CN106031764A - Skin-whitening and chloasma-removing pharmaceutical composition gel and preparation method thereof - Google Patents
Skin-whitening and chloasma-removing pharmaceutical composition gel and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract
The invention relates to skin-whitening and chloasma-removing pharmaceutical composition gel and a preparation method thereof. The traditional Chinese medicine composition gel is composed of traditional Chinese medicine extract and a gel molding agent; the traditional Chinese medicine extract is prepared from, by weight, 4-8 parts of Japanese ampelopsis roots, 5-10 parts of rhizoma atractylodis macrocephalae, 6-8 parts of roots of Yunnan morning glory, 6-12 parts of hydrocharisdubia (BI.) Backer, 8-12 parts of radix angelicae dahuricae, 5-10 parts of herba asari, 6-12 parts of slender dutchmanspipe roots, 6-12 parts of chuanxiong rhizomes, 5-10 parts of apricot kernels, 4-10 parts of milkvetch roots, 6-12 parts of giant typhonium rhizomes, 5-8 parts of coriander seeds and 3-9 parts of bitter melon slices, and the gel molding agent is prepared from deionized water, hyaluronic acid and poloxamer. According to the skin-whitening and chloasma-removing pharmaceutical composition gel and the preparation method thereof, the traditional Chinese medicines such as Japanese ampelopsis roots, rhizoma atractylodis macrocephalae, roots of Yunnan morning glory and hydrocharisdubia (BI.) Backer are reasonably selected, dry powder is obtained through extracting and drying, the traditional Chinese medicines and the gel molding agent are evenly mixed to be gel in proportion when being used, mixing is conducted when using is needed, extremely high pharmaceutical activity is kept, the gel is coated on the surface of the skin, and use is very convenient; due to the gel composition, the water locking property is good, the gel is not prone to volatilize and dry, the pharmaceutical effective ingredients can slowly released for a long time, and the skin-whitening and chloasma-removing effects are good.
Description
Technical field
The present invention relates to a kind of drug gel and preparation method thereof, more particularly to the drug regimen of a kind of whitening and speckle dispelling
Thing gel and preparation method thereof.
Background technology
Chloasma occurs mainly in face, based on cheekbone portion, buccal, nose, forehead, chin portion, for the brown of obscure boundary Chu
Or the patch of black, it mostly is symmetry.The appearance of chloasma is most relevant with endocrine, especially with the estrogen level of women
Relevant, menoxenia, gestation, take contraceptive or liver function is bad and chronic nephropathy is all likely to occur chloasma.In addition Exposure to Sunlight
Also primary disease can be increased the weight of with Nervous and Mental Factors.Chinese medicine is thought, the generation of chloasma is many due to deficiency of kidney yin, kidney water can not on hold, or
Stagnation of liver-QI is depressed, liver is lost bar and reaches, strongly fragrant long heat-transformation, and cloudy blood of burning causes face qi-blood disharmony and falls ill.Patient with chloasma is normal clinically
The card of the deficiency of kidney yin such as menoxenia, soreness of the waist and knees occurs, or shows the irritabilities such as depressed, feelings will not smooth, the being irritable and getting angry easily of personality
Do not relax symptom.The reason that chloasma occurs has a lot, and its definite cause of disease is not fully understood at present.The product of auxiliary treatment at present
The effect of chloasma is all not so good, and the especially Chinese medicine of the treatment chloasma of gel-like is urgently developed.
Summary of the invention
It is an object of the invention to solve the deficiencies in the prior art, it is provided that the pharmaceutical composition gel of a kind of whitening and speckle dispelling.
Further object is that the preparation method of the pharmaceutical composition gel that a kind of whitening and speckle dispelling is provided.
The technical solution adopted for the present invention to solve the technical problems is:
The pharmaceutical composition gel of whitening and speckle dispelling, described Chinese medicine composition gel is made up of Chinese medicine extract and gel forming agent,
Described Chinese medicine extract is processed by the Chinese medicine of following weight portion: Radix Ampelopsis 4-8 part, Rhizoma Atractylodis Macrocephalae 5-10 part, soil melon root 6-8 part, another name for Sichuan Province
Spray 6-12 part, Radix Angelicae Dahuricae 8-12 part, Herba Asari 5-10 part, Radix Aristolochiae 6-12 part, Rhizoma Chuanxiong 6-12 part, Semen Armeniacae Amarum 5-10 part, Radix Astragali 4-10
Part, Rhizoma Typhonii 6-12 part, caraway seeds 5-8 part, Fructus Momordicae charantiae slice 3-9 part, described gel forming agent is by deionized water, hyaluronic acid and pool
Luo Shamu forms, and medicament and gel forming agent separately store, with suitable ratio mix homogeneously both during use.
Rational choice of the present invention Radix Ampelopsis, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Huang
Stilbene, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, obtain dry powder by extraction, concentration, lyophilization, individually seal up for safekeeping, prevented from caking, have
Effect composition is difficult to oxidation deterioration, long shelf-life, mixes in proportion into gel with gel forming agent during use, existing mixed existing use,
Keep high pharmaceutically active, be coated on skin surface, very easy to use, owing in gel, lock aqueous is good, the most volatile
Becoming dry, effective ingredient can the most slowly discharge, and whitening and speckle dispelling is effective.
Wherein caraway seeds containing volatile oil, malic acid, potassium salt, organic acid calcium salt, fat, protein, multivitamin and
Nitrogen substance, can improve the surface of skin, can be with purifying skin, containing malignant cell generation and enhancing can be suppressed to exempt from Fructus Momordicae charantiae
The protease of epidemic disease cytoactive, it is possible to stop growth and the diffusion of malignant cell, there is obvious antiinflammatory effect of dispelling spots.
Preferably, described Chinese medicine extract is processed by following weight portion Chinese medicine: Radix Ampelopsis 6 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, soil melon root
7 parts, another name for Sichuan Province spray 10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Asari 8 parts, Radix Aristolochiae 8 parts, Rhizoma Chuanxiong 8 parts, 6 parts of Semen Armeniacae Amarum, the Radix Astragali 6 parts, Rhizoma Typhonii 8 parts,
Caraway seeds 6 parts, Fructus Momordicae charantiae slice 5 parts.
Preferably, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.2-0.4%, poloxamer
18-24%, surplus is deionized water.
Preferably, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.3%, and poloxamer 20% is remaining
Amount is deionized water.
Preferably, the proportioning of described Chinese medicine extract and gel forming agent is as follows: every 30-40g Chinese medicine extract joins 80-
100ml gel forming agent, the two is uniformly mixed under room temperature.
A kind of preparation method of the pharmaceutical composition gel of whitening and speckle dispelling:
A () prepares Chinese medicine extract: the Radix Ampelopsis of formula ratio, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong,
Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, add the ethanol water of 150 ~ 200ml volume fraction 70-80%, in 90-
110 DEG C of backflows extract 2-3 hour, and lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, so
Rear micro-filtration goes the removal of impurity, encapsulation；
Chinese medicine extract and gel forming agent separately store, and with suitable ratio mix homogeneously both during use, hybrid mode is
Chinese medicine extract adds in gel forming agent, stirring while adding.
The invention has the beneficial effects as follows: Rational choice of the present invention Radix Ampelopsis, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari,
Radix Aristolochiae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, obtain dry powder by extraction, concentration, lyophilization, single
Solely sealing up for safekeeping, prevented from caking, effective ingredient is difficult to oxidation deterioration, long shelf-life, is mixed in proportion all with gel forming agent during use
Even one-tenth gel, existing mixed existing use, keep high pharmaceutically active, be coated on skin surface, very easy to use, due in gel
Shape, lock aqueous is good, and the most volatile exsiccation, effective ingredient can the most slowly discharge, and whitening and speckle dispelling is effective.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in further detail.
Embodiment 1:
The pharmaceutical composition gel of whitening and speckle dispelling, described Chinese medicine composition gel is made up of Chinese medicine extract and gel forming agent,
Described Chinese medicine extract is processed by the Chinese medicine of following weight portion: Radix Ampelopsis 4 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, soil melon root 6 parts, another name for Sichuan Province spray 6
Part, the Radix Angelicae Dahuricae 8 parts, Herba Asari 5 parts, Radix Aristolochiae 6 parts, Rhizoma Chuanxiong 6 parts, 5 parts of Semen Armeniacae Amarum, the Radix Astragali 4 parts, Rhizoma Typhonii 6 parts, caraway seeds 5 parts, Fructus Momordicae charantiae
Sheet 3 parts, described gel forming agent is made up of deionized water, hyaluronic acid and poloxamer, medicament and gel forming agent separately storage
Deposit, with suitable ratio mix homogeneously both during use；The percentage by weight composition of described gel forming agent is as follows: hyaluronic acid
0.2%, poloxamer 18%, surplus is deionized water；
The preparation method of the pharmaceutical composition gel of described whitening and speckle dispelling:
A () prepares Chinese medicine extract: the Radix Ampelopsis of formula ratio, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong,
Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, add the ethanol water of 150ml volume fraction 80%, in 110 DEG C of backflows
Extracting 2 hours, lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, so
Rear micro-filtration goes the removal of impurity, encapsulation；
Chinese medicine extract and gel forming agent separately store, and with suitable ratio mix homogeneously both during use, hybrid mode is
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 30g Chinese medicine extract joins 80ml gel forming agent.
Embodiment 2:
The pharmaceutical composition gel of a kind of whitening and speckle dispelling, described Chinese medicine composition gel is by Chinese medicine extract and gel forming agent group
Becoming, described Chinese medicine extract is processed by the Chinese medicine of following weight portion: Radix Ampelopsis 8 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, soil melon root 8 parts, Shu Shui
Spend 12 parts, the Radix Angelicae Dahuricae 12 parts, Herba Asari 10 parts, Radix Aristolochiae 12 parts, Rhizoma Chuanxiong 12 parts, 10 parts of Semen Armeniacae Amarum, the Radix Astragali 10 parts, Rhizoma Typhonii 12 parts is fragrant
Semen Allii Tuberosi 8 parts, Fructus Momordicae charantiae slice 9 parts, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.8%, poloxamer
28%, surplus is deionized water；The percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.4%, poloxamer
24%, surplus is deionized water；
The preparation method of the pharmaceutical composition gel of described whitening and speckle dispelling:
A () prepares Chinese medicine extract: the Radix Ampelopsis of formula ratio, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong,
Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, add the ethanol water of 180ml volume fraction 70%, in 90 DEG C of backflow leachings
Carrying 3 hours, lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, so
Rear micro-filtration goes the removal of impurity, encapsulation；
Chinese medicine extract and gel forming agent separately store, and with suitable ratio mix homogeneously both during use, hybrid mode is
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 40g Chinese medicine extract joins 100ml gel forming agent.
Embodiment 3:
The pharmaceutical composition gel of a kind of whitening and speckle dispelling, described Chinese medicine composition gel is by Chinese medicine extract and gel forming agent group
Becoming, described Chinese medicine extract is processed by the Chinese medicine of following weight portion: Radix Ampelopsis 6 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, soil melon root 7 parts, another name for Sichuan Province spray
10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Asari 8 parts, Radix Aristolochiae 8 parts, Rhizoma Chuanxiong 8 parts, 6 parts of Semen Armeniacae Amarum, the Radix Astragali 6 parts, Rhizoma Typhonii 8 parts, caraway seeds 6 parts,
Fructus Momordicae charantiae slice 5 parts, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.3%, poloxamer 20%, surplus is
Deionized water；
The preparation method of the pharmaceutical composition gel of described whitening and speckle dispelling:
A () prepares Chinese medicine extract: the Radix Ampelopsis of formula ratio, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong,
Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, add the ethanol water of 170ml volume fraction 75%, in 100 DEG C of backflows
Extracting 2.5 hours, lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, so
Rear micro-filtration goes the removal of impurity, encapsulation；
Chinese medicine extract and gel forming agent separately store, and with suitable ratio mix homogeneously both during use, hybrid mode is
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 35g Chinese medicine extract joins 90ml gel forming agent.
Clinical verification
1, identifying object: buccal both sides large area chloasma
2, experimental group: 120 examples, women, age 24～45 years old, average 32 years old, it is randomly divided into three groups,
3, using method: experimental group is respectively coated with the whitening and speckle dispelling Chinese medicine composition gel that embodiment 1-3 prepares, coating
Front cleansing milk face cleaning, every day each 1 time sooner or later, uses 30 days continuously.
4, efficacy determination: effective: chloasma disappears at least 90%；Take a turn for the better: chloasma disappears 60-80%, and symptom has
Greatly improve；Alleviating, chloasma disappears 40-60%, and symptom has improvement；Invalid: chloasma disappears≤40%, symptom is without slow
Solve.
5, result is as follows:
| Effective | Take a turn for the better | Alleviate | Invalid | Total effective rate | |
| Experimental group 1 | 20 | 6 | 6 | 8 | 80% |
| Experimental group 2 | 20 | 10 | 6 | 4 | 90% |
| Experimental group 3 | 25 | 5 | 10 | 0 | 100% |
Rational choice of the present invention Radix Ampelopsis, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, the Radix Astragali,
Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, obtain dry powder by extraction, concentration, lyophilization, individually seal up for safekeeping, prevented from caking, effectively become
Divide and be difficult to oxidation deterioration, long shelf-life, during use, mix in proportion into gel with gel forming agent, existing mixed existing use, keep
High pharmaceutically active, is coated on skin surface, very easy to use, owing in gel, lock aqueous is good, the most volatile change
Dry, effective ingredient can the most slowly discharge, and whitening and speckle dispelling is effective.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma
Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.
Claims (6)
1. the pharmaceutical composition gel of whitening and speckle dispelling, it is characterised in that: described Chinese medicine composition gel is by Chinese medicine extract and coagulates
Gum forming agent forms, and described Chinese medicine extract is processed by the Chinese medicine of following weight portion: Radix Ampelopsis 4-8 part, Rhizoma Atractylodis Macrocephalae 5-10 part,
Soil melon root 6-8 part, another name for Sichuan Province spray 6-12 part, Radix Angelicae Dahuricae 8-12 part, Herba Asari 5-10 part, Radix Aristolochiae 6-12 part, Rhizoma Chuanxiong 6-12 part, Semen Armeniacae Amarum 5-
10 parts, Radix Astragali 4-10 part, Rhizoma Typhonii 6-12 part, caraway seeds 5-8 part, Fructus Momordicae charantiae slice 3-9 part, described gel forming agent is by deionization
Water, hyaluronic acid and poloxamer composition, Chinese medicine extract and gel forming agent separately store, with suitable ratio both during use
Example mix homogeneously.
The pharmaceutical composition gel of whitening and speckle dispelling the most according to claim 1, it is characterised in that: described Chinese medicine extract by
Following weight portion Chinese medicine processes: Radix Ampelopsis 6 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, soil melon root 7 parts, another name for Sichuan Province spray 10 parts, the Radix Angelicae Dahuricae 10 parts, Herba Asari 8
Part, Radix Aristolochiae 8 parts, Rhizoma Chuanxiong 8 parts, 6 parts of Semen Armeniacae Amarum, the Radix Astragali 6 parts, Rhizoma Typhonii 8 parts, caraway seeds 6 parts, Fructus Momordicae charantiae slice 5 parts.
The pharmaceutical composition gel of whitening and speckle dispelling the most according to claim 1, it is characterised in that: described gel forming agent
Percentage by weight composition is as follows: hyaluronic acid 0.2-0.4%, poloxamer 18-24%, surplus is deionized water.
The pharmaceutical composition gel of whitening and speckle dispelling the most according to claim 3, it is characterised in that: described gel forming agent
Percentage by weight composition is as follows: hyaluronic acid 0.3%, poloxamer 20%, surplus is deionized water.
The pharmaceutical composition gel of whitening and speckle dispelling the most according to claim 1, it is characterised in that: described Chinese medicine extract and
The proportioning of gel forming agent is as follows: every 30-40g Chinese medicine extract joins 80-100ml gel forming agent, and the two stirs under room temperature
Mix homogeneously.
6. a preparation method for the pharmaceutical composition gel of the whitening and speckle dispelling described in claim 1-5 any one, its feature
It is:
A () prepares Chinese medicine extract: the Radix Ampelopsis of formula ratio, the Rhizoma Atractylodis Macrocephalae, soil melon root, another name for Sichuan Province spray, the Radix Angelicae Dahuricae, Herba Asari, Radix Aristolochiae, Rhizoma Chuanxiong,
Semen Armeniacae Amarum, the Radix Astragali, Rhizoma Typhonii, caraway seeds and Fructus Momordicae charantiae slice, add the ethanol water of 150 ~ 200ml volume fraction 70-80%, in 90-
110 DEG C of backflows extract 2-3 hour, and lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, so
Rear micro-filtration goes the removal of impurity, encapsulation；
Chinese medicine extract and gel forming agent separately store, and with suitable ratio mix homogeneously both during use, hybrid mode is
Chinese medicine extract adds in gel forming agent, stirring while adding.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331128A (en) * | 2018-12-17 | 2019-02-15 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating color spot type skin |
| CN109350635A (en) * | 2018-12-13 | 2019-02-19 | 杨俊涛 | A kind of gelling agent and preparation method and preparation facilities for acne |
| CN112656916A (en) * | 2020-12-29 | 2021-04-16 | 管晓坤 | Traditional Chinese medicine gel with whitening and freckle removing effects and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083401A (en) * | 1992-09-03 | 1994-03-09 | 王皓 | Ion skin-care beautifying electric water heater electrode and preparation method thereof |
| CN1105560A (en) * | 1994-10-13 | 1995-07-26 | 赖晓梅 | Paper beautifying face mask and its preparing method thereof |
| CN1125577A (en) * | 1994-12-19 | 1996-07-03 | 李兴行 | Cosmetic medicine and its preparation method |
| CN1943683A (en) * | 2005-10-08 | 2007-04-11 | 曾雄辉 | An external use medicinel and beauty composition for treatment of and preventing chloasma |
| CN101411680A (en) * | 2007-10-15 | 2009-04-22 | 赵伟 | Method for preparing seven-white paste for cleaning face |
| CN103610926A (en) * | 2013-11-27 | 2014-03-05 | 成都大医精诚投资管理有限公司 | Chinese medicinal anti-freckle composition, Chinese medicinal anti-freckle preparation and Chinese medicinal anti-freckle mask |
| CN105534739A (en) * | 2015-12-31 | 2016-05-04 | 杭州惠康医疗器械有限公司 | Plural gel |
-
2016
- 2016-05-19 CN CN201610334024.XA patent/CN106031764A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083401A (en) * | 1992-09-03 | 1994-03-09 | 王皓 | Ion skin-care beautifying electric water heater electrode and preparation method thereof |
| CN1105560A (en) * | 1994-10-13 | 1995-07-26 | 赖晓梅 | Paper beautifying face mask and its preparing method thereof |
| CN1125577A (en) * | 1994-12-19 | 1996-07-03 | 李兴行 | Cosmetic medicine and its preparation method |
| CN1943683A (en) * | 2005-10-08 | 2007-04-11 | 曾雄辉 | An external use medicinel and beauty composition for treatment of and preventing chloasma |
| CN101411680A (en) * | 2007-10-15 | 2009-04-22 | 赵伟 | Method for preparing seven-white paste for cleaning face |
| CN103610926A (en) * | 2013-11-27 | 2014-03-05 | 成都大医精诚投资管理有限公司 | Chinese medicinal anti-freckle composition, Chinese medicinal anti-freckle preparation and Chinese medicinal anti-freckle mask |
| CN105534739A (en) * | 2015-12-31 | 2016-05-04 | 杭州惠康医疗器械有限公司 | Plural gel |
Non-Patent Citations (3)
| Title |
|---|
| 南朝君: "《食疗、营养与烹调》", 31 January 2014, 中国医药科技出版社 * |
| 欧广升: "《慢性病外治妙术》", 30 April 2009, 湖南科学技术出版社 * |
| 西子: "《跟着皇妃学美容——10大皇妃美人计》", 30 June 2012, 西安交通大学出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350635A (en) * | 2018-12-13 | 2019-02-19 | 杨俊涛 | A kind of gelling agent and preparation method and preparation facilities for acne |
| CN109350635B (en) * | 2018-12-13 | 2021-04-06 | 杨俊涛 | Gel for acne, preparation method and preparation device |
| CN109331128A (en) * | 2018-12-17 | 2019-02-15 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating color spot type skin |
| CN112656916A (en) * | 2020-12-29 | 2021-04-16 | 管晓坤 | Traditional Chinese medicine gel with whitening and freckle removing effects and preparation method thereof |
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Address after: 325200 Wenzhou, Ruian, Binjiang Avenue, the new era of the new experimental school, No. 1658 Applicant after: Zhang Shucheng Address before: 325200 Wenzhou, Ruian, Binjiang Avenue, the new era of the new experimental school, No. 1658 Applicant before: Zhang Shucheng |
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Application publication date: 20161019 |