CN105194723B - A kind of antibacterial orthopaedics adhesive and preparation method thereof - Google Patents
A kind of antibacterial orthopaedics adhesive and preparation method thereof Download PDFInfo
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- CN105194723B CN105194723B CN201510621989.2A CN201510621989A CN105194723B CN 105194723 B CN105194723 B CN 105194723B CN 201510621989 A CN201510621989 A CN 201510621989A CN 105194723 B CN105194723 B CN 105194723B
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- antibacterial
- orthopaedics
- pentaerythrite
- isomalt
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Abstract
The invention discloses a kind of antibacterial orthopaedics adhesive and preparation method thereof, the adhesive is made up of each component of following mass parts：45 67 parts of the secondary monooctyl ester of α alpha-cyanoacrylates, 2 5.5 parts of benzoyl peroxide, 13 27 parts of pentaerythrite, 7 13 parts of sodium alginate, 2 10 parts of hydroxyethyl cellulose, 3 11 parts of isomalt, 7 29 parts of Fibrin Glue, 4 21 parts of hydroxy propyl methacrylate, 0.5 2 parts of vinyl triamine, 5 18 parts of D D-sorbites.Adhesives intensity produced by the present invention is high, good anti-bacterial effect, has no adverse reaction, is with a wide range of applications.
Description
Technical field
The invention belongs to field of medical materials, and in particular to a kind of antibacterial orthopaedics adhesive and preparation method thereof.
Background technology
The usage history of adhesive of medical is long, but until recent decades have just obtained rapid development.Adhesive of medical
By its purposes, its adhesive effect is related to the following aspects in human-body biological cell:(1) bonding between cell；(2) human body
Internal active mass and the bonding of inactive part；(3) bonding between tissue and exterior materials.It is specifically categorized as：
Soft tissue is with adhesive, dental adhesive, orthopaedics adhesive and skin pressure sensitive adhesive.
Orthopaedics adhesive is generally used for the combination and positioning of bone, joint in operation, special due to its use environment, right
Its adhesive property and anti-microbial property propose higher requirement.
The content of the invention
In order to overcome above the deficiencies in the prior art, the invention provides a kind of antibacterial orthopaedics adhesive and its preparation side
Method, obtained adhesives intensity is high, good anti-bacterial effect, has no adverse reaction, is with a wide range of applications.
The technical solution adopted by the present invention is：A kind of antibacterial orthopaedics adhesive, is made up of following content of component：Alpha-cyano
The secondary monooctyl ester 45-67 parts of acrylic acid, benzoyl peroxide 2-5.5 parts, pentaerythrite 13-27 parts, sodium alginate 7-13 parts, ethoxy
Cellulose 2-10 parts, isomalt 3-11 parts, Fibrin Glue 7-29 parts, hydroxy propyl methacrylate 4-21 parts, ethene
Base triamine 0.5-2 parts, D- D-sorbite 5-18 parts.
Preferably, a kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：The secondary monooctyl ester of alpha-cyanoacrylate
49-60 parts, benzoyl peroxide 2.5-5 parts, pentaerythrite 16-24 parts, sodium alginate 8-11 parts, hydroxyethyl cellulose 4-9 parts,
Isomalt 5-10 parts, Fibrin Glue 11-22 parts, hydroxy propyl methacrylate 6-16 parts, vinyl triamine 1-1.8
Part, D- D-sorbite 7-12 parts.
It is furthermore preferred that a kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：Alpha-cyanoacrylate Zhong Xin
53 parts of ester, 4 parts of benzoyl peroxide, 21 parts of pentaerythrite, 9 parts of sodium alginate, 6 parts of hydroxyethyl cellulose, isomalt 8
Part, 16 parts of Fibrin Glue, 12 parts of hydroxy propyl methacrylate, 1.5 parts of vinyl triamine, 9 parts of D- D-sorbites.
A kind of preparation method of antibacterial orthopaedics adhesive, comprises the following steps：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 40-60min is stirred at 160-190 DEG C, obtains compound one；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 90-130 DEG C in nitrogen protection, stirs
Mix to uniform, obtain compound two；
(3) compound two obtained by step (2) is placed in 120-160 DEG C of baking oven and dried, cooled down, institute is produced after ultraviolet-sterilization
State antibacterial orthopaedics adhesive.
Stir speed (S.S.) is 900-1200r/min in above-mentioned steps (1).
Stir speed (S.S.) is 700-950r/min in above-mentioned steps (2).
Beneficial effect：Antibacterial orthopaedics adhesives intensity produced by the present invention is between 76.8-81.4N, Escherichia coli
Sterilizing rate is between 96.4-98.3%, and staphylococcus aureus sterilizing rate is between 94.6-97.3%, by between component
Synergy, reach the high effect with antibacterial of adhesion strength, while do not produce adverse reaction, be with a wide range of applications.
Embodiment
Embodiment 1
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：45 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
2 parts of BP, 13 parts of pentaerythrite, 7 parts of sodium alginate, 2 parts of hydroxyethyl cellulose, 3 parts of isomalt, fiber egg
7 parts of white glue, 4 parts of hydroxy propyl methacrylate, 0.5 part of vinyl triamine, 5 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 40min is stirred at 160 DEG C, obtains compound one, wherein stir speed (S.S.) is 900r/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 90 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 700r/min；
(3) compound two obtained by step (2) is placed in 120 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Embodiment 2
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：67 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
5.5 parts of BP, 27 parts of pentaerythrite, 13 parts of sodium alginate, 10 parts of hydroxyethyl cellulose, 11 parts of isomalt,
29 parts of Fibrin Glue, 21 parts of hydroxy propyl methacrylate, 2 parts of vinyl triamine, 18 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 60min is stirred at 190 DEG C, obtains compound one, wherein stir speed (S.S.) is 1200r/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 130 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 950r/min；
(3) compound two obtained by step (2) is placed in 160 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Embodiment 3
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：49 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
2.5 parts of BP, 16 parts of pentaerythrite, 8 parts of sodium alginate, hydroxyethyl cellulose 4- parts, 5 parts of isomalt, fibre
11 parts of fibrillarin glue, 6 parts of hydroxy propyl methacrylate, 1 part of vinyl triamine, 7 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 45min is stirred at 170 DEG C, obtains compound one, wherein stir speed (S.S.) is 950r/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 100 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 750r/min；
(3) compound two obtained by step (2) is placed in 125 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Embodiment 4
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：60 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
5 parts of BP, 24 parts of pentaerythrite, 11 parts of sodium alginate, 9 parts of hydroxyethyl cellulose, 10 parts of isomalt, fiber
22 parts of protein adhesive, 16 parts of hydroxy propyl methacrylate, 1.8 parts of vinyl triamine, 12 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 55min is stirred at 180 DEG C, obtains compound one, wherein stir speed (S.S.) is 1100r/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 120 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 900r/min；
(3) compound two obtained by step (2) is placed in 150 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Embodiment 5
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：53 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
4 parts of BP, 21 parts of pentaerythrite, 9 parts of sodium alginate, 6 parts of hydroxyethyl cellulose, 8 parts of isomalt, fiber egg
16 parts of white glue, 12 parts of hydroxy propyl methacrylate, 1.5 parts of vinyl triamine, 9 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing
In machine, 50min is stirred at 175 DEG C, obtains compound one, wherein stir speed (S.S.) is 1050/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 110 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 850r/min；
(3) compound two obtained by step (2) is placed in 140 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Comparative example 1
Difference with embodiment 5 is to be not added with D- D-sorbites.
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：53 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
4 parts of BP, 21 parts of pentaerythrite, 9 parts of sodium alginate, 6 parts of hydroxyethyl cellulose, 8 parts of isomalt, fiber egg
16 parts of white glue, 12 parts of hydroxy propyl methacrylate, 1.5 parts of vinyl triamine.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate and alkenyl triamine are placed in mixing and blending machine, at 175 DEG C
Lower stirring 50min, compound one is obtained, wherein stir speed (S.S.) is 1050/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 110 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 850r/min；
(3) compound two obtained by step (2) is placed in 140 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Comparative example 2
Difference with embodiment 5 is to be not added with isomalt.
A kind of antibacterial orthopaedics adhesive, is made up of each component of following mass parts：53 parts of the secondary monooctyl ester of alpha-cyanoacrylate, mistake
4 parts of BP, 21 parts of pentaerythrite, 9 parts of sodium alginate, 6 parts of hydroxyethyl cellulose, 16 parts of Fibrin Glue, methyl-prop
12 parts of olefin(e) acid hydroxypropyl acrylate, 1.5 parts of vinyl triamine, 9 parts of D- D-sorbites.
Preparation method：
(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide, pentaerythrite, sodium alginate,
Hydroxyethyl cellulose, hydroxy propyl methacrylate, vinyl triamine and D- D-sorbites are placed in mixing and blending machine, at 175 DEG C
Lower stirring 50min, compound one is obtained, wherein stir speed (S.S.) is 1050/min；
(2) Fibrin Glue is added into compound one obtained by step (1), is heated to 110 DEG C in nitrogen protection, stirring is extremely
Uniformly, compound two is obtained, wherein stir speed (S.S.) is 850r/min；
(3) compound two obtained by step (2) is placed in 140 DEG C of baking ovens and dried, cooled down, produced after ultraviolet-sterilization described anti-
Bacterium orthopaedics adhesive.
Performance test：
Binder performance test is as shown in the table made from embodiment 1-5 and comparative example 1-2：
As can be seen from the above table：Antibacterial orthopaedics adhesives intensity made from embodiment 1-5 76.8-81.4N it
Between, for Escherichia coli sterilizing rate between 96.4-98.3%, staphylococcus aureus sterilizing rate is and right between 94.6-97.3%
D- D-sorbites are not added with ratio 1, obtained antibacterial orthopaedics adhesives intensity is 68.0N, and Escherichia coli sterilizing rate is
89.3%, staphylococcus aureus sterilizing rate is 79.6%；Isomalt, obtained antibacterial bone are not added with comparative example 2
Section's adhesives intensity is 61.2N, and Escherichia coli sterilizing rate is 95.2%, and staphylococcus aureus sterilizing rate is 95.2%.
It follows that it is high and anti-to reach adhesion strength by the synergy between component for antibacterial orthopaedics adhesive produced by the present invention
The effect of bacterium, while do not produce adverse reaction, it is with a wide range of applications.
Claims (5)
1. a kind of antibacterial orthopaedics adhesive, it is characterised in that be made up of the component of following mass parts：The secondary monooctyl ester of alpha-cyanoacrylate
45-67 parts, benzoyl peroxide 2-5.5 parts, pentaerythrite 13-27 parts, sodium alginate 7-13 parts, hydroxyethyl cellulose 2-10
Part, isomalt 3-11 parts, Fibrin Glue 7-29 parts, hydroxy propyl methacrylate 4-21 parts, vinyl triamine 0.5-2
Part, D- D-sorbite 5-18 parts；Preparation method：(1) above-mentioned mass parts are pressed, by the secondary monooctyl ester of alpha-cyanoacrylate, benzoyl peroxide first
Acyl, pentaerythrite, sodium alginate, hydroxyethyl cellulose, isomalt, hydroxy propyl methacrylate, vinyl triamine and
D- D-sorbites are placed in mixing and blending machine, and 40-60min is stirred at 160-190 DEG C, obtain compound one；(2) to step
(1) Fibrin Glue is added in gained compound one, is heated to 90-130 DEG C in nitrogen protection, is stirred until homogeneous, is mixed
Material two；(3) compound two obtained by step (2) is placed in 120-160 DEG C of baking oven and dried, cooled down, produced after ultraviolet-sterilization described
Antibacterial orthopaedics adhesive.
2. a kind of antibacterial orthopaedics adhesive according to claim 1, it is characterised in that by the component group of following mass parts
Into：The secondary monooctyl ester 49-60 parts of alpha-cyanoacrylate, benzoyl peroxide 2.5-5 parts, pentaerythrite 16-24 parts, sodium alginate 8-11
Part, hydroxyethyl cellulose 4-9 parts, isomalt 5-10 parts, Fibrin Glue 11-22 parts, hydroxy propyl methacrylate 6-
16 parts, vinyl triamine 1-1.8 parts, D- D-sorbite 7-12 parts.
3. a kind of antibacterial orthopaedics adhesive according to claim 1, it is characterised in that by the component group of following mass parts
Into：53 parts of the secondary monooctyl ester of alpha-cyanoacrylate, 4 parts of benzoyl peroxide, 21 parts of pentaerythrite, 9 parts of sodium alginate, hydroxy ethyl fiber
6 parts of element, 8 parts of isomalt, 16 parts of Fibrin Glue, 12 parts of hydroxy propyl methacrylate, 1.5 parts of vinyl triamine, D-
9 parts of D-sorbite.
A kind of 4. antibacterial orthopaedics adhesive according to claim 1, it is characterised in that stir speed (S.S.) in the step (1)
For 900-1200r/min.
A kind of 5. antibacterial orthopaedics adhesive according to claim 1, it is characterised in that stir speed (S.S.) in the step (2)
For 700-950r/min.
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| CN201510621989.2A CN105194723B (en) | 2015-09-25 | 2015-09-25 | A kind of antibacterial orthopaedics adhesive and preparation method thereof |
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| CN201510621989.2A CN105194723B (en) | 2015-09-25 | 2015-09-25 | A kind of antibacterial orthopaedics adhesive and preparation method thereof |
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| CN105194723B true CN105194723B (en) | 2018-02-13 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105770980A (en) * | 2016-04-07 | 2016-07-20 | 苏州蔻美新材料有限公司 | Medical adhesive and preparation method thereof |
| CN106362196A (en) * | 2016-08-30 | 2017-02-01 | 胡何辉 | Orthopaedic binding agent with excellent biocompatibility and preparation method thereof |
| CN106362199A (en) * | 2016-11-01 | 2017-02-01 | 金福兴 | Medical adhesive with good antibacterial property and preparation method of medical adhesive |
| CN109847093B (en) * | 2019-02-23 | 2021-10-01 | 兰州大学第一医院 | Antibacterial orthopedic adhesive and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
| CN104922726A (en) * | 2015-06-08 | 2015-09-23 | 苏州乔纳森新材料科技有限公司 | Degradable adhesive for soft tissues and preparation method for degradable adhesive |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2014237970B2 (en) * | 2013-03-15 | 2017-01-05 | Cook Medical Technologies Llc | Adhesive medical products and methods for treating gastrointestinal lesions |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
| CN104922726A (en) * | 2015-06-08 | 2015-09-23 | 苏州乔纳森新材料科技有限公司 | Degradable adhesive for soft tissues and preparation method for degradable adhesive |
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Inventor after: Li Ziyin Inventor after: Lin Xiaojie Inventor after: Jia Zhongyu Inventor before: Yu Guozhen Inventor before: Jin Zhongen Inventor before: OUYANG ZHIKUN |
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Effective date of registration: 20180115 Address after: High tech Zone 710000 Shaanxi city of Xi'an Province Tang Yan Road Plaza Garden No. 2-10535 Applicant after: Xi'an dimensional Biological Technology Co., Ltd. Address before: 215163 Suzhou province high tech Zone Longshan Road, No. 10, Jiangsu Applicant before: Suzhou Koumei New Material Co., Ltd. |
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