrate is concentrated into the 1/4-1/6 of original volume, obtains filtrate II I；
S7 mixes by solution II described in S3 with filtrate II I described in S6, with the pH value in citric acid regulation mixed liquor, adds clarification
Agent, stands 3-5h, filters, bottling, gland, and sterilizing to obtain final product.
5. preparation method as claimed in claim 4, it is characterised in that the described compositions containing plum extract includes as follows
Prepare raw material and parts by weight thereof:
Plum extract 25-35 part, Fructus Solani melongenae 6-12 part, Radix Astragali 6-12 part, Semen Phaseoli 5-10 part, Radix Puerariae 3-5 part and Herba Apii graveolentis 2-4 part.
6. preparation method as claimed in claim 4, it is characterised in that used by described step S2, the volume fraction of ethanol is
50%-60%.
7. preparation method as claimed in claim 4, it is characterised in that the ultrasonic power in described step S2 is 400-800W.
8. preparation method as claimed in claim 4, it is characterised in that the ultrasonic power in described step S6 is 900-1000W.
9. preparation method as claimed in claim 4, it is characterised in that the pH value regulating mixed liquor in described step S7 is 5.0-
6.0。
10. preparation method as claimed in claim 4, it is characterised in that in described step S7, clarifier is oligochitosan, its consumption
For 0.4-0.6g/L.
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| CN201610362691.9A CN106036830A (en) | 2016-05-26 | 2016-05-26 | New usage of compound with green plum extract |
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| CN201610362691.9A CN106036830A (en) | 2016-05-26 | 2016-05-26 | New usage of compound with green plum extract |
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ID=57176061
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| CN201610362691.9A Withdrawn CN106036830A (en) | 2016-05-26 | 2016-05-26 | New usage of compound with green plum extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403732A (en) * | 2018-04-28 | 2018-08-17 | 张家港威胜生物医药有限公司 | A kind of industrial process of green plum total extract |
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| CN1257408A (en) * | 1997-04-21 | 2000-06-21 | 维微亚美国交易股份有限公司 | Nutritive composition for cardiovascular health |
| CN101209096A (en) * | 2006-12-31 | 2008-07-02 | 中国科学院过程工程研究所 | Edible porridge and preparation method thereof |
| CN101366530A (en) * | 2008-09-27 | 2009-02-18 | 沈阳麦金利食品制造有限公司 | Process for preparing composite enzyme and product thereof |
| CN101449773A (en) * | 2007-11-28 | 2009-06-10 | 天津市中英保健食品有限公司 | Novel dietotherapy porridge and production technique thereof |
| CN103610200A (en) * | 2013-12-12 | 2014-03-05 | 安徽唐人保健茶品有限公司 | Anticancer health-care oral liquid and preparation method thereof |
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2016
- 2016-05-26 CN CN201610362691.9A patent/CN106036830A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1257408A (en) * | 1997-04-21 | 2000-06-21 | 维微亚美国交易股份有限公司 | Nutritive composition for cardiovascular health |
| CN101209096A (en) * | 2006-12-31 | 2008-07-02 | 中国科学院过程工程研究所 | Edible porridge and preparation method thereof |
| CN101449773A (en) * | 2007-11-28 | 2009-06-10 | 天津市中英保健食品有限公司 | Novel dietotherapy porridge and production technique thereof |
| CN101366530A (en) * | 2008-09-27 | 2009-02-18 | 沈阳麦金利食品制造有限公司 | Process for preparing composite enzyme and product thereof |
| CN103610200A (en) * | 2013-12-12 | 2014-03-05 | 安徽唐人保健茶品有限公司 | Anticancer health-care oral liquid and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108403732A (en) * | 2018-04-28 | 2018-08-17 | 张家港威胜生物医药有限公司 | A kind of industrial process of green plum total extract |
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Application publication date: 20161026 |