CN105999384A

CN105999384A - Medicinal adhesive using medical high polymer material

Info

Publication number: CN105999384A
Application number: CN201610310582.2A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-07
Filing date: 2014-11-07
Publication date: 2016-10-12
Also published as: CN105920657B; CN104368030A; CN105999385A; CN105903065B; CN105920657A; CN104368030B; CN105903065A; CN105963767A

Abstract

The invention provides a medicinal adhesive using a medical high polymer material. The medicinal adhesive comprises polyacrylate, tragacanth, polymethacrylate, squalane, benzoyl peroxide, rosin glycerin ester, dimethyl sebacate, hydroquinone, p-toluenesulfonic acid, dioctyl phthalate, tricalcium phosphate and sodium alginate. The preparation method of the medicinal adhesive comprises the steps that firstly the polyacrylate, the tragacanth, the polymethacrylate and the squalane are mixed, then the benzoyl peroxide and the rosin glycerin ester are added, and a mixture I is obtained by stirring; the dimethyl sebacate, the hydroquinone, the p-toluenesulfonic acid, the dioctyl phthalate, the tricalcium phosphate and the sodium alginate are mixed, and a mixture II is obtained; the mixture I and the mixture II are mixed and cooled to the room temperature after heating and heat preservation, and the medicinal adhesive is obtained. The medicinal adhesive is moderate in curing speed, long in stable time and high in bonding strength.

Description

Use the adhesive of medical of medical macromolecular materials

Technical field

The invention belongs to medical macromolecular materials technical field, be specifically related to a kind of adhesive of medical and preparation method thereof.

Background technology

Before the use of adhesive of medical can trace back to several century.It is initially and obtains from the skin of animal, tendon, cartilage Animal glue.Roman is about at B.C. 3000, and Egypt employs the mixture of referred to as adhesive of medical first, ancient later Greek is prepared for medical plaster shape mixture with olive oil, lead oxide and water.1845, one of first batch of patent just authorized conduct The natural rubber pressure sensitive glue of surgery splicing tape application.Within 1936, German Ku lzeer Co company i.e. has with methyl methacrylate (MMA) be main body dental mesenchymal cells agent sell.Nineteen fifty-nine U.S. Eastman910 fast binder (Mecrilate) asks Generation, it is achieved that surgical operation is by the great revolution stitching, pricking bonding.First by acrylic acid bone cement, (bone bonds nineteen sixty Charnly Agent) succeed in the operation of artificial hip joint.At present, adhesive of medical has evolved into a kind of senior special material, Its different properties, to be adapted to various different purposes.

Adhesive of medical is mainly used in the various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, and it is to people Body biological tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Existing medical adhesive Agent, due to formula imperfection, and generally individually with SO2 as polymerization inhibitor, it is difficult to control consumption so that shaped article is unstable, makes Used time curing rate is undesirable, and bonding strength is inadequate, and, albinism easily occurs during use, big to human body zest, People is made to have burning sensation.

Summary of the invention

It is an object of the invention to overcome the deficiencies in the prior art to provide a kind of adhesive of medical and preparation method thereof, this doctor Moderate with binding agent curing rate, length stabilization time, adhesive strength are strong.

A kind of adhesive of medical, includes: polyacrylate 3～10 parts, tragacanth 2～9 parts, poly-methyl in parts by weight Acrylate 1～7 parts, squalane 2～8 parts, benzoyl peroxide 3～12 parts, glycerol three rosin ester 4～12 parts, decanedioic acid Dimethyl ester 2～9 parts, hydroquinone 1～7 parts, to benzene methanesulfonic acid 3～10 parts, dioctyl phthalate 2～9 parts, tricalcium phosphate 1～7 part, sodium alginate 3～10 parts.

As the further improvement of foregoing invention, described adhesive of medical includes in parts by weight: polyacrylate 4～8 Part, tragacanth 3～7 parts, polymethacrylates 2～6 parts, squalane 3～7 parts, benzoyl peroxide 5～10 parts, glycerol Three rosin esters 6～10 parts, dimethyl sebacate 3～7 parts, hydroquinone 2～6 parts, to benzene methanesulfonic acid 5～9 parts, O-phthalic Dioctyl phthalate 4～7 parts, tricalcium phosphate 2～5 parts, sodium alginate 4～8 parts.

As the further improvement of foregoing invention, described adhesive of medical includes in parts by weight: polyacrylate 7 parts, Tragacanth 5 parts, polymethacrylates 4 parts, squalane 5 parts, benzoyl peroxide 9 parts, glycerol three rosin ester 7 parts, the last of the ten Heavenly stems Acid dimethyl 6 parts, hydroquinone 4 parts, to benzene methanesulfonic acid 7 parts, dioctyl phthalate 6 parts, tricalcium phosphate 3 parts, Sargassum 7 parts of sodium of acid.

The preparation method of above-mentioned adhesive of medical, comprises the following steps:

Step 1, pours in stirred tank by polyacrylate, tragacanth, polymethacrylates and squalane, stirs, Stirred tank is heated to 100～120 DEG C, adds benzoyl peroxide and glycerol three rosin ester, stir, be cooled to room Warm mixture I；

Step 2, by dimethyl sebacate, hydroquinone, to benzene methanesulfonic acid, dioctyl phthalate, tricalcium phosphate and Sargassum Acid sodium is poured in stirred tank, after stirred tank is heated to 80～100 DEG C, is cooled to room temperature and obtains mixture II；

Step 3, mixes mixture I and mixture II, is heated to 70～90 DEG C, after insulation 2～8h, is cooled to room temperature, to obtain final product.

As the further improvement of foregoing invention, in step 1, the vacuum of stirred tank is 0.08～0.1MPa.

As the further improvement of foregoing invention, in step 2, the vacuum of stirred tank is 0.08～0.1MPa.

The adhesive of medical of the present invention, uses benzoyl peroxide and glycerol three rosin ester used as stabilizers, not only adds Convenient, consumption is easily controlled, and product stability can be made to be greatly enhanced；Use polyacrylate, tragacanth, gather Bulk composition made by methacrylate and squalane, and not only heat release is low, little to skin irritation, and can also improve the viscous of product Close intensity；Dimethyl sebacate, to benzene methanesulfonic acid and dioctyl phthalate with the use of, the pliable and tough of product can not only be increased Property, moreover it is possible to improve product stability, make product curing rate moderate, during solidification, do not have albinism.

Detailed description of the invention

Embodiment 1

A kind of adhesive of medical, includes: polyacrylate 3 parts, tragacanth 2 parts, polymethacrylates 1 in parts by weight Part, squalane 2 parts, benzoyl peroxide 3 parts, glycerol three rosin ester 4 parts, dimethyl sebacate 2 parts, hydroquinone 1 part, right Benzene methanesulfonic acid 3 parts, dioctyl phthalate 2 parts, tricalcium phosphate 1 part, sodium alginate 3 parts.

Step 1, pours in stirred tank by polyacrylate, tragacanth, polymethacrylates and squalane, stirred tank true Reciprocal of duty cycle is 0.08MPa, stirs, and stirred tank is heated to 100 DEG C, adds benzoyl peroxide and glycerol three rosin acid Ester, stirs, and is cooled to room temperature and obtains mixture I；

Step 2, by dimethyl sebacate, hydroquinone, to benzene methanesulfonic acid, dioctyl phthalate, tricalcium phosphate and Sargassum Acid sodium is poured in stirred tank, and the vacuum of stirred tank is 0.08MPa, and after stirred tank is heated to 80 DEG C, being cooled to room temperature must mix Compound II；

Step 3, mixes mixture I and mixture II, is heated to 70 DEG C, after insulation 8h, is cooled to room temperature, to obtain final product.

Embodiment 2

A kind of adhesive of medical, includes: polyacrylate 4 parts, tragacanth 3 parts, polymethacrylates 2 in parts by weight Part, squalane 3 parts, benzoyl peroxide 5 parts, glycerol three rosin ester 6 parts, dimethyl sebacate 3 parts, hydroquinone 2 parts, right Benzene methanesulfonic acid 5 parts, dioctyl phthalate 4 parts, tricalcium phosphate 2 parts, sodium alginate 4 parts.

Step 1, pours in stirred tank by polyacrylate, tragacanth, polymethacrylates and squalane, stirred tank true Reciprocal of duty cycle is 0.09MPa, stirs, and stirred tank is heated to 110 DEG C, adds benzoyl peroxide and glycerol three rosin acid Ester, stirs, and is cooled to room temperature and obtains mixture I；

Step 2, by dimethyl sebacate, hydroquinone, to benzene methanesulfonic acid, dioctyl phthalate, tricalcium phosphate and Sargassum Acid sodium is poured in stirred tank, and the vacuum of stirred tank is 0.09MPa, and after stirred tank is heated to 90 DEG C, being cooled to room temperature must mix Compound II；

Step 3, mixes mixture I and mixture II, is heated to 80 DEG C, after insulation 5h, is cooled to room temperature, to obtain final product.

Embodiment 3

A kind of adhesive of medical, includes: polyacrylate 7 parts, tragacanth 5 parts, polymethacrylates 4 in parts by weight Part, squalane 5 parts, benzoyl peroxide 9 parts, glycerol three rosin ester 7 parts, dimethyl sebacate 6 parts, hydroquinone 4 parts, right Benzene methanesulfonic acid 7 parts, dioctyl phthalate 6 parts, tricalcium phosphate 3 parts, sodium alginate 7 parts.

Step 1, pours in stirred tank by polyacrylate, tragacanth, polymethacrylates and squalane, stirred tank true Reciprocal of duty cycle is 0.1MPa, stirs, and stirred tank is heated to 100 DEG C, adds benzoyl peroxide and glycerol three rosin ester, Stir, be cooled to room temperature and obtain mixture I；

Step 2, by dimethyl sebacate, hydroquinone, to benzene methanesulfonic acid, dioctyl phthalate, tricalcium phosphate and Sargassum Acid sodium is poured in stirred tank, and the vacuum of stirred tank is 0.1MPa, and after stirred tank is heated to 80 DEG C, being cooled to room temperature must mix Thing II；

Step 3, mixes mixture I and mixture II, is heated to 90 DEG C, after insulation 2h, is cooled to room temperature, to obtain final product.

Embodiment 4

A kind of adhesive of medical, includes: polyacrylate 8 parts, tragacanth 7 parts, polymethacrylates 6 in parts by weight Part, squalane 7 parts, benzoyl peroxide 10 parts, glycerol three rosin ester 10 parts, dimethyl sebacate 7 parts, hydroquinone 6 parts, To benzene methanesulfonic acid 9 parts, dioctyl phthalate 7 parts, tricalcium phosphate 5 parts, sodium alginate 8 parts.

Step 1, pours in stirred tank by polyacrylate, tragacanth, polymethacrylates and squalane, stirred tank true Reciprocal of duty cycle is 0.08MPa, stirs, and stirred tank is heated to 120 DEG C, adds benzoyl peroxide and glycerol three rosin acid Ester, stirs, and is cooled to room temperature and obtains mixture I；

Step 2, by dimethyl sebacate, hydroquinone, to benzene methanesulfonic acid, dioctyl phthalate, tricalcium phosphate and Sargassum Acid sodium is poured in stirred tank, and the vacuum of stirred tank is 0.1MPa, and after stirred tank is heated to 100 DEG C, being cooled to room temperature must mix Compound II；

Step 3, mixes mixture I and mixture II, is heated to 85 DEG C, after insulation 4h, is cooled to room temperature, to obtain final product.

Embodiment 5

A kind of adhesive of medical, includes: polyacrylate 10 parts, tragacanth 9 parts, polymethacrylates 7 in parts by weight Part, squalane 8 parts, benzoyl peroxide 12 parts, glycerol three rosin ester 12 parts, dimethyl sebacate 9 parts, hydroquinone 7 parts, To benzene methanesulfonic acid 10 parts, dioctyl phthalate 9 parts, tricalcium phosphate 7 parts, sodium alginate 10 parts.

Step 3, mixes mixture I and mixture II, is heated to 75 DEG C, after insulation 6h, is cooled to room temperature, to obtain final product.

Embodiment 1 to 5 gained adhesive of medical and commercially available adhesive of medical are carried out performance test.

(1) curing rate test

In the plate of a diameter of 90mm, add the sodium bicarbonate solution 50mL of 0.3g/L, draw adhesive of medical with dropper, Higher than dripping one at liquid level 5cm, record binding agent hardening time.

(2) adhesive strength

Selecting pig, sheep or rabbit as test leather, thickness is 1～1.5mm, a length of 50mm × 10mm.Use phosphate buffer After the front surface of washleather test piece, dry with cotton swab.Take adhesive of medical 1～2 to drip in test leather front surface so that it is Uniformly spread out, the front surface of another sheet test leather is connected with the grain side of leather scribbling binding agent, firmly compresses about 20s, make The gluing of surfaces of two panels closely bonds equably,.After bonding 10min, bonding test piece one end is fixed, apply at the other end After power 30min, abutting edge does not turns off as qualified.

(3) stability test

After product seals, room temperature is placed, and observes product form, and when there is gel or solidification phenomenon, product is instability.

Result is as follows:

From upper table result, adhesive of medical hardening time of the present invention 8～10s, the pulling force that can bear up to more than 9N, In placing latter 3 years, form is not changed in, and compared with commercially available prod, curing rate is moderate, length stabilization time, adhesive strength are strong.

Claims

1. the preparation method of an adhesive of medical, it is characterised in that: this adhesive of medical includes in parts by weight: polyacrylic acid Ester 4～8 parts, tragacanth 3～7 parts, polymethacrylates 2～6 parts, squalane 3～7 parts, benzoyl peroxide 5～10 Part, glycerol three rosin ester 6～10 parts, dimethyl sebacate 3～7 parts, hydroquinone 2～6 parts, to benzene methanesulfonic acid 5～9 parts, Dioctyl phthalate 4～7 parts, tricalcium phosphate 2～5 parts, sodium alginate 4～8 parts；

The preparation method of described adhesive of medical, comprises the following steps: