CN103599559A - Polylactic acid modified medical operation incision adhesion agent - Google Patents
Polylactic acid modified medical operation incision adhesion agent Download PDFInfo
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- CN103599559A CN103599559A CN201310524107.1A CN201310524107A CN103599559A CN 103599559 A CN103599559 A CN 103599559A CN 201310524107 A CN201310524107 A CN 201310524107A CN 103599559 A CN103599559 A CN 103599559A
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- polylactic acid
- parts
- acid modified
- medical operation
- adhesion agent
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- Materials For Medical Uses (AREA)
Abstract
A preparation method of a polylactic acid modified medical operation incision adhesion agent is characterized in that the adhesion agent comprises the components by weight: 100-120 parts of n-butyl cyanoacrylate, 1-3 parts of hydroquinone, 1-2 parts of sulfur dioxide, 1-3 parts of polylactic acid, 1-3 parts of cis-butenedioic anhydride, and 0.5-1 part of acrylic ester. The materials are mixed uniformly to obtain the product. The adhesion agent has the advantages of easily obtained raw materials, low cost, green environmental protection, convenient use, and good effect.
Description
Technical field
The invention belongs to a kind of medical material.
Background technology
The bonding operative incision of glue have healing fast, infect less, cicatrix is little, pain is light, appearance looks elegant, the feature such as need not take out stitches.
Through Chinese publication retrieval, do not find the scheme identical with present patent application.
Summary of the invention:
The object of the invention is to; A kind of polylactic acid modified medical operation otch adhesive and preparation method thereof is proposed.
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms.
Polylactic acid modified medical operation otch adhesive preparation method of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.
Polylactic acid modified medical operation otch adhesive products of the present invention, can preserve 12 months in lucifuge, lower than 15 ℃.
The present invention compared with prior art its beneficial effect is: performance is more excellent, and storage life reaches 12 months, far above the BCA class medical adhesive storage life of 3 months of prior art.
The specific embodiment:
Below in conjunction with embodiment, the invention will be further described, but embodiments of the present invention are not limited to this.
Polylactic acid modified medical operation otch adhesive of the present invention, raw materials usedly buys acquisition.
Embodiment 1
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 2
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 100 parts of BCAs, 1 part of hydroquinone, 1 part of sulfur dioxide, 1 part of polylactic acid, 1 part of maleic anhydride, 0.5 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 3
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 120 parts of BCAs, 3 parts of hydroquinone, 2 parts of sulfur dioxide, 3 parts of polylactic acid, 3 parts of maleic anhydrides, 1 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 4
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 100 parts of BCAs, 3 parts of hydroquinone, 1 part of sulfur dioxide, 3 parts of polylactic acid, 1 part of maleic anhydride, 1 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 5
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 120 parts of BCAs, 1 part of hydroquinone, 2 parts of sulfur dioxide, 1 part of polylactic acid, 3 parts of maleic anhydrides, 0.5 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Product standard:
Appearance colorless or micro-yellow transparent liquid
Impurity (phosphorus, sulfur, aldehyde, phenol) is qualified
Purity/% >=99 content
Acid number meets the requirements
At in lucifuge, lower than 15 ℃, can preserve 12 months.
Purposes:
1, soft tissue sticks with glue the purposes of agent: be applicable to replace pin to sew up and make skin wound, mouthful hemostasis, coincideing of operative incision, can not stay clear scar.Also can be used for bonding and the hemostasis of interior liver.Substantially curing in 10s under body temperature, after 4 days, can reach maximum intensity.
2, sclerous tissues sticks with glue the purposes of agent: the adhesive of the reparation of bone, artificial hip joint and bone; Dental caries Plugging is used, bonding dentine;
3, for covering and the protection of various surgical incisions and outer wound mouth; For medical pressure-sensing adhesive tape, operative membrane, otch adhesive tape etc.
Claims (2)
1. a polylactic acid modified medical operation otch adhesive, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms.
2. a polylactic acid modified medical operation otch adhesive preparation method, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310524107.1A CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310524107.1A CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103599559A true CN103599559A (en) | 2014-02-26 |
Family
ID=50117861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310524107.1A Pending CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599559A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251038A (en) * | 2015-10-09 | 2016-01-20 | 中国科学院长春应用化学研究所 | Anti-infection soft tissue medical adhesive and preparation method thereof |
| CN112156221A (en) * | 2020-10-30 | 2021-01-01 | 北京福爱乐科技发展有限公司 | Pyrogen-free biocompatible medical adhesive material and preparation method thereof |
| CN112190753A (en) * | 2020-10-30 | 2021-01-08 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707A (en) * | 2020-10-30 | 2021-01-26 | 北京福爱乐科技发展有限公司 | Anti-infection medical adhesive material and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3527841A (en) * | 1968-04-10 | 1970-09-08 | Eastman Kodak Co | Alpha-cyanoacrylate adhesive compositions |
| US5328687A (en) * | 1993-03-31 | 1994-07-12 | Tri-Point Medical L.P. | Biocompatible monomer and polymer compositions |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
-
2013
- 2013-10-30 CN CN201310524107.1A patent/CN103599559A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3527841A (en) * | 1968-04-10 | 1970-09-08 | Eastman Kodak Co | Alpha-cyanoacrylate adhesive compositions |
| US5328687A (en) * | 1993-03-31 | 1994-07-12 | Tri-Point Medical L.P. | Biocompatible monomer and polymer compositions |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251038A (en) * | 2015-10-09 | 2016-01-20 | 中国科学院长春应用化学研究所 | Anti-infection soft tissue medical adhesive and preparation method thereof |
| CN112156221A (en) * | 2020-10-30 | 2021-01-01 | 北京福爱乐科技发展有限公司 | Pyrogen-free biocompatible medical adhesive material and preparation method thereof |
| CN112190753A (en) * | 2020-10-30 | 2021-01-08 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707A (en) * | 2020-10-30 | 2021-01-26 | 北京福爱乐科技发展有限公司 | Anti-infection medical adhesive material and preparation method thereof |
| CN112190753B (en) * | 2020-10-30 | 2022-03-18 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707B (en) * | 2020-10-30 | 2022-05-27 | 卫纳塞德(北京)医疗科技有限公司 | Anti-infection medical adhesive material and preparation method thereof |
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| C12 | Rejection of a patent application after its publication | ||
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Application publication date: 20140226 |